1,345,418 results match your criteria Clinical Medicine & Research [Journal]


Contribution of Palmar Radiocarpal and Ulnocarpal Ligaments to the Stability of the Canine Antebrachiocarpal Joint.

Vet Comp Orthop Traumatol 2019 Apr 18. Epub 2019 Apr 18.

The Laboratory of Biomechanics, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Objective:  The aim of this study was to evaluate the contribution of the palmar radiocarpal ligament and the palmar ulnocarpal ligament to canine antebrachiocarpal joint stability.

Materials And Methods:  The right carpus of four dog cadavers, free of musculoskeletal pathology, was stripped of muscle. Each specimen was placed into a custom-made joint testing machine and tested at 15° extension, and 0° and 15° flexion. Read More

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http://dx.doi.org/10.1055/s-0039-1685208DOI Listing

Feasibility of transabdominal Doppler ultrasonography for studying ovarian blood flow characteristics in cycling gilts.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):77-85. Epub 2019 Apr 18.

Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig.

Objective: The aim of this study was to assess ovarian blood flow characteristics by applying transabdominal color Doppler ultrasonography during the course of the estrous cycle in gilts.

Materials And Methods: Estrus and ovulation were synchronized in 15 pubertal gilts. During their consecutive spontaneous estrous cycle the gilts were sonographically scanned daily and ovarian blood flow was determined by imaging perfused areas of the ovarian hilus and the ovarian tissue. Read More

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http://dx.doi.org/10.1055/a-0858-0076DOI Listing

Corneal Endothelial Decompensation after Ocular Chemical Burn: Description of a New Finding.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):371-376. Epub 2019 Apr 18.

Augenklinik, Universitatsspital Basel, Basel, Switzerland.

Background: Ocular chemical burn is an ophthalmological emergency. Therefore, chemical injuries should be promptly addressed in order to initiate the appropriate treatment as soon as possible and optimize the visual prognosis. We present a retrospective study of ten cases with ocular chemical burn including one with superglue and one with a liquid plaster material injury and describe their clinical course. Read More

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http://dx.doi.org/10.1055/a-0857-6538DOI Listing

Encephalopathy in neonates with subgaleal hemorrhage is a key predictor of outcome.

Pediatr Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Objective: Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clinical encephalopathy to short-term outcomes in neonates with SGH. Read More

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http://dx.doi.org/10.1038/s41390-019-0400-1DOI Listing

Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

Y Park, Internal medicine, Seoul National University College of Medicine, Seoul, Korea (the Republic of).

Synergistic effects of BRAFV600E and TERT promoter mutations on the poor clinical outcomes in papillary thyroid cancer (PTC) have been demonstrated. The potential mechanism of this phenomenon has been proposed: MAPK pathway activation by the BRAFV600E mutation may upregulate E-twenty six (ETS) transcription factors, increasing TERT expression by binding to the ETS-binding site generated by the TERT promoter mutation; however, it has not yet been fully proven. This article provides transcriptomic insights into the interaction between BRAFV600E and TERT promoter mutations mediated by ETS factors in PTC. Read More

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http://dx.doi.org/10.1530/ERC-17-0562DOI Listing

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
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Intraoperative ultrasonography (ioUS) characteristics of focal cortical dysplasia (FCD) type II b.

Seizure 2019 Mar 12;69:80-86. Epub 2019 Mar 12.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, USA.

Purpose: Focal cortical dysplasia (FCD) is one of the major causes of drug-resistant epilepsy. Surgery has proved to be the treatment of choice, however up to a third of patients experience only partial resection. Ill-defined borders and lesions embedded in eloquent areas are two of the main drawbacks of FCD surgery. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.020DOI Listing

More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

J Clin Virol 2019 Apr 7;116:11-17. Epub 2019 Apr 7.

Department of Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives: Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study Design: A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.04.003DOI Listing

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing

Protective effects of tribulus terrestris extract and angiotensin blockers on testis steroidogenesis in copper overloaded rats.

Ecotoxicol Environ Saf 2019 Apr 15;178:113-122. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Sharkia Gov., Egypt. Electronic address:

The rational of the current study was to assess whether Tribulus terrestris extract (TTE) could alleviate long-term copper (Cu) overload-induced testicular dysfunction compared to enalapril and losartan. Rats were administered either vehicle (control group, n = 10) or copper sulfate pentahydrate (CuSO·5HO, 200 mg/kg, p.o) for 90 days (n = 40). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.012DOI Listing

Trauma-Focused Cognitive Behavioral Therapy for Childhood Traumatic Separation.

Child Abuse Negl 2019 Apr 15;92:179-195. Epub 2019 Apr 15.

Department of Psychiatry, Allegheny General Hospital, Allegheny Health Network, Drexel University College of Medicine, 4 Allegheny Center, 8th Floor, Pittsburgh, PA 15212, USA. Electronic address:

Objectives: In light of the current U.S. family separation crisis, there is growing attention to Childhood Traumatic Separation, defined here as a significant traumatic stress reaction to a familial separation that the child experiences as traumatic. Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.03.006DOI Listing

EEG changes in patients on antipsychotic therapy: A systematic review.

Epilepsy Behav 2019 Apr 15;95:1-9. Epub 2019 Apr 15.

Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: The objective of the study was to characterize the electroencephalogram (EEG) changes associated with different antipsychotic medications based on the evidence from the literature.

Methods: A systematic search of the databases Medline, PsycINFO, and PubMed was conducted. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this systematic review. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.005DOI Listing

The biographical gaze: Psychotherapeutic practice in psychosomatic hospitals in Germany.

Authors:
Sabine Flick

Soc Sci Med 2019 Mar 28;230:83-90. Epub 2019 Mar 28.

Goethe-Universität Frankfurt a.M. Institut für Soziologie, Theodor-W.-Adorno-Platz 6, 60323, Frankfurt, Germany. Electronic address:

This article introduces the concept of a "biographical gaze" based on two dimensions: On one hand, I draw on findings from my qualitative empirical research on psychotherapists' practice and their interpretation of patients' suffering. The case study was conducted in psychosomatic hospitals in Germany and focused on psychotherapists based on different kinds of data (supervision transcripts, interviews, medical records, and questionnaires). On the other hand, I connect this research with theories on the clinical gaze, as well as Bourdieu's critique of the "biographical illusion. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.03.037DOI Listing

A SCA7 premutation may be a novel Mendelian modifier of MS course: A case report.

Mult Scler Relat Disord 2019 Apr 13;31:148-150. Epub 2019 Apr 13.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

A proportion of patients with the phenotype of complex genetic disorders carry dominantly inherited Mendelian traits, exemplified by hereditary spastic paraparesis influencing pyramidal symptoms in some MS cases. We here describe a mutable ATXN7 gene, a SCA7 premutation, in a patient fulfilling contemporary definitions of primary progressive MS. His onset age, and onset with a severely progressive cerebellar ataxia syndrome, was outside the reported range of symptoms in a representative MS material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193016
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http://dx.doi.org/10.1016/j.msard.2019.04.009DOI Listing
April 2019
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Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.

Environ Int 2019 Apr 15;127:720-729. Epub 2019 Apr 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States of America. Electronic address:

Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd worsened inflammation in response to sub-lethal H1N1 infection. Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.054DOI Listing

Formulation, clinical and histopathological assessment of microemulsion based hydrogel for UV protection of skin.

Colloids Surf B Biointerfaces 2019 Apr 8;179:393-404. Epub 2019 Apr 8.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91388-13944, Islamic Republic of Iran.

The aim of this study was to prepare a microemulsion based hydrogel containing sesame oil and evaluate its topical application in preventing the harmful effects of UV radiation on the guinea pig's skin using histopathologic and clinical findings. Sesame oil with high antioxidant content and unique chemical and physiological properties is a suitable candidate for the evolution of UV protection on skin. Applying this natural oil in microemulsion formulation containing particles with nanometer size can enhance its efficacy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.015DOI Listing

Evaluation of the lung immune prognostic index for prediction of survival and response in patients treated with atezolizumab for non-small cell lung cancer: pooled analysis of clinical trials.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

College of Medicine and Public Health, Flinders University, Adelaide SA 5042 Australia.

Introduction: There is substantial variability in survival and response outcomes for patients using immune checkpoint inhibitors (ICIs), and predictive markers are required to guide treatment decisions. A lung immune prognostic index (LIPI) was recently developed to predict ICI treatment outcomes and we aim to evaluate whether LIPI is predictive of survival and response for patients treated with atezolizumab for advanced non-small cell lung cancer (NSCLC).

Methods: Pooled analysis of patient-level data of four clinical trials of atezolizumab for NSCLC. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.006DOI Listing

Multicenter evaluation of a novel ROS1 immunohistochemistry assay (SP384) for detection of ROS1 rearrangements in a large cohort of lung adenocarcinoma patients.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Université Côte d'Azur, University Hospital Federation OncoAge, Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France;; Université Côte d'Azur, CNRS, INSERM, Institute of Research on Cancer and Ageing of Nice (IRCAN), University Hospital Federation OncoAge, Nice, France;; Université Côte d'Azur, University Hospital Federation OncoAge, Hospital-Related Biobank (BB-0033-00025), Pasteur Hospital, Nice, France;. Electronic address:

Introduction: The detection of a ROS1 rearrangement in advanced and metastatic lung adenocarcinoma (LUAD) lead to a targeted treatment with tyrosine kinase inhibitors, with favorable progression-free survival and overall survival of the patients. Thus, it is mandatory to screen for the ROS1 rearrangement in all these patients. ROS1 rearrangements can be detected using break-apart fluorescence in situ hybridization (FISH), which is the "gold standard"; however, ROS1 immunohistochemistry (IHC) can be used as a screening test since it is widely available, easy and rapid to perform, and cost-effective. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.03.024DOI Listing

Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations.

J Affect Disord 2019 Apr 9;252:350-357. Epub 2019 Apr 9.

Research and Knowledge Center, The Danish Veteran Center, Garnisonen 1, 4100 Ringsted, Denmark.

Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder that occurs with relatively high frequency after deployment to warzones (∼10%). While twin studies have estimated the heritability to be up to 40%, thus indicating a considerable genetic component in the etiology, the biological mechanisms underlying risk and development of PTSD remain unknown.

Methods: Here, we conduct a genome-wide association study (GWAS; N = 2,481) to identify genome regions that associate with PTSD in a highly homogenous, trauma-exposed sample of Danish soldiers deployed to war and conflict zones. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.070DOI Listing

The effect of adjunctive nutraceuticals in bipolar disorder: A systematic review of randomized placebo-controlled trials.

J Affect Disord 2019 Apr 8;252:334-349. Epub 2019 Apr 8.

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Italy; U.O.C. Clinica Psichiatrica, A.O.U. Policlinico-Vittorio Emanuele, Presidio "G. Rodolico", Catania, Italy.

Background: Nutraceuticals are a group of compounds of growing interest for mental health professionals. Given the implication of certain nutrients in the onset of bipolar disorder, it has been hypothesized that nutraceuticals might be effective in improving symptoms of the condition (i.e. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.039DOI Listing

Perioperative management of a patient with severe factor V deficiency presenting with chronic subdural hematoma: a clinical report.

World Neurosurg 2019 Apr 15. Epub 2019 Apr 15.

Department of Anaesthesiology University Hospital of Munich (LMU) Marchioninistraße 15 81377 Munich Germany.

Background: Severe factor V deficiency is an extremely rare coagulation disorder. Patients with factor V activity below 5% usually become symptomatic in early childhood.

Methods: We report the case of an 82 year old woman with incidentally diagnosed severe factor V deficiency, who developed a symptomatic chronic subdural hematoma, requiring burr-hole craniostomy. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.080DOI Listing

Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis.

Arch Oral Biol 2019 Apr 9;102:113-121. Epub 2019 Apr 9.

Department of Periodontology, School of Dentistry, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: The aim of this systematic review was to evaluate the existing evidence on the association between Thalassemia major (TM) and periodontal condition.

Materials & Methods: MEDLINE via OVID, EMBASE, and The Cochrane Database (including the Central Register of Controlled Trials (CENTER)), were searched up to September 2018 to identify observational studies eligible for systematic review and meta-analyses. Newcastle-Ottawa Scale (NOS) was used for quality assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183090
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http://dx.doi.org/10.1016/j.archoralbio.2019.04.004DOI Listing
April 2019
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Analysing training in gender-based violence for undergraduate nursing students in Spain: A mixed-methods study.

Nurse Educ Today 2019 Feb 12;77:71-76. Epub 2019 Feb 12.

Unit of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE-90187 Umea, Sweden. Electronic address:

Background: Health-care professionals, and nurses especially among them, play an essential role in the health sector's response to gender-based violence. To be able to successfully address this major public health issue they need specific training in the topic.

Objective: To analyse training on gender-based violence that nursing students receive at universities in Spain. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.017DOI Listing
February 2019

A text message delivered smoking cessation intervention: Design and rationale of the Text My Quit Study.

Contemp Clin Trials 2019 Apr 15. Epub 2019 Apr 15.

Live Inspired LLC, Washington, DC, United States.

Introduction: Smoking cessation interventions delivered through mobile technologies offer promise as an effective intervention tool. However, most existing programs have not been empirically tested, were not developed with end-user participation, and/or do not address evidence-based cognitive and behavioral variables shown to enhance smoking cessation in clinical trials. In addition, many programs tested in research trials have required users to access the internet and/or a smartphone app to access all program features, limiting the potential reach of those programs. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.010DOI Listing

Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial.

Contemp Clin Trials 2019 Apr 15. Epub 2019 Apr 15.

National Center for PTSD, Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Posttraumatic stress disorder (PTSD) is a debilitating disorder with limited medication treatment options. Recent reports have described the dearth of research on new drug development as a crisis in the pharmacotherapy of PTSD. There are only two PTSD medications approved by the U. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.009DOI Listing

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:

The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition rates for human immunodeficiency virus (HIV) among Sub-Saharan African women. Currently, the lead candidate microbicide is a 28-day silicone elastomer vaginal ring releasing dapivirine (Ring-004), an experimental non-nucleoside reverse transcriptase inhibitor. The ring was tested in two pivotal Phase III clinical studies in 2016 and is currently undergoing review by the European Medicines Agency. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.040DOI Listing

Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Fractional CO laser treatment has been used in some clinical trials to promote topical drug delivery. Currently, there is no standard for laser settings to achieve a feasible therapy. The cutaneous recovery following laser treatment and its influence on drug absorption have not been well explored. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.043DOI Listing

Adverse and hormetic effects in rats exposed for 12 months to low dose mixture of 13 chemicals: RLRS part III.

Toxicol Lett 2019 Apr 15. Epub 2019 Apr 15.

Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, Moscow 119991, Russian Federation. Electronic address:

The aim of the current study was to evaluate the effects of a mixture of thirteen common chemicals on rats, after a one-year exposure to doses around the acceptable daily intake (ADIs), using blood and urinary tests. The influence of low doses of the mixture on weight gain, water consumption, feed consumption and feed efficiency, biochemistry parameters, haematological parameters, blood lymphocytes subsets, serum inflammation profile and urine parameters was evaluated. Our mixture caused a moderate monotonic increase of the males' appetite and a non-monotonic increase of anabolism and a monotonic increase of appetite for the females. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.04.005DOI Listing

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing

Conjugal transfer of PMQR from uropathogenic E.coli under high ciprofloxacin selection pressure generates gyrA mutation.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, India. Electronic address:

Incidence of high fluoroquinolone resistance has been rising rapidly worldwide. Resistance against fluoroquinolones can be either chromosomal or plasmid mediated. Plasmid mediated quinolone resistant(PMQR) genes impart low level of resistance against fluoroquinolones but provides favorable background for selection of additional chromosomally encoded resistance mechanisms. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.021DOI Listing

L. pseudomesenteroides and L. johnsonii isolated from yaks in Tibet modulate gut microbiota in mice to ameliorate enteroinvasive Escherichia coli-induced diarrhea.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

College of Animals Husbandry and Veterinary Medicine, Tibet Agriculture and Animal Husbandry University, Linzhi, Tibet, 860000, PR China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China. Electronic address:

Enteroinvasive Escherichia coli (EIEC) are well-known food-borne pathogens that cause animal intestinal diseases. Lactobacillus is believed to inhibit intestinal pathogens and maintain a healthy gut microbiota. This study aimed to investigate the effects of pre-supplementation of Lactobacillus from yaks (4500m) to prevent the clinical symptoms and the improvement of the disordered flora caused by E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193014
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http://dx.doi.org/10.1016/j.micpath.2019.04.020DOI Listing
April 2019
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Canine distemper virus increased the differentiation of CD4CD8 T cells and mRNA expression of inflammatory cytokines in peripheral blood lymphocyte from canine.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, No. 5333 Xi'an Road, Changchun, Jilin 130062, China. Electronic address:

Background: Canine distemper virus (CDV) can cause a highly contagious disease to canid. However, how CDV affects peripheral blood lymphocyte (PBL) remains unclear.

Methods: In this study, CDV infected PBL was cultured to investigate the effect of CDV on the differentiation of lymphocytes and the mRNA expression of inflammatory cytokines in PBL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193009
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http://dx.doi.org/10.1016/j.micpath.2019.04.025DOI Listing
April 2019
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Sex-Specific Neurogenic Deficits and Neurocognitive Disorders in Middle-Aged HIV-1 Tg26 Transgenic Mice.

Brain Behav Immun 2019 Apr 15. Epub 2019 Apr 15.

Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States. Electronic address:

Varying degrees of cognitive deficits affect over half of all HIV-1 infected patients. Because of antiretroviral treatment (ART) regimens, the HIV-1 patient population is increasing in age. Very few epidemiological studies have focused on sex-specific differences in HIV-1-associated neurocognitive disorders (HAND). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183060
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http://dx.doi.org/10.1016/j.bbi.2019.04.029DOI Listing
April 2019
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Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors.

Mol Cell Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Endocrinology - LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Electronic address:

Defining biomarkers for invasive pituitary neuroendocrine tumors (PitNETs) is highly desirable. The high mobility group A (HMGA) proteins are among the most widely expressed cancer-associated proteins. Indeed, their overexpression is a frequent feature of human malignancies, including PitNETs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193011
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http://dx.doi.org/10.1016/j.mce.2019.04.010DOI Listing
April 2019
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Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders A 10-year follow-up study.

Spine J 2019 Apr 15. Epub 2019 Apr 15.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. Electronic address:

Background Context: Dural ectasia is widening of the dural sac often seen in patients with Marfan syndrome and other hereditary connective tissue disorders. Dural ectasia can cause specific symptoms and is associated with surgical complications. The knowledge on how and at which age dural ectasia develops is incomplete. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.04.010DOI Listing

Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Massachusetts General Hospital, Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA. Electronic address:

Background & Aims: Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial-many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inform ongoing debate and policy, we modeled long-term outcomes of early vs delayed liver transplantation for patients with AH.

Methods: We developed a mathematical model to simulate early vs delayed liver transplantation for patients with severe AH and different amounts of alcohol use after transplantation: abstinence, slip (alcohol use followed by sobriety), or sustained use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.012DOI Listing
April 2019
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IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
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Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity.

Authors:
Brian C Weiner

Clin Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Clinical Associate Professor, Medicine, Gastroenterology, Hepatology, Nutrition. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.023DOI Listing

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria. Electronic address:

Epidermolytic ichthyosis (EI) is a skin fragility disorder caused by dominant-negative mutations in KRT1 or KRT10. No definitive restorative therapies exist that target these genetic faults. Gene editing can be used to efficiently introduce frameshift mutations to inactivate mutant genes. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1146DOI Listing

Gluten challenge induces skin and small bowel relapse in long-term gluten-free diet-treated dermatitis herpetiformis.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease causing an itchy, blistering rash. Skin IgA deposits are pathognomonic for DH, and the treatment of choice is a life-long gluten-free diet (GFD). Preliminary evidence suggests that there are DH patients who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing

Clinical Significance of the Esophageal Outflow Resistance Imposed by a Nissen Fundoplication.

J Am Coll Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

Background: Attention has been focused on the amplitude of esophageal body contraction to avoid persistent dysphagia after a Nissen fundoplication. The current recommended level is a contraction amplitude in the distal third of esophagus above the 5th percentile. We hypothesized that a more physiologic approach is to measure outflow resistance imposed by a fundoplication, which needs be overcome by the esophageal contraction amplitude. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.03.024DOI Listing

Lipids: Two sites of the same coin in lung fibrosis.

Cell Signal 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry, Universities of Giessen and Marburg Lung Center, Giessen, Germany. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive extracellular matrix deposition in the lung parenchyma leading to the destruction of lung structure, respiratory failure and premature death. Recent studies revealed that the pathogenesis of IPF is associated with alterations in the synthesis and the activity of lipids, lipid regulating proteins and cell membrane lipid transporters and receptors in different lung cells. Furthermore, deregulated lipid metabolism was found to contribute to the profibrotic phenotypes of lung fibroblasts and alveolar epithelial cells. Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.04.007DOI Listing

Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus (HPV) with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay.

J Virol Methods 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:

Background: Human papillomavirus (HPV) is well established as the main cause of cervical cancer. Non-invasive self-collected urine and vaginal sampling have the potential advantage of increasing patient compliance with cervical cancer screening.

Methods: Self-collected vaginal and urine samples and clinician-collected cervical samples were collected from 101 patients, including 84 patients with high grade squamous intraepithelial lesion and 17 patients with benign ovarian disease. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.012DOI Listing

On the critical evaluation and confirmation of germline sequence variants identified using massively parallel sequencing.

J Biotechnol 2019 Apr 15. Epub 2019 Apr 15.

Institute for Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; Geneton Ltd., Bratislava, Slovakia. Electronic address:

Although massively parallel sequencing (MPS) is becoming common practice in both research and routine clinical care, confirmation requirements of identified DNA variants using alternative methods are still topics of debate. When evaluating variants directly from MPS data, different read depth statistics, together with specialized genotype quality scores are, therefore, of high relevance. Here we report results of our validation study performed in two different ways: 1) confirmation of MPS identified variants using Sanger sequencing; and 2) simultaneous Sanger and MPS analysis of exons of selected genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.013DOI Listing
April 2019
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Blonanserin ameliorates social deficit through dopamine-D receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.

Neurochem Int 2019 Apr 15. Epub 2019 Apr 15.

Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan. Electronic address:

Blonanserin differs from other antipsychotic drugs, such as risperidone and olanzapine and exhibits a higher affinity for dopamine-D receptors than for serotonin 5-HT receptors. We investigated the involvement of dopamine-D receptors in the effect of blonanserin on the social deficit observed in an animal model of schizophrenia and sought to elucidate the molecular mechanism underlying its action. Mice received phencyclidine (PCP: 10 mg/kg/day, s. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.008DOI Listing

Mesenchymal Stem Cells: from Regeneration to Cancer.

Pharmacol Ther 2019 Apr 15. Epub 2019 Apr 15.

The Jackson Laboratory, Bar Harbor, ME 04609, USA. Electronic address:

Mesenchymal stem cells (MSCs) are multipotent tissue stem cells that differentiate into a number of mesodermal tissue types, including osteoblasts, adipocytes, chondrocytes and myofibroblasts. MSCs were originally identified in the bone marrow (BM) of humans and other mammals, but recent studies have shown that they are multilineage progenitors in various adult organs and tissues. MSCs that localize at perivascular sites function to rapidly respond to external stimuli and coordinate with the vascular and immune systems to accomplish the wound healing process. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.04.005DOI Listing

Exploring the bedside clinician's medical intelligence in the age of artificial intelligence.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Paris-Diderot University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.045DOI Listing
April 2019
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Chronic Kidney Disease in Agricultural Communities.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Informatics, The Ohio State University. Electronic address:

Patients residing in agricultural communities have a high risk of developing chronic kidney disease. In the Great Plains, geo-environmental risk factors (variable climate, temperature, air quality, water quality and drought) combine with agro-environmental risk factors (exposure to fertilizers, soil conditioners, herbicides, fungicides and pesticides) to increase risk for toxic nephropathy. However, research defining the specific influence of agricultural chemicals on the progression of kidney disease in rural communities has been somewhat limited. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.03.036DOI Listing

Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.

Clin Biochem 2019 Apr 15. Epub 2019 Apr 15.

Centre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.011DOI Listing

Radiation-Induced Lung Injury: Assessment and Management.

Chest 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX, USA.

Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation therapy (RT) and manifests acutely as radiation pneumonitis (RP) and chronically as radiation pulmonary fibrosis (RPF). Since most patients with thoracic and breast malignancies are expected to undergo RT in their lifetime, many with curative intent, the population at risk is significant. Further, indications for thoracic RT are expanding given the advent of stereotactic body radiation therapy or stereotactic ablative radiotherapy (SBRT/SABR) for early stage lung cancer in non-surgical candidates as well as oligometastatic pulmonary disease from any solid tumor. Read More

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http://dx.doi.org/10.1016/j.chest.2019.03.033DOI Listing
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