4,364,248 results match your criteria Clinical Medicine Insights: Trauma and Intensive Medicine [Journal]


Rare Case of Surgical Treatment of a Giant Aortic Arch False Aneurysm.

Aorta (Stamford) 2018 Jun 22;6(3):88-91. Epub 2019 Feb 22.

Department of Vascular Surgery, City Multiservice Hospital No. 2, Saint Petersburg, Russia.

The authors present a clinical case of a 44-year-old male patient with a chronic giant aortic arch pseudoaneurysm with a diameter of 136 × 72 mm. The open resection of false aneurysm was accomplished without artificial circulation. Repair was performed with temporary ascending-to-descending and brachiocephalic bypass without cardiopulmonary bypass. Read More

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http://dx.doi.org/10.1055/s-0039-1678553DOI Listing

Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System.

Thorac Cardiovasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Morfology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, Sant'Anna Hospital, University of Ferrara, Ferrara, Italy.

Background:  This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease.

Methods:  Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Read More

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http://dx.doi.org/10.1055/s-0039-1678612DOI Listing
February 2019

Innovative Service Delivery Models for Serving Children with Speech Sound Disorders.

Semin Speech Lang 2019 Mar 22;40(2):113-123. Epub 2019 Feb 22.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana.

Service delivery variables that may have an impact on the treatment outcomes of children with speech sound disorders include the number and duration of intervention sessions, distribution of the sessions over time, and the format (group intervention or individual intervention). In this article, we briefly review these variables and the recommendations for the most effective service delivery components for children with speech sound disorders. We then describe innovative, collaborative service delivery models for preschoolers and school-age children with speech sound disorder. Read More

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http://dx.doi.org/10.1055/s-0039-1677762DOI Listing

What Do Children with Speech Sound Disorders Think about Their Talking?

Semin Speech Lang 2019 Mar 22;40(2):94-104. Epub 2019 Feb 22.

School of Teacher Education, Charles Sturt University, Australia.

Investigating children's feelings and attitudes toward talking assists speech-language pathologists (SLPs) to understand experiences of communication and the impact of speech sound disorders (SSD). This, in turn, can assist SLPs in identifying appropriate intervention for children with SSD that addresses the needs of children, and their communication partners. This paper draws on data from the Sound Start Study in Australia to explore the attitudes toward talking of 132 preschool-aged children with SSD and the relationship between children's attitudes, speech accuracy, and parent-reported intelligibility and participation. Read More

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http://dx.doi.org/10.1055/s-0039-1677760DOI Listing

Clinical Challenges: Assessing Toddler Speech Sound Productions.

Authors:
Shari L DeVeney

Semin Speech Lang 2019 Mar 22;40(2):81-93. Epub 2019 Feb 22.

Department of Special Education and Communication Disorders, University of Nebraska at Omaha, Omaha, Nebraska.

When assessing toddler speech sound productions, speech-language pathologists (SLPs) must be mindful of several important but not insurmountable limitations inherent to working with this young population for whom speech sound production may be of concern. These limitations include: (1) inconsistencies in recommended connected speech sampling size and phonetic transcription accuracy, (2) the prevalence of typical intraword variability for toddlers, (3) limited information regarding the reliability of informal measures of analysis, and (4) irregularities in available normative data for referencing speech sound development and mastery. This article includes a discussion of these factors, an overview of key assessment tools for single-word and connected-speech sampling, advice for current evidence-based practice procedures, and a thorough but not exhaustive listing of opportunities to improve clinical practice in this area. Read More

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http://dx.doi.org/10.1055/s-0039-1677759DOI Listing

Accuracy of Routine Prenatal Genetic Screening in Patients Referred for Genetic Counseling.

Am J Perinatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware.

Objective:  The American College of Obstetricians and Gynecologists (ACOG) guidelines recommend routine prenatal screening for genetic diseases that could affect the pregnancy. We sought to determine the rate of missed genetic information in the general obstetrician's routine prenatal genetic screening process.

Study Design:  This is a sequential case series of women referred for genetic counseling between March and August of 2015. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678533
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http://dx.doi.org/10.1055/s-0039-1678533DOI Listing
February 2019
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Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Previously, we demonstrated that dendritic spine density (DSD) in deep layer 3 of the primary auditory cortex (A1) lower, due to having fewer small spines, in subjects with schizophrenia (SZ) than non-psychiatric control (NPC) subjects. We also previously demonstrated that microtubule-associated-protein-2 immunoreactivity (MAP2-IR) in A1 deep layer 3 is lower, and positively correlated with DSD, in SZ subjects. Here, we first sought to confirm these findings in an independent cohort of 25 SZ-NPC subject pairs (cohort 1). Read More

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http://dx.doi.org/10.1038/s41386-019-0350-7DOI Listing
February 2019

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery, University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, AUSTRALIA.

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c4DOI Listing
February 2019

A simplified fabrication technique for cellularized high-collagen dermal equivalents.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Product Development Group Zurich, Eidgenossische Technische Hochschule Zurich Departement Maschinenbau und Verfahrenstechnik, Zurich, ZH, SWITZERLAND.

Human autologous bioengineered skin has been successfully developed and used to treat skin injuries in a growing number of cases. In current clinical studies, the biomaterial used is fabricated via plastic compression of collagen hydrogel to increase the density and stability of the tissue. To further facilitate clinical adoption of bioengineered skin, the fabrication technique needs to be improved in terms of standardization and automation. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c5DOI Listing
February 2019

A comparison of exhaled breath online and offline measurements for diabetes pre-screening by graphene-based sensor: from powder processing to clinical monitoring prototype.

J Breath Res 2019 Feb 22. Epub 2019 Feb 22.

SRM University, Kattankulathur, Tamil Nadu, INDIA.

Several breath analysis studies have suggested a correlation between blood glucose (BG) levels and breath acetone, indicating acetone as a primary biomarker in exhaled breath for diabetes diagnosis. Herein, we have (i) fabricated and validated graphene based chemi-resistive sensors for selective and sensitive detection of acetone, (ii) performed offline breath analysis by static gas sensing setup to acquire olfactory signal and (iii) developed an LED based portable on/off binary e-nose system for pre-screening diabetes through online analysis. The fabricated sensors showed selective detection for acetone with high sensitivity (5. Read More

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http://dx.doi.org/10.1088/1752-7163/ab09aeDOI Listing
February 2019

Toward Tissue-engineering of Nasal Cartilages.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. Electronic address:

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.025DOI Listing
February 2019

VarGrouper - a Bioinformatic Tool for Local Haplotyping of Deletion-Insertion Variants from Next-generation Sequencing Data Post Variant Calling.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, Harvard Medical School / Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Accurate genetic variant representation through nomenclature and annotation is essential for understanding functional consequence and properly noting the presence of variants across time, assays, and laboratories. Current variant calling algorithms detect single deletion-insertion variants as multiple indel and/or substitution variants from next-generation sequencing data. Consequently, these variants are separately annotated in bioinformatics pipelines, leading to inaccurate variant representation. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.12.003DOI Listing
February 2019

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Clinical Pharmacology.

The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients. Testing methods for variants in ABCB1, CBR3, COMT, CYP3A7, C8ORF34, FCGR2A, FCGR3A, HAS3, NT5C2, NUDT15, SBF2, SEMA3C, SLC16A5, SLC28A3, SOD2, TLR4, and TPMT were validated in a CLIA-accredited laboratory. As no known reference materials were available, DNA samples that were from Coriell Cell Repositories (Camden, NJ) were used for the analytical validation studies. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.009DOI Listing
February 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Hematopathology, The University of Texas MD Anderson Cancer Center, Houston; Baylor Miraca Genetics Laboratories. Electronic address:

The emergence of highly sensitive molecular diagnostic approaches such as droplet digital PCR has allowed the accurate identification of low-frequency variant alleles in clinical specimens; however, the multiplex capabilities of droplet digital PCR for variant detection are inadequate. The incorporation of molecular barcodes or unique IDs into next-generation sequencing libraries through PCR has enabled the detection of low-frequency variant alleles across multiple genomic regions. However, rational library preparation and sequencing data analytical strategies that integrate molecular barcodes have rarely been applied to clinical settings. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
February 2019

Alternative definitions of cerebral aneurysm morphological parameters have an impact on rupture risk determination.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Medical University of Silesia, School of Medicine in Katowice, Department of Neurosurgery, Katowice, Poland.

Background: A discrepancy between definitions of morphologic parameters describing cerebral aneurysms across studies leads to conflicting results concerning performances of these factors and threshold values for rupture status prediction. The aim of the study was to evaluate how various definitions of morphologic parameters may influence the prediction of the risk for aneurysm rupture.

Material And Methods: A total of 425 intracranial aneurysms were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.283DOI Listing
February 2019

The MR Imaging Appearance of Endoscopic Endonasal Skull Base Defect Reconstruction Using Free Mucosal Graft.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Division of Otolaryngology, Albany Medical Center, Albany, New York, 12208, U.S.A.

Objective: At our institution, skull base reconstruction using a free mucosal graft from the nasal cavity floor has been the standardized technique after pituitary adenoma resection via transsellar approach. This study describes the expected appearance of the reconstruction on postoperative MRI scans and assesses its integrity and impact on the sinonasal cavity.

Methods: Fifty patients were selected, and their EMR were reviewed for postoperative course, SNOT-22 scores, and nasal endoscopy reports. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.010DOI Listing
February 2019

Unilateral Thalamic Deep Brain Stimulation vs. Focused Ultrasound Thalamotomy for Essential Tremor.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Departments of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: The predominant neurosurgical approach to medication-refractory essential tremor (ET) is thalamic deep brain stimulation (DBS). The emergence of magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has reawakened the debate surrounding the use of DBS vs. thalamotomy for this indication. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.281DOI Listing
February 2019

Pediatric Intracranial Aneurysms: Favorable Outcomes despite Rareness and Complexity.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Pediatric intracranial aneurysms (IAs) are rare and differ from their adult counterparts in terms of their aneurysmal characteristics, presentation, treatment, and outcomes. Their treatment is often more difficult and complex compared to adults. However, studies outlining the clinical impact of pediatric IAs remain sparse. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.280DOI Listing
February 2019

Elective treatment of additional and recurrent aneurysms in patients with a previous subarachnoid hemorrhage: A single-center analysis of complications and clinical outcome.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Center for Neurosurgery, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.

Objective: Subarachnoid hemorrhage (SAH) can be associated with a degree of resulting brain damage and subsequent reorganization of the central nervous system. The aim of this study was to evaluate complication rates and clinical outcome in patients with a previous subarachnoid haemorrhage (SAH) that were treated for a recurrent or an additional, initially unruptured aneurysm.

Methods: A retrospective, single-center study was conducted for patients that underwent elective treatment by surgical or endovascular means between 2010 and 2018. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.279DOI Listing
February 2019

Diagnostic and prognostic potential of serum cell-free microRNA-214 in glioma.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Linyi People's Hospital, Shandong University, Linyi, Shandong Province, China. Electronic address:

Objectives: We aimed to expound feasibility of serum cell-free microRNA-214 (miR-214) as a noninvasive biomarker for glioma in this study.

Patients And Methods: We detected expression of miR-214 in medium from 2 glioma cell lines to confirm whether it is secretory in screening phase. Then we verified cell-free miR-214 expression in serum samples from an independent set of 100 preoperative glioma patients, 30 matching postoperative patients and 100 healthy controls. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.009DOI Listing
February 2019

Dysphagia prevention in anterior cervical discectomy surgery.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Neurosurgical Clinic, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, School of Medicine, Palermo, Italy.

Background: Dysphagia is a common complication after anterior cervical discectomy surgery (ACDS). Recent studies have shown that reducing the endotracheal tube cuff pressure (ETCP), local irrigation with methylprednisolone, and minimizing the pharynx/esophagus retraction can decrease the incidence of post-operative dysphagia following ACDS. This is the first study assessing the efficacy of all these three measures simultaneously. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.273DOI Listing
February 2019

Anaphylaxis to hidden pea protein: a Canadian pediatric case series.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jaip.2019.02.010DOI Listing
February 2019

Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability of airway inflammation.

Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193017
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http://dx.doi.org/10.1016/j.jaip.2019.02.011DOI Listing
February 2019
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Transthoracic sonographic assessment of B-line scores during ascent to altitude among healthy trekkers.

Respir Physiol Neurobiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

Portable sonography-determined B-lines can indicate pulmonary interstitial edema. We sought to determine the incidence of subclinical pulmonary edema measured by sonographic B-lines among lowland trekkers ascending to high altitude in the Nepal Himalaya. Twenty healthy trekkers underwent portable sonographic examinations and arterial blood draws during ascent to 5160 m over ten days. Read More

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http://dx.doi.org/10.1016/j.resp.2019.02.005DOI Listing
February 2019

Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing.

Nanomedicine 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address:

A nanotube assisted microwave electroporation (NAME) technique is demonstrated for delivering molecular biosensors into viable bacteria for multiplex single cell pathogen identification to advance rapid diagnostics in clinical microbiology. Due to the small volume of a bacterial cell (~femtoliter), the intracellular concentration of the target molecule is high, which results in a strong signal for single cell detection without amplification. The NAME procedure can be completed in as little as 30minutes and can achieve over 90% transformation efficiency. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.015DOI Listing
February 2019

Evaluation of ligament laxity during pregnancy.

J Gynecol Obstet Hum Reprod 2019 Feb 19. Epub 2019 Feb 19.

Institut Pprime. Axe RoBioSS, CNRS UPR 3346 Université de Poitiers. Téléport 2, boulevard Marie et Pierre Curie BP 30179, 86962, Futuroscope, France. Electronic address:

Objective: Pregnancy-related changes in ligament laxity have been shown to be associated with various disorders such as back pain or pelvic floor disorders. The purpose of this study was to assess laxity changes during pregnancy by confronting different methods in order to suggest a simple clinical tool helping to prevent the aforementioned problems.

Design: 17 pregnant women were evaluated at the first, second and third trimesters as cases and 16 non-pregnant women participated as controls. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.02.009DOI Listing
February 2019

Master Clinician Review: Parental Depression and Family Health and Wellness: What Clinicians Can Do and Reflections on Opportunities for the Future.

J Am Acad Child Adolesc Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Boston Children's Hospital, MA. Electronic address:

The study of parental depression in families with depressed children, and the development of appropriate family prevention strategies to assist families with depressed parents, have expanded and improved significantly over the last thirty years. This paper highlights an evidence-informed approach for clinicians dealing with depressed parents in different settings, addressing when a parent presents with depression, and when parental depression is encountered in treating a child with behavior health concerns. Some reflection about key contextual, policy, and systems issues is offered, as these so often determine what is and is not possible in a clinical encounter. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.008DOI Listing
February 2019

Prevalence of antibodies to lung self-antigens (Kα1 tubulin and collagen V) and donor specific antibodies to HLA in lung transplant recipients and implications for lung transplant outcomes: Single center experience.

Transpl Immunol 2019 Feb 19. Epub 2019 Feb 19.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Purpose: For patients with end stage lung disease, lung transplantation (LT) remains the only definitive treatment option. Long term survival post LT is limited by acute and chronic allograft dysfunction. Antibodies to lung self-antigens Kα1Tubulin and collagen V (autoantibodies) have been implicated in adverse outcomes post LT. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.006DOI Listing
February 2019

Treatment efficacy of drug-resistant tuberculosis in Bashkortostan, Russia: a retrospective cohort study.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Institute of Genomics, University of Tartu, Tartu, Riia, 23b, Estonia. Electronic address:

Background: Russia, together with other former Soviet Union countries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-resistant strains.

Objectives: The aim of the study was to evaluate treatment efficacy of patients with multidrug-resistant (MDR), extensively drug-resistant (XDR) and drug-susceptible (DSTB) tuberculosis in the most populous region of Russia (Bashkortostan) that borders with Central Asia. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.010DOI Listing
February 2019

Multicenter clinical experience of real life Dalbavancin use in gram-positive infections.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address:

Dalbavancin, a lipoglycopeptide with prolonged half-life approved for the treatment of acute bacterial skin-and-soft-tissue-infections, can be used for the treatment of infections caused by gram-positive bacteria requiring long term treatment such as endocarditis, prosthetic joint infections (PJI) or osteomyelitis. Clinical data is limited in these settings.

Objectives: To evaluate indications, safety, tolerability and long-term outcomes of dalbavancin-treated patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.013DOI Listing
February 2019

The Stability of Treatment Preferences among Patients with Advanced Cancer.

J Pain Symptom Manage 2019 Feb 19. Epub 2019 Feb 19.

Cornell Center for Research on End-of-Life Care, Weill Cornell Medicine, New York, New York, U.S.A.; Division of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, U.S.A.. Electronic address:

Context: Stability of patients' treatment preferences has important implications for decisions about concurrent and future treatment.

Objectives: To examine the stability of treatment preferences and correlates among patients with advanced cancer.

Methods: In this cohort, 104 patients with metastatic cancer, progression after at least one chemotherapy regimen and an oncologist-estimated life-expectancy of ≤ six months participated in structured interviews following clinical visits in which patients' recent scans were discussed. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.01.016DOI Listing
February 2019

AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION FOR TREATMENT-REFRACTORY RELAPSING MULTIPLE SCLEROSIS: POSITION STATEMENT FROM THE AMERICAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Multiple sclerosis (MS) is a chronic, disabling, immune-mediated, central nervous system demyelinating and degenerative disease. Approved disease modifying therapies may be incompletely effective in some patients with highly active relapsing disease and high risk of disability. Immunoablative or myeloablative therapy followed by autologous hematopoietic cell transplantation (AHCT) has been investigated in retrospective studies, clinical trials, and meta-analyses/systematic reviews as an approach to address this unmet clinical need. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.014DOI Listing
February 2019

Risk factors and predictive scoring system for post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan. Electronic address:

We analyzed data of 64,539 consecutive patients in the national Japanese transplant registry, including 40,195 after allogeneic stem cell transplantation, 24,215 after autologous stem cell transplantation, and 129 after syngeneic stem cell transplantation, and 299 developed Epstein-Barr virus positive post-transplant lymphoproliferative disorder. The probability at 2 years was 0.79% after allogeneic transplantation, 0. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.016DOI Listing
February 2019

Accuracy and usability of single-lead ECG from smartphones - A clinical study.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The objective was to evaluate the accuracy, usability and diagnostic capabilities of smartphone ECG (spECG) in both patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.006DOI Listing
February 2019

Targeting ERK1/2 protein-serine/threonine kinases in human cancers.

Authors:
Robert Roskoski

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC, 28742-8814, United States. Electronic address:

ERK1 and ERK2 are key protein kinases that contribute to the Ras-Raf-MEK-ERK MAP kinase signalling module. This pathway participates in the control of numerous processes including apoptosis, cell proliferation, the immune response, nervous system function, and RNA synthesis and processing. MEK1/2 activate human ERK1/2 by first catalyzing the phosphorylation of Y204/187 and then T202/185, both residues of which occur within the activation segment. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.039DOI Listing
February 2019

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Shipping warehouse No. 5, Beijing, 100700, China. Electronic address:

The role of gut microbiota in the management of diabetes has been shown. Several current trials are investigating the effect of probiotics and prebiotics, which are widely used to modulate intestinal microbiota, on inflammatory factors and biomarkers of oxidative stress in diabetic patients; however, their findings are controversial. The aim of the current meta-analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high-sensitivity C-reactive protein (hs-CRP) and biomarkers of oxidative stress in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.016DOI Listing
February 2019

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing
February 2019

Common pathogenic mechanism in patients with dropped head syndrome caused by different mutations in the MYH7 gene.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Medical Genetics Laboratory, Petrovsky Russian Research Center of Surgery, Moscow 119991, Russia; Pirogov Russian National Research Medical University, Moscow 117997, Russia.

Mutations in the MYH7 gene are the source of an allelic series of diseases, including various cardiomyopathies and skeletal myopathies that usually manifest in adulthood. We observed a 1.5 y. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.011DOI Listing
February 2019

The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Sciences, North Carolina State College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

Causative mutations for familial dilated cardiomyopathy (DCM) have been identified in the phospholamban gene. There are many poorly understood aspects about familial DCM (variable penetrance, expression) which may be studied in natural animal models. We characterized genetic aspects of familial DCM in a canine model with a high incidence of sudden death. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.022DOI Listing
February 2019

Co-expression of cytokeratin and vimentin in colorectal Cancer highlights a subset of tumor buds and an atypical Cancer-associated stroma.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Institute of Pathology, University of Bern, Murtenstrasse 31, Bern, CH-3008. Electronic address:

Tumor buds in colorectal cancer are hypothesized to undergo a (partial) epithelial-mesenchymal transition (EMT). If so, Cytokeratin (CK) and Vimentin (VIM) co-expression is expected. CK+/VIM+ can also be found in some stromal cells, however their origin remains unclear. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.002DOI Listing
February 2019

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia. Electronic address:

Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic factors in patients with ESCC. Expression at both the mRNA and protein levels was investigated using real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.033DOI Listing
February 2019

Tumor PD-L1 expression in malignant pleural and peritoneal mesothelioma by Dako PD-L1 22C3 pharmDx and Dako PD-L1 28-8 pharmDx assays.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112; ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT, 84108.

Malignant mesothelioma (MM) is an aggressive neoplasm with poor prognosis. The Dako PD-L1 22C3 and 28-8 pharmDx assays are approved by the US Food and Drug Administration (FDA) as companion and complementary diagnostics for the anti-PD-1 drugs pembrolizumab and nivolumab, respectively. Data from multiple clinical trials indicate that immunotherapy has anti-tumor activity in advanced malignant pleural (MPM) and peritoneal mesothelioma (MPeM). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.001DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Combination treatment of preoperative embryo cryopreservation and endoscopic surgery (surgery-ART hybrid therapy) in infertile women with diminished ovarian reserve and uterine myomas or ovarian endometriomas.

J Minim Invasive Gynecol 2019 Feb 19. Epub 2019 Feb 19.

From the Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, (Drs. Kuroda, Nakagawa, and Sugiyama) Tokyo, Japan.

Study Objective: To analyze the clinical outcomes and predictive factors for the therapeutic effect of combination treatment of preoperative embryo cryopreservation and endoscopic surgery ('surgery-assisted reproductive technology [ART] hybrid therapy') in infertile women with diminished ovarian reserve (DOR) with uterine fibroids and/or ovarian endometriomas.

Design: A retrospective cohort study (Canadian Task Force Classification II-2) SETTING: Data from all patients who underwent surgery-ART hybrid therapy at Juntendo University Hospital and Sugiyama Clinic from 2014 to 2016 were analyzed retrospectively. We compared women who experienced livebirth (success group) and implantation failure or miscarriage (failure group) after surgery-ART hybrid therapy and evaluate the predictive factors for livebirth. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.008DOI Listing
February 2019

Clinical and genetic characteristics of unusual G12P [11] rotavirus strains recovered from neonates: A study from Pune, Western India.

Infect Genet Evol 2019 Feb 19. Epub 2019 Feb 19.

Enteric Viruses Group, ICMR-National Institute of Virology, Pune, India. Electronic address:

Rotavirus infections in neonates are generally nosocomial, and differ from pediatric infections both clinically and epidemiologically. These infections are predominantly asymptomatic and often associated with unusual strains. Globally, so far limited data is available on rotavirus infections in neonates admitted at Neonatal Intensive Care Unit. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.014DOI Listing
February 2019

Biomaterializing the promise of cardiac tissue engineering.

Biotechnol Adv 2019 Feb 19. Epub 2019 Feb 19.

Division of Cardiology, Department of Medicine, Duke University Health System, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address:

During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.009DOI Listing
February 2019

Clostridioides difficile ribotypes isolated from domestic environment and from patients in Bangladesh.

Anaerobe 2019 Feb 19. Epub 2019 Feb 19.

University of Houston College of Pharmacy, Houston, Texas, USA.

Clostridioides difficile infection (CDI) is an emerging but often understudied infectious disease in developing countries. This study was aimed to isolate and characterize C. difficile from shoe sole swabs and diarrheal patient's stool samples in Bangladesh. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.010DOI Listing
February 2019

Skin and soft tissue infection caused by Cutibacterium (formerly Propionibacterium) avidum: report of eleven cases.

Anaerobe 2019 Feb 19. Epub 2019 Feb 19.

Section of Microbiology, University Hospital of Guadalajara, Guadalajara, Spain.

We describe the characteristics of 11 cases of skin and soft tissue infections due to Cutibacterium (formerly Propionibacterium) avidum. This microorganism should be considered a potential skin pathogen especially in patients with breast infections. The clinical outcome is usually good but serious infections such as necrotizing infections may occur. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.013DOI Listing
February 2019

The first case of human sparganosis in Poland and a review of the cases in Europe.

Parasitol Int 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.

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http://dx.doi.org/10.1016/j.parint.2019.02.005DOI Listing
February 2019
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