82 results match your criteria Clinical Medicine Insights: Endocrinology and Diabetes [Journal]


The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity.

Authors:
Naohiko Ueno

Clin Med Insights Endocrinol Diabetes 2019 22;12:1179551418825049. Epub 2019 Jan 22.

Ueno Internal Medicine and Diabetes Clinic, Kobe, Japan.

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity.

Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B (n = 12) were retrospectively evaluated. Read More

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http://dx.doi.org/10.1177/1179551418825049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343451PMC
January 2019
1 Read

Adrenocorticotropic Hormone-Dependent Cushing Syndrome Caused by an Olfactory Neuroblastoma.

Clin Med Insights Endocrinol Diabetes 2019 31;12:1179551419825832. Epub 2019 Jan 31.

Department of Endocrinology, Hospital Clinico San Carlos, Madrid, Spain.

Olfactory neuroblastoma (ONB) is an unusual malignant neoplasm originating from the olfactory neuroepithelium. Secretion of adrenocorticotropic hormone (ACTH) from this tumor has been exceptionally reported. We describe a young man with resistant hypertension and a cushingoid phenotype. Read More

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http://dx.doi.org/10.1177/1179551419825832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357293PMC
January 2019
1 Read

Glycemic Control in Children and Youth With Type 1 Diabetes Mellitus in Saudi Arabia.

Clin Med Insights Endocrinol Diabetes 2019 24;12:1179551418825159. Epub 2019 Jan 24.

Endocrine Division, Department of Pediatrics, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Objective: To determine the glycemic control and cardio-metabolic complications of children and adolescents with type 1 diabetes mellitus (T1DM) attending a tertiary care diabetes clinic in Saudi Arabia.

Methods: We conducted a retrospective cross-sectional study of children and adolescents with T1DM attending King Abdulaziz Medical City-Jeddah from 2010 to 2013. We assessed their glycemic control and diabetes management. Read More

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http://dx.doi.org/10.1177/1179551418825159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348502PMC
January 2019
14 Reads

Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism Is Not Responsible for Antihypertensive Therapy Induced New Onset of Type 2 Diabetes in Essential Hypertension.

Clin Med Insights Endocrinol Diabetes 2019 23;12:1179551418825037. Epub 2019 Jan 23.

Maharishi Markandeshwar University, Solan, India.

Background: Antihypertensive drug therapies have been reported to be associated with new onset of type 2 diabetes mellitus in some hypertensive patients after prolonged use. Angiotensin converting enzyme (ACE) gene has been found to affect essential hypertension, response of antihypertensive therapies, and glycemic disturbances. Therefore, ACE gene I/D polymorphism may be associated with risk of new onset of type 2 diabetes via metabolic disturbances, glycemic dysregulation, and insulin resistance. Read More

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http://dx.doi.org/10.1177/1179551418825037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348549PMC
January 2019
1 Read

Why Is Hyperparathyroidism Underdiagnosed and Undertreated in Older Adults?

Clin Med Insights Endocrinol Diabetes 2018 12;11:1179551418815916. Epub 2018 Dec 12.

Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Hyperparathyroidism significantly decreases quality of life, yet elderly patients are underdiagnosed and undertreated even though parathyroidectomy offers definitive cure with minimal morbidity. The purpose of this study is to determine why older patients with hyperparathyroidism are not appropriately diagnosed and referred for parathyroidectomy.

Methods: We reviewed charts for a random sample of 25 patients aged 75 and older who had hyperparathyroidism and were referred for surgical evaluation, and 25 who were not referred. Read More

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http://dx.doi.org/10.1177/1179551418815916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291858PMC
December 2018
1 Read

Gene Screening and Association of Variants With Gestational Diabetes in North Indian Population.

Clin Med Insights Endocrinol Diabetes 2018 26;11:1179551418806896. Epub 2018 Oct 26.

Institute of Endocrinology, Diabetes & Metabolism, Max Healthcare Institute Ltd., New Delhi, India.

Background: gene variants have been reported to be associated with gestational diabetes mellitus (GDM) in the Caucasian population. There are no reports exploring this association in the Indian population.

Methods: This cross-sectional study included subjects from Max Super Speciality Hospital, New Delhi, India, over a span of 6 months. Read More

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http://dx.doi.org/10.1177/1179551418806896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204622PMC
October 2018
10 Reads

Skin-Related Complications Among Adolescents With Type 1 Diabetes Using Insulin Pump Therapy.

Clin Med Insights Endocrinol Diabetes 2018 5;11:1179551418798794. Epub 2018 Sep 5.

Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background: To identify the skin-related complications in adolescents with type 1 diabetes (T1D) using the insulin pump therapy (IPT).

Methods: A total of 64 T1D adolescents (between ages 13 and 19) using the insulin pump were included in this cross-sectional study. They had visited the Diabetes Clinic at Diabetes Treatment Center, Prince Sultan Military Medical City, Saudi Arabia, for treatment from January 2018 to March 2018. Read More

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http://dx.doi.org/10.1177/1179551418798794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125850PMC
September 2018
15 Reads

The Impact of Insulin Resistance and Chronic Kidney Disease on Inflammation and Cardiovascular Disease.

Clin Med Insights Endocrinol Diabetes 2018 1;11:1179551418792257. Epub 2018 Aug 1.

Division of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, NY, USA.

There is extensive evidence showing that insulin resistance (IR) is associated with chronic low-grade inflammation. Furthermore, IR has been shown to increase the risk for cardiovascular disease (CVD), even in nondiabetic patients, and is currently considered as a "nontraditional" risk factor contributing to CVD by promoting hypertension, oxidative stress, endothelial dysfunction, dyslipidemia, and type 2 diabetes mellitus. However, chronic kidney disease (CKD) is also considered a state of low-grade inflammation. Read More

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http://dx.doi.org/10.1177/1179551418792257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071166PMC
August 2018
2 Reads

Combination of Empagliflozin and Metformin Therapy: A Consideration of its Place in Type 2 Diabetes Therapy.

Clin Med Insights Endocrinol Diabetes 2018 10;11:1179551418786258. Epub 2018 Jul 10.

School of Pharmacy, MCPHS University, Boston, MA, USA.

Type 2 diabetes mellitus (T2DM) is characterized by multiple metabolic abnormalities and current approaches to treatment involve a stepwise approach, frequently involving the use of combination therapy. The addition of the sodium-glucose cotransporter-2 (SGLT2) inhibitor, empagliflozin, to metformin therapy has been shown to be effective and well tolerated in patients with T2DM and is 1 of the several recommended treatment options. The publication of the EMPA-REG OUTCOME study, which showed that empagliflozin is associated with cardiovascular (CV) and renal benefits, has resulted in changes in treatment guidelines for T2DM. Read More

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http://dx.doi.org/10.1177/1179551418786258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043932PMC
July 2018
6 Reads

Should Symptoms Be Considered an Indication for Parathyroidectomy in Primary Hyperparathyroidism?

Clin Med Insights Endocrinol Diabetes 2018 27;11:1179551418785135. Epub 2018 Jun 27.

Division of Endocrine Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.

Asymptomatic primary hyperparathyroidism is a very common endocrine condition, yet management of this disease process remains controversial. Primary hyperparathyroidism can lead to a myriad of symptoms which not only decreases the quality of life of patients but also increases the risk of cardiovascular disease, osteoporosis, and kidney stones. Parathyroidectomy is the only known cure for the disease. Read More

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http://dx.doi.org/10.1177/1179551418785135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043916PMC
June 2018
3 Reads

Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors.

Clin Med Insights Endocrinol Diabetes 2018 21;11:1179551418759076. Epub 2018 Mar 21.

Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Background: Graves disease (GD) has increased in prevalence over the past decade in Africa. Despite this, the condition is not well described, especially in sub-Saharan Africa.

Objective: We have described the clinical characteristics and associated factors of GD in a cohort of patients attending a resource-limited setting tertiary hospital. Read More

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http://dx.doi.org/10.1177/1179551418759076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865516PMC
March 2018
10 Reads

Cabergoline-Induced Pneumocephalus Following Treatment for Giant Invasive Macroprolactinoma Presenting With Spontaneous Cerebrospinal Fluid Rhinorrhea.

Clin Med Insights Endocrinol Diabetes 2018 13;11:1179551418758640. Epub 2018 Feb 13.

Obesity, Endocrine, and Metabolism Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Cerebrospinal fluid (CSF) rhinorrhea is rarely reported as the first presenting feature of giant invasive macroprolactinomas. Cerebrospinal fluid rhinorrhea is usually reported as a complication of trauma, neurosurgical, and skull-based procedures (such as pituitary surgery or radiations), and less frequently after medical treatment with dopamine agonists (DAs) for macroprolactinomas. This phenomenon results from fistula creation that communicates between the subarachnoid space and the nasal cavity. Read More

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http://dx.doi.org/10.1177/1179551418758640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815410PMC
February 2018
36 Reads

Assessment of Ramadan Education and Knowledge Among Diabetic Patients.

Clin Med Insights Endocrinol Diabetes 2018 10;11:1179551417751611. Epub 2018 Jan 10.

Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: During Ramadan, Muslims fast from dawn until dusk for one lunar month every year. Most of the Muslim patients with diabetes are unaware of the potential complications that can occur while fasting, such as hypoglycemia. The aim of this study is to assess the the patient education level and patients' overall awareness of any possible complications that could occur while fasting during Ramadan and to determine how these patients deal with these complications. Read More

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http://dx.doi.org/10.1177/1179551417751611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768264PMC
January 2018
4 Reads

Microvascular Outcomes of Pediatric-Onset Type 1 Diabetes Mellitus: A Single-Center Observational Case Reviews in Sana'a, Yemen.

Clin Med Insights Endocrinol Diabetes 2018 3;11:1179551417749217. Epub 2018 Jan 3.

Department of Medicine, Sana'a University, Sana'a, Yemen.

Microvascular complications of pediatric-onset type 1 diabetes are common in low-income countries. In this study, we aimed at reviewing microvascular outcomes in 6 cases with type 1 diabetes over 14 to 31 years of follow-up. Severe proliferative diabetic retinopathy (PDR) and/or diabetic macular edema (maculopathy) (DME) and overt diabetic nephropathy (macroalbuminuria) were seen among 4 of 6 patients, whereas severe diabetic peripheral neuropathy with Charcot neuroarthropathy was seen in 1 patient only, who had the longest duration of follow-up. Read More

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http://dx.doi.org/10.1177/1179551417749217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757421PMC
January 2018
9 Reads

Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status.

Clin Med Insights Endocrinol Diabetes 2018 3;11:1179551417748942. Epub 2018 Jan 3.

Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.

The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. Read More

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http://dx.doi.org/10.1177/1179551417748942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757425PMC
January 2018
5 Reads

Evaluation of FreeStyle Libre Flash Glucose Monitoring System on Glycemic Control, Health-Related Quality of Life, and Fear of Hypoglycemia in Patients with Type 1 Diabetes.

Clin Med Insights Endocrinol Diabetes 2017 10;10:1179551417746957. Epub 2017 Dec 10.

Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background/objectives: In the current era of modern technology and the development of smart devices such as the flash glucose monitoring (FGM) systems, patients can easily monitor their glucose levels more frequently without any inconvenience. In this study, we evaluate the effect of FreeStyle Libre FGM system on glycemic control, hypoglycemia, health-related quality of life (QoL), and the fear of hypoglycemia (FOH) among children and young people with type 1 diabetes (T1D).

Design And Methods: A prospective study was conducted at the Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia, between January 2017 and May 2017 on 47 (aged 13-19 years) registered patients with T1D who used conventional finger-pricking method for self-testing the glucose. Read More

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http://dx.doi.org/10.1177/1179551417746957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731614PMC
December 2017
44 Reads

Active Stromal Cell-Derived Factor 1α and Endothelial Progenitor Cells are Equally Increased by Alogliptin in Good and Poor Diabetes Control.

Clin Med Insights Endocrinol Diabetes 2017 27;10:1179551417743980. Epub 2017 Nov 27.

Faculty of Medicine, San Raffaele Hospital, Milano, Italy.

Background: It is postulated that the ability of dipeptidyl peptidase-4 inhibitors (DPP-4-i) to increase circulating endothelial progenitor cells (EPCs) may be at least partly mediated by active stromal cell-derived factor 1α (SDF-1α) (a pivotal mediator of stem cell mobilization from the bone marrow). As other DPP-4-i were demonstrated to increase EPC concentrations, in this study, we sought to investigate the ability of the DPP-4-i alogliptin in modifying EPCs and SDF-1α, in patients with good and poor diabetes control.

Methods: Two groups of diabetic patients on metformin were divided by hemoglobin A (HbA): Group A-those with HbA ≤6. Read More

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http://dx.doi.org/10.1177/1179551417743980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714079PMC
November 2017
6 Reads

Insulinoma and Chronic Kidney Disease: An Uncommon Conundrum Not to Be Overlooked.

Clin Med Insights Endocrinol Diabetes 2017 20;10:1179551417742620. Epub 2017 Nov 20.

Department of Internal Medicine, Galliera Hospital, Genova, Italy.

A hypertensive man with chronic kidney disease (CKD) secondary to polycystic disease was hospitalized for symptoms related to hypoglycemia. Fasting test elicited symptomatic hypoglycemia after 12 hours, which was associated with inappropriately unsuppressed normal insulin and C-peptide levels. Neither ultrasonography (US) nor magnetic resonance imaging detected any pancreatic tumor. Read More

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http://dx.doi.org/10.1177/1179551417742620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700780PMC
November 2017
11 Reads

Erratum.

Authors:

Clin Med Insights Endocrinol Diabetes 2017 10;10:1179551417722086. Epub 2017 Oct 10.

[This corrects the article DOI: 10.1177/1179551417710209.]. Read More

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http://dx.doi.org/10.1177/1179551417722086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637963PMC
October 2017
7 Reads

Association of Angiotensin-Converting Enzyme Gene Polymorphisms and Nephropathy in Diabetic Patients at a Tertiary Care Centre in South India.

Clin Med Insights Endocrinol Diabetes 2017 29;10:1179551417726779. Epub 2017 Aug 29.

Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Background: Genetic polymorphisms of the angiotensin-renin pathway have been thought to influence the development of diabetic nephropathy. However, there are conflicting results regarding this association in previous studies on populations with varying ethnicity.

Aims: Primary aim was to compare the frequency of distribution of angiotensin-converting enzyme () gene (insertion/deletion [I/D]) polymorphism in Tamilian Indian type 2 diabetic individuals with and without microalbuminuria. Read More

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http://dx.doi.org/10.1177/1179551417726779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580844PMC
August 2017
8 Reads

Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature.

Clin Med Insights Endocrinol Diabetes 2017 6;10:1179551417712521. Epub 2017 Jun 6.

Clínica de Endocrinología y Metabolismo, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. Read More

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http://dx.doi.org/10.1177/1179551417712521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462550PMC
June 2017
22 Reads

Assessment of Hypogonadism in Men With Type 2 Diabetes: A Cross-Sectional Study From Saudi Arabia.

Clin Med Insights Endocrinol Diabetes 2017 19;10:1179551417710209. Epub 2017 May 19.

Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background/objectives: A high incidence of hypogonadism in men with type 2 diabetes (T2D) has been globally reported. This study aimed to determining the frequency of hypogonadism and related risk factors among men with T2D in a single-site hospital in Saudi Arabia.

Design And Methods: A cross-sectional study was performed on 157 men with T2D (between 30 and 70 years of age). Read More

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http://dx.doi.org/10.1177/1179551417710209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439570PMC
May 2017
30 Reads

Genotype-Phenotype Correlation in Patients With Germline Mutations of , and Genes: Thai Experience.

Clin Med Insights Endocrinol Diabetes 2017 20;10:1179551417705122. Epub 2017 Apr 20.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Mutations in the , and genes are responsible for von Hippel-Lindau (VHL) disease, multiple endocrine neoplasia type 2 (MEN2), and familial paraganglioma, respectively. However, genotype-phenotype correlation data are lacking in Southeast Asia. A retrospective medical chart review was performed on patients referred to the genetics service. Read More

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http://dx.doi.org/10.1177/1179551417705122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404897PMC
April 2017
28 Reads

Intrathyroidal Parathyroid Cyst: An Unusual Neck Mass.

Clin Med Insights Endocrinol Diabetes 2017 16;10:1179551417698135. Epub 2017 Mar 16.

Obesity, Endocrine and Metabolism Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Parathyroid cyst (PC) is a very rare condition. A case of intrathyroidal PC is being reported here in a 53-year-old woman who presented to the endocrine clinic with slowly progressive painless left anterior neck swelling for 1 year with no symptoms of thyroid or parathyroid dysfunction and no compressive symptoms. Ultrasound of the thyroid showed a well-defined cystic lesion measuring 4. Read More

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http://journals.sagepub.com/doi/10.1177/1179551417698135
Publisher Site
http://dx.doi.org/10.1177/1179551417698135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392106PMC
March 2017
17 Reads

Slipped Capital Femoral Epiphysis and Primary Hyperparathyroidism: A Case Report.

Clin Med Insights Endocrinol Diabetes 2016 23;9:73-76. Epub 2016 Nov 23.

Faculty of Medicine, King Saud Bin Abdul-Aziz University for Health Sciences (KSAU-HS), King Fahad Medical City, Riyadh, Saudi Arabia.; Obesity, Endocrine and Metabolic Center, King Fahad Medical City, Riyadh, Saudi Arabia.

The aim of reporting this case is to highlight the association of two disorders, primary hyperparathyroidism (PHPT) and slipped capital femoral epiphysis (SCFE). They are usually seen in two different age groups and rarely together. PHPT is a rare cause of SCFE and only 10 cases have been reported in the literature worldwide. Read More

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http://journals.sagepub.com/doi/10.4137/CMED.S40895
Publisher Site
http://dx.doi.org/10.4137/CMED.S40895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123767PMC
November 2016
8 Reads

Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?

Clin Med Insights Endocrinol Diabetes 2016 12;9:47-71. Epub 2016 Oct 12.

Research and Development, Medical Center Foltra, 15886-Teo, Spain.

In this review, we analyze the effects of growth hormone on a number of tissues and organs and its putative role in the longitudinal growth of an organism. We conclude that the hormone plays a very important role in maintaining the homogeneity of tissues and organs during the normal development of the human body or after an injury. Its effects on growth do not seem to take place during the fetal period or during the early infancy and are mediated by insulin-like growth factor I (IGF-I) during childhood and puberty. Read More

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http://dx.doi.org/10.4137/CMED.S38201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063841PMC
October 2016
8 Reads

Hyperglycemia: A Predictor of Death in Severe Head Injury Patients.

Clin Med Insights Endocrinol Diabetes 2016 26;9:43-46. Epub 2016 Sep 26.

Associated Professor, Department of Neurosurgery, Diabetes Research Center, Emam Hospital, Diabetes Research Center, Mazandaran University of Medical Science, Sari, Iran.

Objectives: Management of hyperglycemia during an acute sickness in adults is accompanied by improved outcomes. We have designed a prospective study with meticulous attention to exclude all diabetes patients by checking hemoglobin A1c (HbA1c or glycated hemoglobin) to avoid the ill-effects of hyperglycemia in patients with traumatic head injury admitted to the intensive care unit (ICU).

Methods: This prospective study included adults with traumatic primary brain injury with a Glasgow coma score of ≤8 necessitating mechanical ventilation treated in the period 2012-2015. Read More

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http://dx.doi.org/10.4137/CMED.S40330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038612PMC
September 2016
6 Reads

Vitamin D Deficiency Is Associated with Severity of Acute Coronary Syndrome in Patients with Type 2 Diabetes and High Rates of Sun Exposure.

Clin Med Insights Endocrinol Diabetes 2016 1;9:37-41. Epub 2016 Sep 1.

Division of Endocrinology, Diabetes and.

Background: Vitamin D deficiency has been associated with cardiovascular risk factors, including type 2 diabetes mellitus (T2DM). Evidence shows that patients with low serum 25-hydroxyvitamin D (25OHD) concentrations have a higher risk of developing coronary artery disease.

Objective: The objective of this study was to assess vitamin D as a predictor of the severity in diabetics with acute coronary syndrome (ACS). Read More

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http://dx.doi.org/10.4137/CMED.S39427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010093PMC
September 2016
7 Reads

No Postoperative Adrenal Insufficiency in a Patient with Unilateral Cortisol-Secreting Adenomas Treated with Mifepristone Before Surgery.

Clin Med Insights Endocrinol Diabetes 2016 26;9:31-6. Epub 2016 Jul 26.

Albany Medical Center Division of Community Endocrinology, Albany, NY, USA.

Background: Glucocorticoid replacement is commonly required to treat secondary adrenal insufficiency after surgical resection of unilateral cortisol-secreting adrenocortical adenomas. Here, we describe a patient with unilateral cortisol-secreting adenomas in which the preoperative use of mifepristone therapy was associated with recovery of the hypothalamic-pituitary-adrenal (HPA) axis, eliminating the need for postoperative glucocorticoid replacement.

Case Presentation: A 66-year-old Caucasian man with type 2 diabetes mellitus, hyperlipidemia, hypertension, and obesity was hospitalized for Fournier's gangrene and methicillin-resistant Staphylococcus aureus sepsis. Read More

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http://dx.doi.org/10.4137/CMED.S39997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962955PMC
August 2016
21 Reads

Changes in Characteristics and Treatment Patterns of Patients with Newly Diagnosed Type 2 Diabetes in a Large United States Integrated Health System between 2008 and 2013.

Clin Med Insights Endocrinol Diabetes 2016 30;9:23-30. Epub 2016 Jun 30.

Endocrinology, Cleveland Clinic, Cleveland, OH, USA.

To assess changes in the clinical characteristics and treatment patterns of patients with newly diagnosed type 2 diabetes (T2D), the electronic health record system at Cleveland Clinic was used to create cross-sectional summaries of all patients with new-onset T2D in 2008 and 2013. Differences between the 2008 and 2013 data sets were assessed after adjusting for age, gender, race, and income. Approximately one-third of patients with newly diagnosed T2D in 2008 and 2013 had an A1C ≥8%, suggesting the continued presence of a delayed recognition of the disease. Read More

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http://dx.doi.org/10.4137/CMED.S39761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930160PMC
July 2016
20 Reads

Screening for Type II Diabetes Mellitus in the United States: The Present and the Future.

Clin Med Insights Endocrinol Diabetes 2016 13;9:19-22. Epub 2016 Jun 13.

Department of Family and Community Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.

The number of individuals being diagnosed with type II diabetes in the United States is increasing. The screening tests for diabetes are able to detect the vast majority of diabetics. However, they do not represent the high-risk individuals who may be prone to diabetes at an earlier age. Read More

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http://dx.doi.org/10.4137/CMED.S38247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907337PMC
June 2016
5 Reads

Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients-Is This Applicable in Saudi Patients?

Clin Med Insights Endocrinol Diabetes 2016 8;9:13-7. Epub 2016 Jun 8.

Saudi Diabetes Research Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.

Aim: To compare the effect of different treatment regimens (oral hypoglycemic agents [OHGs], insulin therapy, and combination of both) on glycemic control and other cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) patients in Saudi.

Subjects And Methods: Patients with T2DM, but no serious diabetic complications, were randomly recruited from the diabetes clinics at two large hospitals in Jeddah, Saudi Arabia, during June 2013 to July 2014. Only those without change in treatment modality for the last 18 months were included. Read More

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http://dx.doi.org/10.4137/CMED.S38077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900823PMC
June 2016
19 Reads

Clinical and Biochemical Characteristics of Diabetes Ketoacidosis in a Tertiary Hospital in Riyadh.

Clin Med Insights Endocrinol Diabetes 2016 18;9:7-11. Epub 2016 May 18.

King Abdulaziz Medical City, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Diabetes is the fifth leading cause of death worldwide. Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes. The aim of this study is to investigate the clinical and biochemical characteristics of DKA among 400 patients admitted to hospital, most of whom had type 1 diabetes (n = 372; 93%). Read More

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http://dx.doi.org/10.4137/CMED.S39639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874741PMC
May 2016
11 Reads

Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case-Control Study.

Clin Med Insights Endocrinol Diabetes 2016 5;9:1-5. Epub 2016 May 5.

School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: This study aimed to determine the prevalence of diabetes mellitus in patients with spinal stenosis and lumbar vertebral disk degeneration, and the correlation of diabetes with these diseases.

Study Design: This is a cross-sectional study.

Methods: This case-control study was performed during 2012-2014 with 110 patients suffering from lumbar spinal stenosis and 110 patients with lumbar disk herniation, who were diagnosed using clinical and radiological evidences. Read More

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http://dx.doi.org/10.4137/CMED.S39035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859445PMC
May 2016
7 Reads

Genetically Targeted Dipeptidyl Peptidase-4 Inhibitor Use in a Patient with a Novel Mutation of MODY type 4.

Clin Med Insights Endocrinol Diabetes 2015 27;8:83-6. Epub 2015 Oct 27.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA. ; VA Nebraska-Western Iowa Health Care System, University of Nebraska Medical Center, Omaha, NE, USA.

Maturity onset diabetes of the young (MODY) is a rare form of diabetes mellitus typically seen in young adults that results from pancreatic beta-cell dysfunction. MODY4 is a rare subtype caused by a PDX1 mutation. In this case, we present a nonobese 26-year-old male with polyuria and polydipsia. Read More

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http://dx.doi.org/10.4137/CMED.S31926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624095PMC
November 2015
12 Reads

Canagliflozin Treatment in Patients with Type 2 Diabetes Mellitus.

Clin Med Insights Endocrinol Diabetes 2015 18;8:73-81. Epub 2015 Oct 18.

Midwestern University, Chicago College of Pharmacy, Chicago, IL, USA.

Current guidelines for treatment of type 2 diabetes mellitus (T2DM) indicate a patient-centered approach that should go beyond glycemic control. Of the many antihyperglycemic agents available for treatment of T2DM, sodium-glucose cotransporter 2 (SGLT2) inhibitors offer the advantages of reduced glycated hemoglobin (A1C), body weight (BW), and systolic blood pressure (SBP) and are associated with a low risk of hypoglycemia when used either as monotherapy or with other agents not typically associated with increased risk of hypoglycemia. Collaborative, multidisciplinary teams are best suited to provide care to patients with diabetes, and clinical pharmacists can enhance the care provided by these teams. Read More

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http://journals.sagepub.com/doi/10.4137/CMED.S31526
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http://dx.doi.org/10.4137/CMED.S31526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610726PMC
November 2015
19 Reads

Effectiveness of Liraglutide in Type II Diabetes Mellitus Management: Experience in Emirati Patients.

Clin Med Insights Endocrinol Diabetes 2015 20;8:67-72. Epub 2015 Sep 20.

Department of Endocrinology, Zayed Military Hospital, Abu Dhabi, United Arab Emirates.

Objective: To measure effectiveness of liraglutide in reducing glycated hemoglobin (HbA1C), weight, and systolic blood pressure (SBP) in Emirati patients.

Design: A retrospective cohort study.

Setting: Endocrinology clinic in a 300-bed military hospital. Read More

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http://dx.doi.org/10.4137/CMED.S31756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578557PMC
October 2015
13 Reads

Parathyroidectomy Ameliorates Glucose and Blood Pressure Control in a Patient with Primary Hyperparathyroidism, Type 2 Diabetes, and Hypertension.

Clin Med Insights Endocrinol Diabetes 2015 2;8:63-6. Epub 2015 Sep 2.

Saraswathi Institute of Medical Sciences (SIMS), Hapur, UP, India.

Effect of parathyroidectomy on glucose control and hypertension is controversial. Here, we report a case of a patient with primary hyperparathyroidism, type 2 diabetes mellitus, and hypertension in whom parathyroidectomy ameliorated both glucose control and blood pressure. Once high serum calcium levels were noticed, ultrasonography of neck confirmed a well-defined oval hypoechoic mass posterior to the right lobe of the thyroid, confirmed by scintiscan. Read More

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http://journals.sagepub.com/doi/10.4137/CMED.S31292
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http://dx.doi.org/10.4137/CMED.S31292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559184PMC
September 2015
9 Reads

Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes.

Clin Med Insights Endocrinol Diabetes 2015 19;8:55-62. Epub 2015 Jul 19.

Department of Diagnostic Radiology, Faculty of Medicine for Boys, Al-Azhar University, Egypt.

Background: The association between type 2 diabetes mellitus (T2DM) and low total serum testosterone (LST) has been identified in several cross-sectional studies.

Objectives: To assess the prevalence of androgen deficiency and erectile dysfunction (ED) and their relation to glycemic control within a sample of Egyptian men with T2DM.

Research Design And Methods: A cross-sectional study including 70 men having T2DM. Read More

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http://dx.doi.org/10.4137/CMED.S27700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509465PMC
August 2015
8 Reads

Effect of Habitual Khat Chewing on Glycemic Control, Body Mass Index, and Age at Diagnosis of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen.

Clin Med Insights Endocrinol Diabetes 2015 2;8:47-53. Epub 2015 Jun 2.

Department of Medicine, Sana'a University Medical School, Sana'a, Yemen.

Khat chewing is common in Yemen. We conducted this study to see if it affected diabetes control in patients with type 2 diabetes mellitus (DM). We studied 1540 patients with type 2 DM attending an endocrinology clinic in Sana'a, Yemen, of which 997 were khat chewers (KC) and 543 were non-khat chewers (NKC). Read More

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http://dx.doi.org/10.4137/CMED.S26045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455697PMC
June 2015
5 Reads

Changes in the prevalence of diabetes mellitus in bulgaria (2006-2012).

Clin Med Insights Endocrinol Diabetes 2015 12;8:41-5. Epub 2015 May 12.

Medical University of Sofia, University Hospital of Endocrinology, Clinic of Thyroid and Metabolic Bone Disorders, Sofia, Bulgaria.

Aim: The aim of this study was to compare two nationwide cross-sectional studies of diabetes prevalence in Bulgaria (2006 and 2012) and to assess its dynamics.

Material And Methods: The two studies included 2396 and 2033 subjects, respectively. The International Diabetes Federation (IDF) diagnostic criteria were applied, and the data were weighed for type of settlement and age. Read More

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http://dx.doi.org/10.4137/CMED.S24742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431479PMC
May 2015
6 Reads

Predictors of abnormal bone mass density in adult patients with homozygous sickle-cell disease.

Clin Med Insights Endocrinol Diabetes 2015 7;8:35-40. Epub 2015 May 7.

Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain. ; College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Background: Adult patients with sickle-cell disease (SCD) often have multiple bone compactions causing tissue hypoxia and osteonecrosis. The impact on bone abnormalities lesion detected by bone mass density is not well defined.

Aim: The study is a cross sectional, perspective was designed to assess the prevalence of abnormal BMD in adult Bahraini patients with SCD and to assess the predictive risk of different metabolic variables such as serum level of vitamin D3, testosterone, and parathyroid hormone in addition to lactate dehydrogenase (LDH), hemoglobin (Hb), and reticulocyte count for the development of abnormal bone density on dual X-ray absorptiometry (DXA) scan. Read More

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http://dx.doi.org/10.4137/CMED.S24501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426937PMC
May 2015
28 Reads

The Relationship between Thyroid Function and Depressive Symptoms-the FIN-D2D Population-Based Study.

Clin Med Insights Endocrinol Diabetes 2015 20;8:29-33. Epub 2015 Apr 20.

Unit of Family Practice, Central Finland Central Hospital, Jyväskylä, Finland. ; Primary Health Care Unit, University of Eastern Finland, Kuopio, Finland.

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45-75 years old from Finland. Read More

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http://dx.doi.org/10.4137/CMED.S24111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406392PMC
May 2015
15 Reads

Immune checkpoint inhibitor therapy associated hypophysitis.

Clin Med Insights Endocrinol Diabetes 2015 25;8:21-8. Epub 2015 Mar 25.

Division of Endocrinology and Metabolism, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, Canada.

Ipilimumab is a monoclonal antibody directed against CTLA4 T-lymphocyte antigen used as cancer therapy. Immune-related adverse events are common side effects and may include hypophysitis-related hypopituitarism. The clinical features of six patients with ipilimumab-induced hypophysitis (IH) are described. Read More

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http://dx.doi.org/10.4137/CMED.S22469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376202PMC
April 2015
7 Reads

Health economic evaluation of type 2 diabetes mellitus: a clinical practice focused review.

Clin Med Insights Endocrinol Diabetes 2015 24;8:13-9. Epub 2015 Mar 24.

McGill Nutrition Centre, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

Type 2 diabetes mellitus (T2D) is a growing healthcare burden primarily due to long-term complications. Strict glycemic control helps in preventing complications, and early introduction of insulin may be more cost-effective than maintaining patients on multiple oral agents. This is an expert opinion review based on English peer-reviewed articles (2000-2012) to discuss the health economic consequences of T2D treatment intensification. Read More

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http://journals.sagepub.com/doi/10.4137/CMED.S20906
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http://dx.doi.org/10.4137/CMED.S20906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374638PMC
April 2015
17 Reads

Unhealthy weight control practices: culprits and clinical recommendations.

Clin Med Insights Endocrinol Diabetes 2015 17;8:7-11. Epub 2015 Feb 17.

Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

Preoccupation with weight status and a desire to lose weight appears common. Many individuals seek "magic bullet" approaches to weight loss and waive the risks of using these products. In this paper, we review the challenges of weight maintenance, highlight some unhealthy weight control practices, and discuss the futility and potential danger of unregulated weight control agents. Read More

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http://dx.doi.org/10.4137/CMED.S23060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334025PMC
March 2015
9 Reads

Combination of linagliptin and metformin for the treatment of patients with type 2 diabetes.

Authors:
Thomas Haak

Clin Med Insights Endocrinol Diabetes 2015 4;8:1-6. Epub 2015 Jan 4.

Diabetes Klinik Bad Mergentheim GmbH & Co. KG, Bad Mergentheim, Germany.

Type 2 diabetes mellitus (T2DM) is a progressive condition requiring long-term treatment. Most patients with T2DM are unable to maintain normoglycemia using metformin alone; thus, combination therapy is a pivotal part of disease management. Addition of the dipeptidyl peptidase-4 inhibitor linagliptin, with its proven efficacy, low propensity for hypoglycemia, and weight neutrality, has been shown to improve glycemic control for patients who are not well controlled with metformin. Read More

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http://dx.doi.org/10.4137/CMED.S10360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284079PMC
January 2015
7 Reads

Monitoring HIV-infected Patients with Diabetes: Hemoglobin A1c, Fructosamine, or Glucose?

Clin Med Insights Endocrinol Diabetes 2014 4;7:41-5. Epub 2014 Dec 4.

Division of Endocrinology and Friedman Diabetes Institute, Albert Einstein College of Medicine/Beth Israel Medical Center, New York, NY, USA.

Background: Published studies report inappropriately low hemoglobin A1C (HbA1c) values that underestimate glycemia in HIV patients.

Methods: We reviewed the charts of all HIV patients with diabetes mellitus (DM) at our clinic. Fifty-nine patients had HbA1c data, of whom 26 patients also had fructosamine data. Read More

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http://dx.doi.org/10.4137/CMED.S19202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259549PMC
December 2014
5 Reads

Plantar pressure as a risk assessment tool for diabetic foot ulceration in egyptian patients with diabetes.

Clin Med Insights Endocrinol Diabetes 2014 2;7:31-9. Epub 2014 Dec 2.

Department of Endocrinology & Metabolism, AL Azhar Faculty of Medicine for Girls, Cairo, Egypt.

Background: Diabetic foot ulceration is a preventable long-term complication of diabetes. In the present study, peak plantar pressures (PPP) and other characteristics were assessed in a group of 100 Egyptian patients with diabetes with or without neuropathy and foot ulcers. The aim was to study the relationship between plantar pressure (PP) and neuropathy with or without ulceration and trying to clarify the utility of pedobarography as an ulceration risk assessment tool in patients with diabetes. Read More

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http://journals.sagepub.com/doi/10.4137/CMED.S17088
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http://dx.doi.org/10.4137/CMED.S17088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257475PMC
December 2014
9 Reads

A clinical perspective of canagliflozin in the management of type 2 diabetes mellitus.

Clin Med Insights Endocrinol Diabetes 2014 17;7:25-30. Epub 2014 Sep 17.

Albany College of Pharmacy and Health Sciences-Vermont Campus, Colchester, VT.

Objective: To assess the real-world efficacy and safety of the first sodium-glucose cotransporter-2 inhibitor, canagliflozin, in the treatment of patients with type 2 diabetes mellitus (T2DM).

Methods: This observational study assessed the efficacy and tolerability of canagliflozin in T2DM patients. Primary study outcomes were changes in HbA1C and weight, and percentage of patients reporting adverse effects of therapy. Read More

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http://dx.doi.org/10.4137/CMED.S18182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179440PMC
October 2014
10 Reads