99 results match your criteria Clinical Medicine Insights: Pediatrics [Journal]


Ulnar Nerve Injuries Post Closed Forearm Fractures in Paediatric Population: A Review of the Literature.

Clin Med Insights Pediatr 2019 8;13:1179556519841876. Epub 2019 Apr 8.

Department of Orthopaedics and Traumatology, General Hospital of Agios Nikolaos, Crete, Greece.

Ulnar nerve injury as a result of closed forearm fractures in children is a rare but disastrous complication, affecting significantly the function of the upper extremity. The management of these injuries is still controversial in the literature. This is a review of small case series and case reports, in which an algorithm of treatment is proposed. Read More

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http://dx.doi.org/10.1177/1179556519841876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454652PMC

Association Between Maternal Feeding Practices and Symptoms of Anxiety and Depression Among 6-Year-Old Children.

Clin Med Insights Pediatr 2019 29;13:1179556519839334. Epub 2019 Mar 29.

Department of Social Medicine, Heritage College of Osteopathic Medicine, Ohio University, Dublin, OH, USA.

Background: Maternal feeding practices (MFPs) have been linked to childhood obesity and other eating disorders. However, population-based research examining the association between MFPs and children's emotional well-being is currently lacking.

Methods: We examined 1241 participants from Year 6 Follow-Up of the Infant Feeding Practices Study II, conducted from March to June 2012 in the United States. Read More

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http://dx.doi.org/10.1177/1179556519839334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444405PMC
March 2019
1 Read

Factors Associated With High Blood Lead Levels in a Sample of 100 Children in Tehran.

Clin Med Insights Pediatr 2019 25;13:1179556518825451. Epub 2019 Mar 25.

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Lead is considered a neurotoxic agent. We aimed to evaluate the blood lead level (BLL) in young population and determine probable risk factors of lead exposure in Iran.

Methods: In a cross-sectional study, a total of 100 children were entered and their BLLs were checked. Read More

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http://dx.doi.org/10.1177/1179556518825451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434433PMC
March 2019
1 Read

Reliability and Validity of the Japanese Version of the Physical Activity Questionnaire for Older Children.

Clin Med Insights Pediatr 2019 19;13:1179556519835833. Epub 2019 Mar 19.

Department of Community Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan.

Objectives: This study aimed to examine the reliability and validity of the Japanese version of the Physical Activity Questionnaire for Older Children (PAQ-C) in Japanese children aged 9 to 12 years.

Methods: A total of 210 children aged between 9 and 12 years participated. Internal consistency and test-retest reliability were evaluated using Cronbach alpha coefficient and intraclass correlation coefficient (ICC), respectively. Read More

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http://dx.doi.org/10.1177/1179556519835833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425525PMC

Emergence of OXA-48 Carbapenemase Producing in a Neonatal Intensive Care Unit in Marrakech, Morocco.

Clin Med Insights Pediatr 2019 14;13:1179556519834524. Epub 2019 Mar 14.

Laboratory of Bacteriology Virology, Hospital Arrazi, CHU Mohammed VI Marrakech, Marrakesh, Morocco.

Goal: This work aims to describe and explore the circumstances of appearance of producing OXA-48 carbapenemase, which has occurred in a neonatal intensive care service at the Mohammed VI University Hospital of Marrakech.

Results: During February 2015, the alert was triggered by the isolation of 6 isolates of with the same antibiotic susceptibility profile in the neonatal intensive care service, suggesting a possible outbreak. Blood cultures represented the main site of isolation of these isolates. Read More

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http://dx.doi.org/10.1177/1179556519834524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419253PMC

Knowledge of Neonatal Hyperbilirubinemia Among Primary Health Care Physicians: A Single-Center Experience.

Clin Med Insights Pediatr 2019 3;13:1179556518824375. Epub 2019 Mar 3.

Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background And Objectives: To evaluate the knowledge of the primary health care physicians (PHCP) in Kalubia governorate, Egypt, about the causes, diagnosis, complications, and treatment of neonatal hyperbilirubinemia (NHB).

Methods: Cross-sectional survey distributed by interview to 500 physicians working in the primary health care (PHC) sector in Kalubia.

Results: Out of 500 distributed surveys, 419 (84%) PHCP completed the questionnaire. Read More

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http://dx.doi.org/10.1177/1179556518824375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399760PMC

Infant Feeding Practices In a Diverse Group of Women: The Healthy Start Study.

Clin Med Insights Pediatr 2019 20;13:1179556518824362. Epub 2019 Jan 20.

Department of Pediatrics, School of Medicine, University of Colorado, Anschutz Medical Campus.

Background: To describe infant feeding practices among a diverse group of mother-offspring pairs and identify factors associated with adherence to the American Academy of Pediatrics (AAP) recommendations.

Methods: Data were analyzed from 835 mother-offspring dyads in The Healthy Start Study, an ongoing longitudinal prebirth cohort in Denver, Colorado. Maternal report of infant feeding practices was obtained at 4 to 6 months and 18 to 24 months postnatally. Read More

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http://dx.doi.org/10.1177/1179556518824362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348534PMC
January 2019
5 Reads

Corrigendum.

Authors:

Clin Med Insights Pediatr 2018 27;12:1179556518800765. Epub 2018 Dec 27.

[This corrects the article DOI: 10.1177/1179556518784300.]. Read More

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http://dx.doi.org/10.1177/1179556518800765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311548PMC
December 2018
1 Read

Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches.

Clin Med Insights Pediatr 2018 11;12:1179556518817322. Epub 2018 Dec 11.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. Read More

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http://dx.doi.org/10.1177/1179556518817322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295761PMC
December 2018
1 Read

Evaluating Accessible Sleep Health Information in Rural and Urban Contexts: Delivery Face-to-Face or Online?

Clin Med Insights Pediatr 2018 29;12:1179556518815168. Epub 2018 Nov 29.

Appleton Institute, Central Queensland University, Adelaide, SA, Australia.

Objective: New parents need education about infant sleep but is not universally available especially not in regional and rural areas. We delivered sleep education both face-to-face and online to test sleep knowledge acquisition for parents wherever they reside. Best practice delivery of accessible sleep health information for new families needs to be investigated more carefully in order for specialist services to be universally available. Read More

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http://journals.sagepub.com/doi/10.1177/1179556518815168
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http://dx.doi.org/10.1177/1179556518815168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295703PMC
November 2018
13 Reads

Neonatal Cholestasis: A Pandora's Box.

Clin Med Insights Pediatr 2018 6;12:1179556518805412. Epub 2018 Dec 6.

Department of Neonatology, Max Hospital, New Delhi, India.

Neonatal cholestasis (NC) is a diagnostic dilemma frequently countered in a neonatal care unit. Early diagnosis is vital for achieving an optimal patient outcome as many causes of cholestasis such as biliary atresia are time-sensitive and amenable to treatment if analyzed and treated early. Nonetheless, it is not generally simple to analyze these cases right on time as some of them are regularly missed due to the presence of pigmented stools, lack of newborn metabolic screening, and named as instances of prolonged jaundice. Read More

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http://dx.doi.org/10.1177/1179556518805412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295748PMC
December 2018
7 Reads

Parents' Expressions of Concerns and Hopes for the Future and Their Concomitant Assessments of Disability in Their Children.

Clin Med Insights Pediatr 2018 27;12:1179556518784948. Epub 2018 Jun 27.

Center for Clinical Epidemiology, Research Unit of Clinical Epidemiology, Odense University Hospital, Odense, Denmark.

Aim: To assess parents' ability to express their concerns and hopes for the future in their children with disability and assess their children's disability as well as to analyse these data for consistency.

Method: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours were asked to freely express their concerns and hopes for the future and to assess disability in their own children by employing a set of 26 International Classification of Functioning, Disability and Health, Children and Youth Version (ICF-CY) body function (b) codes and activity and participation (d) codes. A grounded theory approach was employed to systematize parents' expressions of concerns and hopes; then, parents scored qualifiers on a 5-step qualitative Likert scale. Read More

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http://dx.doi.org/10.1177/1179556518784948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055242PMC
June 2018
20 Reads

Factors Associated with Prescribing Broad-Spectrum Antibiotics for Children with Upper Respiratory Tract Infections in Ambulatory Care Settings.

Clin Med Insights Pediatr 2018 2;12:1179556518784300. Epub 2018 Jul 2.

Department of Clinical and Administrative Pharmacy Sciences, Howard University, Washington, DC, USA.

Objectives: Broad-spectrum antibiotics are frequently prescribed for children with upper respiratory tract infections (URI). Excessive use of broad-spectrum antibiotics leads to the emergence of resistant bacteria. This study aimed to identify factors associated with prescribing broad-spectrum antibiotics among children younger than 18 years presenting with URI in outpatient settings. Read More

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http://dx.doi.org/10.1177/1179556518784300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055249PMC
July 2018
19 Reads

Fit "N" Cool Kids: The Effects of Character Modeling and Goal Setting on Children's Physical Activity and Fruit and Vegetable Consumption.

Clin Med Insights Pediatr 2018 25;12:1179556518784296. Epub 2018 Jun 25.

College of Education, Health and Human Services, Kent State University, Kent, OH, USA.

Efforts to decrease the risk of overweight and obesity should focus on children's physical activity (PA) and fruit and vegetable (FV) consumption. Within school-based interventions, there is insufficient evidence on the effectiveness of the use of character modeling and goal setting to determine changes in step counts, MVPA, and FV consumption. Study participants were 187 students in grades 4 and 5 from 2 Title 1 elementary schools in the Southwest United States. Read More

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http://dx.doi.org/10.1177/1179556518784296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055244PMC
June 2018
1 Read

Post-acute Care for Children and Youth in Texas, 2011-2014.

Clin Med Insights Pediatr 2017 30;11:1179556517711445. Epub 2017 May 30.

Department of Health Policy & Management, School of Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, TX, USA.

Little is known about services provided to children and youth (C/Y) discharged from an acute care facility. Recent research has provided a foundation for efforts to supplement or complement that early work. This research investigates post-acute care (PAC) in Texas. Read More

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http://dx.doi.org/10.1177/1179556517711445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965663PMC
May 2017
2 Reads

Perceptions of Acute Malnutrition and Its Management in Infants Under 6 Months of Age: A Qualitative Study in Rural Bangladesh.

Clin Med Insights Pediatr 2018 3;12:1179556518771698. Epub 2018 May 3.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: World Health Organization guidelines advise community-based care (CBC) for "uncomplicated" severe acute malnutrition (SAM) infants <6 months old (u6m), whereas current national protocols refer to inpatient care. Our aim was to inform and shape future management strategies by understanding caregivers' and different stakeholders' perceptions on malnutrition among infants u6m on barriers/facilitators to future CBC.

Methods: The methods used in this study are as follows: in-depth interviews and focus group discussions (FGDs) in southern Bangladesh, thematic analysis of transcripts, and sample size by data saturation. Read More

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http://dx.doi.org/10.1177/1179556518771698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946588PMC
May 2018
10 Reads

A Review of the Factors Associated With the Timely Initiation of Breastfeeding and Exclusive Breastfeeding in the Middle East.

Authors:
Riyadh A Alzaheb

Clin Med Insights Pediatr 2017 17;11:1179556517748912. Epub 2017 Dec 17.

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Background: Breastfeeding supplies all the nutrients that infants need for their healthy development. Breastfeeding practice is multifactorial, and numerous variables influence mothers' decisions and ability to breastfeed. This review identifies the factors potentially affecting the timely initiation of breastfeeding within an hour after birth and exclusive breastfeeding in the first 6 months in Middle Eastern countries. Read More

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http://dx.doi.org/10.1177/1179556517748912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753894PMC
December 2017
5 Reads

Hypoglycemia: When to Treat?

Clin Med Insights Pediatr 2017 15;11:1179556517748913. Epub 2017 Dec 15.

Department of Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Hypoglycemia is the most common metabolic disorder encountered in neonates. The definition of hypoglycemia as well as its clinical significance and management remain controversial. Most cases of neonatal hypoglycemia are transient, respond readily to treatment, and are associated with an excellent prognosis. Read More

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http://dx.doi.org/10.1177/1179556517748913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734558PMC
December 2017
14 Reads

Incidence and Predictors of Mortality Among Newborns With Perinatal Asphyxia: A 4-Year Prospective Study of Newborns Delivered in Health Care Facilities in Enugu, South-East Nigeria.

Clin Med Insights Pediatr 2017 10;11:1179556517746646. Epub 2017 Dec 10.

Department of Paediatrics, Enugu State University of Science and Technology, Enugu, Nigeria.

Fatalities from perinatal asphyxia remain high in developing countries, and continually assessing its risk factors will help improve outcomes in these settings. We explored how some identified risk factors predict mortality in asphyxiated newborns, to assist clinicians in prioritizing interventions. This was a 4-year prospective study conducted at the Enugu State University Teaching Hospital, Enugu, Nigeria. Read More

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http://journals.sagepub.com/doi/10.1177/1179556517746646
Publisher Site
http://dx.doi.org/10.1177/1179556517746646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734560PMC
December 2017
25 Reads

Oral Immunotherapy With Partially Hydrolyzed Wheat-Based Cereals: A Pilot Study.

Clin Med Insights Pediatr 2017 8;11:1179556517730018. Epub 2017 Sep 8.

Allergy Group, Nutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland.

To date, only few studies have assessed oral immunotherapy (OIT) for wheat allergy and often describe severe adverse reactions during therapy. We developed partially hydrolyzed wheat-based cereals (pHC), which were used in a multicenter, open-label, OIT pilot study, in immunoglobulin E-mediated wheat allergy children (NCT01332084). The primary objective of the study was to test whether wheat allergic patients tolerate pHC and primary end point was the presence or not of immediate adverse reactions to pHC during the 1-day initial escalation phase (stepwise increased doses of pHC), with evaluation of the maximum dose tolerated. Read More

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http://dx.doi.org/10.1177/1179556517730018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593204PMC
September 2017
31 Reads

Novel insights into symptomatology of moyamoya disease in pediatric patients: survey of symptoms suggestive of orthostatic intolerance.

J Neurosurg Pediatr 2017 Nov 1;20(5):485-488. Epub 2017 Sep 1.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

OBJECTIVE A specific population of young patients with moyamoya disease (MMD) persistently experience physical symptoms not attributable to focal ischemia. These symptoms, highly suggestive of orthostatic intolerance (also termed "orthostatic dysregulation"), were investigated and reported as potential determinants of quality of life in young MMD patients. METHODS Forty-six patients (6-30 years of age) were selected from a group of 122 patients who were diagnosed with MMD before 18 years of age. Read More

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http://dx.doi.org/10.3171/2017.5.PEDS17198DOI Listing
November 2017
6 Reads

Spirometry in Asthma Care: A Review of the Trends and Challenges in Pediatric Practice.

Clin Med Insights Pediatr 2017 19;11:1179556517720675. Epub 2017 Jul 19.

Department of Pediatrics, Nyanya General Hospital, Abuja, Nigeria.

Background: Given the rising incidence of noncommunicable diseases (NCDs) globally, especially bronchial asthma, there is the need to reduce the associated morbidity and mortality by adopting an objective means of diagnosis and monitoring.

Aim: This article aims to review the trends and challenges in the use of spirometry for managing childhood bronchial asthma especially in developing countries.

Methods: We conducted a literature search of published data on the use of spirometry for the diagnosis of childhood bronchial asthma with special emphasis resource-poor countries. Read More

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http://dx.doi.org/10.1177/1179556517720675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521334PMC
July 2017
15 Reads

Parents' Assessments of Disability in Their Children Using World Health Organization International Classification of Functioning, Disability and Health, Child and Youth Version Joined Body Functions and Activity Codes Related to Everyday Life.

Clin Med Insights Pediatr 2017 19;11:1179556517715037. Epub 2017 Jun 19.

Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, South, Odense University Hospital, Odense, Denmark.

Aim: To help parents assess disability in their own children using World Health Organization (WHO) International Classification of Functioning, Disability and Health, Child and Youth Version (ICF-CY) code qualifier scoring and to assess the validity and reliability of the data sets obtained.

Method: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours performed scoring for 26 body functions qualifiers (b codes) and activities and participation qualifiers (d codes). Scoring was repeated after 6 months. Read More

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http://dx.doi.org/10.1177/1179556517715037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482351PMC
June 2017
8 Reads

Evaluation of Neonatal Transport in Western Switzerland: A Model of Perinatal Regionalization.

Clin Med Insights Pediatr 2017 17;11:1179556517709021. Epub 2017 May 17.

Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Neonatal transport is an essential part of regionalization for highly specialized neonatal intensive care. This retrospective analysis of prospectively collected data on neonatal transport activity in a large Swiss perinatal network more than 1 year, aimed to quantify this activity, to identify the needs for staff, and the demands regarding know-how and equipment. Of the 565 admissions to the tertiary neonatology clinic, 176 (31. Read More

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http://dx.doi.org/10.1177/1179556517709021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439992PMC
May 2017
12 Reads

Congenital Hepatic Cyst.

Clin Med Insights Pediatr 2017 10;11:1179556517702853. Epub 2017 Apr 10.

Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, NY, USA.

Congenital hepatic cyst is a rare and nonsymptomatic condition in infants and children. Its incidence is 2.5% in the postnatal life with a much lower incidence in the prenatal period. Read More

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http://dx.doi.org/10.1177/1179556517702853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398644PMC
April 2017
9 Reads

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections.

Clin Med Insights Pediatr 2017 30;11:1179556517701118. Epub 2017 Mar 30.

Division of Neonatology, Department of Pediatrics, Kecioren Education and Research Hospital, Ankara, Turkey.

Background And Purpose: Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (⩽10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out.

Patients And Methods: Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice. Newborns with a negative urine culture and with a positive urine culture were defined as group I and group II, respectively, and the 2 groups were compared with each other. Read More

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http://dx.doi.org/10.1177/1179556517701118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398657PMC
March 2017
16 Reads

Factors Influencing Exclusive Breastfeeding in Tabuk, Saudi Arabia.

Authors:
Riyadh A Alzaheb

Clin Med Insights Pediatr 2017 10;11:1179556517698136. Epub 2017 Mar 10.

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Background: Breast milk contains all the nutrients infants need for their first 6 months of life. However, only a minority of Saudi Arabian mothers exclusively breastfeed, so the influencing factors must be examined to encourage more to do so. The study aimed to determine the prevalence of exclusive breastfeeding at 6 months and its associated factors in Tabuk, North West Saudi Arabia. Read More

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http://dx.doi.org/10.1177/1179556517698136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398646PMC
March 2017
8 Reads

Relationship Between Exclusive Breastfeeding and Lower Risk of Childhood Obesity: A Narrative Review of Published Evidence.

Clin Med Insights Pediatr 2017 16;11:1179556517690196. Epub 2017 Feb 16.

Department of Pediatrics, Enugu State University Teaching Hospital, Enugu, Nigeria.

Background: The pattern of infant feeding during the first 1000-day period-from conception to the second birthday-has a significant influence on the child's growth trajectory. The relationship between exclusive breastfeeding and lower risk of childhood obesity has elicited much scientific interest, given the fact that this form of malnutrition is becoming a global epidemic.

Aim: This narrative review aims to examine the evidence in the literature linking exclusive breastfeeding with reduction in obesity in children. Read More

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http://dx.doi.org/10.1177/1179556517690196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398325PMC
February 2017
24 Reads

Early Benefits of a Starter Formula Enriched in Prebiotics and Probiotics on the Gut Microbiota of Healthy Infants Born to HIV+ Mothers: A Randomized Double-Blind Controlled Trial.

Clin Med Insights Pediatr 2016 8;10:119-130. Epub 2017 Jan 8.

Nestlé Health Science, Vevey, Switzerland.

The gut microbiota of infants is shaped by both the mode of delivery and the type of feeding. The gut of vaginally and cesarean-delivered infants is colonized at different rates and with different bacterial species, leading to differences in the gut microbial composition, which may persist up to 6 months. In a multicenter, randomized, controlled, double-blind trial conducted in South Africa, we tested the effect of a formula supplemented with a prebiotic (a mixture of bovine milk-derived oligosaccharides [BMOS] generated from whey permeate and containing galactooligosaccharides and milk oligosaccharides such as 3'- and 6'-sialyllactose) and the probiotic subsp. Read More

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http://dx.doi.org/10.4137/CMPed.S40134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221488PMC
January 2017
62 Reads

A Novel Homozygous Frameshift Mutation in Exon 2 of Gene Associated with Severe Obesity: A Case Report.

Clin Med Insights Pediatr 2016 11;10:115-118. Epub 2016 Dec 11.

Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Background: Monogenic obesity is a rare type of obesity caused by a mutation in a single gene. Patients with monogenic obesity may develop early onset of obesity and severe metabolic abnormalities.

Case Presentation: A two-and-half-year-old girl was presented to our clinic because of excessive weight gain and hyperphagia. Read More

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http://dx.doi.org/10.4137/CMPed.S40432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153319PMC
December 2016
13 Reads

Pediatric Weight Management Program Outcomes in a Largely Minority, Low Socioeconomic Status Population.

Clin Med Insights Pediatr 2016 5;10:109-114. Epub 2016 Dec 5.

Johns Hopkins Children's Center, Baltimore, MD, USA.

This article describes the outcomes of a pediatric weight management program for a population primarily composed of minority ethnic groups and those from a lower socioeconomic status group. As these groups are disproportionally affected by pediatric obesity and overweight complicated by higher rates of attrition and poorer response to intervention, it is important that adequate and effective treatment exists for patients in these groups. Further research is needed to analyze the outcomes and attrition in these high-risk populations. Read More

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http://dx.doi.org/10.4137/CMPed.S38457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140010PMC
December 2016
5 Reads

The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.

Clin Med Insights Pediatr 2016 9;10:91-107. Epub 2016 Oct 9.

Arkansas Children's Research Institute, Little Rock, AR, USA.; Division of Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Recent studies have highlighted the fact that the enteric microbiome, the trillions of microbes that inhabit the human digestive tract, has a significant effect on health and disease. Methods for manipulating the enteric microbiome, particularly through probiotics and microbial ecosystem transplantation, have undergone some study in clinical trials. We review some of the evidence for microbiome alteration in relation to childhood disease and discuss the clinical trials that have examined the manipulation of the microbiome in an effort to prevent or treat childhood disease with a primary focus on probiotics, prebiotics, and/or synbiotics (ie, probiotics + prebiotics). Read More

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http://dx.doi.org/10.4137/CMPed.S38338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063840PMC
October 2016
29 Reads

PREMM: preterm early massage by the mother: protocol of a randomised controlled trial of massage therapy in very preterm infants.

BMC Pediatr 2016 08 27;16(1):146. Epub 2016 Aug 27.

Perinatal Research Centre, School of Medicine, Royal Brisbane & Women's Hospital, Brisbane, Qld, Australia.

Background: Preterm infants follow an altered neurodevelopmental trajectory compared to their term born peers as a result of the influence of early birth, and the altered environment. Infant massage in the preterm infant has shown positive effects on weight gain and reduced length of hospital stay. There is however, limited current evidence of improved neurodevelopment or improved attachment, maternal mood or anxiety. Read More

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http://dx.doi.org/10.1186/s12887-016-0678-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002318PMC
August 2016
51 Reads

Serum Neutrophil Gelatinase-Associated Lipocalin in Infants and Children with Sepsis-Related Conditions with or without Acute Renal Dysfunction.

Clin Med Insights Pediatr 2016 8;10:85-9. Epub 2016 Aug 8.

Department of Clinical Pathology, Faculty of Medicine, Minia University Hospital, Minia, Egypt.

Purpose: To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury (AKI) in sepsis-related conditions and its predictive and prognostic values.

Patients And Methods: This study included 65 patients, who were clinically evaluated for sepsis, severe sepsis, or septic shock, and 20 apparently healthy served as controls. Patients were divided into two groups: Group I (AKI-sepsis): 65 newly admitted patients diagnosed as sepsis, who were further divided into three subgroups according to the severity: systemic inflammatory response syndrome, severe sepsis, and septic shock, and Group II (control group): 20 apparently healthy subjects matched for age and sex, serum creatinine and serum NGAL concentrations were estimated initially within 24 hours of admission and after 72 hours of admission in all patients and control groups. Read More

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http://dx.doi.org/10.4137/CMPed.S39452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978195PMC
August 2016
5 Reads

Intrauterine Growth Restriction: Antenatal and Postnatal Aspects.

Clin Med Insights Pediatr 2016 14;10:67-83. Epub 2016 Jul 14.

Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Jaipur, Rajasthan, India.

Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. Read More

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http://dx.doi.org/10.4137/CMPed.S40070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946587PMC
July 2016
25 Reads

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation.

Clin Med Insights Pediatr 2016 12;10:57-65. Epub 2016 Jul 12.

Department of Pediatrics, Oregon Health and Science University, Doernbecher Children's Hospital, Portland, OR, USA.

Cystic fibrosis (CF) is a chronic disorder characterized by acute pulmonary exacerbations that comprise increased cough, chest congestion, increased mucus production, shortness of breath, weight loss, and fatigue. Typically, severe episodes are treated in the inpatient setting and include intravenous antimicrobials, airway clearance therapy, and nutritional support. Children with less-severe findings can often be managed as outpatients with oral antimicrobials and increased airway clearance therapy at home without visiting the specialty CF center to begin treatment. Read More

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http://dx.doi.org/10.4137/CMPed.S38336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944828PMC
July 2016
5 Reads

Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes.

Clin Med Insights Pediatr 2016 15;10:43-56. Epub 2016 Jun 15.

Rossignol Medical Center, Irvine CA, USA.

Despite the fact that the prevalence of autism spectrum disorder (ASD) continues to rise, no effective medical treatments have become standard of care. In this paper we review some of the pathophysiological abnormalities associated with ASD and their potential associated treatments. Overall, there is evidence for some children with ASD being affected by seizure and epilepsy, neurotransmitter dysfunction, sleep disorders, metabolic abnormalities, including abnormalities in folate, cobalamin, tetrahydrobiopterin, carnitine, redox and mitochondrial metabolism, and immune and gastrointestinal disorders. Read More

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http://dx.doi.org/10.4137/CMPed.S38337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910649PMC
June 2016
7 Reads

Universal Pulse Oximetry Screening for Early Detection of Critical Congenital Heart Disease.

Authors:
Praveen Kumar

Clin Med Insights Pediatr 2016 1;10:35-41. Epub 2016 Jun 1.

Associate Chair, Visiting Professor of Pediatrics, Department of Pediatrics, University of Illinois, Children's Hospital of Illinois, Peoria, IL, USA.

Critical congenital heart disease (CCHD) is a major cause of infant death and morbidity worldwide. An early diagnosis and timely intervention can significantly reduce the likelihood of an adverse outcome. However, studies from the United States and other developed countries have shown that as many as 30%-50% of infants with CCHD are discharged after birth without being identified. Read More

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http://dx.doi.org/10.4137/CMPed.S33086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892233PMC
June 2016
6 Reads

Correlation of Apgar Score with Asphyxial Hepatic Injury and Mortality in Newborns: A Prospective Observational Study From India.

Clin Med Insights Pediatr 2016 10;10:27-34. Epub 2016 May 10.

Department of Pathology, N.K.P. Salve Medical College, Nagpur, Maharashtra, India.

Objective: The objective of this study is to determine the correlation of Apgar score with asphyxial hepatic injury and neonatal mortality in moderately and severely asphyxiated newborns.

Material And Methods: This is a secondary analysis of our prospective observational case-controlled study. Sixteen neonates with severe birth asphyxia (five-minute Apgar ≤3) were compared with either 54 moderate asphyxia neonates (five-minute Apgar >3) or 30 normal neonates. Read More

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http://dx.doi.org/10.4137/CMPed.S38503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863868PMC
May 2016
7 Reads

Hemophagocytic Lymphohistiocytosis: Single-Center Series of 12 Cases from Saudi Arabia.

Clin Med Insights Pediatr 2016 5;10:21-6. Epub 2016 Apr 5.

Department of Pediatric Hematology/Oncology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease that commonly appears in infancy, although it has been reported in adults. Chemoimmunotherapy-based treatments have improved the survival of patients with HLH; however, overall survival is still poor. We retrospectively analyzed the data of 12 HLH patients who were admitted between 2005 and 2014. Read More

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http://dx.doi.org/10.4137/CMPed.S35853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822721PMC
April 2016
41 Reads

Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study.

Clin Med Insights Pediatr 2016 13;10:11-9. Epub 2016 Mar 13.

Neonatal Department, Alexandra Hospital, University of Athens, Greece.

Background: In the absence of breast-feeding and its immunomodulatory factors, supplementation of starter infant formula (IF) with probiotics is currently used to support immune functions and gut development.

Aim: To assess whether immune-related beneficial effects of regular dose (10(7) CFU/g of powder) of the probiotic Bifidobacterium lactis CNCM I-3446 (hereafter named B. lactis) in starter IF supplementation can be maintained with starter IF containing a low dose (10(4) CFU/g of powder) of B. Read More

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http://dx.doi.org/10.4137/CMPed.S33096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792197PMC
March 2016
9 Reads

Assessment of Growth of Infants Fed an Amino Acid-Based Formula.

Clin Med Insights Pediatr 2016 4;10:3-9. Epub 2016 Feb 4.

Nestlé Nutrition, Vevey, Switzerland.

Objective: This study's primary aim was to compare the growth (daily weight gain) of infants consuming a new (Test) amino acid-based formula (AAF) or a commercially available AAF (Control).

Methods: Healthy infants were randomized to Test or Control from 14 to 112 days of age. Anthropometric measurements were taken at 14, 28, 56, 84, and 112 days of age. Read More

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http://dx.doi.org/10.4137/CMPed.S33071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743746PMC
February 2016
6 Reads

Notice of Redundant Publication.

Authors:
Praveen Kumar

Clin Med Insights Pediatr 2016 13;10. Epub 2016 Jan 13.

Editor in Chief, Clinical Medicine Insights: Pediatrics.

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http://dx.doi.org/10.4137/CMPed.S38236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741187PMC
February 2016
5 Reads

An Overview of Iron in Term Breast-Fed Infants.

Clin Med Insights Pediatr 2015 23;9:79-84. Epub 2015 Sep 23.

Department of Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.

Background: Iron is an essential nutrient for normal growth and neurodevelopment of infants. Iron deficiency (ID) remains the most common micronutrient deficiency worldwide. There are convincing data that ID is associated with negative effects on neurological and psychomotor development. Read More

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http://dx.doi.org/10.4137/CMPed.S26572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583094PMC
October 2015
7 Reads

Pattern of Adverse Drug Reactions in Children Attending the Department of Pediatrics in a Tertiary Care Center: A Prospective Observational Study.

Clin Med Insights Pediatr 2015 11;9:73-8. Epub 2015 Aug 11.

Department of Pediatrics, SMGS hospital, Jammu, India.

Aim: To study the pattern of various adverse drug reactions (ADRs) occurring in children attending the Department of Pediatrics, SMGS Hospital, Jammu over 1 year.

Subjects And Methods: This was a prospective study, with study population of patients attending Department of Pediatrics over a period of 1 year. A structured format was used to enroll the participants. Read More

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http://dx.doi.org/10.4137/CMPed.S29493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533849PMC
August 2015
6 Reads

Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease.

Clin Med Insights Pediatr 2015 9;9:67-72. Epub 2015 Aug 9.

Pediatric Department, Royal Medical Services, Amman, Jordan.

Objective: The objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates.

Patients And Method: This single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97). Read More

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http://dx.doi.org/10.4137/CMPed.S24909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531018PMC
August 2015
7 Reads

A unique phenotype in a patient with a rare triplication of the 22q11.2 region and new clinical insights of the 22q11.2 microduplication syndrome: a report of two cases.

BMC Pediatr 2015 Aug 22;15:95. Epub 2015 Aug 22.

Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPE, Av. D. Manuel I, 9500-370, Ponta Delgada, São Miguel Island, Azores, Portugal.

Background: The rearrangements of the 22q11.2 chromosomal region, most frequently deletions and duplications, have been known to be responsible for multiple congenital anomaly disorders. These rearrangements are implicated in syndromes that have some phenotypic resemblances. Read More

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http://dx.doi.org/10.1186/s12887-015-0417-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546098PMC
August 2015
23 Reads
5 Citations
1.920 Impact Factor

Presentation of a Clitoral Mass in a Prepubescent Female: A Case Report and Discussion of the Evaluation.

Clin Med Insights Pediatr 2015 23;9:65-6. Epub 2015 Jun 23.

Division of Pediatric Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Clitoral masses are rare. We present a case report of a prepubescent female with a periclitoral mass. Read More

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http://dx.doi.org/10.4137/CMPed.S24535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479168PMC
June 2015
6 Reads

The effects of celecoxib or naproxen on blood pressure in pediatric patients with juvenile idiopathic arthritis.

Clin Med Insights Pediatr 2015 4;9:55-62. Epub 2015 May 4.

Connecticut Children's Medical Center, Hartford, CT, USA.

Background: Selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are indicated for the treatment of juvenile idiopathic arthritis (JIA). However, the effect of NSAIDs on blood pressure (BP) in children has not been rigorously examined.

Methods: In this randomized, double-blind, multicenter, active-controlled, 6-week trial, the safety and efficacy of celecoxib (50 mg twice daily [bid] or 100 mg bid) or naproxen (7. Read More

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http://dx.doi.org/10.4137/CMPed.s20720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425196PMC
May 2015
12 Reads