6,891 results match your criteria Clinical Nephrology[Journal]


Burden, access, and disparities in kidney disease.

Clin Nephrol 2019 Feb 1. Epub 2019 Feb 1.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.5414/CN91WKDEDIDOI Listing
February 2019

The importance of correct estimation of renal function for drug treatment in hospitalized elderly patients, especially women: A prospective observational study
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Clin Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Aim: To compare renal function by several GFR formulas (particularly cystatin C eGFR-"CAPA") in relation to renal risk drugs (RRDs) in patients admitted to two geriatric wards in a university geriatric department.

Materials And Methods: This was a prospective quality improvement study including 108 patients, 2/3 women, age ≥ 75 years, admitted with multimorbidity. Renal function tests were performed with Cockcroft & Gault with uncalibrated (C&Guc) and calibrated creatinine (C&Gcc), and 3 - 4 points' iohexol clearance (mGFR) in mL/min, and eGFR with MDRD4, CKD-EPI, CAPA, and BIS2 clearance in mL/min/1. Read More

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http://dx.doi.org/10.5414/CN109536DOI Listing
January 2019

Impaired cognition in hemodialysis patients: The Montreal Cognitive Assessment (MoCA) and important clues for testing
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Clin Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Background: Cognitive impairment is common among hemodialysis (HD) patients and is associated with poor treatment compliance and mortality. The aim of this study is to evaluate relatively young HD patients with less comorbidities using the Montreal Cognitive Assessment (MoCA) and identify clues for earlier detection of cognitive impairment with the help of cognitive subscale scores.

Materials And Methods: A total of 103 chronic HD patients (mean age 48. Read More

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http://dx.doi.org/10.5414/CN109506DOI Listing
January 2019

Maintenance therapy for lupus nephritis with mycophenolate mofetil or azathioprine. A meta-analysis
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Clin Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Aim: Maintenance therapy for lupus nephritis (LN) remains controversial. This meta-analysis of randomized controlled trials (RCTs) describes the comparative benefits and safety of mycophenolate mofetil (MMF) versus azathioprine (AZA) as maintenance therapy in patients with LN.

Materials And Methods: RCTs that compared the maintenance regimens of MMF and AZA in the treatment of LN were included. Read More

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http://dx.doi.org/10.5414/CN109450DOI Listing
January 2019
1 Read

Changes in primary glomerulonephritis in Singapore over four decades
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Clin Nephrol 2019 Jan 21. Epub 2019 Jan 21.

This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1 decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2 decade, the percentage of mesangial proliferative GN decreased, but membranous GN became more common, as was seen in China and Thailand. Read More

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http://dx.doi.org/10.5414/CN109577DOI Listing
January 2019
8 Reads

Patients' perspectives on dialysis decision-making and end-of-life care
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Clin Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Background: Few studies have explored dialysis patients' perspectives on dialysis decision-making and end-of-life-care (EoLC) preferences. We surveyed a racially diverse cohort of maintenance dialysis patients in the Cleveland, OH, USA, metropolitan area.

Materials And Methods: In this cross-sectional study, we administered a 41-item questionnaire to 450 adult chronic dialysis patients. Read More

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http://dx.doi.org/10.5414/CN109608DOI Listing
January 2019
1 Read

Risk factors affecting arteriovenous access patency in nocturnal home hemodialysis patients
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Clin Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Background And Aims: Intensive hemodialysis is associated with more frequent arteriovenous (AV) access complications. We performed a retrospective cohort study to ascertain potential risk factors associated with access dysfunction in a cohort of nocturnal home hemodialysis (HHD) patients.

Material And Methods: Consecutive patients undergoing HHD from October 1999 to November 2015 using an AV access were included. Read More

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http://dx.doi.org/10.5414/CN109572DOI Listing
January 2019
3 Reads

Telavancin-associated acute kidney injury
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Clin Nephrol 2019 Jan 7. Epub 2019 Jan 7.

Telavancin is a lipoglycopeptide semi-synthetic derivative of vancomycin used for select infections caused by Gram-positive bacteria including . Human clinical trials suggest that telavancin is potentially nephrotoxic, however there is no histopathologic description of acute kidney injury (AKI) in humans. An animal model has recently characterized the histologic changes associated with telavancin-induced AKI as proximal tubular injury with numerous phagolysosomes. Read More

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http://dx.doi.org/10.5414/CN109651DOI Listing
January 2019
2 Reads

The clinical and pathological features of adefovir dipivoxil-related renal impairment
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Clin Nephrol 2019 Jan 7. Epub 2019 Jan 7.

Aims: To investigate the clinicopathological features and outcomes of adefovir dipivoxil (ADV)-related renal impairment in Chinese patients.

Materials And Methods: Clinical, pathological, and follow-up data from 15 patients with ADV-related renal impairment were studied. Proximal renal tubular dysfunction (PRTD) was defined by the presence of at least two of the following four abnormalities: hypophosphatemia, hypouricemia, nondiabetic glucosuria, and proteinuria. Read More

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http://dx.doi.org/10.5414/CN109574DOI Listing
January 2019
3 Reads
1.232 Impact Factor

Treatment of iron deficiency in patients with chronic kidney disease: A prospective observational study of iron isomaltoside (NIMO Scandinavia)
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Clin Nephrol 2019 01 7. Epub 2019 Jan 7.

Aims: Iron deficiency is common in patients with chronic kidney disease (CKD). Appropriate iron substitution is critical and intravenous iron is an established therapy for these patients. The objective of this study was to assess treatment routine, -effectiveness, and safety of iron isomaltoside (Monofer®, Pharma-cosmos A/S, Holbaek, Denmark) in CKD patients in clinical practice. Read More

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http://dx.doi.org/10.5414/CN109474DOI Listing
January 2019
2 Reads

Nephrotic state substantially enhances apparent mycophenolic acid clearance
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Clin Nephrol 2018 Dec 21. Epub 2018 Dec 21.

Background: Several factors may decrease plasma protein binding of mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), and potentially enhance its clearance. It is unclear if MMF dose adjustments are required for the treatment of steroid-resistant nephrotic syndrome (SRNS). Therapeutic drug monitoring of MPA levels is not widely utilized in the treatment of steroid-resistant nephrotic syndrome (SRNS). Read More

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http://dx.doi.org/10.5414/CN109583DOI Listing
December 2018
2 Reads
1.232 Impact Factor

A case of nephrotic syndrome showing contemporary presence of apolipoprotein E2 homozygote glomerulopathy and membranous nephropathy-like findings modified by apolipoprotein E Toyonaka.

Clin Nephrol Case Stud 2018 30;6:45-51. Epub 2018 Nov 30.

Division of Nephrology, Kansai Electric Power Hospital.

A 79-year-old man was admitted to our hospital for proteinuria due to nephrotic syndrome. Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus. In addition, electron microscopic findings (EM) revealed peculiar electron-dense deposits (EDDs) in both sides of the glomerular basement membrane. Read More

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http://dx.doi.org/10.5414/CNCS109509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287602PMC
November 2018
2 Reads

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
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Clin Nephrol 2019 Feb;91(2):107-113

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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http://dx.doi.org/10.5414/CN109520DOI Listing
February 2019
2 Reads

Hemodynamic effects of hemodialyzer pump speed on arteriovenous fistulas
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Clin Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Aim: Arteriovenous fistulas (AVF) are the optimal vascular access for hemodialysis although many fistulas fail. The impetus to increase hemodialyzer blood flow (QB) in order to maximize solute clearances may be counterbalanced if AVF suffer adverse hemodynamic effects from accelerated pump flows. The optimal QB to maintain adequate hemodialysis without potentially contributing to AVF dysfunction is unknown. Read More

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http://dx.doi.org/10.5414/CN109456DOI Listing
December 2018
2 Reads

Persian version of thirst distress scale (TDS) in patients on hemodialysis: Factor structure and psychometric properties
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Clin Nephrol 2019 Feb;91(2):72-78

Background: Patients on hemodialysis can experience thirst distress. However, there is no valid and reliable Persian instrument to measure this condition in such patients. The present study aims to determine the psychometric properties of the Persian version of the thirst distress scale (TDS) for patients on hemodialysis. Read More

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http://dx.doi.org/10.5414/CN109406DOI Listing
February 2019
1 Read

External validation of prediction models for mortality in an incident dialysis population
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Clin Nephrol 2019 Feb;91(2):65-71

Aims: Different prediction models have been established to estimate mortality in the dialysis population. This study aims to externally validate the different available mortality prediction models in an incident dialysis population.

Materials: This was a retrospective cohort study of incident hemodialysis and peritoneal dialysis patients at two academic tertiary care centers. Read More

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http://dx.doi.org/10.5414/CN109310DOI Listing
February 2019
6 Reads
1.232 Impact Factor

A case of membranous nephropathy characterized by atypical distribution of phospholipase A2 receptor
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Clin Nephrol 2019 Feb;91(2):114-119

A 77-year-old man was referred to our hospital with persistent proteinuria and progressive lower leg edema. Past history was unremarkable except for hypertension. Autoimmune diseases, infections, and malignancies were excluded based on clinical and laboratory test results. Read More

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http://dx.doi.org/10.5414/CN109567DOI Listing
February 2019
7 Reads

Risk factors for graft loss in kidney transplant recipients with g3 glomerulitis: A single-center experience
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Clin Nephrol 2019 Feb;91(2):95-100

Background: Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined.

Materials And Methods: We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study.

Results: The diagnosis of g3 glomerulonephritis was made 6. Read More

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http://dx.doi.org/10.5414/CN109484DOI Listing
February 2019
11 Reads

Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy
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Clin Nephrol 2019 Feb;91(2):79-86

Introduction: C3 glomerulonephritis (C3GN) is a form of proliferative glomerulonephritis characterized by dominant glomerular C3 deposition. There is currently no consensus guideline on therapy for this disease. Experience with corticosteroids alone is scant in C3GN. Read More

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http://dx.doi.org/10.5414/CN109442DOI Listing
February 2019
2 Reads

Management of Denys-Drash syndrome: A case series based on an international survey.

Clin Nephrol Case Stud 2018 12;6:36-44. Epub 2018 Nov 12.

Department of Pediatrics and Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Denys-Drash syndrome (DDS), a condition caused by mutations in the tumor-suppressor gene WT-1, is associated with a triad of disorders: ambiguous genitalia, nephrotic syndrome leading to end-stage renal disease (ESRD), and Wilms' tumor. Given the variable disease course, management is challenging. We aimed to describe the evolution of DDS and the range of management strategies by summarizing the clinical courses of cases collected from a questionnaire sent to the international pediatric nephrology community. Read More

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https://www.dustri.com/article_response_page.html?artId=1776
Publisher Site
http://dx.doi.org/10.5414/CNCS109515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236398PMC
November 2018
12 Reads

Peritoneal vasculopathy in the pathophysiology of long-term ultrafiltration failure: A hypothesis based on clinical observations
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Clin Nephrol 2019 Jan;91(1):1-8

Ultrafiltration failure in long-term peritoneal dialysis patients is a well-known and important, but poorly-explained complication of the treatment. Transcapillary ultrafiltration consists mainly of small-pore fluid transport and partly of free-water transport. The former is to a large extent dependent on the hydrostatic pressure gradient and on the number of perfused peritoneal microvessels. Read More

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http://dx.doi.org/10.5414/CN109596DOI Listing
January 2019
6 Reads

Successful pregnancy in a patient with pulmonary renal syndrome double-positive for anti-GBM antibodies and p-ANCA
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Clin Nephrol 2019 Feb;91(2):101-106

Background: Antiglomerular basement membrane (anti-GBM) antibody disease is a rare condition causing pulmonary hemorrhage and necrotizing glomerulonephritis (pulmonary renal syndrome).

Case: We report a 30-year-old woman who presented with life-threatening pulmonary hemorrhage and an active urinary sediment, with normal glomerular filtration rate in the 13 week of pregnancy. Anti-GBM antibodies in serum were negative, but perinuclear antineutrophil cytoplasmatic antibodies (p-ANCA) were detected. Read More

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http://dx.doi.org/10.5414/CN109584DOI Listing
February 2019
6 Reads

Chronic systemic capillary leak syndrome treatment with intravenous immune globulin: Case report and review of the literature
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Clin Nephrol 2019 Jan;91(1):59-63

Systemic capillary leak syndrome (SCLS) is a disorder characterized by increased vascular permeability with intermittent acute episodes of profound capillary leak that may result in hypotension or shock. A rarely described chronic form of SCLS (cSCLS) presents as refractory edema, with pleural and/or pericardial effusions and hypoalbuminemia. These entities are differentiated by massive and periodic episodes of capillary leak, which can result in shock in SCLS, and chronic refractory edema in cSCLS. Read More

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http://dx.doi.org/10.5414/CN109467DOI Listing
January 2019
17 Reads

Immunoglobulin G subclass 3 in ISN/RPL lupus nephritis classification
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Clin Nephrol 2019 Jan;91(1):32-39

Objectives: In lupus nephritis, the immune complex plays a very important role in kidney disease progression, and immunoglobulin G subclass 3 (IgG3) may play an important role in endothelial damage as lupus nephropathy progresses. We evaluated the association between IgG3 positivity and lupus nephritis activity.

Materials And Methods: We identified 71 biopsies taken from 57 patients who had lupus nephritis with enough tissue to allow light and immunofluorescence microscopy. Read More

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http://dx.doi.org/10.5414/CN109459DOI Listing
January 2019
10 Reads

Treatment of recurrent, post-kidney transplant membranoproliferative glomerulonephritis with plasmapheresis and rituximab: A case report and literature review
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Clin Nephrol 2019 Jan;91(1):52-58

Membranoproliferative glomerulonephritis is known to recur after kidney transplantation and may lead to allograft loss. Although an optimal treatment has not been determined, B-cell targeted therapies are now increasingly used as first-line agents, based on growing data showing antibodies as key players in the pathogenesis of membranoproliferative glomerulonephritis. Here, we report a case of recurrent immune complex-mediated membranoproliferative glomerulonephritis 3 years after a living-donor kidney transplant. Read More

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http://dx.doi.org/10.5414/CN109451DOI Listing
January 2019
21 Reads

A simplified percutaneous technique for inserting Tenckhoff catheters for peritoneal dialysis.

Clin Nephrol 2019 Jan;91(1):17-24

Aim: Successful catheter implantation is highly essential for delivering effective peritoneal dialysis (PD). The aim of the present study was to describe a newly developed, minimally invasive percutaneous technique for providing safe, timely, and effective peritoneal catheter insertion and assess the long-term outcome.

Materials And Methods: 100 PD catheters were placed in 100 consecutive patients by a nephrologist using the modified percutaneous technique with a special trocar, from August 1, 2010 to December 31, 2011. Read More

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http://dx.doi.org/10.5414/CN109410DOI Listing
January 2019
24 Reads

Rate and risk factors for AKI after CT scans in a cancer cohort
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Clin Nephrol 2018 Nov 12. Epub 2018 Nov 12.

Aims: The proinflammatory milieu in cancer patients may expose them to increased risk for acute kidney injury (AKI) after IV contrast (CON). The aims of this study were to determine: (1) the rates of AKI after CON and noncontrast (NC) CT scans in cancer inpatients, (2) if rates differed among cancer subtypes, and (3) whether recent chemotherapy, comorbid conditions, or nephrotoxins increase AKI after CON.

Materials And Methods: Retrospective data was collected on adults who had received a CON or NC CT from January 1, 2012 to December 30, 2014. Read More

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http://dx.doi.org/10.5414/CN109591DOI Listing
November 2018
2 Reads

Acute esophageal necrosis (black esophagus) complicating calcific uremic arteriolopathy
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Clin Nephrol 2019 Jan;91(1):48-51

The current case report describes a chronic hemodialysis patient presenting with painful penile ulceration that was clinically and histologically proven to be related to calcific uremic arteriolopathy. The patient subsequently developed severe upper gastrointestinal bleeding that was both endoscopically and histologically shown to be due to acute esophageal necrosis (AEN), also known as necrotizing esophagitis and "black esophagus". AEN is a rare condition characterized by diffuse necrosis of the esophageal mucosa. Read More

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http://dx.doi.org/10.5414/CN109470DOI Listing
January 2019
13 Reads

Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature.

Clin Nephrol Case Stud 2018 26;6:31-35. Epub 2018 Oct 26.

Infectious Diseases Unit, Ospedale Policlinico San Martino, Genoa, Italy.

In this report, we describe the coexistence of two rare and debated complications of hepatitis C virus (HCV) infection: interstitial nephritis, with associated focal glomerulosclerosis, and autoimmune hepatitis, in a 55-year-old HIV/HCV-coinfected woman. The patient was treated for the immune-mediated manifestations with mycophenolate mofetil, which she continued for 9 years, as symptoms relapsed at every attempt to discontinue immunosuppression. The patient finally cleared HCV infection thanks to new direct-acting agents and could discontinue immunosuppressive therapy maintaining stable conditions and laboratory parameters after 24-weeks follow-up. Read More

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https://www.dustri.com/article_response_page.html?artId=1774
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http://dx.doi.org/10.5414/CNCS109221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218875PMC
October 2018
19 Reads

Effectiveness of antiplatelet drugs for the prevention of diabetic nephropathy: A meta-analysis of randomized controlled trials
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Clin Nephrol 2018 Dec;90(6):419-426

Aims: To evaluate the effects of antiplatelet drugs on proteinuria, renal function, and blood pressure (BP) in patients with diabetic nephropathy (DN).

Materials And Methods: A meta-analysis of randomized controlled trials (RCTs) was performed. Relevant RCTs were identified by a systematic search of the PubMed, Cochrane Library, and Embase databases. Read More

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http://dx.doi.org/10.5414/CN109588DOI Listing
December 2018
8 Reads

The incidence, predictors, and prognosis of acute kidney injury after transcatheter aortic valve implantation
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Clin Nephrol 2018 Dec;90(6):373-379

Introduction And Aims: Transcatheter aortic valve implantation (TAVI) is an alternative procedure for patients with symptomatic aortic stenosis unfit for open heart surgery. Notwithstanding the safer profile, TAVI can still result in serious complications including acute kidney injury (AKI).

Materials And Methods: We conducted a single-center retrospective study to investigate the incidence of AKI following TAVI, identify any predictors, and assess the impact on patient survival. Read More

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http://dx.doi.org/10.5414/CN109544DOI Listing
December 2018
2 Reads

Discontinuation of maintenance therapy in frequently relapsing nephrotic syndrome
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Clin Nephrol 2019 Jan;91(1):25-31

Childhood steroid-dependent (SDNS) and frequently relapsing (FRNS) nephrotic syndromes often require long-term immunosuppressive therapy to maintain remission. Successful discontinuation of maintenance therapy remains to be a challenge with these children. In the following article, we report our experience on patients after discontinuation of steroid-sparing immunosuppressive maintenance therapy (IT). Read More

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http://dx.doi.org/10.5414/CN109532DOI Listing
January 2019
2 Reads

The relationship between serum osteopontin and FGF 23 levels with valvular calcification in hemodialysis patients
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Clin Nephrol 2019 Jan;91(1):9-16

Backgrounds And Aims: Cardiovascular calcification is an important cause of morbidity and mortality in hemodialysis (HD) patients. Vascular and valvular calcification are indicators of increased tissue calcification. The relationship of osteopontin (OPN) - which is known as a vascular calcification inhibitor - and fibroblast growth factor-23 (FGF-23) - which its related to vascular calcification, as recently shown - to valvular calcification is unknown. Read More

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http://dx.doi.org/10.5414/CN109505DOI Listing
January 2019
1 Read

Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
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Clin Nephrol 2018 Dec;90(6):431-433

The etiology of pulmonary renal syndrome can be broadly divided into infectious and autoimmune (predominantly ANCA vasculitis). The importance of timely differentiating between them stems from the deleterious effects of their respective treatment if misdiagnosed. Serology and tissue evaluation by pathology are employed to aid in this, however, in rare cases, this can be difficult. Read More

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http://dx.doi.org/10.5414/CN109495DOI Listing
December 2018
13 Reads

Individual renal unit urine sampling to identify unilateral metabolic defects
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Clin Nephrol 2019 Feb;91(2):87-94

Aims: Preventing kidney stone recurrence relies on detecting and modifying urine chemistry abnormalities. The assumption is that an abnormality is due to a global metabolic defect present in both kidneys. However, we hypothesize that clinically significant unilateral defects may exist. Read More

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http://dx.doi.org/10.5414/CN109473DOI Listing
February 2019
8 Reads

Low prevalence of apolipoprotein L1 gene variants in Black South Africans with hypertension-attributed chronic kidney disease
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Clin Nephrol 2019 Jan;91(1):40-47

Variants in apolipoprotein L1 gene were shown to be associated with higher rates of nondiabetic kidney disease in black patients compared with white patients. Frequencies of these variants differ substantially in African populations, suggesting that their contribution to kidney disease might differ. We determined the frequency and association of risk alleles with markers of kidney disease in black South Africans with hypertension-attributed chronic kidney disease (CKD) and their first-degree relatives. Read More

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http://dx.doi.org/10.5414/CN109432
DOI Listing
January 2019
17 Reads

Cryptococcal meningitis in adult patients with primary nephrotic syndrome
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Clin Nephrol 2018 Dec;90(6):390-395

Background: Cryptococcal meningitis (CM) is a rare condition in patients with primary nephrotic syndrome (PNS). Here, we describe the clinical characteristics, possible risk factors, and outcomes of eleven patients with PNS and CM.

Materials And Methods: A systematic review of medical records from 11 patients with PNS and CM admitted to the First Affiliated Hospital of Wenzhou Medical University from April 2005 to April 2015 was performed. Read More

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http://dx.doi.org/10.5414/CN109384DOI Listing
December 2018
2 Reads

Relationships between abdominal aortic calcification, glomerular filtration rate, and cardiovascular risk factors in patients with non-dialysis dependent chronic kidney disease
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Clin Nephrol 2018 Dec;90(6):380-389

Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors.

Materials And Methods: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). Read More

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http://dx.doi.org/10.5414/CN109441DOI Listing
December 2018
1 Read

Disappearance of a thrombotic microangiopathy-like glomerular lesion in a patient with a placental site trophoblastic tumor after hysterectomy.

Clin Nephrol Case Stud 2018 20;6:27-30. Epub 2018 Sep 20.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, and.

A 32-year-old woman presented with amenorrhea after a normal childbirth and subsequently developed nephrotic syndrome. Renal biopsy showed a thrombotic microangiopathy (TMA)-like glomerular lesion with deposits of immunoglobulins, complements, and fibrinogen. Increased serum levels of the beta subunit of human chorionic gonadotropin, abnormal uterine findings from imaging studies, and endometrial biopsy findings suggested gestational trophoblastic disease. Read More

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http://dx.doi.org/10.5414/CNCS109440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159349PMC
September 2018
8 Reads

Community acute kidney injury is associated with short- and long-term adverse outcomes in patients admitted with acute myocardial infarction
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Clin Nephrol 2018 Dec;90(6):404-412

Aims: The influence of community acute kidney injury on patients with myocardial infarction has not been explored. The Veterans Affair electronic health system was analyzed to test the hypothesis that patients who have myocardial infarction complicated by community acute kidney injury have higher short- and long-term mortality and cardiovascular outcomes than those who do not suffer acute kidney injury.

Materials And Methods: Odd ratios were calculated for in-hospital mortality. Read More

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http://dx.doi.org/10.5414/CN109548DOI Listing
December 2018
7 Reads

Hepatitis E infection in solid organ transplant recipients: An overlooked diagnosis?
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Clin Nephrol 2018 Dec;90(6):427-430

Hepatitis E virus (HEV) is gaining recognition as an important but under-recognized pathogen, particularly in immunocompromised individuals. It should be considered as a potential differential diagnosis in such patients presenting with acute hepatitis. We report a case of a kidney-pancreas transplant recipient who developed acute liver dysfunction; this was found to be due to HEV infection acquired through consumption of undercooked pork. Read More

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http://dx.doi.org/10.5414/CN109533DOI Listing
December 2018
2 Reads