12,459 results match your criteria Clinical Nuclear Medicine[Journal]


Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecologic Oncology-Hospital Sírio-Libanês, São Paulo, Brazil.

Leiomyomas are prevalent benign smooth muscle tumors in the uterus, displaying variable degrees of FDG uptake on PET/CT. The glucose metabolism intensity of those lesions relies on biologic features and markedly increased FDG accumulation is more typically related to malignant diseases, as in the case of leiomyosarcomas. Notwithstanding that uterine fibroids typically exhibit mild to moderate FDG uptake, in this article we report a case of unexpectedly intense hypermetabolism of a benign uterine leiomyoma on a PET/CT scan performed for initial staging of a breast cancer patient. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002580DOI Listing
April 2019
3 Reads

18F-FDG PET/CT for Staging and Evaluation of Therapy in a Patient With Unusual Hairy Cell Leukemia Presentation.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Hematology, University Medical Centre Ljubljana, Slovenia.

Hairy cell leukemia is a rare hematologic malignancy characterized by splenomegaly, pancytopenia, and susceptibility to infections. We report a case of a 66-year-old man, diagnosed with hairy cell leukemia, without severe cytopenias and splenomegaly, but with an extensive pathological retroperitoneal mass and infiltration of the spleen and skeletal involvement. All findings were highly avid on pretreatment F-FDG PET/CT scan. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002557DOI Listing
April 2019
1 Read

Thyroid Incidentaloma on 18F-fluorocholine PET/CT and 68Ga-PSMA PET/CT Revealing a Medullary Thyroid Carcinoma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Tenon Hospital, AP-HP, Paris, France.

A 66-year-old man with prostate cancer underwent F-fluorocholine PET/CT and thereafter Ga-labeled prostate-specific membrane antigen PET/CT to explore a rising prostate-specific antigen level. Both PET/CT studies showed a thyroid incidentaloma of the right lobe. Neck ultrasound confirmed the presence of a 16-mm right thyroid nodule. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002559DOI Listing
April 2019
1 Read

Typical and Atypical 18FDG PET/CT Findings in Two Cases of Cat Scratch Disease.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Shanghai Universal Medical Imaging Diagnostic Center, Shanghai, China.

Cat scratch disease (CSD) is a rare zoonotic infection disease, and the imaging performance for evaluation varies. We present FDG PET/CT images of two cases of CSD. In one case, images showed typical findings of regional lymph node enlargement. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002558DOI Listing
April 2019
3 Reads
3.931 Impact Factor

Intradermal-Stress-Lymphoscintigraphy in Early Detection and Clinical Management of Secondary Lymphedema: A Pictorial Essay.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Centre for Surgical Treatment of Lymphedema, Plastic Surgery Department, Agostino Gemelli Hospital, Cattolica del Sacro Cuore University, Rome.

Stress-lymphoscintigraphy evaluates the effects of exercise on lymph drainage. Results may predict outcomes of complex physical therapy as a first-line lymphedema treatment. Microsurgical approaches are best in patients with lymphangectasia or dermal backflow. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002560DOI Listing
April 2019
1 Read

First Experience With 177Lu-PSMA-617 Therapy for Advanced Prostate Cancer in the Netherlands.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Nuclear Medicine.

Purpose: The present study summarizes the first experience with Lu-PSMA-617 (Lu-PSMA) treatment in metastatic castration-resistant prostate cancer (PCa) in our institution.

Methods: This was an analysis of the first 30 consecutive patients who underwent Lu-PSMA therapy. Biochemical response was defined as prostate-specific antigen decrease of 50% or greater. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002561DOI Listing
April 2019
1 Read

Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis: An Autopsy-Confirmed Case.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

An 86-year-old woman with cognitive impairment and left hemiparesis underwent F-THK5351 PET 4 months before her death. In addition to "normal" off-target binding in the basal ganglia, abnormal accumulation was observed along the pyramidal tract and around the right basal ganglia as ring-shaped uptake that overlapped a gadolinium-enhanced lesion. Postmortem pathological examination revealed that she had glioblastoma multiforme with associated gliosis, in which monoamine oxidase B (MAO-B) activity is increased. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002564DOI Listing

68Ga-Prostate-Specific Membrane Antigen PET/CT in Cholangiocarcinoma: A Potential Biomarker for Targeted Radioligand Therapy?

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Ga-PSMA is a promising tracer for both staging and detection of biochemical recurrence in prostate cancer. Prostate-specific membrane antigen is also expressed in the endothelium of neovasculature of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of 75-year-old man with metastatic cholangiocarcinoma to liver and lymph nodes progressing on chemotherapy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002563DOI Listing
April 2019
1 Read

68Ga DOTATATE PET/CT Versus 18F-FDG PET/CT for Detecting Intramedullary Hemangioblastoma in a Patient With Von Hippel-Lindau Disease.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nuclear Medicine & Molecular Imaging Department, Imam Reza International University, Mashhad, Iran.

Von Hippel-Lindau disease is an inherited syndrome associated with several benign and malignant tumors such as central nervous system (CNS) hemangioblastoma. Herein, we report a known case of A Von Hippel-Lindau patient with a cerebral hemangioblastoma who was referred for further evaluation because of recent paraparesis. F-FDG PET/CT showed no focal uptake in the thoracic spine, which demonstrated increased Ga DOTATATE activity, owing to overexpression of somatostatin receptors, suggesting spinal cord hemangioblastoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002565DOI Listing
April 2019
1 Read

Gated Tomographic Radionuclide Angiography Using CZT Gamma Camera in Patients Receiving Cardiotoxic Chemotherapy: Going Faster and Less Irradiating.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Nuclear Medicine Department, and.

Tomographic radionuclide angiography (TRNA) can monitor cardiac function in patients receiving cardiotoxic chemotherapy. Gamma cameras using CZT detectors enable dose reduction and quicker acquisitions. We report 80 patients who underwent a 7-minute TRNA acquisition after injection of 550-MBq Tc-labeled human serum albumin. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002569DOI Listing

Avid 68Ga-PSMA Uptake in Accessory Submandibular Salivary Gland.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.

Accessory submandibular salivary gland (ASSG) is an extremely rare variation of the submandibular salivary gland. We reported a 65-year-old man with prostate cancer underwent Ga-PSMA PET/CT for active surveillance. The images showed abnormal PSMA uptake adjacent to the submandibular salivary gland without abnormal activity distribution in the rest regions of the body. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002570DOI Listing
April 2019
1 Read

Osteoporosis Circumscripta on 68Ga-DOTATATE PET CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Nuclear Medicine Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.

Incidental findings on PET CT studies are common. The distribution of Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis circumscripta is the early lytic phase of Paget disease associated with well-defined osteopenia, most commonly seen within the skull on imaging. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002567DOI Listing
April 2019
4 Reads

FDG PET/CT of Spinal Brucellosis.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

A 17-year-old adolescent boy's known case of classical seminoma stage IB for which he underwent right radical orchiectomy. At the first-year follow-up, CT abdomen and pelvis was performed and showed lytic vertebral lesion with left paravertebral necrotic mass that warranted further investigation to exclude disease recurrence. FDG PET/CT scan was performed to evaluate the extent of disease and showed high uptake in the same areas. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002566DOI Listing
April 2019
2 Reads

Postchemotherapy Histiocyte-Rich Pseudotumor of the Spleen Simulating Residual Disease in a Patient With Non-Hodgkin Lymphoma on FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

the Department of Hematology, Soroka University Medical Center, Beer-Sheva, Israel. Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences.

A 64-year-old man was treated with multiagent chemotherapy owing to high-grade non-Hodgkin lymphoma presenting as a bulky disease involving the spleen. Interim and posttreatment sequential FDG PET/CT scans revealed a residual splenic mass showing markedly intense FDG uptake suspected of a residual viable lymphoma. To definitely decide about the appropriate treatment, a laparoscopic splenectomy was performed. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002568DOI Listing
April 2019
1 Read

Triple Ectopic Thyroid Detected on SPECT/CT: A Rare Case Report.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

ENT, All India Institute of Medical Sciences, Bhubaneswar, India.

Ectopic thyroid tissue is a rare entity of embryological aberration along the tract of descend of thyroid gland. Accurate localization and characterization are required for deciding management based on clinical features and symptoms. Ectopic thyroid in the absence of normal thyroid gland is uncommon. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002571DOI Listing

Ureteral Stone Mimicking Abnormal Sacral Uptake on 99mTc MDP Bone Scintigraphy: The Usefulness of SPECT/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Department of Nuclear Medicine, China-Japan Union Hospital, Changchun, Jilin, China.

Bone tracer uptake related to ureteral stones has been reported several times before. We present a right ureteral stone mimicking abnormal focal sacral uptake on planar scan in a patient with rectal cancer. This case highlights the necessity of performing SPECT/CT to ascertain the origin of abnormal focal sacral uptake on planar scan, especially in patients with a history of kidney stones. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002576DOI Listing

Isolated Vaginal Recurrence of Early-Stage Rectal Cancer Detected by 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Chongqing Three Gorges Central Hospital, Chongqing, China.

The relapses of rectal cancer are most frequently localized in the pelvis, liver, and pelvic and para-aortic lymph nodes and lungs, whereas the vagina is an unusual site. We present here a 60-year-old woman presenting with lower abdominal discomfort 23 months after radical resection of rectal adenocarcinoma. An isolated, solitary, hypermetabolic mass in the right part of the vagina was detected by F-FDG PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002573DOI Listing
April 2019
1 Read

68Ga CXCR-4 PET/CT Imaging in an Atypical Case of Extramedullary Plasmacytoma Mimicking as Renal Cell Carcinoma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nephrology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Multiple-myeloma (MM) is a malignant plasma cell proliferation disorder and the second most common blood malignancy after non-Hodgkin lymphoma. The chemokine (CXCR-4) receptor analogues are the newer agents being postulated for myeloma imaging and have shown good diagnostic performance. We report a case of plasmacytoma with suspicious renal cell carcinoma, in whom Ga CXCR-4 PET/CT revealed tracer-avid lesion in the left perinephric region. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002574DOI Listing
April 2019
1 Read

Incidental Primary Breast Lymphoma on 99mTc-Sestamibi Myocardial Perfusion Imaging with SPECT/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of PET Center, Xiangya Hospital, Central South University, Changsha, China.

We present a 53-year-old woman who had shortness of breath and atypical chest pain and underwent Tc-sestamibi myocardial perfusion imaging to detect coronary artery disease. The raw data in cine format showed an incidental focus close to the heart, and SPECT/CT fused images revealed a focus of intense uptake in the left breast. The subsequent histopathologic findings and F-FDG PET/CT imaging confirmed the diagnosis as primary breast lymphoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002572DOI Listing

Pretherapeutic 68Ga-PSMA-617 PET May Indicate the Dosimetry of 177Lu-PSMA-617 and 177Lu-EB-PSMA-617 in Main Organs and Tumor Lesions.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD.

Aim: Combined Ga-PSMA-617 PET imaging and Lu-PSMA-617 therapy is a precise targeted theranostic approach for patients with metastatic castration-resistant prostate cancer (mCRPC). The purpose of this study was to determine whether pretherapeutic standard uptake value (SUV) in Ga-PSMA-617 PET could indicate the effective dose in the main organs and absorbed dose in tumor lesions.

Methods: After institutional review board approval and informed consent, 9 patients with mCRPC were recruited and underwent Ga-PSMA-617 PET/CT scans. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002575DOI Listing
April 2019
1 Read

EnsurePlus as an Alternative to the Standardized Egg Gastric-Emptying Meal.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: The purpose of this study was to establish normal gastric-emptying values for EnsurePlus in healthy subjects and to determine whether it is an acceptable alternative to the recommended standardized Tc-sulfur colloid egg meal.

Methods: Twenty-one healthy subjects underwent gastric-emptying scintigraphy with In-DTPA EnsurePlus. Normal gastric emptying values were established for 1, 2, 3, and 4 hours after meal ingestion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002553DOI Listing

Incidental Uptake in Benign Gynecomastia on 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Breast Imaging and.

A 54-year-old man with mesenteric carcinoid tumor metastatic to the liver completed staging Ga-DOTATATE PET/CT demonstrating uptake in multiple hepatic lesions consistent with liver metastases with additional asymmetric increased uptake in the right greater than the left breast. Subsequent bilateral diagnostic mammogram revealed benign right greater than left gynecomastia without suspicious underlying mass. With Food and Drug Administration approval of Ga-DOTATATE and the increased use of this analog in neuroendocrine tumor imaging, this case illustrates a relevant example of uptake that can potentially mimic malignancy. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9715
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http://dx.doi.org/10.1097/RLU.0000000000002597DOI Listing
April 2019
4 Reads

Use of Static Imaging as a Substitute for Conventional Dynamic Imaging for Salivagrams in Children.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Department of Nuclear Medicine, Children's Hospital of Fudan University, Shanghai, China.

Objective: Salivagrams are commonly used for detecting pulmonary aspiration. However, conventional dynamic imaging is relatively time-consuming and could be difficult to perform in children with poor compliance. We analyzed the characteristics of conventional dynamic imaging to obtain a simple protocol suitable for use in children. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002595DOI Listing

False-Positive 68Ga-DOTATATE PET/CT in Active Chronic Prostatitis.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Urology Department, Kanuni Sultan Suleyman Research and Training Hospital, Health Sciences University, Istanbul, Turkey.

A 66-year-old man with neuroendocrine tumor originating from midgut was referred to Ga-DOTATATE PET/CT imaging for restaging postoperatively. No suspicious uptake regarding residual primary tumoral involvement was seen. But there was diffuse high uptake in prostate gland suggestive of prostatitis or secondary primary tumoral lesion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002594DOI Listing
April 2019
2 Reads

Incidental Detection of a Radiation-Induced Soft-Tissue Sarcoma on 68Ga-PSMA PET/CT in a Patient Previously Treated for Prostate Cancer.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Radiation-induced sarcoma is a rare complication of radiation therapy. We describe the incidental detection of a radiation-induced undifferentiated soft-tissue sarcoma with increased uptake on Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT in a prostate cancer patient previously treated with surgery and external-beam radiotherapy. Results were confirmed by histological analysis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002592DOI Listing
April 2019
2 Reads

An Unusual False-Positive Uptake of Radioiodine Caused by Metallic Implants.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Nuclear Medicine.

A 36-year-old woman with a history of papillary thyroid cancer underwent radioiodine remnant ablation using I. Postablation whole body I scintigraphy revealed increased activity not only in the thyroid bed but also in the right upper thigh. SPECT/CT images localized the activity to the metallic implants of the right femur, implanted 3 years earlier after the right femoral cyst resection. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002587DOI Listing
April 2019
2 Reads

18F-FDG PET/CT in a Case of Metastatic Breast Cancer to the Vulva.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Clinic of Obstetrics and Gynaecology.

A 56-year-old woman, previously treated for breast cancer, presented to gynecologists with a lump of the left labium major of the vulva. The FDG pattern resembled as a cIV stage vulvar cancer, whereas biopsy indicated metastases from breast cancer. Metastatic disease to the vulva is particularly uncommon, representing 5% to 8% of all vulvar cancer lesions. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002583DOI Listing

68Ga-NOTA-Evans Blue TOF PET/MR Lymphoscintigraphy Evaluation of the Severity of Lower Limb Lymphedema.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD.

Purpose: This study was designed to investigate the role of Ga-NOTA-Evans Blue (NEB) time-of-flight (TOF) PET/MR in evaluating lower limb lymphedema by visual analysis and novel parameters.

Methods: Thirteen patients with unilateral lower limb lymphedema were divided into 3 groups according to the clinical severity: minimal (4 patients), moderate (5 patients), and severe (4 patients). All patients underwent Ga-NEB TOF PET/MR lymphoscintigraphy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002584DOI Listing
April 2019
1 Read

Clinical Application of 18F-AlF-NOTA-Octreotide PET/CT in Combination With 18F-FDG PET/CT for Imaging Neuroendocrine Neoplasms.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Objectives: The study is to evaluate biodistribution, dosimetry, safety, and clinical usefulness of F-AlF-NOTA-octreotide (F-OC) PET/CT in combination with F-FDG PET/CT for detection of neuroendocrine neoplasms (NENs).

Methods: The biodistribution, dosimetry, and safety of F-OC were evaluated in 3 healthy volunteers. Twenty-two NEN patients underwent PET/CT at 60 minutes after intravenous injection of 3. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9714
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http://dx.doi.org/10.1097/RLU.0000000000002578DOI Listing
April 2019
1 Read

Comparison of L-Methyl-11C-Methionine PET With Magnetic Resonance Spectroscopy in Detecting Newly Diagnosed Glioma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nuclear Medicine Unit, Department of Imaging and Clinical Pathology, Rovigo, Italy.

Aims: Amino acid PET and magnetic resonance spectroscopy (MRS) are at the forefront of noninvasive imaging techniques used for detection and subtyping of glioma-suspicious lesions. In this pilot study, we compare L-methyl-C-methionine PET and MRS for their ability to predict glioma subtypes.

Methods: Nineteen patients with histologically, confirmed newly diagnosed glioma underwent preoperative L-methyl-C-methionine PET and MRS in 1 diagnostic session. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002577DOI Listing

Asymptomatic Prostate Cancer Brain Metastases on 68Ga-PSMA PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

Brain metastases from prostate cancer are rare and occur at a late stage in the natural history of the disease. Men usually present with neurological manifestations. We present a 66-year-old asymptomatic man who had incidental brain metastases detected on Ga-PSMA PET/CT, which was later confirmed on biopsy to be prostate adenocarcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002548DOI Listing

A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Nuclear Medicine and.

Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002538DOI Listing
April 2019
3 Reads

Hibernoma Demonstrated on 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

A 60-year-old woman with recently diagnosed neuroendocrine tumors underwent staging Ga-DOTATATE PET/CT, which revealed focal uptake within the right sacral ala. Histopathology of the right sacral ala confirmed hibernoma. This case illustrates that hibernoma can be a cause of false-positive intraosseous accumulation of Ga-DOTATATE. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002562DOI Listing

18F-Prostate-Specific Membrane Antigen 1007 and 18F-FCH PET/CT in Local Recurrence of Prostate Cancer.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Affidea Mazovian PET/CT Centre, Warsaw, Poland.

F-prostate-specific membrane antigen (PSMA) 1007 is one of the most promising radiotracers for PET imaging of relapsing prostate cancer. Minimal urinary clearance seems to be its most valuable and outstanding feature. We present images of biochemically relapsed prostate cancer where F-PSMA-1007 PET/CT (performed to verify an ambiguous finding adjacent to the urinary bladder found in F-FCH PET/CT) proved superior to radiocholine and precisely visualized site of local recurrence. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002556DOI Listing
March 2019
1 Read

Reduced Scan Time in 123I-FP-CIT SPECT Imaging Using a Large-Field Cadmium-Zinc-Telluride Camera.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Service de Physique Médicale et Radioprotection, Groupement Hospitaliers Est, Hospices Civils de Lyon, Bron.

We evaluated the reproducibility of I-ioflupane (I-FP-CIT) SPECT with shorter scan times using a CZT camera. One hundred ninety-nine I-FP-CIT SPECT scans obtained with standard scan time (30 minutes) were truncated to provide 24-, 18-, and 15-minute study simulations. Striatal binding ratios were automatically calculated and remained stable for all series. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002554DOI Listing

FDG PET in Diffuse Spinal Carcinomatous Meningitis.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Medical Oncology, Centre Eugène Marquis.

A 65-year-old man, diagnosed with right paranasal sinus neuroendocrine carcinoma with skull base invasion and ipsilateral lymph node involvement underwent chemotherapy. Six months later, the patient underwent radiation therapy for right cervical lymph node recurrence. Two months after the end of the radiation therapy, the patient was referred to our department to perform a whole-body FDG PET for therapeutic assessment. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002555DOI Listing
March 2019
2 Reads

Prostate-Specific Membrane Antigen Accumulation in Lower Extremity Lymphedema.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the THERANOSTICS Center for Molecular Radiotherapy and Precision Oncology, Bad Berka, Germany.

Prostate-specific membrane antigen (PSMA) is overexpressed in a majority of prostate cancer cells, which has led to the development of radiolabeled small-molecule inhibitors of PSMA for molecular imaging and targeted radioligand therapy. Lu-labeled PSMA, with therapeutic β-emission and concomitant γ radiation, permits posttherapy imaging for the assessment of biodistribution and uptake in tumors and normal organs, as well as dosimetry. We report a patient with prostate cancer and metastatic lymph nodes-related lower extremity lymphedema, who presented with dermal backflow and soft-tissue uptake in the lower extremity on posttherapeutic whole body scan after intravenous Lu-PSMA treatment. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002552DOI Listing
March 2019
4 Reads

Giant Cell Tumor of Tendon Sheath Revealed on 68Ga-DOTA-TATE PET/CT in a Patient With Suspicious Tumor-Induced Osteomalacia.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Giant cell tumor of tendon sheath (GCTTS) is benign mesenchymal neoplasm, and it rarely induces hypophosphatemia. We report a 49-year-old woman with suspicious tumor-induced osteomalacia underwent Ga-DOTA-TATE PET/CT to identify potential causative tumor, which showed a hypermetabolic soft tissue nodule in the right foot. Pathology confirmed it as GCTTS following surgical resection. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002550DOI Listing
March 2019
2 Reads

Pneumonitis Related to Melanoma Immunotherapy.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Department of Nuclear Medicine and.

Several regimens of immunotherapy have recently proven successful for multiple cancers, due to increased survival and quality of life. Rarely, immunotherapy with anti-programmed cell death protein 1 and programmed death-ligand 1 antibodies across cancer may cause immune-related pulmonary toxicity, with a low overall incidence, being particularly low among patients with melanoma and highest among individuals with lung cancer. In this vein, pulmonary toxicity is staged at 4 degrees according to the severity of the clinic and radiological findings, and its management is based on suppression of immunotherapy and administration of glucocorticoids. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002549DOI Listing
March 2019
3 Reads

68Ga-PSMA Uptake in Fibrous Dysplasia.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Unit of Nuclear Medicine, Aosta Regional Hospital, Aosta, Italy.

Prostate cancer is one of the most common malignancies. Imaging tools play an important role throughout the entire process of the disease. The scenario, however, is going to change. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9718
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http://dx.doi.org/10.1097/RLU.0000000000002546DOI Listing
March 2019
1 Read

Tuberculosis Presenting as Cutaneous Erythema Nodosum on 18F-FDG PET/CT.

Authors:
Tarun Kumar Jain

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Department of Nuclear Medicine and PET, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India.

The present article presented a 47-year-old woman with areas of nodular swelling and discoloration involving bilateral lower limbs since 12 months. Biopsy from skin lesions revealed erythema nodosum. As erythema nodosum can be secondary to multiple etiologies, whole-body F-FDG PET/CT was performed to assess the disease distribution and guide the site of biopsy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002547DOI Listing
March 2019
4 Reads

FDG PET/CT Findings of Unsuspected Pulmonary Epithelioid Angiosarcoma Manifested as a Brain Metastasis.

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Departments of Nuclear Medicine, and.

A 42-year-old man presented paroxysmal sharp pain in the right side of the head. Head CT showed a lesion in the right frontal lobe. MRI of the head suggested the possibility of metastasis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002544DOI Listing
March 2019
3 Reads

Peptide Receptor Radionuclide Therapy Combined With Chemotherapy in Patients With Neuroendocrine Tumors.

Clin Nucl Med 2019 May;44(5):e329-e335

From the Departments of Nuclear Medicine and.

Purpose: Combinations of therapies may enhance therapeutic effects without significantly increasing the incidence of adverse events. However, there are few data regarding survival after concomitant chemotherapy and peptide receptor radionuclide therapy (PRRT) with [Lu]Lu-octreotate in patients with neuroendocrine tumors (NETs). Thus, we explored the outcome of this combination of therapies. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002532DOI Listing

Prognostic Value of Tumor Heterogeneity and SUVmax of Pretreatment 18F-FDG PET/CT for Salivary Gland Carcinoma With High-Risk Histology.

Clin Nucl Med 2019 May;44(5):351-358

Departments of Radiation Oncology.

Purpose: Previous studies have shown that SUVmax on F-FDG PET/CT predicts prognosis in patients with salivary gland carcinoma (SGC). Here, we sought to evaluate whether texture features extracted from F-FDG PET/CT images may provide additional prognostic information for SGC with high-risk histology.

Methods: We retrospectively examined pretreatment F-FDG PET/CT images obtained from 85 patients with nonmetastatic SGC showing high-risk histology. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002530DOI Listing
May 2019
1 Read

225Ac Prostate-Specific Membrane Antigen Posttherapy α Imaging: Comparing 2 and 3 Photopeaks.

Clin Nucl Med 2019 May;44(5):401-403

Government College University, Faisalabad, Pakistan.

Ac-based PSMA-targeted therapy has emerged as promising agent for the treatment of metastatic castration-resistant prostate cancer. Posttherapy image is used for tracer localization and dosimetry. Prior 2 photopeaks of 440 and 218 KeV were reported for posttherapy imaging. Read More

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http://Insights.ovid.com/crossref?an=00003072-201905000-0001
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http://dx.doi.org/10.1097/RLU.0000000000002525DOI Listing
May 2019
1 Read

Diffuse-Type Tenosynovial Giant Cell Tumor of the Thoracic Spine: Appearance on FDG PET/CT.

Clin Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

Sichuan New Radiopharmaceuticals Technology Co, Ltd, Chengdu, People's Republic of China.

D-TGCT (diffuse-type tenosynovial giant cell tumor) is a benign proliferative disorder of the synovial membranes that usually occurs in the appendicular skeleton, especially large joints such as the knee, hip, and elbow. It rarely involves the spine. In this report, we describe a rare case of D-TGCT in the thoracic spine, which showed a lytic lesion with high FDG uptake. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002541DOI Listing
March 2019
6 Reads

Detection of Local Relapse of Prostate Cancer With 18F-PSMA-1007.

Clin Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

From the Departments of Nuclear Medicine.

Prostate-specific membrane antigen (PSMA)-targeted PET/CT has become a fundamental tool in the management of patients with prostate cancer, especially to rule out local recurrence after surgery or radiation. However, the assessment of the prostatic fossa is difficult due to the renal excretion of PSMA-targeted radionuclides. PET/CT studies using Ga-PSMA-11 PET/CT and F-PSMA-1007 of a 61-year-old man after radical prostatectomy are presented. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002543DOI Listing

Malignant Peripheral Nerve Sheath Tumor With Bilateral Adrenal Metastases: Role of 18F-FDG PET/CT in Response Assessment to Tyrosine Kinase Inhibitor and Liposomal Doxorubicin.

Clin Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Nuclear Medicine and PET-CT, Institute of Liver and Biliary Sciences, New Delhi, India.

MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis. Metastasis to bilateral adrenal glands is very rare in such group of neoplasms. We discuss a case of 85-year-old man who was diagnosed with MPNST from prevertebral mass with metastases to bilateral adrenal glands and bone marrow from the beginning and role of serial F-FDG PET/CT scans in response assessment first to sunitinib (tyrosine kinase inhibitor) and then to liposomal doxorubicin. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002542DOI Listing
March 2019
1 Read
3.931 Impact Factor

68 Ga-DOTA-TATE in Neuroblastoma With Marrow Involvement.

Authors:
Nese Torun

Clin Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

From the Department of Nuclear Medicine, Baskent University Faculty of Medicine, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana, Turkey.

A 22-month-old boy diagnosed with neuroblastoma was evaluated by bone scintigraphy and I-metaiodobenzylguanidine scintigraphy, and no metastases to skeletal system was detected. However, plain radiograph and MRI revealed suspected metastatic lesions. The patient was therefore evaluated by Ga-DOTA-TATE PET/CT, and Ga-DOTA-TATE uptake was observed in multiple bone and bone marrow areas, which were consistent with metastases. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002539DOI Listing

The Prognostic Value of Baseline 18F-FDG PET/CT in Human Papillomavirus-Positive Versus Human Papillomavirus-Negative Patients With Oropharyngeal Cancer.

Clin Nucl Med 2019 May;44(5):e323-e328

From the Department of Radiation Oncology.

Purpose: Oropharynx cancer (OPC) is heterogeneous; human papillomavirus (HPV)-positive and HPV tumors represent 2 disease entities with a different prognosis. Earlier studies investigating the prognostic value of pretreatment F-FDG PET in OPC are small or included patients with unknown HPV status. This study assessed the prognostic value of PET variables, in a large cohort with balanced HPV status. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002531DOI Listing
May 2019
2 Reads