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    110 results match your criteria Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders [Journal]

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    Retrocalcaneal Bursitis Precedes or Accompanies Achilles Tendon Enthesitis in the Early Phase of Rheumatoid Arthritis.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 5;11:1179544118781094. Epub 2018 Jun 5.
    Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan.
    The consecutive reports and stored images of ultrasound examinations for 100 symptomatic ankles of 74 patients with rheumatoid arthritis (RA) were reviewed for the presence or absence of retrocalcaneal bursitis (RCB) and Achilles tendon enthesitis (ATE). The ankles were classified into 4 categories based on the presence or absence of RCB or ATE. The number of RCB(-)/ATE(-), RCB(+)/ATE(-), RCB(+)/ATE(+), and RCB(-)/ATE(+) ankles was 62, 16, 12, and 10, respectively. Read More

    A Pooled Analysis of Two Multicenter, Randomized Controlled Trials of a Single Intra-articular Injection of Gel-200 for Treatment of Osteoarthritis of the Knee.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 9;11:1179544118773068. Epub 2018 May 9.
    Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA.
    Background And Objective: To perform an integrated analysis of 2 randomized controlled trials (RCTs) to assess the efficacy and safety of a single intra-articular injection of Gel-200 compared with phosphate buffered saline (PBS) for treatment of osteoarthritis of the knee.

    Methods: Data from the intention-to-treat (ITT) populations of both RCTs were pooled for this integrated analysis. Mean changes from baseline in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain subscores were assessed using a longitudinal model; treatment differences were compared between intra-articular Gel-200 and PBS injections. Read More

    Late Presentation of Infected Silicone Granulomas in the Lower Limb.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 22;11:1179544118759020. Epub 2018 Feb 22.
    Department of Pathology, Royal Free Hospital, London, UK.
    Introduction: Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation. Read More

    An Observational 1-Month Trial on the Efficacy and Safety of Promerim for Improving Knee Joint.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 11;11:1179544118757496. Epub 2018 Feb 11.
    Şişli Hamidiye Etfal Training and Research Hospital, Orthopedics, Istanbul, Turkey.
    Objective: This study was conducted to evaluate the efficacy and tolerability of the oral intake of promerim in the elimination of acute pain and discomfort associated with knee osteoarthritis (OA).

    Methods: Single-center, 1-month, prospective, observational clinical trial. A total of 92 patients not older than 70 years were included. Read More

    Osteoarthritis and the Complement Cascade.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 3;11:1179544117751430. Epub 2018 Jan 3.
    Department of Anatomy, Paracelsus Medical University, Nuremberg, Germany.
    Accumulating evidence demonstrates that complement activation is involved in the pathogenesis of osteoarthritis (OA). However, the intimate complement regulation and cross talk with other signaling pathways in joint-associated tissues remain incompletely understood. Recent insights are summarized and discussed here, to put together a more comprehensive picture of complement involvement in OA pathogenesis. Read More

    Total Knee Arthroplasty: Does Day of Surgery Matter?
    Clin Med Insights Arthritis Musculoskelet Disord 2018 15;11:1179544117754067. Epub 2018 Jan 15.
    Section of Orthopaedic Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Sindh, Pakistan.
    Introduction: There has been an influx of research studies aimed at identifying all factors that contribute to minimizing cost and maximizing postoperative care after total knee arthroplasty (TKA). Length of stay (LOS) has been defined as a significant factor that contributes to increased burden. We aimed at looking whether day of surgery has any significant effect on the LOS and postoperative complications following total knee arthroplasty (TKA). Read More

    A Preliminary Evaluation of the Ability of Keratotic Tissue to Act as a Prognostic Indicator of Hip Fracture Risk.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 16;11:1179544117754050. Epub 2018 Jan 16.
    Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.
    Studies have shown that Raman spectroscopic analysis of fingernail clippings can help differentiate between post-menopausal women who have and who have not suffered a fracture. However, all studies to date have been retrospective in nature, comparing the proteins in nails sourced from women, post-fracture. The objective of this study was to investigate the potential of a prospective test for hip fracture based on spectroscopic analysis of nail tissue. Read More

    The Protein Tyrosine Phosphatase Nonreceptor 22 () R620W Functional Polymorphism in Psoriasis.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 11;11:1179544117751434. Epub 2018 Jan 11.
    Scientific Research Center, Medical Services Department for Armed Forces, Riyadh, Saudi Arabia.
    Background: Psoriasis is a complex autoimmune disease caused by the interaction of genetic and environmental factors. gene polymorphism has been reported to affect psoriasis susceptibility; however, no data are available for Middle Eastern populations.

    Objective: The aim of this study was to investigate the association of PTPN22 (1858C/T) R620W polymorphism with psoriasis in a Saudi cohort. Read More

    Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
    Clin Med Insights Arthritis Musculoskelet Disord 2018 8;11:1179544117751627. Epub 2018 Jan 8.
    Laboratory of Biochemistry and Immunology, Faculty of Sciences, Mohammed V University Agdal, Rabat, Morocco.
    The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Read More

    Rheological Properties of Commercially Available Hyaluronic Acid Products in the United States for the Treatment of Osteoarthritis Knee Pain.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 3;11:1179544117751622. Epub 2018 Jan 3.
    Department of Orthopaedics & Rehabilitation, NewYork Presbyterian/Queens; Departments of Orthopaedic Surgery and Rehabilitation Medicine, Weill Cornell Medical College of Cornell University, New York, NY, USA.
    Objective: The inconsistent results within the current literature regarding the efficacy of intra-articular-hyaluronic acid (IA-HA) for the treatment of knee osteoarthritis (OA) have been suggested to be due to intrinsic differences between individual HA products. The purpose of this investigation is to define the rheological differences between currently available HA products in the United States at the time of this study for the treatment of knee OA, which will help elaborate on the appropriateness of classifying HA products as a class opposed to as individual agents.

    Methods: The rheological parameters for Euflexxa, Orthovisc, Supartz, Monovisc, Synvisc, Synvisc-One, Gel-One, and Hyalgan were obtained with a TA AR 2000 EX Rheometer with a cone-plate geometry (40-mm plate diameter and a 2° cone angle) at room temperature. Read More

    Medial Pivot in Total Knee Arthroplasty: Literature Review and Our First Experience.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 4;11:1179544117751431. Epub 2018 Jan 4.
    Department of Orthopaedics and Traumatology, Città della Salute e della Scienza di Torino, CTO Hospital, Turin, Italy.
    Background: Traditional total knee implants designs, usually, are not able to reproduce the physiological kinematics of the knee, leaving almost 20% of the patients, those who underwent a total knee arthroplasty (TKA), not fully satisfied. Modern inserts are nowadays designed with a fully congruent medial compartment to reproduce the normal medial pivoting biomechanics of the knee. The aim of this article was to evaluate preliminary clinical improvement using the Medial Congruent (MC) insert as specific level of constraint. Read More

    Proliferative Synovitis of the Shoulder Bursae is a Key Feature for Discriminating Elderly Onset Rheumatoid Arthritis Mimicking Polymyalgia Rheumatica From Polymyalgia Rheumatica.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 7;10:1179544117745851. Epub 2017 Dec 7.
    Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan.
    Semiquantitative scoring for subacromial bursa (SAB), subdeltoid bursa (SDB), and subcoracoid bursa by both gray-scale (GS) and power Doppler (PD) ultrasonography was performed in 15 patients with polymyalgia rheumatica (PMR) (72.6 ± 7.7 years old) and 15 patients with elderly onset rheumatoid arthritis with PMR-like onset (pm-EORA) (70. Read More

    Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 10;10:1179544117733452. Epub 2017 Oct 10.
    Internal Medicine specialist, Shahid Beheshti University of medical science, Tehran, Iran.
    Background And Objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis.

    Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Read More

    Feasibility of the Atlas Unicompartmental Knee System Load Absorber in Improving Pain Relief and Function in Patients Needing Unloading of the Medial Compartment of the Knee: 1-Year Follow-Up of a Prospective, Multicenter, Single-Arm Pilot Study (PHANTOM High Flex Trial).
    Clin Med Insights Arthritis Musculoskelet Disord 2017 27;10:1179544117733446. Epub 2017 Sep 27.
    Sports Science Institute of South Africa, Capetown, South Africa.
    In young patients with medial knee osteoarthritis (OA), surgical intervention may not be desirable due to preferences to avoid bone cutting procedures, return to high activity levels, and prolong implant survival. The Atlas Knee System was designed to fill the gap between ineffective conservative treatments and invasive surgery. This single-arm study included 26 patients, aged 25 to 65 years, who completed 12 months of follow-up. Read More

    Patient Preferences Regarding Surgical Interventions for Knee Osteoarthritis.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 20;10:1179544117732039. Epub 2017 Sep 20.
    OrthoEvidence Inc., Burlington, ON, Canada.
    Surgical interventions for knee osteoarthritis (OA) have markedly different procedure attributes and may have dramatic differences in patient desirability. A total of 323 patients with knee OA were included in a dual response, choice-based conjoint analysis to identify the relative preference of 9 different procedure attributes. A model was also developed to simulate how patients might respond if presented with the real-world knee OA procedures, based on conservative assumptions regarding their attributes. Read More

    Magnetic Resonance Imaging of the Axial Skeleton in Patients With Spondyloarthritis: Distribution Pattern of Inflammatory and Structural Lesions.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 29;10:1179544117728081. Epub 2017 Aug 29.
    Department of Radiology, University Medical Center, Regensburg, Germany.
    Purpose: Spondyloarthritis is a chronic inflammatory disorder of the musculoskeletal system driven by systemic enthesitis and typically involving the axial skeleton, ie, the spine and the sacroiliac joints. The purpose of this study was to assess the distribution pattern of inflammatory and structural magnetic resonance imaging (MRI) findings in spondyloarthritis.

    Methods: Retrospective study of 193 patients with axial spondyloarthritis who received MRI of the spine and the sacroiliac joints. Read More

    Comparison of the 3 Different Injection Techniques Used in a Randomized Controlled Study Evaluating a Cross-Linked Sodium Hyaluronate Combined With Triamcinolone Hexacetonide (Cingal) for Osteoarthritis of the Knee: A Subgroup Analysis.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 14;10:1179544117725026. Epub 2017 Aug 14.
    CHU de Québec-Université Laval, Québec City, QC, Canada.
    A recent trial demonstrated that patients with knee osteoarthritis treated with a sodium hyaluronate and corticosteroid combination (Cingal) experienced greater pain reductions compared with those treated with sodium hyaluronate alone (Monovisc) or saline up to 3 weeks postinjection. In this study, injections were administered by 1 of 3 approaches; however, there is currently no consensus on which, if any, of these techniques produce a more favorable outcome. To provide additional insight on this topic, the results of the previous trial were reanalyzed to determine whether (1) the effect of Cingal was significant within each injection technique and (2) pain reductions were similar between injection techniques across all treatment groups. Read More

    The Disease-Modifying Effects of Hyaluronan in the Osteoarthritic Disease State.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 11;10:1179544117723611. Epub 2017 Aug 11.
    Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, ON, Canada.
    Hyaluronic acid (HA) has been a treatment modality for patients with knee osteoarthritis (OA) for many years now. Since HA was first introduced for the treatment of painful knee OA, much has been elucidated regarding both the etiology of this disease and the mechanisms by which HA may mitigate joint pain and tissue destruction. The objectives of this article are to (1) describe the etiology and pathophysiology of OA including both what is known about the genetics and biochemistry, (2) describe the role of HA on disease progression, (3) detail the antinociceptive and anti-inflammatory actions of HA in OA, and (4) present evidence of disease-modifying effects of HA in the preservation and restoration of the extracellular matrix. Read More

    Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 3;10:1179544117722763. Epub 2017 Aug 3.
    Rheumatology Department, Hospital Guillermo Almenara Irigoyen, La Victoria, Peru.
    Acute hypokalemic paralysis is a rare and potentially fatal condition, with few related causes, one of which highlights distal renal tubular acidosis (dRTA). Distal renal tubular acidosis is a rare complication of several autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome, and Hashimoto thyroiditis. We report a case of a lupic patient who presented rapidly progressive quadriparesis in the context of active renal disease. Read More

    Subacromial Anesthetics Increase Proprioceptive Deficit in the Shoulder and Elbow in Patients With Subacromial Impingement Syndrome.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 12;10:1179544117713196. Epub 2017 Jun 12.
    Department of Human Physiology, University of Oregon, Eugene, OR, USA.
    Shoulder proprioception gives information regarding arm joint position and movement direction. Several studies have investigated shoulder proprioceptive acuity in patients with subacromial impingement syndrome (SIS); however, differences in protocols and between-subjects designs have limited scientific inferences regarding proprioception and SIS. We aimed to determine within-subject differences in shoulder and elbow proprioceptive acuity in 17 patients with stage 2 SIS following treatment of a local anesthetic injection. Read More

    Cost-Utility of a Single-Injection Combined Corticosteroid-Hyaluronic Acid Formulation vs a 2-Injection Regimen of Sequential Corticosteroid and Hyaluronic Acid Injections.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 12;10:1179544117712993. Epub 2017 Jun 12.
    Department of Orthopaedics, The University of British Columbia, Vancouver, BC, Canada.
    Research has shown early and sustained relief with a combination therapy of a corticosteroid (CS) and hyaluronic acid (HA) in knee osteoarthritis (OA) patients. This can be administered via a single injection containing both products or as separate injections. The former may be more expensive when considering only product cost, but the latter incurs the additional costs and time of a second procedure. Read More

    Oral Anaerobic Bacteria in the Etiology of Ankylosing Spondylitis.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 12;10:1179544117712992. Epub 2017 Jun 12.
    Department of Physical Medicine and Rehabilitation, Uzunköprü State Hospital, Edirne, Turkey.
    Ankylosing spondylitis (AS) is associated with periodontitis. Anti- and anti- antibody titers were higher in patients with spondyloarthritis than in healthy people. Sulfasalazine is an effective antibiotic treatment for AS. Read More

    Sternocostoclavicular Hyperostosis: An Insufficiently Recognized Clinical Entity.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 6;10:1179544117702877. Epub 2017 Apr 6.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
    A 79-year-old male chronic hemodialysis patient with no history of central venous catheterization was referred to our hospital with progressive swelling of the left upper limb ipsilateral to a forearm arteriovenous fistula. Radiological assessments revealed marked hyperostosis in the ribs, sternum, and clavicles with well-developed ossification of the sternocostoclavicular ligaments. Such characteristic structural abnormalities and our failure to identify the left subclavian vein with contrast material despite the abundant dilated collaterals in the left shoulder area encouraged us to diagnose our patient with sternocostoclavicular hyperostosis (SCCH) complicated by central vein obstruction. Read More

    Ultrasound-Diagnosed Tibia Stress Fracture: A Case Report.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 10;10:1179544117702866. Epub 2017 Apr 10.
    Department of Sports Medicine, The State University of New Jersey, New Brunswick, NJ, USA.
    Stress fractures are a frequent cause of lower extremity pain in athletes, and especially in runners. Plain imaging has a low sensitivity. Magnetic resonance imaging (MRI) or bone scan scintigraphy is the criterion standard, but expensive. Read More

    Early Results of Minimally Invasive Percutaneous Plate Osteosynthesis for Fractures of the Distal Tibia: A Retrospective Case Series and Review of the Literature.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 30;10:1179544117701724. Epub 2017 Mar 30.
    Orthopaedic Department, Sunderland Royal Hospital, Sunderland, UK.
    Minimally invasive percutaneous plate osteosynthesis was developed on the concept that preservation of the soft tissue envelope during surgical management of distal tibial fractures is of paramount importance. We report on our early experience using this technique over a 1-year period with 14 such injuries that were treated by a locking compression plate via minimally invasive surgery. The surgical reduction was excellent in most of the cases and all fractures healed uneventfully. Read More

    A Double-Blind, Active-Controlled Clinical Trial of Sodium Bicarbonate and Calcium Gluconate in the Treatment of Bilateral Osteoarthritis of the Knee.
    Clin Med Insights Arthritis Musculoskelet Disord 2017 16;10:1179544116688899. Epub 2017 Feb 16.
    School of Natural Sciences, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico.
    Objective: To evaluate the effect of intra-articular injections of sodium bicarbonate with a single (SBCG1) or double dose (SBCG2) of calcium gluconate administered monthly compared with methylprednisolone (MP) for treatment of knee osteoarthritis.

    Methods: A 3-month, randomized, double-blind clinical trial with patients diagnosed with knee osteoarthritis (OA). The outcome variables were the Western Ontario-McMaster University Osteoarthritis Index (WOMAC) and the Lequesne functional index. Read More

    Relationship Between Lymph Node Volume and Pain Following Certolizumab Therapy for Rheumatoid Arthritis Flare: A Pilot Study.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 14;9:203-208. Epub 2016 Dec 14.
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.
    Objectives: The mechanisms that trigger flare in rheumatoid arthritis (RA) are unknown. In murine arthritis models, dysfunctional lymph node (LN) drainage is associated with joint flare. To examine if LN alterations are associated with RA flare, we analyzed the change in LN volume via contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with active joint flare at baseline and 16 weeks after certolizumab pegol (CZP) therapy. Read More

    Correction to "Macroscopical, Histological, and Characterization of Nonosteoarthritic Versus Osteoarthritic Hip Joint Cartilage".
    Clin Med Insights Arthritis Musculoskelet Disord 2016 7;9:201. Epub 2016 Dec 7.
    Department of Orthopaedic, Trauma and Reconstructive Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; Department of Anatomy, Paracelsus Medical University, Salzburg and Nuremberg, Nuremberg, Germany.
    [This corrects the article DOI: 10.4137/CMAMD.S29844. Read More

    Imaging Guidance Improves the Results of Viscosupplementation with HANOX-M-XL in Patients with Ankle Osteoarthritis: Results of a Clinical Survey in 50 Patients Treated in Daily Practice.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 22;9:195-199. Epub 2016 Nov 22.
    Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France.
    Background: The objective of this survey was to assess retrospectively the interest of performing viscosupplementation using imaging guidance in patients suffering from ankle osteoarthritis (OA).

    Patients And Methods: This is a multicenter retrospective survey using a standardized questionnaire. Fifty patients suffering from ankle OA and treated, in daily clinical practice, with a single intra-articular injection of a novel viscosupplement made of a combination of a non-animal cross-linked hyaluronan and mannitol, HANOX M-XL, were included in the survey. Read More

    Patellofemoral Joint Arthroplasty: Our Experience in Isolated Patellofemoral and Bicompartmental Arthritic Knees.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 15;9:189-193. Epub 2016 Nov 15.
    Department of Orthopaedics Citta della Salute e della Scienza, PO CTO, University of Study of Turin, Torino, Italy.
    Introduction: Isolated patellofemoral (PF) arthritis is rare, and there is no complete agreement about the best surgical treatment. The operative treatments are total knee arthroplasty and patellofemoral replacement (PFR). The incidence of many early complications of PF arthroplasty has decreased with the introduction of newer designs. Read More

    Rate of Proven Rheumatic Diseases in a Large Collective of Referrals to an Outpatient Rheumatology Clinic Under Routine Conditions.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 2;9:181-187. Epub 2016 Oct 2.
    Zentrum für Innere Medizin, Medizinische Klinik und Poliklinik II, University of Würzburg, Würzburg, Germany.; Diabetes Zentrum Mergentheim, Bad Mergentheim, Germany.
    The prognostic significance of early diagnosis and therapeutic intervention in inflammatory rheumatic diseases has been well documented. However, a shortage of rheumatologists often impedes this approach in clinical practice. Therefore, it is of importance to identify those patients referred for diagnosis who would benefit most from a specialist's care. Read More

    Standardized Follow-up of Patients with Symptomatic Knee Osteoarthritis Treated with a Single Intra-articular Injection of a Combination of Cross-Linked Hyaluronic Acid and Mannitol.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 25;9:175-9. Epub 2016 Sep 25.
    Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France.
    Objectives: The objective of this study is to obtain pilot data from daily practice conditions of a viscosupplement made of a cross-linked high-molecular-weight hyaluronic acid (HA) combined with mannitol in patients with knee osteoarthritis (KOA).

    Methods: The data of 40 consecutive patients, 29 women and 11 men, who were prospectively followed up for 6 months, using a standardized procedure, were retrospectively analyzed. All patients have received a single intra-articular injection of HAnox-M-XL (4. Read More

    Genetic Association of HLA-A*26, -A*31, and -B*51 with Behcet's Disease in Saudi Patients.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 8;9:167-73. Epub 2016 Aug 8.
    Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Background: HLA-B*51 has been universally associated with Behcet's disease (BD) susceptibility, while different alleles of HLA-A have also been identified as independent BD susceptibility loci in various ethnic populations. The objective of this study was to investigate associations of HLA-A and -B alleles with BD in Saudi patients.

    Materials And Methods: Genotyping for HLA-A and HLA-B was performed using HLA genotyping kit (Lab type((R)) SSO) in 120 Saudi subjects, including 60 BD patients and 60 matched healthy controls. Read More

    Reliability of a Proposed Ultrasonographic Grading Scale for Severity of Primary Knee Osteoarthritis.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 24;9:161-6. Epub 2016 Jul 24.
    Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Objectives: The objective of this study was to examine the concordance of a grading scale (0-4) of medial femoral osteophytes in knee joint detected by ultrasound (US) compared with the corresponding grades (0-4) of Kellgren-Lawrence (K&L) scale of conventional radiography and clinical joint examination.

    Patients And Methods: A cross-sectional observational study included 160 patients with knee pain who fulfilled the American College of Rheumatology (ACR) criteria for knee osteoarthritis (KOA) and 20 patients with knee pain who have not fulfilled the ACR criteria for KOA. All patients were subjected to clinical assessment (Western Ontario and McMaster Universities Index of Osteoarthritis and global visual analog scale) and radiological assessment in the form of X-ray grading according to K&L grading scale and ultrasonographic assessment of medial femoral osteophytes according to a scale that was proposed by the first author and consisted of five grades (0-4), where grade 0 denoted no osteoarthritis and grade 4 denoted the most advanced grade of KOA. Read More

    A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 7;9:139-59. Epub 2016 Jul 7.
    Center for Healing and Regenerative Medicine, Austin, TX, USA.
    Objective: The aim of this study was to systematically review dextrose (d-glucose) prolotherapy efficacy in the treatment of chronic musculoskeletal pain.

    Data Sources: Electronic databases PubMed, Healthline, OmniMedicalSearch, Medscape, and EMBASE were searched from 1990 to January 2016.

    Study Selection: Prospectively designed studies that used dextrose as the sole active prolotherapy constituent were selected. Read More

    Raman Spectroscopic Analysis of Fingernail Clippings Can Help Differentiate Between Postmenopausal Women Who Have and Have Not Suffered a Fracture.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 31;9:109-16. Epub 2016 May 31.
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.; Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.
    Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results from the validation set showed that a novel algorithm, combining spectroscopy data with clinical data, provided area under the curve (AUC) of 74% compared to an AUC of 60% from a reduced QFracture score (a clinically accepted risk calculator) and 61% from the dual-energy X-ray absorptiometry T-score, which is in current use for the diagnosis of osteoporosis. Read More

    Effects of Nasal Calcitonin vs. Oral Gabapentin on Pain and Symptoms of Lumbar Spinal Stenosis: A Clinical Trial Study.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 5;9:133-8. Epub 2016 Jul 5.
    School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Lumbar spinal stenosis (LSS) is a chronic and prevalent disease that occurs in 10.8% of the general population, mostly in old age. We designed the first clinical trial study to compare the effects of administering the nasal salmon calcitonin spray and gabapentin in patients with LSS. Read More

    Differences Regarding Branded HA in Italy, Part 2: Data from Clinical Studies on Knee, Hip, Shoulder, Ankle, Temporomandibular Joint, Vertebral Facets, and Carpometacarpal Joint.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 7;9:117-31. Epub 2016 Jun 7.
    Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, Tor Vergata University, Rome, Italy.
    Objectives: The aim of the current study is to collect scientific data on all branded hyaluronic acid (HA) products in Italy that are in use for intra-articular (IA) injection in osteoarthritis (OA) compared with that reported in the leaflet.

    Methods: An extensive literature research was performed for all articles reporting data on the IA use of HA in OA. Selected studies were taken into consideration only if they are related to products based on HAs that are currently marketed in Italy with the specific joint indication for IA use in patients affected by OA. Read More

    Case Study: Giant Cell Arteritis with Vertebral Artery Stenosis.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 29;9:103-7. Epub 2016 May 29.
    Box Hill Hospital, Box Hill, VIC, Australia.
    In giant cell arteritis (GCA), involvement of the vertebral arteries is rare with reported rates of 3%-4% for ischemic events secondary to vertebral artery stenosis or occlusion for those patients with GCA. This case study describes a patient who initially presented with acute onset of vertigo but was also found to have transient, side-alternating upper limb neurological findings. While initial imaging showed no vascular abnormalities, it was not until GCA was eventually confirmed with a temporal artery biopsy that the initial scans were shown to have bilateral narrowing of the vertebral arteries. Read More

    Differences among Branded Hyaluronic Acids in Italy, Part 1: Data from In Vitro and Animal Studies and Instructions for Use.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 25;9:89-101. Epub 2016 May 25.
    Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, Tor Vergata University, Rome, Italy.
    Background: The use of hyaluronic acid (HA) for intra-articular (IA) injection is widespread around the world for patients affected by osteoarthritis.

    Aim: The aim of this study is to identify scientific evidence from in vitro and in vivo studies supporting the use of IA HAs marketed in Italy. We also evaluated the accuracy of indications and contraindications reported in the leaflets of such HAs compared with the available scientific evidence. Read More

    Apolipoprotein E Gene Polymorphisms in Saudi Patients with Systemic Lupus Erythematosus.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 22;9:81-7. Epub 2016 May 22.
    Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Apolipoprotein E (APOE) is a glycosylated protein with multiple biological properties. APOE gene polymorphism plays a central role in lipid metabolism and has recently been suggested to regulate inflammation. Our objective is to evaluate whether APOE polymorphism affects susceptibility to SLE. Read More

    Hip Fracture Types in Canadian Men and Women Change Differently with Age: A Population-Level Analysis.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 3;9:75-9. Epub 2016 May 3.
    Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.
    Background: We have previously reported a gender difference in the occurrence of hip fracture type with age in our local population. In the current report, we have explored this phenomenon in a Canadian population using five years of data from a national administrative database. We have compared community-dwelling and institutionalized individuals to determine if frailty is important and has a differential effect on the type of hip fracture experienced. Read More

    Macroscopical, Histological, and In Vitro Characterization of Nonosteoarthritic Versus Osteoarthritic Hip Joint Cartilage.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 3;9:65-74. Epub 2016 May 3.
    Department of Orthopaedic, Trauma and Reconstructive Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; Department of Anatomy, Paracelsus Medical University, Salzburg and Nuremberg, Nuremberg, Germany.
    Osteoarthritis (OA) might affect chondrocyte culture characteristics and complement expression. Therefore, this study addressed the interrelation between macroscopical and microscopical structure, complement expression, and chondrocyte culture characteristics in non-OA and OA cartilage. Femoral head cartilage samples harvested from patients with femoral neck fractures (FNFs) and OA were analyzed for macroscopical alterations using an in-house scoring system, graded histologically (Mankin score), and immunolabeled for complement regulatory proteins (CRPs) and receptors. Read More

    Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 28;9:57-63. Epub 2016 Apr 28.
    Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
    This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier. Read More

    Analysis of Mitogen-Activated Protein Kinases in Bone and Cartilage of Patients with Rheumatoid Arthritis Treated with Abatacept.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 10;9:51-6. Epub 2016 Apr 10.
    Department of Orthopaedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.
    The aim of this study was to analyze the histological changes related to mitogen-activated protein (MAP) kinases in bone and cartilage treated with abatacept for rheumatoid arthritis (RA). A total of 20 patients of bone and cartilage were assessed: 10 abatacept with methotrexate (MTX)-treated RA patients were compared with 10 MTX-treated RA patients (control). The histology of bone and cartilage was observed by staining with hematoxylin and eosin and analyzed immunohistochemically for the expression of tumor necrosis factor-α, interleukin-6, CD4 (T cell), CD68 (macrophage), receptor activator of nuclear kappa-B ligand, osteoprotegerin, osteopontin, CD29 (β-1 integrin), phospho-p38 MAPK (Tyr180/Tyr182), phospho-p44/42 MAPK (extracellular signal-regulated kinase, ERK1/ERK2), and phosphor-c-Jun N-terminal kinase. Read More

    Simultaneous Treatment with Subcutaneous Injection of Golimumab and Intra-articular Injection of Triamcinolone Acetonide (K-Method) in Patients with Rheumatoid Arthritis Undergoing Switching of Biologics: Retrospective Case-Control Study.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 4;9:45-9. Epub 2016 Apr 4.
    Department of Orthopedic Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
    Background: Tight control of severe rheumatoid arthritis (RA) in patients with high disease activity, even when using biologics, is sometimes difficult using a treat-to-target strategy. Switching from one biologic to another is associated with lower efficacy than that in treatment-naive cases. We developed the K-method that involves simultaneous treatment with golimumab and intra-articular joint injection of triamcinolone acetonide (TA) in patients undergoing switching of biologics. Read More

    Reduction in Serum Uric Acid May Be Related to Methotrexate Efficacy in Early Rheumatoid Arthritis: Data from the Canadian Early Arthritis Cohort (CATCH).
    Clin Med Insights Arthritis Musculoskelet Disord 2016 4;9:37-43. Epub 2016 Apr 4.
    Rheumatology, Western University, London, ON, Canada.
    Objectives: The mechanism of action of methotrexate in rheumatoid arthritis (RA) is complex. It may increase adenosine levels by blocking its conversion to uric acid (UA). This study was done to determine if methotrexate lowers UA in early RA (ERA). Read More

    Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 7;9:29-36. Epub 2016 Mar 7.
    Department of Histopathology, Faculty of Medicine, Minia University, Minia, Egypt.
    Aim Of The Work: This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN).

    Patients And Methods: A total of 60 systemic lupus erythematosus (SLE) patients were compared to 20 healthy controls. Urinary and serum IL-6 were measured in both patients and controls. Read More

    Clinicians' Perspectives on the Use of Intra-Articular Hyaluronic Acid as a Treatment for Knee Osteoarthritis: A North American, Multidisciplinary Survey.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 21;9:21-7. Epub 2016 Feb 21.
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.
    Introduction: This study aims to describe the perceptions of orthopedic surgeons on the efficacy of intra-articular hyaluronic acid (IA-HA), the influence of IA-HA product characteristics on its efficacy, and to identify patterns and factors related to the use of IA-HA. Additionally, this study examines factors that influence IA-HA brand selection, focusing on Euflexxa(®) (1% sodium hyaluronate).

    Methods: We developed survey questions by reviewing the current literature and consulting with experts on the use of IA-HA in the management of knee osteoarthritis (OA). Read More

    Ochronotic Arthropathy: Two Case Reports from a Developing Country.
    Clin Med Insights Arthritis Musculoskelet Disord 2016 9;9:15-20. Epub 2016 Feb 9.
    Department of Rehabilitation Medicine, Combined Military Hospital, Panno Aqil Cantt, Pakistan.
    Alkaptonuria is a rare inborn error of metabolism, which is classified as an orphan disease. It is due to the lack of an enzyme homogentisate 1,2-dioxygenase, which results in an accumulation of homogentisic acid in different areas of the body, including sclera, skin, cardiac valves, articular cartilage of the large joints and intervertebral disks. We present two cases of alkaptonuria resulting in ochronotic arthropathy with advanced secondary generalized osteoarthritis, intervertebral disk calcifications, skin and scleral pigmentation. Read More

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