5,576 results match your criteria Clinical Neurology and Neurosurgery[Journal]


The effects of hyperglycemia on outcomes in surgical high-grade glioma patients.

Clin Neurol Neurosurg 2019 Feb 11;179:9-13. Epub 2019 Feb 11.

Lillian S. Wells Department of Neurosurgery, 1600 S.W. Archer Road, University of Florida, Gainesville, FL, 32608, United States.

Objective: To define the glucose values associated with an increase in complication rates in post-operative brain tumor patients.

Patients And Methods: Patients who underwent craniotomy for resection of WHO Grade III or IV glioma from 2011 to 2014 were retrospectively reviewed. Post-operative blood glucose values were recorded for post-operative day #0, #1, and #2. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.011DOI Listing
February 2019

The impact of BMI on operating room time, blood loss, and hospital stay in patients undergoing spinal fusion.

Clin Neurol Neurosurg 2019 Feb 11;179:19-22. Epub 2019 Feb 11.

Boulder Neurosurgical Associates, Boulder, CO, United States; Justin Parker Neurological Institute, Boulder, CO, United States. Electronic address:

Objective: Obesity affects not only the health of an individual but society as a whole and especially the healthcare system. Healthcare providers are faced with challenges to deliver adequate care in this resource-limited environment, assure safety, and accommodate the increasing population of overweight patients. The effects of increased body mass index (BMI) on clinical outcomes, complications, health care resource utilization, effectiveness of minimally invasive approaches, and perioperative parameters in spine surgeries have all been previously studied, but the majority of these findings are conflicting rather than conclusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193003
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http://dx.doi.org/10.1016/j.clineuro.2019.02.012DOI Listing
February 2019
1 Read

Symptomatic radiation necrosis in brain metastasis patients treated with stereotactic radiosurgery and immunotherapy.

Clin Neurol Neurosurg 2019 Feb 11;179:14-18. Epub 2019 Feb 11.

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States. Electronic address:

Objectives: The association of symptomatic radiation necrosis (RN) with stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs) in brain metastases patients has been incompletely explored. We aim to discuss the incidence, risk factors, and prognosis of symptomatic RN in patients treated with these modalities.

Patients And Methods: We retrospectively evaluated the incidence of symptomatic RN among all patients with brain metastases treated with both SRS and an ICI at a single academic center. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.010DOI Listing
February 2019

Early management of poor-grade aneurysmal subarachnoid hemorrhage: A prognostic analysis of 104 patients.

Clin Neurol Neurosurg 2019 Feb 5;179:4-8. Epub 2019 Feb 5.

Department of Neurosurgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China. Electronic address:

Objective: This study aimed to investigate the efficacy of early management for poor-grade aneurysmal subarachnoid hemorrhage (aSAH; WFNS grade IV and V), and analyze the prognostic factors.

Patients And Methods: A total of 104 consecutive patients with poor-grade aSAH from the Department of Neurosurgery, the Second Hospital of Shandong University were enrolled between January 2010 and December 2017. All these patients underwent early microsurgical clipping or endovascular coiling within three days after onset. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.003DOI Listing
February 2019

A rare cause of axial worsening in Parkinson's disease: A case of myasthenic pseudo-parkinsonism.

Clin Neurol Neurosurg 2019 Feb 11;179:1-3. Epub 2019 Feb 11.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.

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http://dx.doi.org/10.1016/j.clineuro.2019.02.009DOI Listing
February 2019

Is there a relationship between basilar artery tortuosity and vertigo?

Clin Neurol Neurosurg 2019 Mar 6;178:97-100. Epub 2019 Feb 6.

Kirikkale University, Faculty of Medicine, Department of Radiology, Kirikkale, Turkey.

Objective: The aim of this study was to investigate the relationship between basilar artery (BA) tortuosity, hypogenesis/agenesis of the vertebral artery (VA), and vertigo, with the use of magnetic resonance imaging (MRI).

Patients And Methods: This case-control study included patients admitted to the outpatient clinics, who were aged 18-80 years, without any known systemic diseases. All patients were evaluated with a 1. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.006DOI Listing
March 2019
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Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Mar 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
March 2019
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Modified encephalo-duro-periosteal-synangiosis (EDPS) for the revascularization of anterior cerebral artery territory in moyamoya disease: A single-center experience.

Clin Neurol Neurosurg 2019 Mar 4;178:86-92. Epub 2019 Feb 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Road, Beijing, 100070, China. Electronic address:

Objectives: Anterior cerebral artery (ACA) territory, a crucial area of intellectual development in children, is frequently involved in the progress of moyamoya disease (MMD). However, revascularization surgeries for this area are not as established as surgeries for middle cerebral artery (MCA) territory. This study aimed to describe our experience and study the effect of revascularizing ACA territory with periocranium and dural leaflets, which is referred to as 'encephalo-duro-periosteal-synangiosis (EDPS)'. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.002DOI Listing

Impact of morbid obesity (BMI > 40 kg/m) on complication rate and outcome following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF).

Clin Neurol Neurosurg 2019 Mar 4;178:82-85. Epub 2019 Feb 4.

Department of Neurosurgery, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Objectives: The negative effects of obesity on the health and quality of life of those afflicted has become an important public concern. Previous studies have shown an association between obesity and higher rates of complications and unfavorable outcomes following spine surgery. This study is to identify peri- and postoperative complication rates as well as short-term and long-term outcomes in morbidly obese patients who underwent minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) in comparison to age-matched normal-weight patients. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.004DOI Listing
March 2019
2 Reads

Where to stop distally in Lenke modifier C AIS with lumbar curve more than 60°: L3 or L4?

Clin Neurol Neurosurg 2019 Mar 5;178:77-81. Epub 2019 Feb 5.

Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China. Electronic address:

Objective: Selecting lowest instrumented vertebra (LIV) in adolescent idiopathic scoliosis (AIS) with large lumbar curve can be difficult. Stopping the distal fusion at L3 could save more mobile lumbar segments but may increase the risk of decompensation. This study was designed to evaluate preoperative radiographic factors that were associated with the selection of either L3 or L4 as LIV in posteriorly treated AIS patients with large lumbar curve. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.005DOI Listing

Transvenous embolization of arteriovenous malformations.

Clin Neurol Neurosurg 2019 Mar 11;178:70-76. Epub 2018 Sep 11.

Department of Medicine, Inova Alexandria Hospital, Alexandria 22304, USA; Department of Urological Surgery, El Gomhoureya General Hospital, Alexandria, Egypt.

Embolization of arteriovenous malformations is characteristically used as part of a multimodal treatment approach, pre-operatively to facilitate microsurgical resection or as a preradiosurgical adjunct. The concept of AVM cure via embolization alone has gained popularity in recent years. Embolization of AVMs has been most commonly performed transarterially, with the transvenous route traditionally eschewed given concern over precipitating premature venous occlusion and consequent hemorrhage. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.08.024DOI Listing

A comparative study of chronic subdural hematoma in three age ranges: Below 40 years, 41-79 years, and 80 years and older.

Clin Neurol Neurosurg 2019 Mar 29;178:63-69. Epub 2019 Jan 29.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Neurological Center, Ningxia People's Hospital, Ningxia, China. Electronic address:

Objective: To investigate clinical characteristics and outcomes of chronic subdural hematomas (CSDHs) in different age ranges.

Patients And Methods: A retrospective collection of data from CSDH patients ≤40 years, 41-79 years, and ≥80 years of age between August 2011 and May 2017 was performed. The differences and similarities of clinical data and outcomes among three groups were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193002
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http://dx.doi.org/10.1016/j.clineuro.2019.01.018DOI Listing
March 2019
6 Reads

Effect of thoracic kyphosis formation and rotational correction by direct vertebral rotation after the simultaneous double rod rotation technique for idiopathic scoliosis.

Clin Neurol Neurosurg 2019 Mar 28;178:56-62. Epub 2019 Jan 28.

Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, Japan.

Objective: The objective of the present study was to evaluate the effect of thoracic kyphosis formation and rotational correction by direct vertebral rotation (DVR) after the simultaneous double-rod rotation technique (SDRRT) for idiopathic scoliosis (IS).

Patients And Methods: The present study included twelve patients with IS who received SDRRT (SDRRT group) and twelve patients with IS who received DVR after SDRRT (SDRRT + DVR group). We investigated the following parameters preoperatively, postoperatively, and at postoperative 2 years: Cobb angle (PT, MT, T/L, C7-CSVL, AVT, TK (T5-12), LL(L1-S1) RSH, the angle of rotation (RAsag), percent change of RAsag and SRS22 (at postoperative 2 years only). Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.014DOI Listing

Gamma knife surgery efficacy in controlling postoperative residual clival chordoma growth.

Clin Neurol Neurosurg 2019 Mar 25;178:51-55. Epub 2019 Jan 25.

Department of Neurosurgery and Gamma Knife Center, International Medical Center (IMC), 42km. Ismailia Desert Road, Cairo, Egypt. Electronic address:

Objective: This study primarily aims to evaluate the efficacy of gamma knife surgery in controlling growth progression rate of residual clival chordoma through retrospective outcome analysis of 12 consecutive patients.

Patients And Methods: Data for 12 consecutive patients underwent GKS for post-operative residual histologically verified clival chordoma at our institution (IMC - Cairo- Egypt) from 2006 through end of 2017 were retrospectively reviewed and analyzed with mean follow-up period of 45 months (range12-120 months).

Results: In the last follow up MR, tumor growth control was achieved in 33. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.017DOI Listing
March 2019
1.248 Impact Factor

The correlation between phosphorylated Histone H3 (PHH3) and p-STAT3 in Meningiomas.

Clin Neurol Neurosurg 2019 Mar 25;178:46-50. Epub 2019 Jan 25.

Neurosurgery Department, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Objective: To assess the correlation between PHH-3 and STAT-3 in grade I and grade II meningiomas.

Patients And Methods: Medical records were retrospectively reviewed for all cranial cases which diagnosed and underwent surgery at Bezmialem Vakif University Hospital between 2012 and 2017. All cranial grade I and grade II meningioma patients constituted the core sample for this study. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.016DOI Listing

CT-guided percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective clinical study of 117 cases.

Clin Neurol Neurosurg 2019 Mar 21;178:42-45. Epub 2019 Jan 21.

Department of Pain Management, Xuanwu Hospital, Capital Medical University, Xicheng Zone, Beijing, 100053, China. Electronic address:

Objective: Glossopharyngeal neuralgia (GPN) is a rare disorder of the ninth cranial nerve. Percutaneous radiofrequency thermocoagulation (PRT) is an established treatment for neuropathic pain. Since PRT was first applied with GPN, only a few studies have provided detailed reports on its clinical outcomes and complications, and the number of cases was small. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.013DOI Listing
March 2019
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Corrected white blood cell count, cell index, and validation of a clinical model for the diagnosis of health care-associated ventriculitis and meningitis in adults with intracranial hemorrhage.

Clin Neurol Neurosurg 2019 Mar 21;178:36-41. Epub 2019 Jan 21.

Department of Internal Medicine, UT Health McGovern Medical School, Houston, TX, United States. Electronic address:

Objectives: To evaluate the utility of the corrected CSF white blood cell (WBC) count, cell index, CSF lactate, CSF glucose and a newly developed diagnostic model for the diagnosis of healthcare-associated ventriculitis or meningitis (HCAVM) in the setting of intracranial hemorrhage (ICH).

Patients And Methods: A case-control study of 111 adult patients with ICH with HCAVM (cases) or without HCAVM (controls) matched 1:2 by age, Glasgow Coma Scale (GCS), and Acute Physiology and Chronic Health Evaluation II (APACHE II) score enrolled in a large tertiary care center from 2003 to 2016.

Results: Subjects were appropriately matched by age, GCS, and APACHE II score (P > 0. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.012DOI Listing
March 2019
2 Reads

Experiences of an outpatient infusion center with intravenous magnesium therapy for status migrainosus.

Clin Neurol Neurosurg 2019 Mar 21;178:31-35. Epub 2019 Jan 21.

Department of Neurology, USC Keck School of Medicine, Los Angeles, USA. Electronic address:

Objectives: Exploratory study to investigate the effectiveness of intravenous magnesium as an abortive for status migrainosus in an outpatient infusion center, and characterize the patients who benefit from the therapy.

Patients & Methods: Retrospective analysis of 234 migraine patients who received IV magnesium as a headache abortive, at the headache clinic of University of Southern California. Additional intramuscular (IM) injections for nausea (prochlorperazine, odansetron, metoclopramide) or for refractory pain (ketorolac, dexamethasone, sumatriptan, dihydroergotamine), were administered as necessary. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.007DOI Listing
March 2019
1 Read

Spinal angiolipomas in pregnancy: Natural history and surgical treatment.

Clin Neurol Neurosurg 2019 Mar 21;178:25-30. Epub 2019 Jan 21.

Department of Clinical Neurosciences, Service of Neurosurgery, Lausanne University, Hospital (CHUV), Switzerland; Faculty of Biology and Medicine, University of Lausanne (UniL), Lausanne, Switzerland.

Spinal angiolipomas (SALs) are rare extradural tumors frequently located at the level of the thoracic spine and they are associated with spinal cord compromise that might result in severe myelopathy. While the first macroscopic description dates 1890, histologically these tumors where not described as angiolipomas until 1986 by Haddad et al. Occurrence in pregnancy is even more infrequent. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.015DOI Listing
March 2019
3 Reads
1.248 Impact Factor

The combination of warfarin use and the spot sign leads to detrimental outcomes in patients with intracerebral hematomas.

Clin Neurol Neurosurg 2019 Mar 17;178:20-24. Epub 2019 Jan 17.

Department of Neurosurgery, Tokai University, Kanagawa, Japan.

Objectives: While warfarin use and the presence of the spot sign on computed tomography angiography are associated with a high frequency of hematoma enlargement and high mortality among patients with intracerebral hematomas (ICHs), the effects of various combinations of warfarin use and/or the spot sign have never been clarified. The combinations of both or either of warfarin use and/or the spot sign were used to investigate their relationships with hematoma enlargement and mortality before the introduction of prothrombin complex concentrate (PCC) treatment.

Patients And Methods: Consecutive patients with ICHs admitted within 6 h of onset from 2009 to 2017 were investigated. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.011DOI Listing

Recovered bone flap tilting after encephalo-myo-synangiosis: A complication.

Clin Neurol Neurosurg 2019 Mar 17;178:13-19. Epub 2019 Jan 17.

Department of Neurosurgery, Second Affiliated Hospital, School of ⁎Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China. Electronic address:

Objectives: The aim of this study was to analyze the clinical data concerning the loosening and tilting of the recovered bone flap after encephalo-myo-synangiosis (EMS) and explore the potential underlying mechanisms.

Patients And Methods: Clinical data of all patients who underwent an EMS procedure from January 1, 2014 to April 30, 2018 at our hospital were collected. The cases with postoperative tilting of the recovered bone flap were identified and the clinical characteristics of the patients involved were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193000
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http://dx.doi.org/10.1016/j.clineuro.2019.01.009DOI Listing
March 2019
3 Reads

What happens to temporal hypometabolism contralateral to side of surgery in patients with bilateral temporal hypometabolism?

Clin Neurol Neurosurg 2019 Mar 17;178:7-12. Epub 2019 Jan 17.

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address:

Objective: To see what happens on PET hypometabolism on the temporal lobe contralateral to the side of surgery in patients with bitemporal hypometabolism (BTH).

Patients And Methods: This retrospective study with prospectively defined data evaluated the pre- and post-surgical PET hypometabolism on the contralateral temporal lobe after resection of ipsilateral temporal lobe in 10 patients with BTH operated between January, 2010 and May, 2018. On PET we compared standard uptake values (SUV) and relative metabolic activities as compared to normal subjects by means of Z-scores of hypometabolism of unresected temporal lobes before and after surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193001
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http://dx.doi.org/10.1016/j.clineuro.2019.01.008DOI Listing
March 2019
5 Reads

The relationship between preoperative factors and the presence of intramedullary increased signal intensity on T2-weighted magnetic resonance imaging in patients with cervical spondylotic myelopathy.

Clin Neurol Neurosurg 2019 Mar 14;178:1-6. Epub 2019 Jan 14.

Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Objective: To investigate preoperative factors affecting the presence of intramedullary increased signal intensity (ISI) on T2-weighted magnetic resonance imaging (MRI) in patients with cervical spondylotic myelopathy (CSM) and the impact of ISI on clinical manifestations.

Patients And Methods: Eighty-nine patients with CSM were retrospectively reviewed from January 2013 to December 2016 in our hospital. Based on the presence or absence of ISI on axial and sagittal T2-weighted MRI, patients were divided into ISI group (48 cases) and non-ISI group (41 cases). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193000
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http://dx.doi.org/10.1016/j.clineuro.2019.01.006DOI Listing
March 2019
8 Reads

Anti-N-methyl-d-aspartate receptor encephalitis in a patient with colon cancer.

Clin Neurol Neurosurg 2019 Feb 7;177:114-116. Epub 2019 Jan 7.

Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2019.01.002DOI Listing
February 2019
2 Reads

Spinal fractures incurred by a fall from standing height.

Clin Neurol Neurosurg 2019 Feb 7;177:106-113. Epub 2019 Jan 7.

Department of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, United Kingdom; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, United Kingdom. Electronic address:

Objective: Falls from standing are common, particularly amongst the aging population, due to declining mobility, proprioception and vision. They are often complicated by fragility fractures, including vertebral fractures, that are associated with significant morbidity and may represent a pre-terminal condition with high one-year mortality rates.

Patients And Methods: A retrospective review of the Trauma Audit and Research Network database for a major trauma centre was conducted for all patients admitted between January 2011 and December 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193000
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http://dx.doi.org/10.1016/j.clineuro.2019.01.005DOI Listing
February 2019
7 Reads

The effect of retinyl-palmitate on the level of pro and anti-inflammatory cytokines in multiple sclerosis patients: A randomized double blind clinical trial.

Clin Neurol Neurosurg 2019 Feb 7;177:101-105. Epub 2019 Jan 7.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Multiple sclerosis (MS) is an inflammatory and autoimmune disease associated with the imbalance of cytokines secreted from CD4 T cells. Studies have shown that vitamin A and its active derivatives are able to modulate the immune system in MS patients. The aim of the present study was to investigate the effect of supplementation of retinyl palmitate (RP), the dietary form of vitamin A, on pro- and anti-inflammatory cytokines in the plasma and supernatants of cultured peripheral blood mononuclear cells (PBMCs) of MS patients. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.003DOI Listing
February 2019
2 Reads
1.248 Impact Factor

Trends of postoperative length of stay in spine surgery over 10 years in Japan based on a prospective multicenter database.

Clin Neurol Neurosurg 2019 Feb 29;177:97-100. Epub 2018 Dec 29.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan. Electronic address:

Objectives: To identify factors associated with prolonged length of stay (LOS) in spine surgery, with the goal of establishing details of LOS for multiple diseases and surgical procedures.

Patients And Methods: The subjects were patients who underwent spine surgery at 10 facilities in the Nagoya Spine Group from January 2005 to December 2015. Data were collected for patient background, primary spinal pathology, anatomical location of the lesion, and surgical methods. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.020DOI Listing
February 2019
1 Read

Ataxia with novel compound heterozygous PEX10 mutations and a literature review of PEX10-related peroxisome biogenesis disorders.

Clin Neurol Neurosurg 2019 Feb 7;177:92-96. Epub 2019 Jan 7.

Department of Neurology and Institute of Neurology, Rui Jin Hospital & Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, 200025, China. Electronic address:

Objectives: To describe the clinical and genetic features of a Chinese peroxisome biogenesis disorder 6B patient with PEX10 mutations and review PEX10-related peroxisomal disorders.

Patients And Methods: The proband is a 7-year-old boy with mild mental retardation and gait instability, intention tremor and nystagmus. An extensive clinical and laboratory evaluation including molecular genetic studies was performed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.004DOI Listing
February 2019
2 Reads
1.248 Impact Factor

Computer-assisted virtual operation planning in anterior controllable anterior-displacement and fusion surgery for ossification of the posterior longitudinal ligament based on actual computed tomography data.

Clin Neurol Neurosurg 2019 Feb 29;177:86-91. Epub 2018 Dec 29.

Department of Orthopedic Surgery,Spine Center,Changzheng Hospital, Second Military Medical University No.415 Fengyang Road, Shanghai 200003,People's Republic of China. Electronic address:

Objectives: To investigate the effect of computer-assisted virtual operation planning (CAVOP) on anterior controllable anterior-displacement and fusion (ACAF) surgery for ossification of the posterior longitudinal ligament (OPLL).

Patients And Methods: A total of 25 patients with OPLL were enrolled in the study from September 2017 to December 2017. Preoperative Computed tomography (CT) scanning data were input into Mimics software to reconstruct three-dimensional (3D) models of actual cervical OPLL. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.019DOI Listing
February 2019
2 Reads

Medroxyprogesterone effects on colony growth, autophagy and mitochondria of C6 glioma cells are augmented with tibolone and temozolomide: Cell kinetic and electron microscopical studies with a broad review of the literature.

Clin Neurol Neurosurg 2019 Feb 31;177:77-85. Epub 2018 Dec 31.

Department of Biochemistry, Acibadem University, Istanbul, Turkey. Electronic address:

Objective: Risk of high grade gliomas is lower in young females and its incidence enhances after menopause suggesting likely protective roles of female hormones. Hormone replacement therapy (HRT) was widely employed to treat osteoporosis and some epidemiological studies showed that HRT regimes including progesterone analogs such as medroxyprogesterone acetate (MPA) decreased risk of glial tumors. Tibolone is a unique progesterone analog employed in HRT with tissue specific estrogenic effects and stimulates gene expressions very similar to those induced by MPA. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.022DOI Listing
February 2019
2 Reads

Clocking tinnitus: An audiology symptom of migraine.

Clin Neurol Neurosurg 2019 Feb 2;177:73-76. Epub 2019 Jan 2.

Department of Clinical Forensic Medicine, Kaohsiung Medical University Hospital, and College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan. Electronic address:

Objectives: In contrast to previous concept that tinnitus is confined to an otologic disorder, current evidence supports it as a phantom sensory phenomenon of vestibulocochlear damage with cortical reorganization. It is a common problem worldwide, but the treatment response is always unsatisfactory.

Patients And Methods: In this study, we report 10 patients who described their staccato tinnitus as simulating the ticking sound of a pendulum or quartz clock (or termed clocking tinnitus). Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.01.001DOI Listing
February 2019
1 Read

Smell status in functional movement disorders: New clues for diagnosis and underlying mechanisms.

Clin Neurol Neurosurg 2019 Feb 2;177:68-72. Epub 2019 Jan 2.

Smell and Taste Center, Department Department of Otorhinolaryngology- Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Functional movement disorders (FMDs) mimic a range of movements, neuropsychiatric and neurodegenerative disorders known to have smell dysfunction, which has been neglected in terms of its application to FMD. We aim to determine the smell status in FMD patients tested by a non-invasive, reliable and validated olfactory test.

Patients And Methods: We quantitatively assessed in thirty-five FMD patients their smell status and compared it to that of healthy age- and sex-matched controls, and of patients with Parkinson's disease (PD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183048
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http://dx.doi.org/10.1016/j.clineuro.2018.12.017DOI Listing
February 2019
2 Reads

Allergy may confer better survival on patients with gliomas.

Clin Neurol Neurosurg 2019 Feb 31;177:63-67. Epub 2018 Dec 31.

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, United States; Severn Health Solutions, Severna Park, MD, United States.

Objectives: Glioma susceptibility is inversely related to a history of allergies and atopy. Lung allergies are associated with 30% lower glioma susceptibility, compared to no lung allergies. Asthma and eczema also reduce the chance of glioma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183048
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http://dx.doi.org/10.1016/j.clineuro.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351160PMC
February 2019
8 Reads

Microsurgical treatment strategy for large and giant aneurysms of the internal carotid artery.

Clin Neurol Neurosurg 2019 Feb 17;177:54-62. Epub 2018 Dec 17.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: We aimed to summarize our microsurgical treatment results for large (10-25 mm) and giant (≥25 mm) intradural internal carotid artery (ICA) aneurysms over a 7-year period at a single institution and to describe our detailed strategy.

Patients And Methods: We reviewed the records of 68 patients with 69 aneurysms, including large and giant intradural ICA aneurysms, treated using microsurgical techniques from January 2008 to December 2014. We used adenosine-induced cardiac standstill or retrograde suction decompression for some aneurysm clipping cases and performed bypass surgery if needed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.014DOI Listing
February 2019
1 Read

Genetic influences on white matter and metabolism abnormal change in Alzheimer's disease: Meta-analysis for neuroimaging research on presenilin 1 mutation.

Clin Neurol Neurosurg 2019 Feb 26;177:47-53. Epub 2018 Dec 26.

Key Laboratory of Developmental Genes and Human Diseases, Department of Histology Embryology, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.

Mutations in the presenilin1 (PSEN1) cause familial Alzheimer's disease (FAD), providing a special opportunity to study pre-symptomatic individuals who would be predicted to develop Alzheimer's disease (AD) in the future. However, whether presenilin1 (PSEN1) genotype and neuroimaging markers is a harbinger of AD remains controversial. We aimed to explore the association of PSEN1 genotype with neuroimaging markers of AD: white matter integrity, cerebral amyloid deposition and brain metabolism. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.016DOI Listing
February 2019
1 Read

Clinical and radiological outcomes following surgical treatment for intra-cranial arachnoid cysts.

Clin Neurol Neurosurg 2019 Feb 27;177:42-46. Epub 2018 Dec 27.

Department of Neurosurgery, Wessex Neurological Centre, Southampton General Hospital, Southampton, UK.

Objectives: Intra-cranial arachnoid cysts are benign lesions which are usually incidental, however can produce neurological symptoms due to mass effect as they enlarge. Controversy still exists regarding the optimal option for the surgical management of these cysts. These options are neuroendoscopic fenestrations, microsurgical fenestrations +/- marsupialisation and insertion of a cysto-peritoneal shunt. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.018DOI Listing
February 2019
1 Read

Swallowing in Parkinson's disease: How is it affected?

Clin Neurol Neurosurg 2019 Feb 24;177:37-41. Epub 2018 Dec 24.

University of Health Sciences, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.

Objectives: The aim of this study was to evaluate the swallowing in patients with Parkinson's disease (PD) using comprehensive and multimodal methods.

Patients And Methods: The present study was conducted on 120 patients and 60 controls between January 2017 and January 2018. All participants' demographic data were recorded, and the swallowing of the subjects was evaluated by using several methods, including clinic, electrophysiologic, endoscopic and ultrasonographic procedure. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.015DOI Listing
February 2019
11 Reads

Impact of obesity on outcomes following lumbar spine surgery: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2019 Feb 17;177:27-36. Epub 2018 Dec 17.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

The influence of obesity on spine surgery outcomes is highly controversial with a current clinical equipoise. Several studies suggest higher perioperative morbidity with obesity while other studies suggest otherwise. To address this gap in the literature, we conducted a systematic review and meta-analysis in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines with the objective of better defining the impact of obesity on outcomes following lumbar spine surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183046
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http://dx.doi.org/10.1016/j.clineuro.2018.12.012DOI Listing
February 2019
7 Reads

Updated incidence of neurological deficits following insular glioma resection: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2019 Feb 17;177:20-26. Epub 2018 Dec 17.

Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

The resection of insular gliomas remains a neurosurgical challenge due to the close proximity of functionally-important cortical, white matter tracts, and vasculature structures. More recently, the feasibility of resection has gained traction, however, there is a lack of consolidated neurological deficit metrics. Thus, the aim of this study was to determine the incidences of neurological deficits following insular glioma resection to better guide selection algorithms and resource allocations. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.013DOI Listing
February 2019
1 Read

Intraoperative clinical application of augmented reality in neurosurgery: A systematic review.

Clin Neurol Neurosurg 2019 Feb 23;177:6-11. Epub 2018 Nov 23.

International Neuromodulation Center NEMOD, Bucaramanga, Colombia; Departamento de neurocirugía, división neurocirugía funcional, Clínica FOSCAL, Bucaramanga, Colombia; Universidad Autónoma de Bucaramanga, Colombia. Electronic address:

The interest and potential use of augmented reality (AR) in several medical fields since the early 90's has increased consistently. It provides intraoperative guidance for surgical procedures by rendering visible what cannot be seen directly, possibly affecting surgical outcomes. Our objective was to conduct a systematic review of the intraoperative clinical application of augmented reality in neurosurgery, in studies published during the last five years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183045
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http://dx.doi.org/10.1016/j.clineuro.2018.11.018DOI Listing
February 2019
10 Reads

Primary intradural Ewing's sarcoma of the spine: a systematic review of the literature.

Clin Neurol Neurosurg 2019 Feb 14;177:12-19. Epub 2018 Dec 14.

Mayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

The incidence of extraosseous Ewing's sarcoma, a highly malignant mesenchymal mass, is rare in the spinal cord and its clinical outcomes unknown. To date, few cases of primary intradural extramedullary Ewing's sarcoma (PIEES) have been reported, with varying follow-up. Herein, we aimed to perform a comprehensive review of all cases published in the literature and update previously reported cases from our institution. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.011DOI Listing
February 2019
2 Reads

MR T2 image classification in adult patients of cervical spinal cord injury without radiographic abnormality: A predictor of surgical outcome.

Clin Neurol Neurosurg 2019 Feb 14;177:1-5. Epub 2018 Dec 14.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Objectives: Although patients with cervical spinal cord injury without radiographic abnormality (SCIWORA) present increased signal intensity (ISI) on magnetic resonance imaging (MRI), its degree has not been examined. This study evaluated the clinical effectiveness of MRI-based ISI in adult patients of SCIWORA. Its predictive value for symptom severity was also evaluated. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.010DOI Listing
February 2019
1 Read

Hemopatch as a new dural sealant: A clinical observation.

Clin Neurol Neurosurg 2019 Jan 11;176:133-137. Epub 2018 Dec 11.

Department of Neurosurgery, United States.

Objectives: We analyzed our results using Hemopatch as a new dural sealant after durotomy in cranial and spinal neurosurgical procedures.

Patients And Methods: In our prospective single center study, we analyzed all patients who received Hemopatch used as a dural sealant between October 2016 and May 2017. 34 patients received Hemopatch used as a dural sealant in the study period. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.009DOI Listing
January 2019
4 Reads

Effects of the physician payments sunshine act on the patient experience and perception of care amongst neurosurgeons: A comparative study of online PRW ratings and industry payments.

Clin Neurol Neurosurg 2019 Jan 11;176:127-132. Epub 2018 Dec 11.

Northwestern University Department of Neurosurgery, Feinberg School of Medicine, 676 North St. Clair Street, NMH/Arkes Family Pavilion Suite 2210, Chicago, IL, 60611, United States. Electronic address:

Objective: Growing relationships between industry related financial payments and physicians have become an increasingly controversial topic as they relate to clinical judgment and patient care. Our objective is to analyze and quantify the effects of physician reported industry payments on the patient experience and patient satisfaction as defined by Physician Rating Websites (PRW).

Patients And Methods: We analyzed physician-reported industry payments received by neurosurgeons over four consecutive years as defined by the Physician Payments Sunshine Act (PPSA). Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.008DOI Listing
January 2019
3 Reads

Current management of pediatric chiari type 1 malformations.

Clin Neurol Neurosurg 2019 Jan 10;176:122-126. Epub 2018 Dec 10.

Department of Neurosurgery, Albany Medical College, Albany, NY, USA.

Objectives: Pediatric Chiari Type 1 Malformations (CM1) are commonly referred for neurosurgical opinion. The ideal management in children regarding surgical and radiographic decision making is not clearly delineated.

Patients And Methods: We retrospectively reviewed our cohort of patients age 18 years and younger referred to a single neurosurgeon for CM1. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.007DOI Listing
January 2019
3 Reads

The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial.

Clin Neurol Neurosurg 2019 Jan 8;176:116-121. Epub 2018 Dec 8.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. Electronic address:

Objective: This study was conducted to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in subjects with Parkinson's disease (PD).

Patients And Methods: This randomized, double-blind, placebo-controlled clinical trial was performed in 40 subjects with PD. Participants were randomly allocated into two groups to take either 1000 mg/day of omega-3 fatty acids from flaxseed oil plus 400 IU/day of vitamin E supplements or placebo (n = 20 each group) for 12 weeks. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.006DOI Listing
January 2019
16 Reads
1.248 Impact Factor

Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy.

Clin Neurol Neurosurg 2019 Jan 29;176:110-115. Epub 2018 Nov 29.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.

Objective: To evaluate the clinical and histopathological features of elderly patients with subcortical intracerebral hemorrhage (ICH), and to analyze the presence of cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD) type pathologic changes using amyloid beta (Aβ) and tau immunohistochemistry.

Patients And Methods: We retrospectively analyzed cases satisfying the Boston criteria for CAA among patients with subcortical hemorrhage who underwent surgical removal by craniotomy at our hospital. Surgical specimens were subjected to hematoxylin and eosin (HE) staining as well as immunostaining. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.11.020DOI Listing
January 2019
2 Reads

Prognostic role of microRNA-155 expression in gliomas: A meta-analysis.

Clin Neurol Neurosurg 2019 Jan 7;176:103-109. Epub 2018 Dec 7.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Recent studies have reported that microRNA-155 (miR-155) is linked to the clinical outcomes of many tumors. However, its role in prognosis of gliomas remains unclear. This meta-analysis aims to evaluate the prognostic value of miR-155 in the survival of patients with gliomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183046
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http://dx.doi.org/10.1016/j.clineuro.2018.12.005DOI Listing
January 2019
10 Reads

Ventilation/perfusion SPECT/CT in patients with severe and rigid scoliosis: An evaluation by relationship to spinal deformity and lung function.

Clin Neurol Neurosurg 2019 Jan 6;176:97-102. Epub 2018 Dec 6.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:

Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.12.003DOI Listing
January 2019
3 Reads

Molecular alterations in meningiomas: Literature review.

Clin Neurol Neurosurg 2019 Jan 7;176:89-96. Epub 2018 Dec 7.

Departament of Neurology, Laboratory of Molecular and Cellular Biology, LIM15, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.

Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183046
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http://dx.doi.org/10.1016/j.clineuro.2018.12.004DOI Listing
January 2019
16 Reads