3,938 results match your criteria Clinical Journal of the American Society of Nephrology CJASN[Journal]


Major Adverse Kidney Events in Pediatric Sepsis.

Clin J Am Soc Nephrol 2019 Apr 18. Epub 2019 Apr 18.

Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Background And Objectives: Major adverse kidney events, a composite of death, new kidney replacement therapy, or persistent kidney dysfunction, is a potential patient-centered outcome for clinical trials in sepsis-associated kidney injury. We sought to determine the incidence of major adverse kidney events within 30 days and validate this end point in pediatric sepsis.

Design, Setting, Participants, & Measurements: We conducted a retrospective observational study using the Pediatric Health Information Systems Plus database of patients >6 months to <18 years old with a diagnosis of severe sepsis/septic shock; orders for bacterial blood culture, antibiotics, and at least one fluid bolus on hospital day 0/1; and known hospital disposition between January 2007 and December 2011. Read More

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http://dx.doi.org/10.2215/CJN.12201018DOI Listing

Hypoglycemia in People with Type 2 Diabetes and CKD.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Kidney Research Institute.

Background And Objectives: Among people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.

Design, Setting, Participants & Measurements: We enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11650918
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http://dx.doi.org/10.2215/CJN.11650918DOI Listing
April 2019
1 Read

Hepatorenal Syndrome.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatorenal syndrome is a severe complication of end-stage cirrhosis characterized by increased splanchnic blood flow, hyperdynamic state, a state of decreased central volume, activation of vasoconstrictor systems, and extreme kidney vasoconstriction leading to decreased GFR. The contribution of systemic inflammation, a key feature of cirrhosis, in the development of hepatorenal syndrome has been highlighted in recent years. The mechanisms by which systemic inflammation precipitates kidney circulatory changes during hepatorenal syndrome need to be clarified. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12451018
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http://dx.doi.org/10.2215/CJN.12451018DOI Listing
April 2019
2 Reads

Safety of Dynamic Intravenous Iron Administration Strategies in Hemodialysis Patients.

Clin J Am Soc Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology.

Background And Objectives: Intravenous iron therapy for chronic anemia management is largely driven by dosing protocols that differ in intensity with respect to dosing approach (, dose, frequency, and duration). Little is known about the safety of these protocols.

Design, Setting, Participants, & Measurements: Using clinical data from a large United States dialysis provider linked to health care utilization data from Medicare, we constructed a cohort of patients with ESKD aged ≥65 years who initiated and continued center-based hemodialysis for ≥90 days between 2009 and 2012, and initiated at least one of the five common intravenous iron administration strategies; ranked by intensity (the amount of iron given at moderate-to-high iron indices), the order of strategies was 3 (least intensive), 2 (less intensive), 1 (reference), 4 (more intensive), and 5 (most intensive). Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.03970318
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http://dx.doi.org/10.2215/CJN.03970318DOI Listing
April 2019
2 Reads

Treatment Options for Refractory Lupus Nephritis.

Clin J Am Soc Nephrol 2019 Apr 12. Epub 2019 Apr 12.

Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.2215/CJN.03230319DOI Listing
April 2019
1 Read

Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis.

Clin J Am Soc Nephrol 2019 Apr 12. Epub 2019 Apr 12.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Background And Objectives: Our study evaluated the efficiency and safety of autologous hematopoietic stem cell transplantation treatment for patients with refractory lupus nephritis.

Design, Setting, Participants, & Measurements: From July 2011 to January 2015, a total of 22 patients with refractory lupus nephritis were enrolled in this study. Peripheral blood stem cells were mobilized with cyclophosphamide and granulocyte colony stimulating factor and reinfused after treatment with cyclophosphamide and antithymocyte globulin. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10570918
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http://dx.doi.org/10.2215/CJN.10570918DOI Listing
April 2019
2 Reads

Vascular Access for Hemodialysis Patients: New Data Should Guide Decision Making.

Authors:
Michael Allon

Clin J Am Soc Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama

This commentary critically examines key assumptions and recommendations in the 2006 Kidney Disease Outcomes Quality Initiative vascular access guidelines, and argues that several are not relevant to the contemporary United States hemodialysis population. First, the guidelines prefer arteriovenous fistulas (AVFs) over arteriovenous grafts (AVGs), on the basis of their superior secondary survival and lower frequency of interventions and infections. However, intent-to-treat analyses that incorporate the higher primary failure of AVFs, demonstrate equivalent secondary survival of both access types. Read More

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http://dx.doi.org/10.2215/CJN.00490119DOI Listing
April 2019
1 Read

Pruritus and Patient Reported Outcomes in Non-Dialysis CKD.

Clin J Am Soc Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Arbor Research Collaborative for Health, Ann Arbor, Michigan.

Background And Objectives: Among patients on hemodialysis, pruritus has been associated with poorer mental and physical quality of life, sleep quality, depression, and mortality. We evaluated patients with nondialysis CKD to describe the prevalence of pruritus, identify associated factors, and investigate associations with patient-reported outcomes.

Design, Setting, Participants, & Measurements: Using cross-sectional data from patient questionnaires in the CKD Outcomes and Practice Patterns Study (CKDopps), we asked patients with CKD stages 3-5 (nondialysis) from the United States, Brazil, and France to identify how much they were bothered by pruritus. Read More

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http://dx.doi.org/10.2215/CJN.09600818DOI Listing
April 2019
3 Reads

Blood Microbiome in CKD: Should We Care?

Clin J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California; and

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http://dx.doi.org/10.2215/CJN.03420319DOI Listing

Serum Metabolites and Cardiac Death in Patients on Hemodialysis.

Clin J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University School of Medicine, Baltimore, Maryland;

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http://dx.doi.org/10.2215/CJN.12691018DOI Listing

Blood Microbiome Profile in CKD : A Pilot Study.

Clin J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Massachusetts General Hospital for Children, Boston, Massachusetts.

Background And Objectives: The association between gut dysbiosis, high intestinal permeability, and endotoxemia-mediated inflammation is well established in CKD. However, changes in the circulating microbiome in patients with CKD have not been studied. In this pilot study, we compare the blood microbiome profile between patients with CKD and healthy controls using 16S ribosomal DNA sequencing. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.12161018
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http://dx.doi.org/10.2215/CJN.12161018DOI Listing
April 2019
6 Reads

Management of Adult Minimal Change Disease.

Clin J Am Soc Nephrol 2019 Apr 5. Epub 2019 Apr 5.

Division of Nephrology, Department of Medicine, Rush University Medical Center, Chicago, Illinois.

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01920219
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http://dx.doi.org/10.2215/CJN.01920219DOI Listing
April 2019
9 Reads

A Case of ANCA-Associated Vasculitis.

Authors:
Jonathan J Hogan

Clin J Am Soc Nephrol 2019 Apr 5. Epub 2019 Apr 5.

Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.2215/CJN.14601218DOI Listing
April 2019
1 Read

Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.

Clin J Am Soc Nephrol 2019 Apr 4. Epub 2019 Apr 4.

Division of Nephrology, Department of Medicine, and

Background And Objectives: Hypernatremia is common in hospitalized, critically ill patients. Although there are no clear guidelines on sodium correction rate for hypernatremia, some studies suggest a reduction rate not to exceed 0.5 mmol/L per hour. Read More

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http://dx.doi.org/10.2215/CJN.10640918DOI Listing
April 2019
1 Read

Diagnostic Performance of Blood Pressure Measurement Modalities in Living Kidney Donor Candidates.

Clin J Am Soc Nephrol 2019 Apr 4. Epub 2019 Apr 4.

Department of Nephrology and Glickman Urological and Kidney Institute, and

Background And Objectives: Precise BP measurement to exclude hypertension is critical in evaluating potential living kidney donors. Ambulatory BP monitoring is considered the gold standard method for diagnosing hypertension, but it is cumbersome to perform. We sought to determine whether lower BP cutoffs using office and automated BP would reduce the rate of missed hypertension in potential living donors. Read More

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http://dx.doi.org/10.2215/CJN.02780218DOI Listing
April 2019
1 Read

Clinical Pharmacology in Diuretic Use.

Authors:
David H Ellison

Clin J Am Soc Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Departments of Medicine and

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http://dx.doi.org/10.2215/CJN.09630818DOI Listing
April 2019
1 Read

Place of Percutaneous Fistula Devices in Contemporary Management of Vascular Access.

Authors:
Haimanot Wasse

Clin J Am Soc Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Department of Medicine, Renal Division, Rush University Medical Center, Chicago, Illinois

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http://dx.doi.org/10.2215/CJN.00980119DOI Listing
April 2019
1 Read

Prediction Models for AKI: Will They Result in Improved Outcomes for AKI?

Clin J Am Soc Nephrol 2019 Apr 27;14(4):488-490. Epub 2019 Mar 27.

Division of Nephrology, Department of Medicine and

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http://dx.doi.org/10.2215/CJN.02250219DOI Listing
April 2019
1 Read

Transitional Care Units: Greater Than the Sum of Their Parts.

Authors:
Brendan T Bowman

Clin J Am Soc Nephrol 2019 Mar 27. Epub 2019 Mar 27.

Division of Nephrology, University of Virginia School of Medicine, Charlottesville, Virginia

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http://dx.doi.org/10.2215/CJN.12301018DOI Listing

Retooling Nephrology with Ultrasound.

Clin J Am Soc Nephrol 2019 Mar 27. Epub 2019 Mar 27.

Division of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Great Neck, New York.

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http://dx.doi.org/10.2215/CJN.10430818DOI Listing

How Community Engagement Is Enhancing NIDDK Research.

Clin J Am Soc Nephrol 2019 Mar 27. Epub 2019 Mar 27.

Division of Kidney, Urologic and Hematologic Disease, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; and.

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http://dx.doi.org/10.2215/CJN.14591218DOI Listing
March 2019
5 Reads

A Prediction Model for Severe AKI in Critically Ill Adults That Incorporates Clinical and Biomarker Data.

Clin J Am Soc Nephrol 2019 Apr 27;14(4):506-514. Epub 2019 Mar 27.

Division of Pulmonary and Critical Care Medicine, Department of Medicine.

Background And Objectives: Critically ill patients with worsening AKI are at high risk for poor outcomes. Predicting which patients will experience progression of AKI remains elusive. We sought to develop and validate a risk model for predicting severe AKI within 72 hours after intensive care unit admission. Read More

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http://dx.doi.org/10.2215/CJN.04100318DOI Listing
April 2019
1 Read

Correction.

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Clin J Am Soc Nephrol 2019 Mar 22. Epub 2019 Mar 22.

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http://dx.doi.org/10.2215/CJN.02630319DOI Listing

Patient Perspective of Smartphone-Based Apps for CKD Self-Care.

Authors:
Dale Rogers

Clin J Am Soc Nephrol 2019 Apr 21;14(4):483-484. Epub 2019 Mar 21.

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http://dx.doi.org/10.2215/CJN.02220219DOI Listing

Got CKD? There's an App for That!

Clin J Am Soc Nephrol 2019 Apr 21;14(4):491-492. Epub 2019 Mar 21.

Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

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http://dx.doi.org/10.2215/CJN.02350219DOI Listing

Patients' and Nephrologists' Evaluation of Patient-Facing Smartphone Apps for CKD.

Clin J Am Soc Nephrol 2019 Apr 21;14(4):523-529. Epub 2019 Mar 21.

Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.

Background And Objectives: Many aspects of CKD management rely heavily on patient self-care, including medication and dietary adherence, self-monitoring of BP, and daily physical activity. Growing evidence suggests that incorporating smartphone-based applications can support self-care in CKD and chronic disease more generally.

Design, Setting, Participants, & Measurements: We identified applications targeting patients with CKD by conducting a search of the US Apple App Store (iOS) and Google Play Store (Android) using the following four phrases: "kidney disease," "renal," "dialysis," and "kidney transplant. Read More

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http://dx.doi.org/10.2215/CJN.10370818DOI Listing
April 2019
1 Read

Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI.

Clin J Am Soc Nephrol 2019 Apr 21;14(4):496-505. Epub 2019 Mar 21.

Background And Objectives: Older patients in the intensive care unit are at greater risk of AKI; however, use of kidney replacement therapy in this population is poorly characterized. We describe the triggers and outcomes associated with kidney replacement therapy in older patients with AKI in the intensive care unit.

Design, Setting, Participants, & Measurements: Our study was a prospective cohort study in 16 Canadian hospitals from September 2013 to November 2015. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05530518
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http://dx.doi.org/10.2215/CJN.05530518DOI Listing
April 2019
3 Reads

Complex Decision Making about Dialysis in Critically Ill Older Adults with AKI.

Clin J Am Soc Nephrol 2019 Apr 21;14(4):485-487. Epub 2019 Mar 21.

Department of Medicine and Kidney Research Institute, University of Washington and Hospital and Specialty Medicine and Seattle Denver Center of Innovation, Veterans Affairs Puget Sound Health Care System, Seattle, Washington

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01870219
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http://dx.doi.org/10.2215/CJN.01870219DOI Listing
April 2019
5 Reads

Frailty and Cognitive Deficits Limit Access to Kidney Transplantation: Unfair or Unavoidable?

Clin J Am Soc Nephrol 2019 Apr 19;14(4):493-495. Epub 2019 Mar 19.

Renal-Electrolyte and Hypertension Division and

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.02390219
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http://dx.doi.org/10.2215/CJN.02390219DOI Listing
April 2019
12 Reads

Rates of Cardiac Rhythm Abnormalities in Patients with CKD and Diabetes.

Clin J Am Soc Nephrol 2019 Apr 19;14(4):549-556. Epub 2019 Mar 19.

Kidney Research Institute.

Background And Objectives: Cardiac arrhythmias increase mortality and morbidity in CKD. We evaluated the rates of subclinical arrhythmias in a population with type 2 diabetes and patients with moderate to severe CKD who were not on dialysis.

Design, Setting, Participants & Measurements: This is a prospective observational study, using continuous ambulatory cardiac monitors to determine the rate of atrial and ventricular arrhythmias, as well as conduction abnormalities in this group. Read More

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http://dx.doi.org/10.2215/CJN.09420818DOI Listing
April 2019
2 Reads

Frailty and Access to Kidney Transplantation.

Clin J Am Soc Nephrol 2019 Apr 19;14(4):576-582. Epub 2019 Mar 19.

Department of Surgery,

Background And Objectives: Frailty, a syndrome distinct from comorbidity and disability, is clinically manifested as a decreased resistance to stressors and is present in up to 35% of patient with ESKD. It is associated with falls, hospitalizations, poor cognitive function, and mortality. Also, frailty is associated with poor outcomes after kidney transplant, including delirium and mortality. Read More

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http://dx.doi.org/10.2215/CJN.12921118DOI Listing
April 2019
1 Read

Subclinical Cognitive Impairment and Listing for Kidney Transplantation.

Clin J Am Soc Nephrol 2019 Apr 19;14(4):567-575. Epub 2019 Mar 19.

Departments of Internal Medicine.

Background And Objectives: Cognitive impairment is common in patients with kidney disease and can affect physicians' perception and/or patients' ability to complete the pretransplant evaluation. We examined whether cognitive impairment influences the likelihood for transplant listing and whether patients with cognitive impairment take longer to be listed.

Design, Setting, Participants, & Measurements: We conducted a single-center longitudinal cohort study. Read More

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http://dx.doi.org/10.2215/CJN.11010918DOI Listing
April 2019
3 Reads

Estimation of Kidney Function in Oncology: Implications for Anticancer Drug Selection and Dosing.

Clin J Am Soc Nephrol 2019 Apr 19;14(4):587-595. Epub 2019 Mar 19.

Hematology/Oncology Division, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; and

Estimation of kidney function in patients with cancer directly affects drug dosing, agent selection, and eligibility for clinical trials of novel agents. Overestimation of kidney function may lead to overdosing or inappropriate agent selection and corresponding toxicity. Conversely, underestimation of kidney function may lead to underdosing or inappropriate agent exclusion and subsequent therapeutic failure. Read More

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http://dx.doi.org/10.2215/CJN.11721018DOI Listing
April 2019
1 Read

Correction.

Authors:

Clin J Am Soc Nephrol 2019 Apr 18;14(4):586. Epub 2019 Mar 18.

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http://dx.doi.org/10.2215/CJN.01680219DOI Listing

Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation.

Clin J Am Soc Nephrol 2019 Apr 18;14(4):540-548. Epub 2019 Mar 18.

Department of Pediatrics and Medicine (Nephrology), School of Medicine, University of California, San Diego, La Jolla, California.

Background And Objectives: The neonatal and juvenile human kidney can be exposed to a variety of potentially toxic drugs (, nonsteroidal anti-inflammatory drugs, antibiotics, antivirals, diuretics), many of which are substrates of the kidney organic anion transporters, OAT1 (SLC22A6, originally NKT) and OAT3 (SLC22A8). Despite the immense concern about the consequences of drug toxicity in this vulnerable population, the developmental regulation of OATs in the immature postnatal kidney is poorly understood.

Design, Setting, Participants, & Measurements: Recognizing that today it is difficult to obtain rich data on neonatal kidney handling of OAT probes due to technical, logistic, and ethical considerations, multiple older physiologic studies that used the prototypical organic anion substrate para-aminohippurate (PAH) were reanalyzed in order to provide a quantitative description of OAT-mediated tubular secretion across the pediatric age continuum. Read More

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http://dx.doi.org/10.2215/CJN.10350818DOI Listing
April 2019
1 Read

Kidney Transplantation in a HIV-Positive Recipient.

Clin J Am Soc Nephrol 2019 Apr 18;14(4):614-616. Epub 2019 Mar 18.

Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.2215/CJN.14051118DOI Listing

Estimated Glomerular Filtration Rate and the Risk of Cancer.

Clin J Am Soc Nephrol 2019 Apr 14;14(4):530-539. Epub 2019 Mar 14.

Departments of Medical Epidemiology and Biostatistics and.

Background And Objectives: Community-based reports regarding eGFR and the risk of cancer are conflicting. We here explore plausible links between kidney function and cancer incidence in a large Scandinavian population-based cohort.

Design, Setting, Participants, & Measurements: In the Stockholm Creatinine Measurements project, we quantified the associations of baseline eGFR with the incidence of cancer among 719,033 Swedes ages ≥40 years old with no prior history of cancer. Read More

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http://dx.doi.org/10.2215/CJN.10820918DOI Listing

Usability Testing of a Sick-Day Protocol in CKD.

Clin J Am Soc Nephrol 2019 Apr 13;14(4):583-585. Epub 2019 Mar 13.

Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland;

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http://dx.doi.org/10.2215/CJN.13221118DOI Listing
April 2019
1 Read

Clinical Pharmacology of Antibiotics.

Clin J Am Soc Nephrol 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacy Services, Yale-New Haven Hospital, New Haven, Connecticut.

Antimicrobial pharmacology and its effect on prescribing is quite complex. Selecting an antibiotic that will optimally treat an infection while minimizing adverse effects and the development of resistance is only the first step, as one must also consider the patient's individual pharmacokinetic alterations and the pharmacodynamic properties of the drug when prescribing it as well. Patients with CKD may have alterations in their protein binding, volumes of distribution, kidney clearance, and nonrenal clearance that necessitates antibiotic dose adjustments to prevent the development of toxicity. Read More

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http://dx.doi.org/10.2215/CJN.08140718DOI Listing
March 2019
1 Read

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

Risks of Living Kidney Donation: Current State of Knowledge on Outcomes Important to Donors.

Clin J Am Soc Nephrol 2019 Apr 11;14(4):597-608. Epub 2019 Mar 11.

Department of Surgery and

In the past decade, there have been increasing efforts to better define and quantify the short- and long-term risks of living kidney donation. Recent studies have expanded upon the previous literature by focusing on outcomes that are important to potential and previous donors, applying unique databases and/or registries to follow large cohorts of donors for longer periods of time, and comparing outcomes with healthy nondonor controls to estimate attributable risks of donation. Leading outcomes important to living kidney donors include kidney health, surgical risks, and psychosocial effects of donation. Read More

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http://dx.doi.org/10.2215/CJN.11220918DOI Listing
April 2019
5 Reads

Commentary on Risks of Living Kidney Donation: Current State of Knowledge on Core Outcomes Important to Donors.

Clin J Am Soc Nephrol 2019 Apr 11;14(4):609-610. Epub 2019 Mar 11.

Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland

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http://dx.doi.org/10.2215/CJN.01650219DOI Listing

Secondhand Smoke and CKD.

Clin J Am Soc Nephrol 2019 Apr 7;14(4):515-522. Epub 2019 Mar 7.

Institute of Kidney Disease Research and

Background And Objectives: Active smoking is associated with higher risk of various diseases. However, the risk of CKD development in nonsmokers exposed to secondhand smoke is not well elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Read More

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http://dx.doi.org/10.2215/CJN.09540818DOI Listing

Management of the Hemodialysis Patient with Catheter-Related Bloodstream Infection.

Clin J Am Soc Nephrol 2019 Apr 5;14(4):611-613. Epub 2019 Mar 5.

Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama

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http://dx.doi.org/10.2215/CJN.13171118DOI Listing

Clinical Pharmacology Considerations in Pain Management in Patients with Advanced Kidney Failure.

Authors:
Sara N Davison

Clin J Am Soc Nephrol 2019 Mar 4. Epub 2019 Mar 4.

Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

Pain is common and poorly managed in patients with advanced CKD, likely due to both under and over prescription of appropriate analgesics. Poorly managed pain contributes to patients' poor quality of life and excessive health care use. There is tremendous variability within and between countries in prescribing patterns of analgesics, suggesting that factors other than patient characteristics account for these differences. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.05180418
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http://dx.doi.org/10.2215/CJN.05180418DOI Listing
March 2019
10 Reads

Recommendations for the Care of Patients Receiving Conservative Kidney Management: Focus on Management of CKD and Symptoms.

Clin J Am Soc Nephrol 2019 Apr 28;14(4):626-634. Epub 2019 Feb 28.

Division of Care of the Elderly, Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.

Conservative kidney management is increasingly accepted as an appropriate treatment option for patients with eGFR category 5 CKD who are unlikely to benefit from dialysis and/or who choose a nondialysis care option. However, there remains great variation in the delivery of their care. As part of the development of a conservative kidney management pathway that is undergoing evaluation, a set of recommendations specific to conservative kidney management for managing the complications of CKD and common symptoms was developed. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10510917
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http://dx.doi.org/10.2215/CJN.10510917DOI Listing
April 2019
22 Reads

Secular Trends in the Cost of Immunosuppressants after Solid Organ Transplantation in the United States.

Clin J Am Soc Nephrol 2019 Mar 28;14(3):421-430. Epub 2019 Feb 28.

Arbor Research Collaborative for Health, Ann Arbor, Michigan.

Background And Objectives: Immunosuppressive medications are critical for maintenance of graft function in transplant recipients but can represent a substantial financial burden to patients and their insurance carriers.

Design, Setting, Participants, & Measurements: To determine whether availability of generic immunosuppressive medications starting in 2009 may have alleviated some of that burden, we used Medicare Part D prescription drug events between 2008 and 2013 to estimate the average annualized per-patient payments made by patients and Medicare in a large national sample of kidney, liver, and heart transplant recipients. Repeated measures linear regression was used to determine changes in payments over the study period. Read More

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http://dx.doi.org/10.2215/CJN.10590918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419280PMC
March 2019
5 Reads

Stopping RAS Inhibitors to Minimize AKI: More Harm than Good?

Clin J Am Soc Nephrol 2019 Apr 27;14(4):617-619. Epub 2019 Feb 27.

London School of Hygiene and Tropical Medicine Non-Communicable Disease Epidemiology, London, United Kingdom.

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http://dx.doi.org/10.2215/CJN.14021118DOI Listing
April 2019
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