88 results match your criteria Clinical Medicine Insights: Pediatrics [Journal]


Parents' Expressions of Concerns and Hopes for the Future and Their Concomitant Assessments of Disability in Their Children.

Clin Med Insights Pediatr 2018 27;12:1179556518784948. Epub 2018 Jun 27.

Center for Clinical Epidemiology, Research Unit of Clinical Epidemiology, Odense University Hospital, Odense, Denmark.

Aim: To assess parents' ability to express their concerns and hopes for the future in their children with disability and assess their children's disability as well as to analyse these data for consistency.

Method: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours were asked to freely express their concerns and hopes for the future and to assess disability in their own children by employing a set of 26 International Classification of Functioning, Disability and Health, Children and Youth Version (ICF-CY) body function (b) codes and activity and participation (d) codes. A grounded theory approach was employed to systematize parents' expressions of concerns and hopes; then, parents scored qualifiers on a 5-step qualitative Likert scale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556518784948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055242PMC
June 2018
9 Reads

Factors Associated with Prescribing Broad-Spectrum Antibiotics for Children with Upper Respiratory Tract Infections in Ambulatory Care Settings.

Clin Med Insights Pediatr 2018 2;12:1179556518784300. Epub 2018 Jul 2.

Department of Clinical and Administrative Pharmacy Sciences, Howard University, Washington, DC, USA.

Objectives: Broad-spectrum antibiotics are frequently prescribed for children with upper respiratory tract infections (URI). Excessive use of broad-spectrum antibiotics leads to the emergence of resistant bacteria. This study aimed to identify factors associated with prescribing broad-spectrum antibiotics among children younger than 18 years presenting with URI in outpatient settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556518784300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055249PMC
July 2018
14 Reads

Fit "N" Cool Kids: The Effects of Character Modeling and Goal Setting on Children's Physical Activity and Fruit and Vegetable Consumption.

Clin Med Insights Pediatr 2018 25;12:1179556518784296. Epub 2018 Jun 25.

College of Education, Health and Human Services, Kent State University, Kent, OH, USA.

Efforts to decrease the risk of overweight and obesity should focus on children's physical activity (PA) and fruit and vegetable (FV) consumption. Within school-based interventions, there is insufficient evidence on the effectiveness of the use of character modeling and goal setting to determine changes in step counts, MVPA, and FV consumption. Study participants were 187 students in grades 4 and 5 from 2 Title 1 elementary schools in the Southwest United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556518784296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055244PMC

Post-acute Care for Children and Youth in Texas, 2011-2014.

Clin Med Insights Pediatr 2017 30;11:1179556517711445. Epub 2017 May 30.

Department of Health Policy & Management, School of Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, TX, USA.

Little is known about services provided to children and youth (C/Y) discharged from an acute care facility. Recent research has provided a foundation for efforts to supplement or complement that early work. This research investigates post-acute care (PAC) in Texas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517711445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965663PMC
May 2017
1 Read

Perceptions of Acute Malnutrition and Its Management in Infants Under 6 Months of Age: A Qualitative Study in Rural Bangladesh.

Clin Med Insights Pediatr 2018 3;12:1179556518771698. Epub 2018 May 3.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: World Health Organization guidelines advise community-based care (CBC) for "uncomplicated" severe acute malnutrition (SAM) infants <6 months old (u6m), whereas current national protocols refer to inpatient care. Our aim was to inform and shape future management strategies by understanding caregivers' and different stakeholders' perceptions on malnutrition among infants u6m on barriers/facilitators to future CBC.

Methods: The methods used in this study are as follows: in-depth interviews and focus group discussions (FGDs) in southern Bangladesh, thematic analysis of transcripts, and sample size by data saturation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556518771698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946588PMC
May 2018
6 Reads

A Review of the Factors Associated With the Timely Initiation of Breastfeeding and Exclusive Breastfeeding in the Middle East.

Authors:
Riyadh A Alzaheb

Clin Med Insights Pediatr 2017 17;11:1179556517748912. Epub 2017 Dec 17.

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Background: Breastfeeding supplies all the nutrients that infants need for their healthy development. Breastfeeding practice is multifactorial, and numerous variables influence mothers' decisions and ability to breastfeed. This review identifies the factors potentially affecting the timely initiation of breastfeeding within an hour after birth and exclusive breastfeeding in the first 6 months in Middle Eastern countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517748912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753894PMC
December 2017
4 Reads

Hypoglycemia: When to Treat?

Clin Med Insights Pediatr 2017 15;11:1179556517748913. Epub 2017 Dec 15.

Department of Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Hypoglycemia is the most common metabolic disorder encountered in neonates. The definition of hypoglycemia as well as its clinical significance and management remain controversial. Most cases of neonatal hypoglycemia are transient, respond readily to treatment, and are associated with an excellent prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517748913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734558PMC
December 2017
13 Reads

Incidence and Predictors of Mortality Among Newborns With Perinatal Asphyxia: A 4-Year Prospective Study of Newborns Delivered in Health Care Facilities in Enugu, South-East Nigeria.

Clin Med Insights Pediatr 2017 10;11:1179556517746646. Epub 2017 Dec 10.

Department of Paediatrics, Enugu State University of Science and Technology, Enugu, Nigeria.

Fatalities from perinatal asphyxia remain high in developing countries, and continually assessing its risk factors will help improve outcomes in these settings. We explored how some identified risk factors predict mortality in asphyxiated newborns, to assist clinicians in prioritizing interventions. This was a 4-year prospective study conducted at the Enugu State University Teaching Hospital, Enugu, Nigeria. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1179556517746646
Publisher Site
http://dx.doi.org/10.1177/1179556517746646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734560PMC
December 2017
20 Reads

Oral Immunotherapy With Partially Hydrolyzed Wheat-Based Cereals: A Pilot Study.

Clin Med Insights Pediatr 2017 8;11:1179556517730018. Epub 2017 Sep 8.

Allergy Group, Nutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland.

To date, only few studies have assessed oral immunotherapy (OIT) for wheat allergy and often describe severe adverse reactions during therapy. We developed partially hydrolyzed wheat-based cereals (pHC), which were used in a multicenter, open-label, OIT pilot study, in immunoglobulin E-mediated wheat allergy children (NCT01332084). The primary objective of the study was to test whether wheat allergic patients tolerate pHC and primary end point was the presence or not of immediate adverse reactions to pHC during the 1-day initial escalation phase (stepwise increased doses of pHC), with evaluation of the maximum dose tolerated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517730018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593204PMC
September 2017
22 Reads

Novel insights into symptomatology of moyamoya disease in pediatric patients: survey of symptoms suggestive of orthostatic intolerance.

J Neurosurg Pediatr 2017 Nov 1;20(5):485-488. Epub 2017 Sep 1.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

OBJECTIVE A specific population of young patients with moyamoya disease (MMD) persistently experience physical symptoms not attributable to focal ischemia. These symptoms, highly suggestive of orthostatic intolerance (also termed "orthostatic dysregulation"), were investigated and reported as potential determinants of quality of life in young MMD patients. METHODS Forty-six patients (6-30 years of age) were selected from a group of 122 patients who were diagnosed with MMD before 18 years of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2017.5.PEDS17198DOI Listing
November 2017
5 Reads

Spirometry in Asthma Care: A Review of the Trends and Challenges in Pediatric Practice.

Clin Med Insights Pediatr 2017 19;11:1179556517720675. Epub 2017 Jul 19.

Department of Pediatrics, Nyanya General Hospital, Abuja, Nigeria.

Background: Given the rising incidence of noncommunicable diseases (NCDs) globally, especially bronchial asthma, there is the need to reduce the associated morbidity and mortality by adopting an objective means of diagnosis and monitoring.

Aim: This article aims to review the trends and challenges in the use of spirometry for managing childhood bronchial asthma especially in developing countries.

Methods: We conducted a literature search of published data on the use of spirometry for the diagnosis of childhood bronchial asthma with special emphasis resource-poor countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517720675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521334PMC
July 2017
11 Reads

Parents' Assessments of Disability in Their Children Using World Health Organization International Classification of Functioning, Disability and Health, Child and Youth Version Joined Body Functions and Activity Codes Related to Everyday Life.

Clin Med Insights Pediatr 2017 19;11:1179556517715037. Epub 2017 Jun 19.

Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, South, Odense University Hospital, Odense, Denmark.

Aim: To help parents assess disability in their own children using World Health Organization (WHO) International Classification of Functioning, Disability and Health, Child and Youth Version (ICF-CY) code qualifier scoring and to assess the validity and reliability of the data sets obtained.

Method: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours performed scoring for 26 body functions qualifiers (b codes) and activities and participation qualifiers (d codes). Scoring was repeated after 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517715037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482351PMC
June 2017
7 Reads

Evaluation of Neonatal Transport in Western Switzerland: A Model of Perinatal Regionalization.

Clin Med Insights Pediatr 2017 17;11:1179556517709021. Epub 2017 May 17.

Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Neonatal transport is an essential part of regionalization for highly specialized neonatal intensive care. This retrospective analysis of prospectively collected data on neonatal transport activity in a large Swiss perinatal network more than 1 year, aimed to quantify this activity, to identify the needs for staff, and the demands regarding know-how and equipment. Of the 565 admissions to the tertiary neonatology clinic, 176 (31. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517709021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439992PMC
May 2017
11 Reads

Congenital Hepatic Cyst.

Clin Med Insights Pediatr 2017 10;11:1179556517702853. Epub 2017 Apr 10.

Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, NY, USA.

Congenital hepatic cyst is a rare and nonsymptomatic condition in infants and children. Its incidence is 2.5% in the postnatal life with a much lower incidence in the prenatal period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517702853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398644PMC
April 2017
7 Reads

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections.

Clin Med Insights Pediatr 2017 30;11:1179556517701118. Epub 2017 Mar 30.

Division of Neonatology, Department of Pediatrics, Kecioren Education and Research Hospital, Ankara, Turkey.

Background And Purpose: Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (⩽10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out.

Patients And Methods: Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice. Newborns with a negative urine culture and with a positive urine culture were defined as group I and group II, respectively, and the 2 groups were compared with each other. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517701118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398657PMC
March 2017
14 Reads

Factors Influencing Exclusive Breastfeeding in Tabuk, Saudi Arabia.

Authors:
Riyadh A Alzaheb

Clin Med Insights Pediatr 2017 10;11:1179556517698136. Epub 2017 Mar 10.

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Background: Breast milk contains all the nutrients infants need for their first 6 months of life. However, only a minority of Saudi Arabian mothers exclusively breastfeed, so the influencing factors must be examined to encourage more to do so. The study aimed to determine the prevalence of exclusive breastfeeding at 6 months and its associated factors in Tabuk, North West Saudi Arabia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517698136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398646PMC
March 2017
7 Reads

Relationship Between Exclusive Breastfeeding and Lower Risk of Childhood Obesity: A Narrative Review of Published Evidence.

Clin Med Insights Pediatr 2017 16;11:1179556517690196. Epub 2017 Feb 16.

Department of Pediatrics, Enugu State University Teaching Hospital, Enugu, Nigeria.

Background: The pattern of infant feeding during the first 1000-day period-from conception to the second birthday-has a significant influence on the child's growth trajectory. The relationship between exclusive breastfeeding and lower risk of childhood obesity has elicited much scientific interest, given the fact that this form of malnutrition is becoming a global epidemic.

Aim: This narrative review aims to examine the evidence in the literature linking exclusive breastfeeding with reduction in obesity in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179556517690196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398325PMC
February 2017
21 Reads

Early Benefits of a Starter Formula Enriched in Prebiotics and Probiotics on the Gut Microbiota of Healthy Infants Born to HIV+ Mothers: A Randomized Double-Blind Controlled Trial.

Clin Med Insights Pediatr 2016 8;10:119-130. Epub 2017 Jan 8.

Nestlé Health Science, Vevey, Switzerland.

The gut microbiota of infants is shaped by both the mode of delivery and the type of feeding. The gut of vaginally and cesarean-delivered infants is colonized at different rates and with different bacterial species, leading to differences in the gut microbial composition, which may persist up to 6 months. In a multicenter, randomized, controlled, double-blind trial conducted in South Africa, we tested the effect of a formula supplemented with a prebiotic (a mixture of bovine milk-derived oligosaccharides [BMOS] generated from whey permeate and containing galactooligosaccharides and milk oligosaccharides such as 3'- and 6'-sialyllactose) and the probiotic subsp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S40134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221488PMC
January 2017
38 Reads

A Novel Homozygous Frameshift Mutation in Exon 2 of Gene Associated with Severe Obesity: A Case Report.

Clin Med Insights Pediatr 2016 11;10:115-118. Epub 2016 Dec 11.

Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Background: Monogenic obesity is a rare type of obesity caused by a mutation in a single gene. Patients with monogenic obesity may develop early onset of obesity and severe metabolic abnormalities.

Case Presentation: A two-and-half-year-old girl was presented to our clinic because of excessive weight gain and hyperphagia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S40432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153319PMC
December 2016
7 Reads

Pediatric Weight Management Program Outcomes in a Largely Minority, Low Socioeconomic Status Population.

Clin Med Insights Pediatr 2016 5;10:109-114. Epub 2016 Dec 5.

Johns Hopkins Children's Center, Baltimore, MD, USA.

This article describes the outcomes of a pediatric weight management program for a population primarily composed of minority ethnic groups and those from a lower socioeconomic status group. As these groups are disproportionally affected by pediatric obesity and overweight complicated by higher rates of attrition and poorer response to intervention, it is important that adequate and effective treatment exists for patients in these groups. Further research is needed to analyze the outcomes and attrition in these high-risk populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140010PMC
December 2016
4 Reads

The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.

Clin Med Insights Pediatr 2016 9;10:91-107. Epub 2016 Oct 9.

Arkansas Children's Research Institute, Little Rock, AR, USA.; Division of Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Recent studies have highlighted the fact that the enteric microbiome, the trillions of microbes that inhabit the human digestive tract, has a significant effect on health and disease. Methods for manipulating the enteric microbiome, particularly through probiotics and microbial ecosystem transplantation, have undergone some study in clinical trials. We review some of the evidence for microbiome alteration in relation to childhood disease and discuss the clinical trials that have examined the manipulation of the microbiome in an effort to prevent or treat childhood disease with a primary focus on probiotics, prebiotics, and/or synbiotics (ie, probiotics + prebiotics). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063840PMC
October 2016
21 Reads

PREMM: preterm early massage by the mother: protocol of a randomised controlled trial of massage therapy in very preterm infants.

BMC Pediatr 2016 08 27;16(1):146. Epub 2016 Aug 27.

Perinatal Research Centre, School of Medicine, Royal Brisbane & Women's Hospital, Brisbane, Qld, Australia.

Background: Preterm infants follow an altered neurodevelopmental trajectory compared to their term born peers as a result of the influence of early birth, and the altered environment. Infant massage in the preterm infant has shown positive effects on weight gain and reduced length of hospital stay. There is however, limited current evidence of improved neurodevelopment or improved attachment, maternal mood or anxiety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-016-0678-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002318PMC
August 2016
29 Reads

Serum Neutrophil Gelatinase-Associated Lipocalin in Infants and Children with Sepsis-Related Conditions with or without Acute Renal Dysfunction.

Clin Med Insights Pediatr 2016 8;10:85-9. Epub 2016 Aug 8.

Department of Clinical Pathology, Faculty of Medicine, Minia University Hospital, Minia, Egypt.

Purpose: To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury (AKI) in sepsis-related conditions and its predictive and prognostic values.

Patients And Methods: This study included 65 patients, who were clinically evaluated for sepsis, severe sepsis, or septic shock, and 20 apparently healthy served as controls. Patients were divided into two groups: Group I (AKI-sepsis): 65 newly admitted patients diagnosed as sepsis, who were further divided into three subgroups according to the severity: systemic inflammatory response syndrome, severe sepsis, and septic shock, and Group II (control group): 20 apparently healthy subjects matched for age and sex, serum creatinine and serum NGAL concentrations were estimated initially within 24 hours of admission and after 72 hours of admission in all patients and control groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S39452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978195PMC
August 2016
4 Reads

Intrauterine Growth Restriction: Antenatal and Postnatal Aspects.

Clin Med Insights Pediatr 2016 14;10:67-83. Epub 2016 Jul 14.

Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Jaipur, Rajasthan, India.

Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S40070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946587PMC
July 2016
20 Reads

One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation.

Clin Med Insights Pediatr 2016 12;10:57-65. Epub 2016 Jul 12.

Department of Pediatrics, Oregon Health and Science University, Doernbecher Children's Hospital, Portland, OR, USA.

Cystic fibrosis (CF) is a chronic disorder characterized by acute pulmonary exacerbations that comprise increased cough, chest congestion, increased mucus production, shortness of breath, weight loss, and fatigue. Typically, severe episodes are treated in the inpatient setting and include intravenous antimicrobials, airway clearance therapy, and nutritional support. Children with less-severe findings can often be managed as outpatients with oral antimicrobials and increased airway clearance therapy at home without visiting the specialty CF center to begin treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944828PMC
July 2016
4 Reads

Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes.

Clin Med Insights Pediatr 2016 15;10:43-56. Epub 2016 Jun 15.

Rossignol Medical Center, Irvine CA, USA.

Despite the fact that the prevalence of autism spectrum disorder (ASD) continues to rise, no effective medical treatments have become standard of care. In this paper we review some of the pathophysiological abnormalities associated with ASD and their potential associated treatments. Overall, there is evidence for some children with ASD being affected by seizure and epilepsy, neurotransmitter dysfunction, sleep disorders, metabolic abnormalities, including abnormalities in folate, cobalamin, tetrahydrobiopterin, carnitine, redox and mitochondrial metabolism, and immune and gastrointestinal disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910649PMC
June 2016
6 Reads

Universal Pulse Oximetry Screening for Early Detection of Critical Congenital Heart Disease.

Authors:
Praveen Kumar

Clin Med Insights Pediatr 2016 1;10:35-41. Epub 2016 Jun 1.

Associate Chair, Visiting Professor of Pediatrics, Department of Pediatrics, University of Illinois, Children's Hospital of Illinois, Peoria, IL, USA.

Critical congenital heart disease (CCHD) is a major cause of infant death and morbidity worldwide. An early diagnosis and timely intervention can significantly reduce the likelihood of an adverse outcome. However, studies from the United States and other developed countries have shown that as many as 30%-50% of infants with CCHD are discharged after birth without being identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S33086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892233PMC
June 2016
5 Reads

Correlation of Apgar Score with Asphyxial Hepatic Injury and Mortality in Newborns: A Prospective Observational Study From India.

Clin Med Insights Pediatr 2016 10;10:27-34. Epub 2016 May 10.

Department of Pathology, N.K.P. Salve Medical College, Nagpur, Maharashtra, India.

Objective: The objective of this study is to determine the correlation of Apgar score with asphyxial hepatic injury and neonatal mortality in moderately and severely asphyxiated newborns.

Material And Methods: This is a secondary analysis of our prospective observational case-controlled study. Sixteen neonates with severe birth asphyxia (five-minute Apgar ≤3) were compared with either 54 moderate asphyxia neonates (five-minute Apgar >3) or 30 normal neonates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863868PMC
May 2016
6 Reads

Hemophagocytic Lymphohistiocytosis: Single-Center Series of 12 Cases from Saudi Arabia.

Clin Med Insights Pediatr 2016 5;10:21-6. Epub 2016 Apr 5.

Department of Pediatric Hematology/Oncology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease that commonly appears in infancy, although it has been reported in adults. Chemoimmunotherapy-based treatments have improved the survival of patients with HLH; however, overall survival is still poor. We retrospectively analyzed the data of 12 HLH patients who were admitted between 2005 and 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S35853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822721PMC
April 2016
31 Reads

Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study.

Clin Med Insights Pediatr 2016 13;10:11-9. Epub 2016 Mar 13.

Neonatal Department, Alexandra Hospital, University of Athens, Greece.

Background: In the absence of breast-feeding and its immunomodulatory factors, supplementation of starter infant formula (IF) with probiotics is currently used to support immune functions and gut development.

Aim: To assess whether immune-related beneficial effects of regular dose (10(7) CFU/g of powder) of the probiotic Bifidobacterium lactis CNCM I-3446 (hereafter named B. lactis) in starter IF supplementation can be maintained with starter IF containing a low dose (10(4) CFU/g of powder) of B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S33096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792197PMC
March 2016
8 Reads

Assessment of Growth of Infants Fed an Amino Acid-Based Formula.

Clin Med Insights Pediatr 2016 4;10:3-9. Epub 2016 Feb 4.

Nestlé Nutrition, Vevey, Switzerland.

Objective: This study's primary aim was to compare the growth (daily weight gain) of infants consuming a new (Test) amino acid-based formula (AAF) or a commercially available AAF (Control).

Methods: Healthy infants were randomized to Test or Control from 14 to 112 days of age. Anthropometric measurements were taken at 14, 28, 56, 84, and 112 days of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S33071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743746PMC
February 2016
5 Reads

Notice of Redundant Publication.

Authors:
Praveen Kumar

Clin Med Insights Pediatr 2016 13;10. Epub 2016 Jan 13.

Editor in Chief, Clinical Medicine Insights: Pediatrics.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S38236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741187PMC
February 2016
4 Reads

An Overview of Iron in Term Breast-Fed Infants.

Clin Med Insights Pediatr 2015 23;9:79-84. Epub 2015 Sep 23.

Department of Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.

Background: Iron is an essential nutrient for normal growth and neurodevelopment of infants. Iron deficiency (ID) remains the most common micronutrient deficiency worldwide. There are convincing data that ID is associated with negative effects on neurological and psychomotor development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S26572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583094PMC
October 2015
6 Reads

Pattern of Adverse Drug Reactions in Children Attending the Department of Pediatrics in a Tertiary Care Center: A Prospective Observational Study.

Clin Med Insights Pediatr 2015 11;9:73-8. Epub 2015 Aug 11.

Department of Pediatrics, SMGS hospital, Jammu, India.

Aim: To study the pattern of various adverse drug reactions (ADRs) occurring in children attending the Department of Pediatrics, SMGS Hospital, Jammu over 1 year.

Subjects And Methods: This was a prospective study, with study population of patients attending Department of Pediatrics over a period of 1 year. A structured format was used to enroll the participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S29493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533849PMC
August 2015
4 Reads

Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease.

Clin Med Insights Pediatr 2015 9;9:67-72. Epub 2015 Aug 9.

Pediatric Department, Royal Medical Services, Amman, Jordan.

Objective: The objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates.

Patients And Method: This single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S24909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531018PMC
August 2015
6 Reads

A unique phenotype in a patient with a rare triplication of the 22q11.2 region and new clinical insights of the 22q11.2 microduplication syndrome: a report of two cases.

BMC Pediatr 2015 Aug 22;15:95. Epub 2015 Aug 22.

Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPE, Av. D. Manuel I, 9500-370, Ponta Delgada, São Miguel Island, Azores, Portugal.

Background: The rearrangements of the 22q11.2 chromosomal region, most frequently deletions and duplications, have been known to be responsible for multiple congenital anomaly disorders. These rearrangements are implicated in syndromes that have some phenotypic resemblances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-015-0417-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546098PMC
August 2015
19 Reads
5 Citations
1.920 Impact Factor

Presentation of a Clitoral Mass in a Prepubescent Female: A Case Report and Discussion of the Evaluation.

Clin Med Insights Pediatr 2015 23;9:65-6. Epub 2015 Jun 23.

Division of Pediatric Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Clitoral masses are rare. We present a case report of a prepubescent female with a periclitoral mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S24535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479168PMC
June 2015
5 Reads

The effects of celecoxib or naproxen on blood pressure in pediatric patients with juvenile idiopathic arthritis.

Clin Med Insights Pediatr 2015 4;9:55-62. Epub 2015 May 4.

Connecticut Children's Medical Center, Hartford, CT, USA.

Background: Selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are indicated for the treatment of juvenile idiopathic arthritis (JIA). However, the effect of NSAIDs on blood pressure (BP) in children has not been rigorously examined.

Methods: In this randomized, double-blind, multicenter, active-controlled, 6-week trial, the safety and efficacy of celecoxib (50 mg twice daily [bid] or 100 mg bid) or naproxen (7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.s20720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425196PMC
May 2015
11 Reads

Mimics of duplication cysts: intraperitoneal nodules in a 14-year-old boy.

Clin Med Insights Pediatr 2015 8;9:49-53. Epub 2015 Apr 8.

Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.

Hemangiomas are the most common primary hepatic tumors, but there are few reports of their occurrence elsewhere in the abdomen. The concurrent existence of multiple fibrous nodules of the omentum, mesentery, and porta hepatis, along with a gastric hemangioma, in a child raises the question of syndromic association. Our search of the English literature revealed only rare mentions of hemangiomas involving the stomach and mesentery or omentum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S15683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395037PMC
April 2015
5 Reads

Normal Growth of Healthy Infants Born from HIV+ Mothers Fed a Reduced Protein Infant Formula Containing the Prebiotics Galacto-Oligosaccharides and Fructo-Oligosaccharides: A Randomized Controlled Trial.

Clin Med Insights Pediatr 2015 9;9:37-47. Epub 2015 Mar 9.

Nestlé Clinical Development Unit, Vevey, Switzerland.

Objective: The aim of the current study was to evaluate the safety of a new reduced protein (2.1 g/100 kcal) infant formula containing 4 g/L of 90% galacto-oligosaccharides (GOS) and 10% fructo-oligosaccharides (FOS).

Methods: Healthy term infants from Brazil were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S17841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357629PMC
October 2015
12 Reads

Intravenous lipids for preterm infants: a review.

Clin Med Insights Pediatr 2015 9;9:25-36. Epub 2015 Feb 9.

Pediatric Department, Royal Medical Services, Amman, Jordan.

Extremely low birth weight infants (ELBW) are born at a time when the fetus is undergoing rapid intrauterine brain and body growth. Continuation of this growth in the first several weeks postnatally during the time these infants are on ventilator support and receiving critical care is often a challenge. These infants are usually highly stressed and at risk for catabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S21161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325703PMC
February 2015
5 Reads

Cyclopia: a rare condition with unusual presentation - a case report.

Clin Med Insights Pediatr 2015 9;9:19-23. Epub 2015 Feb 9.

Paediatric Department, Royal Medical Services, Amman, Jordan.

Introduction: Cyclopia (alobar holoprosencephaly) (OMIM% 236100) is a rare and lethal complex human malformation, resulting from incomplete cleavage of prosencephalon into right and left hemispheres occurring between the 18th and the 28th day of gestation. Holoprosencephaly occurs in 1/16,000 live births, and 1/250 during embryogenesis. Approximately 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S21107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324465PMC
February 2015
5 Reads

Decreased plasma myeloperoxidase associated with probiotic therapy in autistic children.

Authors:
Anthony J Russo

Clin Med Insights Pediatr 2015 3;9:13-7. Epub 2015 Feb 3.

Hartwick College, Oneonta, NY, USA. ; Research Director, Health Research Institute and Pfeiffer Medical Center, Warrenville IL, USA.

Aim: To assess plasma myeloperoxidase (MPO) levels in autistic children and to test the hypothesis that there is an association between decreased MPO concentration and probiotic therapy.

Subjects And Methods: Plasma from 49 autistic children (39 males; mean age 11.4 years) (17 with diagnosed gastrointestinal (GI) disease - chronic diarrhea and/or constipation (10 of these GI patients were taking probiotics) and 26 receiving probiotic therapy) and 36 neurotypical controls (29 males; mean age 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S17901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319567PMC
February 2015
6 Reads

Hepatic dysfunction in asphyxiated neonates: prospective case-controlled study.

Clin Med Insights Pediatr 2015 12;9:1-6. Epub 2015 Jan 12.

ACPM Medical College, Dhule, Maharashtra, India.

Objective: This study was performed to determine the occurrence of hypoxic hepatitis in full-term neonates after perinatal asphyxia and to correlate between the rise in enzymes and severity of asphyxia with Apgar score and hypoxic ischemic encephalopathy (HIE) grading of the neonates.

Method And Material: This prospective case-controlled study was conducted in a tertiary-level hospital in India for a period of 12 months. The study group A comprised 70 newborns suffering from birth asphyxia, while 30 healthy neonates were included in group B (control). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S21426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294631PMC
February 2015
10 Reads
3 Citations

A case of hydrometrocolpos and polydactyly.

Clin Med Insights Pediatr 2015 14;9:7-11. Epub 2015 Jan 14.

Department of Obstetrics and Gynaecology, Fernandez Hospital, Hyderabad, India.

Neonatal hydrometrocolpos (HMC) is a rare Mullerian duct anomaly with an incidence of 0.006%. It occurs due to blockage of the vagina with accumulation of mucus secretions proximal to the obstacle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S20787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295912PMC
January 2015
5 Reads

Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas: a randomized controlled multicenter non-inferiority trial in healthy term infants.

Clin Med Insights Pediatr 2014 3;8:51-60. Epub 2014 Nov 3.

Nestlé Clinical Development Unit, Nestec Ltd, Vevey, Switzerland.

Objective: This multicenter non-inferiority study evaluated the safety of infant formulas enriched with bovine milk fat globule membrane (MFGM) fractions.

Methods: Healthy, full-term infants (n = 119) age ≤14 days were randomized to standard infant formula (control), standard formula enriched with a lipid-rich MFGM fraction (MFGM-L), or standard formula enriched with a protein-rich MFGM fraction (MFGM-P). Primary outcome was mean weight gain per day from enrollment to age 4 months (non-inferiority margin: -3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S16962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219856PMC
December 2014
15 Reads

Distal Deletion of Chromosome 11q Encompassing Jacobsen Syndrome without Platelet Abnormality.

Clin Med Insights Pediatr 2014 17;8:45-9. Epub 2014 Sep 17.

Foundation for Research in Genetics and Endocrinology's Institute of Human Genetics, FRIGE House, Ahmedabad, India.

Terminal 11q deletion, known as Jacobsen syndrome (JBS), is a rare genetic disorder associated with numerous dysmorphic features. We studied two cases with multiple congenital anomalies that were cytogenetically detected with deletions on 11q encompassing JBS region: 46,XX,der(11) del(11)(q24). Array comparative genomic hybridization (aCGH) analysis confirmed partial deletion of 11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S18121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179602PMC
October 2014
16 Reads

Factors associated with delayed cancer diagnosis in egyptian children.

Clin Med Insights Pediatr 2014 4;8:39-44. Epub 2014 Sep 4.

Clinical Research Specialist, Children's Cancer Hospital, Egypt.

Background: Despite tremendous importance of early cancer diagnosis in children, few studies on this topic have been conducted in Egypt. Early stage diagnosis can have a positive effect on prognoses and the quality of life of children with cancer. We investigated delays in the diagnosis of childhood cancers in Egypt and determined the factors associated with these delays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S16413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159362PMC
September 2014
6 Reads

Clinical options for the treatment of urinary tract infections in children.

Clin Med Insights Pediatr 2014 24;8:31-7. Epub 2014 Aug 24.

Goldthorpe Medical Centre, Barnsley, UK.

Urinary Tract Infections (UTI) are a common cause of childhood febrile illness with 7% of girls and 2% of boys having a symptomatic culture positive UTI by the age of six years. Although there are conflicting views on the long term sequelae of UTI, as well as the place of prophylaxis, the universal aims of treatment of childhood UTI remain those of symptom alleviation, prevention of systemic infection and short and longer term complications. There is good evidence of historical and emerging resistance patterns, therefore rationalisation of prescription patterns by knowledge of sensitivities coupled with re-examination of empirical antibiotic choices is clearly important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CMPed.S8100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149380PMC
September 2014
4 Reads