303 results match your criteria Clinical Medicine Insights: Cardiology [Journal]


Physical Exercise for Individuals with Hypertension: It Is Time to Emphasize its Benefits on the Brain and Cognition.

Clin Med Insights Cardiol 2019 31;13:1179546819839411. Epub 2019 Mar 31.

NEUROEX-Research Group in Physical Activity, Cognition and Behavior, Health Science Center, Federal University of Rio Grande do Norte, Natal/RN, Brazil.

Hypertension affects more than 40% of adults worldwide and is associated with stroke, myocardial infarction, heart failure, and other cardiovascular diseases. It has also been shown to cause severe functional and structural damage to the brain, leading to cognitive impairment and dementia. Furthermore, it is believed that these cognitive impairments affect the mental ability to maintain productivity at work, ultimately causing social and economic problems. Read More

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http://dx.doi.org/10.1177/1179546819839411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444761PMC

Impact of Cine Frame Selection on Quantitative Coronary Angiography Results.

Clin Med Insights Cardiol 2019 31;13:1179546819838232. Epub 2019 Mar 31.

Japan Cardiovascular Imaging Core Laboratory, Tokyo, Japan.

We evaluated intra- and interobserver variability of quantitative coronary angiography (QCA) due to cine frame selection for 9 coronary stenoses. The projection was selected in advance. Cine frames were selected by 2 blinded experts (blind frame QCA) followed by assignment by supervisor (pre-selected frame QCA). Read More

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http://dx.doi.org/10.1177/1179546819838232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444776PMC

Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial.

Can J Cardiol 2019 Apr 31;35(4):430-437. Epub 2018 Dec 31.

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: The effect of sex on self-reported frailty in acute coronary syndromes (ACS) is unclear. We examined the prevalence of self-reported frailty and its association with all-cause death among men and women.

Methods: Elderly (≥ 65 years) male (n = 2691) and female (n = 2305) patients with ACS enrolled in the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial were screened using the Fried Frailty Index. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183141
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http://dx.doi.org/10.1016/j.cjca.2018.12.035DOI Listing
April 2019
3 Reads

Contrast Enhancement and Image Quality Influence Two- and Three-dimensional Echocardiographic Determination of Left Ventricular Volumes: Comparison With Magnetic Resonance Imaging.

Clin Med Insights Cardiol 2019 5;13:1179546819831980. Epub 2019 Mar 5.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Purpose: To evaluate the effect of image quality and contrast enhancement (CE) on left ventricular (LV) volume determination by two- (2D) and three-dimensional (3D) echocardiography (2DE/3DE).

Methods: We studied 32 post-myocardial infarction (MI) patients without (2DE/3DE) and with CE (CE2DE/CE3DE), in comparison with cardiac magnetic resonance imaging (CMR).

Results: Two-dimensional echocardiography showed the largest negative bias versus CMR for diastolic and systolic volumes (-59, -28 mL, respectively) with lower biases for CE2DE (-37, -22 mL), 3DE (-31, -17 mL), and CE3DE (-17, -11 mL). Read More

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http://dx.doi.org/10.1177/1179546819831980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402058PMC
March 2019
1 Read

Center Variation in Medicare Spending for Durable Left Ventricular Assist Device Implant Hospitalizations.

JAMA Cardiol 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiac Surgery, University of Michigan Medical School, Ann Arbor.

Importance: Hospitalizations for durable left ventricular assist device (LVAD) implants are expensive and increasingly common. Insights into center-level variation in Medicare spending for these hospitalizations are needed to inform value improvement efforts.

Objective: To examine center-level variation in Medicare spending for durable LVAD implant hospitalizations and its association with clinical outcomes. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439617PMC
January 2019
1 Read

Fusidic Acid: A Neglected Risk Factor for Statin-Associated Myopathy.

Clin Med Insights Cardiol 2018 4;12:1179546818815162. Epub 2018 Dec 4.

Uppsala University Hospital and Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Background: Statins are widely used lipid-lowering drugs used for the prevention of cardiovascular disease. Statins are known to cause myopathy, an adverse drug reaction with various clinical features rhabdomyolysis.

Objective: To describe clinical characteristics of statin-treated individuals who experienced myopathy and identify risk factors of statin-associated myopathy. Read More

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http://dx.doi.org/10.1177/1179546818815162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299330PMC
December 2018
1 Read

Moving From Heart Failure Guidelines to Clinical Practice: Gaps Contributing to Readmissions in Patients With Multiple Comorbidities and Older Age.

Clin Med Insights Cardiol 2018 4;12:1179546818809358. Epub 2018 Dec 4.

Cardiovascular Research, The University of Melbourne, Melbourne, VIC, Australia.

This feature article for the thematic series on congestive heart failure (CHF) readmissions aims to outline important gaps in guidelines for patients with multiple comorbidities and the elderly. Congestive heart failure diagnosis manifests as a 3-phase journey between the hospital and community, during acute, chronic stable, and end-of-life (palliative) phases. This journey requires in variable intensities a combination of multidisciplinary care within tertiary hospital or ambulatory care from hospital outpatients or primary health services, within the general community. Read More

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http://dx.doi.org/10.1177/1179546818809358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299336PMC
December 2018
9 Reads

Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

JAMA Cardiol 2019 Jan;4(1):7-15

Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI).

Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia.

Design, Setting, And Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439683PMC
January 2019
1 Read

Nanoimmunotherapy to treat ischaemic heart disease.

Nat Rev Cardiol 2019 Jan;16(1):21-32

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Atherosclerosis is a chronic disease of the large arteries and the underlying cause of myocardial infarction and stroke. Atherosclerosis is driven by cholesterol accumulation and subsequent inflammation in the vessel wall. Despite the clinical successes of lipid-lowering treatments, atherosclerosis remains one of the major threats to human health worldwide. Read More

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http://dx.doi.org/10.1038/s41569-018-0073-1DOI Listing
January 2019
4 Reads

Efficacy and Safety of Valsartan or Chlorthalidone vs. Combined Valsartan and Chlorthalidone in Patients With Mild to Moderate Hypertension: The VACLOR Study.

Clin Med Insights Cardiol 2018 3;12:1179546818796482. Epub 2018 Sep 3.

School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

Objective: To evaluate the efficacy and safety of valsartan (V) or chlorthalidone (C) monotherapy in comparison with a fixed combination of valsartan and chlorthalidone (V + C).

Methods: This 12-week multicenter randomized three-arm open-label study randomly allocated 72 patients to V or C as monotherapy or a combination of V + C. The aim was to measure changes in office systolic blood pressure (SBP) and diastolic blood pressure (DBP) and in 24-hour ambulatory blood pressure monitoring (ABPM) from baseline to week 12, in addition to medication tolerability. Read More

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http://dx.doi.org/10.1177/1179546818796482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122245PMC
September 2018
1 Read

The interstitium in cardiac repair: role of the immune-stromal cell interplay.

Nat Rev Cardiol 2018 Oct;15(10):601-616

The Jackson Laboratory, Bar Harbor, ME, USA.

Cardiac regeneration, that is, restoration of the original structure and function in a damaged heart, differs from tissue repair, in which collagen deposition and scar formation often lead to functional impairment. In both scenarios, the early-onset inflammatory response is essential to clear damaged cardiac cells and initiate organ repair, but the quality and extent of the immune response vary. Immune cells embedded in the damaged heart tissue sense and modulate inflammation through a dynamic interplay with stromal cells in the cardiac interstitium, which either leads to recapitulation of cardiac morphology by rebuilding functional scaffolds to support muscle regrowth in regenerative organisms or fails to resolve the inflammatory response and produces fibrotic scar tissue in adult mammals. Read More

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http://dx.doi.org/10.1038/s41569-018-0077-xDOI Listing
October 2018
23 Reads

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration.

Nat Rev Cardiol 2018 Nov;15(11):672-684

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.

The Hippo-YAP (Yes-associated protein) pathway is an evolutionarily and functionally conserved regulator of organ size and growth with crucial roles in cell proliferation, apoptosis, and differentiation. This pathway has great potential for therapeutic manipulation in different disease states and to promote organ regeneration. In this Review, we summarize findings from the past decade revealing the function and regulation of the Hippo-YAP pathway in cardiac development, growth, homeostasis, disease, and regeneration. Read More

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http://dx.doi.org/10.1038/s41569-018-0063-3DOI Listing
November 2018
18 Reads

Characterization of Low-Voltage Areas in Patients With Atrial Fibrillation: Insights From High-Density Intracardiac Mapping.

Can J Cardiol 2018 Aug 12;34(8):1033-1040. Epub 2018 Apr 12.

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Background: There is limited data on the scar burden in patients with atrial fibrillation (AF). In this study, we sought to evaluate the presence and extent of an abnormal left atrial (LA) substrate in patients with paroxysmal or persistent AF.

Methods: Consecutive patients who underwent initial AF catheter ablation were prospectively enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183029
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http://dx.doi.org/10.1016/j.cjca.2018.04.008DOI Listing
August 2018
20 Reads

The Significance of Thallium-201-Chloride SPECT Myocardial Perfusion Imaging in the Management of Patients With Stable Chronic Coronary Artery Disease.

Clin Med Insights Cardiol 2018 23;12:1179546818790562. Epub 2018 Jul 23.

Baptist Health South Florida, Coral Gables, FL, USA.

Background: Patients with stable coronary artery disease (CAD) can be evaluated for myocardial viability by examining reverse redistribution of Thallium-201 (TI) through cardiac scintigraphy. There is limited knowledge about association of a reverse redistribution with favorable cardiac outcomes. In this study, we hypothesized that higher left ventricular ejection fraction (LVEF), lower myocardial necrosis, fewer ischemic events, and less angina will be associated with reverse redistribution of TI imaging. Read More

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http://dx.doi.org/10.1177/1179546818790562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056776PMC
July 2018
15 Reads

: Type 2 Diabetes and Readmission for Heart Failure.

Authors:
Merlin C Thomas

Clin Med Insights Cardiol 2018 5;12:1179546818779588. Epub 2018 Jun 5.

Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Heart failure is a leading cause for hospitalisation and for readmission, especially in patients over the age of 65. Diabetes is an increasingly common companion to heart failure. The presence of diabetes and its associated comorbidity increases the risk of adverse outcomes and premature mortality in patients with heart failure. Read More

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http://dx.doi.org/10.1177/1179546818779588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992798PMC
June 2018
55 Reads

Effect of Xanthine Oxidase Inhibition on Arterial Stiffness in Patients With Chronic Heart Failure.

Clin Med Insights Cardiol 2018 5;12:1179546818779584. Epub 2018 Jun 5.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.

Background: The xanthine oxidase inhibitor allopurinol improves endothelial function in different populations, including patients with chronic heart failure (CHF). Its effect on arterial stiffness parameters is less clear. We investigated the effect of short-term low-dose allopurinol therapy on arterial stiffness in Saudi patients with stable mild-moderate CHF. Read More

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http://dx.doi.org/10.1177/1179546818779584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992797PMC
June 2018
3 Reads

Association of Patient Perceptions of Cardiovascular Risk and Beliefs on Statin Drugs With Racial Differences in Statin Use: Insights From the Patient and Provider Assessment of Lipid Management Registry.

JAMA Cardiol 2018 Aug;3(8):739-748

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.

Importance: African American individuals face higher atherosclerotic cardiovascular disease risk than white individuals; reasons for these differences, including potential differences in patient beliefs regarding preventive care, remain unknown.

Objective: To evaluate differences in statin use between white and African American patients and identify the potential causes for any observed differences.

Design, Setting, And Participants: Using the 2015 Patient and Provider Assessment of Lipid Management (PALM) Registry data, we compared statin use and dosing between African American and white outpatient adults who were potentially eligible for primary or secondary prevention statins. Read More

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2018.1511DOI Listing
August 2018
36 Reads

Comparison of Low-Density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation: Insights From the FOURIER Trial.

JAMA Cardiol 2018 Aug;3(8):749-753

Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which could result in undertreatment of high-risk patients. A novel method (Martin/Hopkins) using a patient-specific conversion factor provides more accurate LDL-C levels. However, this method has not been tested in proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor-treated patients. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.1533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143070PMC
August 2018
37 Reads

Citrulline Improves Early Post-Ischemic Recovery or Rat Hearts In Vitro by Shifting Arginine Metabolism From Polyamine to Nitric Oxide Formation.

Clin Med Insights Cardiol 2018 24;12:1179546818771908. Epub 2018 Apr 24.

Physiologisches Institut, Justus-Liebig-Universität Gießen, Gießen, Germany.

Background: Reperfusion or reopening of occluded vessels is the gold standard to terminate ischemia. However, early functional recovery after reperfusion is often low requiring inotropic intervention. Although catecholamines increase inotropy and chronotropy, they are not the best choice because they increase myocardial oxygen and substrate demand. Read More

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http://dx.doi.org/10.1177/1179546818771908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987901PMC
April 2018
5 Reads

Associations of Grip Strength and Change in Grip Strength With All-Cause and Cardiovascular Mortality in a European Older Population.

Clin Med Insights Cardiol 2018 20;12:1179546818771894. Epub 2018 Apr 20.

College of Population Studies, Chulalongkorn University, Bangkok, Thailand.

Objective: (1) To examine the associations between 3 measures of grip strength: static grip strength, change in grip strength, and the combination of grip strength and its change, with all-cause and cardiovascular mortality, and (2) to determine which measure is the most powerful predictor of all-cause and cardiovascular mortality among the European older population.

Method: Data come from the first 4 waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). A Cox proportional hazard model and a competing risk regression model were used to assess the associations. Read More

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http://dx.doi.org/10.1177/1179546818771894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987902PMC
April 2018
7 Reads

M-mode Diagnosis of Tachyarrhythmia Can be Erroneous Owing to "Pseudo 1:1 Atrioventricular Movement" of the Atrial Wall Adjacent to the Atrioventricular Valve Possibly due to Atrioventricular Constraint: A Case of Neonatal Atrial Flutter With 2:1 Atrioventricular Conduction.

Clin Med Insights Cardiol 2018 18;12:1179546818771700. Epub 2018 Apr 18.

Department of Pediatrics and Pediatric Cardiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.

M-mode echocardiography has been playing an important role in the diagnosis of fetal tachyarrhythmia. We recently encountered a neonatal case of atrial flutter with 2:1 atrioventricular conduction. However, M-mode erroneously indicated 1:1 atrioventricular movement. Read More

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http://dx.doi.org/10.1177/1179546818771700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912266PMC
April 2018
8 Reads

Myocardial Infarction With No Obstructive Coronary Artery Disease: Angiographic and Clinical Insights in Patients With Premature Presentation.

Can J Cardiol 2018 04 17;34(4):468-476. Epub 2018 Jan 17.

Center for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada; Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada; Divisions of General Internal Medicine and Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

Background: Premature myocardial infarction (MI) is an increasingly prevalent cause of morbidity and mortality worldwide. A subset of patients, predominantly young women, present with MI with no obstructive coronary artery disease (MINOCA), a nomenclature gaining recognition. However, few data exist on presentation and prognosis according to the severity of coronary artery disease (CAD). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.01.004DOI Listing
April 2018
11 Reads

On the Diagnosis of Mycotic Aortic Aneurysms.

Clin Med Insights Cardiol 2018 20;12:1179546818759678. Epub 2018 Feb 20.

Department of Plastic, Reconstructive, and Hand Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objective: There is striking paucity in consensus on the terminology, definition, and diagnostic criteria of mycotic aortic aneurysms. This literature study aims to elucidate this scientific omission, discuss its consequences, and present a proposition for reporting items on this disease.

Methods: A systematic literature review on PubMed and Medline using and between 1850 and 2017 was performed. Read More

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http://dx.doi.org/10.1177/1179546818759678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824903PMC
February 2018
12 Reads

Hemostasis After Brachial Artery Access With the MynxGrip Device: A Case Report.

Clin Med Insights Cardiol 2018 20;12:1179546818759298. Epub 2018 Feb 20.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Purpose: Brachial access is occasionally used for endovascular procedures when other more established or safer ones (eg, femoral or radial) are contraindicated. Although manual compression is the standard of care after brachial arteriotomy, suboptimal compression may lead to bleeding or thrombosis. Arteriotomy closure devices have thus been proposed as an alternative means to achieve hemostasis after brachial arteriotomy. Read More

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http://dx.doi.org/10.1177/1179546818759298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824893PMC
February 2018
7 Reads

Cardiovascular Risk Factors and Atherogenic Indices in an Iranian Population: Birjand East of Iran.

Clin Med Insights Cardiol 2018 20;12:1179546818759286. Epub 2018 Feb 20.

Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

The alteration in serum lipid profile; increase in total cholesterol (TC), triacylglycerol (TAG), and low-density lipoprotein cholesterol (LDL-C); and reduction in high-density lipoprotein cholesterol (HDL-C) are key factors in cardiovascular disease progression. The high prevalence and severity of cardiovascular diseases require new screening tools for better evaluation. Atherogenic index (AI) (LDL-C/HDL-C) and coronary risk index (CRI) (TC/HDL-C) can be strong markers for predicting the risk of atherosclerosis and coronary heart disease and disclose the presence of LDL or TAG in the serum of related patients. Read More

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http://dx.doi.org/10.1177/1179546818759286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824902PMC
February 2018
9 Reads

New Insights Into the Use of the 12-Lead Electrocardiogram for Diagnosing Acute Myocardial Infarction in the Emergency Department.

Can J Cardiol 2018 02 29;34(2):132-145. Epub 2017 Nov 29.

Department of Emergency Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis, Minnesota, USA. Electronic address:

The 12-lead electrocardiogram (ECG) remains the most immediately accessible and widely used initial diagnostic tool for guiding management in patients with suspected myocardial infarction (MI). Although the development of high-sensitivity cardiac troponin assays has improved the rule-in and rule-out and risk stratification of acute MI without ST elevation, the immediate management of the subset of acute MI with acute coronary occlusion depends on integrating clinical presentation and ECG findings. Careful interpretation of the ECG might yield subtle features suggestive of ischemia that might facilitate more rapid triage of patients with subtle acute coronary occlusion or, conversely, in identification of ST-elevation MI mimics (pseudo ST-elevation MI patterns). Read More

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http://dx.doi.org/10.1016/j.cjca.2017.11.011DOI Listing
February 2018
33 Reads

Awareness of 'Systolic Anterior Motion' in Different Conditions.

Clin Med Insights Cardiol 2018 10;12:1179546817751921. Epub 2018 Jan 10.

Department of Cardiac Anaesthesia and Cardiac Surgery, Sir Ganga Ram Hospital, New Delhi, India.

Perioperative echocardiography, especially transesophageal echocardiography, is of paramount importance in evaluating and managing refractory hypotension, a potential cause of which is systolic anterior motion (SAM) of anterior mitral leaflet. Dynamically moving anterior mitral valve leaflet towards the left ventricular outflow tract (LVOT) is described as SAM. Although SAM was initially observed in patients with hypertrophic cardiomyopathy, it can also be seen in patients with complex dynamic anatomy of the left ventricle. Read More

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http://dx.doi.org/10.1177/1179546817751921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772485PMC
January 2018
10 Reads

Rationale and Design for a Monocentric Prospective Study: Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction (SAPAAD Study).

Clin Med Insights Cardiol 2018 8;12:1179546817751628. Epub 2018 Jan 8.

Department of Cardiology, CHU de Caen, Caen, France.

Previous studies showed good agreement between pacemaker respiratory disturbance index (RDI) and polysomnography for diagnosis of severe sleep apnea (SA). The aim of this study is to investigate the diagnostic accuracy of RDI compared with apnea-hypopnea index (AHI) from a cardiorespiratory sleep study for the diagnosis of severe SA within patients requiring a pacemaker and meeting diastolic dysfunction criteria. Secondary objectives are as follows: correlation between plasma aldosterone level and SA severity, diagnostic accuracy of RDI for moderate SA, prevalence of SA among patients with diastolic dysfunction, occurrence of arrhythmias, and improvement of RDI with continuous positive airway pressure therapy. Read More

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http://dx.doi.org/10.1177/1179546817751628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764134PMC
January 2018
15 Reads

Hospitalisation in Patients With Heart Failure With Preserved Ejection Fraction.

Clin Med Insights Cardiol 2018 8;12:1179546817751609. Epub 2018 Jan 8.

Department of Cardiovascular Medicine, The Alfred Hospital and Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.

Heart failure is highly prevalent with more than 50% of cases being patients with a preserved ejection fraction (HFPEF), a figure that is projected to increase due to the changing risk factor landscape, in particular the ageing population. Overall mortality is similar to patients with heart failure with reduced ejection fraction (HFREF), as are the rates of hospitalisation. Patients with HFPEF have more comorbid conditions with fewer therapeutic options available. Read More

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http://journals.sagepub.com/doi/10.1177/1179546817751609
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http://dx.doi.org/10.1177/1179546817751609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764137PMC
January 2018
10 Reads

Is Exercise Training Appropriate for Patients With Advanced Heart Failure Receiving Continuous Inotropic Infusion? A Review.

Clin Med Insights Cardiol 2018 3;12:1179546817751438. Epub 2018 Jan 3.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Exercise-based rehabilitation programs have been reported to have beneficial effects for patients with heart failure. However, there is little evidence about whether this is the case in patients with more severe heart failure. In particular, there is a question in the clinical setting whether patients with advanced heart failure and continuous inotropic infusion should be prescribed exercise training. Read More

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http://dx.doi.org/10.1177/1179546817751438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757424PMC
January 2018
13 Reads

Manually Steerable Catheter With Improved Agility.

Clin Med Insights Cardiol 2018 4;12:1179546817751432. Epub 2018 Jan 4.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Purpose: A prototype steerable catheter was designed for endovascular procedures. This technical pilot study reports the initial experience using the catheter for cannulation of visceral arteries.

Technique: The 7F catheter was manually steerable with operator control handle for bending and rotation of the tip. Read More

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http://dx.doi.org/10.1177/1179546817751432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758962PMC
January 2018
13 Reads

Patients With Intermittent Claudication and Chronic Widespread Pain Improves in Health-Related Quality of Life After Invasive but Not After Noninvasive Treatment.

Clin Med Insights Cardiol 2017 20;11:1179546817747528. Epub 2017 Dec 20.

Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.

Background: Intermittent claudication (IC) is traditionally managed with risk factor modification, best medical treatment (BMT), and exercise training. Comorbidities such as diabetes and ischemic heart disease affect both results of invasive treatment and health-related quality of life (HRQoL) negatively. It is unknown how chronic widespread pain (CWP) influences the results of invasive treatment. Read More

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http://dx.doi.org/10.1177/1179546817747528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751902PMC
December 2017
11 Reads

Improvements in Regional Left Ventricular Function Following Late Percutaneous Coronary Intervention for Anterior Myocardial Infarction.

Clin Med Insights Cardiol 2017 17;11:1179546817746636. Epub 2017 Dec 17.

Department of Cardiology, University of Florence, Florence, Italy.

Background: Late revascularization following a myocardial infarction has questionable clinical benefit.

Methods: We studied 13 patients with anterior wall myocardial infarction who underwent percutaneous coronary intervention within 2 weeks of the primary event, by quantitative analysis of 2-dimensional echocardiographic images. Endocardial segmentations of the left ventricular (LV) endocardium from the 4-chamber views were studied over time to establish cumulative wall displacements (CWDs) throughout the cardiac cycle. Read More

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http://dx.doi.org/10.1177/1179546817746636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751905PMC
December 2017
12 Reads

Peripheral Artery Occlusive Disease Among Patients With Chronic Myeloid Leukemia Receiving Tyrosine Kinase Inhibitors: A Cross-Sectional Case-Control Study.

Clin Med Insights Cardiol 2017 15;11:1179546817747258. Epub 2017 Dec 15.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: There were some reports of peripheral artery occlusive disease (PAOD) associated with nilotinib usage in chronic myeloid leukemia (CML). These complications in other tyrosine kinase inhibitors are revealed as unknown.

Materials And Methods: We determined the prevalence of PAOD in patients with CML as compared with matched-control population by cross-sectional case-control study. Read More

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http://dx.doi.org/10.1177/1179546817747258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734569PMC
December 2017
16 Reads

Takotsubo Cardiomyopathy Precipitated by Tapering of Anxiolytic Medication: A Case Report.

Clin Med Insights Cardiol 2017 10;11:1179546817746643. Epub 2017 Dec 10.

Department of Cardiology, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.

Takotsubo cardiomyopathy is a transient apical ballooning of the left ventricle typically with electrocardiographic changes and enzyme release without evidence of obstructive coronary artery disease. It typically occurs in postmenopausal women and may have a predilection for patients with anxiety disorders. The following is a case in which we believe takotsubo cardiomyopathy was induced by the tapering of antianxiety medications. Read More

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http://dx.doi.org/10.1177/1179546817746643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731616PMC
December 2017
11 Reads

Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria.

Clin Med Insights Cardiol 2017 10;11:1179546817746632. Epub 2017 Dec 10.

Cardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

Background: Hypertensive heart failure (HHF) is the commonest form of heart failure in Nigeria. There is paucity of data in Nigeria on 24-hour Holter electrocardiography (24-HHECG) and important predictors of arrhythmias among HHF patients.

Objectives: To determine the 24-HHECG characteristics among HHF patients. Read More

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http://dx.doi.org/10.1177/1179546817746632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731613PMC
December 2017
24 Reads

Calcium Dynamics and Cardiac Arrhythmia.

Clin Med Insights Cardiol 2017 3;11:1179546817739523. Epub 2017 Dec 3.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

This Special Collection will gather all studies highlighting recent advances in theoretical and experimental studies of arrhythmia, with a specific focus on research seeking to elucidate links between calcium homeostasis in cardiac cells and organ-scale disruption of heart rhythm. Read More

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http://dx.doi.org/10.1177/1179546817739523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718302PMC
December 2017
13 Reads

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation: Insights and Results From the PLATINUM Diversity and PROMUS Element Plus Post-Approval Study Pooled Analysis.

JAMA Cardiol 2017 Dec;2(12):1303-1313

Mount Sinai Medical Center, New York, New York.

Importance: There exist limited outcomes data for women and minorities after contemporary percutaneous coronary intervention (PCI).

Objective: To examine 1-year outcomes in women and minorities vs white men after PCI with everolimus-eluting stents.

Design, Settings, And Participants: The PLATINUM Diversity study was a single-arm study enrolling women and minorities. Read More

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http://dx.doi.org/10.1001/jamacardio.2017.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814993PMC
December 2017
30 Reads

Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease.

Clin Med Insights Cardiol 2017 21;11:1179546817731110. Epub 2017 Sep 21.

Molecular Biology and Biochemistry Department, State Medical School of São José Rio Preto (FAMERP), São José do Rio Preto, Brazil.

This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. Read More

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http://dx.doi.org/10.1177/1179546817731110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613840PMC
September 2017
16 Reads

Treatment With Tafamidis Slows Disease Progression in Early-Stage Transthyretin Cardiomyopathy.

Clin Med Insights Cardiol 2017 18;11:1179546817730322. Epub 2017 Sep 18.

Global Product Development, Pfizer Inc, New York, NY, USA.

Background: Transthyretin cardiomyopathy (TTR-CM) is a progressive, fatal disease caused by the accumulation of misfolded transthyretin (TTR) amyloid fibrils in the heart. Tafamidis is a kinetic stabilizer of TTR that inhibits misfolding and amyloid formation.

Methods: In this post hoc analysis, data from an observational study (Transthyretin Amyloidosis Cardiac Study; n = 29) were compared with an open-label study of tafamidis in patients with TTR-CM (Fx1B-201; n = 35). Read More

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http://dx.doi.org/10.1177/1179546817730322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606341PMC
September 2017
12 Reads

Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial.

Can J Cardiol 2017 10 31;33(10):1274-1282. Epub 2017 Jul 31.

Department of Medicine, Montreal Heart Institute, Montreal, Québec, Canada. Electronic address:

Background: Studies comparing biventricular (BiV) cardiac resynchronization therapy (CRT) and left ventricular (LV) pacing alone have yielded conflicting results. We recently reported the results of the Greater Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) trial demonstrating similar clinical benefits of BiV and LV-CRT on exercise tolerance. We report the prespecified secondary outcomes of the GREATER-EARTH trial, comparing the impact of BiV vs LV-CRT on structural and biochemical cardiac remodelling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X173085
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http://dx.doi.org/10.1016/j.cjca.2017.07.478DOI Listing
October 2017
22 Reads

Role of Computational Modelling in Planning and Executing Interventional Procedures for Congenital Heart Disease.

Can J Cardiol 2017 09 3;33(9):1159-1170. Epub 2017 Jun 3.

Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia. Electronic address:

Increasingly, computational modelling and numerical simulations are used to help plan complex surgical and interventional cardiovascular procedures in children and young adults with congenital heart disease. From its origins more than 30 years ago, surgical planning with analysis of flow hemodynamics and energy loss/efficiency has helped design and implement many modifications to existing techniques. On the basis of patient-specific medical imaging, surgical planning allows accurate model production that can then be manipulated in a virtual surgical environment, with the proposed solutions finally tested with advanced computational fluid dynamics to evaluate the results. Read More

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http://dx.doi.org/10.1016/j.cjca.2017.05.024DOI Listing
September 2017
19 Reads

Pacing Spikes All Over.

Clin Med Insights Cardiol 2017 23;11:1179546817714478. Epub 2017 Jun 23.

Arrhythmia Services, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Ventricular safety pacing (VSP) is used to avoid cross talk by delivering ventricular stimulus shortly after an atrial-paced event if ventricular-sensed event occurs. Although VSP is a protective feature that exists for decades in different pacing devices, there are some reports of unfavorable outcomes of this algorithm. More so, health care providers sometimes face difficulties in interpreting and dealing with VSP strips. Read More

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http://dx.doi.org/10.1177/1179546817714478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484548PMC
June 2017
11 Reads

Effect of Chronic Hepatitis C Virus Treatment by Combination Therapy on Cardiovascular System.

Clin Med Insights Cardiol 2017 22;11:1179546817713204. Epub 2017 Jun 22.

Al-Sahel Teaching Hospital, Cardiology Department Cairo, Egypt.

Background: The prevalence of hepatitis C virus (HCV) in Egypt is quite high, and the combined oral direct-acting antiviral agents (DAAs) may have impressive results.

Objective: To assess the cardiovascular effects of DAAs in patients with HCV.

Methods: A total of 170 patients with HCV were divided into 2 groups: first group (100 patients) received triple combination therapy (pegylated interferon alfa, sofosbuvir, and ribavirin, whereas the second group (70 patients) received dual combination therapy (sofosbuvir and simeprevir). Read More

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http://dx.doi.org/10.1177/1179546817713204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484549PMC
June 2017
13 Reads

Temporal Changes in the Racial Gap in Survival After In-Hospital Cardiac Arrest.

JAMA Cardiol 2017 Sep;2(9):976-984

Division of Cardiovascular Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City.

Importance: Previous studies have found marked differences in survival after in-hospital cardiac arrest by race. Whether racial differences in survival have narrowed as overall survival has improved remains unknown.

Objectives: To examine whether racial differences in survival after in-hospital cardiac arrest have narrowed over time and if such differences could be explained by acute resuscitation survival, postresuscitation survival, and/or greater temporal improvement in survival at hospitals with higher proportions of black patients. Read More

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http://dx.doi.org/10.1001/jamacardio.2017.2403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710174PMC
September 2017
38 Reads

Cardiac Rehabilitation for Patients With Coronary Artery Disease: A Practical Guide to Enhance Patient Outcomes Through Continuity of Care.

Clin Med Insights Cardiol 2017 12;11:1179546817710028. Epub 2017 Jun 12.

Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, VIC, Australia.

Coronary artery disease (CAD) is a leading cause of disease burden worldwide. Referral to cardiac rehabilitation (CR) is a class I recommendation for all patients with CAD based on findings that participation can reduce cardiovascular and all-cause mortality, as well as improve functional capacity and quality of life. However, programme uptake remains low, systematic progression through the traditional CR phases is often lacking, and communication between health care providers is frequently suboptimal, resulting in fragmented care. Read More

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http://dx.doi.org/10.1177/1179546817710028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470863PMC
June 2017
21 Reads

Trends and Outcomes of Off-label Use of Transcatheter Aortic Valve Replacement: Insights From the NCDR STS/ACC TVT Registry.

JAMA Cardiol 2017 Aug;2(8):846-854

Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas.

Importance: Transcatheter aortic valve replacement (TAVR) was approved by the US Food and Drug Administration for severe aortic stenosis in patients who cannot undergo surgery and for patients at high operative risk. Use of TAVR for off-label indications has not been previously reported.

Objective: To evaluate patterns and adverse outcomes of off-label use of TAVR in US clinical practice. Read More

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http://dx.doi.org/10.1001/jamacardio.2017.1685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710589PMC
August 2017
21 Reads

Histologic Sequelae of Apical Hypertrophic Cardiomyopathy: Dystrophic Calcification.

Clin Med Insights Cardiol 2017 29;11:1179546817710934. Epub 2017 May 29.

Multimodality Cardiovascular Imaging Laboratory, Department of Cardiology, Hofstra Northwell School of Medicine, Manhasset, NY, USA.

We present cardiac computed tomography (CT) findings demonstrating apical hypertrophic cardiomyopathy with dystrophic calcification of the left ventricular apex. The absence of significant epicardial coronary artery disease demonstrated by coronary CT angiography suggests that increased wall tension and decreased microvascular perfusion over time account for the dyskinetic apical myocardium, rather than myocardial infarction secondary to atherosclerotic plaque rupture. These observations support CT as the imaging modality of choice to visualize the deposition of calcium in injured myocardial tissue, a recognized occurrence in chronically infarcted myocardium. Read More

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http://dx.doi.org/10.1177/1179546817710934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457028PMC
May 2017
34 Reads

The Genetics of Aortopathies in Clinical Cardiology.

Clin Med Insights Cardiol 2017 30;11:1179546817709787. Epub 2017 May 30.

Yale Cardiovascular Genetics Program, Yale Cardiovascular Research Center, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA.

Aortopathies pose a significant healthcare burden due to excess early mortality, increasing incidence, and underdiagnosis. Understanding the underlying genetic causes, early diagnosis, timely surveillance, prophylactic repair, and family screening are keys to addressing these diseases. Next-generation sequencing continues to expand our understanding of the genetic causes of heritable aortopathies, rapidly clarifying their underlying molecular pathophysiology and suggesting new potential therapeutic targets. Read More

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http://dx.doi.org/10.1177/1179546817709787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457142PMC
May 2017
24 Reads

Cardiovascular Magnetic Resonance Imaging-Incremental Value in a Series of 361 Patients Demonstrating Cost Savings and Clinical Benefits: An Outcome-Based Study.

Clin Med Insights Cardiol 2017 19;11:1179546817710026. Epub 2017 May 19.

Department of Cardiovascular Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.

Background: This study was designed to assess the clinical impact and cost-benefit of cardiovascular magnetic resonance imaging (CMR). In the face of current health care cost concerns, cardiac imaging modalities have come under focused review. Data related to CMR clinical impact and cost-benefit are lacking. Read More

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http://dx.doi.org/10.1177/1179546817710026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439571PMC
May 2017
22 Reads