Clin J Am Soc Nephrol 2018 Jan 2. Epub 2018 Jan 2.
University of Rochester School of Medicine and Dentistry, Rochester General Hospital, Rochester, New York
Patients with severe (serum sodium ≤120 mEq/L), symptomatic hyponatremia can develop life-threatening or fatal complications from cerebral edema if treatment is inadequate and permanent neurologic disability from osmotic demyelination if treatment is excessive. Unfortunately, as is true of all electrolyte disturbances, there are no randomized trials to guide the treatment of this challenging disorder. Rather, therapeutic decisions rest on physiologic principles, animal models, observational studies, and single-patient reports. Read More