85 results match your criteria Clinical Medicine Insights: Gastroenterology [Journal]


Genetics of Familial and Sporadic Pancreatic Cancer.

Gastroenterology 2019 Jan 17. Epub 2019 Jan 17.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

In the previous decade, comprehensive genomic analyses have yielded important insights about the genetic alterations that underlie pancreatic tumorigenesis. Whole exome and whole genome sequencing of pancreatic ductal adenocarcinomas have confirmed the critical driver genes altered in the majority of pancreatic cancers, as well as identifying numerous less frequently altered driver genes and has delineated cancer subgroups with unique biological and clinical features. It is now appreciated that pancreatic susceptibility gene alterations are often identified in patients with pancreatic cancer without family histories suggestive of a familial cancer syndrome, prompting recent efforts to expand gene testing to all patients with pancreatic cancer. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.039DOI Listing
January 2019
1 Read

Biodegradable Stents in Resistant Peptic Oesophageal Stricture: Is It the Right Way to Go?

Clin Med Insights Gastroenterol 2018 20;11:1179552218819492. Epub 2018 Dec 20.

Department of Digestive Diseases, Warrington Hospital, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, UK.

Peptic oesophageal stricture can be considered as the end result of prolonged gastro-oesophageal reflux. The 'gold standard' treatment for peptic stricture is endoscopic dilatation with balloon or bougie. It is predicted that up to 40% of patients remain symptomatic with dysphagia due to refractory (resistant to treatment) or recurrent strictures, needing frequent interventions at short intervals. Read More

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http://journals.sagepub.com/doi/10.1177/1179552218819492
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http://dx.doi.org/10.1177/1179552218819492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309028PMC
December 2018
5 Reads

Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?

Clin Med Insights Gastroenterol 2018 4;11:1179552218817321. Epub 2018 Dec 4.

Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Technion Faculty of Medicine, Hadera, Israel.

Background: Melanosis coli, a brown discoloration of colonic mucosa, is considered as a benign condition mainly observed in patients under chronic anthranoid laxatives. Recent data link this condition with an increased adenoma detection rate. Moreover, its tumorigenic potential and possible association with the development of colorectal cancer remains uncertain. Read More

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http://dx.doi.org/10.1177/1179552218817321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299301PMC
December 2018
10 Reads

Understanding Therapeutic Concepts in Crohn's Disease.

Authors:
Gilles Rg Monif

Clin Med Insights Gastroenterol 2018 3;11:1179552218815169. Epub 2018 Dec 3.

Infectious Diseases Inc., Bellevue, NE, USA.

For more than a decade, the therapeutic focus for Crohn's disease has remained fixed at temporary arrestment of symptomology. The Centers for Disease Control and Prevention (CDC) lists Crohn's disease as a disease entity without current cure. Biologics in combination with antibiotics can frequently achieve remissions. Read More

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http://dx.doi.org/10.1177/1179552218815169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287291PMC
December 2018
9 Reads

The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial.

Clin Med Insights Gastroenterol 2018 26;11:1179552218811834. Epub 2018 Nov 26.

Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Brazil.

Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. Read More

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http://dx.doi.org/10.1177/1179552218811834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256309PMC
November 2018
2 Reads

Impact of Video Aid on Quality of Bowel Preparation Among Patients Undergoing Outpatient Screening Colonoscopy.

Clin Med Insights Gastroenterol 2018 8;11:1179552218803304. Epub 2018 Oct 8.

Division of Gastroenterology and Nutrition, Department of Digestive Diseases and Transplantation, Einstein Medical Center Philadelphia, Philadelphia, PA, USA.

Aim: To investigate the effect of video aid on quality of bowel preparation.

Study: A retrospective study was done on patients undergoing outpatient screening colonoscopy. All subjects received educational video prior to colonoscopy in addition to the standard counseling. Read More

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http://dx.doi.org/10.1177/1179552218803304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176536PMC
October 2018
1 Read

Genetic Factors That Affect Spontaneous Clearance of Hepatitis C or B Virus, Response to Treatment, and Disease Progression.

Gastroenterology 2019 01 1;156(2):400-417. Epub 2018 Oct 1.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Unit, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections can lead to cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Over the past decade, studies of individuals infected with these viruses have established genetic associations with the probability of developing a chronic infection, risk of disease progression, and likelihood of treatment response. We review genetic and genomic methods that have been used to study risk of HBV and HCV infection and patient outcomes. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.09.052DOI Listing
January 2019
3 Reads

Insights From Antiviral Therapy Into Immune Responses to Hepatitis B and C Virus Infection.

Gastroenterology 2019 01 26;156(2):369-383. Epub 2018 Sep 26.

Klinik für Innere Medizin II, University Hospital Freiburg, Faculty of Medicine, Freiburg, Germany.

There are 257 million persons worldwide with chronic hepatitis B virus (HBV) infection, a leading causes of liver cancer. Almost all adults with acute HBV infection have a rapid immune response to the virus, resulting in life-long immunity, but there is no cure for individuals with chronic HBV infection, which they acquire during early life. The mechanisms that drive the progression of HBV through distinct clinical phases to end-stage liver disease are poorly understood. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.08.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340757PMC
January 2019
6 Reads

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass.

Clin Med Insights Gastroenterol 2018 24;11:1179552218801603. Epub 2018 Sep 24.

Department of Gastroenterology, Sinai Hospital, Baltimore, MD, USA.

Extramedullary plasmacytomas (EMP) are a subcategory of plasma cell neoplasm that involves organs outside the bone marrow. Involvement of the pancreas is relatively rare, reported in only 2.3% of autopsies. Read More

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http://dx.doi.org/10.1177/1179552218801603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153524PMC
September 2018
7 Reads

Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index.

Clin Med Insights Gastroenterol 2018 30;11:1179552218791173. Epub 2018 Jul 30.

Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.

We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn's disease (CD) activity index (CDAI) in patients with CD.

Methods: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity.

Results: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). Read More

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http://dx.doi.org/10.1177/1179552218791173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066806PMC
July 2018
2 Reads

Esophageal Adenocarcinoma: Opportunities for Targeted Prevention in Ohio.

Clin Med Insights Gastroenterol 2018 30;11:1179552218791170. Epub 2018 Jul 30.

Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

Objective: The incidence of esophageal adenocarcinoma, one of the most lethal gastroenterological diseases, has been increasing since the 1960s. Prevention of esophageal adenocarcinoma is important because no early detection screening programs have been shown to reduce mortality. Obesity, gastroesophageal reflux disease, and tobacco smoking are risk factors for esophageal adenocarcinoma. Read More

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http://dx.doi.org/10.1177/1179552218791170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066804PMC
July 2018
16 Reads

Gastroduodenal Tuberculosis: A Case Series and Review of Literature.

Clin Med Insights Gastroenterol 2018 30;11:1179552218790566. Epub 2018 Jul 30.

Department of Gastroenterology, Topiwala National Medical College & B.Y.L Nair Charitable Hospital, Mumbai, India.

Gastroduodenal tuberculosis is infrequently seen in day-to-day clinical practice with few cases reported in the literature. It is usually associated with features of gastric outlet obstruction. This is a case series of 4 patients with 2 of them having associated lower gastrointestinal involvement. Read More

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http://dx.doi.org/10.1177/1179552218790566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066802PMC
July 2018
22 Reads

A Case of Acute Severe Hepatotoxicity and Mild Constriction of Common Bile Duct Associated With Ingestion of Green Tea Extract: A Clinical Challenge.

Clin Med Insights Gastroenterol 2018 5;11:1179552218779970. Epub 2018 Jun 5.

LifeBridge health Department of Gastroenterology, Sinai Hospital, Baltimore, MD, USA.

Consumption of herbal and dietary supplements (HDS) has increased worldwide as potential treatment for weight reduction and metabolic enhancement. However, it has been reported that HDS can cause liver injury which accounts for 20% of hepatotoxicity in the United States. Prevention of HDS induced liver injury remains a challenge due to difficulties in identifying the hepatotoxins in these preparations and lack of federal regulations for dietary supplements. Read More

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http://dx.doi.org/10.1177/1179552218779970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058416PMC
June 2018
3 Reads

An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease.

Clin Med Insights Gastroenterol 2018 10;11:1179552218787502. Epub 2018 Jul 10.

Office of Professional Affairs, Department of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX, USA.

Background: Nonalcoholic fatty liver disease (NAFLD) is a common complication in patients with metabolic syndrome. The role of statin therapy specifically for the treatment of NAFLD remains unknown. The aim of this review is to discuss outcomes of recent articles analyzing statin therapy in patients with NAFLD. Read More

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http://dx.doi.org/10.1177/1179552218787502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043943PMC
July 2018
5 Reads

Successful Endoscopic Treatment of Post-esophagectomy Refractory Reflux Using OverStitch: The First Clinical Case.

Clin Med Insights Gastroenterol 2018 3;11:1179552218784946. Epub 2018 Jul 3.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Aims: The reflux of duodeno-gastric contents into the remnant esophagus (gastric tube-esophageal reflux: GTER) is a significant issues in long-term esophageal cancer survivors after radical esophagectomy. We attempted endoscopic valve (funnel) creation for prevention for GTER using OverStitch endoscopic suturing system.

Methods: The OverStitch was mounted onto a standard double-channel endoscope. Read More

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http://dx.doi.org/10.1177/1179552218784946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043920PMC
July 2018
7 Reads

Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia.

Clin Med Insights Gastroenterol 2018 18;11:1179552218778627. Epub 2018 May 18.

Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC, USA.

Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients.

Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Read More

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http://dx.doi.org/10.1177/1179552218778627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960842PMC
May 2018
6 Reads

The Morbidity and Mortality of Laparoscopic Appendectomy in Patients with Cirrhosis.

Clin Med Insights Gastroenterol 2018 11;11:1179552217746645. Epub 2018 Apr 11.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Introduction: The perioperative mortality is significantly higher in patients with cirrhosis undergoing certain surgical procedures. In this study, we examined the inpatient perioperative mortality and morbidities in cirrhotic people who underwent laparoscopic appendectomy.

Methods: We performed a retrospective analysis using the National Inpatient Sample database for 2010. Read More

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http://journals.sagepub.com/doi/10.1177/1179552217746645
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http://dx.doi.org/10.1177/1179552217746645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900807PMC
April 2018
12 Reads

Corrigendum.

Authors:

Clin Med Insights Gastroenterol 2017 26;10:1179552217722589. Epub 2017 Jul 26.

[This corrects the article DOI: 10.1177/1179552217711430.]. Read More

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http://dx.doi.org/10.1177/1179552217722589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896841PMC
July 2017
6 Reads

Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome.

Gastroenterology 2018 07 5;155(1):168-179. Epub 2018 Apr 5.

Unit of Gastrointestinal Genetics, Department of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Ikerbasque, Basque Science Foundation, Bilbao, Spain. Electronic address:

Background & Aims: Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants.

Methods: We studied 7,287,191 high-quality single nucleotide polymorphisms in individuals who self-reported a doctor's diagnosis of IBS (cases; n = 9576) compared to the remainder of the cohort (controls; n = 336,499) (mean age of study subjects, 40-69 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183040
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http://dx.doi.org/10.1053/j.gastro.2018.03.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035117PMC
July 2018
27 Reads

New Insights for Controversial Issues of miR-122 in Hepatic Lipid Metabolism.

Authors:
Hsien-Hui Chung

Gastroenterology 2018 04 8;154(5):1552-1553. Epub 2018 Mar 8.

Preventive Medicine Program, Center for General Education, Chung Yuan Christian University, Taoyuan City, Taiwan and Department of Pharmacy & Clinical Trial Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183014
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http://dx.doi.org/10.1053/j.gastro.2017.12.039DOI Listing
April 2018
23 Reads

Orbital Inflammatory Complications of Crohn's Disease: A Rare Case Series.

Clin Med Insights Gastroenterol 2018 20;11:1179552218757512. Epub 2018 Feb 20.

Nottingham Digestive Diseases Centre, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn's disease. Inflammation is characteristically nonspecific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly understood. Read More

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http://dx.doi.org/10.1177/1179552218757512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824895PMC
February 2018
13 Reads

CNCM I-745 Improves Intestinal Enzyme Function: A Trophic Effects Review.

Clin Med Insights Gastroenterol 2018 9;11:1179552217752679. Epub 2018 Feb 9.

Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium.

Several properties of the probiotic medicinal yeast CNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota, CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review. Read More

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http://dx.doi.org/10.1177/1179552217752679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808955PMC
February 2018
6 Reads

A Randomized Controlled Trial Comparing the Depth of Maximal Insertion Between Anterograde Single-Balloon Versus Spiral Enteroscopy.

Clin Med Insights Gastroenterol 2018 24;11:1179552218754881. Epub 2018 Jan 24.

Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins Medicine, Baltimore, MD, USA.

Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE.

Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events. Read More

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http://dx.doi.org/10.1177/1179552218754881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788085PMC
January 2018
25 Reads

A Case of Gastric Ulcer With Mucosal Bridge.

Clin Med Insights Gastroenterol 2017 20;10:1179552217749206. Epub 2017 Dec 20.

Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Endoscopic images of the mucosal bridge with gastric ulcer are unusual. The mucosal bridge is presumed to have changed to a special form based on repeated development of gastric ulcer. The clinical course of mucosal bridge is unclear. Read More

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http://dx.doi.org/10.1177/1179552217749206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751897PMC
December 2017
7 Reads

Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis.

Clin Med Insights Gastroenterol 2017 13;10:1179552217746692. Epub 2017 Dec 13.

Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment for ulcerative colitis (UC). Emergency colectomies are performed for fulminant colitis (ie, toxic megacolon, profuse bleeding, perforation, or sepsis). The RPC and IPAA involve manipulation of the proximal ileum, which may influence the essential physiological function of gut-associated lymphoid tissues. Read More

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http://dx.doi.org/10.1177/1179552217746692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734426PMC
December 2017
28 Reads

Insights Into the Pathophysiology of Esophageal Adenocarcinoma.

Gastroenterology 2018 01 14;154(2):406-420. Epub 2017 Oct 14.

University College London Cancer Institute, London, United Kingdom; University College London Hospital, London, United Kingdom.

Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic acid biliary reflux to Barrett's esophagus and cancer. Increasing our understanding of the mechanisms by which normal squamous epithelium progresses to early-stage invasive cancer will help formulate rational surveillance guidelines and allow us to divest resources away from patients at low risk of malignancy. We review the cellular and genetic alterations that occur during progression of Barrett's esophagus, based on findings from clinical studies and mouse models of disease. Read More

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http://dx.doi.org/10.1053/j.gastro.2017.09.046DOI Listing
January 2018
19 Reads

Should Emergency Endoscopy be Performed in All Patients With Suspected Colonic Diverticular Hemorrhage?

Clin Med Insights Gastroenterol 2017 6;10:1179552217728906. Epub 2017 Sep 6.

Department of gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Objective: We attempted to develop a scoring system for facilitating decision making regarding the performance of emergency endoscopy in patients with colonic diverticular hemorrhage.

Methods: This study involved analysis of the data of 178 patients who presented with hematochezia and were diagnosed as having colonic diverticular hemorrhage by colonoscopy. The patients were divided into 2 groups depending on whether the bleeding source was identified or not at the initial endoscopy (source-identified and source-not-identified groups), and on the basis of the results obtained, we established a scoring system for predicting successful identification of the bleeding source. Read More

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http://dx.doi.org/10.1177/1179552217728906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590691PMC
September 2017
31 Reads

Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis.

Clin Med Insights Gastroenterol 2017 31;11:1179552217729343. Epub 2017 Aug 31.

Global Health and Nutrition Sciences, DuPont Nutrition & Health, Kantvik, Finland.

Availability of normative patient outcome data may assist in designing experiments and estimating sample sizes. The purpose of this review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Constipation-Symptoms (PAC-SYM), and Patient Assessment of Constipation-Quality of Life (PAC-QOL) in adults diagnosed with functional constipation per Rome III guidelines. Pooled estimates were derived from random-effects meta-analysis. Read More

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http://dx.doi.org/10.1177/1179552217729343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582663PMC
August 2017
44 Reads

Review of Rifaximin: Latest Treatment Frontier for Irritable Bowel Syndrome Mechanism of Action and Clinical Profile.

Clin Med Insights Gastroenterol 2017 31;10:1179552217728905. Epub 2017 Aug 31.

Liver Associates of Texas, Houston, Texas, USA.

Background: Irritable bowel syndrome is classified as a functional gastrointestinal disorder with the primary symptom of abdominal pain in conjunction with bloating and bowel movement disorder. It affects up to 15% of the world's population. Among its subtypes, the most common is diarrhoea predominant. Read More

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http://dx.doi.org/10.1177/1179552217728905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582649PMC
August 2017
35 Reads

The Aftermath of a Hepatic Artery Aneurysm-A Rare Etiology of Biliary Obstruction!

Clin Med Insights Gastroenterol 2017 8;10:1179552217711430. Epub 2017 Jun 8.

Divisions of Gastroenterology and Hepatology, School of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.

Background: Hepatic artery aneurysms (HAAs) constitute 14% to 20% of visceral artery aneurysms. Most HAAs are asymptomatic. Although rare, obstructive jaundice due to external bile duct compression or rupture of the HAA into the biliary tree with occlusion of the lumen from blood clots has been reported. Read More

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http://dx.doi.org/10.1177/1179552217711430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467703PMC
June 2017
44 Reads

Functional Budd-Chiari Syndrome Associated With Severe Polycystic Liver Disease.

Clin Med Insights Gastroenterol 2017 7;10:1179552217713003. Epub 2017 Jun 7.

Divisions of Nephrology and Molecular Medicine, Department of Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.

A 50-year-old woman with end-stage renal disease secondary to autosomal dominant polycystic kidney disease was referred to a quaternary care center due to significantly increased abdominal girth. Her physical examination revealed tense ascites and abdominal collateral veins. A 10-L paracentesis improved abdominal discomfort and disclosed a transudate, suggestive of portal hypertension. Read More

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http://dx.doi.org/10.1177/1179552217713003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466357PMC
June 2017
39 Reads

Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease.

Clin Med Insights Gastroenterol 2017 31;10:1179552217709456. Epub 2017 May 31.

Department of Gastroenterology and Nutritiology, State Educational Establishment "Belarusian Medical Academy of Post-Graduate Education," Minsk, Belarus.

Aim: To compare the efficacy and safety of omeprazole-domperidone combination vs omeprazole monotherapy in gastroesophageal reflux disease (GERD).

Methods: In a comparative, randomized controlled, phase 4 study, outpatients with GERD were randomly allocated to either group 1 (omeprazole 20 mg + domperidone 30 mg) or group 2 (omeprazole 20 mg) in an equal ratio; 2 capsules daily in the morning were administered for 8 weeks.

Results: Sixty patients were enrolled. Read More

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http://dx.doi.org/10.1177/1179552217709456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457029PMC
May 2017
51 Reads

Eradication of Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium.

Clin Med Insights Gastroenterol 2016 17;9:73-78. Epub 2016 Nov 17.

Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

Introduction: We evaluated the effect of (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa.

Materials And Methods: We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication. Read More

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http://dx.doi.org/10.4137/CGast.S38330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117488PMC
November 2016
49 Reads

Diagnostic and Therapeutic Approaches to Hepatocellular Carcinoma: Understanding the Barcelona Clínic Liver Cancer Protocol.

Clin Med Insights Gastroenterol 2016 26;9:67-71. Epub 2016 Oct 26.

Resident Physician, Department of Gastroenterology, Hepatology and Digestive Endoscopy, Hospital Geral de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil; Internal Medicine, Hospital Geral de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil.

Each year, hepatocellular carcinoma is diagnosed in more than half a million people worldwide and it is the fifth most common cancer in men and the seventh most common cancer in women. This article reviews the Barcelona-Clínic Liver Cancer protocol for the diagnosis, staging, and treatment of this disease, and four cases are presented for the discussion of the therapeutic approach. Understanding the diagnostic and therapeutic approaches to this disease is essential, especially if we keep in mind the quintessential basics of prevention and early detection. Read More

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http://dx.doi.org/10.4137/CGast.S30190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084833PMC
October 2016
27 Reads

Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea.

Gastroenterology 2017 02 20;152(3):515-532.e2. Epub 2016 Oct 20.

Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California.

Chronic watery diarrhea poses a diagnostic and therapeutic challenge and is often a disabling condition for patients. Although acute diarrhea is likely to be caused by infection, the causes of chronic diarrhea (>4 weeks in duration) are more elusive. We review the pathophysiology, diagnosis, and treatment of chronic diarrhea. Read More

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http://dx.doi.org/10.1053/j.gastro.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285476PMC
February 2017
27 Reads

Primary Esophageal Intramural Squamous Cell Carcinoma Masquerading as a Submucosal Tumor: A Rare Presentation of a Common Disease.

Clin Med Insights Gastroenterol 2016 29;9:63-66. Epub 2016 Sep 29.

Professor and Head of the Department, Department of Gastroenterology, Topiwala National Medical College & BYL Nair Ch. Hospital, Mumbai, Maharashtra, India.

Esophageal squamous cell carcinoma (ESCC) is the commonest primary malignant esophageal tumor, which typically presents as endoscopically visible surface mucosal ulcerations, irregularities, or polyploidal masses. We here report a rare case of primary ESCC with completely intramural growth under a normal looking intact nondysplastic surface squamous epithelium disguising as a submucosal tumor. Upper gastrointestinal endoscopy-guided mucosal biopsy was negative for malignancy. Read More

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http://dx.doi.org/10.4137/CGast.S40605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045250PMC
September 2016
44 Reads

The Role of Laboratory Tests in Crohn's Disease.

Clin Med Insights Gastroenterol 2016 18;9:51-62. Epub 2016 Aug 18.

Trainee in Gastroenterology, Gastroenterology and Hepatology Section, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo School of Medicine, Palermo, Italy.

In the past, laboratory tests were considered of limited value in Crohn's disease (CD). In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective, to predict the response to pharmacological options and the risk of relapse, to discriminate CD from ulcerative colitis, to select candidates to anti-tumor necrosis factors [screening tests looking for hepatitis B virus and hepatitis C virus status and latent tuberculosis], to assess the risk of adverse events (testing for thiopurine metabolites and thiopurine-methyltransferase activity), and to personalize and optimize therapy (therapeutic drug monitoring). Pharmacogenetics, though presently confined to the assessment of thiopurineme methyltransferase polymorphisms and hematological toxicity associated with thiopurine treatment, is a promising field that will contribute to a better understanding of the molecular mechanisms of the variability in response to the drugs used in CD with the attempt to expand personalized care and precision medicine strategies. Read More

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http://dx.doi.org/10.4137/CGast.S38203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991576PMC
September 2016
9 Reads

Elderly Onset Celiac Disease: A Narrative Review.

Clin Med Insights Gastroenterol 2016 27;9:41-9. Epub 2016 Jul 27.

Gastroenterology and Hepatology Section, DIBIMIS, University of Palermo School of Medicine, Palermo, Italy.

Celiac sprue is a chronic disease, which usually occurs in children and young adults. However, it can develop in any age group, and the prevalence is increasing even in the elderly population. The atypical patterns of clinical presentation in this age group sometimes can cause a delay in diagnosis. Read More

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http://dx.doi.org/10.4137/CGast.S38454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965017PMC
August 2016
29 Reads

Comparing the Roles of EUS, ERCP and MRCP in Idiopathic Acute Recurrent Pancreatitis.

Clin Med Insights Gastroenterol 2016 20;9:35-9. Epub 2016 Jun 20.

Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.

Acute recurrent pancreatitis (ARP) is defined as more than two attacks of acute pancreatitis with complete or almost complete resolution of symptoms and signs of pancreatitis between episodes. The initial evaluation fails to detect the cause of ARP in 10%-30% of patients, whose condition is classified as idiopathic ARP. Endoscopic ultrasound (EUS) has gained increasing attention as a useful imaging modality for the pancreas and the extrahepatic biliary tree. Read More

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http://dx.doi.org/10.4137/CGast.S37927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915784PMC
July 2016
17 Reads

Internal Herniation Through Foramen of Winslow: A Diagnosis Not to Be Missed.

Clin Med Insights Gastroenterol 2016 12;9:31-3. Epub 2016 Jun 12.

Wye Valley NHS Trust, Hereford, UK.

Introduction: Hernias through the foramen of Winslow are extremely rare, accounting for 0.1% of all abdominal hernias. Delayed diagnosis is often observed, resulting in bowel strangulation and high mortality. Read More

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http://dx.doi.org/10.4137/CGast.S38453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907339PMC
June 2016
17 Reads

Primary Sclerosing Cholangitis: Therapeutic Options and Surveillance Management.

Clin Med Insights Gastroenterol 2016 9;9:25-9. Epub 2016 Jun 9.

University Hospital North Midlands, Stoke-on-Trent, England, UK.

Primary sclerosing cholangitis is a chronic immune-mediated liver disease. Though rare, it poses several clinical concerns for the managing physician. There are currently limited therapeutic options in the management of the condition and weak evidence base behind them. Read More

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http://dx.doi.org/10.4137/CGast.S38451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902039PMC
June 2016
20 Reads

Palliation of Dysphagia in Carcinoma Esophagus.

Clin Med Insights Gastroenterol 2016 6;9:11-23. Epub 2016 Jun 6.

Assistant Professor, Department of Medical Oncology, Jawaharlal Institute of Postgraduation Medical Education & Research (JIPMER), Puducherry, India.

Esophageal carcinoma has a special place in gastrointestinal carcinomas because it contains two main types, namely, squamous cell carcinoma and adenocarcinoma. Carcinoma esophagus patients require some form of palliation because of locally advanced stage or distant metastasis, where it cannot be subjected to curable treatment with surgery and chemoradiation. Many modalities of palliation of dysphagia are available, but the procedure with least morbidity, mortality, and long-term palliation of dysphagia needs to be chosen for the patient. Read More

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http://dx.doi.org/10.4137/CGast.S30303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896534PMC
June 2016
6 Reads

Gastric Hamartomatous Polyps-Review and Update.

Clin Med Insights Gastroenterol 2016 7;9:3-10. Epub 2016 Apr 7.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Gastric polyps are frequently encountered on endoscopic examinations. While many of these represent true epithelial lesions, some of the polyps may result from underlying stromal or lymphoid proliferations or even heterotopic tissue. Histologic examination is essential for accurate typing of the polyps to predict malignant potential and underlying possible genetic abnormalities. Read More

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http://dx.doi.org/10.4137/CGast.S38452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825775PMC
April 2016
8 Reads

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.

Gastroenterology 2016 Jun 23;150(8):1756-68. Epub 2016 Feb 23.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Alcoholic liver disease (ALD) develops in approximately 20% of alcoholic patients, with a higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte necrosis, as well as apoptosis, inflammation, regenerating nodules, fibrosis, and cirrhosis.(1) ALD develops via a complex process involving parenchymal and nonparenchymal cells, as well as recruitment of other cell types to the liver in response to damage and inflammation. Read More

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http://dx.doi.org/10.1053/j.gastro.2016.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887335PMC
June 2016
22 Reads
23 Citations
16.720 Impact Factor

"Pinstripe Pattern" in an Achalasia Patient.

Clin Med Insights Gastroenterol 2016 18;9:1-2. Epub 2016 Jan 18.

Department of Gastroenterology, Mitoyo General Hospital, Kagawa, Japan.

Endoscopic image of achalasia usually shows dilated esophageal cavity with retained liquids and foods. Recently, "pinstripe pattern" (PSP) in the case of achalasia patient was reported as an endoscopic image of the indicator for early detection of achalasia. The typical endoscopic image of PSP can be recognized in this case. Read More

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http://dx.doi.org/10.4137/CGast.S34258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718084PMC
January 2016
20 Reads

Hemostasis Achieved Endoscopically for Diverticular Bleeding from the Horizontal Portion of the Duodenum.

Clin Med Insights Gastroenterol 2015 6;8:61-4. Epub 2015 Dec 6.

Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki, Japan.

Diverticulum of the horizontal portion of the duodenum is a rare cause of upper gastrointestinal (GI) bleeding. Since it is difficult to access the horizontal portion of the duodenum by standard upper GI endoscopy, only a very few cases of endoscopic hemostasis have been reported. Herein, we report a case of diverticular bleeding from the horizontal portion of the duodenum for which hemostasis was achieved using a small-caliber colonoscope, which has an insertion part designed with a passive-bending function/high-force transmission and a transparent tip hood. Read More

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http://dx.doi.org/10.4137/CGast.S32421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671547PMC
December 2015
25 Reads

Bioelectrical Stimulation for the Reduction of Inflammation in Inflammatory Bowel Disease.

Clin Med Insights Gastroenterol 2015 6;8:55-9. Epub 2015 Dec 6.

Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA. ; Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA. ; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA.

Crohn's disease and ulcerative colitis are the primary inflammatory bowel diseases (IBDs) affecting the gastrointestinal tract. The current therapy aims at decreasing inflammation and reducing symptoms. This typically requires immune suppression by steroids, thiopurines, methotrexate, or tumor necrosis factor inhibitors. Read More

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http://dx.doi.org/10.4137/CGast.S31779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671545PMC
December 2015
14 Reads

Factors Associated with Hepatitis C Knowledge Before and After an Educational Intervention among Vietnamese Americans.

Clin Med Insights Gastroenterol 2015 29;8:45-53. Epub 2015 Oct 29.

Department of Public Health, Center for Asian Health, College of Public Health, Temple University, Philadelphia, PA, USA.

Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease and cancer. Vietnamese Americans are at high risk of HCV infection, with men having the highest US incidence of liver cancer. This study examines an intervention to improve HCV knowledge among Vietnamese Americans. Read More

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http://dx.doi.org/10.4137/CGast.S24737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629630PMC
November 2015
51 Reads

Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides.

Clin Med Insights Gastroenterol 2015 6;8:29-44. Epub 2015 May 6.

Laboratory of Inflammatory Bowel Disease Research, Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, Nashville, Tennessee. ; Department of General Surgery, Colon and Rectal Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee. ; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Background: As accessible diagnostic approaches fail to differentiate between ulcerative colitis (UC) and Crohn's colitis (CC) in one-third of patients with predominantly colonic inflammatory bowel disease (IBD), leading to inappropriate therapy, we aim to investigate the serum cytokine levels in these patients in search of molecular biometric markers delineating UC from CC.

Methods: We measured 38 cytokines, chemokines, and growth factors using magnetic-bead-based multiplex immunoassay in 25 UC patients, 28 CC patients, and 30 controls. Our results are compared with those from a review of current literature regarding advances in serum cytokine profiles and associated challenges preventing their use for diagnostic/prognostic purposes. Read More

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http://dx.doi.org/10.4137/CGast.S20612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459555PMC
June 2015
68 Reads

Is ESR Important for Predicting Post-ERCP Pancreatitis?

Clin Med Insights Gastroenterol 2015 5;8:23-7. Epub 2015 May 5.

Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.

Background: Pancreatitis remains the most common complication of endoscopic retrograde cholangiopancreatography (ERCP), resulting in substantial morbidity and occasional mortality. There are notable controversies and conflicting reports about risk factors of post-ERCP pancreatitis (PEP).

Aim: To evaluate the potential risk factors for PEP at a referral tertiary center, as a sample of the Iranian population. Read More

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http://dx.doi.org/10.4137/CGast.S18938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426942PMC
May 2015
21 Reads