1,320,635 results match your criteria Clinical Medicine & Research [Journal]


Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System.

Thorac Cardiovasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Morfology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, Sant'Anna Hospital, University of Ferrara, Ferrara, Italy.

Background:  This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease.

Methods:  Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Read More

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http://dx.doi.org/10.1055/s-0039-1678612DOI Listing
February 2019

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery, University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, AUSTRALIA.

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c4DOI Listing
February 2019

A comparison of exhaled breath online and offline measurements for diabetes pre-screening by graphene-based sensor: from powder processing to clinical monitoring prototype.

J Breath Res 2019 Feb 22. Epub 2019 Feb 22.

SRM University, Kattankulathur, Tamil Nadu, INDIA.

Several breath analysis studies have suggested a correlation between blood glucose (BG) levels and breath acetone, indicating acetone as a primary biomarker in exhaled breath for diabetes diagnosis. Herein, we have (i) fabricated and validated graphene based chemi-resistive sensors for selective and sensitive detection of acetone, (ii) performed offline breath analysis by static gas sensing setup to acquire olfactory signal and (iii) developed an LED based portable on/off binary e-nose system for pre-screening diabetes through online analysis. The fabricated sensors showed selective detection for acetone with high sensitivity (5. Read More

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http://dx.doi.org/10.1088/1752-7163/ab09aeDOI Listing
February 2019

VarGrouper - a Bioinformatic Tool for Local Haplotyping of Deletion-Insertion Variants from Next-generation Sequencing Data Post Variant Calling.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, Harvard Medical School / Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Accurate genetic variant representation through nomenclature and annotation is essential for understanding functional consequence and properly noting the presence of variants across time, assays, and laboratories. Current variant calling algorithms detect single deletion-insertion variants as multiple indel and/or substitution variants from next-generation sequencing data. Consequently, these variants are separately annotated in bioinformatics pipelines, leading to inaccurate variant representation. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.12.003DOI Listing
February 2019

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Division of Clinical Pharmacology.

The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients. Testing methods for variants in ABCB1, CBR3, COMT, CYP3A7, C8ORF34, FCGR2A, FCGR3A, HAS3, NT5C2, NUDT15, SBF2, SEMA3C, SLC16A5, SLC28A3, SOD2, TLR4, and TPMT were validated in a CLIA-accredited laboratory. As no known reference materials were available, DNA samples that were from Coriell Cell Repositories (Camden, NJ) were used for the analytical validation studies. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.009DOI Listing
February 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Hematopathology, The University of Texas MD Anderson Cancer Center, Houston; Baylor Miraca Genetics Laboratories. Electronic address:

The emergence of highly sensitive molecular diagnostic approaches such as droplet digital PCR has allowed the accurate identification of low-frequency variant alleles in clinical specimens; however, the multiplex capabilities of droplet digital PCR for variant detection are inadequate. The incorporation of molecular barcodes or unique IDs into next-generation sequencing libraries through PCR has enabled the detection of low-frequency variant alleles across multiple genomic regions. However, rational library preparation and sequencing data analytical strategies that integrate molecular barcodes have rarely been applied to clinical settings. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
February 2019

Alternative definitions of cerebral aneurysm morphological parameters have an impact on rupture risk determination.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Medical University of Silesia, School of Medicine in Katowice, Department of Neurosurgery, Katowice, Poland.

Background: A discrepancy between definitions of morphologic parameters describing cerebral aneurysms across studies leads to conflicting results concerning performances of these factors and threshold values for rupture status prediction. The aim of the study was to evaluate how various definitions of morphologic parameters may influence the prediction of the risk for aneurysm rupture.

Material And Methods: A total of 425 intracranial aneurysms were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.283DOI Listing
February 2019

Pediatric Intracranial Aneurysms: Favorable Outcomes despite Rareness and Complexity.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Pediatric intracranial aneurysms (IAs) are rare and differ from their adult counterparts in terms of their aneurysmal characteristics, presentation, treatment, and outcomes. Their treatment is often more difficult and complex compared to adults. However, studies outlining the clinical impact of pediatric IAs remain sparse. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.280DOI Listing
February 2019

Dysphagia prevention in anterior cervical discectomy surgery.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Neurosurgical Clinic, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, School of Medicine, Palermo, Italy.

Background: Dysphagia is a common complication after anterior cervical discectomy surgery (ACDS). Recent studies have shown that reducing the endotracheal tube cuff pressure (ETCP), local irrigation with methylprednisolone, and minimizing the pharynx/esophagus retraction can decrease the incidence of post-operative dysphagia following ACDS. This is the first study assessing the efficacy of all these three measures simultaneously. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.273DOI Listing
February 2019

Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability of airway inflammation.

Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.011DOI Listing
February 2019

Transthoracic sonographic assessment of B-line scores during ascent to altitude among healthy trekkers.

Respir Physiol Neurobiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

Portable sonography-determined B-lines can indicate pulmonary interstitial edema. We sought to determine the incidence of subclinical pulmonary edema measured by sonographic B-lines among lowland trekkers ascending to high altitude in the Nepal Himalaya. Twenty healthy trekkers underwent portable sonographic examinations and arterial blood draws during ascent to 5160 m over ten days. Read More

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http://dx.doi.org/10.1016/j.resp.2019.02.005DOI Listing
February 2019

Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing.

Nanomedicine 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address:

A nanotube assisted microwave electroporation (NAME) technique is demonstrated for delivering molecular biosensors into viable bacteria for multiplex single cell pathogen identification to advance rapid diagnostics in clinical microbiology. Due to the small volume of a bacterial cell (~femtoliter), the intracellular concentration of the target molecule is high, which results in a strong signal for single cell detection without amplification. The NAME procedure can be completed in as little as 30minutes and can achieve over 90% transformation efficiency. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.015DOI Listing
February 2019

Prevalence of antibodies to lung self-antigens (Kα1 tubulin and collagen V) and donor specific antibodies to HLA in lung transplant recipients and implications for lung transplant outcomes: Single center experience.

Transpl Immunol 2019 Feb 19. Epub 2019 Feb 19.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Purpose: For patients with end stage lung disease, lung transplantation (LT) remains the only definitive treatment option. Long term survival post LT is limited by acute and chronic allograft dysfunction. Antibodies to lung self-antigens Kα1Tubulin and collagen V (autoantibodies) have been implicated in adverse outcomes post LT. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.006DOI Listing
February 2019

Multicenter clinical experience of real life Dalbavancin use in gram-positive infections.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address:

Dalbavancin, a lipoglycopeptide with prolonged half-life approved for the treatment of acute bacterial skin-and-soft-tissue-infections, can be used for the treatment of infections caused by gram-positive bacteria requiring long term treatment such as endocarditis, prosthetic joint infections (PJI) or osteomyelitis. Clinical data is limited in these settings.

Objectives: To evaluate indications, safety, tolerability and long-term outcomes of dalbavancin-treated patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.013DOI Listing
February 2019

The Stability of Treatment Preferences among Patients with Advanced Cancer.

J Pain Symptom Manage 2019 Feb 19. Epub 2019 Feb 19.

Cornell Center for Research on End-of-Life Care, Weill Cornell Medicine, New York, New York, U.S.A.; Division of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, U.S.A.. Electronic address:

Context: Stability of patients' treatment preferences has important implications for decisions about concurrent and future treatment.

Objectives: To examine the stability of treatment preferences and correlates among patients with advanced cancer.

Methods: In this cohort, 104 patients with metastatic cancer, progression after at least one chemotherapy regimen and an oncologist-estimated life-expectancy of ≤ six months participated in structured interviews following clinical visits in which patients' recent scans were discussed. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.01.016DOI Listing
February 2019

AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION FOR TREATMENT-REFRACTORY RELAPSING MULTIPLE SCLEROSIS: POSITION STATEMENT FROM THE AMERICAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Multiple sclerosis (MS) is a chronic, disabling, immune-mediated, central nervous system demyelinating and degenerative disease. Approved disease modifying therapies may be incompletely effective in some patients with highly active relapsing disease and high risk of disability. Immunoablative or myeloablative therapy followed by autologous hematopoietic cell transplantation (AHCT) has been investigated in retrospective studies, clinical trials, and meta-analyses/systematic reviews as an approach to address this unmet clinical need. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.014DOI Listing
February 2019

Risk factors and predictive scoring system for post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan. Electronic address:

We analyzed data of 64,539 consecutive patients in the national Japanese transplant registry, including 40,195 after allogeneic stem cell transplantation, 24,215 after autologous stem cell transplantation, and 129 after syngeneic stem cell transplantation, and 299 developed Epstein-Barr virus positive post-transplant lymphoproliferative disorder. The probability at 2 years was 0.79% after allogeneic transplantation, 0. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.016DOI Listing
February 2019

Accuracy and usability of single-lead ECG from smartphones - A clinical study.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The objective was to evaluate the accuracy, usability and diagnostic capabilities of smartphone ECG (spECG) in both patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.006DOI Listing
February 2019

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Shipping warehouse No. 5, Beijing, 100700, China. Electronic address:

The role of gut microbiota in the management of diabetes has been shown. Several current trials are investigating the effect of probiotics and prebiotics, which are widely used to modulate intestinal microbiota, on inflammatory factors and biomarkers of oxidative stress in diabetic patients; however, their findings are controversial. The aim of the current meta-analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high-sensitivity C-reactive protein (hs-CRP) and biomarkers of oxidative stress in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.016DOI Listing
February 2019

The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Sciences, North Carolina State College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

Causative mutations for familial dilated cardiomyopathy (DCM) have been identified in the phospholamban gene. There are many poorly understood aspects about familial DCM (variable penetrance, expression) which may be studied in natural animal models. We characterized genetic aspects of familial DCM in a canine model with a high incidence of sudden death. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.022DOI Listing
February 2019

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia. Electronic address:

Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic factors in patients with ESCC. Expression at both the mRNA and protein levels was investigated using real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.033DOI Listing
February 2019

Tumor PD-L1 expression in malignant pleural and peritoneal mesothelioma by Dako PD-L1 22C3 pharmDx and Dako PD-L1 28-8 pharmDx assays.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112; ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT, 84108.

Malignant mesothelioma (MM) is an aggressive neoplasm with poor prognosis. The Dako PD-L1 22C3 and 28-8 pharmDx assays are approved by the US Food and Drug Administration (FDA) as companion and complementary diagnostics for the anti-PD-1 drugs pembrolizumab and nivolumab, respectively. Data from multiple clinical trials indicate that immunotherapy has anti-tumor activity in advanced malignant pleural (MPM) and peritoneal mesothelioma (MPeM). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.001DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Combination treatment of preoperative embryo cryopreservation and endoscopic surgery (surgery-ART hybrid therapy) in infertile women with diminished ovarian reserve and uterine myomas or ovarian endometriomas.

J Minim Invasive Gynecol 2019 Feb 19. Epub 2019 Feb 19.

From the Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, (Drs. Kuroda, Nakagawa, and Sugiyama) Tokyo, Japan.

Study Objective: To analyze the clinical outcomes and predictive factors for the therapeutic effect of combination treatment of preoperative embryo cryopreservation and endoscopic surgery ('surgery-assisted reproductive technology [ART] hybrid therapy') in infertile women with diminished ovarian reserve (DOR) with uterine fibroids and/or ovarian endometriomas.

Design: A retrospective cohort study (Canadian Task Force Classification II-2) SETTING: Data from all patients who underwent surgery-ART hybrid therapy at Juntendo University Hospital and Sugiyama Clinic from 2014 to 2016 were analyzed retrospectively. We compared women who experienced livebirth (success group) and implantation failure or miscarriage (failure group) after surgery-ART hybrid therapy and evaluate the predictive factors for livebirth. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.008DOI Listing
February 2019

Biomaterializing the promise of cardiac tissue engineering.

Biotechnol Adv 2019 Feb 19. Epub 2019 Feb 19.

Division of Cardiology, Department of Medicine, Duke University Health System, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address:

During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.009DOI Listing
February 2019

An update on the controversy around offering oral immunotherapy to peanut-allergic children outside of research.

Ann Allergy Asthma Immunol 2019 Feb 19. Epub 2019 Feb 19.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.anai.2019.02.011DOI Listing
February 2019

Propagermanium, a CCR2 inhibitor, attenuates cerebral ischemia/reperfusion injury through inhibiting inflammatory response induced by microglia.

Neurochem Int 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China. Electronic address:

CCR2 could recruit immune cells migrating into brain after ischemic stroke. It is unclear whether and why Propagermanium (PG, a CCR2 inhibitor) is able to protect against ischemic injury. Middle cerebral artery occlusion (MCAO) and reperfusion injury in C57BL/6 J male mice were performed in vivo to mimic ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.02.010DOI Listing
February 2019

Reply to Rzymski and Klimaszyk regarding comment on "Mushroom poisoning: a proposed new clinical classification.

Toxicon 2019 Feb 19. Epub 2019 Feb 19.

Dept. for Clinical Toxicology at II, Med. Klinik, TU, München, Munich, Germany.

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http://dx.doi.org/10.1016/j.toxicon.2019.02.007DOI Listing
February 2019

Psychopathology and extrapyramidal side effects in smoking and non-smoking patients with schizophrenia: Systematic review and meta-analysis of comparative studies.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address:

The association between smoking and psychopathology and extrapyramidal symptoms in schizophrenia has been controversial. This systematic review and meta-analysis compared psychopathology and extrapyramidal symptoms between smoking and non-smoking schizophrenia patients. The PubMed, EMBASE, PsycINFO, Cochrane Library, and Web of Science databases were independently and systematically searched by two researchers to identify relevant articles. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.011DOI Listing
February 2019

Trainee Contribution Is Not Associated With Citation Frequency: A Retrospective Study.

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Assistant Professor, Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA.

Purpose: Publication citation frequency is a measure of scientific influence. The purpose of this study was to measure the association between trainee involvement in publications and citation frequency.

Materials And Methods: A retrospective cohort study of the Journal of Oral and Maxillofacial Surgery from January to December 2010 was conducted. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.022DOI Listing
January 2019

Intrinsic Bone Defects in Cystinotic Mice.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Bone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

Cystinosis is a rare lysosomal storage disorder caused by loss of function mutations of the CTNS gene, encoding cystinosin, a symporter that mediates cystine efflux from lysosomes. About 95% of patients with cystinosis display renal Fanconi syndrome, short stature, osteopenia, and rickets . In this study, we investigated whether the absence of cystinosin primarily affects bone remodeling activity, apart from the influences of the Fanconi syndrome on bone mineral metabolism. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.015DOI Listing
February 2019

Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chem Biol Interact 2019 Feb 19. Epub 2019 Feb 19.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06521, USA. Electronic address:

Glutathione (GSH), the most abundant cellular non-protein thiol, plays a pivotal role in hepatic defense mechanisms against oxidative damage. Despite a strong association between disrupted GSH homeostasis and liver diseases of various etiologies, it was shown that GSH-deficient glutamate-cysteine ligase modifier subunit (Gclm)-null mice are protected against fatty liver development induced by a variety of dietary and environmental insults. The biochemical mechanisms underpinning this protective phenotype have not been clearly defined. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.015DOI Listing
February 2019

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell 2019 Feb;176(5):1143-1157.e13

Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address:

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.044DOI Listing
February 2019

Advancing the Care of Severe Asthma: Differential Diagnosis, Multidisciplinary Management, and Patient Engagement.

Am J Med 2019 Feb 19. Epub 2019 Feb 19.

Adjunct Professor, Department of Family and Community Health, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.amjmed.2019.02.002DOI Listing
February 2019

Acute Corticosterone Treatment Elicits Antidepressant-like Actions on the Hippocampal 5-HT and the Immobility Phenotype.

Brain Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, China. Electronic address:

Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions. However, CORT-elicited changes in the hippocampal 5-HT transmission and the immobility phenotype had not been fully addressed. The current study sought to explore effects of acute CORT subcutaneously injected at 10, 20, 40 mg/kg on the extracellular 5-HT in the hippocampus and the immobility time in male CD-1 mice. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.022DOI Listing
February 2019

Real-world misuse, abuse, and dependence of abuse deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.

Postgrad Med 2019 Feb 22. Epub 2019 Feb 22.

h Pfizer Inc - Medical Affairs.

Objective: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients.

Methods: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from January 1, 2015, to June 30, 2016. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585688DOI Listing
February 2019

Inclusion in the clinical learning environment: Building the conditions for diverse human flourishing.

Med Teach 2019 Feb 22:1-5. Epub 2019 Feb 22.

b Department of Field Activities , Accreditation Council for Graduate Medical Education , Chicago , IL.

Aim: While diversity, equity, and inclusion are much proclaimed aspirational goals in education programs, the clinical learning environment (CLE) frequently falls short of meaningful incorporation of these concepts in processes, policies, and local culture. In this paper, we explore how inclusion, diversity, and equity can and should be defined and operationalized within medical education.

Methods: Three cases, organized around Hafferty's curricular framework (formal, informal, and hidden), we illustrate lapses and potential best practices in inclusion in the CLE. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1566600DOI Listing
February 2019

AMEE guide no. 123 - How to read studies of educational costs.

Med Teach 2019 Feb 22:1-8. Epub 2019 Feb 22.

j BMJ Learning and Quality , London , United Kingdom of Great Britain and Northern Ireland.

Healthcare and health professions education share many of the same problems in decision making. In both cases, there is a finite amount of resources, and so choices need to be made between alternatives. To navigate the options available requires effective decision making. Read More

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http://dx.doi.org/10.1080/0142159X.2018.1552784DOI Listing
February 2019

Recurrence of depression in the perinatal period: Clinical features and associated vulnerability markers in an observational cohort.

PLoS One 2019 22;14(2):e0212964. Epub 2019 Feb 22.

The Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: Antidepressant medication is commonly used for the prevention of depression recurrence in the perinatal period, yet it is unknown what vulnerability markers may play a role in recurrence. The objective of the current study was to provide a descriptive overview of the associated characteristics of women who experienced a perinatal recurrence of depression despite ongoing antidepressant use, and further, to identify clinically measurable vulnerability markers associated with recurrence.

Methods: Eighty-five pregnant women with a history of depression who used antidepressants (e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212964PLOS
February 2019

Association between circulating mononuclear cell mitochondrial DNA copy number and in-hospital mortality in septic patients: A prospective observational study based on the Sepsis-3 definition.

PLoS One 2019 22;14(2):e0212808. Epub 2019 Feb 22.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province; The Third Grade Laboratory under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China.

Purpose: To explore the association between circulating mononuclear cell mitochondrial DNA copy number and the prognosis of sepsis patients based on the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3 definition).

Methods: A total of 200 adult patients who had recently devoloped sepsis were prospectively recruited as the study cohort. Demographic and clinical data were recorded along with a 28-day outcome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212808PLOS
February 2019

Omentin protects H9c2 cells against docetaxel cardiotoxicity.

PLoS One 2019 22;14(2):e0212782. Epub 2019 Feb 22.

Cardiology Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela and Health Research Institute, University Clinical Hospital of Santiago de Compostela-Santiago de Compostela, Spain.

Background: Association between obesity and cardiovascular diseases is well known, however increased susceptibility of obese patients to develop several cancer types is not so commonly known. Current data suggest that poorer overall survival in cancer patients might be associated to non-cancer-related causes such as higher risk of cardiotoxicity in obese patients treated with chemotherapeutic agents. Omentin, a novel adipokine decreased in obesity, is actually in the spotlight due to its favourable effects on inflammation, glucose homeostasis and cardiovascular diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212782PLOS
February 2019

PCR with electrospray ionization-mass spectrometry on bronchoalveolar lavage for detection of invasive mold infections in hematological patients.

PLoS One 2019 22;14(2):e0212812. Epub 2019 Feb 22.

Department of Infectious Diseases, Karolinska University Hospital, Huddinge, Sweden.

Invasive mold infections are life-threatening complications in patients with hematological malignancies. Conventional microbiological methods for diagnosing invasive pulmonary mold infections have low sensitivity, and molecular methods are being developed. Detection of molds using PCR with a narrow spectrum has been reported, but data with broad-spectrum PCR are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212812PLOS
February 2019

Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship.

PLoS One 2019 22;14(2):e0212661. Epub 2019 Feb 22.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover targets for stewardship.

Methods: An Institution-based prospective observational study was performed from 9 April to 7 July 2014 in the internal medicine wards of Tikur Anbessa Specialized Hospital. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212661PLOS
February 2019

Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data.

PLoS One 2019 22;14(2):e0212665. Epub 2019 Feb 22.

Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

Background: Rapid antibiotic administration is known to improve sepsis outcomes, however early diagnosis remains challenging due to complex presentation. Our objective was to develop a model using readily available electronic health record (EHR) data capable of recognizing infant sepsis at least 4 hours prior to clinical recognition.

Methods And Findings: We performed a retrospective case control study of infants hospitalized ≥48 hours in the Neonatal Intensive Care Unit (NICU) at the Children's Hospital of Philadelphia between September 2014 and November 2017 who received at least one sepsis evaluation before 12 months of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212665PLOS
February 2019

The analysis of causal relationships between blood lipid levels and BMD.

PLoS One 2019 22;14(2):e0212464. Epub 2019 Feb 22.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Bone mineral density (BMD) and lipid levels are two of the most extensively studied risk factors for common diseases of aging, such as cardiovascular disease (CVD) and osteoporosis (OP). These two risk factors are also correlated with each other, but little is known about the molecular mechanisms behind this correlation. Recent studies revealed that circulating levels of several metabolites involved in the biosynthesis of androsterone correlate significantly with BMD and have the capacity to affect cholesterol and lipids levels. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212464PLOS
February 2019

HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers.

PLoS One 2019 22;14(2):e0212559. Epub 2019 Feb 22.

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.

Aim: Deletions are observed frequently in the preS1/S2 region of hepatitis B virus (HBV) genome, in association with liver disease advancement. However, the most significant preS1/S2 region and its influences on viral markers are unclear.

Methods: The preS1/S2 HBV regions of 90 patients without antiviral therapy were subjected to deep sequencing and deleted regions influencing viral markers were investigated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212559PLOS
February 2019

Simplified end stage renal failure risk prediction model for the low-risk general population with chronic kidney disease.

PLoS One 2019 22;14(2):e0212590. Epub 2019 Feb 22.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Background: Chronic kidney disease (CKD) contributes significant morbidity and mortality among Asians; hence interventions should focus on those most at-risk of progression. However, current end stage renal failure (ESRF) risk stratification tools are complex and not validated in multi-ethnic Asians. We hence aimed to develop an ESRF risk prediction model by taking into account ethnic differences within a fairly homogenous socioeconomic setting and using parameters readily accessible to primary care clinicians managing the vast majority of patients with CKD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212590PLOS
February 2019

Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed.

PLoS One 2019 22;14(2):e0212544. Epub 2019 Feb 22.

Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, United States of America.

Two hip quality phenotypes-a hip-extended score assigned by a board certified radiologist and the PennHIP distraction index-were analyzed to estimate genetic parameters and to calculate estimated breeding values used for selecting replacement breeders. Radiographs obtained at 12-18 months of age were available on 5,201 German Shepherd Dogs, 4,987 Labrador Retrievers and 2,308 Golden Retrievers. Obtained by fitting a two-trait model using Bayesian techniques, estimates of heritability for the hip-extended score were 0. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212544PLOS
February 2019

A management system for randomized clinical trials: A novel way to supply medication.

PLoS One 2019 22;14(2):e0212475. Epub 2019 Feb 22.

Department of Preventive & Predictive Medicine, Epidemiology Unit, Foundation IRCCS National Cancer Institute of Milan, Milan, Italy.

Background: Randomized controlled clinical trials require management effort, involving huge organizational, economic and informatics investments. Information technology offers opportunities to approach clinical trial methodology in new ways. However, there are only a few reports of computerized data and drug management systems. Read More

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February 2019

B cell subset distribution in human bone marrow is stable and similar in left and right femur: An instructive case.

PLoS One 2019 22;14(2):e0212525. Epub 2019 Feb 22.

Charité Universitätsmedizin Berlin, Department of Medicine/Rheumatology and Clinical Immunology, Berlin, Germany.

The bone marrow (BM) is, in addition to being the site of B cell development, a tissue that harbors long-lived plasma cells (PC), the cells that protect the body against foreign antigens by continuous production of antibodies. Nothing is known about the long-term stability and functionality of both B cells and PC in the BM at the individual donor level since repeated sampling possibilities outside of oncology are scarce. Here, we had the opportunity to obtain BM samples from a patient undergoing bilateral total hip arthroplasty half a year apart. Read More

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February 2019
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