7,557 results match your criteria Clinical Neurophysiology[Journal]


Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence.

Clin Neurophysiol 2019 Jan 18;130(4):484-490. Epub 2019 Jan 18.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

Objectives: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism.

Methods: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning. According to the ECF state, patients were assigned to normal and impaired ECF groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.007DOI Listing
January 2019

Prolonged cortical silent period is related to poor fitness and fatigue, but not tumor necrosis factor, in Multiple Sclerosis.

Clin Neurophysiol 2019 Feb 4;130(4):474-483. Epub 2019 Feb 4.

Recovery and Performance Laboratory, Faculty of Medicine, L.A. Miller Centre, Memorial University of Newfoundland, St. John's, NL, Canada. Electronic address:

Objective: Poor fitness among people with Multiple Sclerosis (MS) aggravates disease symptoms. Whether low fitness levels accompany brain functioning changes is unknown.

Methods: MS patients (n = 82) completed a graded maximal exercise test, blood was drawn, and transcranial magnetic stimulation determined resting and active motor thresholds, motor evoked potential latency, and cortical silent period (CSP). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.015DOI Listing
February 2019

Subthalamic and pallidal oscillatory activity in patients with Neurodegeneration with Brain Iron Accumulation type I (NBIA-I).

Clin Neurophysiol 2019 Jan 25;130(4):469-473. Epub 2019 Jan 25.

Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure, ExzellenzCluster, Charité - Universitätsmedizin Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objectives: Neurodegeneration with Brain Iron Accumulation type I (NBIA-I) is a rare hereditary neurodegenerative disorder with pallidal degeneration leading to disabling generalized dystonia and parkinsonism. Pallidal or subthalamic deep brain stimulation can partially alleviate motor symptoms. Disease-specific patterns of abnormally enhanced oscillatory neuronal activity recorded from the basal ganglia have been described in patients with movement disorders undergoing deep brain stimulation (DBS). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.012DOI Listing
January 2019

Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.

Clin Neurophysiol 2019 Jan 31;130(4):454-468. Epub 2019 Jan 31.

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Objective: The flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints.

Methods: Twelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.010DOI Listing
January 2019

EEG and MEG source imaging for epilepsy surgery - A sobering 22-year interim report.

Authors:
Chris Plummer

Clin Neurophysiol 2019 Feb 10. Epub 2019 Feb 10.

Centre for Neurosciences and Neurological Research, St Vincent's Hospital, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.02.001DOI Listing
February 2019

Latent ERP components of cognitive dysfunctions in ADHD and schizophrenia.

Clin Neurophysiol 2019 Feb 10;130(4):445-453. Epub 2019 Feb 10.

Brain and Trauma Foundation, Grison, and Praxis für Kind, Organisation und Entwicklung, Chur, Switzerland.

Objective: The main goal was to assess common and specific deficits of cognitive control in (Attention Deficit Hyperactivity Disorder) ADHD and schizophrenia (SZ) using event-related potentials (ERPs).

Method: Behavioral and EEG data in cued GO/NOGO task were recorded in 132 healthy controls (HC) and age, gender and education matched 63 ADHD adults, and 68 SZ patients.

Results: N2d wave in NOGO-GO contrast of ERPs did not differ between the groups while the P3d wave discriminated SZ group from two other groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.015DOI Listing
February 2019

Cortical inhibitory dysfunction in epilepsia partialis continua: A high frequency oscillation somatosensory evoked potential study.

Clin Neurophysiol 2019 Jan 25;130(4):439-444. Epub 2019 Jan 25.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy. Electronic address:

Objective: The pathophysiology of epilepsia partialis continua (EPC) is still unclear, a thalamo-cortical circuit dysfunction has been hypothesized. The aim of present study is the functional evaluation of the thalamo-cortical network in EPC by means of the study of low- and high-frequency somatosensory evoked potentials (LF-SEP and HF-SEP).

Methods: Median LF-SEP and HF-SEP were recorded in 3 patients with EPC and in 2 patients with rolandic lesions without EPC (non-EPC). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.005DOI Listing
January 2019

Widespread interictal epileptic discharge more likely than focal discharges to unveil the seizure onset zone in EEG-fMRI.

Clin Neurophysiol 2019 Jan 30;130(4):429-438. Epub 2019 Jan 30.

Montreal Neurological Institute and Hospital, McGill University, Canada.

Objective: We hypothesized that the number of interictal epileptic discharges (IEDs) during scan and their spatial extent are contributing factors in obtaining appropriate activations that reveal the seizure onset zone (SOZ) in EEG-fMRI.

Methods: 157 IED types, each corresponding to one EEG scalp distribution, in 64 consecutive EEG-fMRI studies from 64 patients with refractory localization-related epilepsy were reviewed. To determine reliable activation, we used the threshold corresponding to corrected whole-brain topological false discovery rate (FDR). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.014DOI Listing
January 2019

Brainstem avenues in Parkinson's disease research.

Clin Neurophysiol 2019 Feb 6. Epub 2019 Feb 6.

Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy.

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http://dx.doi.org/10.1016/j.clinph.2019.01.013DOI Listing
February 2019

Preventing nerve injury with pedicle screw testing.

Authors:
Marc R Nuwer

Clin Neurophysiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA; Department of Clinical Neurophysiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095 USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.01.006DOI Listing
January 2019

Linking invasive and noninvasive neuromodulation techniques to study network properties of the brain.

Clin Neurophysiol 2019 Jan 18. Epub 2019 Jan 18.

Movement Disorder and Neuromodulation Unit, Dept. of Neurology, Charité Universitaetsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.12.006DOI Listing
January 2019

Nerve ultrasound as a diagnostic tool for sensory neuronopathy in spinocerebellar ataxia syndrome.

Clin Neurophysiol 2019 Jan 19. Epub 2019 Jan 19.

Department of Neurology and Clinical Neurophysiology, Bay of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand.

Objective: The objective was to assess if nerve ultrasound has a role in diagnosing sensory neuronopathy in spinocerebellar ataxia syndrome (SCA) by examining if proposed diagnostic cut-off criteria of ultrasound in sensory neuronopathy caused by cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) were also discriminatory for SCA-related sensory neuronopathy.

Methods: Optimal diagnostic cut-off criteria for nerve size measured by diagnostic ultrasound were developed in 14 patients with CANVAS and 42 healthy controls using six peripheral nerve sites; and logistic regression and receiver operating characteristic (ROC) curves. These proposed cut-off values were tested in seven patients with spinocerebellar ataxia type 2 (SCA2) patients with sensory neuronopathy. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.010DOI Listing
January 2019

Electroencephalographic features associated with intermittent rhythmic delta activity.

Neurophysiol Clin 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

Objective: To investigate the clinical importance of intermittent rhythmic delta activity (IRDA) in terms of accompanying electrophysiological findings on EEG and their association with IRDA.

Methods: We retrospectively assessed all EEG studies recorded in our institution from 2011 to 2017. Patients with intermittent rhythmic delta activity (IRDA) in EEGs were included. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.036DOI Listing
January 2019

Efficacy of high-frequency (15Hz) repetitive transcranial magnetic stimulation (rTMS) of the left premotor cortex/dorsolateral prefrontal cortex in decreasing cocaine intake (the MagneTox study): A study protocol for a randomized placebo-controlled pilot trial.

Neurophysiol Clin 2019 Feb 26;49(1):1-9. Epub 2018 Oct 26.

SODc Neurofisiopatologia, Dipartimento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, Firenze, Italy; IRCCS, Fondazione Don Carlo Gnocchi, Firenze, Italy. Electronic address:

Background: Cocaine use disorder (CUD) is very common and has psychological and physical consequences. Patients with CUD present hypoactivity of the prefrontal cortical area. Thus, excitatory repetitive transcranial magnetic stimulation (rTMS) targeting the premotor cortex/dorsolateral prefrontal cortex (PMC/DLPFC), given its ability to increase prefrontal area excitability and to modulate cortico-limbic activity, could result in a decrease in cocaine intake. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.10.002DOI Listing
February 2019

Similarities and differences between the interictal epileptiform discharges of green-spikes and red-spikes zones of human neocortex.

Authors:
Ruggero Serafini

Clin Neurophysiol 2019 Mar 19;130(3):396-405. Epub 2019 Jan 19.

Department of Neurology, University of Utah, Clinical Neuroscience Center, George E. Wahlen VA Medical Center, Salt Lake City, UT, USA. Electronic address:

Objective: This study looks for differences in the waveforms of interictal epileptiform discharges (IEDs) between cortices expressing only isolated discharges (green-spikes zones) vs those manifesting seizures (red-spikes zones): these can help to understand ictogenesis mechanisms and improve clinical decision in surgical epilepsy. Typical IEDs are triphasic, exhibiting in sequence: a negative-sharp-wave, a positive-baseline-shift and a negative-slow-wave. Negative-slow-waves are thought to reflect neurophysiological inhibition: their features at a focus' edge may reflect peripheral inhibition, a mechanism characterized in experimental models, curbing seizures' spread. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.011DOI Listing

Postural responses to emotional visual stimuli.

Neurophysiol Clin 2019 Jan 30. Epub 2019 Jan 30.

EA 4559, Laboratoire de Neurosciences Fonctionnelles et Pathologies, Centre Universitaire de Recherche en Santé, rue René-Laennec, 80054 Amiens cedex 1, France.

Postural control is a motor skill that allows individuals to interact with their environment. Indeed, in all species, development of postural control is a prerequisite for acquiring further motor abilities. In humans, the maintenance of a bipedal posture plays an important role in interaction with the environment, as it provides a stable postural basis allowing upper limbs and hands to be used to manipulate objects. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.005DOI Listing
January 2019

Gait quantification in multiple sclerosis: A single-centre experience of systematic evaluation.

Neurophysiol Clin 2019 Jan 30. Epub 2019 Jan 30.

Laboratoire d'exploration fonctionnelle clinique du mouvement, university hospital of Besançon, 25000 Besançon, France; Integrative and clinical neurosciences EA481, Bourgogne Franche-Comte university, 25000 Besançon, France.

Gait disorders can be disabling in persons with multiple sclerosis (PMS). Different gait parameters have been used to evaluate gait disorders according to the International classification of functioning. Some authors have reported a direct relation between evaluations over short distances and long-term outcomes. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.004DOI Listing
January 2019

Three-dimensional amplitude characteristics of masseter motor units and representativeness of extracted motor unit samples.

Clin Neurophysiol 2019 Mar 19;130(3):388-395. Epub 2019 Jan 19.

Department of Orthodontics, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany; Department of Clinical Physics, Kempenhaeghe Epilepsy and Sleep Center, Sterkselseweg 65, 5591 VE Heeze, the Netherlands.

Objective: This study aimed to characterize amplitude topographies for masseter motor units (MUs) three-dimensionally, and to assess whether high-density surface electromyography (HDsEMG) is able to detect MU samples that represent the masseter's entire MU pool.

Methods: Ten healthy adult volunteers participated in the study, which combined three EMG techniques. A HDsEMG grid covering the entire masseter, and intramuscular fine-wire electrodes were used to obtain two independent MU samples for comparison. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.008DOI Listing
March 2019
4 Reads

Assessing blink reflex circuits by three different afferent routes in Parkinson's disease.

Clin Neurophysiol 2019 Jan 19. Epub 2019 Jan 19.

Department of Neurology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.

Objective: Degeneration of nuclei of the brainstem, especially parts of the vagal nuclei complex and the reticular formation, in Parkinson's disease (PD) may in part be responsible for nonmotor signs like obstipation, cardiac dysfunction and rapid eye movement sleep behavior disorder (RBD). The aim of the study was to establish a new blink reflex (BR) variant involving the vagal nuclei complex and the reticular formation and to investigate BR comprehensively using 3 different afferent routes in PD.

Methods: In this cross-sectional observational study in 30 PD patients and 30 age and sex matched healthy controls, BR was elicited by stimulation of the auricular branch of the vagus nerve (ABVN) and compared to conventional BR variants evoked by the trigeminal and median nerve. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.009DOI Listing
January 2019

Cutaneous silent periods - Part 2: Update on pathophysiology and clinical utility.

Clin Neurophysiol 2019 Jan 18. Epub 2019 Jan 18.

Unitat d'Electromiografia, Servei de Neurologia, Hospital Clínic, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Universitat de Barcelona, Hospital Clinic I Provincial de Barcelona, Spain.

Testing of exteroceptive electromyographic modulation of ongoing voluntary muscle activity is of increasing interest as a diagnostic tool in clinical neurophysiology. The cutaneous silent period (CSP) is a robust and reproducible nociceptive EMG suppression, mediated at the spinal level by small-diameter A-delta afferents. The techniques and physiological principles of CSP testing, which are a fundamental prerequisite for a valid and thoughtful clinical application, are reviewed separately in part 1 (Kofler et al. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.003DOI Listing
January 2019
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Cutaneous silent periods - Part 1: Update on physiological mechanisms.

Clin Neurophysiol 2019 Jan 18. Epub 2019 Jan 18.

Unitat d'Electromiografia, Servei de Neurologia, Hospital Clínic, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Universitat de Barcelona, Hospital Clinic I Provincial de Barcelona, Spain.

Testing of exteroceptive electromyographic modulation of ongoing voluntary muscle activity is of interest in normal human physiology and in diagnostic clinical neurophysiology in normal and pathological conditions. The cutaneous silent period (CSP) is a robust and reproducible nociceptive EMG suppression, mediated at the spinal level by small-diameter A-delta afferents. This critical review surveys the literature on applied stimulation and recording techniques, physiological principles, involved fiber types, spinal circuitry, supraspinal modulation, neurotransmitters and pharmacology of CSPs. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.002DOI Listing
January 2019

Boosting physical exercise with cortical stimulation or brain doping using tDCS: Fact or myth?

Neurophysiol Clin 2019 Jan 24. Epub 2019 Jan 24.

EA 4391, faculté de médecine de Créteil, université Paris Est Créteil, 94010 Créteil, France; Service de physiologie - explorations fonctionnelles, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 94010 Créteil, France. Electronic address:

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http://dx.doi.org/10.1016/j.neucli.2019.01.002DOI Listing
January 2019

Boosting brain motor plasticity with physical exercise.

Neurophysiol Clin 2019 Jan 24. Epub 2019 Jan 24.

Inserm U1171 - troubles dégénératifs cognitifs et vasculaires, université Lille, 59000 Lille, France; Rééducation neurologique, CHU Lille, 59000 Lille, France.

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http://dx.doi.org/10.1016/j.neucli.2019.01.003DOI Listing
January 2019

Posturo-locomotor markers of preclinical Parkinson's disease.

Neurophysiol Clin 2019 Jan 24. Epub 2019 Jan 24.

Normandie University, UNICAEN, INSERM, COMETE, 14000 Caen, France.

Parkinson's disease (PD) is known to have a long prodromal stage due to the degeneration of dopaminergic neurons of the substantia nigra pars compacta over the course of many years without clinical manifestations of PD. When the diagnosis is made, the neuropathological process is already well entrenched. Consequently, identifying individuals during this prodromal period could be very helpful for future trials of neuroprotective or disease-modifying therapies, which might slow or prevent the degeneration of dopaminergic neurons. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.001DOI Listing
January 2019
1 Read

Nerve ultrasound in dorsal root ganglion disorders: Smaller nerves lead to bigger insights.

Authors:
Nens van Alfen

Clin Neurophysiol 2019 Jan 19. Epub 2019 Jan 19.

Radboud University Medical Center, Department of Neurology and Clinical Neurophysiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.01.004DOI Listing
January 2019

Beyond Jeannerod's motor simulation theory: An approach for improving post-traumatic motor rehabilitation.

Authors:
Claire Calmels

Neurophysiol Clin 2019 Jan 23. Epub 2019 Jan 23.

Laboratory Sport, Expertise and Performance (EA 7370), Research Department, French Institute of Sport (INSEP), 75012 Paris, France. Electronic address:

This paper depicts an approach aiming to allow individuals with orthopedic trauma injuries to optimize recovery and safely return to daily life. The core of this approach is motor simulation, used in complement to conventional physical rehabilitation methods. This paper provides recent scientific insights on the basis of motor simulation, discusses benefits of this approach in motor rehabilitation, and provides applied perspectives. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.033DOI Listing
January 2019
1 Read

Scotopic multifocal visual evoked potentials.

Clin Neurophysiol 2019 Mar 31;130(3):379-387. Epub 2018 Dec 31.

Department of Ophthalmology, Otto-von-Guericke University Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany. Electronic address:

Objective: To investigate the scope of scotopic multifocal visual evoked potentials (mfVEP) for the assessment of scotopic visual fields.

Methods: Pattern-reversal mfVEP for photopic (mfVEP) and scotopic conditions (mfVEP; 0.003 cd/m) were recorded from 36 visual field locations of a circular checkerboard pattern (25° radius) in 9 participants with normal vision. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.030DOI Listing

Hepatic encephalopathy revisited: Beyond the triphasic waves.

Clin Neurophysiol 2019 Mar 20;130(3):408-409. Epub 2018 Dec 20.

Department of Neurology, Utano National Hospital, National Hospital Organization, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.clinph.2018.12.003DOI Listing
March 2019
1 Read

Towards fast and reliable simultaneous EEG-fMRI analysis of epilepsy with automatic spike detection.

Clin Neurophysiol 2019 Mar 17;130(3):368-378. Epub 2018 Dec 17.

The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, VIC, Australia; Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, VIC, Australia; Department of Neurology, Austin Health, Melbourne, VIC, Australia. Electronic address:

Objective: The process of manually marking up epileptic spikes for simultaneous electroencephalogram (EEG) and resting state functional MRI (rsfMRI) analysis in epilepsy studies is a tedious and subjective task for a human expert. The aim of this study was to evaluate whether automatic EEG spike detection can facilitate EEG-rsfMRI analysis, and to assess its potential as a clinical tool in epilepsy.

Methods: We implemented a fast algorithm for detection of uniform interictal epileptiform discharges (IEDs) in one-hour scalp EEG recordings of 19 refractory focal epilepsy datasets (from 16 patients) who underwent a simultaneous EEG-rsfMRI recording. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.024DOI Listing

Force decline after low and high intensity contractions in persons with multiple sclerosis.

Clin Neurophysiol 2019 Mar 27;130(3):359-367. Epub 2018 Dec 27.

Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Objective: Force decline during strong contractions is dominated by changes in the periphery whereas during weaker contraction changes in voluntary activation become more important. We compared force decline and contributing factors in persons with multiple sclerosis (PwMS) during low and high intensity contractions.

Methods: Index finger abduction force, force evoked by electrical stimulation of the ulnar nerve at rest (RTw), and during MVCs were investigated in 19 PwMS and 19 controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.027DOI Listing
March 2019
1 Read

From research to clinic: A sensor reduction method for high-density EEG neurofeedback systems.

Clin Neurophysiol 2019 Mar 16;130(3):352-358. Epub 2018 Dec 16.

Center for Mindfulness, University of Massachusetts Medical School, 222 Maple St., Shrewsbury, MA 01545, USA.

Objective: To accurately deliver a source-estimated neurofeedback (NF) signal developed on a 128-sensors EEG system on a reduced 32-sensors EEG system.

Methods: A linearly constrained minimum variance beamformer algorithm was used to select the 64 sensors which contributed most highly to the source signal. Monte Carlo-based sampling was then used to randomly generate a large set of reduced 32-sensors montages from the 64 beamformer-selected sensors. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.023DOI Listing

Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy.

Clin Neurophysiol 2019 Mar 28;130(3):341-351. Epub 2018 Dec 28.

Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Japan.

Objective: Patients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE.

Methods: Eighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183140
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http://dx.doi.org/10.1016/j.clinph.2018.11.026DOI Listing
March 2019
5 Reads

Investigating dynamic functional network patterns after propofol-induced loss of consciousness.

Clin Neurophysiol 2019 Mar 27;130(3):331-340. Epub 2018 Dec 27.

School of Life Science and Technology, Xidian University, Xi'an, China. Electronic address:

Objective: We investigated the changes of dynamic brain functional network from awaken state to the anesthesia level suitable for surgery.

Methods: 60-channel EEG data of 22 subjects are acquired at wakefulness, light anesthesia and deep anesthesia. The activity of 68 cortical regions are obtained by using EEG source imaging. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.028DOI Listing
March 2019
3 Reads

The diagnostic accuracy of high-resolution ultrasound in screening for carpal tunnel syndrome and grading its severity is moderated by age.

Clin Neurophysiol 2019 Mar 31;130(3):321-330. Epub 2018 Dec 31.

Department of Neurology, School of Medicine, University of Patras, Greece.

Objective: To assess the effect of age on the accuracy of high-resolution ultrasound (HRUS) in the diagnosis and grading of carpal tunnel syndrome (CTS).

Methods: Patients with symptoms and signs of CTS (N = 527 wrists) were evaluated using electrodiagnostic studies (EDx) for CTS diagnosis and grading. Median nerve cross-sectional areas at carpal tunnel inlet (CSA) and at forearm level were measured by HRUS and the ratio of these values was calculated (WFR). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.005DOI Listing
March 2019
2 Reads

How can the stimulation of plantar cutaneous receptors improve postural control? Review and clinical commentary.

Neurophysiol Clin 2019 Jan 10. Epub 2019 Jan 10.

Laboratoire d'automatique, de mécanique et d'informatique industrielles et humaines (LAMIH), UMR CNRS 8201, université de Valenciennes et du Hainaut-Cambrésis (UVHC), 59313 Valenciennes, France; Posture Lab, 75012 Paris, France.

Postural control requires constant and subconscious postural sway to manage balance and achieve postural stability. These movements of regulation are based in particular on cutaneous plantar information. The foot constitutes a functional whole that participates in the mechanisms of postural control and regulation. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.006DOI Listing
January 2019
1 Read

Safety and effects on motor cortex excitability of five anodal transcranial direct current stimulation sessions in 24hours.

Neurophysiol Clin 2019 Feb 8;49(1):19-25. Epub 2019 Jan 8.

Department of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio", via L. Polacchi 11, 66100 Chieti, Italy. Electronic address:

Background And Objective: Application parameters of transcranial direct current stimulation (tDCS) for therapeutic purposes are relatively restricted. The aim of this study was to assess safety and effects on motor cortex excitability of an intensive anodal-tDCS protocol.

Methods: In 26 healthy subjects, five 15-minute anodal-tDCS sessions were delivered, at increasing time intervals, over 24hours. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.003DOI Listing
February 2019
6 Reads

Coaching of lifestyle recommendations improves sensory neurophysiological parameters in neuropathies related to glycemic disorder or metabolic syndrome. A pilot study.

Neurophysiol Clin 2019 Feb 4;49(1):59-67. Epub 2019 Jan 4.

EA 4391, Faculté de médecine de Créteil, Université Paris Est Créteil, 94010 Créteil, France; Service de neurologie, Groupe hospitalier Henri-Mondor, Centre hospitalier universitaire Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Objectives: Metabolic abnormalities, such as, glycemic disorders and metabolic syndrome (GDMS) are one of the main causes of peripheral neuropathies. The objective of this study was to evaluate the impact of adding specific coaching care (CC) to standard care (SC) of therapeutic education based on lifestyle recommendations for neuropathies associated with GDMS.

Methods: This prospective randomized study included two groups of four patients (SC vs. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.004DOI Listing
February 2019
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Exploration of autonomic activity in narcolepsy: The riddle remains unsolved.

Clin Neurophysiol 2019 Mar 27;130(3):406-407. Epub 2018 Dec 27.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.12.004DOI Listing
March 2019
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Focal hole versus screw stimulation to prevent false negative results in detecting pedicle breaches during spinal instrumentation.

Clin Neurophysiol 2018 Dec 26. Epub 2018 Dec 26.

Department of Neurosurgery, Clinica Fornaca di Sessant, Corso Vittorio Emanuele II, 10128 Turin, Italy. Electronic address:

Objective: We describe a stimulus-evoked EMG approach to minimize false negative results in detecting pedicle breaches during lumbosacral spinal instrumentation.

Methods: In 36 patients receiving 176 lumbosacral pedicle screws, EMG threshold to nerve root activation was determined using a focal probe inserted into the pilot hole at a depth, customized to the individual patients, suitable to position the stimulating tip at the point closest to the tested nerve root. Threshold to screw stimulation was also determined. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.029DOI Listing
December 2018
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EEG analysis in anti-NMDA receptor encephalitis: Description of typical patterns.

Clin Neurophysiol 2019 Feb 29;130(2):289-296. Epub 2018 Nov 29.

Department of Neurology, University Hospital Center of Saint-Etienne, France; NeuroPain Lab, Lyon Neuroscience Research Centre, CRNL-InsermU 1028/CNRS UMR5292, University of Lyon, France. Electronic address:

Objective: To describe different electroencephalogram (EEG) patterns and epileptic features in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE), their timeline in the course of the disease, their correlation with clinical data and outcome.

Methods: We retrospectively analyzed EEG recordings between November 2007 and June 2016 in 24 consecutive patients.

Results: Three EEG patterns were described: Excessive Beta Activity range 14-20 Hz (EBA) in 71% of patients, Extreme Delta Brush (EDB) in 58% and Generalized Rhythmic Delta Activity (GRDA) in 50%. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.10.017DOI Listing
February 2019
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Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker.

Clin Neurophysiol 2019 Feb 6;130(2):280-288. Epub 2018 Dec 6.

Department of Neurosurgery, Yale University, P.O. Box 208082, New Haven, CT 06520-8082, USA; Department of Neurosurgery, Northwestern University, 676 N. Saint Clair, Suite 2210, Chicago, IL 60611, USA. Electronic address:

Objective: Localization related epilepsy (LRE) is increasingly accepted as a network disorder. To better understand the network specific characteristics of LRE, we defined individual epilepsy networks and compared them across patients.

Methods: The epilepsy network was defined in the slow cortical potential frequency band in 10 patients using intracranial EEG data obtained during interictal periods. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.016DOI Listing
February 2019
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Interictal spike connectivity in human epileptic neocortex.

Clin Neurophysiol 2019 Feb 19;130(2):270-279. Epub 2018 Dec 19.

Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL, United States. Electronic address:

Objective: Interictal spikes are a biomarker of epilepsy, yet their precise roles are poorly understood. Using long-term neocortical recordings from epileptic patients, we investigated the spatial-temporal propagation patterns of interictal spiking.

Methods: Interictal spikes were detected in 10 epileptic patients. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.025DOI Listing
February 2019
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Contribution of transcranial magnetic stimulation in assessing parietofrontal connectivity during gesture production in healthy individuals and brain-injured patients.

Neurophysiol Clin 2018 Dec 29. Epub 2018 Dec 29.

Inserm U1171, University Lille, Degenerative and Vascular Cognitive Disorders, 59000 Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, 59000 Lille, France.

Parietofrontal (PF) networks link the posterior parietal cortex to premotor and prefrontal areas, and are involved in the control of many motor and cognitive behaviors in healthy humans. In recent years, electrophysiological experiments have provided a better understanding of the functional specificity and temporal involvement of the PF networks' different components during the planning of visually guided upper limb movements. In particular, transcranial magnetic stimulation has been used to temporarily inactivate a cortical area (virtual lesions) or to assess connectivity using paired-pulse protocols)). Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.005DOI Listing
December 2018
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Reliability of maximum isometric hip and knee torque measurements in children with cerebral palsy using a paediatric exoskeleton - Lokomat.

Neurophysiol Clin 2018 Dec 23. Epub 2018 Dec 23.

École de kinésiologie, Faculté de Médecine, Université de Montréal, 2100, boul. Édouard-Montpetit, H3T 1J4 Montréal, Québec, Canada; Centre de réadaptation Marie-Enfant, CHU Sainte-Justine, 5200, rue Bélanger, H1T 1C9 Montréal, Québec, Canada.

Background: The Lokomat (by L-Force tool) allows the measurement of the maximum voluntary isometric torque (MVIT) at the knee and hip joints in a standing position, as close as possible to the posture adopted during walking. However, the reliability of this measurement in children with cerebral palsy (CP) remains unknown. The main goal of this study was to evaluate inter and intra-tester reliability of a novel tool (L-Force) in CP population. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.001DOI Listing
December 2018
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Increased EMG intermuscular coherence and reduced signal complexity in Parkinson's disease.

Clin Neurophysiol 2019 Feb 8;130(2):259-269. Epub 2018 Dec 8.

School of Electrical & Electronic Engineering, University College Dublin, Belfield, Dublin 4, Ireland; Insight Centre for Data Analytics, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Objectives: To investigate differences in surface electromyography (EMG) features in individuals with idiopathic Parkinson's disease (PD) and aged-matched controls.

Methods: Surface EMG was recorded during isometric leg extension in PD patients prior to, and after undergoing a locomotor training programme, and in aged-matched controls. Differences in EMG structure were quantified using determinism (%DET), sample entropy (SampEn) and intermuscular coherence. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.10.023DOI Listing
February 2019
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Inter-ictal network of focal epilepsy and effects of clinical factors on network activity.

Clin Neurophysiol 2019 Feb 16;130(2):251-258. Epub 2018 Dec 16.

University of Debrecen, Medical Center, Department of Neurology, Móricz Zsigmond krt. 22., 4032 Debrecen, Hungary.

Objective: Aim of the study was to explore the inter-ictal, resting-state EEG network in patients with focal epilepsy (FE) and to specify clinical factors that influence network activity.

Methods: Functional EEG connectivity (EEGfC) differences were computed between 232 FE patients (FE group) and 77 healthy controls. EEGfC was computed among 23 cortical regions within each hemisphere, for 25 very narrow bands from 1 to 25 Hz. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.022DOI Listing
February 2019
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Neuropathic pain, dysautonomia, and nerve hyperexcitability: Expanding the spectrum of LGI1 autoimmunity.

Clin Neurophysiol 2019 Feb 7;130(2):248-250. Epub 2018 Dec 7.

AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2-Mazarin et Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), UMRS 975, Paris 75013, France; Inserm U 975, CNRS, UMR 7225, Paris 75013, France; Centre de Compétence des Syndromes Neurologiques Paraneoplasiques et Encéphalites Autoimmunes, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.clinph.2018.11.017DOI Listing
February 2019
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Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint.

Clin Neurophysiol 2019 Feb 3;130(2):239-247. Epub 2018 Dec 3.

Masaryk University, Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, and Movement Disorders Centre, Brno, Czech Republic. Electronic address:

Clinical symptoms of Parkinson's disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.013DOI Listing
February 2019
1 Read