45 results match your criteria Clinical Medicine Insights: Pathology [Journal]

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A Colonic Perineurioma.

Clin Med Insights Pathol 2018 6;11:1179555718815918. Epub 2018 Dec 6.

Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.

Perineurioma is a mesenchymal neoplasm best known in soft-tissue pathology. A colonic perineurioma is a relatively recently described entity and sometimes encountered in specimens from the large intestine, especially distal colon. Without its recognition, a perineurioma can be misdiagnosed as other more common gastrointestinal spindle cell neoplasms. Read More

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http://dx.doi.org/10.1177/1179555718815918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295680PMC
December 2018
5 Reads

Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features.

Clin Med Insights Pathol 2018 4;11:1179555718809071. Epub 2018 Nov 4.

Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX, USA.

Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. Unfortunately, IT methotrexate can cause several neurologic complications, including transverse myelopathy; ie, the development of isolated spinal cord dysfunction over hours or days following the IT infusion of methotrexate, but in the absence of a compressive lesion. Read More

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http://dx.doi.org/10.1177/1179555718809071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236481PMC
November 2018
15 Reads

Autopsy Patients With Obesity or Metabolic Syndrome as Basic Cause of Death: Are There Pathological Differences Between These Groups?

Clin Med Insights Pathol 2018 30;11:1179555718791575. Epub 2018 Jul 30.

Department of Pathology, School of Medicine of Botucatu, São Paulo State University, FMB-UNESP, Botucatu, Brazil.

Background: The objectives of this study were the evaluation of pathological characteristics of patients with obesity or metabolic syndrome (MS) as basic cause of death, associating the autopsy findings with some clinical aspects and the abdominal adipose panicle thickness.

Methods: A total of 88 autopsy cases were studied, divided into 2 groups based on the main cause of death: group 1 (n = 15) obesity and group 2 (n = 73) MS. Clinical summaries of autopsy requests, macroscopic findings, and histologic sections were reviewed. Read More

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http://journals.sagepub.com/doi/10.1177/1179555718791575
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http://dx.doi.org/10.1177/1179555718791575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066805PMC
July 2018
13 Reads

Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases.

Clin Med Insights Pathol 2018 5;11:1179555718757499. Epub 2018 Feb 5.

Department of Pathology, Hassan II University Hospital, Fès, Morocco.

Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors. Read More

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http://dx.doi.org/10.1177/1179555718757499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808954PMC
February 2018
12 Reads

Effects of Prolonged Treatment With Co-trimoxazole on the Thyroid Gland, Liver, and Epididymal Sperm Reserve in Dogs.

Clin Med Insights Pathol 2017 7;10:1179555717742881. Epub 2017 Dec 7.

Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria.

Co-trimoxazole is an antimicrobial drug gotten from potentiation of sulfamethoxazole with trimethoprim. It is widely used for the treatment of bacterial and protozoan infections in humans. It is also used in veterinary clinics against susceptible microorganisms, but thyroid dysfunction has raised concern especially in dogs. Read More

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http://dx.doi.org/10.1177/1179555717742881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724629PMC
December 2017
11 Reads

Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site.

Clin Med Insights Pathol 2017 15;10:1179555717694556. Epub 2017 Nov 15.

Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.

Previous studies have identified a CCAAT/enhancer binding protein (C/EBP) site located downstream of the transcriptional start site (DS3). The role of the DS3 element with respect to HIV-1 transactivation by Tat and viral replication has not been characterized. We have demonstrated that DS3 was a functional C/EBPβ binding site and mutation of this site to the C/EBP knockout DS3-9C variant showed lower HIV-1 long terminal repeat (LTR) transactivation by C/EBPβ. Read More

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http://dx.doi.org/10.1177/1179555717694556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692137PMC
November 2017
12 Reads

Impact of Pathology Review for Decision Therapy in Localized Prostate Cancer.

Clin Med Insights Pathol 2017 2;10:1179555717740130. Epub 2017 Nov 2.

Oncology Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: The Gleason score is an essential tool in the decision to treat localized prostate cancer. However, experienced pathologists can classify Gleason score differently than do low-volume pathologists, and this may affect the treatment decision. This study sought to assess the impact of pathology review of external biopsy specimens from 23 men with a recent diagnosis of localized prostate cancer. Read More

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http://dx.doi.org/10.1177/1179555717740130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672998PMC
November 2017
12 Reads

Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer.

Clin Med Insights Pathol 2017 6;10:1179555717729652. Epub 2017 Sep 6.

Department of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.

Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Read More

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http://dx.doi.org/10.1177/1179555717729652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590696PMC
September 2017
7 Reads

Pulmonary Cryptococcosis Presenting With Lung Mass: Report of 7 Cases and Review of Literature.

Clin Med Insights Pathol 2017 4;10:1179555717722962. Epub 2017 Aug 4.

Division of Infectious Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Pulmonary cryptococcosis is commonly found in immunocompromised patients. This microorganism rarely infects immunocompetent individuals, and when it does, it causes mild symptoms. The radiological findings of this disease may involve an intrapulmonary mass that mimics lung tumor. Read More

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http://dx.doi.org/10.1177/1179555717722962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546643PMC
August 2017
6 Reads

Is Tolerance Broken in Autoimmunity?

Clin Med Insights Pathol 2017 16;10:1179555717712716. Epub 2017 May 16.

Editor in Chief, Clinical Medicine Insights: Pathology; Sathya Krishna Genomics LLC, Winston-Salem, NC, USA.

Autoimmune diseases are classified into about 80 different types based on their specificity related to system, organ and/or tissue. About 5% of the western population is affected by this anomaly, but its worldwide incidence is unknown. Autoimmune diseases are heterogeneous in nature and clinical manifestations range from benign disorders to life-threatening conditions. Read More

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http://dx.doi.org/10.1177/1179555717712716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439997PMC
May 2017
13 Reads

A Little Help From the Follicles: Understanding the Germinal Center Response to Human Immunodeficiency Virus 1 Infection and Prophylactic Vaccines.

Clin Med Insights Pathol 2017 30;10:1179555717695548. Epub 2017 Mar 30.

Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, PA, USA.

Human immunodeficiency virus 1 (HIV-1) is the causative agent of AIDS. There are currently more than 35 million people living with HIV infection worldwide, and more than 2 million new infections occur each year. The global pandemic caused by HIV-1 is the subject of numerous research projects, with the development of a prophylactic vaccine and a therapeutic cure being the ultimate goals. Read More

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http://dx.doi.org/10.1177/1179555717695548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398647PMC
March 2017
7 Reads

cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells.

Clin Med Insights Pathol 2017 10;10:1179555717694535. Epub 2017 Mar 10.

Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.

CD34 hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we have explored the impact of forskolin on cell surface expression of CXCR4 in a cell line model (TF-1). The elevation of intracellular cyclic adenosine monophosphate (cAMP) by forskolin through adenylyl cyclase (AC) resulted in transcriptional upregulation of CXCR4 with a concomitant increase in replication of the CXCR4-utilizing HIV-1 strain IIIB. Read More

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http://dx.doi.org/10.1177/1179555717694535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398651PMC
March 2017
14 Reads

Hanging Fatalities in Central Bangkok, Thailand: A 13-Year Retrospective Study.

Clin Med Insights Pathol 2017 23;10:1179555717692545. Epub 2017 Feb 23.

Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Hanging is violent asphyxial death. The objective of this study is to assess the data of hanging cases. A descriptive-retrospective study was conducted. Read More

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http://dx.doi.org/10.1177/1179555717692545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398332PMC
February 2017
6 Reads

Primary Melanotic Paraganglioma of Thyroid Gland: Report of a Rare Case With Clinicopathologic and Immunohistochemical Analysis and a Literature Review.

Clin Med Insights Pathol 2017 22;10:1179555716684670. Epub 2017 Feb 22.

Department of Imageology, Binzhou Medical University Hospital, Binzhou, China.

Background: Pigmented paraganglioma is a special type of paraganglioma, and it is rare in the thyroid.

Case Presentation: We report a case of a 41-year-old woman who had complained of a mass in the thyroid gland. Histology revealed tumor cells arranged in a nest-like or organoid pattern, separated by delicate fibrovascular septa. Read More

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http://dx.doi.org/10.1177/1179555716684670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398289PMC
February 2017
18 Reads

Sudden Cardiac Death of a Body Packer Due to Cocaine Cardiotoxicity.

Clin Med Insights Pathol 2016 24;9:33-35. Epub 2016 Nov 24.

Department of Forensic Medicine AIIMS BHOPAL, India.

This article presents a case of sudden cardiac death due to the effects of cocaine concealed in the body of a male drug smuggler in his 40s, a so-called body packer. A total of 57 body packets filled with cocaine powder were discovered in his body cavities. The detailed autopsy examination, including histopathology and toxicology findings, is discussed with the aim of describing the mechanism of cocaine intoxication in the body packer and an analysis of cocaine-induced cardiotoxicity and sudden death. Read More

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http://journals.sagepub.com/doi/10.4137/CPath.S41070
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http://dx.doi.org/10.4137/CPath.S41070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123768PMC
November 2016
7 Reads

IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity.

Clin Med Insights Pathol 2016 21;9(Suppl 1):21-28. Epub 2016 Nov 21.

Lankenau Institute for Medical Research, Wynnewood, PA, USA.

Indoleamine 2,3-dioxygenase 2 (IDO2), a homolog of the better-studied tryptophan-catabolizing enzyme IDO1, is an immunomodulatory molecule with potential effects on various diseases including cancer and autoimmunity. Here, we review what is known about the direct connections between IDO2 and immune function, particularly in relationship to autoimmune inflammatory disorders such as rheumatoid arthritis and lupus. Accumulating evidence indicates that IDO2 acts as a pro-inflammatory mediator of autoimmunity, with a functional phenotype distinct from IDO1. Read More

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http://dx.doi.org/10.4137/CPath.S39930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119657PMC
November 2016
7 Reads

Interferon Gamma: Influence on Neural Stem Cell Function in Neurodegenerative and Neuroinflammatory Disease.

Clin Med Insights Pathol 2016 13;9(Suppl 1):9-19. Epub 2016 Oct 13.

Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA.

Interferon-gamma (IFNγ), a pleiotropic cytokine, is expressed in diverse neurodegenerative and neuroinflammatory conditions. Its protective mechanisms are well documented during viral infections in the brain, where IFNγ mediates non-cytolytic viral control in infected neurons. However, IFNγ also plays both protective and pathological roles in other central nervous system (CNS) diseases. Read More

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http://dx.doi.org/10.4137/CPath.S40497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065109PMC
October 2016
27 Reads

Cytopathological Diagnosis of an Unusual Cause of Malignant Hydrocele.

Clin Med Insights Pathol 2016 4;9:29-31. Epub 2016 Oct 4.

Clinical Haematology and BMT unit, Department of Internal Medicine, PGIMER Chandigarh, Chandigarh, India.

Testicular involvement in a case of acute lymphoblastic leukemia (ALL) is well reported, but occurrence of "isolated" malignant hydrocele is extremely uncommon. We herein report a case of a 22-year-old man who presented to our hematology clinic with fever and easy fatiguability of 2 weeks' duration. Examination revealed pallor, cervical lymphadenopathy, and bilateral scrotal swellings. Read More

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http://dx.doi.org/10.4137/CPath.S40517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053201PMC
October 2016
24 Reads

Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells.

Clin Med Insights Pathol 2016 14;9(Suppl 1):1-8. Epub 2016 Sep 14.

Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA.

Exosome-mediated signaling is important in mediating the inflammatory response. To exert their biological or pathophysiological functions in the recipient cells, exosomes deliver a diverse array of biomacromolecules including long and short coding and non-coding RNAs, proteins, and lipids. Exosomes secreted by antigen-presenting cells can confer therapeutic benefits by attenuating or stimulating the immune response. Read More

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http://dx.doi.org/10.4137/CPath.S39925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024790PMC
September 2016
7 Reads

Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study.

Clin Med Insights Pathol 2016 7;9:19-28. Epub 2016 Sep 7.

Department of Pathology, Oslo University Hospital, Oslo, Norway.

Data are limited on oncogene mutation frequencies in polyps from principally asymptomatic participants of population-based colorectal cancer screening studies. In this study, DNA from 204 polyps, 5 mm or larger, were collected from 176 participants of the NORCCAP screening study and analyzed for mutations in KRAS, BRAF, and PIK3CA including the rarely studied KRAS exons 3 and 4 mutations. KRAS mutations were identified in 23. Read More

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http://dx.doi.org/10.4137/CPath.s40143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015815PMC
September 2016
12 Reads

Phyllodes Tumor in a Lactating Breast.

Clin Med Insights Pathol 2016 6;9:13-7. Epub 2016 Apr 6.

Registrar, Department of Pathology Laboratory Medicine, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Phyllodes tumor is attributed to a small fraction of primary tumors of the breast. Such tumors occur rarely in pregnancy and lactation. We report a case of a 25-year-old lactating mother presenting with a lump in the left breast. Read More

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http://dx.doi.org/10.4137/CPath.S38476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824323PMC
April 2016
8 Reads
1 Citation

Diagnostic Implication and Clinical Relevance of Ancillary Techniques in Clinical Pathology Practice.

Authors:
Jaafar S Makki

Clin Med Insights Pathol 2016 23;9:5-11. Epub 2016 Mar 23.

Senior Pathologist, Pathology Department, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

Hematoxylin-eosin-stained slide preparation is one of the most durable techniques in medicine history, which has remained unchanged since implemented. It allows an accurate microscopic diagnosis of the vast majority of tissue samples. In many circumstances, this technique cannot answer all the questions posed at the initial diagnostic level. Read More

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http://dx.doi.org/10.4137/CPath.S32784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807883PMC
April 2016
71 Reads

Targeted therapies and immune checkpoint inhibitors in the treatment of metastatic melanoma patients: a guide and update for pathologists.

Pathology 2016 Feb 20;48(2):194-202. Epub 2016 Jan 20.

Melanoma Institute Australia, North Sydney, Australia; The University of Sydney, Sydney, Australia; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. Electronic address:

The previously dismal prospects for patients with advanced stage metastatic melanoma have greatly improved in recent years. Enhanced understanding of both the pathogenesis of melanoma and its molecular drivers, as well as the importance and regulation of anti-tumour immune responses, have provided new therapeutic opportunities for melanoma patients. There are two major distinct categories of systemic treatments with activity for patients with metastatic melanoma: (1) targeted therapies, which act to inhibit the oncogenes that drive the aberrant growth and dissemination of the tumour; and (2) immune checkpoint inhibitor therapies, which act to enhance anti-tumour immune responses by blocking negative regulators of immunity. Read More

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http://dx.doi.org/10.1016/j.pathol.2015.12.010DOI Listing
February 2016
21 Reads

A Case Report: A Third/Fourth Branchial Pouch Anomaly Presented by Solid Thyroid and Lateral Cervical Neck Masses.

Clin Med Insights Pathol 2016 18;9:1-3. Epub 2016 Jan 18.

Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Branchial pouch-derived anomalies may arise from remnants of the first, second, or third/fourth branchial arches. Branchial pouch-related structures are found within the thyroid gland in the form of solid cell rests, epithelial lined cyst with or without an associated lymphoid component, thymic and/or parathyroid tissue, and less commonly in the form of heterotopic cartilage. We present a rare case of left solid thyroid swelling nearby two cervical nodules in a seven-year-old female with a clinical diagnosis suggestive of malignant thyroid tumor with metastasis to the cervical lymph nodes. Read More

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http://dx.doi.org/10.4137/CPath.S31734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718085PMC
January 2016
11 Reads

Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance.

Authors:
Jaafar Makki

Clin Med Insights Pathol 2015 21;8:23-31. Epub 2015 Dec 21.

Senior Pathologist, Pathology Department, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia.

Mammary carcinoma is the most common malignant tumor in women, and it is the leading cause of mortality, with an incidence of >1,000,000 cases occurring worldwide annually. It is one of the most common human neoplasms, accounting for approximately one-quarter of all cancers in females worldwide and 27% of cancers in developed countries with a Western lifestyle. They exhibit a wide scope of morphological features, different immunohistochemical profiles, and unique histopathological subtypes that have specific clinical course and outcome. Read More

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http://dx.doi.org/10.4137/CPath.S31563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689326PMC
January 2016
24 Reads
95 Citations

Comparison of the blood and lymphatic microvessel density of pleomorphic adenoma and Basal cell adenoma.

Clin Med Insights Pathol 2015 19;8:17-21. Epub 2015 Apr 19.

Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.

Background: Pleomorphic adenoma (PA) is the most common tumor of the salivary gland, while basal cell adenoma (BCA) is an uncommon neoplasm. Blood and lymphatic vessels are crucial for tumor metabolism. The aim of this study was to compare the blood and lymphatic vascular density and vascular and endothelial growth factor (VEGF) expression in PA and BCA tumors. Read More

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http://dx.doi.org/10.4137/CPath.S23035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405080PMC
May 2015
9 Reads

Expression distribution of cancer stem cells, epithelial to mesenchymal transition, and telomerase activity in breast cancer and their association with clinicopathologic characteristics.

Clin Med Insights Pathol 2015 7;8:1-16. Epub 2015 Jan 7.

Biotechnology Research Institute Universiti Malaysia Sabah, Sabah, Malaysia.

A total of 167 surgically resected primary invasive breast carcinomas and 63 metastatic lymph node lesions were analyzed for immunohistochemical (IHC) localization of the CD44(+)CD24(-low) breast cancer stem cell (CSC) markers, epithelial to mesenchymal transition (EMT) markers, and telomerase activity by double-staining IHC technique, in formalin-fixed, paraffin-embedded tissue, the results were validated by double-staining immunofluorescent and flow cytometry techniques. The results showed that CSCs with CD44(+)CD24(-low) phenotype were significantly increased in node-positive tumors, high-grade tumors, and ductal carcinoma in situ (DCIS). There was a high incidence of telomerase expression in metastatic lymph node lesion. Read More

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http://dx.doi.org/10.4137/CPath.S19615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287054PMC
January 2015
13 Reads

Chronic Lymphocytic Leukemia with t(14;18)(q32;q21) As a Sole Cytogenetic Abnormality.

Clin Med Insights Pathol 2014 23;7:21-7. Epub 2014 Sep 23.

Department of Adult Clinical Hematology and Stem cell Therapy, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with neoplasms of a follicular center cell origin. However, t(14;18) has also been reported in rare cases of CLL. Read More

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http://dx.doi.org/10.4137/CPath.S17818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179603PMC
October 2014
10 Reads

Thoracic epidural teratoma: case report and review of the literature.

Clin Med Insights Pathol 2014 9;7:15-20. Epub 2014 Jun 9.

Department of Neurosurgery, Yale-New Haven Medical Center, New Haven, CT, USA.

Purpose: Spinal teratomas comprise a rare subset of spinal cord tumors, and here, we describe an even rarer childhood thoracic extradural-intracanalicular teratoma. The clinical presentation, management, and pathophysiology of these tumors are reviewed to promote recognition and guide treatment of these lesions.

Methods: We report the case of a 21-month-old boy who presented with marked spasticity, as well as failure to ambulate and meet motor milestones. Read More

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http://dx.doi.org/10.4137/CPath.S14723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055415PMC
June 2014
6 Reads

Reappraisal of the etiology of extracorpuscular non-autoimmune acquired hemolytic anemia in 2657 hospitalized patients with non-neoplastic disease.

Clin Med Insights Pathol 2014 15;7:11-4. Epub 2014 Apr 15.

Institute of Environmental Health, China Medical University College of Public Health, Taichung, Taiwan.

Introduction: Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real-world etiology or mechanisms of the non-hereditary non-AIHA from a nationwide population-based administrative claim database in Taiwan. Read More

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http://dx.doi.org/10.4137/CPath.S14875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999811PMC
May 2014
16 Reads

Molecular insights into systemic lupus erythematosus pathogenesis.

Clin Med Insights Pathol 2014 20;7:7-9. Epub 2014 Mar 20.

Editor in Chief, Clinical Medicine Insights: Pathology, Formerly with Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.4137/CPath.S14814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964202PMC
March 2014
7 Reads

Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center.

Clin Med Insights Pathol 2014 16;7:1-5. Epub 2014 Jan 16.

Teerthanker Mahaveer Medical College and Research Center, Moradabad, Uttar Pradesh, India.

Introduction: Hashimoto's thyroiditis is the most common form of acquired hypothyroidism. Fine needle aspiration cytology is one important tool in diagnosing Hashimoto's thyroditis, along with clinical, biochemical, immunological and ultrasonographical modalities. The present study examines cytological aspects of Hashimoto's thyroiditis along with their correlation with clinical, biochemical and immunological findings, whenever available. Read More

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http://dx.doi.org/10.4137/CPath.S13580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921154PMC
February 2014
7 Reads
4 Citations

Benign pairs: a significant entity in aspiration cytology smears from breast lesions.

Clin Med Insights Pathol 2013 28;6:13-6. Epub 2013 Nov 28.

Teerthanker Mahaveer Medical College and Research Centre, Moradabad, India. ; Department of Pathology, Sarojini Naidu Medical College, Agra, India.

Introduction: Fine needle aspiration cytology (FNAC) is a reliable diagnostic tool used to diagnose breast lesions preoperatively. However, FNAC is also associated with diagnostic pitfalls. Further studies are needed to improve its diagnostic efficacy. Read More

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http://dx.doi.org/10.4137/CPath.S13273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855199PMC
December 2013
9 Reads

Pathology of gastrointestinal stromal tumors.

Clin Med Insights Pathol 2012 17;5:23-33. Epub 2012 Jul 17.

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neither KIT nor PDGFRA mutations may have germline mutations in SDH, suggesting a potential role of SDH in the pathogenesis. Read More

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http://dx.doi.org/10.4137/CPath.S9689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408870PMC
August 2012
7 Reads

Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples.

Clin Med Insights Pathol 2012 15;5:15-22. Epub 2012 May 15.

AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK.

Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging. This study assessed the identification of KRAS mutations in circulating free DNA (cfDNA) using a commercially available KRAS polymerase chain reaction (PCR) kit. Matched plasma, serum and tumor samples were available from 71 patients with mCRC who had received prior therapy but whose disease progressed following therapy. Read More

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http://dx.doi.org/10.4137/CPath.S8798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362326PMC
August 2012
10 Reads

Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology.

Clin Med Insights Pathol 2012 29;5:11-4. Epub 2012 Mar 29.

Fatih Sultan Mehmet Training and Research Hospital, Department of General Surgery, Istanbul, Turkey.

Corticosteroids are used in the treatment of many rheumatological diseases including temporal arteritis. The gastrointestinal perforation during corticosteroid treatment is a serious complication. Colon perforation after steroid use was first reported by Beck et al in 1950. Read More

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http://dx.doi.org/10.4137/CPath.S7924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320117PMC
August 2012
13 Reads

Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy.

Clin Med Insights Pathol 2012 26;5:7-10. Epub 2012 Feb 26.

Fellow in the Department of Hematology and Oncology, Staten Island University Hospital.

Kikuchi's disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Read More

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http://dx.doi.org/10.4137/CPath.S8685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296495PMC
August 2012
14 Reads

Clinical features and differential diagnoses in laryngeal mucoepidermoid carcinoma.

Clin Med Insights Pathol 2012 6;5:1-6. Epub 2011 Dec 6.

Department of Oral and Maxillofacial Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. However, it is a rare entity in larynx. Laryngeal cases are frequently misdiagnosed with other malignancies and they are under-reported. Read More

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http://dx.doi.org/10.4137/CPath.S8435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256999PMC
August 2012
6 Reads

Different clinical presentation of appendicolithiasis. The report of three cases and review of the literature.

Clin Med Insights Pathol 2011 Mar 30;4:1-4. Epub 2011 Mar 30.

Fatih Sultan Mehmet Training and Research Hospital, Department of General Surgery, Istanbul, Turkey.

An appendicolith is composed of firm feces and some mineral deposits. After increased use of abdominal computed tomography, appendicoliths are more frequently detected. Most of the patients with appendicolith are asymptomatic. Read More

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http://dx.doi.org/10.4137/CPath.S6757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072212PMC
March 2011
8 Reads
3 Citations

Congenital amegakaryocytic thrombocytopenia: a brief review of the literature.

Clin Med Insights Pathol 2010 Jun 4;3:25-30. Epub 2010 Jun 4.

Division of Hematology, Department of Pathology. King Khalid University Hospital. King Saud University Riyadh, Kingdom of Saudi Arabia.

Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited autosomal recessive disorder that presents with thrombocytopenia and absence of megakaryocytes. It presents with bleeding recognized on day 1 of life or at least within the first month. The cause for this disorder appears to be a mutation in the gene for the thrombopoeitin (TPO) receptor, c-Mpl, despite high levels of serum TPO. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999995PMC
June 2010
9 Reads

Cardiovascular disease and its association with histological changes of the left stellate ganglion.

Clin Med Insights Pathol 2010 Jun 1;3:19-24. Epub 2010 Jun 1.

Academic Medicine Fellow, Department of Pathology, New York College of Osteopathic Medicine, Old Westbury, NY.

Mounting evidence has demonstrated that the autonomic system plays a role in the morbidity and mortality of certain cardiovascular disease states. Ventricular arrhythmias have been associated with the level of sympathetic activation. We attempted to determine if the presence of fibrosis, a marker for previous ischemic events, correlates with an increase in the number of left stellate ganglion nerve cell bodies which is indicative of hypersympathetic stimulation to the myocardial tissue. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999999PMC
June 2010
6 Reads

Pneumococcal Induced T-activation with Resultant Thrombotic Microangiopathy.

Clin Med Insights Pathol 2010 May 19;3:13-7. Epub 2010 May 19.

Texas Tech University Health Sciences Center School of Medicine, Department of Pathology, Lubbock, TX, USA.

Thrombotic microangiopathies are disorders resulting from platelet thromboses forming in the microvasculature with resultant schistocyte forms. Hemolytic uremic syndrome (HUS) is a microangiopathic hemolytic anemia often complicated by acute renal failure in children. HUS is typically caused by bacterial infection, most commonly enterohemorrhagic Escherichia coli. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999997PMC
May 2010
16 Reads

Intussusception Caused by Yersinia enterocolitica Enterocolitis in a Patient with Sickle Cell Anemia.

Clin Med Insights Pathol 2010 May 13;3:7-11. Epub 2010 May 13.

Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India 607402.

Yersinia enterocolitica intussusception is rarely encountered in patients without an underlying susceptibility and is most frequently reported in iron-overloaded patients. This is thought to be related to the unusual use of iron by this microorganism. We present a case of a 5-year old child with intussusception of the terminal ileum caused by Y. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999996PMC
May 2010
5 Reads

Bilateral Basal cell adenocarcinoma of the parotid gland: in a recipient of kidney transplant.

Clin Med Insights Pathol 2010 Feb 18;3:1-5. Epub 2010 Feb 18.

Department of Otolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, and Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland.

We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy. BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991. Over 90% of BcACs are detected in the parotid gland. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999998PMC
February 2010
8 Reads
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