6,334 results match your criteria Clinical Microbiology and Infection[Journal]


Implications of identifying the recently defined members of the S. aureus complex, S. argenteus and S. schweitzeri: A position paper of members of the ESCMID Study Group for staphylococci and Staphylococcal Diseases (ESGS).

Clin Microbiol Infect 2019 Mar 11. Epub 2019 Mar 11.

Department of Clinical Microbiology, Hvidovre Hospital.

Background: Staphylococcus argenteus and Staphylococcus schweitzeri, previously known as divergent Staphylococcus aureus clonal lineages, have been recently established as novel, difficultly delimitable, coagulase-positive species within the S.aureus complex. Methicillin-resistant S. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.028DOI Listing

Towards precision dosing of vancomycin: A systematic evaluation of pharmacometric models for Bayesian forecasting.

Clin Microbiol Infect 2019 Mar 11. Epub 2019 Mar 11.

Dept. of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Germany. Electronic address:

Objectives: Vancomycin is a vital treatment option for patients suffering from critical infections, and therapeutic drug monitoring is recommended. Bayesian forecasting is reported to improve trough concentration monitoring for dose adjustment. However, the predictive performance of pharmacokinetic models that are utilized for Bayesian forecasting has not been systematically evaluated. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.029DOI Listing

Individual and community-level risk factors for ESBL Enterobacteriaceae colonization identified by universal admission screening in London.

Clin Microbiol Infect 2019 Mar 5. Epub 2019 Mar 5.

Centre for Clinical Infection and Diagnostics Research (CIDR), Department of Infectious Diseases, King's College London & Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Objectives: We evaluated risk factors for gastrointestinal carriage of ESBL-producing Enterobacteriaceae (ESBL-E) including individual-level variables such as antibiotic use and foreign travel, and community-level variables such as housing and deprivation.

Methods: All admissions to a London hospital group were approached to be screened for ESBL-E carriage using rectal swabs for four months in 2015 in an observational study. Patients completed a risk factor questionnaire. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.026DOI Listing
March 2019
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The association of adequate empiric treatment and time to recovery from bacteremic urinary tract infections: a retrospective cohort study.

Clin Microbiol Infect 2019 Mar 4. Epub 2019 Mar 4.

Division of Infectious Diseases and Clinical Epidemiology, Sunnybrook Health Sciences Centre, Toronto, Ontario Canada. Electronic address:

Objectives: To evaluate whether patients with bacteremic urinary tract infection (UTI) who receive inadequate empiric therapy have worse outcomes than those with adequate therapy.

Methods: Retrospective cohort study of patients with bacteremic UTI. The exposure variable was adequate versus inadequate empiric antibiotic therapy (AEAT vs IEAT) within 24 hours of culture collection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.027DOI Listing
March 2019
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Antibiotic Overconsumption and Resistance in Turkey.

Clin Microbiol Infect 2019 Mar 4. Epub 2019 Mar 4.

Infectious Diseases and Clinical Microbiology Department, Koç University School of Medicine, Ankara, Turkey. Electronic address:

In its latest Health Policy Studies report, OECD stated that the highest rates of antimicrobial resistance (around 35% in Turkey, Korea and Greece) were seven times higher than the lowest rates among its member countries in 2015. As the OECD country with the highest resistance (38.8%) despite a 15-year hospital antibiotic restriction programme, Turkey is in urgent need of revising its policies and drawing an effective action plan to reverse the current trend. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.024DOI Listing
March 2019
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Clinical relevance of preservation fluid contamination in solid organ transplantation: a call for mounting the evidence.

Clin Microbiol Infect 2019 Mar 4. Epub 2019 Mar 4.

Transplantation Center and Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Literature concerning preservation fluid contamination in solid organ transplantation is limited. Incidence of contamination is probably high, however its clinical implications are not well established and rates of true infection are probably low. Preemptive therapy of positive preservation fluid cultures is controversial. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.025DOI Listing
March 2019
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Spontaneous capsule loss in Haemophilus influenzae serotype b associated with Hib conjugate vaccine failure and invasive disease.

Clin Microbiol Infect 2019 Mar 26;25(3):390-391. Epub 2018 Oct 26.

Irish Meningitis and Sepsis Reference Laboratory, Temple Street Children's University Hospital, Dublin 1, Ireland; Department of Microbiology, Royal College of Surgeons, Ireland.

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http://dx.doi.org/10.1016/j.cmi.2018.10.011DOI Listing
March 2019
1 Read

Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency.

Clin Microbiol Infect 2019 Mar 25;25(3):384.e1-384.e3. Epub 2018 Oct 25.

Department of Medical Microbiology, Capital Medical University, Beijing, China; Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland. Electronic address:

Objectives: To evaluate the association of mannose-binding lectin (MBL) deficiency with susceptibility and clinical features of group B Streptococcus (GBS) causing meningitis in Chinese infants.

Methods: During 2014-2017, 33 infants with laboratory-confirmed GBS meningitis were included. Six polymorphisms (H/L, Y/X, P/Q, A/D, A/B and A/C) of MBL were sought for in these patients and in 330 healthy controls by PCR-based sequencing. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.10.003DOI Listing

Experiences of carriers of multidrug-resistant organisms: a systematic review.

Clin Microbiol Infect 2019 Mar 26;25(3):274-279. Epub 2018 Oct 26.

Scientific Center for Quality of Healthcare (IQ Healthcare), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: A comprehensive overview of the ways control measures directed at carriers of multidrug-resistant organisms (MDRO) affect daily life of carriers is lacking. In this systematic literature review, we sought to explore how carriers experience being a carrier and how they experience being subjected to control measures by looking at the impact on basic capabilities.

Methods: We searched Medline, Embase and PsychINFO until 26 May 2016 for studies addressing experiences of MDRO carriers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183071
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http://dx.doi.org/10.1016/j.cmi.2018.10.007DOI Listing
March 2019
2 Reads

Acquired resistance in fungi: how large is the problem.

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Infectious Diseases Unit, 3(rd) Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Thessaloniki, Greece.

To combat fungi that may harm the health of plants, animals and humans, a number of antifungal agents have been developed and used. Fungi may be primarily resistant to the antifungal drugs or may develop resistance after exposure to antifungals. Candida glabrata and other Candida spp. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.018DOI Listing
February 2019
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Dermacoccus nishinomiyaensis as a cause of persistent pediatric catheter-related bacteremia.

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Service de Bactériologie, Centre de Biologie Humaine, CHU Amiens-Picardie, France. Electronic address:

The authors herein report a persistent Dermacoccus nishinomiyaensis catheter- related bacteremia in a 1-year-old boy with severe Hirschsprung's disease. D. nishinomiyaensis isolates were identified by Matrix-Assisted Laser Desorption-Ionization Time-of-Light Mass Spectrometry (MALDI-TOF MS; Bruker Daltonics), confirmed by sequencing of the rrs gene encoding the 16rRNA. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.023DOI Listing
February 2019

Re: 'Chronic Q fever-related complications and mortality: data from a nationwide cohort' by Roeden et al.

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Aix-Marseille Univ, IRD, APHM, MEPHI, Marseille, France; IHU-Méditerranée Infection, Marseille, France. Electronic address:

The mortality rate reported from the Netherlands was 3.3 times higher than that observed from the French National Reference Center for Q fever. In the French National reference center for Q fever, we propose the early detection of factors that promote complications (anticardiolipins and underlying valvulopathy with transthoracic cardiac echocardiography), the early detection of persistent C. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.021DOI Listing
February 2019

Healthcare-asociated pneumonia:Any reasons to still utilize this label in 2019?

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Scottish Centre for Respiratory Research, University of Dundee, NinewellsHospital and Medical School, Dundee, DD1 9SY, UK.

Backround: There is an ongoing controversy on the role of the HCAP label in the treatment of patients with pneumonia.

Objective: To provide an update of the literature on patients meeting criteria for healthcare-associated pneumonia 2014-2018.

Sources: The review was based on a systematic literature search using Pub Med-Central full-text archive of biomedical and life sciences journal literature at the U. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.022DOI Listing
February 2019
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Clearance of carbapenemase-producing Enterobacteriaceae (CPE) carriage: a comparative study of NDM-1 and KPC CPE - author's reply.

Clin Microbiol Infect 2019 Feb 25. Epub 2019 Feb 25.

Office for Infection Control, Asan Medical Center, Seoul, Republic of Korea; Department of Infectious Diseases, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2019.02.012DOI Listing
February 2019
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Trained innate immunity and resistance to Mycobacterium tuberculosis infection.

Clin Microbiol Infect 2019 Feb 23. Epub 2019 Feb 23.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences (RIMLS), Radboudumc, Nijmegen, the Netherlands. Electronic address:

Background: Some individuals, even when heavily exposed to an infectious tuberculosis patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early clearance' of Mycobacterium tuberculosis is associated with a history of bacillus Calmette-Guérin (BCG) vaccination. As BCG vaccination can boost innate immune responses through a process termed 'trained immunity', we hypothesize that BCG-induced trained innate immunity contributes to early clearance of M. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.015DOI Listing
February 2019
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Lyme Disease Overdiagnosis in a Large Healthcare System: A Population-based, Retrospective Study.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

Public Health and Preventive Medicine Department, U.S. Air Force School of Aerospace Medicine, Wright-Patterson AFB, OH, USA.

Objectives: To evaluate the impact of false positive IgM immunoblots on Lyme disease treatment and case reporting in a large healthcare system.

Methods: We obtained results of all Lyme disease serologic tests ordered at U.S. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.020DOI Listing
February 2019
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Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, the Netherlands.

Objectives: The prevalence of resistance genes in two important anaerobic genera, Bacteroides and Prevotella, was assessed by applying PCR specifically directed to genes of interest.

Methods: A total of 101 Bacteroides spp. and 99 Prevotella spp. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.017DOI Listing
February 2019

Clostridioides difficile infection in outpatient settings - the need for studies on clinical impact.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

Division of Infectious Diseases and Infection Control, University Hospital Basel, University Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel, Switzerland. Electronic address:

In this issue of CMI, a study by Barbut et al. reports about the detection of toxigenic Clostridioides difficile in patients presenting to general practitioners due to diarrhoea or other gastrointestinal disorders. Among 2541 patients included in this study, toxigenic C. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.019DOI Listing
February 2019

The predictors and economic burden of early-, mid- and late-onset cardiac implantable electronic device infections: a retrospective cohort study in Ontario, Canada.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

The rate of cardiac implantable electronic device (CIED) infection is increasing with time. We sought to determine the predictors, relative mortality, and cost burden of early-, mid- and late-onset CIED infections. We conducted a retrospective cohort study of all CIED implantations in Ontario, Canada between April 2013 and March 2016. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.009DOI Listing
February 2019

Intestinal schistosomiasis: a very long-lived tropical parasite.

Clin Microbiol Infect 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

We report a case of intestinal schistosomiasis in a patient who had not travelled outside Europe after migrating 20 years ago. Images of the Schistosoma mansoni eggs are shown that confirm the active nature of the infection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.014DOI Listing
February 2019
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The impact of vaccines on heterologous adaptive immunity.

Clin Microbiol Infect 2019 Feb 20. Epub 2019 Feb 20.

Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia.

Background: Vaccines induce antigen-specific memory in adaptive immune cells that enable long-lived protection against the target pathogen. In addition to this, several vaccines have beneficial effects greater than protection against their target pathogen. These non-specific effects are proposed to be the result of vaccine-induced immunomodulation. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.016DOI Listing
February 2019
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New potential biomarkers to assess efficacy of protection afforded by vaccine candidates against tuberculosis.

Clin Microbiol Infect 2019 Feb 20. Epub 2019 Feb 20.

Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C. Biotecnología Médica y Farmacéutica. Av. Normalistas 800, Col. Colinas de la Normal, Guadalajara, Jalisco, Mexico, 44270. Electronic address:

Here, I describe the most recent findings of what host immune factors seem to be involved in successfully controlling M. tuberculosis infection in humans, leading to Latent TB Infection (LTBI) and how such potential biomarkers could be incorporated in preclinical and clinical trials of new vaccine candidates, especially those aimed against LTBI. I consider that there is not that much information as to produce a review, but that considering the clinical trials of over a dozen new vaccine candidates against TB, it could be a timely piece of work for the community evaluating these candidates or developing new ones. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.010DOI Listing
February 2019

Infection control procedures for extensively drug-resistant bacteria and related adverse effects: the experience at the Lyon University Hospitals from 2011 to 2017.

Clin Microbiol Infect 2019 Feb 20. Epub 2019 Feb 20.

Service d'Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, France; Laboratoire des Pathogènes Emergents - Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2019.02.013DOI Listing
February 2019

Lytic transglycosylase contributes to the survival of lipooligosaccharide-deficient, colistin-dependent Acinetobacter baumannii.

Clin Microbiol Infect 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular Cell Biology and Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea. Electronic address:

Objectives: The phenomenon of colistin dependence in Acinetobacter baumannii has been described in a situation in which colistin is now considered as the last resort for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. In this study, we aimed to reveal a gene associated with colistin dependence in A. baumannii. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193005
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http://dx.doi.org/10.1016/j.cmi.2019.02.004DOI Listing
February 2019
3 Reads

European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

Clin Microbiol Infect 2019 Feb 18. Epub 2019 Feb 18.

Statens Serum Institut, Copenhagen, Denmark.

Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe.

Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excl. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.011DOI Listing
February 2019
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Isavuconazole MICs distribution of 29 yeast species responsible for invasive infections (2015-2017).

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses & Antifungal, UMR2000, CNRS, Paris, France; Université Paris Descartes, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, APHP, IHU Imagine. Electronic address:

Objectives: Isavuconazole is a recent extended-spectrum triazole with activity against yeasts. However, few data are available on the in vitro activity on rare yeast species. We report minimum inhibitory concentration (MIC) distribution of isavuconazole compared to fluconazole for a large collection of common or rare yeasts. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.007DOI Listing
February 2019

Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Department of Hepato-gastroenterology, Chang Gung Memorial Hospital, Linkou Branch, Taiwan; Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

Objectives: We aimed to investigate immunity against hepatitis B surface antigen (HBsAg) mutants before and after boosters in adolescents who lost antibodies against HBsAg (anti-HBs) despite neonatal vaccination.

Methods: We recruited 142 participants from 15 to 21 years old, who had received complete vaccination in infancy but became anti-HBs-negative. Cellular immunity to HBsAg and T-cell epitope variants was assessed before and after boosters. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.003DOI Listing
February 2019
2 Reads

Universal screening for Clostridioides difficile in a tertiary hospital: risk factors for carriage and clinical disease.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Internal Medicine C, Sheba Medical Center, Israel; Sackler school of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: The role of asymptomatic carriers in CDI epidemiology is not fully understood. Our aim was to evaluate CD carriage prevalence on admission, associated risk factors and the risk to develop CDI.

Methods: A ten-week surveillance program for CD carriage of all medical patients admitted to the Sheba Medical Center was implemented, utilizing admission rectal swab PCR (Xpert C. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.002DOI Listing
February 2019
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Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics.

Clin Microbiol Infect 2019 Feb 14. Epub 2019 Feb 14.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

Background: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In the absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, leading to inappropriate treatment of this serious eye condition.

Objectives: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.017DOI Listing
February 2019
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Reply to Mullish et al. "Faecal microbiota transplant for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice?"

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Infection Control Programme and WHO Collaborating Centre, Geneva University Hospitals, Geneva, Switzerland; Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.cmi.2019.02.001DOI Listing
February 2019
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Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

Clin Microbiol Infect 2019 Feb 14. Epub 2019 Feb 14.

Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objectives: The aim was to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.

Methods: According to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.008DOI Listing
February 2019
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Trichoderma longibrachiatum-An unusual pathogen of fungal pericarditis.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology. Hospital Universitario 12 de Octubre. Madrid. Spain.

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http://dx.doi.org/10.1016/j.cmi.2019.02.006DOI Listing
February 2019
2 Reads

Emergence of a ST2570 Klebsiella pneumoniae isolate carrying mcr-1 and bla recovered from a bloodstream infection in China.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2019.02.005DOI Listing
February 2019

An atypical morphology of Campylobacter: like a spirochete.

Authors:
B Thomas S Poussing

Clin Microbiol Infect 2019 Feb 12. Epub 2019 Feb 12.

Laboratoire de Biologie Médicale, Hopitaux Prives de Metz, Metz, France.

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http://dx.doi.org/10.1016/j.cmi.2019.01.018DOI Listing
February 2019
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Mycobacterium Tuberculosis infection among the elderly in 20 486 rural residents aged 50-70 years in Zhongmu County, China.

Clin Microbiol Infect 2019 Feb 7. Epub 2019 Feb 7.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objectives: Elderly individuals in rural China have been known to be at increased risk of contracting tuberculosis (TB) and developing active disease. This study aims to estimate the burden of mycobacterium tuberculosis (MTB) infection and to identify potential targeted subgroups for infection control.

Methods: As part of the investigation of an interventional study, 50- to 70-year-old rural residents in Zhongmu County were targeted for MTB infection testing using QuantiFERON-TB Gold In-Tube (QFT). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.021DOI Listing
February 2019
2 Reads

Erratum to 'High-quality endoscope reprocessing decreases endoscope contamination' [Clinical Microbiology and Infection, Volume 24, Issue 10 (October 2018) Pages 1101.e1-1101.e6].

Clin Microbiol Infect 2019 Mar 4;25(3):396. Epub 2019 Feb 4.

Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2019.01.020DOI Listing
March 2019
2 Reads

Immunogenicity and safety of an accelerated hepatitis E vaccination schedule in healthy adults: a randomized, controlled, open-label, phase IV trial.

Clin Microbiol Infect 2019 Jan 31. Epub 2019 Jan 31.

Institute of Immunization and Prevention, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, China. Electronic address:

Objectives: This study aimed to evaluate the immunogenicity and safety of a hepatitis E (HE) vaccine using an accelerated vaccination schedule (vaccine doses at 0, 7 and 21 days).

Methods: A total of 126 participants aged ≥18 years were randomly assigned to receive the hepatitis E virus vaccine in either the accelerated group (0, 7 and 21 days) or the routine group (0, 1 and 6 months). Serology samples were obtained at 0, 21, 28 and 51 days, and 7 months in the accelerated group, or 0, 1, 2 and 7 months in the routine group after the first vaccine injection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.015DOI Listing
January 2019
1 Read

Diagnostic approach to Encephalitis and Meningoencephalitis in Adult Returning Travellers.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Infectious Diseases and Tropical Medicine, University Hospital, Grenoble, France.

Background: Encephalitis and meningoencephalitis are severe, sometime life-threatening infections of the central nervous system. Travellers may be exposed to a variety of neurotropic pathogens.

Aims: We propose to review known infectious causes of encephalitis in adults acquired outside Europe, and how to identify them. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.008DOI Listing
January 2019

ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Division of Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena / Department of Medicine, University of Seville / Biomedicine Institute of Seville (IBiS), Seville, Spain.

Scope: The aim of these guidelines is to provide recommendations for decolonizing regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings.

Methods: These evidence-based guidelines were produced after a systematic review of published studies on decolonization interventions targeting the following MDR-GNB: third-generation cephalosporin-resistant Enterobacteriaceae (3GCephRE), carbapenem-resistant Enterobacteriaceae (CRE), aminoglycoside-resistant Enterobacteriaceae (AGRE), fluoroquinolone-resistant Enterobacteriaceae (FQRE), extremely drug-resistant Pseudomonas aeruginosa (XDRPA), carbapenem-resistant Acinetobacter baumannii (CRAB), cotrimoxazole-resistant Stenotrophomonas maltophilia (CRSM), colistin-resistant Gram-negative organisms (CoRGNB), and pan-drug-resistant Gram-negative organisms (PDRGNB). The recommendations are grouped by MDR-GNB species. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.005DOI Listing
January 2019
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Encephalitis and meningoencephalitis: chasing the culprit.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Neurology Division, Geneva University Hospitals, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.cmi.2019.01.013DOI Listing
January 2019

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Sorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé publique, Paris, France; Université de Versailles Saint-Quentin-en-Yvelines, UVSQ, UFR de Médecine, Versailles, France; Assistance Publique - Hôpitaux de Paris APHP, Hôpital Ambroise Paré, Service de Médecine Interne, Boulogne Billancourt, France.

Objectives: We aimed to identify patients' clinical characteristics associated with respiratory viruses identified among patients presenting with influenza-like illness (ILI).

Methods: A sample of patients of all ages presenting with ILI was included by physicians of the French Sentinelles network during two seasons (2015/16 and 2016/17). Nasopharyngeal samples were tested for the presence of influenza virus (IV), respiratory syncytial virus (RSV), human rhinovirus (HRV) and human metapneumovirus (HMPV). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.014DOI Listing
January 2019
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Concurrent cerebral aspergillosis and abdominal mucormycosis during ibrutinib therapy for chronic lymphocytic leukaemia.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Mycologie Moléculaire, UMR 2000, Paris, France.

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http://dx.doi.org/10.1016/j.cmi.2019.01.016DOI Listing
January 2019
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Author gender and editors' decisions at Clinical Microbiology and Infection.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Clinical Microbiology and Infection, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.cmi.2019.01.012DOI Listing
January 2019

Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report.

Clin Microbiol Infect 2019 Feb 26;25(2):261-263. Epub 2018 Oct 26.

Laboratoire de Parasitologie et Mycologie Médicale, Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France.

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http://dx.doi.org/10.1016/j.cmi.2018.10.004DOI Listing
February 2019

High prevalence of currently circulating Bordetella pertussis isolates not producing vaccine antigen pertactin in Slovenia.

Clin Microbiol Infect 2019 Feb 26;25(2):258-260. Epub 2018 Oct 26.

Institute of Biomedicine, Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland; Department of Medical Microbiology, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2018.10.005DOI Listing
February 2019
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A heartfelt thank-you to our peer-reviewers.

Clin Microbiol Infect 2019 Feb;25(2):127

CMI Editorial Office.

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http://dx.doi.org/10.1016/j.cmi.2018.12.023DOI Listing
February 2019

Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial.

Clin Microbiol Infect 2019 Jan 25. Epub 2019 Jan 25.

Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton MP131, Southampton General Hospital, Tremona Road, Southampton, UK.

Objectives: The aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI).

Methods: A 2 × 2 factorial placebo controlled randomized trial in primary care. The participants were 382 women aged 18-70 years with symptoms of dysuria, urgency, or frequency of urination and suspected by a clinician to have a lower UTI. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.011DOI Listing
January 2019
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Isolation of human GBS CC67 strains with high adhesion ability to HBMECs.

Clin Microbiol Infect 2019 Jan 25. Epub 2019 Jan 25.

Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Institute of Fisheries, Nanning 530021, China; Bacteria Laboratory, Guangxi Centre for Disease Control and Prevention, Nanning 530021, Guangxi, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193002
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http://dx.doi.org/10.1016/j.cmi.2019.01.009DOI Listing
January 2019
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Monitoring treatment response in chronic pulmonary aspergillosis: role of clinical, spirometric and immunological markers.

Clin Microbiol Infect 2019 Jan 25. Epub 2019 Jan 25.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

Objectives: The treatment response in chronic pulmonary aspergillosis (CPA) is usually assessed based on the improvement in clinical and imaging findings. Herein, we evaluate serum Aspergillus fumigatus-specific IgG, serum galactomannan, weight change, and lung function for assessing treatment response in subjects with CPA.

Methods: We categorized treatment response as favourable (improved or stable clinical response with radiologically improved or stable disease) or unfavourable (worsening of symptoms or radiological progression) after 6 months of treatment with antifungal azoles. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.007DOI Listing
January 2019
2 Reads