65,049 results match your criteria Clinical Lymphoma & Myeloma [Journal]


Combined Surgical Treatment for Chronic Upper Extremity Lymphedema Patients: Simultaneous Lymph Node Transfer and Liposuction.

Ann Plast Surg 2019 Apr 3. Epub 2019 Apr 3.

Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki.

Background: Upper limb lymphedema is a common problem after axillary lymph node dissection. Lymphatic drainage can be improved by microvascular lymph node transfer, whereas liposuction can be used to reduce arm volume and excess of adipose tissue. We present the results of chronic lymphedema patients who have undergone lymph node transfer and liposuction simultaneously in 1 operation and compare the results with patients who have undergone lymph node transfer without liposuction. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001828DOI Listing

Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings.

Jpn J Clin Oncol 2019 Apr 22. Epub 2019 Apr 22.

Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan.

Objective: Post-marketing surveillance (PMS) was performed in Japan to obtain information on the safety and efficacy of crizotinib.

Methods: Target patients included almost all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer who were administered crizotinib. The observation period was 52 weeks. Read More

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http://dx.doi.org/10.1093/jjco/hyz049DOI Listing

The immune checkpoint molecules PD-1, PD-L1, TIM-3 and LAG-3 in diffuse large B-cell lymphoma.

Oncotarget 2019 Mar 12;10(21):2030-2040. Epub 2019 Mar 12.

Division of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Signaling through immune checkpoint receptors may lead to T-cell exhaustion and function as immune escape mechanisms in cancer. For diffuse large B-cell lymphoma (DLBCL), the mechanistic and prognostic importance of these markers on tumor cells and the tumor microenvironment remains unclear. We determined the immunohistochemical expression of PD-1, PD-L1, TIM-3, and LAG-3 on tumor cells and on tumor infiltrating lymphocytes (TILs) among 123 DLBCL patients. Read More

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http://www.oncotarget.com/fulltext/26771
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http://dx.doi.org/10.18632/oncotarget.26771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459346PMC
March 2019
1 Read

About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto's disease.

Pan Afr Med J 2018 3;31:77. Epub 2018 Oct 3.

ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

Kikuchi-Fujimoto's disease KFD is a rare and benign cause of cervical lymphadenopathy. It is an anatomoclinical entity of unknown etiology. The confirmation of the diagnosis is always provided by histological lymph node study. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.77.16569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457726PMC
October 2018

[Macrophage activation syndrome revealing subcutaneous T-cell lymphoma in a 16-year old adolescent].

Pan Afr Med J 2018 2;31:74. Epub 2018 Oct 2.

Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Service de Pédiatrie CHU Hassan II, Fès, Maroc.

Macrophage activation syndrome (MAS) is a multisystemic disorder resulting from an over-activation of the immune system leading to a more or less diffuse macrophagic infiltration into the tussues. Clinical signs including fever, hepatosplenomegaly, adenopathy are associated with abnormal values in laboratory test results (bi or pancytopenia, hepatic cytolysis, elevated LDH levels, coagulopathy) and hemophagocytosis. In children, it can be primary or secondary to several disorders. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.74.14686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457733PMC
October 2018

Detection of Extranodal and Spleen Involvement by FDG-PET Imaging Predicts Adverse Survival in Untreated Follicular Lymphoma.

Am J Hematol 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.

Predicting early clinical failure in patients with untreated follicular lymphoma (FL) is important but difficult. This study aimed to determine the incidence and patterns of extranodal (EN) and spleen disease using PET/CT, and assess their utility in predicting early clinical failure. PET/CT images from 613 cases of untreated FL (2003 - 2016) were reviewed. Read More

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http://dx.doi.org/10.1002/ajh.25493DOI Listing

Dermoscopy of Pagetoid reticulosis, with dermoscopic-pathologic correlation.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

First Dermatology Department, Aristotle University of Thessaloniki, Greece.

Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a rare variant of mycosis fungoides with distinctive clinicopathologic features. It clinically manifests as a solitary, erythematous, gradually enlarging, scaly or verrucous plaque on the lower extremities, and due to its indolent course and non-specific clinical features, may remain undiagnosed for years. In the current we describe the clinical and dermoscopic characteristics of a rare case of PR disease, and correlate them with the corresponding histopathologic findings. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12472
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http://dx.doi.org/10.1111/phpp.12472DOI Listing
April 2019
4 Reads

Description of the BRIGHTLIGHT cohort: the evaluation of teenage and young adult cancer services in England.

BMJ Open 2019 Apr 20;9(4):e027797. Epub 2019 Apr 20.

Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.

Objective: International recognition of the unique needs of young people with cancer is growing. Many countries have developed specialist age-appropriate cancer services believing them to be of value. In England, 13 specialist principal treatment centres (PTCs) deliver cancer care to young people. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027797DOI Listing

Incidence, Clinical Features, and Outcomes of Langerhans Cell Sarcoma in the United States.

Clin Lymphoma Myeloma Leuk 2019 Apr 1. Epub 2019 Apr 1.

Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address:

Background: Limited knowledge exists on the incidence, treatment patterns, and long-term outcomes of Langerhans cell sarcoma (LCS) in the United States.

Patients And Methods: We performed a retrospective study of LCS patients diagnosed between 2001 and 2014 using the Surveillance, Epidemiology, and End Results (SEER) and National Cancer Data Base (NCDB) databases. Incidence was calculated from SEER, and treatment patterns and outcomes were calculated from NCDB. Read More

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http://dx.doi.org/10.1016/j.clml.2019.03.026DOI Listing

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.

Mol Ther 2019 Apr 8. Epub 2019 Apr 8.

Allogene Therapeutics, Inc., 210 E. Grand Avenue, South San Francisco, CA 94080, USA. Electronic address:

Clinical success of autologous CD19-directed chimeric antigen receptor T cells (CAR Ts) in acute lymphoblastic leukemia and non-Hodgkin lymphoma suggests that CAR Ts may be a promising therapy for hematological malignancies, including multiple myeloma. However, autologous CAR T therapies have limitations that may impact clinical use, including lengthy vein-to-vein time and manufacturing constraints. Allogeneic CAR T (AlloCAR T) therapies may overcome these innate limitations of autologous CAR T therapies. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.04.001DOI Listing

Lymph node fine-needle cytology in the era of personalized medicine. Is there a role?

Cytopathology 2019 Apr 20. Epub 2019 Apr 20.

Universita degli Studi di Salerno, Medicine and Surgery, Fisciano, Campania, IT.

The 2016 WHO revised classification of lymphoma has sub-classified well defined entities and added a number of provisional entities on the basis of new knowledge on genetic, epigenetics and phenotypical data; prognostic and predictive features are also part of this classification. New knowledge on well-defined entities further enlightens the mechanisms of lymphomagenesis, which are more complex and multifactorial than once believed. Therapies are also more complex because traditional clinical trials have been integrated with new drugs and compounds with unique mechanisms of actions against distinct molecular targets. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cyt.12708
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http://dx.doi.org/10.1111/cyt.12708DOI Listing
April 2019
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Ingenol mebutate for mycosis fungoides.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18018
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http://dx.doi.org/10.1111/bjd.18018DOI Listing
April 2019
5 Reads

Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases.

Sci Rep 2019 Apr 19;9(1):6308. Epub 2019 Apr 19.

Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.

GM3 (monosialodihexosylganglioside) is a type of ganglioside, which is a molecule composed of ceramide and oligosaccharide containing one or more sialic acids. Since GM3 is abundantly expressed in blood cells, we investigated the association between GM3 molecular species and haematological diseases. We measured the serum levels of seven GM3 molecular species in subjects with various haematological diseases (n = 52) and healthy subjects (n = 24) using a liquid chromatography tandem-mass spectrometry technique as an exploratory study. Read More

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http://dx.doi.org/10.1038/s41598-019-42817-3DOI Listing

Co-targeting of BCL2 with venetoclax and MCL1 with S63845 is synthetically lethal in relapsed mantle cell lymphoma.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Pathological Physiology and First Dept. of Medicine- Hematology, Charles University General Hospital and First Faculty of Medicine

Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug venetoclax (VTX) has promising anticancer activity in MCL. We analyzed molecular mechanisms of VTX resistance in MCL cells, and tested strategies to overcome it. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3275DOI Listing

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019
1 Read
1.928 Impact Factor

Association of Occupational Pesticide Exposure With Immunochemotherapy Response and Survival Among Patients With Diffuse Large B-Cell Lymphoma.

JAMA Netw Open 2019 Apr 5;2(4):e192093. Epub 2019 Apr 5.

Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, Nîmes University Hospital, University of Montpellier, Montpellier, France.

Importance: Professional use of pesticides is a risk factor for non-Hodgkin lymphoma. The main biological mechanisms of pesticides and chemotherapy are genotoxicity and reactive oxygen species generation. Cellular adaptation among patients exposed to low doses of genotoxic and oxidative compounds might hinder chemotherapy efficiency in patients with lymphoma. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2093DOI Listing

Investigating the potential benefit of second biopsy of residual mass in pediatric mature B cell non-Hodgkin lymphoma.

Pediatr Hematol Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

a Department of Hematology/Oncology , Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China.

Objectives: To assess the impact of second-look biopsy of residual mass during or after chemotherapy in pediatric mature B-cell NHL.

Methods: Patients with mature B-cell non-Hodgkin lymphoma (NHL) who were suspicious of radiological residual mass at mid or end of treatment and subjected to second biopsy were treated at our center between January 2001 and December 2015. Their clinical characteristics, imaging findings, pathological changes, management, and prognosis were reviewed retrospectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2019.1
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http://dx.doi.org/10.1080/08880018.2019.1597231DOI Listing
April 2019
1 Read

Effect of IL-6-mediated STAT3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3042-3050

Department of Geriatrics, Quanzhou First Hospital of Fujian Medical University, Quanzhou, China.

Objective: To investigate the effect of interleukin-6 (IL-6) gene knockout on apoptosis of myocardial cells in mice with Coxsackievirus B3 (CVB3)-induced dilated cardiomyopathy (DCM) and its potential mechanism, so as to provide certain references for the clinical prevention and treatment of DCM.

Materials And Methods: A total of 40 male C57 mice were randomly divided into Sham group (n=20) and DCM group (n=20) using a random number table. Another 20 mice with IL-6 gene knockout were enrolled into DCM+IL-6 KO group (n=20). Read More

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http://www.europeanreview.org/article/17586
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http://dx.doi.org/10.26355/eurrev_201904_17586DOI Listing
April 2019
2 Reads

Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin.

Ann Hematol 2019 Apr 19. Epub 2019 Apr 19.

Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Extranodal NK/T cell lymphoma (NKTCL), nasal type (ENKL) that shows no apparent nasal involvement, is termed extranasal NKTCL or non-nasal NKTCL. In this study, we aimed to explore therapeutic approaches and outcomes in patients with extranasal NKTCL in current clinical practice. A data set of patients with newly diagnosed NKTCL who were diagnosed at 31 institutes in Japan between 2000 and 2013 was used for analysis. Read More

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http://dx.doi.org/10.1007/s00277-019-03689-9DOI Listing
April 2019
2 Reads

Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

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http://link.springer.com/10.1007/s00234-019-02215-y
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http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
1 Read

Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells.

EBioMedicine 2019 Apr 15. Epub 2019 Apr 15.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Background: Certain tumors rely heavily on their DNA repair capability to survive the DNA damage induced by chemotherapeutic agents. Therefore, it is important to monitor the dynamics of DNA repair in patient samples during the course of their treatment, in order to determine whether a particular drug regimen perturbs the DNA repair networks in cancer cells and provides therapeutic benefits. Quantitative measurement of proteins and/or their posttranslational modification(s) at DNA double strand breaks (DSBs) induced by laser microirradiation provides an applicable diagnostic approach to examine DNA repair and its dynamics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193022
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http://dx.doi.org/10.1016/j.ebiom.2019.03.083DOI Listing
April 2019
1 Read

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

[Exploration of the Role of Tumor Suppressor Genes Foxo1 and PTEN in the Tumorigenesis of Mouse Natural Killer-Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):439-444

Clinical College of 307 Hospital, PLA, Anhui Medical University; Hefei 230032, Anhui Province, China,Department of Lymphoma, General Hospital of PLA Fifth Medical Center, Beijing 100071,

Objective: To explore whether tumor suppressor gene Foxo1 and PTEN play a critical role in the tumorigenesis of mouse natural killer-cell lymphoma.

Methods: NKp46-iCre mice were crossed with mice carrying floxed Foxo1 alleles (Foxo1) as well as floxed PTEN alleles (PTEN) to generate mice in which Foxo1 and PTEN in NK cells were knock-out, referred as Foxo1PTEN. The growth and development of the mice and tumor formation were observed. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.021DOI Listing
April 2019
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[Clinical Analysis of 37 Patients with Primary Tonsil Diffuse Large B Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):426-432

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital) , Nanjing 210029, Jiangsu province, China,E-mail:

Objective: To investigate the clinical manifestation, immunophenotypes and prognostic factors of patients with primary tonsil afftive large B cell lymphoma ( PT-DLBCL ).

Methods: The clinical data including clinical characterstics, typing, staging, treatment efficacy and prognostic factors of PT-DLBCL patients were collected and analyzed restrospectively.

Results: Out of 36 cases with the detinite cell origin, 24 cases (66. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.019DOI Listing

[Clinical role of Morphology in Diagnosing Bone Marrow Involvement of Diffuse Large B Bell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):421-425

Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China,E-mail:

Objective: To determine the significance of morphology of bone marrow smear for diagnosis of bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL), and to study the morphological characteristics of DLBCL cells involved in bone marrow.

Methods: Four hundred and twenty cases of DLBCL diagnosed at Peking Union Hospital from 2006 to 2016 were analyzed and identified.

Results: Blinded analysis of bone marrow smear and bone marrow biopsy data showed involvement in 42 cases on smears (S), in 47cases by biopsy (B) and the in 49 cases by (S+B). Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.018DOI Listing

Clinical value of molecular MRD monitoring by next-generation sequencing in patients with IDH2 mutated AML.

Leuk Lymphoma 2019 Apr 18:1-3. Epub 2019 Apr 18.

c University Department of Hematology and Central Hematology Laboratory , Inselspital, Bern University Hospital , Bern , Switzerland.

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http://dx.doi.org/10.1080/10428194.2019.1585838DOI Listing

Variant allele frequencies do not correlate well with myeloblast counts in a clinically validated gene sequencing panel for routine acute myeloid leukemia workup.

Leuk Lymphoma 2019 Apr 18:1-8. Epub 2019 Apr 18.

a Department of Pathology and Laboratory Medicine , Dartmouth-Hitchcock Medical Center One Medical Center Drive , Lebanon , NH , USA.

Next generation sequencing (NGS) has introduced new types of data, such as variant allele frequencies (VAFs), into the workup of acute myeloid leukemias (AML). There is interest in using NGS to prognosticate disease behavior and monitor residual disease, but the attribution of sequencing data entirely to the leukemic clone may be confounded by VAF contribution from background non-leukemic populations and undetected copy number aberrations. Sixty-eight patients with AML were evaluated by a clinically validated gene sequencing panel at our institution from 2015 to 2018. Read More

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http://dx.doi.org/10.1080/10428194.2019.1587757DOI Listing
April 2019
1 Read

FLT3 inhibitor quizartinib (AC220).

Leuk Lymphoma 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Leukemia , University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Acute myeloid leukemia (AML) is a heterogeneous disease and remains a therapeutic challenge. Cytogenetics is a well-established prognostic factor. Recent discovery of molecular mutations has gained momentum with some being potential therapeutic targets. Read More

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http://dx.doi.org/10.1080/10428194.2019.1602263DOI Listing
April 2019
1 Read

A prospective non-interventional study on the impact of transfusion burden and related iron toxicity on outcome in myelodysplastic syndromes undergoing allogeneic hematopoietic cell transplantation.

Leuk Lymphoma 2019 Apr 18:1-10. Epub 2019 Apr 18.

u University Hospital Eppendorf , Hamburg , Germany.

Most myelodysplastic syndromes (MDS)-patients receive multiple red blood cell transfusions (RBCT). Transfusions may cause iron-related toxicity and mortality, influencing outcome after allogeneic HSCT. This prospective non-interventional study evaluated 222 MDS and CMML patients undergoing HSCT. Read More

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http://dx.doi.org/10.1080/10428194.2019.1594215DOI Listing

Risk factors for neutropenia and febrile neutropenia following prophylactic pegfilgrastim.

Asia Pac J Clin Oncol 2019 Apr 17. Epub 2019 Apr 17.

College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.

Aim: Neutropenia is a common side effect of myelosuppressive chemotherapy. Administration of granulocyte colony-stimulating factor is being used for neutropenia prophylaxis, but there are patients who develop neutropenia or febrile neutropenia despite prophylaxis. We attempted to identify potential risk factors for chemotherapy-induced neutropenia in patients with pegfilgrastim prophylaxis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.13152
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http://dx.doi.org/10.1111/ajco.13152DOI Listing
April 2019
2 Reads

Metastatic melanoma vs lymphoma. Using a sentinel lymph node biopsy a diagnostic tool.

J Surg Case Rep 2019 Apr 12;2019(4):rjz117. Epub 2019 Apr 12.

Plastic Surgery Department, Queen Elizabeth Hospital of Birmingham, Mindelsohn Way, Birmingham, West Midlands B15 2TH, UK.

Sentinel lymph node biopsy (SLNB) is a prognostic tool used in cases of melanoma with a stage IB or greater and the absence of clinical lymphadenopathy. A positive SLNB historically indicated a need for regional lymph node clearance. However, cases of clinical lymphadenopathy in the presence of primary melanoma negates the use of SLNB and rather the British Association of Dermatologists advocate a primary block dissection of regional lymphatic tissue [NICE UK. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz11
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http://dx.doi.org/10.1093/jscr/rjz117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460898PMC
April 2019
2 Reads

Prognostic value of F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation.

Chin J Cancer Res 2019 Feb;31(1):162-170

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: High-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma (DLBCL) patients. F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of F-FDG PET/CT pre- and post-HSCT in predicting outcomes of patients with DLBCL. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433590PMC
February 2019

Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin: Analysis of 1,085 WHO classified cases in a single institution in China.

Chin J Cancer Res 2019 Feb;31(1):152-161

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma (DLBCL) patients in China according to the primary site.

Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433587PMC
February 2019
2 Reads

Clinical Features, Pathological Features, and Treatment Outcomes of 22 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated with a Humanized CCR4 Antibody (Mogamulizumab) at a Single Institution during a 6-year Period (2012-2018).

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, Kurume University, Japan.

Objective To elucidate the clinical impact of humanized CCR4 antibody (mogamulizumab) on adult T-cell leukemia-lymphoma (ATL), we retrospectively analyzed the clinical and pathological features and treatment outcomes of aggressive ATL. Methods Twenty-two patients (median age: 65 years) with aggressive ATL (acute- [n=16] or lymphoma-type [n=6]) had their characteristics analyzed. All cases were treated with mogamulizumab at our institution from 2012 to 2018. Read More

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http://dx.doi.org/10.2169/internalmedicine.2513-18DOI Listing

A Case of Exophiala dermatitidis Fungemia Diagnosed using Time-of-flight Mass Spectrometry during Chemotherapy for Malignant Lymphoma and Successful Treatment with Voriconazole.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology & Oncology, Nagoya City University Hospital, Japan.

Infectious diseases, including those caused by fungi, remain important issues in patients receiving malignant lymphoma chemotherapy. We herein report a rare case of Exophiala dermatitidis fungemia during chemotherapy in a 67-year-old woman admitted to our hospital. She had a fever that could not be resolved despite antifungal therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.2082-18DOI Listing

Steroid-induced Bradycardia During Induction Chemotherapy in Children and Young Adults Diagnosed With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma.

J Pediatr Hematol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Pediatrics, Division of Pediatric Hematology and Oncology, Monroe Carell Jr Children's Hospital at Vanderbilt.

Systemic corticosteroids are widely used for the treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma. Anecdotal case reports demonstrate bradycardia in patients receiving corticosteroids; however, a more in-depth analysis is lacking. This study aimed to describe the incidence, timing, and outcomes of bradycardia in children with ALL receiving corticosteroids during induction chemotherapy at our center from 2010 to 2016. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001483DOI Listing
April 2019
9 Reads

Combined Modality Management of Sinonasal Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma in a Young Adult-Report of a Rare Case.

J Adolesc Young Adult Oncol 2019 Apr 17. Epub 2019 Apr 17.

3 Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Sinonasal anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) without nodal involvement is extremely rare and the rarity of this tumor often leads to diagnostic dilemma. It has been predominantly reported in pediatric, adolescent and young adult patients, mostly of Asian origin. A 21-year-old female patient presented with history of epistaxis for 1 year. Read More

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https://www.liebertpub.com/doi/10.1089/jayao.2018.0158
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http://dx.doi.org/10.1089/jayao.2018.0158DOI Listing
April 2019
2 Reads

Clinical features and outcomes of ALK rearranged non-small cell lung cancer with primary resistance to crizotinib.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Crizotinib is associated with a favorable survival benefit in patients with ALK-positive non-small cell lung cancer (NSCLC); however, a subset of patients harboring ALK rearrangement shows a poor response.

Methods: We collected the clinical features and survival outcomes of 28 primary-resistant responders (PRR) with progression-free survival (PFS) of < 3 months on crizotinib and compared these with 78 long-term responders (LTR) that achieved > 24 months PFS (control).

Results: Primary resistance was observed in 6. Read More

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http://dx.doi.org/10.1111/1759-7714.13071DOI Listing
April 2019
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PACAP Attenuates Optic Nerve Crush-Induced Retinal Ganglion Cell Apoptosis Via Activation of the CREB-Bcl-2 Pathway.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Retinal ganglion cell (RGC) apoptosis is considered an important pathological hallmark of glaucoma. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with potent neuroprotective properties. In our previous study, we found that the expression of PACAP and its high-affinity receptor PACAP receptor type 1 (PAC1R) increased markedly after optic nerve crush (ONC), and occurred mainly in the ganglion cell layer of the retina. Read More

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http://dx.doi.org/10.1007/s12031-019-01309-9DOI Listing

Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later.

Drugs R D 2019 Apr 16. Epub 2019 Apr 16.

Department of Hematology, Medical University of Lodz, Ul. Ciolkowskiego 2, 93-510, Lodz, Poland.

Bortezomib is a dipeptidyl boronic acid that selectively inhibits the ubiquitin proteasome pathway, which plays a role in the degradation of many intracellular proteins. It is the first-in-class selective and reversible inhibitor of the 26S proteasome, with antiproliferative and antitumor activity. It exerts its anti-neoplastic action mainly via the inhibition of the nuclear factor-κB pathway components associated with cell proliferation, apoptosis, and angiogenesis. Read More

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http://dx.doi.org/10.1007/s40268-019-0269-9DOI Listing

Special Considerations in the Treatment of Mycosis Fungoides.

Am J Clin Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel College at Jefferson University Hospital, Thomas Jefferson University, 833 Chestnut Street, Suite 740, Philadelphia, PA, 19107, USA.

Mycosis fungoides is the most common form of cutaneous T cell lymphoma. Although normally presenting to physicians at an early stage and with an indolent course, mycosis fungoides can have a varied presentation. The National Comprehensive Cancer Network (NCCN) has created guidelines for the treatment and staging of mycosis fungoides. Read More

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http://dx.doi.org/10.1007/s40257-019-00431-zDOI Listing
April 2019
8 Reads

Long-term outcomes of superficial neoplasia at the esophagogastric junction treated via endoscopic submucosal dissection and endoscopic submucosal tunnel dissection: a cohort study of a single center from China.

Surg Endosc 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.

Background And Aims: The techniques and indications for endoscopic submucosal dissection (ESD) and endoscopic submucosal tunnel dissection (ESTD) to remove superficial neoplasia at the esophagogastric junction (EGJ) have been developed and expanded. However, the resection of superficial neoplasia at the EGJ by ESD remains challenging, and the long-term clinical outcomes of curative and non-curative resections based on histological criteria remain unclear. We conducted a retrospective analysis on the safety and efficacy of the ESD and ESTD procedure with these patients. Read More

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http://dx.doi.org/10.1007/s00464-019-06753-7DOI Listing
April 2019
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Current advances in Hodgkin's lymphoma.

Chronic Dis Transl Med 2019 Mar 19;5(1):15-24. Epub 2019 Mar 19.

Department of Hematology and Oncology, Geisinger Medical Center, Danville, PA 17822, USA.

Hodgkin's lymphoma is a highly treatable malignancy. It has high cure rates yet there are many patients who relapse or are refractory to treatment. Traditionally, treatment has been with conventional chemotherapy; however, the development of brentuximab vedotin and immune checkpoint inhibitors has revolutionized the care of Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.1016/j.cdtm.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450804PMC

Cytomegalovirus infection in a T-cell lymphoma patient presenting with multiple gastrointestinal ulcers: a case report.

Endosc Int Open 2019 Apr 12;7(4):E615-E620. Epub 2019 Apr 12.

Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Gastrointestinal ulcers are responsible for a wide spectrum of diseases. Infection, drug-induced enteritis, malignancy, vasculitis and Inflammatory bowel disease are the most common causes; their clinical expression often varies according to the site and severity of intestinal involvement. We report on a 68-year-old male presenting with dyspepsia and melena and multiple gastrointestinal ulcers on endoscopy. Read More

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http://dx.doi.org/10.1055/a-0869-7828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461553PMC
April 2019
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Optimizing treatment for HIV-associated lymphoma.

Authors:
Ariela Noy

Blood 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Cancer is the leading cause of death for HIV-infected persons in economically developed countries, even in the era of antiretroviral therapy (ART). Lymphomas remain a leading cause of cancer morbidity and mortality for HIV-infected patients and have increased incidence even in patients optimally treated with ART. Even limited interruptions of ART can lead to cluster of differentiation 4 (CD4) cell nadirs and HIV viremia, and increase the risk of lymphoma. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-01
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http://dx.doi.org/10.1182/blood-2018-01-791400DOI Listing
April 2019
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Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in AML.

Leuk Lymphoma 2019 Apr 17:1-8. Epub 2019 Apr 17.

a TIMM Laboratory , Sahlgrenska Cancer Center, Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

Consolidation chemotherapy in acute myeloid leukemia (AML) aims at eradicating residual leukemic cells and mostly comprises high-dose cytarabine with or without the addition of anthracyclines, including daunorubicin. Immunogenic cell death (ICD) may contribute to the efficacy of anthracyclines in solid cancer, but the impact of ICD in AML is only partly explored. We assessed aspects of ICD, as reflected by calreticulin expression, in primary human AML blasts and observed induction of surface calreticulin upon exposure to daunorubicin but not to cytarabine. Read More

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http://dx.doi.org/10.1080/10428194.2019.1599110DOI Listing
April 2019
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Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers.

J Clin Med 2019 Apr 15;8(4). Epub 2019 Apr 15.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.

C1QBP (Complement Component 1 Q Subcomponent-Binding Protein), a multicompartmental protein, participates in various cellular processes, including mRNA splicing, ribosome biogenesis, protein synthesis in mitochondria, apoptosis, transcriptional regulation, and infection processes of viruses. The correlation of C1QBP expression with patient survival and molecular function of C1QBP in relation to cancer progression has not been comprehensively studied. Therefore, we sought to systematically investigate the expression of C1QBP to evaluate the change of C1QBP expression and the relationship with patient survival and affected pathways in breast, lung, colon, and bladder cancers as well as lymphoma. Read More

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http://dx.doi.org/10.3390/jcm8040513DOI Listing

X-Linked Lymphoproliferative Syndrome Presenting as Adult-Onset Multi-Infarct Dementia.

J Neuropathol Exp Neurol 2019 May;78(5):460-466

Department of Neurology, Mayo Clinic, Jacksonville, Florida.

Pathogenic hemizygous variants in the SH2D1A gene cause X-linked lymphoproliferative (XLP) syndrome, a rare primary immunodeficiency usually associated with fatal Epstein-Barr virus infection. Disease onset is typically in early childhood, and the average life expectancy of affected males is ∼11 years. We describe clinical, radiographic, neuropathologic, and genetic features of a 49-year-old man presenting with central nervous system vasculitis that was reminiscent of adult primary angiitis but which was unresponsive to treatment. Read More

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https://academic.oup.com/jnen/article/78/5/460/5445919
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http://dx.doi.org/10.1093/jnen/nlz018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467195PMC
May 2019
3 Reads

[Post Radiotherapy Lesions of the Heart Valves. Principles of Diagnosis and Results of Treatment].

Kardiologiia 2019 Apr 12;59(3):36-42. Epub 2019 Apr 12.

A. N. Bakoulev Scientific Center for Cardiovascular Surgery.

Background: The use of radiation therapy for the treatment of tumors of the chest сan lead to the development of cardiac pathology, including that of the valves and coronary arteries.

Study Aim: to analyze the specifics of post-radiation lesions of the valvular apparatus and coronary arteries, and to assess the immediate results and risks of surgical correction of detected defects. Materials and  methods. Read More

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http://dx.doi.org/10.18087/cardio.2019.3.10239DOI Listing
April 2019
1 Read