7,621 results match your criteria Clinical Neurophysiology[Journal]


A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

Clin Neurophysiol 2019 Apr 11;130(6):1017-1024. Epub 2019 Apr 11.

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, IS, Italy.

Objective: we investigated the effect of anodal transcranial direct current stimulation (tDCS) applied over the pharyngeal motor area in dysphagia associated with multiple sclerosis (MS).

Methods: Eighteen MS patients with dysphagia associated with brainstem involvement were randomized to receive either "real" or "sham" tDCS.

Primary Outcome: The Penetration/Aspiration Scale (PAS). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.04.003DOI Listing

Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity: A comparative study via EEG graph theory.

Clin Neurophysiol 2019 Apr 6;130(6):997-1007. Epub 2019 Apr 6.

Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Neurology, Area of Neuroscience, Catholic University of The Sacred Heart, Rome, Italy.

Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms.

Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193011
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http://dx.doi.org/10.1016/j.clinph.2019.03.017DOI Listing
April 2019
2 Reads

Endpoint accuracy of goal-directed ankle movements correlates to over-ground walking in stroke.

Clin Neurophysiol 2019 Apr 13;130(6):1008-1016. Epub 2019 Apr 13.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.

Objectives: Goal-directed movements are essential for voluntary motor control. The inability to execute precise goal-directed movements after stroke can impair the ability to perform voluntary functions, learn new skills, and hinder rehabilitation. However, little is known about how the accuracy of single-joint, goal-directed ankle movements relates to multi-joint, lower limb function in stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193012
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http://dx.doi.org/10.1016/j.clinph.2019.03.030DOI Listing
April 2019
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Event-related potentials as possible indicators of behavioral intervention outcome in tic disorders.

Clin Neurophysiol 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.clinph.2019.04.001DOI Listing
April 2019
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EEG correlates of face recognition in patients with schizophrenia spectrum disorders: A systematic review.

Clin Neurophysiol 2019 Apr 10;130(6):986-996. Epub 2019 Apr 10.

Moscow Research Institute of Psychiatry - the Branch of V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russian Federation.

Objective: To systematically assess EEG studies and evaluate neuropsychological changes of face recognition in the context of neutral face stimuli in individuals with schizophrenia spectrum disorders.

Methods: A literature search was conducted using the PubMed database from inception to March 2018. Studies included in the review measured any event-related potentials, neural oscillations, or phase synchrony. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.027DOI Listing

Redaction of false high frequency oscillations due to muscle artifact improves specificity to epileptic tissue.

Clin Neurophysiol 2019 Apr 11;130(6):976-985. Epub 2019 Apr 11.

Department of Neurology, University of Michigan, USA; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, USA. Electronic address:

Objective: High Frequency Oscillations (HFOs) are a promising biomarker of epilepsy. HFOs are typically acquired on intracranial electrodes, but contamination from muscle artifacts is still problematic in HFO analysis. This paper evaluates the effect of myogenic artifacts on intracranial HFO detection and how to remove them. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.028DOI Listing
April 2019
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Altered predictive contextual processing of emotional faces versus abstract stimuli in adults with Autism Spectrum Disorder.

Clin Neurophysiol 2019 Apr 13;130(6):963-975. Epub 2019 Apr 13.

Department of Psychology, University of A Coruña, Spain.

Objectives: We investigated the proposition that Autism Spectrum Disorder (ASD) is associated with predictive contextual processing deficits.

Methods: We recorded electroencephalography (EEG) in adults with ASD and controls during the performance of a predictive contextual processing task, using either triangles or emotional faces. Targets were preceded by either randomized sequences (R) or by sequences including a predictive sequence (P). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.031DOI Listing
April 2019
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Need to find a signature of abnormal brain oscillations in task-specific focal dystonia.

Clin Neurophysiol 2019 Apr 9. Epub 2019 Apr 9.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegard Allé 30, 2650 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.clinph.2019.04.002DOI Listing
April 2019
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Do not rely on imaging to predict awakening: The value of neurophysiology in a case of Weston-Hurst syndrome.

Clin Neurophysiol 2019 Apr 5;130(6):960-962. Epub 2019 Apr 5.

Service de réanimation neurologique, hospices civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.03.014DOI Listing

Postoperative navigated transcranial magnetic stimulation to predict motor recovery after surgery of tumors in motor eloquent areas.

Clin Neurophysiol 2019 Apr 5;130(6):952-959. Epub 2019 Apr 5.

Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Objective: To know whether motor deficits after tumor surgery are transient is reassuring for the patient and crucial for planning rehabilitation and adjuvant treatment. We analyze the value of postoperative MRI navigated transcranial magnetic stimulation (nTMS) compared to intraoperative MEP monitoring in predicting recovery of motor function.

Methods: Retrospective series of nTMS mappings within 14 days after surgery for supratentorial tumors (09/2014-05/2018). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.015DOI Listing

Dorsal root ganglion stimulation for chronic pain modulates Aβ-fiber activity but not C-fiber activity: A computational modeling study.

Clin Neurophysiol 2019 Mar 15;130(6):941-951. Epub 2019 Mar 15.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objective: The goal of this project was to use computational models to investigate which types of primary sensory neurons are modulated by dorsal root ganglion stimulation (DRGS) to provide pain relief.

Methods: We modeled DRGS by coupling an anatomical finite element model of a human L5 dorsal root ganglion to biophysical models of primary sensory neurons. We calculated the stimulation amplitude needed to elicit an action potential in each neuron, and examined how DRGS affected sensory neuron activity. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.016DOI Listing

Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA.

Clin Neurophysiol 2019 Mar 28;130(6):925-940. Epub 2019 Mar 28.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

The pedunculopontine nucleus (PPN) is located in the mesopontine tegmentum and is best delimited by a group of large cholinergic neurons adjacent to the decussation of the superior cerebellar peduncle. This part of the brain, populated by many other neuronal groups, is a crossroads for many important functions. Good evidence relates the PPN to control of reflex reactions, sleep-wake cycles, posture and gait. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.008DOI Listing

Mitigating the risk of triggering intraoperative seizures with cortical stimulation.

Clin Neurophysiol 2019 Apr 5. Epub 2019 Apr 5.

Section of Neurophysiology, Department of Neurosciences, King Faisal Specialist Hospital & Research Center, MBC 76, PO Box 3354, Riyadh 11211, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.03.013DOI Listing
April 2019
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Direct comparison of oscillatory activity in the motor system of Parkinson's disease and dystonia: A review of the literature and meta-analysis.

Clin Neurophysiol 2019 Mar 15;130(6):917-924. Epub 2019 Mar 15.

Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Neurology, Amsterdam UMC, University of Amsterdam, Netherlands. Electronic address:

Objective: To outline the current knowledge of (sub)cortical oscillations in Parkinson's Disease (PD) and dystonia, and to quantitatively summarize the results of direct comparisons of local oscillatory power between both diseases in the resting state, without medication or stimulation, in both the low-frequency (LF, ±4-12 Hz) and beta (±13 to ∼30 Hz) range.

Methods: Eight relevant studies were included. Recordings from 127 dystonia-, and 144 PD-patient hemispheres were analyzed. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.015DOI Listing
March 2019
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GABA-ergic tone hypothesis in hepatic encephalopathy - Revisited.

Clin Neurophysiol 2019 Mar 30;130(6):911-916. Epub 2019 Mar 30.

Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

Objective: The GABA hypothesis of hepatic encephalopathy (HE) proposes an increased cerebral GABA-ergic tone in HE but has not been investigated in vivo in HE-patients yet. Cortical GABA-ergic and glutamatergic neurotransmission in HE-patients were evaluated using transcranial magnetic stimulation.

Methods: Twenty-one patients with HE grade 1 and 2 and age matched controls participated in the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193010
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http://dx.doi.org/10.1016/j.clinph.2019.03.011DOI Listing
March 2019
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Length-dependent truncal Aδ-fiber dysfunction in hereditary transthyretin amyloidosis: An intra-epidermal electrical stimulation study.

Clin Neurophysiol 2019 Mar 23;130(6):903-910. Epub 2019 Mar 23.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan; Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.

Objective: To elucidate Aδ-fiber dysfunction at the trunk in patients with hereditary transthyretin (ATTRm) amyloidosis using intra-epidermal electrical stimulation (IES).

Methods: In 16 patients with ATTRm amyloidosis and 18 healthy subjects, sensory thresholds using IES and cooling detection thresholds using the Computer-Aided Sensory Evaluation (CASE IV) system, were assessed to investigate Aδ-fiber functions at the Th10 level of the anterior, lateral, and posterior trunk. Furthermore, evoked potentials (EPs) following electrical stimulation using IES at the anterior and posterior trunk were evaluated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.007DOI Listing

Sleep spindle characteristics in adolescents.

Clin Neurophysiol 2019 Mar 18;130(6):893-902. Epub 2019 Mar 18.

Center for Health Sciences, SRI International, Menlo Park, CA, USA; Brain Function Research Group, School of Physiology, University of Witwatersrand, Johannesburg, South Africa.

Objective: Sleep changes substantially during adolescence; however, our understanding of age-related differences in specific electroencephalographic waveforms during this developmental period is limited.

Method: Sigma power, spindle characteristics and cognitive data were calculated for fast (∼13 Hz) central and slow (∼11 Hz) frontal sleep spindles for a large cross-sectional sample of adolescents (N = 134, aged 12-21 years, from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) study).

Results: Older age (and advanced pubertal development) was associated with lower absolute sigma power and greater fast spindle density, with spindles having a shorter duration and smaller amplitude and occurring at a faster average frequency than at a younger age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193008
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http://dx.doi.org/10.1016/j.clinph.2019.02.019DOI Listing
March 2019
3 Reads

Cerebellar inhibition in hepatic encephalopathy.

Clin Neurophysiol 2019 Mar 30;130(6):886-892. Epub 2019 Mar 30.

Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany. Electronic address:

Objective: Previous animal work reported that hyperammonemia leads to opposing changes of GABAergic neurotransmission in terms of increase in the cerebellum and decrease in the cerebral cortex. In this study, we investigate GABAergic tone in the cerebellum in patients with hepatic encephalopathy (HE) at different stages of the disease and its relation to critical flicker frequency (CFF) and ataxia.

Methods: Cerebellar inhibition using transcranial magnetic stimulation was investigated in 15 patients with different stages of HE and 15 healthy controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.020DOI Listing
March 2019
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Postictal EEG changes following focal seizures: Interrater agreement and comparison to frequency analysis.

Clin Neurophysiol 2019 Mar 22;130(6):879-885. Epub 2019 Mar 22.

Department of Neurophysiology, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; Department of Neuroscience, University of Copenhagen, Denmark.

Objectives: To compare frequency analysis to human raters and determine the interrater agreement of postictal EEG changes after focal seizures.

Methods: 24 focal seizures with and without impaired awareness recorded with scalp-EEG in the epilepsy monitoring unit were selected. Five board-certified neurophysiologists annotated seizure termination and end of postictal changes for all seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193008
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http://dx.doi.org/10.1016/j.clinph.2019.03.001DOI Listing
March 2019
2 Reads

Disease-specific patterns of basal ganglia neuronal activity in Neurodegeneration with Brain Iron Accumulation type I (NBIA-1).

Clin Neurophysiol 2019 Mar 26;130(6):877-878. Epub 2019 Mar 26.

Complex Motor Disorders Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.clinph.2019.03.005DOI Listing

Clinical neurophysiology: The quest to understand motor and postural control.

Neurophysiol Clin 2019 Apr;49(2):89-90

Service de physiologie - explorations fonctionnelles, neurophysiologie clinique, hôpital Henri Mondor, Assistance publique-Hôpitaux de Paris, 94000 Créteil, France; EA 4391, faculté de médecine de Créteil, université Paris Est Créteil, 94000 Créteil, France. Electronic address:

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http://dx.doi.org/10.1016/j.neucli.2019.03.003DOI Listing
April 2019
3 Reads

"Spastic dystonia" or "Inability to voluntary silence EMG activity"? Time for clarifying the nomenclature.

Clin Neurophysiol 2019 Mar 27. Epub 2019 Mar 27.

Academic Neurology Unit, A. Fiorini Hospital, Terracina, LT, Italy; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Italy.

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http://dx.doi.org/10.1016/j.clinph.2019.03.009DOI Listing
March 2019
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"Spastic Dystonia", "Dystonia with Spasticity" or "Dystonia accompanying the Upper Motor Neuron Complex"? A reconciliation of nomenclature is needed.

Clin Neurophysiol 2019 Mar 27. Epub 2019 Mar 27.

Complex Motor Disorders Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, UK; Department of Women and Children's Health, King's College London, UK.

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http://dx.doi.org/10.1016/j.clinph.2019.03.010DOI Listing
March 2019
2 Reads
3.097 Impact Factor

Factors that modify the risk of intraoperative seizures triggered by electrical stimulation during supratentorial functional mapping.

Clin Neurophysiol 2019 Mar 23. Epub 2019 Mar 23.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Objective: Intraoperative mapping via electrical stimulation is the gold standard technique for surgeries close to the eloquent cortex. However, it can trigger seizures which immediately impact patient's safety. We studied whether administration of antiepileptic drugs (AED) prior to and/or at the beginning of the surgery decreases the probability of triggering seizures, while adjusting for other risk factors. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.006DOI Listing
March 2019
2 Reads
3.097 Impact Factor

Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia.

Clin Neurophysiol 2019 Mar 23. Epub 2019 Mar 23.

Human Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, United States.

Objective: Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production.

Method: Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.003DOI Listing
March 2019
2 Reads

Potential impact of bifrontal transcranial random noise stimulation (tRNS) on the semantic Stroop effect and its resting-state EEG correlates.

Neurophysiol Clin 2019 Mar 28. Epub 2019 Mar 28.

Inserm, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, 69000 Lyon, France; University Lyon 1, 69000 Villeurbanne, France; Centre hospitalier Le Vinatier, bâtiment 416, 95, boulevard Pinel, BP 300 39, 69678 Bron cedex, France.

Objective: The Stroop effect performance reflects cognitive resistance to interference. We aimed to investigate the effect of a single transcranial random noise stimulation session (tRNS) applied over the dorsolateral prefrontal cortex (DLPFC) on the semantic Stroop effect and its resting electroencephalography (EEG) correlates (β/α ratio).

Methods: In a randomized, double-blind study, healthy volunteers were allocated to receive either one session of active tRNS (n=8) or one session of sham tRNS (n=11). Read More

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http://dx.doi.org/10.1016/j.neucli.2019.03.002DOI Listing

Rising solutions for secondary treatment failure in patients on chronic botulinum neurotoxin therapy.

Authors:
G Leodori A Suppa

Clin Neurophysiol 2019 Mar 22. Epub 2019 Mar 22.

IRCCS Neuromed Institute, Pozzilli IS, Italy; Department of Human Neurosciences, Sapienza University of Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.03.002DOI Listing

The unsolved role of heightened connectivity from the unaffected hemisphere to paretic arm muscles in chronic stroke.

Clin Neurophysiol 2019 May 18;130(5):781-788. Epub 2019 Mar 18.

Institute of Neurology, University College London, WC1N 3BG, UK.

Objective: Ipsilateral connectivity from the non-stroke hemisphere to paretic arm muscles appears to play little role in functional recovery, which instead depends on contralateral connectivity from the stroke hemisphere. Yet the incidence of ipsilateral projections in stroke survivors is often reported to be higher than normal. We tested this directly using a sensitive measure of connectivity to proximal arm muscles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193008
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http://dx.doi.org/10.1016/j.clinph.2019.02.018DOI Listing
May 2019
4 Reads

Corrigendum to 'Emotion identification and aging: Behavioral and neural age-related changes' [Clin. Neurophysiol. 129 (2018) 1020-1029].

Clin Neurophysiol 2019 Mar 25. Epub 2019 Mar 25.

Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal.

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http://dx.doi.org/10.1016/j.clinph.2019.03.004DOI Listing

Does hand robotic rehabilitation improve motor function by rebalancing interhemispheric connectivity after chronic stroke? Encouraging data from a randomised-clinical-trial.

Clin Neurophysiol 2019 May 15;130(5):767-780. Epub 2019 Mar 15.

IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.

Objective: The objective of this study was the evaluation of the clinical and neurophysiological effects of intensive robot-assisted hand therapy compared to intensive occupational therapy in the chronic recovery phase after stroke.

Methods: 50 patients with a first-ever stroke occurred at least six months before, were enrolled and randomised into two groups. The experimental group was provided with the Amadeo™ hand training (AHT), whereas the control group underwent occupational therapist-guided conventional hand training (CHT). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.013DOI Listing
May 2019
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Bedside neurophysiological tests can identify neonates with stroke leading to cerebral palsy.

Clin Neurophysiol 2019 May 15;130(5):759-766. Epub 2019 Mar 15.

Department of Clinical Neurophysiology, Children's Hospital, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital (HUH), Helsinki, Finland.

Objective: The unspecific symptoms of neonatal stroke still challenge its bedside diagnosis. We studied the accuracy of routine electroencephalography (EEG) and simultaneously recorded somatosensory evoked potentials (EEG-SEP) for diagnosis and outcome prediction of neonatal stroke.

Methods: We evaluated EEG and EEG-SEPs from a hospital cohort of 174 near-term neonates with suspected seizures or encephalopathy, 32 of whom were diagnosed with acute ischemic or hemorrhagic stroke in MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193008
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http://dx.doi.org/10.1016/j.clinph.2019.02.017DOI Listing
May 2019
4 Reads

Quantitative electroencephalography characteristics of tilt-induced neurally-mediated syncope among youth.

Clin Neurophysiol 2019 May 15;130(5):752-758. Epub 2019 Mar 15.

Division of Pediatric Neurology, Nationwide Children's Hospital, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA.

Objective: To characterize the quantitative electroencephalographic (QEEG) patterns associated with tilt-induced syncope in youth.

Methods: Several QEEG parameters were analyzed. Data were calculated for peak or nadir changes with syncope for amplitude-EEG, fast Fourier transform (FFT) power in several frequency ranges, 8-13 Hz/1-4 Hz frequency ratio, and FFT edge. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.012DOI Listing
May 2019
2 Reads
3.097 Impact Factor

Deficits of visuospatial working memory and executive function in single- versus multiple-domain amnestic mild cognitive impairment: A combined ERP and sLORETA study.

Clin Neurophysiol 2019 May 23;130(5):739-751. Epub 2019 Feb 23.

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China; Department of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address:

Objective: According to recent criteria of classification, amnestic mild cognitive impairment (aMCI) could be divided into two categories: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The difference between sd-aMCI and md-aMCI needs further exploration. The present study aimed to compare deficits in visuospatial working memory (VSWM) and executive function between sd-aMCI versus md-aMCI patients by use of event-related potentials (ERP) and standardized low-resolution brain electromagnetic tomography analysis (sLORETA). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.025DOI Listing
May 2019
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Electrophysiological differences between upper and lower limb movements in the human subthalamic nucleus.

Clin Neurophysiol 2019 May 11;130(5):727-738. Epub 2019 Mar 11.

MRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Objective: Functional processes in the brain are segregated in both the spatial and spectral domain. Motivated by findings reported at the cortical level in healthy participants we test the hypothesis in the basal ganglia of Parkinson's disease patients that lower frequency beta band activity relates to motor circuits associated with the upper limb and higher beta frequencies with lower limb movements.

Methods: We recorded local field potentials (LFPs) from the subthalamic nucleus using segmented "directional" DBS leads, during which patients performed repetitive upper and lower limb movements. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.011DOI Listing

How does upper extremity Fugl-Meyer motor score relate to resting-state EEG in chronic stroke? A power spectral density analysis.

Clin Neurophysiol 2019 May 2;130(5):856-862. Epub 2019 Feb 2.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, de Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

Objective: We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke.

Methods: Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (Delta Alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.007DOI Listing
May 2019
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Temporal Characteristics of Attentional Disengagement from Emotional Facial Cues in Depression.

Neurophysiol Clin 2019 Mar 19. Epub 2019 Mar 19.

Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, 200030 Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Objectives: Studies have reported that depressed patients have difficulties in disengaging attention from negative information, but knowledge of the temporal characteristics of this disengagement is still rudimentary. Our objective is to reveal the temporal characteristics of attentional disengagement from emotional facial cues in depression.

Methods: We recruited 22 depressed patients and 22 healthy controls to participate in a cued target-response task with emotional facial expressions (happy, natural, and sad) as cues and three types of cue-target intervals (CTIs: 350ms, 1000ms, and 1500ms). Read More

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http://dx.doi.org/10.1016/j.neucli.2019.03.001DOI Listing
March 2019
1 Read

A-train clusters and the intermedius nerve in vestibular schwannoma patients.

Clin Neurophysiol 2019 May 15;130(5):722-726. Epub 2019 Mar 15.

Department of Neurosurgery, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.

Objective: EMG "A-train" activity correlates with postoperative facial palsy after vestibular schwannoma (VS) surgery. An intermedius nerve separate from the facial nerve increases A-trains without significant impact on function. We investigate occurrence of A-train "clusters", A-trains over a majority of channels within a short time frame. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.014DOI Listing

Different patterns of movement-related cortical oscillations in patients with myoclonus and in patients with spinocerebellar ataxia.

Clin Neurophysiol 2019 May 16;130(5):714-721. Epub 2019 Feb 16.

Department of Neurophysiopathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Objective: To assess whether different patterns of EEG rhythms during a Go/No-go motor task characterize patients with cortical myoclonus (EPM1) or with spinocerebellar ataxia (SCA).

Methods: We analyzed event-related desynchronization (ERD) and synchronization (ERS) in the alpha and beta-bands during visually cued Go/No-go task in 22 patients (11 with EPM1, 11 with SCA) and 11 controls.

Results: In the Go condition, the only significant difference was a reduced contralateral beta-ERS in the EPM1 patients compared with controls; in the No-go condition, the EPM1 patients showed prolonged alpha-ERD in comparison with both controls and SCA patients, and reduced or delayed alpha- and beta-ERS in comparison with controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.021DOI Listing

Prediction of postoperative motor deficits using motor evoked potential deterioration duration in intracranial aneurysm surgery.

Clin Neurophysiol 2019 May 7;130(5):707-713. Epub 2019 Mar 7.

Department of Neurophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: The study aimed to investigate the predictive value of motor evoked potential (MEP) deterioration duration for postoperative motor deficits in patients undergoing intracranial aneurysm surgery.

Methods: Data from 587 patients were reviewed and 92 patients with MEP deterioration were enrolled. MEP deterioration duration was compared between patients with and without postoperative motor deficits. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.010DOI Listing
May 2019
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Vestibular evoked myogenic potentials (VEMPs) in systemic disease.

Clin Neurophysiol 2019 May 6;130(5):789-790. Epub 2019 Mar 6.

Clinical Neurophysiology Laboratory, Clinic B, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.02.009DOI Listing
May 2019
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3.097 Impact Factor

Semi-quantitative electromyography as a predictor of nerve transfer outcome.

Clin Neurophysiol 2019 May 28;130(5):701-706. Epub 2019 Feb 28.

University of California San Diego School of Medicine, Department of Neurosciences, La Jolla, CA, USA.

Objectives: Evaluate correlation between donor nerve semi-quantitative electromyography (sqEMG) and strength outcome in nerve transfer surgery.

Methods: Retrospective review of pre-operative donor nerve semi-quantitative neurophysiology and post-operative recipient muscle force after at least one-year follow-up. The semi-quantitative technique is the average motor unit number estimate associated with needle recorded interference patterns in the donor muscle (IP-AMUNE), which was correlated with hand-held manometry, standardized as a percent of the contralateral arm, using multivariable linear regression with backward selection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193006
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http://dx.doi.org/10.1016/j.clinph.2019.02.008DOI Listing
May 2019
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Central fatigue and attentional processing in Parkinson's disease: An event-related potentials study.

Clin Neurophysiol 2019 May 12;130(5):692-700. Epub 2019 Feb 12.

Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy. Electronic address:

Objective: To verify whether central fatigue in patients with Parkinson's disease (PD) is associated with the presence of a more severe selective cognitive impairment.

Methods: Twenty-four PD patients without fatigue-PDnF, 11 with fatigue-PDF and 32 healthy volunteers underwent a P300 novelty task that elicits both the P3a and the P3b components.

Results: P3b latency was significantly longer in both PDF and PDnF than in controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.017DOI Listing

Eye movement abnormalities in essential tremor versus tremor dominant Parkinson's disease.

Clin Neurophysiol 2019 May 23;130(5):683-691. Epub 2019 Feb 23.

Department of Neurology and Clinical Neurophysiology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, the Netherlands. Electronic address:

Objective: To show that eye movement abnormalities differ between essential tremor (ET) and tremor dominant Parkinson's disease (PD-T), and that these abnormalities reflect cerebellar dysfunction in ET and basal ganglia pathology in PD-T.

Methods: In this exploratory study, in 23 patients with ET, 21 age-matched patients with PD-T, and 19 age-matched healthy controls (HCs), we investigated visually guided saccades, antisaccades, and smooth pursuit eye movements (SPEM).

Results: While the ET group had a normal gain (saccade amplitude/target amplitude) and latency of saccades, the PD-T group had hypometric visually guided saccades, and a prolonged latency of visually guided saccades and antisaccades. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.026DOI Listing
May 2019
5 Reads

Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients.

Clin Neurophysiol 2019 Feb 28. Epub 2019 Feb 28.

Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany. Electronic address:

Objectives: Botulinum neurotoxin serotypes A and B (BoNT/A & B) are highly effective medicines to treat hyperactive cholinergic neurons. Due to neutralizing antibody formation, some patients may become non-responders. In these cases, the serotypes BoNT/C-G might become treatment alternatives. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.007DOI Listing
February 2019
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Simultaneous MEG and EEG to detect ripples in people with focal epilepsy.

Clin Neurophysiol 2019 Feb 23. Epub 2019 Feb 23.

Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, UMC Utrecht, the Netherlands; SEIN - Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands.

Objective: We studied ripples (80-250 Hz) simultaneously recorded in electroencephalography (EEG) and magnetoencephalography (MEG) to evaluate the differences.

Methods: Simultaneous EEG and MEG were recorded in 30 patients with drug resistant focal epilepsy. Ripples were automatically detected and visually checked in virtual channels throughout the cortex. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.027DOI Listing
February 2019

Reduction of the event-related potential P3 in preterm born 5-year-old healthy children.

Clin Neurophysiol 2019 May 19;130(5):675-682. Epub 2019 Feb 19.

Clinical Neuropsychology, Ruhr University Bochum, Germany.

Objectives: An abbreviated gestational period may interrupt intrauterine brain development and constitutes a serious risk factor. Many preterm children show some form of attention deficits in later life. However, there is ambiguity about the nature and extent of these attention deficits in the literature. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.003DOI Listing

Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings.

Clin Neurophysiol 2019 May 21;130(5):666-674. Epub 2019 Feb 21.

Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital, St. Gallen, Switzerland.

Objective: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.

Methods: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193005
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http://dx.doi.org/10.1016/j.clinph.2019.01.020DOI Listing
May 2019
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Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control.

Clin Neurophysiol 2019 May 26;130(5):655-665. Epub 2019 Feb 26.

School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. Electronic address:

Objective: The study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the corticomotoneuronal pathway and manipulation of novel objects with the hand.

Methods: Three groups of adults aged 18-50 years were investigated: individuals with a history of illicit amphetamine use, individuals with a history of ecstasy use but minimal use of other stimulants, and non-drug users. Transcranial magnetic stimulation was delivered to the motor cortex and the electromyographic response (motor evoked potential; MEP) was recorded from a contralateral hand muscle. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.02.005DOI Listing
May 2019
3 Reads

Vestibular evoked myogenic potentials and their clinical utility in patients with amyotrophic lateral sclerosis.

Clin Neurophysiol 2019 May 21;130(5):647-654. Epub 2019 Feb 21.

Department of Neurology, Peking University Third Hospital, Beijing, China; Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking University, Beijing, China. Electronic address:

Objective: To evaluate the diagnostic value of vestibular evoked myogenic potentials (VEMPs) in the assessment of brainstem function integrity in patients with amyotrophic lateral sclerosis (ALS).

Methods: This was a prospective case-control study including 30 definite or probable ALS patients divided into two groups (with or without brainstem involvement) and 30 healthy controls. Cervical (c-), masseter (m-) and ocular VEMP (o-VEMP) measurements were obtained for all the participants. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.023DOI Listing
May 2019
3 Reads