4,621 results match your criteria Clinical Nutrition[Journal]


Acute study of dose-dependent effects of (-)-epicatechin on vascular function in healthy male volunteers: A randomized controlled trial.

Clin Nutr 2019 Apr 9. Epub 2019 Apr 9.

Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, PO Box 226, RG2 6AP, Reading, United Kingdom.

Background & Aims: There is convincing clinical evidence to suggest that flavanol-containing foods/beverages are capable of inducing improvements in human vascular function. However, whilst (-)-epicatechin has been tested for efficacy, a full dose-dependency has yet to be established, particularly at doses below 1 mg/kg BW. The current study examined the dose-dependent effects of (-)-epicatechin on human vascular function with concurrent measurement of plasma (-)-epicatechin metabolites and levels of circulating nitrite and nitrate species, NO. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.041DOI Listing

Omega-3 and omega-6 polyunsaturated fatty acids and metabolic syndrome: A systematic review and meta-analysis.

Clin Nutr 2019 Apr 5. Epub 2019 Apr 5.

Department of Food and Nutrition, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. Electronic address:

Background & Aims: Previous studies suggest that polyunsaturated fatty acids (PUFAs) may reduce the risk of metabolic diseases, but some have shown ambiguous results. The aim of this study was to systematically evaluate and summarize available evidence on the association between omega-3 and omega-6 PUFA levels and risk of metabolic syndrome (MetS).

Methods: A systematic literature search of articles published until December 2017 was conducted in PubMed, Web of Science, and Cochrane Library databases. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.032DOI Listing

Citrulline and muscle protein homeostasis in three different models of hypercatabolism.

Clin Nutr 2019 Apr 4. Epub 2019 Apr 4.

Laboratoire de Biologie de la Nutrition, EA 4466 PRETRAM, Université Paris Descartes, Sorbonne Paris Cité, France; Service de Biochimie, Hôpital Cochin, HUPC, AP-HP, Paris, France. Electronic address:

Supplementation of enteral nutrition (EN) by specific amino acids (AAs) has been proposed to prevent muscle protein loss in intensive care unit (ICU) patients. Citrulline (Cit), which has been shown to stimulate muscle protein synthesis in other situations, may be of interest in this setting. Our aim was to assess the effect of Cit in three catabolic models relevant to critical illness: endotoxemia (LPS), traumatic brain injury (TBI), and TBI with infectious complications (TBI-Ec), which are characterized by different alterations in protein homeostasis. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.036DOI Listing

Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.

Clin Nutr 2019 Apr 4. Epub 2019 Apr 4.

Dept. of Food and Nutrition, Institue of Basic Science, Obesity/Diabetes Research Center, Hoseo University, Asan, Chungnam, 31499, South Korea. Electronic address:

Background & Aims: Low serum HDL cholesterol (HDL-C) concentration is a risk factor for cardiovascular diseases and it is influenced by genetic and environmental factors. We hypothesized that genetic variants that decrease serum HDL-C concentrations may interact with nutrient intakes in ways that increase or decrease the risk of cardiovascular disease.

Methods: Candidate genetic variants that can lower serum HDL-C concentrations were explored by genome-wide association studies (GWAS), after adjusting for covariates, in the Ansan/Ansung cohort (n = 8842) from KoGES. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.039DOI Listing

Pharmacokinetics of omega-3 fatty acids in patients with severe sepsis compared with healthy volunteers: A prospective cohort study.

Clin Nutr 2019 Apr 9. Epub 2019 Apr 9.

University of Vermont Larner College of Medicine, Burlington, VT, USA. Electronic address:

Background: Pharmacokinetics (PK) of pharmaceuticals and pharmaconutrients are poorly understood in critically ill patients, and dosing is often based on healthy subject data. This might be particularly problematic with enteral medications due to metabolic abnormalities and impaired gastrointestinal tract absorption common in critically ill patients. Utilizing enteral fish oil, this study was undertaken to better understand and define PK of enteral omega-3 fatty acids (eicospentaenoic acid [EPA] and docosahexaenoic acid [DHA]) in critically ill patients with severe sepsis. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.040DOI Listing

Children mortality and malnutrition as a global issue.

Clin Nutr 2019 Apr 1. Epub 2019 Apr 1.

Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.03.035DOI Listing
April 2019
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Differential circulating and visceral fat microRNA expression of non-obese and obese subjects.

Clin Nutr 2019 Apr 8. Epub 2019 Apr 8.

Nutrition and Metabolism Research Division, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

Background & Aims: Altered microRNA (miRNA) expression is associated with the pathophysiology of obesity; however, little is known about the miRNAs commonly dysregulated in the blood and visceral fat tissue of obese patients. This study compared the circulating and visceral fat miRNA expression in subjects with and without obesity.

Methods: For the circulating miRNA study, 20 healthy control and 30 obese subjects were recruited. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.033DOI Listing
April 2019
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Nutritional therapy and outcomes in underweight critically ill patients.

Clin Nutr 2019 Apr 5. Epub 2019 Apr 5.

Endocrin Division and Medical Nutrition Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

Background & Aims: Critically ill patients with body mass index (BMI) < 20 kg/m have worse outcomes than normal/overweight patients possibly because underweight is a marker of malnutrition. To assess the effects of nutrition therapy in this population during the first week of an ICU stay.

Methods: Prospective, 2-centre, observational study. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.038DOI Listing
April 2019
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Prevalence and prognostic significance of malnutrition in patients with cancers of the head and neck.

Clin Nutr 2019 Apr 4. Epub 2019 Apr 4.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada. Electronic address:

Background & Aims: Head and neck cancer (HNC) are at high nutritional risk; however the prevalence and severity of malnutrition in contemporary patients with HNC are unclear. Diagnostic criteria for cancer-associated weight loss grading (WLG) (Grades 0 to 4) [1] have been validated and are recommended in oncology nutrition clinical practice guidelines [2-3]. The aim was to determine the prevalence using WLG in HNC patients and determine the extent to which reduced dietary intake (DI) explained variation of WLG. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.030DOI Listing
April 2019
4 Reads

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.

Clin Nutr 2019 Apr 2. Epub 2019 Apr 2.

Nutrition Intensive Care Unit, Hospices Civil de Lyon, F-69495, Pierre Benite Cedex, France. Electronic address:

Background & Aims: Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.037DOI Listing
April 2019
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Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.

Clin Nutr 2019 Mar 25. Epub 2019 Mar 25.

Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Background & Aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).

Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193012
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http://dx.doi.org/10.1016/j.clnu.2019.03.010DOI Listing
March 2019
4 Reads

Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial.

Clin Nutr 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatric Surgery, Seoul National University Children's Hospital, Seoul, Republic of Korea.

Background: Vitamin D inadequacy is associated with a wide range of diseases. However, optimal strategies to improve vitamin D status, especially in Asian populations, remain unclear. We tested the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would be similar in serum 25OHD increases, and (3) the two interventions may have different effects on cardio-metabolic markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193013
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http://dx.doi.org/10.1016/j.clnu.2019.03.021DOI Listing
March 2019
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Weight loss probiotic supplementation effect in overweight and obesity subjects: A review.

Clin Nutr 2019 Apr 3. Epub 2019 Apr 3.

Curso de Nutrição do Centro Universitário São Camilo, São Paulo, SP, Brazil; Brazilian Association of Sport Nutrition, São Paulo, SP, Brazil; Universidade de São Paulo, Programa de Pós-graduação em Nutrição em Saúde Pública, São Paulo, SP, Brazil. Electronic address:

Obese individuals present adverse changes in the diversity and composition of the gut microbiota, leading to alterations in energy balance, lipid metabolism, endocrine disturbances, and low-grade chronic systemic inflammation increases. Probiotic supplementation appears to change gut microbiota by decrease gut permeability, inflammation, and metabolic disorders, creating a promising environment to weight loss. This revision resumes the main findings of probiotic supplementation and weight loss that contributed to building the current background linking changes in gut microbiota profile and with obesity. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.034DOI Listing
April 2019
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High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial.

Clin Nutr 2019 Mar 26. Epub 2019 Mar 26.

Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria; Thyroid Endocrinology Osteoporosis Institute Dobnig Graz, Jakob-Redtenbachergasse 10, 8010, Graz, Austria. Electronic address:

Introduction: Frequent blood donation often leads to iron deficiency and even anemia but appropriate strategies for detection and prevention are currently not mandatory. At the Medical University of Graz, we conducted a single-center prospective clinical trial to compare oral and IV iron supplementation in iron deficient blood donors including Austrian regular whole blood and platelet apheresis donors. We aimed to determine the difference of transferrin saturation between the treatment groups 8-12 weeks iron administration besides other parameters of iron status and blood count. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.025DOI Listing
March 2019
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Role of heat shock protein and cytokine expression as markers of clinical outcomes in Glutamine-supplemented parenteral nutrition in surgical ICU patients.

Clin Nutr 2019 Mar 13. Epub 2019 Mar 13.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, GA 30322, USA; Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA. Electronic address:

Background: Nutrients, such as glutamine (GLN), have been shown to effect levels of a family of protective proteins termed heat shock proteins (HSPs) in experimental and clinical critical illness. HSPs are believed to serve as extracellular inflammatory messengers and intracellular cytoprotective molecules. Extracellular HSP70 (eHSP70) has been termed a chaperokine due to ability to modulate the immune response. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.045DOI Listing
March 2019
1 Read
4.476 Impact Factor

Effects of nutrition and physical exercise intervention in palliative cancer patients.

Clin Nutr 2019 Apr 2. Epub 2019 Apr 2.

University of Health Sciences, Konya Training and Research Hospital, Palliative Care Center and Geriatrics, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.03.031DOI Listing

Postprandial inflammatory responses after oral glucose, lipid and protein challenges: Influence of obesity, sex and polycystic ovary syndrome.

Clin Nutr 2019 Apr 1. Epub 2019 Apr 1.

Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal, Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. Electronic address:

Background & Aims: Most evidence linking the polycystic ovary syndrome (PCOS) with chronic low-grade inflammation has been obtained in the fasting state. We have studied the postprandial inflammatory response to oral glucose, lipid and protein challenges and the possible influences of obesity, sex and PCOS on these responses.

Methods: On alternate days, we submitted 17 women with PCOS (9 non-obese, 8 obese), 17 control women (9 non-obese, 8 obese) and 19 control men (10 non-obese, 9 obese) to isocaloric (300 Kcal) oral macronutrient loads. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.027DOI Listing
April 2019
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Determinants of change in resting energy expenditure in patients with stage III/IV colorectal cancer.

Clin Nutr 2019 Mar 30. Epub 2019 Mar 30.

Department of Agricultural, Food, and Nutritional Science, Faculty of Agricultural, Life, and Environmental Sciences, University of Alberta, Canada. Electronic address:

Background & Aims: Resting energy expenditure (REE) is variable in cancer and might be influenced by changes in tumor burden, systemic inflammation, and body composition. The objective of this study was to assess REE change and the predictors of such in patients with stage III or IV colorectal cancer.

Methods: REE was measured via indirect calorimetry and fat mass and fat-free mass (FFM) were assessed using dual X-ray absorptiometry as part of a unique analysis of two studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193013
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http://dx.doi.org/10.1016/j.clnu.2018.12.038DOI Listing
March 2019
2 Reads

Diet quality in early and mid-childhood in relation to trajectories of growth and body composition.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands. Electronic address:

Background: A balanced diet in childhood is important for growth and development. We aimed to examine associations of overall diet quality in both early and mid-childhood with trajectories of growth and body composition until age 10 years.

Methods: We included 3991 children from the Generation R Study, a population-based, prospective cohort in Rotterdam, the Netherlands. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.017DOI Listing
March 2019
4 Reads

Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Potsdam, Germany. Electronic address:

Background & Aims: Pro-inflammatory biomarkers are well-established contributors to insulin resistance and represent valid targets for diabetes management and prevention. Yet, little is known whether nutrition could play a role in modulating various aspects of immune-inflammatory responses. Our aim is to assess the effect of isocaloric animal and plant protein dietary interventions on selected biomarkers representing various immune-inflammatory pathways. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.019DOI Listing
March 2019
25 Reads
4.476 Impact Factor

Survival and CT defined sarcopenia in patients with intestinal failure on home parenteral support.

Clin Nutr 2019 Mar 19. Epub 2019 Mar 19.

St. Mark's Hospital, Harrow, United Kingdom; Department of Surgery and Cancer, Imperial College, London, United Kingdom. Electronic address:

Background & Aims: Sarcopenia occurs in patients with intestinal failure (IF) and has been associated with poorer survival in several chronic diseases. CT can measure sarcopenia through a L3 skeletal muscle index (LSMI). We aim to describe the prevalence of sarcopenia in a section of our IF population using LSMI, & evaluate the effect of home parenteral support (PS) on LSMI & survival. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.015DOI Listing
March 2019
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A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome.

Clin Nutr 2019 Mar 25. Epub 2019 Mar 25.

IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain; Center for Genomic Regulation (CRG), E-08003 Barcelona, Spain; CIBER of Rare Diseases (CIBERER), E-08003 Barcelona, Spain; The Barcelona Institute of Science and Technology, E-08003 Barcelona, Spain. Electronic address:

Background & Aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical trials with high expectations of success have failed to demonstrate significant improvements. Here we tested epigallocatechin-3-gallate (EGCG) as a treatment option for ameliorating core cognitive and behavioral features in FXS.

Methods: We conducted preclinical studies in Fmr1 knockout mice (Fmr1-/y) using novel object-recognition memory paradigm upon acute EGCG (10 mg/kg) administration. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.028DOI Listing
March 2019
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Definitions, predictors and outcomes of feeding intolerance in critically ill children: A systematic review.

Clin Nutr 2019 Mar 30. Epub 2019 Mar 30.

Intensive Care, Department of Pediatrics and Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address:

Background & Aims: Clinicians and researchers often use feeding intolerance (FI) as main cause for insufficient enteral nutrition (EN). However, there is no uniform definition for FI. A uniform definition is essential for future studies focusing on predictors and outcomes of FI and enteral nutrition. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.026DOI Listing

Vegetarian diet and risk of gout in two separate prospective cohort studies.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Department of Cardiology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan; Department of Internal Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Backgrounds & Aims: Plant-based diets may target multiple pathways in gout pathogenesis (uric acid reduction and anti-inflammation) while improving gout associated cardiometabolic comorbidities. We aim to prospectively examine the relationship between a vegetarian diet and gout, and to explore if this relationship is independent of hyperuricemia.

Methods: We followed 4903 participants in the Tzu Chi Health Study (Cohort1, recruited in 2007-2009) and 9032 participants in the Tzu Chi Vegetarian Study (Cohort2, recruited in 2005) until end of 2014. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.016DOI Listing
March 2019
4 Reads

Obesity and risk of hearing loss: A prospective cohort study.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Mitsui Chemicals, Inc., Tokyo, Japan.

Background & Aims: The existing yet limited prospective studies reported conflicting results about obesity and hearing loss. We investigated the prospective association between obesity and hearing loss in a large-scale Japanese working population, as well as the association between metabolic phenotype and hearing loss.

Methods: The study included 48,549 employees aged 20-64 years and free of hearing loss at baseline. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.020DOI Listing
March 2019
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Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial.

Clin Nutr 2019 Mar 18. Epub 2019 Mar 18.

Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:

Background And Aims: The efficacy of nutritional intervention to enhance short- and long-term outcomes of pulmonary rehabilitation in COPD is still unclear, hence this paper aims to investigate the clinical outcome and cost-effectiveness of a 12-month nutritional intervention strategy in muscle-wasted COPD patients.

Methods: Prior to a 4-month pulmonary rehabilitation programme, 81 muscle-wasted COPD patients (51% males, aged 62.5 ± 0. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.001DOI Listing
March 2019
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The potential use of l-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence.

Clin Nutr 2019 Mar 25. Epub 2019 Mar 25.

Department of Diabetes, Central Clinical School, Monash University, Alfred Centre, Melbourne, VIC, Australia. Electronic address:

According to the World Health Organisation, 70% of all deaths globally can be attributed to chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, respiratory conditions, cardiovascular diseases, diabetes and cancer. Chronic inflammation has a significant impact on the quality of life of affected individuals with an increased risk of developing other chronic inflammatory diseases. Given the limitations of current pharmaceuticals, there is an intense research interest in identifying novel dietary interventions that can regulate and alleviate inflammation. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.022DOI Listing
March 2019
2 Reads

Dietary intake and serum levels of trans fatty acids and risk of breast cancer: A systematic review and dose-response meta-analysis of prospective studies.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular - Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background & Aims: Although the relationship between dietary intake and serum levels of trans fatty acids and risk of breast cancer has been investigated extensively, findings are inconsistent. To summarize earlier findings on the association of dietary intake and serum levels of trans fatty acids with risk of breast cancer through a dose-response meta-analysis.

Methods: The online databases of PubMed, ISI Web of Science, Scopus, ProQuest, Science Direct and Embase were searched for relevant publications up to June 2018, using MeSH and non-MeSH keywords. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.024DOI Listing
March 2019
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Nutrient adequacy and diet quality in a Mediterranean population with metabolic syndrome: A cross-sectional study.

Clin Nutr 2019 Mar 21. Epub 2019 Mar 21.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Spain; Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain. Electronic address:

Background & Aims: Few studies have compared micronutrient intake and fulfilment of average requirements (EAR) in non-diabetic, pre-diabetic and diabetic adults at high cardiovascular risk. We assessed these variables in a large sample of participants in the PREDIMED-PLUS randomized trial of primary cardiovascular prevention with diet and physical activity.

Design: Baseline assessment of nutritional adequacy in n = 5792 men and women, aged 55-75 years, with overweight/obesity and some metabolic syndrome features. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.018DOI Listing
March 2019
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Anorexia nervosa: Gut microbiota-immune-brain interactions.

Clin Nutr 2019 Mar 23. Epub 2019 Mar 23.

Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, Prague 4, Czech Republic.

Anorexia nervosa is a psychiatric disorder defined by an extremely low body weight, a devastating fear of weight gain, and body image disturbance, however the etiopathogenesis remains unclear. The objective of the article is to provide a comprehensive review on the potential role of gut microbiota in pathogenesis of anorexia nervosa. Recent advances in sequencing techniques used for microbial detection revealed that this disease is associated with disruption of the composition of normal gut microbiota (dysbiosis), manifested by low microbial diversity and taxonomic differences as compared to healthy individuals. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.023DOI Listing
March 2019
4 Reads

Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells.

Clin Nutr 2019 Mar 19. Epub 2019 Mar 19.

Endocrine, Metabolic and Bariatric Surgery Unit (EAC-BS Center of Excellence), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

Background & Aims: Peripheral white blood cells (PWBC) may allow for the development of obesity biomarkers. We aimed to investigate the existence of gene expression and DNA methylation changes in PWBC after a very low calorie diet (VLCD) followed by a laparoscopic sleeve gastrectomy (LSG), and its correlation with surgical outcomes.

Methods: From July 2013 to June 2014, 35 consecutive bariatric patients and 33 healthy lean volunteers were recruited. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.012DOI Listing
March 2019
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Effects of vitamin D supplementation on metabolic and endocrine parameters in healthy premenopausal women: A randomized controlled trial.

Clin Nutr 2019 Mar 20. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address:

Background & Aims: Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc). Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.007DOI Listing

Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial.

Clin Nutr 2019 Mar 20. Epub 2019 Mar 20.

Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Spain.

Background: There is no established insulin regimen in T2DM patients receiving parenteral nutrition.

Aims: To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN.

Design: Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.036DOI Listing

Effects of inorganic nitrate and vitamin C co-supplementation on blood pressure and vascular function in younger and older healthy adults: A randomised double-blind crossover trial.

Clin Nutr 2019 Mar 20. Epub 2019 Mar 20.

Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom; School of Life Sciences, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

Background: Vitamin C and inorganic nitrate have been linked to enhanced nitric oxide (NO) production and reduced oxidative stress. Vitamin C may also enhance the conversion of nitrite into NO.

Aims: We investigated the potential acute effects of vitamin C and inorganic nitrate co-supplementation on blood pressure (BP) and peripheral vascular function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193011
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http://dx.doi.org/10.1016/j.clnu.2019.03.006DOI Listing
March 2019
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Prognostic significance of sarcopenia and skeletal muscle mass change during preoperative chemoradiotherapy in locally advanced rectal cancer.

Clin Nutr 2019 Mar 19. Epub 2019 Mar 19.

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Background: The aim of this study was to investigate the prognostic impact of sarcopenia and skeletal muscle change in rectal cancer patients who underwent preoperative chemoradiotherapy (preop-CRT).

Material And Methods: From April 2004 to June 2013, we identified non-metastatic rectal cancer patients who underwent preop-CRT. Sarcopenia was evaluated according to previous cut-off value by computed tomography measured before starting preop-CRT (sarcopenia_pre) and 4-6 weeks after cessation of preop-CRT (sarcopenia_post). Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.014DOI Listing

Identification of sub-groups that may be harmed or benefit from higher energy intake.

Clin Nutr 2019 Mar 19. Epub 2019 Mar 19.

Department of Anesthesiology, Faculty of Medicine, University of Malaya, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.03.011DOI Listing

Comment on 2018 ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium.

Authors:
Viola Christmann

Clin Nutr 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatrics, Subdivision of Neonatology, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.03.013DOI Listing

Nutritional status following One Anastomosis Gastric Bypass.

Clin Nutr 2019 Mar 15. Epub 2019 Mar 15.

Department of Nutrition, Assuta Medical Center, Tel-Aviv, Israel. Electronic address:

Background & Aims: One Anastomosis Gastric Bypass (OAGB) has been accepted as an effective treatment for morbid obesity. However, data are scarce regarding nutritional implications of this procedure. Thus, our aim was to describe the health and nutritional status 12-20 months following OAGB surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193012
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http://dx.doi.org/10.1016/j.clnu.2019.03.008DOI Listing
March 2019
3 Reads
4.476 Impact Factor

Fatty liver index (FLI) and prediction of new cases of non-alcoholic fatty liver disease: A population-based study of northern Iran.

Clin Nutr 2019 Mar 18. Epub 2019 Mar 18.

Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: Non-alcoholic fatty liver disease is considered a major public health concern. The prediction of individuals who can acquire this disease would be valuable. The fatty liver index (FLI) is a non-invasive approach that has shown a good capability for discriminating individuals with non-alcoholic fatty liver disease (NAFLD) from those without it. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193007
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http://dx.doi.org/10.1016/j.clnu.2019.02.024DOI Listing
March 2019
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Consumption of eggs and the 15-year incidence of age-related macular degeneration.

Clin Nutr 2019 Mar 16. Epub 2019 Mar 16.

Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, NSW, Australia.

Background And Aims: A naturally rich source of lutein and zeaxanthin are eggs. There is scarce epidemiological data on the temporal association between total egg consumption and age-related macular degeneration (AMD) incidence. We aimed to establish the prospective and independent association between consumption of eggs with the incidence of AMD over a 15-year follow-up. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.009DOI Listing

Omega-3 supplement use, fish intake, and risk of non-fatal coronary artery disease and ischemic stroke in the Million Veteran Program.

Clin Nutr 2019 Mar 13. Epub 2019 Mar 13.

Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background & Aims: Observational and clinical trial evidence suggests an inverse association of omega-3 polyunsaturated fatty acids with coronary artery disease (CAD) mortality, although relationships with non-fatal CAD and stroke are less clear. We investigated whether omega-3 fatty acid supplement use and fish intake were associated with incident non-fatal CAD and ischemic stroke among US Veterans.

Methods: The Million Veteran Program (MVP) is an ongoing nation-wide longitudinal cohort study of US Veterans with self-reported survey, biospecimen, and electronic health record data. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.005DOI Listing

A systematic scoping review of interventions to improve appropriate prescribing of oral nutritional supplements in primary care.

Clin Nutr 2019 Mar 14. Epub 2019 Mar 14.

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland.

Background & Aims: Oral nutritional supplements (ONS) are commonly used to treat malnutrition. Many patients are prescribed ONS without assessment of nutritional status. This conflicts with prescribing guidelines and has considerable cost implications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193011
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http://dx.doi.org/10.1016/j.clnu.2019.03.003DOI Listing
March 2019
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Effects of omega-3 polyunsaturated fatty acid intake in patients with chronic kidney disease: Systematic review and meta-analysis of randomized controlled trials.

Clin Nutr 2019 Mar 14. Epub 2019 Mar 14.

Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Edward Ford Building A27, NSW 2006, Australia; Diaverum Medical-Scientific Office, Trollebergsvagen 2-4, 222 29 Lund, Sweden; Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare, 70124 Bari, Italy; Diaverum Academy, Via Solarino 5, Bari 70124, Italy. Electronic address:

Background & Aims: Dietary and supplemental long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) have shown vascular benefits for the general population, but effects among people with chronic kidney disease (CKD) are largely uncertain. We aimed to evaluate the effects of n-3 PUFA intake among patients with CKD.

Methods: We searched MEDLINE, Embase, and CENTRAL through January 12, 2018. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.041DOI Listing
March 2019
1 Read

Sarcopenia index: More than an marker of muscle mass.

Clin Nutr 2019 Mar 13. Epub 2019 Mar 13.

Hospital Sierrrallana, Servicio de Anestesiología, Spain.

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http://dx.doi.org/10.1016/j.clnu.2019.02.043DOI Listing

Nutritional interest of dietary fiber and prebiotics in obesity: Lessons from the MyNewGut consortium.

Clin Nutr 2019 Mar 9. Epub 2019 Mar 9.

Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.

The aim of EU project MyNewGut is to contribute to future public health-related recommendations supported by new insight in gut microbiome and nutrition-host relationship. In this Opinion Paper, we first revisit the concept of dietary fiber, taking into account their interaction with the gut microbiota. This paper also summarizes the main effects of dietary fibers with prebiotic properties in intervention studies in humans, with a particular emphasis on the effects of arabinoxylans and arabinoxylo-oligosaccharides on metabolic alterations associated with obesity. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.002DOI Listing
March 2019
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Nutritional red flags in children with cerebral palsy.

Clin Nutr 2019 Mar 8. Epub 2019 Mar 8.

Pediatric Endocrinology, KidZ Health Castle, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Background & Aims: Children with cerebral palsy (CP) are at risk for under-nutrition. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines identified anthropometric nutritional red flags for neurologically impaired children: weight for age z-score (WFA) < -2, triceps skinfold (TSF) or arm muscle area (AMA) < 10th centile and faltering weight. This study aimed to (1) evaluate the nutritional status of Flemish children and adolescents with CP using different anthropometric indicators; (2) assess the prevalence of nutritional red flags and (3) identify risk factors for low anthropometric parameters. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.040DOI Listing
March 2019
1 Read
4.476 Impact Factor

Reply to letter regarding: "Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers".

Authors:
Erin F Barreto

Clin Nutr 2019 Mar 14. Epub 2019 Mar 14.

Department of Pharmacy, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.02.044DOI Listing