4,414,886 results match your criteria Clinical Medicine Insights: Ear Nose and Throat [Journal]


Eating behaviour and oxytocin in patients with childhood-onset craniopharyngioma and different grades of hypothalamic involvement.

Pediatr Obes 2019 Apr 23:e12527. Epub 2019 Apr 23.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.

Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.

Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC). Read More

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http://dx.doi.org/10.1111/ijpo.12527DOI Listing

The Association Between Telemedicine and Emergency Department (ED) Disposition: A Stepped Wedge Design of an ED-Based Telemedicine Program in Critical Access Hospitals.

J Rural Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Management and Policy, University of Iowa College of Public Health, Iowa City, Iowa.

Purpose: To study the relationship between the availability and activation of emergency department-based telemedicine (teleED) and patient disposition in Critical Access Hospitals (CAHs).

Methods: A non randomized stepped wedge design examined 133,396 ED visits in 15 CAHs that subscribe to a single teleED provider. Data were available for at least 12 months prior to teleED implementation and at least 12 months of post-implementation. Read More

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http://dx.doi.org/10.1111/jrh.12370DOI Listing

Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.

Addict Biol 2019 Apr 23:e12762. Epub 2019 Apr 23.

Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CUD. Their relationship to addiction endophenotypes such as cannabis-related state satiety, the salience of appetitive cues, and craving after acute cannabinoid administration has not been investigated. Read More

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http://dx.doi.org/10.1111/adb.12762DOI Listing
April 2019
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Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

Swimming Upstream: Disentangling the Association between Alcohol Intake and Venous Thromboembolism.

Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark.

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http://dx.doi.org/10.1055/s-0039-1687881DOI Listing

Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Objective:  To explore the clinical significance of early premature infant oral motor intervention (PIOMI) in the prognosis of premature infants.

Study Design:  Infants were randomly divided into an intervention group ( = 78) and a control group ( = 73). PIOMI was given to the intervention group 15 to 30 minutes before feeding once a day for 14 days. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685448
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http://dx.doi.org/10.1055/s-0039-1685448DOI Listing
April 2019
1 Read

The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma.

Eur J Pediatr Surg 2019 Apr 23. Epub 2019 Apr 23.

The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States.

Objective:  Vascular endothelial growth factor (VEGF) and its receptor act as a major contributor to lymphangioma, but their role on nonrecurrent and recurrent lymphangiomas remain unclear. We aim to investigate those factors in the generation of recurrent lymphangioma.

Materials And Methods:  Patients diagnosed with lymphangioma from January 2005 to December 2012 in our hospital were collected and divided into nonrecurrent and recurrent lymphangiomas. Read More

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http://dx.doi.org/10.1055/s-0039-1687869DOI Listing

[Surgical removal of a follicular carcinoma of the thyroid gland in a snakehead (Channa barca, HAMILTON, 1822)].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):125-132. Epub 2019 Apr 23.

Klinik für Vögel, Reptilien, Amphibien und Fische, Justus-Liebig-Universität Gießen.

Inflammatory processes, neoplastic growths or rare dysontogenetic malformations may cause mass formation in the gills of fish. In the present case, a follicular carcinoma of the thyroid gland in a Barca snakehead and its surgical removal are reported, and neoplasms in fish are discussed. Following clinical, radiological, cytological and sonographic examinations, the gill-associated partly cystic mass was incompletely removed surgically. Read More

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http://dx.doi.org/10.1055/a-0858-9573DOI Listing

[Treatment of acute viral feline upper respiratory tract infections].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):98-109. Epub 2019 Apr 23.

Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München.

The main causative agents of feline upper respiratory tract disease (FURTD) are feline herpesvirus-1 (FHV-1) and feline calicivirus (FCV). These viral infections are common, especially in multiple cat households. Severely affected cats often need to be hospitalized. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0870-0801
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http://dx.doi.org/10.1055/a-0870-0801DOI Listing
April 2019
1 Read

[Nasal discharge in dogs - are microbiological and histopathological examinations clinically useful?]

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):84-96. Epub 2019 Apr 23.

Klinik für Kleintiere, HNO-Abteilung, Universitätstierklinikum Leipzig.

Objective: Retrospective evaluation of the diagnostic value of bacterial culture of nasal mucosal swabs and histopathologic assessment of nasal mucosal biopsies in dogs with nasal discharge.

Material And Methods: Medical records of dogs with the predominant clinical sign of nasal discharge that were referred to the ENT Unit of the Small Animal Department between January 2015 and December 2016 were reviewed.

Results: Data of 85 dogs were evaluated. Read More

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http://dx.doi.org/10.1055/a-0863-6667DOI Listing

[Management of urethral stones in dogs using pneumatic and laser lithotripsy].

Authors:
Peter Pantke

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):77-83. Epub 2019 Apr 23.

AniCura Tierärztliche Klinik Bielefeld.

Objective: Description of clinical experience with two different lithotripsy modalities for treatment of urethral stones in dogs.

Material And Methods: Retrospective analysis (October 2016 - November 2017) of medical records from dogs with urinary stones that underwent transurethral pneumatic or laser lithotripsy.

Results: In 28 male and 5 female dogs, either pneumatic lithotripsy (39 %) or laser lithotripsy (61 %) was performed. Read More

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http://dx.doi.org/10.1055/a-0858-9613DOI Listing

An Unusual Presentation of Cytomegalovirus Infection: Generalized Edema.

Med Princ Pract 2019 Apr 24. Epub 2019 Apr 24.

Objective: Cytomegalovirus (CMV) infection may rarely lead to protein-losing gastropathy that presented with nausea, vomiting, abdominal pain, edema in immunocompetent children, but extremely rarely with only generalized edema.

Clinical Presentation And Intervention: A previously healthy 5-year-old boy presented with generalized edema without any other symptoms. He had hypoalbuminemia but no proteinuria. Read More

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http://dx.doi.org/10.1159/000500511DOI Listing

Long-Term Outcome of Patients Operated with Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment.

Ophthalmic Res 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Purpose: To determine the long-term outcome of patients operated with pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) and to identify potential predictors for poor visual outcome.

Methods: Prospective, observational 30-month study of patients operated for primary RRD with PPV. Examinations were performed preoperatively and after months 2, 6, and 30. Read More

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http://dx.doi.org/10.1159/000499130DOI Listing

The Association between Chronicity of Migraine and Complementary and Alternative Medication Use: The Turkish Perspective.

Eur Neurol 2019 Apr 23;81(1-2):24-29. Epub 2019 Apr 23.

Department of Neurology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey,

Background And Purpose: The term of Complementary and Alternative Medication (CAM) is described by patients as all types of practices to prevent or treat illnesses, which are not currently considered as a part of conventional medicine. Although the advance in treatment for migraine, some patients prefer CAM therapies due to their concerns about conventional therapies. The aim of this study was to evaluate the association between CAM use and chronicity of migraine among Turkish migraineurs. Read More

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https://www.karger.com/Article/FullText/499910
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http://dx.doi.org/10.1159/000499910DOI Listing
April 2019
4 Reads

Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease.

Eur Neurol 2019 Apr 23;81(1-2):13-18. Epub 2019 Apr 23.

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan,

Background: Caudate nucleus atrophy is a well-known neuroimaging feature of Huntington's disease (HD). Some researchers have reported a decrease in the volume of the striatum on magnetic resonance images (MRIs) even in the presymptomatic stage of the disease. Despite the many neuroimaging studies on HD, the optimal method for measuring the caudate nucleus area on MRIs and the most effective cutoff values for diagnosing HD remain unclear. Read More

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http://dx.doi.org/10.1159/000499909DOI Listing

Effects of Botulinum Toxin A on Allodynia in Chronic Migraine: An Observational Open-Label Two-Year Study.

Eur Neurol 2019 Apr 23;81(1-2):37-46. Epub 2019 Apr 23.

Applied Neurophysiology and Pain, ANP- Unit, Bari Aldo Moro University, Bari, Italy.

Background: Onabotulinumtoxin A (OBT-A) is a treatment option for chronic migraine (CM), though the possible effect on central sensitization and allodynia is still unknown.

Aims: The present study aimed to evaluate (1) the long-term outcome of allodynia in a group of CM treated with OBT-A (2) if the presence and severity of allodynia could predict the long-term effect of OBT-A (3) if the improvement of allodynia, could contribute to the clinical efficacy of OBT-A.

Methods: This was an observational, open-label, cohort study conducted on 99 CM patients treated for 1 year and 44 patients treated for 2 years with periodic OBT-A 155-195 U injections. Read More

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http://dx.doi.org/10.1159/000499764DOI Listing

Microbleeds of Lacunar Infarction and Middle Cerebral Artery Flow Velocity of Branch Atheromatous Disease Are Essential Factors of Stroke Etiology.

Eur Neurol 2019 Apr 23;81(1-2):19-23. Epub 2019 Apr 23.

Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.

Background: Although subcortical infarction patients sometimes show larger infarction size than the definition of small vessel occlusion (SVO), there are no specific predictors of larger size. The aim of this study was to identify the factors, including magnetic resonance imaging (MRI) and ultrasonographic parameters, to predict larger subcortical infarction.

Methods: Consecutive patients with acute supratentorial subcortical infarction were studied. Read More

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http://dx.doi.org/10.1159/000494672DOI Listing

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review.

Digestion 2019 Apr 23:1-17. Epub 2019 Apr 23.

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Oral 5-aminosalicylic acid (5-ASA, mesalazine) is the first choice therapeutic agent for treating mild-to-moderate ulcerative colitis (UC). Unfortunately a significant group of patients fail to respond. Therapeutic drug monitoring might help to maintain or induce remission by providing a tool for optimization of 5-ASA therapy. Read More

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https://www.karger.com/Article/FullText/499331
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http://dx.doi.org/10.1159/000499331DOI Listing
April 2019
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Consumption of Sugar-Sweetened Beverages in Paediatric Age: A Position Paper of the European Academy of Paediatrics and the European Childhood Obesity Group.

Ann Nutr Metab 2019 Apr 23;74(4):296-302. Epub 2019 Apr 23.

Medical Faculty, University of Rzeszów, Rzeszów, Poland.

Background: Health risks associated with the high consumption of sugar-sweetened beverages (SSBs) include overweight or obesity and their complications such as diabetes, as well as oral and dental decay, among others.

Aim: The aim of the present statement is to inform health care professionals, parents, care-givers, teachers and school head teachers, stakeholders and governing bodies about the risks associated with drinking SSBs in infants, children and adolescents.

Methods: We searched PubMed and the Cochrane databases for English language studies published from 2010 through October 1, 2018, for randomized clinical trials, meta-analyses, systematic reviews and observational studies (search terms are reported in eAppendix in the Supplement). Read More

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http://dx.doi.org/10.1159/000499828DOI Listing

The Controlling Nutritional Status Score and Postoperative Complication Risk in Gastrointestinal and Hepatopancreatobiliary Surgical Oncology: A Systematic Review and Meta-Analysis.

Ann Nutr Metab 2019 Apr 23;74(4):303-312. Epub 2019 Apr 23.

Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

The controlling nutritional status (CONUT) score is associated with prognosis in gastrointestinal (GI) cancer patients, but the clinical significance of the CONUT score for postoperative short-term outcome remains controversial. The aim of this study was to investigate the impact of the CONUT score on postoperative outcomes in patients with GI and hepatopancreatobiliary (HPB) cancers. We conducted a systematic literature search of Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. Read More

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http://dx.doi.org/10.1159/000500233DOI Listing

Chronic recording and electrochemical performance of amorphous silicon carbide-coated Utah electrode arrays implanted in rat motor cortex.

J Neural Eng 2019 Apr 23. Epub 2019 Apr 23.

Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas, UNITED STATES.

Clinical applications of implantable microelectrode arrays are currently limited by device failure due to, in part, mechanical and electrochemical failure modes. To overcome this challenge, there is significant research interest in the exploration of novel array architectures and encapsulation materials. Amorphous silicon carbide (a-SiC) is biocompatible and corrosion resistant, and has recently been employed as a coating on biomedical devices including planar microelectrode arrays. Read More

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http://dx.doi.org/10.1088/1741-2552/ab1bc8DOI Listing

Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Chapman, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom of Great Britain and Northern Ireland.

Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid concentrations are extremely low before E14.5, glucocorticoid receptor (GR) is expressed in the heart from E10. Read More

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http://dx.doi.org/10.1530/JOE-18-0666DOI Listing

Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

J Endocrinol 2019 Jul;242(1):T51-T68

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk - effects that span multiple generations. This relationship begins early, in the periconceptional period and extends into embryonic, fetal and early infant phases of life. Now known as the Developmental Origins of Health and Disease (DOHaD), this concept describes the adaptations that a developing organism makes in response to early life cues, resulting in adjustments in homeostatic systems that may prove maladaptive in postnatal life, leading to an increased risk of chronic disease and/or the inheritance of risk factors across generations. Read More

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https://joe.bioscientifica.com/view/journals/joe/242/1/JOE-1
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http://dx.doi.org/10.1530/JOE-19-0048DOI Listing
July 2019
1 Read

Myelopathy after zoster virus infection in immunocompetent patients: A case series.

J Spinal Cord Med 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Habib Bourguiba University Hospital , Sfax , Tunisia.

Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607053DOI Listing

Impactibility Model for Population Health Management in High-Cost Elderly Heart Failure Patients: A Capture Method Using the ACG System.

Popul Health Manag 2019 Apr 23. Epub 2019 Apr 23.

6 College of Public Health, University of Georgia, Athens, Georgia.

The aim of the present study is to use the ACG (Adjusted Clinical Groups) System to create an impactibility model by identifying homogeneous clinical subgroups of patients with high risk of an adverse health outcome in a population of heart failure patients with complex health care needs (PCHCN). This method will allow policy makers to target and prioritize services for the highest risk PCHCN in the context of limited health care resources, by identifying relatively homogeneous groups of patients with similar comorbidities. Subjects classified in 2012 as PCHCN in a local health unit by the ACG System were linked with hospital discharge records in 2013. Read More

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http://dx.doi.org/10.1089/pop.2018.0190DOI Listing

Effectiveness of Telephone-Administered Cognitive-Behavioral Psychotherapy for Depression With Versus Without Additional Letters: A Randomized Controlled Trial.

Telemed J E Health 2019 Apr 23. Epub 2019 Apr 23.

3 Clinical Psychology and Psychotherapy Research, Institute of Psychology, University of Zurich, Zurich, Switzerland.

p d. Read More

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http://dx.doi.org/10.1089/tmj.2018.0311DOI Listing

Patient-Reported Experiences in Discussing Prescribed Medications with a Health Care Provider: Evidence for Racial/Ethnic Disparities in a Large Health Care Delivery System.

Popul Health Manag 2019 Apr 23. Epub 2019 Apr 23.

1 Palo Alto Medical Foundation Research Institute, Sutter Health, Palo Alto, California.

The objective was to understand patient-reported experiences in communicating with a health care provider about prescribed medications in a health care setting serving diverse racial/ethnic groups. Adult patients who completed a patient-experience survey and received a prescription for a hypertension, hyperlipidemia, or diabetes medication at the surveyed encounter were studied (N = 19,006). Data were collected in a large mixed-payer outpatient health care system in northern California between 2011 and 2014. Read More

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https://www.liebertpub.com/doi/10.1089/pop.2018.0206
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http://dx.doi.org/10.1089/pop.2018.0206DOI Listing
April 2019
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Anticholinergic Burden and Dry Mouth in Middle-Aged People.

JDR Clin Trans Res 2019 Apr 23:2380084419844511. Epub 2019 Apr 23.

1 Periodontology and Geriatric Dentistry, Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland.

Introduction: Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.

Objectives: The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people. Read More

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http://dx.doi.org/10.1177/2380084419844511DOI Listing

Billed and Paid Amounts for Preventive Procedures in Dental Medicaid.

JDR Clin Trans Res 2019 Apr 23:2380084419842533. Epub 2019 Apr 23.

4 Department of Clinical Services, School of Dentistry, Marquette University, Milwaukee, WI, USA.

Objective: To examine trends and variations in billed and paid amounts for preventive dental procedures by race/ethnicity, age, and sex in Wisconsin dental Medicaid.

Methods: We analyzed data from the 2001 to 2013 Wisconsin Medicaid claims database for preventive dental procedures for children and adults. Billed and paid amounts for preventive dental procedures were aggregated over a visit and adjusted for inflation based on the Medical Care Consumer Price Index produced by the Bureau of Labor Statistics for 2013. Read More

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http://journals.sagepub.com/doi/10.1177/2380084419842533
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http://dx.doi.org/10.1177/2380084419842533DOI Listing
April 2019
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Dissociable effects of cannabis with and without cannabidiol on the human brain's resting-state functional connectivity.

J Psychopharmacol 2019 Apr 23:269881119841568. Epub 2019 Apr 23.

2 Clinical Psychopharmacology Unit, University College London, London, UK.

Background: Two major constituents of cannabis are Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.

Aims: We examined the effects of two strains of cannabis and placebo on the human brain's resting-state networks using fMRI. Read More

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http://dx.doi.org/10.1177/0269881119841568DOI Listing

Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation.

JDR Clin Trans Res 2019 Apr 23:2380084419844937. Epub 2019 Apr 23.

1 Section of Periodontology and Dental Prevention, Division of Oral Diseases of Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathway is stimulated by bacteria and, together with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), propagates proinflammatory responses.

Objectives: We aimed to evaluate the TREM-1/PGLYRP1/interleukin (IL)-1β regulation in response to biofilm accumulation and removal in an experimental human gingivitis model.

Methods: The study (n = 42 participants, mean age: 23. Read More

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http://journals.sagepub.com/doi/10.1177/2380084419844937
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http://dx.doi.org/10.1177/2380084419844937DOI Listing
April 2019
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Letters From Our Readers.

Authors:
Wentian Sun Jun Liu

Angle Orthod 2019 May;89(3):522

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. (e-mail: ).

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http://dx.doi.org/10.2319/0003-3219-89.3.522DOI Listing

Letters From Our Readers.

Angle Orthod 2019 May;89(3):523

Senior Clinical Lecturer, Orthodontic Department, Hebrew University, Jerusalem, and Clinical Instructor, Tel- Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.2319/0003-3219-89.3.523DOI Listing

Intronic Polymorphisms in Gene of Second Heart Field as Risk Factors for Human Congenital Heart Disease in a Chinese Population.

DNA Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

1 Center for Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Transcriptional factors and signaling factors in the second heart field (SHF) contribute to cardiac development. However, the associations of intronic gene variants in the SHF with congenital heart disease (CHD) remain ununderstood. Ten single nucleotide polymorphisms (SNPs) from our previous sequencing data were selected and then genotyped in 383 CHD patients and 384 healthy controls in a Chinese population. Read More

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http://dx.doi.org/10.1089/dna.2018.4254DOI Listing

Resolvin D2 elevates cAMP to increase intracellular [Ca] and stimulate secretion from conjunctival goblet cells.

FASEB J 2019 Apr 23:fj201802467R. Epub 2019 Apr 23.

Schepens Eye Research Institute, Massachusetts Eye and Ear-Harvard Medical School, Boston, Massachusetts, USA.

Under physiologic conditions, conjunctival goblet cells (CGCs) secrete mucins into the tear film to preserve ocular surface homeostasis. Specialized proresolving mediators (SPMs), like resolvins (Rvs), regulate secretion from CGCs and actively terminate inflammation. The purpose of this study was to determine if RvD2 stimulated mucin secretion and to investigate the cellular signaling components. Read More

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http://dx.doi.org/10.1096/fj.201802467RDOI Listing

Long non-coding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial-mesenchymal transition in pancreatic cancer.

Biochem Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases , No.295, Xichang Road , Kunming , China , 650032 ;

Background: This study focuses on lncRNA XIST, a lncRNA involved in multiple human cancers, and aims to investigate the functional significance of XIST and the molecular mechanism underlying the EMT in PC.

Methods: Clinical specimens from 25 patients and five human bladder cancer cell lines were analyzed for XIST, YAP and microRNA(miR)-34a by qRT-PCR and Immunohistochemistry (IHC). To investigate how XIST influences the cell proliferation, invasion, apoptosis in PC, we performed the CCK-8 assay, transwell assay and flow cytometry. Read More

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http://dx.doi.org/10.1139/bcb-2018-0274DOI Listing

Quality of Lactation Studies Investigating Antidepressants.

Breastfeed Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Pharmacy, Isala, Zwolle, the Netherlands.

The aim of this study was to determine the quality of lactation studies investigating antidepressants in breast milk according to the Food and Drug Administration (FDA) draft guidelines and the article of Begg, published in the official journal of the International Lactation Consultant Association (ILCA). We used PubMed and LactMed for the literature search. Furthermore, cross references were searched for additional studies. Read More

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http://dx.doi.org/10.1089/bfm.2019.0021DOI Listing

Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently RIP1 kinase inhibitors have advanced into early clinical trials for evaluation in inflammatory diseases such as psoriasis, rheumatoid arthritis and ulcerative colitis, and neuro-logical diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. In this paper we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00318DOI Listing

[MASK (Mobile Airways Sentinel Network). ARIA's comprehensive solution for mobile app for the multimorbidity of allergic rhinitis and asthma].

Rev Alerg Mex 2019 Jan-Mar;66(1):140-146

Médica Sur, Centro de Excelencia en Asma y alergia, Ciudad de México, México.

The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate. MASK (Mobile Airways Sentinel Network) is an integral part of a project that is supported by the European Union against chronic diseases and focused on active and healthy aging. MASK represents the third phase of ARIA (Allergic Rhinitis and its Impact on Asthma), in which, by using a mobile application in a smart device, the objective is to guide the patient in the control of his/her multi-morbidity, AR and/or allergic conjunctivitis (AC) and/or asthma. Read More

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http://dx.doi.org/10.29262/ram.v66i1.578DOI Listing

[Pericarditis and pericardial effusion as the first presentation of systemic lupus erythematosus. Case report].

Rev Alerg Mex 2019 Jan-Mar;66(1):132-139

Hospital Pediátrico de Sinaloa, Departamento de Pediatría Médica, Culiacán, Sinaloa, México.

Background: Acute pericarditis is rare in children; it can evolve to effusion or even cardiac tamponade. The main infectious agents are viruses and bacteria. The pharmacological treatment includes NSAIDs; just a few patients need pericardiocentesis. Read More

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http://dx.doi.org/10.29262/ram.v66i1.528DOI Listing

[Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis].

Rev Alerg Mex 2019 Jan-Mar;66(1):128-131

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Antioquia, Colombia.

Background: Inflammation caused by chronic diseases and the constant use of systemic corticosteroids could be linked to the increased incidence of venous thromboembolic disease.

Clinical Case: A 47 year-old man with severe asthma of difficult control and allergic bronchopulmonary aspergillosis who, although the treatment was optimal, continued to have recurrent exacerbations and the need for systemic corticosteroids. He had edema in his left leg. Read More

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http://dx.doi.org/10.29262/ram.v66i1.352DOI Listing

[Anaphylaxis in a lactating infant who is allergic to cow's milk protein].

Rev Alerg Mex 2019 Jan-Mar;66(1):123-127

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Antioquia, Colombia.

Background: Allergy to cow's milk protein is a common problem in children. The clinical manifestations of the reactions that are mediated by IgE are varied and the anaphylactic reactions can be life-threatening.

Clinical Case: A girl at an age of four months and a half that, five minutes after consuming cereal with cow's milk, had rashes in the perioral area and extensive pruritic micropapular lesions associated with vomit and inspiratory stridor. Read More

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http://dx.doi.org/10.29262/ram.v66i1.350DOI Listing
April 2019
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Adverse immune reactions and non-immune medications for perioperative use.

Rev Alerg Mex 2019 Jan-Mar;66(1):99-114

Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México.

Reactions to medications can occur through a mechanism mediated by immunoglobulin or otherwise, not both. Drug allergy is a type of adverse reaction to the drug and comprises a range of hypersensitivity reactions mediated by different immunological mechanisms with diverse clinical manifestations. A rate of 3. Read More

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http://dx.doi.org/10.29262/ram.v66i1.541DOI Listing

[Dialyzed leukocyte extracts for the treatment of recurrent and severe infections in pediatric patients with cellular immunodeficiency: 15 years of experience].

Rev Alerg Mex 2019 Jan-Mar;66(1):27-37

Instituto Mexicano del Seguro Social, Hospital de Especialidades 25, Unidad Médica de Alta Especialidad, Nuevo León, México.

Background: Dialyzable leukocyte extracts (DLE) have been used to treat several cellular immunodeficiency.

Objective: To review the experience of a tertiary hospital in the use of DLE for the treatment of recurrent or severe infections in children with acquired cellular immunodeficiency not due to HIV.

Methods: We reviewed the medical records of all children who received treatment with EDL of human or bovine origin between 1986 and 2000 to detect recurrent or severe infections without response to a specific antimicrobial therapy and with a quantitative or qualitative deficit in the cellular immune response. Read More

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http://dx.doi.org/10.29262/ram.v66i1.531DOI Listing

[Evaluation of diagnostic and management concepts of anaphylaxis in non-allergist physicians in Colombia].

Rev Alerg Mex 2019 Jan-Mar;66(1):18-26

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Background: Several reports show deficiencies in the knowledge of physicians about the diagnostic criteria and the treatment of anaphylaxis, a condition that can have fatal consequences.

Objective: To evaluate the knowledge of physicians in Colombia on the fundamental aspects of anaphylaxis in diagnosis and treatment.

Methods: Analytical cross-sectional study, carried out through a survey of 11 questions that evaluate clinical aspects of anaphylaxis, addressed to general practitioners and specialists in different health areas resident in Colombia. Read More

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http://dx.doi.org/10.29262/ram.v66i1.524DOI Listing

[Allergy to food in adults with allergic respiratory diseases: prevalence and clinical manifestations].

Rev Alerg Mex 2019 Jan-Mar;66(1):1-8

Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, México.

Background: Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.

Objective: To determine the prevalence of food allergy in patients with allergic rhinitis and asthma; as well as the foods and symptoms most related to said problem.

Methods: Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. Read More

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http://dx.doi.org/10.29262/ram.v66i1.400DOI Listing

Clinical features and prognosis of microscopic polyangiitis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

Clin Respir J 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory and Critical Care Medicine, Beijing, Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, Chao-Yang Hospital-Beijing Institute of Respiratory Medicine, Capital Medical University, No. 8 Gongren Tiyuchang South Road, Beijing, 100020, P.R. China.

Introduction: Pulmonary involvement in microscopic polyangiitis (MPA) is common, little is known about the clinical features of MPA with interstitial pneumonia (MPA-IP).

Objectives: This study aimed to explore the prevalence of microscopic polyangiitis associated usual interstitial pneumonia (UIP)(MPA-UIP) and compare its clinical features and prognosis with those of MPA-non-UIP and idiopathic pulmonary fibrosis (IPF).

Methods: A total of 73 patients with MPA-IP were identified and divided into MPA-UIP patients and MPA-non-UIP patients. Read More

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http://dx.doi.org/10.1111/crj.13032DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing
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