3,150 results match your criteria Clinical Ophthalmology[Journal]


Treatment of large avascular retinal pigment epithelium detachments in age-related macular degeneration with aflibercept, photodynamic therapy, and triamcinolone acetonide.

Clin Ophthalmol 2019 1;13:233-241. Epub 2019 Feb 1.

Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, 7491 Trondheim, Norway,

Purpose: To evaluate the use of aflibercept, triamcinolone acetonide, and photodynamic therapy (PDT) in the treatment of avascular pigment epithelium detachments (aPEDs).

Patients And Methods: Patients with treatment-naïve aPEDs ≥1,500 µm in diameter were randomized to treatment or observation. Treatment consisted of 6 monthly intravitreal injections of aflibercept. Read More

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http://dx.doi.org/10.2147/OPTH.S188315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362940PMC
February 2019

Dry eye disease ranking among common reasons for seeking eye care in a large US claims database.

Clin Ophthalmol 2019 1;13:225-232. Epub 2019 Feb 1.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Objectives: Dry eye disease (DED) is a complex multifactorial condition of the ocular surface characterized by symptoms of ocular discomfort, irritation, and visual disturbance. Data previously reported from this study showed an increase in prevalence and incidence of DED with age and over time. The objective of this study was to compare the ranking of DED prevalence among other ocular conditions that led patients to seek eye care. Read More

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http://dx.doi.org/10.2147/OPTH.S188314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362914PMC
February 2019

Patient-reported severity of dry eye and quality of life in diabetes.

Clin Ophthalmol 2019 25;13:217-224. Epub 2019 Jan 25.

School of Health and Life Sciences, Glasgow Caledonian University (GCU), Glasgow G4 0BA, UK,

Purpose: The purpose of the study was to assess the relationship between patient-reported severity of dry eye disease (DED), quality of life (QoL), presence of diabetic retinopathy (DR) and length of disease duration in people with type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2).

Patients And Methods: A survey of 152 people (110 with and 42 without diabetes). All participants completed the Ocular Surface Disease Index (OSDI) and Dry Eye-related Quality of Life Score (DEQS) questionnaires. Read More

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http://dx.doi.org/10.2147/OPTH.S184173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354694PMC
January 2019

Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019
1 Read

Surgical experience with a redesigned, fully preloaded, hydrophobic acrylic intraocular lens in challenging cases of pseudoexfoliation syndrome, phacodonesis, and small pupils.

Clin Ophthalmol 2019 22;13:199-206. Epub 2019 Jan 22.

Borkenstein & Borkenstein, Privatklinik der Kreuzschwestern Graz, Graz, Austria,

Purpose: The purpose of this study was to describe our surgical experience and evaluate safety and postoperative outcomes of a fully preloaded, monofocal, hydrophobic acrylic intraocular lens (IOL) (CT LUCIA 611P) with a newly designed optic-haptic junction in severe cases of pseudoexfoliation (PXF) syndrome, phacodonesis, and small pupils.

Setting: This study was conducted in Borkenstein & Borkenstein, private practice, Privatklinik der Kreuzschwestern Graz, Austria.

Patients And Methods: This study presents outcomes of 15 eyes of 15 patients implanted with CT LUCIA 611P IOL with improved optical properties and more rigid and wider optic- haptic junction. Read More

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https://www.dovepress.com/surgical-experience-with-a-redesig
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http://dx.doi.org/10.2147/OPTH.S194420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348969PMC
January 2019
6 Reads

TearCare system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare treatment on subjects with dry eye disease.

Authors:
David Badawi

Clin Ophthalmol 2019 22;13:189-198. Epub 2019 Jan 22.

Clinical Trials Section, Central Eye Care, Arlington Heights, IL, USA,

Purpose: Evaluation of the safety and effectiveness of a TearCare retreatment in adult subjects with clinically significant dry eye disease (DED).

Patients And Methods: This was an extension of an initial 6-month, prospective, single-center, randomized, parallel-group pilot study. In the initial study, subjects with DED were randomized to either a single TearCare treatment or 4 weeks of daily warm compress therapy. Read More

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http://dx.doi.org/10.2147/OPTH.S191588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348966PMC
January 2019

Incidence and prevalence of vitreomacular traction with and without macular hole in Germany.

Clin Ophthalmol 2019 15;13:177-188. Epub 2019 Jan 15.

Department of Ophthalmology, Faculty of Life Course Sciences and Medicine, King's College London, London, UK.

Purpose: Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany.

Materials And Methods: A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies. Read More

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http://dx.doi.org/10.2147/OPTH.S188704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339449PMC
January 2019

Comparing the long-term impact on health care resources utilization and costs due to various single-piece acrylic monofocal intraocular lens implantation during cataract surgery: a cost-consequence analysis for the United Kingdom, Italy, and Denmark.

Clin Ophthalmol 2019 14;13:169-176. Epub 2019 Jan 14.

Patient Access Services, Novartis Healthcare Private Limited, Hyderabad, India.

Purpose: The objective of this study was to estimate the cost impact of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy and its complications due to single-piece acrylic monofocal intraocular lenses (IOLs) in the healthcare setting of United Kingdom, Italy, and Denmark.

Materials And Methods: A hypothetical cost-consequence model was developed to estimate economic burden of Nd:YAG laser capsulotomy due to different single-piece acrylic monofocal IOLs. Cumulative incidence of Nd:YAG laser capsulotomy at 3 years after cataract surgery with five single-piece monofocal acrylic IOLs was sourced from retrospective data analysis of electronic medical records of cataract patients in the United Kingdom. Read More

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http://dx.doi.org/10.2147/OPTH.S190754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338125PMC
January 2019

360° ab-interno trabeculotomy in refractory primary open-angle glaucoma.

Clin Ophthalmol 2019 11;13:161-168. Epub 2019 Jan 11.

University of Oklahoma, Oklahoma City, OK, USA.

Purpose: The purpose of this study was to evaluate the safety and efficacy of microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using the TRAB360 device as a stand-alone procedure in patients with refractory primary open-angle glaucoma (POAG) and preoperative IOP ≥18 mmHg.

Setting: This study evaluated patients treated in a tertiary-referral clinical practice setting.

Design: This study is a retrospective analysis of 81 eyes. Read More

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https://www.dovepress.com/360deg-ab-interno-trabeculotomy-in
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http://dx.doi.org/10.2147/OPTH.S189260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333157PMC
January 2019
4 Reads

Local anesthesia and anxiolytic techniques for oculoplastic surgery.

Clin Ophthalmol 2019 10;13:153-160. Epub 2019 Jan 10.

Department of Anesthesia, Michael Garron Hospital, University of Toronto, Toronto, ON Canada.

This study discusses local anesthetic agents, administration techniques, ancillary considerations, and safety precautions for oculoplastic surgery including eyelid, lacrimal, orbital, and temporal artery biopsy procedures. Methods for reducing patient apprehension and discomfort including systemic premedication, topical pre-anesthetic, visual, auditory and tactile distraction techniques, regional blocks, small gauge needles, warmed lidocaine, and buffered lidocaine are discussed. Read More

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https://www.dovepress.com/local-anesthesia-and-anxiolytic-te
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http://dx.doi.org/10.2147/OPTH.S188790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330983PMC
January 2019
11 Reads

Corneal incision architecture: VICTUS femtosecond laser vs manual keratome.

Clin Ophthalmol 2019 10;13:147-152. Epub 2019 Jan 10.

Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil,

Purpose: To evaluate anatomical differences between laser (VICTUS) and manual constructed phacoemulsification incisions.

Setting: Study was conducted at the Hospital de Olhos Paulista, Sao Paulo, Brazil.

Design: This is a prospective, observational, consecutive nonrandomized cohort. Read More

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https://www.dovepress.com/corneal-incision-architecture-vict
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http://dx.doi.org/10.2147/OPTH.S181144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330980PMC
January 2019
2 Reads

Lamellar macular hole surgery - current concepts, future prospects.

Clin Ophthalmol 2019 8;13:143-146. Epub 2019 Jan 8.

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Lamellar macular holes present distinct morphological features including tractional or non-tractional epimacular membranes, foveal tissue alterations, defects of the outer retinal layers, or a separation of the retinal layers. At present, degenerative lamellar holes are differentiated from tractional holes based on the morphological characteristics seen in OCT. The current treatment approach is based on this gross differentiation. Read More

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http://dx.doi.org/10.2147/OPTH.S188309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329342PMC
January 2019
2 Reads

Long-term safety of posterior chamber implantable phakic contact lens for the correction of myopia.

Clin Ophthalmol 2019 7;13:137-142. Epub 2019 Jan 7.

The Eye Foundation, Coimbatore, India,

Purpose: To review the safety of the implantable phakic contact lens (IPCL V1, Caregroup Sight Solutions, India) for correction of myopia and myopic astigmatism.

Methods: Retrospective interventional case series including 134 eyes which underwent IPCL implantation for correction of myopia and myopic astigmatism at a tertiary eye care hospital in South India. Intraoperative and postoperative complications were analyzed. Read More

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https://www.dovepress.com/long-term-safety-of-posterior-cham
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http://dx.doi.org/10.2147/OPTH.S185304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327895PMC
January 2019
4 Reads

Assessment of tear-evaporation rate in thyroid-gland patients.

Clin Ophthalmol 2019 7;13:131-135. Epub 2019 Jan 7.

Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia,

Objective: To assess the tear-evaporation rate in thyroid-gland patients using a VapoMeter.

Methods: Twenty thyroid gland patients aged 18-43 years (mean 34.3±6. Read More

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https://www.dovepress.com/assessment-of-tear-evaporation-rat
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http://dx.doi.org/10.2147/OPTH.S188614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327900PMC
January 2019
6 Reads

Prospective evaluation of a novel silicone corneal shield after PRK: 6-month efficacy, safety, and predictability outcomes.

Clin Ophthalmol 2019 7;13:115-121. Epub 2019 Jan 7.

Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA,

Purpose: The aim of this study was to report the 1-week and 6-month refractive outcomes of eyes treated with a novel silicone corneal shield designed to improve visual recovery after photorefractive keratectomy (PRK).

Patients And Methods: This prospective, observational clinical trial recruited 45 myopic eyes with or without astigmatism at a university eye clinic to undergo wavefront-guided PRK followed by application of an investigational silicone corneal shield that was removed on postoperative day 4. The primary outcome measures were efficacy, predictability, and safety at the 6-month visit. Read More

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https://www.dovepress.com/prospective-evaluation-of-a-novel-
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http://dx.doi.org/10.2147/OPTH.S183120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327892PMC
January 2019
6 Reads

Enhancement-procedure outcomes in patients implanted with the Precisight multicomponent intraocular lens.

Clin Ophthalmol 2019 7;13:107-114. Epub 2019 Jan 7.

Research Department, Athens Eye Hospital, Athens, Greece.

Purpose: Eyes that have undergone phacoemulsification with implantation of a multicomponent intraocular lens (MCIOL) may further undergo an enhancement procedure for correction of residual refractive errors. The enhancement procedure is accomplished by exchanging the front lens used in the primary surgery with another lens containing the correct dioptric power. We evaluated the efficacy and safety of enhancement procedures among eyes that received an MCIOL. Read More

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http://dx.doi.org/10.2147/OPTH.S188383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327896PMC
January 2019
2 Reads

Comparison of two devices to simulate vision with intraocular lenses.

Clin Ophthalmol 2019 4;13:123-130. Epub 2019 Jan 4.

Institute for Ophthalmic Research, Eberhard Karls University Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany,

Introduction: The simulation of vision with intraocular lenses (IOLs) prior to the clinical validation is of great interest for manufacturers as well as clinicians. We have tested the influence of different IOLs on the perception of contrast using different devices.

Materials And Methods: A Rassow telescope and the VirtIOL have been used to assess the contrast sensitivity function (CSF) through monfocal IOL (CT Asphina 409 MP, IOL 1), multifocal IOL (AT LISA tri 839 MP, IOL 2) and extended-depth-of-focus-IOL (TECNIS Symfony ZXR00, IOL3) in 21 participants, aged between 22 and 29 years. Read More

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http://dx.doi.org/10.2147/OPTH.S188890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324601PMC
January 2019
2 Reads

Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography.

Clin Ophthalmol 2019 31;13:95-105. Epub 2018 Dec 31.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA,

Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).

Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. Read More

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http://dx.doi.org/10.2147/OPTH.S185468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318713PMC
December 2018
2 Reads

Periocular injection of candesartan-PLGA microparticles inhibits laser-induced experimental choroidal neovascularization.

Clin Ophthalmol 2019 31;13:87-93. Epub 2018 Dec 31.

Department of Ophthalmology, Osaka Medical College, Osaka, Japan,

Purpose: Microparticle technology enables local administration of medication. The purpose of this study was to examine the inhibitory effect of locally administered candesartan (CAN)-encapsulated microparticles on experimental choroidal neovascularization (CNV).

Methods: Laser photocoagulation was used to induce CNV in Brown Norway rats. Read More

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http://dx.doi.org/10.2147/OPTH.S181110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318708PMC
December 2018
4 Reads

Safety and efficacy of twice daily administration of KPI-121 1% for ocular inflammation and pain following cataract surgery.

Clin Ophthalmol 2019 27;13:69-86. Epub 2018 Dec 27.

Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.

Purpose: KPI-121 is a nanoparticle suspension of loteprednol etabonate with improved ocular pharmacokinetics compared with marketed formulations. The efficacy and safety of KPI-121 1% ophthalmic suspension (INVELTYS™) dosed twice daily (BID) were evaluated in participants who had undergone cataract surgery.

Materials And Methods: In two multicenter, randomized, double-masked, parallel-group, vehicle-controlled clinical trials, 386 participants with ≥ grade 2 anterior chamber cells (≥6 cells) on the day following routine cataract surgery were treated with KPI-121 1% and 325 participants were treated with placebo (vehicle); each group was dosed BID for 2 weeks. Read More

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https://www.dovepress.com/safety-and-efficacy-of-twice-daily
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http://dx.doi.org/10.2147/OPTH.S185800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311334PMC
December 2018
9 Reads

A paradigm shift in eye banking: how new models are challenging the status quo.

Clin Ophthalmol 2019 27;13:63-67. Epub 2018 Dec 27.

HDR Research Center, Hoopes Vision, Draper, UT, USA,

This article presents a fact-based, direct approach in order to evaluate the strengths and short comings of both local eye banks and larger companies that have penetrated the market of eye donation. By taking a non-biased approach to the topic, the goal of this article is to create a platform, which furthers the discussion. We focus on SightLife and CorneaGen as well as local eye banks and how their models differ in terms of tissue procurement, distribution, and surgeon partnership. Read More

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http://dx.doi.org/10.2147/OPTH.S181534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311318PMC
December 2018
1 Read

Prospective randomized comparative study between venturi and peristaltic pumps in WhiteStar Signature phacoemulsification machine.

Clin Ophthalmol 2019 27;13:49-52. Epub 2018 Dec 27.

Cataract Sector, Universidade Federal de São Paulo, São Paulo, Brazil.

Purpose: To compare intraoperative parameters between venturi and peristaltic pump in WhiteStar Signature phacoemulsification machine using the bevel-down technique.

Setting: Hospital Oftalmológico de Brasília, Brasília, Federal District, Brazil.

Design: Prospective, comparative, patient-masked study. Read More

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http://dx.doi.org/10.2147/OPTH.S177978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311335PMC
December 2018
1 Read

Development of a new algorithm based on FDT Matrix perimetry and SD-OCT to improve early glaucoma detection in primary care.

Clin Ophthalmol 2019 27;13:33-42. Epub 2018 Dec 27.

IOBA-Eye Institute, Universidad de Valladolid, Valladolid, Spain,

Purpose: The purpose of this study was to develop an objective algorithm to discriminate the earliest stages of glaucoma using frequency doubling technology (FDT) Matrix perimetry and spectral domain-optical coherence tomography (OCT) technology to improve primary care detection.

Materials And Methods: Three hundred six eyes (mean age 58.67±15. Read More

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http://dx.doi.org/10.2147/OPTH.S177581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311325PMC
December 2018
1 Read

Risk factors for ocular surface damage in Mexican patients with dry eye disease: a population-based study.

Clin Ophthalmol 2019 21;13:53-62. Epub 2018 Dec 21.

Cornea and Refractive Surgery Service, Instituto de Oftalmologia Conde de Valenciana, I.A.P. Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico.

Purpose: To analyze potential risk factors for ocular surface damage in a representative population of Mexican patients with dry eye disease (DED).

Patients And Methods: A prospective and cross-sectional population-based epidemiologic cohort study was conducted through a survey of patients with symptoms, signs, known preexisting diagnosis, and clinical conditions related to DED. Fluorescein staining, tear break-up time (TBUT), and Oxford lissamine green staining were performed on both eyes of patients enrolled in the study. Read More

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http://dx.doi.org/10.2147/OPTH.S190803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306075PMC
December 2018
2 Reads

Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty.

Clin Ophthalmol 2019 21;13:43-48. Epub 2018 Dec 21.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan,

Purpose: The aim of this study was to describe the postoperative outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed using our newly developed graft inserter (NS Endo-Inserter) and compare the findings with those for DSAEK performed using the Busin glide.

Patients And Methods: In this retrospective, case-control, institutional study, we studied the clinical outcomes of DSAEK performed using the NS Endo-Inserter (NS group, n=13) or the Busin glide (Busin group, n=10) for patients with corneal endothelial dysfunction. Clinical parameters, including the distance-corrected visual acuity (DCVA), endothelial cell (EC) loss, and intraoperative/postoperative complications, were assessed over a 6-month follow-up period. Read More

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http://dx.doi.org/10.2147/OPTH.S182628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306049PMC
December 2018
1 Read

Timing of neovascular regression in eyes with high-risk proliferative diabetic retinopathy without macular edema treated initially with intravitreous bevacizumab.

Clin Ophthalmol 2019 19;13:27-31. Epub 2018 Dec 19.

Vitreoretinal Department, Ibn Al-Haetham Teaching Eye Hospital, Baghdad, Iraq,

Purpose: To determine the timing of neovascular regression after intravitreous injection of bevacizumab (Avastin) 1.25 mg given as initial therapy for eyes with high-risk proliferative diabetic retinopathy (PDR) without clinically significant macular edema (CSME).

Patients And Methods: In this prospective uncontrolled interventional study, eyes with high-risk PDR without CSME were treated initially with intravitreous injections of bevacizumab 1. Read More

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http://dx.doi.org/10.2147/OPTH.S182420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304070PMC
December 2018
1 Read

Glue and glide: a novel technique for pterygium conjunctival autograft.

Clin Ophthalmol 2019 18;13:25-26. Epub 2018 Dec 18.

Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK,

Conjunctival autograft adhesion with fibrin glue has gained rapid popularity in pterygium excision surgery and is now the technique of choice in many centers worldwide. It has enabled a suture-free technique, reducing surgical time and postoperative pain. However, the adhesive's components form a fibrin clot 10 seconds after mixing, and in this time, the surgeon must complete glue application, grabbing of the instruments and adequate placement of the conjunctival patch. Read More

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http://dx.doi.org/10.2147/OPTH.S191833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302804PMC
December 2018
1 Read

Anatomical and functional response after conversion to aflibercept using the treat-and-extend regimen protocol in bevacizumab treatment-resistant wet age-related macular degeneration.

Clin Ophthalmol 2019 18;13:17-23. Epub 2018 Dec 18.

Helsinki Retina Research Group, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland,

Objective: To evaluate the functional and anatomical response after the switch from bevacizumab to aflibercept in treatment-resistant wet age-related macular degeneration (wAMD) using the treat-and-extend regimen protocol.

Design: A retrospective single-center study.

Participants: The registry consisted of 576 patients with wAMD. Read More

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http://dx.doi.org/10.2147/OPTH.S188624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302797PMC
December 2018
1 Read

Investigation of intraocular pressure fluctuation as a risk factor of glaucoma progression.

Clin Ophthalmol 2019 18;13:9-16. Epub 2018 Dec 18.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany,

Purpose: Since the role of short- and long-term intraocular pressure (IOP) fluctuation as a predictor of glaucoma progression is still controversial, the purpose of this study was to investigate the role of IOP fluctuation in a non-selected patient cohort.

Materials And Methods: Two-hundred and forty eyes of 120 glaucoma patients (51% female) with a mean age of 64.5 years were included. Read More

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http://dx.doi.org/10.2147/OPTH.S186526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302802PMC
December 2018
1 Read

Postoperative outcome of three different procedures for childhood glaucoma.

Clin Ophthalmol 2019 17;13:1-7. Epub 2018 Dec 17.

Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan,

Purpose: To investigate the long-term postoperative outcome of three surgical procedures for childhood glaucoma.

Patients And Methods: In this retrospective study, the patients were divided into a goniotomy group, a trabeculotomy group, and a filtering surgery group, based on the initial surgical procedure. Failure was defined as an IOP ≥21 mmHg with medication at two consecutive visits. Read More

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http://dx.doi.org/10.2147/OPTH.S186929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301729PMC
December 2018
2 Reads

Latanoprostene bunod ophthalmic solution 0.024% in the treatment of open-angle glaucoma: design, development, and place in therapy.

Clin Ophthalmol 2018 20;12:2649-2657. Epub 2018 Dec 20.

Division of Glaucoma, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA,

Latanoprostene bunod (LBN) 0.024%, a modified prostaglandin analog, was approved on November 2, 2017, for the reduction of IOP in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). LBN works by combining the IOP-lowering effects of the prostaglandin analogs (through the uveoscleral pathway) with nitric oxide-induced relaxation of the trabecular meshwork and Schlemm's canal. Read More

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https://www.dovepress.com/latanoprostene-bunod-ophthalmic-so
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http://dx.doi.org/10.2147/OPTH.S156038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304237PMC
December 2018
6 Reads

Impact of light conditions on reading ability following multifocal pseudophakic corrections.

Clin Ophthalmol 2018 14;12:2639-2646. Epub 2018 Dec 14.

Department of Ophthalmology, University Hospital of Alexandroupolis, Alexandroupolis, Greece,

Purpose: To examine the impact of light intensity and temperature on reading performance following bilateral pseudophakic multifocal presbyopic correction.

Patients And Methods: This is a prospective clinic-based trial conducted at the Department of Ophthalmology in the University Hospital of Alexandroupolis, Greece. Three groups of patients were formed (G1: patients with bilateral bifocal implantation, G2: patients with bilateral trifocal implantation, and control group: patients with bilateral pseudophakic monofocal implantation). Read More

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https://www.dovepress.com/impact-of-light-conditions-on-read
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http://dx.doi.org/10.2147/OPTH.S180766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300364PMC
December 2018
6 Reads

Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study.

Clin Ophthalmol 2018 14;12:2629-2636. Epub 2018 Dec 14.

Ophthalmology Department, Paris Nord Val-de-Seine University Hospitals, Hôpital Bretonneau, Tours, France.

Background: Dry eye disease (DED) is characterized by a loss of homeostasis of the tear film. It goes along with ocular symptoms, in which ocular surface inflammation and damage play etiological roles. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory protein found in the tear fluid during conjunctivitis, blepharitis and DED. Read More

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http://dx.doi.org/10.2147/OPTH.S186074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300369PMC
December 2018
2 Reads

Phase III trials examining the efficacy of cetirizine ophthalmic solution 0.24% compared to vehicle for the treatment of allergic conjunctivitis in the conjunctival allergen challenge model.

Clin Ophthalmol 2018 13;12:2617-2628. Epub 2018 Dec 13.

Eyevance Pharmaceuticals, TX, USA,

Purpose: The purpose of these Phase III studies was to evaluate the efficacy and safety of cetirizine ophthalmic solution 0.24% compared with vehicle in the treatment of allergen-induced conjunctivitis using the Ora conjunctival allergen challenge (CAC) model.

Methods: The single-center (Study 1) and multi-center (Study 2), double-masked, randomized, vehicle-controlled, parallel group, CAC studies were conducted over ~5 weeks and four study visits. Read More

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http://dx.doi.org/10.2147/OPTH.S185835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296187PMC
December 2018
2 Reads

Surgical outcomes associated with a sutureless drainage valve implantation procedure in patients with refractory glaucoma.

Clin Ophthalmol 2018 12;12:2607-2615. Epub 2018 Dec 12.

Weill Cornell Medical College, New York, NY, USA,

Purpose: To evaluate the safety and efficacy profile of a sutureless procedure for drainage valve implantation with combined cataract removal and/or endoscopic cyclophotocoagulation (ECP).

Materials And Methods: A retrospective case series study of consecutive surgeries for Ahmed glaucoma valve (AGV; New World Medical) implantation in a 1-year period was analyzed. The surgery was performed using a Tisseel fibrin sealant (Baxter Healthcare Corporation) in place of sutures. Read More

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http://dx.doi.org/10.2147/OPTH.S186369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296183PMC
December 2018
1 Read

Home-based visual field test for glaucoma screening comparison with Humphrey perimeter.

Clin Ophthalmol 2018 12;12:2597-2606. Epub 2018 Dec 12.

1st Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece,

Purpose: To present a home-based visual field examination method using a PC monitor or virtual reality glasses and evaluate the reliability of the method by comparing the results with those of the Humphrey perimeter, in order to assess the possibility of glaucoma screening through the Internet.

Materials And Methods: Software implementing a supra-threshold algorithm for the central 24° (52 points) of visual field at three threshold levels: 1) -4 db, 2) -8 db, and 3) -12 db, from the age-expected sensitivity was used for the purpose of testing. The software uses the web camera as a "virtual photometer" in order to detect room luminosity and allows self-testing using a computer monitor or virtual reality glasses using an Android smartphone with a 6-inch display. Read More

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http://dx.doi.org/10.2147/OPTH.S187832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296209PMC
December 2018
1 Read

Tear protein analysis in presumed congenital alacrima.

Clin Ophthalmol 2018 11;12:2591-2595. Epub 2018 Dec 11.

Department of Ophthalmology, Kyorin University School of Medicine, Tokyo 181-8611, Japan,

Objectives: It is often hard to reach a definitive diagnosis of congenital alacrima because of the difficultly in proving the lack of lacrimal tissue. We report here the distinct tear protein profile in presumed congenital alacrima.

Patients And Methods: A 13-year-old girl with presumed congenital alacrima and 15 healthy volunteers aged 23-35 years were included in this study. Read More

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http://dx.doi.org/10.2147/OPTH.S184207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294164PMC
December 2018
5 Reads

Agreement between retinal images obtained via smartphones and images obtained with retinal cameras or fundoscopic exams - systematic review and meta-analysis.

Clin Ophthalmol 2018 11;12:2581-2589. Epub 2018 Dec 11.

Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil,

Background: Smartphone fundoscopy is a new option for visualizing the ocular fundus but must be validated before being included in population-based examinations. Our aim was to evaluate the quality of fundoscopic images obtained via smartphone and to compare their agreement with retinal camera images or clinical examination.

Methods: The database for this study included all observational studies with smartphone fundoscopy that have comparative analyses with the gold standard methods. Read More

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http://dx.doi.org/10.2147/OPTH.S182022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294162PMC
December 2018
2 Reads

Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study.

Clin Ophthalmol 2018 12;12:2575-2579. Epub 2018 Dec 12.

Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, Egypt,

Aim: To evaluate the effect of oral Difrarel on progression of high myopia in children and to study myopia course after its discontinuation.

Methods: A total of 64 highly myopic children were enrolled in this study. Patients were divided into two equal groups: group 1 was administered Difrarel for 1 year and stopped its intake for another year, and group 2 (control) did not take Difrarel. Read More

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http://dx.doi.org/10.2147/OPTH.S187949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296196PMC
December 2018
1 Read

Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study.

Clin Ophthalmol 2018 6;12:2535-2544. Epub 2018 Dec 6.

Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan,

Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes.

Methods: In 14 eyes of 14 healthy subjects and 22 early-moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Read More

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https://www.dovepress.com/circumpapillary-structure-function
Publisher Site
http://dx.doi.org/10.2147/OPTH.S186739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287771PMC
December 2018
2 Reads

Post-marketing surveillance study of the safety of dexamethasone intravitreal implant in patients with retinal vein occlusion or noninfectious posterior segment uveitis.

Clin Ophthalmol 2018 6;12:2519-2534. Epub 2018 Dec 6.

Allergan Plc, Irvine, CA, USA.

Purpose: To evaluate the long-term safety of dexamethasone intravitreal implant (DEX) in patients treated for macular edema associated with retinal vein occlusion (RVO) or noninfectious posterior segment uveitis (NIPSU) in clinical practice.

Patients And Methods: Multicenter (102 sites in France, Germany, Spain, UK), prospective, observational, post-authorization safety study in adult patients treated with DEX. Data collected up to 2 years after enrollment included serious adverse events (SAEs) and adverse events of special interest (AESIs; adverse drug reactions that are considered important risks associated with DEX and listed in the European Union Ozurdex Risk Management Plan). Read More

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http://dx.doi.org/10.2147/OPTH.S181256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287662PMC
December 2018
7 Reads

Scleral buckle surgery in Ghana: a decade comparison of the anatomic and visual outcome.

Clin Ophthalmol 2018 5;12:2509-2517. Epub 2018 Dec 5.

Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, KAR Campus, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To compare the anatomic and visual outcome of scleral buckle (SB) surgery in Korle Bu Teaching Hospital between 2002 and 2005 and 2011 and 2014.

Materials And Methods: In this retrospective comparative study, the medical records of patients who have undergone SB for rhegmatogenous retinal detachment from January 2002 to December 2005 (group A) and from January 2011 to December 2014 (group B) in Korle Bu Teaching Hospital were examined. The clinical history, surgical techniques, and outcomes of treatment were analyzed. Read More

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https://www.dovepress.com/scleral-buckle-surgery-in-ghana-a-
Publisher Site
http://dx.doi.org/10.2147/OPTH.S184047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287668PMC
December 2018
5 Reads

Efficacy and safety of dual-polymer hydroxypropyl guar- and hyaluronic acid-containing lubricant eyedrops for the management of dry-eye disease: a randomized double-masked clinical study.

Clin Ophthalmol 2018 5;12:2499-2508. Epub 2018 Dec 5.

Quinze-Vingts Hospital, DHU Sight Restore, University Versailles Saint Quentin en Yvelines, INSERM-DHOS CIC, Paris, France.

Background: An artificial-tear formulation containing the dual polymers hydroxypropyl guar (HPG) and hyaluronic acid (HA) is approved for the treatment of dry-eye disease (DED). The present study compared the efficacy and safety of the HPG-HA dual-polymer formulation vs a sodium hyaluronate (SH)-containing artificial-tear formulation in patients with DED.

Methods: In a prospective, 6-week, multicenter, double-masked, parallel-group study, patients with DED aged ≥18 years and total ocular surface staining (TOSS) score ≥4 and ≤9 were randomized (1:1) to receive either HPG-HA or SH four times a day for 42 days. Read More

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http://dx.doi.org/10.2147/OPTH.S177176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287663PMC
December 2018
1 Read

Circumferential viscodilation of Schlemm's canal for open-angle glaucoma: ab-interno vs ab-externo canaloplasty with tensioning suture.

Clin Ophthalmol 2018 5;12:2493-2498. Epub 2018 Dec 5.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To compare the efficacy of minimally invasive ab-interno canaloplasty (ABiC) vs ab-externo canaloplasty (CP) in reducing intraocular pressure (IOP) and glaucoma medication dependence.

Patients And Methods: This nonrandomized, retrospective, single-center, paired eye study assessed the 12-month outcomes of 12 patients with primary open-angle glaucoma who underwent ABiC in one eye and CP in the other eye, either as stand-alone procedures or combined with cataract extraction. Primary endpoints included mean IOP and number of glaucoma medications at 12 months postoperative. Read More

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http://dx.doi.org/10.2147/OPTH.S178962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287658PMC
December 2018
1 Read

The burden of neovascular age-related macular degeneration: a patient's perspective.

Clin Ophthalmol 2018 4;12:2483-2491. Epub 2018 Dec 4.

Sydney Institute of Vision Science, Sydney Retina, Sydney, NSW, Australia,

Purpose: To quantify the burden and quality of life of patients and their caregivers in a cohort of patients with neovascular age-related macular degeneration (nAMD) in an Australian clinical setting.

Methods: A total of 103 patients undergoing anti-vascular endothelial growth factor (VEGF) therapy for nAMD were asked to complete questionnaires relating to the financial and time burdens of nAMD.

Results: All patients completed the questionnaires. Read More

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http://dx.doi.org/10.2147/OPTH.S185052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287411PMC
December 2018
7 Reads

Risk factors and clinical signs of severe keratitis.

Clin Ophthalmol 2018 10;12:2567-2573. Epub 2018 Dec 10.

Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan,

Purpose: To determine risk factors and clinical signs for severe keratitis (AK) by comparing severe cases with mild cases with good prognosis.

Patients And Methods: We reviewed medical records of ten cases of AK (five males and five females) referred to our hospital and classified cases into two groups. One eye that required therapeutic keratoplasty and three eyes with a poor visual acuity (<0. Read More

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http://dx.doi.org/10.2147/OPTH.S179360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292401PMC
December 2018
1 Read

Cost effect of surgeon and patient discretion in regard to cataract surgery.

Clin Ophthalmol 2018 10;12:2563-2565. Epub 2018 Dec 10.

West Virginia University Eye Institute, Department of Ophthalmology, West Virginia University, Morgantown, WV 26506, USA,

Purpose: The purpose of this study is to examine the cost effect of surgeon and patient discretion in regard to cataract surgery and how this affects population health care costs.

Methods: A model of cataract progression was created from preexisting published data and combined with mortality data and Medicare cataract statistics to estimate the effect of mortality on decreasing the rate of cataract surgery if surgery was delayed until any cataract progression occurred.

Results: Five-year cataract progression rates were determined for a given patient age, sex, and type of cataract. Read More

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http://dx.doi.org/10.2147/OPTH.S190184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292396PMC
December 2018
1 Read

Visual function, digital behavior and the vision performance index.

Clin Ophthalmol 2018 10;12:2553-2561. Epub 2018 Dec 10.

Vizzario, Inc., Venice, CA, USA,

Historically, visual acuity has been the benchmark for visual function. It is used to measure therapeutic outcomes for vision-related services, products and interventions. Quantitative measurement of suboptimal visual acuity can potentially be corrected optically with proper refraction in some cases, but in many cases of reduced vision there is something else more serious that can potentially impact other aspects of visual function such as contrast sensitivity, color discrimination, peripheral field of view and higher-order visual processing. Read More

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http://dx.doi.org/10.2147/OPTH.S187131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292403PMC
December 2018
1 Read