12,369 results match your criteria Clinical Nuclear Medicine[Journal]


Hyperfunctioning Papillary Microcarcinoma Diagnosed by 124I PET/Ultrasound Fusion Imaging.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.

A 49-year-old woman presented with a multinodular goiter, causing local symptoms and hyperthyroisdism. Besides a hypofunctioning benign nodule (TIRADS 3, benign in FNAC), the conventional diagnostic revealed another small hyperfunctioning nodule with suspicious ultrasound features (TIRADS 4C). To rule out a trapping-only nodule and topographical misalignments, a I PET/ultrasound fusion was performed and confirmed elevated iodine uptake within the suspicious nodule. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002503DOI Listing
February 2019

An Isolated Osseous Rosai-Dorfman Disease Shown on FDG PET/CT.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Rosai-Dorfman disease is typically presented as lymphadenopathy, especially in the neck. Extranodal diseases also frequently occur but are generally concurrent with nodal disease. We report FDG PET/CT findings of solitary femoral Rosai-Dorfman disease without any lymphadenopathy in a pediatric patient. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002501DOI Listing
February 2019
13 Reads

18F-Choline PET/CT Imaging for Intracranial Hemangiopericytoma Recurrence.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Nuclear Medicine and.

We report the case of a 50-year-old man, with previous history of grade 3 intracranial hemangiopericytoma with initial complete surgical resection, addressed for local recurrence. Surgical revision performed 18 months after initial surgery allowed only partial resection, leaving residual disease along the optic nerve. Complementary radiotherapy with proton was decided. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002498DOI Listing
February 2019

Inflammatory Activity of Tumoral Calcinosis in a Patient With Fever of Unknown Origin.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinics of Nuclear Medicine, and.

Unexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. In absence of other pathologies, the calcinosis was deemed to be the cause of the fever. An infectious or malignant disease could be ruled out, so further therapeutic steps were enabled. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002497DOI Listing
February 2019

99mTc-LLEC Renal Dynamic Scan in a Patient With Pelvic Neuroblastoma.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Nuclear Medicine, JIPMER, Puducherry, Pondicherry, India.

A 5-month-old boy with ultrasonography showing bilateral hydronephrosis, referred for renal scan. On Tc-L,L,ethylenedicysteine (Tc-LLEC) renal scan, tracer blush in flow images in the region of urinary bladder was seen and tumor mass was suspected. Contrast-enhanced CT showed a soft tissue mass in sacrococcygeal region. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002491DOI Listing
February 2019

Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Nuclear Medicine, and.

The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002494DOI Listing
February 2019
2 Reads

Concurrent Pancreatic Metastasis From Lung Adenocarcinoma and Primary Cholangiocarcinoma on FDG PET/CT Imaging.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 67-year-old man with a history of left upper lobe resection of poorly differentiated adenocarcinoma 1 year ago underwent FDG PET/CT for restaging. The images demonstrated a round cystic lesion with peripheral FDG uptake and centrally photopenic region. Additional focus of increased activity was detected in the left lobe of the liver. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002496DOI Listing
February 2019

Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome-Associated Renal Cell Carcinoma Showing High FDG Uptake.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal-dominant disease, characterized by the development of cutaneous and uterine leiomyomas and renal cell carcinoma (RCC). Approximately 20% to 30% of patients with HLRCC syndrome develop RCC resembling sporadic type 2 papillary RCC, which is aggressive and associated with a poor prognosis. Information on the clinical usefulness of FDG PET/CT in HLRCC syndrome-associated RCC is limited. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002495DOI Listing
February 2019

Meningeal Metastasis Relapse With Focal Involvement of Cranial Bone Flap: A Case Resolved by 18F-DOPA PET/MRI.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the SyMPTOm PET/MRI Platform, Nuclear Medicine Department, and.

A 63-year-old woman was referred to our PET/MRI platform to evaluate the possible relapse of a meningeal metastasis, complicating an invasive ductal carcinoma of the left breast. This metastasis was diagnosed on a left hemiparesis and treated by surgery and radiation therapy. One year later, the same symptoms led to another brain MRI examination that found a contrast-enhanced lesion in the operating site. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002492DOI Listing
February 2019

A Case of Intramuscular Cryptococcosis Mimicking a Malignant Tumor on FDG PET/CT.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

PET/CT, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Intramuscular cryptococcosis is extremely rare. In this case, a 76-year-old man with history of acute myeloid leukemia presented a painful mass in the right upper arm. FDG PET/CT demonstrated a low-density irregular-shaped mass in the triceps muscle of the right upper arm with adjacent bone erosion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002488DOI Listing
February 2019

Multifocal Small Bowel Carcinoid: Evaluation by 68Ga-DOTATATE PET.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Radiology, Division of Nuclear Medicine, Mayo Clinic, Rochester, MN.

Carcinoid is a subtype of neuroendocrine tumor, a rare group of tumors that are known to express somatostatin receptor 2. Ga-DOTATATE is a somatostatin analog that is specific for somatostatin receptor 2 and therefore allows visualization of neuroendocrine tumors. We present 2 cases of primary multifocal small bowel carcinoid evaluated using Ga-DOTATATE PET/CT, along with contrast-enhanced CT corollary findings. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002487DOI Listing
February 2019

A Case of Radioactive Iodine Uptake Found in Artificial Eye.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, South Korea.

Radioactive iodine (RAI) therapy is widely used as an adjunctive treatment in patients with differentiated thyroid cancer. Although I has high avidity in the functioning thyroid, and in differentiated thyroid cancer lesions, physiological and nonspecific uptake of I in healthy or benign tissue may contribute to false-positive findings on an I scan. Here, we present an interesting image of RAI uptake in the eye region post-RAI treatment, which has been identified as tear contamination in the artificial eye. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002486DOI Listing
February 2019
1 Read

Pachymeningitis Demonstrated on Gallium SPECT/CT Scan.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

A 34-year-old woman presented with a 3-month history of right-sided headaches associated with photophobia and pulsatile tinnitus. Investigations including lumbar puncture revealed elevated opening CSF pressure, increased protein, and presence of monocytosis consistent with an inflammatory/infective process. Brain MRI showed an area of thickened enhancing dura around the venous sinus posteriorly. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002484DOI Listing
February 2019
3.931 Impact Factor

18F-FDG PET/CT Demonstrates Renal Cell Cancer in a Transplant With Synchronous Intestinal Infection.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Nuclear Medicine and PET/CT, and.

We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002482DOI Listing
February 2019

Similar Appearance on Dynamic Images of Meckel Scintigraphy Caused by Different Etiologies: The Value of Lateral Views.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Positive gastric mucosa Meckel diverticulum generally shows nonmoving activity in the right abdomen, which appears early in the study at about the same time of the appearance of the stomach. However, a stoma from ileostomy can result in similar findings on dynamic images. The difference between a true Meckel diverticulum and stoma can be exposed by lateral views. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002479DOI Listing
January 2019

Superscan 18F-Fluciclovine PET/CT of PSA-Negative Prostate Cancer Bone Metastases.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

A 76-year-old man presented with recently diagnosed prostate adenocarcinoma, Gleason score of 4 + 4, and a Super bone scan with concurrent PSA of 1.7 ng/mL. Approximately 3. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002478DOI Listing
January 2019

Remarkable Response of Pulmonary Metastases Rather Than Remnant Thyroid in 131I Therapy of Follicular Thyroid Cancer.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Departments of Nuclear Medicine.

A 66-year-old man with follicular thyroid cancer after total thyroidectomy was referred for I therapy. Thyroid function tests before I administration exhibited severe thyrotoxicosis although the patient did not take levothyroxine after thyroidectomy. A 185 MBq I whole-body scintigraphy and SPECT/CT revealed multiple iodine-avid pulmonary metastases with the largest tumor diameter of 1. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002477DOI Listing
January 2019

Lymphadenopathy Due to Kimura's Disease Mimicking Lymphoma on FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao, China.

Kimura's disease is a clinically rare, chronic, benign lymphoproliferative disorder of unknown etiology. A 36-year-old man presented with painless axillary swelling, which was suspected as lymphoma. PET/CT was performed for staging. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002474DOI Listing
January 2019
1 Read

68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Urology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002473DOI Listing
January 2019
6 Reads

68Ga-PSMA Uptake in Prostate Cancer Sciatic Nerve Metastasis.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Nuclear Medicine Department, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Most prostate cancers spread to regional lymph nodes, axial skeleton and lungs. Perineural malignant involvement is very rare. We present a Ga-PSMA PET/CT image of a sciatic nerve metastasis in a 65-year-old man with recurrent prostate cancer. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002476DOI Listing
January 2019
3 Reads

Dynamic Renal Ptosis Demonstrated on 18F-FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Nuclear Medicine Service, Department of Radiology, Walter Reed National Military Medical Center, Bethesda, MD.

Renal ptosis, otherwise known as nephroptosis or "floating kidney," is a condition of abnormal descent of the kidney, often asymptomatic with controversy over its clinical and therapeutic significance. The aberrant location of renal and renal collecting system activity associated with this condition may serve as a diagnostic pitfall in PET/CT interpretation. We report a case of dynamic renal ptosis demonstrated on F-FDG PET/CT, identified as right kidney migration from an ectopic location on attenuation correction CT images, obtained immediately after upright positioning, to the right renal fossa on subsequent PET images, obtained after approximately 10 min of supine positioning. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002475DOI Listing
January 2019
3 Reads

Pericholecystic Rim Sign and Gallbladder Nonvisualization Indicating Acute Gangrenous Cholecystitis on 99mTc-MIBI Myocardial Perfusion SPECT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Nuclear Medicine, Taleghani Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Rim sign is assumed as an ominous sign of gangrenous cholecystitis and mandates an urgent surgery. The main mechanism by which this phenomenon arises is increased regional blood flow as a result of an inflammatory process. Therefore, it is expected that this finding be visualized in varieties of scans with various radiopharmaceuticals, including myocardial perfusion scan with Tc-MIBI as an extracardiac finding. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002472DOI Listing
January 2019

Quality and Safety in Health Care, Part LI: Engagement and Burnout.

Authors:
Jay A Harolds

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Advanced Radiology Services and the Division of Radiology and Biomedical Imaging, College of Human Services, Michigan State University, Grand Rapids, MI.

Engagement has 3 different components, the most important of which are felt by some to be vigor and dedication. The third component is absorption. Engagement is considered by some to be the opposite of burnout, although others consider these terms to be not quite opposite, but nearly so. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002471DOI Listing
January 2019

Acral Involvement of Lymphoblastic Lymphoma Revealed on FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Lymphoma rarely involves hand or foot. We presented the FDG PET/CT findings of lymphoblastic lymphoma in a 28-year-old man who had recurrent disease in many bones, including those of the hand and foot without any lymph node involvement 17 years after initial diagnosis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002470DOI Listing
January 2019

Resolution of Hypoxic Tissue in Cerebellar Hemispheres After Arterial Bypass Surgery in a Patient With Symptomatic Bilateral Vertebral Artery Occlusion: A 18F-FRP170 PET Study.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Neurosurgery and Cyclotron Research Center, Iwate Medical University, Morioka, Japan.

A 48-year-old man experienced recurrent vertigo refractory to antiplatelet medications. Cerebral angiography showed occlusion of bilateral vertebral arteries with poor collateral circulation. PET using O2 gas showed reduced blood flow and metabolic rate of oxygen and elevated oxygen extraction fraction in bilateral cerebellar hemispheres. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002469DOI Listing
January 2019
3 Reads

Primary Pulmonary Paraganglioma Revealed by FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.

Primary pulmonary paraganglioma is a rare type of extra-adrenal paragangliomas arising from neuroectodermal-derived paraganglionic tissue. We report herein the case of a 49-year-old woman with a round-like well-defined nodule in the right middle lobe detected by chest CT. FDG PET/CT also revealed this homogeneous nodule with increased FDG accumulation. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002468DOI Listing
January 2019

Hepatocellular Carcinoma Mimicking Neuroendocrine Tumor Metastasis on 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Radiology, Memorial Sloan Kettering Cancer Center; and Department of Radiology, Weill Cornell Medical College, New York, NY.

Ga-DOTATATE is a radiolabeled somatostatin analog used for the detection and characterization of somatostatin receptor (SSR)-overexpressing tumors, particularly well-differentiated neuroendocrine tumors. We present a case of a 65-year-old man with well-differentiated pancreatic neuroendocrine tumor post-Whipple surgery and a new liver lesion on CT. Ga-DOTATATE PET/CT was performed for SSR characterization and restaging, which demonstrated the lesion to be intensely SSR positive and interpreted as a neuroendocrine metastasis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002467DOI Listing
January 2019
4 Reads

18F-FDG PET/CT in Intramuscular Mantle Cell Lymphoma With Elongated Lymphomatous Neurovascular Extension.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Institute of Nuclear Medicine and Molecular Imaging, Soroka University Medical Center, Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel.

Skeletal muscle involvement by lymphoma is rare, particularly for mantle cell lymphoma. We describe a 65-year-old man who presented with a rapidly growing left thigh mass. FDG PET/CT characterized the mass as malignant. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002466DOI Listing
January 2019
1 Read

Tumor Identification of Less Aggressive or Indolent Lymphoma With Whole-Body 11C-Acetate PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Departments of Diagnostic Radiology and Nuclear Medicine, and.

Purpose: The aim of this study was to investigate the diagnostic performance of whole-body [C]acetate PET/CT in less aggressive or indolent lymphomas, wherein [F]FDG PET/CT would exhibit limited sensitivity.

Methods: Between September 2016 and May 2018, we prospectively evaluated 17 patients (9 men, 8 women; mean age [range], 71 [45-87] years) with pathologically proven less aggressive or indolent lymphomas according to Non-Hodgkin's Lymphoma Classification Project, using both [F]FDG PET/CT and [C]acetate PET/CT (performed on the same day). Detected nodal lesions were recorded according to the Ann Arbor classification. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002464DOI Listing
January 2019

Effect of Sentinel Node Biopsy in Clinically N0, BRAF V600E-Mutated, Small Papillary Thyroid Carcinoma: A Pilot Study.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

General Surgery Unit, Azienda Ospedaliera Universitaria Pisana.

Purpose: BRAF V600E mutation papillary thyroid cancer (PTC) is more aggressive with a higher risk of lymph node involvement and a poorer prognosis. Prior studies failed to demonstrate the superiority of prophylactic lymphadenectomy. We investigated the utility of additional radio-guided sentinel node biopsy (SNB). Read More

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http://dx.doi.org/10.1097/RLU.0000000000002465DOI Listing
January 2019
1 Read

Baseline Pancreatic Beta Cell Imaging After Pancreatic Transplantation Using Whole-Body 68Ga-DOTA-Exendin-4 PET/CT: A Spectrum of 2 Cases of Diabetes Mellitus.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

From the Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, Tamil Nadu, India.

Whole pancreatic transplant and islet cells transplantation are currently available strategies aiming toward diabetes cure. Beta cell specific noninvasive functional imaging using novel PET radiotracers are now available and can be used for beta cell imaging and quantification. Herein we describe a spectrum of 2 cases demonstrating beta cell targeted imaging using Ga-DOTA-exendin-4 PET/CT in patients with diabetes after simultaneous pancreas-kidney transplantation. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002461DOI Listing
January 2019

Multiple Myeloma of Testes and Spermatic Cord on 18F-FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Health Science North, Subbury, Ontario, Canada.

Extramedullary multiple myeloma (EM) has negative prognostic implications on the overall survival as well as progression-free survival. Testis is a rare site of EM, which can be a part of diffuse involvement in multiple myeloma or a site of recurrence in patients with remission. We present a case of EM of testes and left spermatic cord in an 80-year-old man who presented with painless progressive enlargement of the scrotum. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002462DOI Listing
January 2019
2 Reads

Diagnosis of Primary Clear Cell Carcinoma of the Vagina by 18F-FDG PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

A 41-year-old woman presented with irregular vaginal bleeding, and a vaginal tumor was found and proved to be a clear cell carcinoma by biopsy. An F-FDG PET/CT was performed to exclude its metastatic possibility, which showed the vaginal tumor was the only lesion with F-FDG avidity. The vaginectomy and hysterectomy were performed to resect the lesion, and primary clear cell carcinoma of the vagina was finally diagnosed. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002463DOI Listing
January 2019
3.931 Impact Factor

Pattern of FDG and MET Distribution in High- and Low-Grade Gliomas on PET Images.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose Of The Report: This study aimed to determine the most effective metabolic index of FDG-PET and MET-PET to differentiate high- and low-grade gliomas, and then to characterize tumor metabolism according to the 2016 WHO classification. We also developed a new calculation method of potential infiltrative tumor volume to overcome the current limitations of tumor evaluation according to metabolic index, which focuses solely on tumor core area.

Materials And Methods: Patients who underwent both FDG-PET and MET-PET, as well as surgical treatment, were retrospectively identified. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002460DOI Listing
January 2019

Predicting Response to Immunotherapy by Evaluating Tumors, Lymphoid Cell-Rich Organs, and Immune-Related Adverse Events Using FDG-PET/CT.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

Division of Nuclear Medicine, Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR.

Purpose: To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy.

Methods: Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from December 2013 to December 2016 were retrospectively enrolled (malignant melanoma, n = 21; malignant lymphoma, n = 11; renal cell carcinoma, n = 8). SUVmax of the baseline and first restaging scans were evaluated in tumors, spleen, bone marrow, thyroid and pituitary glands, and were correlated to best overall response in the first year after therapy; IRAE-affected areas were also evaluated. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002453DOI Listing
January 2019
2 Reads

Anaplastic Oligodendroglioma Found as an Incidental Photopenic Lesion on 18F-FP-CIT PET/CT Image.

Clin Nucl Med 2019 Mar;44(3):e168-e169

From the Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, South Korea.

F-FP-CIT PET is a useful modality for imaging dopamine transporters. It has excellent resolution compared with I-beta-CIT SPECT and is widely used clinically for the evaluation of Parkinson disease. In general, the main focus of F-FP-CIT PET imaging is the basal ganglia, and it is important to observe whether F-FP-CIT uptake is normal in the putamen and caudate nuclei. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002459DOI Listing
March 2019
3.931 Impact Factor

99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia.

Clin Nucl Med 2019 Mar;44(3):209-213

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.

Purpose: Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002458DOI Listing
March 2019
1 Read

Delayed Response (Partial Remission) 3 Years After Peptide Receptor Radionuclide Therapy in a Patient Participating in the NETTER-1 Trial.

Clin Nucl Med 2019 Mar;44(3):223-226

From the Theranostics Center for Molecular Radiotherapy and Precision Oncology, Zentralklinik Bad Berka, Bad Berka, Germany.

Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogues has been shown to be highly efficacious concerning progression-free survival and response rates in patients with advanced, progressive, well-differentiated, somatostatin-receptor-positive neuroendocrine neoplasm. We report here delayed response of a midgut neuroendocrine neoplasm patient, who had stable disease after 4 cycles of PRRT and over a long period of 5 restaging admissions with excellent quality of life (full working hours), persisting for 3 years of follow-up, and presented as further partial remission according to both Response Evaluation Criteria in Solid Tumors and EORTC criteria, respectively, 36 months after the last PRRT cycle. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002456DOI Listing
March 2019
5 Reads

Spontaneous Regression of Clinically Indolent Lymphomas Revealed by 18F-FDG PET/CT.

Clin Nucl Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.

A 48-year-old man and a 55-year-old woman, who were diagnosed with follicular lymphoma and small B lymphocytic cell lymphoma, respectively, underwent initial "watch-and-wait" approach against lymphoma. The initial F-FDG PET/CT of both patients showed multiple FDG-avid lymph nodes in the neck, mediastinum, abdomen, and inguinal regions. During their active surveillance, the follow-up PET/CT of both patients revealed spontaneous regression of lymphoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002457DOI Listing
January 2019
3 Reads

Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT.

Clin Nucl Med 2019 Jan 18. Epub 2019 Jan 18.

From the PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

A 47-year-old woman suffered worsening pain in the waist and numbness in the right thigh for 1 month. MRI was performed to determine the cause, which detected an osteolytic lesion in the T12 vertebral body, suggestive of possible bone metastasis. FDG PET/CT scan was undertaken to detect the primary tumor, which only showed the same isolated lesion in the T12 without any other abnormal hypermetabolic lesion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002450DOI Listing
January 2019
4 Reads

Focal 123I-MIBG Uptake in the Medial Segment of the Normal Liver.

Clin Nucl Med 2019 Mar;44(3):e170-e171

From the Department of Radiology, Keio University School of Medicine, Tokyo, Japan.

An 84-year-old man with parkinsonism was referred for I-MIBG scintigraphy. Abnormal uptake in the right upper abdomen was incidentally seen in planar image, and SPECT revealed focal uptake in the medial segment (S4) of the liver. Subsequent triple-phase contrast-enhanced CT showed no evidence of hepatic tumors, although in the arterial phase, there were an enhanced region corresponding to the uptake area and the enhanced vein of Sappey that flowed into S4. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002449DOI Listing

Parapharyngeal Ganglioneuroma Detected by 18F-FDG PET/CT in a Patient With Hodgkin Lymphoma.

Clin Nucl Med 2019 Mar;44(3):240-243

Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan.

A 38-year-old woman with anterior mediastinal Hodgkin lymphoma underwent F-FDG PET/CT, revealing abnormal uptake at the left retrostyloid parapharyngeal space. After chemotherapy, follow-up PET/CT showed regression of previously avid lesions but not the left retropharyngeal mass. Subsequent MRI revealed findings suggestive of neurogenic tumor. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002444DOI Listing
March 2019
3 Reads

18F-FDG-Labeled Autologous Leukocyte PET-CT in a Patient With Aortic Valve-Tube Graft Infection After Bentall Procedure.

Clin Nucl Med 2019 Mar;44(3):e161-e162

From the Departments of Nuclear Medicine and.

Infection of aortic valve-tube graft, although rare, is associated with high morbidity and mortality. Early identification of site and extent of infection is not only challenging but also crucial for adequate patient management and prognostication of disease. Combined clinical, laboratory investigation and imaging modalities assist in the identification of aortic valve graft infection. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002447DOI Listing

The New Possibility of Lymphoscintigraphy to Guide a Clinical Treatment for Lymphedema in Patient With Breast Cancer.

Clin Nucl Med 2019 Mar;44(3):179-185

From the Departments of Rehabilitation Medicine and.

Objectives: Lymphedema is a chronic disease that occurs frequently after breast cancer treatment. For the treatment of lymphedema, surgical approach such as vascularized lymph node transfer and super-microscopic lymphovenous anastomosis surgery is well established. Complex decongestive therapy (CDT) and sympathetic ganglion block (SGB) are two non-surgical therapeutic options. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002443DOI Listing
March 2019
1 Read

Myocardial Infarction With Nonobstructive Coronary Arteries Assessed by 11C-Acetate Cardiac PET.

Clin Nucl Med 2019 Mar;44(3):e166-e167

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.

C-acetate PET can quantify myocardial blood flow and oxidative metabolism (kmono) with a single imaging study. We present a 63-year-old man with myocardial infarction with nonobstructive coronary arteries due to vasospasm, who underwent C-acetate PET after antispastic medication. By quantifying myocardial blood flow and kmono, C-acetate PET could detect the initial ischemic insult by vasospasm and sufficient amount of remaining viable myocardium, while excluding significant inducible ischemia. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002431DOI Listing
March 2019
1 Read

68Ga-DOTANOC PET/CT Detects Multifocal Hepatocellular Carcinoma.

Clin Nucl Med 2019 Mar;44(3):238-239

From the Nuclear Medicine, Department of Experimental, Diagnostic and Specialty Medicine, and.

Ga-DOTANOC PET/CT confirmed somatostatin receptor (SR) expression in hypervascularized liver lesions suggestive of neuroendocrine tumor that was later diagnosed as hepatocellular carcinoma (HCC). Being highly vascularized on CT, HCC lesions may mimic neuroendocrine tumors. Although HCC is not included among current indications for SR-PET/CT imaging, it may represent a pitfall in image interpretation when studying neuroendocrine tumor patients. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002426DOI Listing

68Ga-DOTATATE in Benign Prostate Hyperplasia.

Authors:
Jiaqiong Wang

Clin Nucl Med 2019 Mar;44(3):249-250

From the Division of Nuclear Medicine, Department of Radiology, Miller School of Medicine, University of Miami Hospital/Jackson Memorial Hospital, Miami, FL.

A 79-year-old man had carcinoid syndrome and bilateral pulmonary nodules, which were biopsy confirmed as well-differentiated neuroendocrine tumor. PET/CT with Ga-[DOTA-Tyr]-octreotate (Ga-DOTATATE) showed multiple Ga-DOTATATE-avid bilateral pulmonary nodules, left hilar lymph node, as well as diffuse increased Ga-DOTATATE uptake in the prostate. A review of the history revealed that this patient had elevated prostate-specific antigen level. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002454DOI Listing
March 2019
3 Reads

Diffuse Bone Metastases in Pancreatic Neuroendocrine Tumor Shown on Octreoscan.

Authors:
Jake Adkins Yang Lu

Clin Nucl Med 2019 Mar;44(3):257-258

From the Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center Houston, TX.

A 32-year-old man with a pancreatic neuroendocrine tumor and known liver metastasis presented with diffuse back pain. Workup octreoscan showed newly developed diffuse bone metastases, in addition to the persistent liver metastases. The bone metastases were later confirmed on MRI spine images. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002455DOI Listing
March 2019
1 Read

Heterogeneous Uptake of 18F-FDG and 68Ga-PSMA-11 in Hepatocellular Carcinoma.

Clin Nucl Med 2019 Mar;44(3):e133-e135

From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA.

We present the case of an 87-year-old man with a history of melanoma metastatic to the lungs found to have an FDG-negative liver lesion that was initially thought to be benign. Follow-up CT revealed growth of the liver lesion despite excellent response to nivolumab therapy of the pulmonary melanoma metastases. Biopsy of the lesion confirmed primary hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002452DOI Listing
March 2019
6 Reads

Diffuse-Type Tenosynovial Giant Cell Tumor of the Shoulder Evaluated by FDG PET/CT.

Clin Nucl Med 2019 Jan 4. Epub 2019 Jan 4.

Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Diffuse-type tenosynovial giant cell tumor is a locally aggressive neoplasm that typically involves the knee and hip but rarely involves the shoulder. In this case, a 74-year-old woman presented a painless mass in the right shoulder. FDG PET/CT demonstrated intense FDG uptake with an SUVmax of 19. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002451DOI Listing
January 2019
9 Reads