3,186 results match your criteria Clinical Ophthalmology[Journal]


Longitudinal changes in dry eye symptoms and signs following lifitegrast therapy and relationship to tear osmolarity.

Clin Ophthalmol 2019 28;13:571-579. Epub 2019 Mar 28.

Eye Care Associates of Nevada, Sparks, NV, USA.

Background: This study measured longitudinal changes in dry eye disease (DED) symptoms and signs following lifitegrast therapy and assessed their relationship to tear osmolarity to test the hypothesis that a decline in tear osmolarity is a reliable leading indicator of subsequent improvement in DED symptoms and signs after initiating lifitegrast treatment.

Methods: This phase IV, prospective, single-arm, open-label, 12-week study enrolled subjects aged ≥18 years with eye dryness score ≥40 (0-100 VAS) and tear osmolarity ≥308 mOsm/L. Subjects were prescribed lifitegrast ophthalmic solution 5%, twice daily in each eye. Read More

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http://dx.doi.org/10.2147/OPTH.S196593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445190PMC

Quality of life after refractive surgery: ReLEx SMILE vs Femto-LASIK.

Clin Ophthalmol 2019 26;13:561-570. Epub 2019 Mar 26.

Krasnodar Branch of Fyodorov Eye Microsurgery, Federal State Institution, Krasnodar, Russia,

Purpose: The safety and effectiveness of complex myopic astigmatism correction using ReLEx SMILE or Femto-LASIK techniques have been well established. The purpose of the current study is to compare quality of life (QoL) outcomes following ReLEx SMILE or Femto-LASIK procedures in parallel with functional vision and anatomic outcomes of treated eyes.

Patients And Methods: This prospective, consecutive series included 118 patients, 18-43 years of age, out of which 56 underwent ReLEx SMILE and 62 underwent Femto-LASIK surgery for correction of myopic astigmatism. Read More

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https://www.dovepress.com/quality-of-life-after-refractive-s
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http://dx.doi.org/10.2147/OPTH.S170277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440445PMC
March 2019
1 Read

Outcome of Descemet membrane endothelial keratoplasty for graft failure after Descemet stripping automated endothelial keratoplasty.

Clin Ophthalmol 2019 25;13:553-559. Epub 2019 Mar 25.

Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany,

Purpose: To investigate the efficacy and safety of Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following primary Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods: This was a retrospective case series of 15 patients that underwent DMEK surgery for corneal decompensation after failed DSAEK. Main outcome parameter was corrected distance visual acuity (CDVA) after DMEK and DSAEK. Read More

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http://dx.doi.org/10.2147/OPTH.S194185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438261PMC

Incidence and management of symptomatic dry eye related to LASIK for myopia, with topical cyclosporine A.

Clin Ophthalmol 2019 25;13:545-552. Epub 2019 Mar 25.

Laservision.gr Clinical and Research Eye Institute, Athens, Greece,

Purpose: To evaluate the incidence of transient dry eye associated with LASIK for myopia and the efficacy of topical cyclosporine A administration.

Methods: Group A was formed from 145 (82 female, 63 male) eyes that developed clinically significant dry eye within 1 month post-LASIK and were subjected to cyclosporine A treatment. A "non-symptomatic for dry eye" and age- and gender-matched group (group B) was formed from the same pool of patients to serve as control. Read More

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http://dx.doi.org/10.2147/OPTH.S188521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438263PMC

A randomized controlled trial of povidone-iodine/dexamethasone ophthalmic suspension for acute viral conjunctivitis.

Clin Ophthalmol 2019 21;13:535-544. Epub 2019 Mar 21.

Ophthalmics, Shire, A Takeda Company, Lexington, MA, USA.

Purpose: To evaluate the clinical safety and efficacy of povidone-iodine (PVP-I) 0.6%/dexamethasone (DEX) 0.1% ophthalmic suspension vs vehicle in patients with clinically suspected acute viral conjunctivitis. Read More

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http://dx.doi.org/10.2147/OPTH.S191275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433103PMC

Outcomes of resident-performed small incision cataract surgery in a university-based practice in the USA.

Clin Ophthalmol 2019 20;13:529-534. Epub 2019 Mar 20.

Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA,

Purpose: To assess outcomes of resident-performed small incision cataract surgery (SICS) at a single academic institute and to determine the availability of SICS-oriented educational resources in residency programs across the USA.

Patients And Methods: A retrospective chart review was conducted on all patients who underwent SICS performed by postgraduate year 4 residents between January 2014 and January 2018 at the Wilmer Eye Institute, Baltimore, MD, USA. Postoperative visual acuity, intraoperative complications, and postoperative complications were the main outcomes measured. Read More

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http://dx.doi.org/10.2147/OPTH.S198870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433105PMC
March 2019
1 Read

Long-term efficacy and safety of infliximab and cyclosporine combination therapy for refractory uveoretinitis in Behçet's disease.

Clin Ophthalmol 2019 20;13:521-527. Epub 2019 Mar 20.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan,

Purpose: This study aimed to evaluate the long-term efficacy and safety of infliximab (IFX) and cyclosporine (CsA) combination therapy for refractory uveoretinitis in Behçet's disease (BD).

Patients And Methods: The study involved a retrospective review of the medical records of 11 patients with Behçet's uveoretinitis refractory to conventional treatment who had been treated with IFX+CsA combination therapy. The frequency of ocular inflammatory attacks and a Behçet's disease ocular attack score 24 (BOS24) were used as indices for the evaluation of efficacy during each 6-month period prior to and following initiation of therapy. Read More

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http://dx.doi.org/10.2147/OPTH.S198648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433110PMC

Long-term outcome of full tendon vertical rectus transposition with Foster suture in unilateral complete sixth cranial nerve palsy.

Clin Ophthalmol 2019 18;13:515-519. Epub 2019 Mar 18.

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,

Purpose: To evaluate the success rate and long-term motor and sensory outcomes of the full tendon vertical rectus transposition (VRT) with Foster suture for unilateral complete sixth cranial nerve palsy.

Patients And Methods: We reviewed the medical records of patients with unilateral acquired sixth cranial nerve palsy who underwent unilateral full tendon VRT with Foster suture between 2005 and 2016 and had a follow-up of ≥2 years. Data on pre- and postoperative diplopia, face turn, ocular deviation, and limitation of abduction were collected. Read More

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http://dx.doi.org/10.2147/OPTH.S193751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429997PMC
March 2019
1 Read

Comparison of head-mounted perimeter (imo) and Humphrey Field Analyzer.

Clin Ophthalmol 2019 14;13:501-513. Epub 2019 Mar 14.

Department of Ophthalmology, Faculty of Medicine Osaka-Sayama City, Kindai University, Osaka, Japan.

Purpose: The head-mounted automated perimeter imo is a new portable perimeter that does not require a dark room and can be used to examine patients in any setting. In this study, imo 24plus (1-2) AIZE examinations were compared with previous Humphrey Field Analyzer (HFA) 30-2 (SITA standard) examinations within the same patient.

Patients And Methods: imo examinations (either head-mounted [i-H] or fixed [i-F] type) were performed in patients with glaucoma or suspected glaucoma who had already experienced HFA five or more times. Read More

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http://dx.doi.org/10.2147/OPTH.S190995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422415PMC
March 2019
2 Reads

One-year outcomes following implantation of second-generation trabecular micro-bypass stents in conjunction with cataract surgery for various types of glaucoma or ocular hypertension: multicenter, multi-surgeon study.

Clin Ophthalmol 2019 13;13:491-499. Epub 2019 Mar 13.

Hunter Cataract & Eye Centre, Sydney, NSW, Australia.

Purpose: To assess the utility and safety of implanting two second-generation trabecular micro-bypass stents following cataract surgery in eyes with mild to advanced glaucoma or ocular hypertension (OHT).

Patients And Methods: Retrospective study of iStentinject trabecular micro-bypass implantation with cataract surgery by five surgeons at five sites in Australia. Eyes had mild to advanced glaucoma (predominantly primary open-angle, appositional angle-closure, or pseudoexfoliative glaucoma) or OHT and cataract requiring surgery. Read More

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http://dx.doi.org/10.2147/OPTH.S187272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420788PMC
March 2019
1 Read

A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome.

Clin Ophthalmol 2019 12;13:483-490. Epub 2019 Mar 12.

Department of Ophthalmology, La Fe Hospital, Valencia, Spain.

Purpose: To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES).

Patients And Methods: This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N=60) were treated with seawater spray (Quinton) five times daily, and another similar group (N=60) were treated with carmellose artificial tears eyedrops (Viscofresh 0. Read More

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http://dx.doi.org/10.2147/OPTH.S185409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419589PMC
March 2019
6 Reads

Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK.

Clin Ophthalmol 2019 7;13:477-482. Epub 2019 Mar 7.

Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany,

Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.

Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Read More

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http://dx.doi.org/10.2147/OPTH.S192424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410749PMC

Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy.

Clin Ophthalmol 2019 5;13:465-475. Epub 2019 Mar 5.

Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel,

Purpose: To determine the pupil response of Best vitelliform macular dystrophy (BVMD) patients for focal blue and red light stimuli presented at 76 test points in a 16.2° visual field (VF) using a chromatic pupilloperimeter.

Methods: An observational study was conducted in 16 participants: 7 BVMD patients with a heterozygous BEST1 mutation and 9 similar-aged controls. Read More

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http://dx.doi.org/10.2147/OPTH.S191486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407903PMC

Monitoring and management of the patient with pseudoexfoliation syndrome: current perspectives.

Clin Ophthalmol 2019 1;13:453-464. Epub 2019 Mar 1.

Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Pseudoexfoliation syndrome (PES) is a complex and age-related systemic disorder characterized by the progressive accumulation and granular deposition of pseudoexfoliative material in various intraocular and extraocular tissues. The diagnosis of PES is so important because it is a major risk factor for complications during cataract surgery and the most frequent cause of secondary glaucoma. In addition to ocular complications, PES is related with numerous systemic abnormalities, for which the list is growing steadily. Read More

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http://dx.doi.org/10.2147/OPTH.S181444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402616PMC

Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study.

Clin Ophthalmol 2019 1;13:445-452. Epub 2019 Mar 1.

Department of Ophthalmology, Centro Hospitalar de São João, Porto, Portugal,

Purpose: To systematically compare the efficacy of transepithelial accelerated corneal collagen crosslinking (TE-ACXL) with conventional corneal collagen crosslinking (C-CXL) in patients with progressive keratoconus.

Methods: Eyes of patients with progressive keratoconus who were treated with C-CXL (3 mW/cm for 30 minutes) were compared with those who underwent TE-ACXL (6 mW/cm for 15 minutes). Best-corrected visual acuity (BCVA), keratometry values, corneal thickness, and topometric indexes were compared before CXL, and at 2 months, 6 months, and 12 months postoperatively. Read More

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http://dx.doi.org/10.2147/OPTH.S189183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402612PMC

Refractive errors among Saudi college students and associated risk factors.

Clin Ophthalmol 2019 27;13:437-443. Epub 2019 Feb 27.

Epidemiology Department, King Fahd Specialist Hospital, Dammam, Saudi Arabia.

Objectives: To determine the prevalence of refractive errors among freshman students of Imam Abdulrahman Bin Faisal University (IAU), and to examine the relationship of near-work activities and outdoor activities with refractive errors.

Methods: A cross-sectional study of 338 freshman students of IAU (162 males, 176 females) was carried out. Students were selected using a simple random sampling technique. Read More

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http://dx.doi.org/10.2147/OPTH.S193213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398403PMC
February 2019

Prevalence of refractive errors in children with retinoblastoma.

Clin Ophthalmol 2019 25;13:431-435. Epub 2019 Feb 25.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL, USA,

Purpose: The main purpose of this study was to investigate refractive errors in children with unilateral and bilateral retinoblastoma (RB).

Methods: An institutional review board-approved consecutive retrospective cohort study was undertaken. Subjects underwent examination under general anesthesia as part of their RB follow-up, which included evaluation by a single pediatric ophthalmologist. Read More

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http://dx.doi.org/10.2147/OPTH.S195145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394233PMC
February 2019

Neural network and logistic regression diagnostic prediction models for giant cell arteritis: development and validation.

Clin Ophthalmol 2019 21;13:421-430. Epub 2019 Feb 21.

Ophthalmology, Harvard University, Boston, MA, USA.

Purpose: To develop and validate neural network (NN) vs logistic regression (LR) diagnostic prediction models in patients with suspected giant cell arteritis (GCA). Design: Multicenter retrospective chart review.

Methods: An audit of consecutive patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at 14 international medical centers. Read More

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http://dx.doi.org/10.2147/OPTH.S193460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388759PMC
February 2019
3 Reads

Novel method for preventing cyclorotation in Ziemer Femto LDV Z8 femtosecond laser-assisted cataract surgery with Verion image-guided system.

Clin Ophthalmol 2019 20;13:415-419. Epub 2019 Feb 20.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan, Republic of China,

Purpose: To investigate the feasibility of a new method involving the use of the Verion image-guided system in preventing cyclorotation during femtosecond laser-assisted cataract surgery (FLACS).

Patients: Our preliminary data included details of 24 consecutive patients. All patients underwent cataract surgery at Universal Eye Center, Zhong-Li, Taiwan, between December 2016 and January 2017. Read More

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http://dx.doi.org/10.2147/OPTH.S177219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387593PMC
February 2019

Safety of cetirizine ophthalmic solution 0.24% for the treatment of allergic conjunctivitis in adult and pediatric subjects.

Clin Ophthalmol 2019 19;13:403-413. Epub 2019 Feb 19.

Eyevance Pharmaceuticals, Fort Worth, TX, USA,

Purpose: The studies reported here aimed to assess the safety and tolerability of cetirizine ophthalmic solution 0.24%, a new topical ophthalmic medication approved by the US Food and Drug Administration for the treatment of ocular itching associated with allergic conjunctivitis.

Patients And Methods: Three clinical studies evaluated cetirizine ophthalmic solution 0. Read More

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http://dx.doi.org/10.2147/OPTH.S186092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387590PMC
February 2019
4 Reads

Comparison of smartphone ophthalmoscopy vs conventional direct ophthalmoscopy as a teaching tool for medical students: the COSMOS study.

Clin Ophthalmol 2019 18;13:391-401. Epub 2019 Feb 18.

Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, CA, USA,

Purpose: To investigate the utility of smartphone ophthalmology for medical students for learning fundoscopy compared with direct ophthalmoscopy.

Methods: After 1 hour of didactic instruction on ophthalmoscopy, second-year medical students in a small group setting were randomized to start training with the direct ophthalmoscope vs smartphone ophthalmoscope and crossed over to the other instrument through the session.

Main Outcome Measures: Ability to visualize the optic nerve and retinal blood vessels in an undilated pupil as well as a survey evaluating ease of use, confidence, and ability to visualize the optic nerve with the two instruments. Read More

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http://dx.doi.org/10.2147/OPTH.S190922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387606PMC
February 2019
1 Read

Evaluation of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury.

Clin Ophthalmol 2019 18;13:383-390. Epub 2019 Feb 18.

Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt,

Purpose: To evaluate the outcome of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury.

Patients And Methods: This was a retrospective case series that included 20 patients who had undergone living related limbal transplantation due to the presence of bilateral severe stem cell deficiency resulting from chemical injury. Medical records of the selected patients were reviewed. Read More

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http://dx.doi.org/10.2147/OPTH.S192316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387598PMC
February 2019
1 Read

Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study.

Clin Ophthalmol 2019 15;13:373-381. Epub 2019 Feb 15.

Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan,

Purpose: To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein occlusion.

Material And Methods: Forty-six eyes of 44 consecutive patients (27 men, 17 women; age range: 55-88 years) were evaluated. All participants initially received a single intravitreal injection of aflibercept (2 mg in 0. Read More

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http://dx.doi.org/10.2147/OPTH.S177506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387600PMC
February 2019

Architecture evaluation of the main clear corneal incisions in femtosecond laser-assisted cataract surgery by optical coherence tomography imaging.

Clin Ophthalmol 2019 14;13:365-372. Epub 2019 Feb 14.

Renato Ambrosio Ophthalmologic Study Center (CEORA), Brasília, Federal District, Brazil,

Purpose: To assess the stability and reliability of femtosecond laser-assisted cataract surgery (FLACS) incisions design and dimensions using anterior segment optical coherence tomography (AS-OCT) imaging.

Setting: Renato Ambrósio Ophthalmologic Study Center from Hospital Oftalmológico de Brasília, Brasília, Brazil.

Design: Prospective nonrandomized controlled case series. Read More

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https://www.dovepress.com/architecture-evaluation-of-the-mai
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http://dx.doi.org/10.2147/OPTH.S184024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387592PMC
February 2019
3 Reads

Primary vitreoretinal lymphoma: prevalence, impact, and management challenges.

Clin Ophthalmol 2019 14;13:353-364. Epub 2019 Feb 14.

Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru - 560010, India,

Primary vitreoretinal lymphoma (PVRL) is a rare and potentially fatal intraocular malignancy. More than half of PVRL cases eventually involve the central nervous system (CNS). PVRL frequently masquerades as chronic uveitis. Read More

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https://www.dovepress.com/primary-vitreoretinal-lymphoma-pre
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http://dx.doi.org/10.2147/OPTH.S159014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387616PMC
February 2019
12 Reads

Five-year outcomes of intravitreal drug therapy for neovascular age-related macular degeneration in eyes with baseline vision 20/60 or better.

Clin Ophthalmol 2019 13;13:347-351. Epub 2019 Feb 13.

Hill Statistical Consulting, Morrison, CO, USA.

Objective: To assess outcomes in treatment-naive eyes with neovascular age-related macular degeneration (nAMD) and good baseline visual acuity (VA) treated using a treat-and-extend (T&E) regimen with intravitreal aflibercept, ranibizumab, or bevacizumab.

Design: Single center, retrospective, observational case series.

Participants: Ninety-one patients (93 eyes) with nAMD and baseline VA ≥20/60 followed for ≥1 year after the first intravitreal injection. Read More

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http://dx.doi.org/10.2147/OPTH.S191170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387604PMC
February 2019

Delivering mobile eye care to underserved communities while providing training in ophthalmology to medical students: experience of the Guerrilla Eye Service.

Clin Ophthalmol 2019 12;13:337-346. Epub 2019 Feb 12.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA,

Objective: The objective of the study was to characterize the population served by the student-led Guerrilla Eye Service (GES), a mobile outreach program that delivers comprehensive ophthalmic care to underserved communities in the greater Pittsburgh area.

Patients And Methods: Patients attending GES missions at a single urban free clinic from 2012 through 2017 were included in this retrospective case series. All patients underwent a comprehensive eye examination at no cost, with referral to a university eye clinic if necessary. Read More

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http://dx.doi.org/10.2147/OPTH.S185692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387608PMC
February 2019

A phase 2 randomized, double-masked, placebo-controlled study of novel nonsystemic kinase inhibitor TOP1630 for the treatment of dry eye disease.

Clin Ophthalmol 2019 12;13:261-275. Epub 2019 Feb 12.

TopiVert Pharma Limited, London, UK,

Purpose: To evaluate the safety and efficacy of topical TOP1630, a novel nonsystemic kinase inhibitor, in dry eye disease (DED).

Patients And Methods: A randomized, double-masked, parallel-group trial of 0.1% TOP1630 ophthalmic solution TID or placebo (vehicle without active drug) was conducted in DED subjects (n=61). Read More

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http://dx.doi.org/10.2147/OPTH.S189039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387610PMC
February 2019
4 Reads

Recurrent corneal erosion: a comprehensive review.

Clin Ophthalmol 2019 11;13:325-335. Epub 2019 Feb 11.

Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA,

Purpose: To comprehensively review the literature regarding recurrent corneal erosion (RCE) and to present treatment options and recommendations for management.

Overview: RCE usually presents with sharp, unilateral pain upon awakening, in an eye with an underlying basement membrane dystrophy, prior ocular trauma, stromal dystrophy or degeneration, or prior surgery for refractive errors, cataracts, or corneal transplantation. Making the correct diagnosis requires a careful slit-lamp examination of both eyes coupled with a high degree of suspicion. Read More

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http://dx.doi.org/10.2147/OPTH.S157430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376883PMC
February 2019
3 Reads

Consensus on the management of astigmatism in cataract surgery.

Clin Ophthalmol 2019 11;13:311-324. Epub 2019 Feb 11.

Cataract service, IMO - Instituto de Moléstias Oculares, São Paulo, Brazil.

This project was aimed at achieving consensus on the management of astigmatism during cataract surgery by ophthalmologists from Latin America using modified Delphi technique. Relevant peer-reviewed literature was identified, and 21 clinical research questions associated with the definition, classification, measurement, and treatment of astigmatism during cataract surgery were formulated. Twenty participants were divided into seven groups, and each group was assigned three questions to which they had to respond in written form, after thoroughly reviewing the literature. Read More

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http://dx.doi.org/10.2147/OPTH.S178277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376888PMC
February 2019

Seven- and eight-year trends in resident and fellow glaucoma surgical experience.

Clin Ophthalmol 2019 8;13:303-309. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA,

Purpose: This study evaluated US resident and fellow glaucoma surgical experience over a 7- and 8-year period, respectively.

Methods: US ophthalmology resident glaucoma case logs from 2009 to 2016 and glaucoma fellow case logs from 2008 to 2016 were reviewed. The number of total, average, median, and minimum cases, along with percentile data for filtering surgery, shunting surgery, and novel procedures were analyzed for year-to-year trends. Read More

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https://www.dovepress.com/seven--and-eight-year-trends-in-re
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http://dx.doi.org/10.2147/OPTH.S185529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371949PMC
February 2019
8 Reads

Wide-angled endoillumination vs traditional scleral buckling surgery for retinal detachment - a comparative study.

Clin Ophthalmol 2019 8;13:287-293. Epub 2019 Feb 8.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel,

Purpose: To evaluate the surgical outcomes of traditional scleral buckling (TSB) compared to chandelier-assisted scleral buckling (CSB) for rhegmatogenous retinal detachment repair.

Patients And Methods: A retrospective interventional comparative case series of 49 eyes that underwent SB procedure. Medical records of 27 and 22 eyes that underwent TSB and CSB surgery, respectively, were evaluated. Read More

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http://dx.doi.org/10.2147/OPTH.S182751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371939PMC
February 2019

Macular vascular density at the superficial capillary plexus using the optical coherence tomography angiography.

Clin Ophthalmol 2019 8;13:295-302. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan,

Purpose: The aim of this study was to assess the effects of age, gender, axial length and retinal thickness on the vascular density in a normal population using the Optovue optical coherence tomography angiography (OCT-A).

Methods: A total of 209 eyes of 209 healthy subjects were scanned using the OCT-A on an outpatient basis. Patients were 20-75 years of age. Read More

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http://dx.doi.org/10.2147/OPTH.S189515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371924PMC
February 2019

Digital ophthalmology in Scotland: benefits to patient care and education.

Clin Ophthalmol 2019 8;13:277-286. Epub 2019 Feb 8.

University of Edinburgh, Edinburgh, UK.

Tackling visual impairment remains an important public health issue. Due to limited resources and the increasing demand on hospital eye services (HES), delivery of quality eye care within the community is essential. Training of clinical ophthalmic specialists and allied health-care professionals in the detection and management of common eye conditions can thus help to reduce the burden of eye disease and improve prognostic outcomes. Read More

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http://dx.doi.org/10.2147/OPTH.S185186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371934PMC
February 2019

Lens anatomy parameters with intraoperative spectral-domain optical coherence tomography in cataractous eyes.

Clin Ophthalmol 2019 4;13:253-260. Epub 2019 Feb 4.

Waring Vision Institute, Charleston, SC, USA.

Purpose: To study correlations of crystalline lens anatomy and position parameters obtained using intraoperative spectral-domain (SD) optical coherence tomography (OCT) in cataract patients.

Methods: This retrospective study evaluated biometry data from 600 eyes of 399 cataract patients (mean age: 69±8.4 years) using intraoperative anterior segment SD-OCT during femtosecond laser-assisted cataract surgery. Read More

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http://dx.doi.org/10.2147/OPTH.S184208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366355PMC
February 2019

Endoscopic vitrectomy in endophthalmitis: initial experience of 33 cases at a tertiary eye care center.

Clin Ophthalmol 2019 5;13:243-251. Epub 2019 Feb 5.

Smt Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad 500034, Telangana, India,

Purpose: To report the presentation and management outcomes of endophthalmitis with endoscopic vitrectomy.

Methods: This is a retrospective interventional case series conducted at a tertiary eye care center in south India. Thirty three eyes of 33 patients were included. Read More

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http://dx.doi.org/10.2147/OPTH.S185716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368127PMC
February 2019

Treatment of large avascular retinal pigment epithelium detachments in age-related macular degeneration with aflibercept, photodynamic therapy, and triamcinolone acetonide.

Clin Ophthalmol 2019 1;13:233-241. Epub 2019 Feb 1.

Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, 7491 Trondheim, Norway,

Purpose: To evaluate the use of aflibercept, triamcinolone acetonide, and photodynamic therapy (PDT) in the treatment of avascular pigment epithelium detachments (aPEDs).

Patients And Methods: Patients with treatment-naïve aPEDs ≥1,500 µm in diameter were randomized to treatment or observation. Treatment consisted of 6 monthly intravitreal injections of aflibercept. Read More

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http://dx.doi.org/10.2147/OPTH.S188315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362940PMC
February 2019
3 Reads

Dry eye disease ranking among common reasons for seeking eye care in a large US claims database.

Clin Ophthalmol 2019 1;13:225-232. Epub 2019 Feb 1.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Objectives: Dry eye disease (DED) is a complex multifactorial condition of the ocular surface characterized by symptoms of ocular discomfort, irritation, and visual disturbance. Data previously reported from this study showed an increase in prevalence and incidence of DED with age and over time. The objective of this study was to compare the ranking of DED prevalence among other ocular conditions that led patients to seek eye care. Read More

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http://dx.doi.org/10.2147/OPTH.S188314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362914PMC
February 2019

Patient-reported severity of dry eye and quality of life in diabetes.

Clin Ophthalmol 2019 25;13:217-224. Epub 2019 Jan 25.

School of Health and Life Sciences, Glasgow Caledonian University (GCU), Glasgow G4 0BA, UK,

Purpose: The purpose of the study was to assess the relationship between patient-reported severity of dry eye disease (DED), quality of life (QoL), presence of diabetic retinopathy (DR) and length of disease duration in people with type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2).

Patients And Methods: A survey of 152 people (110 with and 42 without diabetes). All participants completed the Ocular Surface Disease Index (OSDI) and Dry Eye-related Quality of Life Score (DEQS) questionnaires. Read More

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http://dx.doi.org/10.2147/OPTH.S184173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354694PMC
January 2019

Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019
2 Reads

Surgical experience with a redesigned, fully preloaded, hydrophobic acrylic intraocular lens in challenging cases of pseudoexfoliation syndrome, phacodonesis, and small pupils.

Clin Ophthalmol 2019 22;13:199-206. Epub 2019 Jan 22.

Borkenstein & Borkenstein, Privatklinik der Kreuzschwestern Graz, Graz, Austria,

Purpose: The purpose of this study was to describe our surgical experience and evaluate safety and postoperative outcomes of a fully preloaded, monofocal, hydrophobic acrylic intraocular lens (IOL) (CT LUCIA 611P) with a newly designed optic-haptic junction in severe cases of pseudoexfoliation (PXF) syndrome, phacodonesis, and small pupils.

Setting: This study was conducted in Borkenstein & Borkenstein, private practice, Privatklinik der Kreuzschwestern Graz, Austria.

Patients And Methods: This study presents outcomes of 15 eyes of 15 patients implanted with CT LUCIA 611P IOL with improved optical properties and more rigid and wider optic- haptic junction. Read More

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https://www.dovepress.com/surgical-experience-with-a-redesig
Publisher Site
http://dx.doi.org/10.2147/OPTH.S194420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348969PMC
January 2019
6 Reads

TearCare system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare treatment on subjects with dry eye disease.

Authors:
David Badawi

Clin Ophthalmol 2019 22;13:189-198. Epub 2019 Jan 22.

Clinical Trials Section, Central Eye Care, Arlington Heights, IL, USA,

Purpose: Evaluation of the safety and effectiveness of a TearCare retreatment in adult subjects with clinically significant dry eye disease (DED).

Patients And Methods: This was an extension of an initial 6-month, prospective, single-center, randomized, parallel-group pilot study. In the initial study, subjects with DED were randomized to either a single TearCare treatment or 4 weeks of daily warm compress therapy. Read More

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http://dx.doi.org/10.2147/OPTH.S191588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348966PMC
January 2019

Incidence and prevalence of vitreomacular traction with and without macular hole in Germany.

Clin Ophthalmol 2019 15;13:177-188. Epub 2019 Jan 15.

Department of Ophthalmology, Faculty of Life Course Sciences and Medicine, King's College London, London, UK.

Purpose: Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany.

Materials And Methods: A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies. Read More

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http://dx.doi.org/10.2147/OPTH.S188704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339449PMC
January 2019

Comparing the long-term impact on health care resources utilization and costs due to various single-piece acrylic monofocal intraocular lens implantation during cataract surgery: a cost-consequence analysis for the United Kingdom, Italy, and Denmark.

Clin Ophthalmol 2019 14;13:169-176. Epub 2019 Jan 14.

Patient Access Services, Novartis Healthcare Private Limited, Hyderabad, India.

Purpose: The objective of this study was to estimate the cost impact of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy and its complications due to single-piece acrylic monofocal intraocular lenses (IOLs) in the healthcare setting of United Kingdom, Italy, and Denmark.

Materials And Methods: A hypothetical cost-consequence model was developed to estimate economic burden of Nd:YAG laser capsulotomy due to different single-piece acrylic monofocal IOLs. Cumulative incidence of Nd:YAG laser capsulotomy at 3 years after cataract surgery with five single-piece monofocal acrylic IOLs was sourced from retrospective data analysis of electronic medical records of cataract patients in the United Kingdom. Read More

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http://dx.doi.org/10.2147/OPTH.S190754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338125PMC
January 2019

360° ab-interno trabeculotomy in refractory primary open-angle glaucoma.

Clin Ophthalmol 2019 11;13:161-168. Epub 2019 Jan 11.

University of Oklahoma, Oklahoma City, OK, USA.

Purpose: The purpose of this study was to evaluate the safety and efficacy of microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using the TRAB360 device as a stand-alone procedure in patients with refractory primary open-angle glaucoma (POAG) and preoperative IOP ≥18 mmHg.

Setting: This study evaluated patients treated in a tertiary-referral clinical practice setting.

Design: This study is a retrospective analysis of 81 eyes. Read More

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https://www.dovepress.com/360deg-ab-interno-trabeculotomy-in
Publisher Site
http://dx.doi.org/10.2147/OPTH.S189260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333157PMC
January 2019
4 Reads

Local anesthesia and anxiolytic techniques for oculoplastic surgery.

Clin Ophthalmol 2019 10;13:153-160. Epub 2019 Jan 10.

Department of Anesthesia, Michael Garron Hospital, University of Toronto, Toronto, ON Canada.

This study discusses local anesthetic agents, administration techniques, ancillary considerations, and safety precautions for oculoplastic surgery including eyelid, lacrimal, orbital, and temporal artery biopsy procedures. Methods for reducing patient apprehension and discomfort including systemic premedication, topical pre-anesthetic, visual, auditory and tactile distraction techniques, regional blocks, small gauge needles, warmed lidocaine, and buffered lidocaine are discussed. Read More

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https://www.dovepress.com/local-anesthesia-and-anxiolytic-te
Publisher Site
http://dx.doi.org/10.2147/OPTH.S188790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330983PMC
January 2019
16 Reads

Corneal incision architecture: VICTUS femtosecond laser vs manual keratome.

Clin Ophthalmol 2019 10;13:147-152. Epub 2019 Jan 10.

Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil,

Purpose: To evaluate anatomical differences between laser (VICTUS) and manual constructed phacoemulsification incisions.

Setting: Study was conducted at the Hospital de Olhos Paulista, Sao Paulo, Brazil.

Design: This is a prospective, observational, consecutive nonrandomized cohort. Read More

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https://www.dovepress.com/corneal-incision-architecture-vict
Publisher Site
http://dx.doi.org/10.2147/OPTH.S181144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330980PMC
January 2019
10 Reads

Lamellar macular hole surgery - current concepts, future prospects.

Clin Ophthalmol 2019 8;13:143-146. Epub 2019 Jan 8.

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Lamellar macular holes present distinct morphological features including tractional or non-tractional epimacular membranes, foveal tissue alterations, defects of the outer retinal layers, or a separation of the retinal layers. At present, degenerative lamellar holes are differentiated from tractional holes based on the morphological characteristics seen in OCT. The current treatment approach is based on this gross differentiation. Read More

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http://dx.doi.org/10.2147/OPTH.S188309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329342PMC
January 2019
2 Reads

Long-term safety of posterior chamber implantable phakic contact lens for the correction of myopia.

Clin Ophthalmol 2019 7;13:137-142. Epub 2019 Jan 7.

The Eye Foundation, Coimbatore, India,

Purpose: To review the safety of the implantable phakic contact lens (IPCL V1, Caregroup Sight Solutions, India) for correction of myopia and myopic astigmatism.

Methods: Retrospective interventional case series including 134 eyes which underwent IPCL implantation for correction of myopia and myopic astigmatism at a tertiary eye care hospital in South India. Intraoperative and postoperative complications were analyzed. Read More

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https://www.dovepress.com/long-term-safety-of-posterior-cham
Publisher Site
http://dx.doi.org/10.2147/OPTH.S185304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327895PMC
January 2019
10 Reads