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    1473 results match your criteria Clinical Interventions in Aging[Journal]

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    Early postoperative delirium after hemiarthroplasty in elderly patients aged over 70 years with displaced femoral neck fracture.
    Clin Interv Aging 2017 6;12:1835-1842. Epub 2017 Nov 6.
    Department of Orthopaedic Surgery, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
    Purpose: Postoperative delirium is a risk factor for worse outcome after hip fracture surgery in elderly patients. Postoperative delirium is associated with anesthesia, postoperative pain, and patient factors. We investigated the incidence, predictors, and prognostic implications of post-operative delirium after hemiarthroplasty (HA) in elderly patients with femoral neck fracture. Read More

    Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration.
    Clin Interv Aging 2017 3;12:1829-1833. Epub 2017 Nov 3.
    Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece.
    Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment.

    Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter. Read More

    Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies.
    Clin Interv Aging 2017 30;12:1819-1828. Epub 2017 Oct 30.
    Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.
    Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting. Read More

    Geroprotectors as a therapeutic strategy for COPD - where are we now?
    Clin Interv Aging 2017 24;12:1811-1817. Epub 2017 Oct 24.
    Department of Pneumology and Allergy, 1st Chair of Internal Medicine.
    Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Read More

    Clostridium difficile infection in the elderly: an update on management.
    Clin Interv Aging 2017 24;12:1799-1809. Epub 2017 Oct 24.
    Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.
    The burden of Clostridium difficile infection (CDI) is profound and growing. CDI now represents a common cause of health care-associated diarrhea, and is associated with significant morbidity, mortality, and health care costs. CDI disproportionally affects the elderly, possibly explained by the following risk factors: age-related impairment of the immune system, increasing antibiotic utilization, and frequent health care exposure. Read More

    Functional outcomes by age after inpatient stroke rehabilitation in Saudi Arabia.
    Clin Interv Aging 2017 24;12:1791-1797. Epub 2017 Oct 24.
    Comprehensive Rehabilitation Care Department, Rehabilitation Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
    Background: Among various risk factors, age has been identified as a nonmodifiable risk factor for stroke that influences functional outcomes after inpatient stroke rehabilitation in the developed world as well as in Saudi Arabia (SA). The demand for inpatient stroke rehabilitation services increases with population aging and stroke incidence; however, these services are limited in SA.

    Objective: To examine functional outcomes by age after inpatient stroke rehabilitation in SA. Read More

    Psychosocial therapy for Parkinson's-related dementia: intervention development.
    Clin Interv Aging 2017 20;12:1779-1789. Epub 2017 Oct 20.
    Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
    Background: Group-based psychosocial therapy, such as group Cognitive Stimulation Therapy, improves cognition and quality of life in people living with dementia. Neuropsychiatric symptoms and restricted mobility are common complications for people with Parkinson's-related dementia (PRD) and may limit access to, and participation in, group activities. This study describes the development of a condition-specific, home-based psychosocial therapy for people with PRD ready to be trialled in a clinical population. Read More

    Inappropriate pharmacological treatment in older adults affected by cardiovascular disease and other chronic comorbidities: a systematic literature review to identify potentially inappropriate prescription indicators.
    Clin Interv Aging 2017 19;12:1761-1778. Epub 2017 Oct 19.
    Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
    Avoiding medications in which the risks outweigh the benefits in the elderly patient is a challenge for physicians, and different criteria to identify inappropriate prescription (IP) exist to aid prescribers. Definition of IP indicators in the Italian geriatric population affected by cardiovascular disease and chronic comorbidities could be extremely useful for prescribers and could offer advantages from a public health perspective. The purpose of the present study was to identify IP indicators by means of a systematic literature review coupled with consensus criteria. Read More

    Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women.
    Clin Interv Aging 2017 19;12:1753-1760. Epub 2017 Oct 19.
    Department of Geriatrics, Healthy Ageing Research Centre.
    Background: The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women.

    Subjects And Methods: Ninety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (Pmax) and optimal shortening velocity (υopt) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured. Read More

    Exploring the efficiency of the Tilburg Frailty Indicator: a review.
    Clin Interv Aging 2017 19;12:1739-1752. Epub 2017 Oct 19.
    Department of Methodology and Statistics, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, the Netherlands.
    Due to rapidly aging human populations, frailty has become an essential concept, as it identifies older people who have higher risk of adverse outcomes, such as disability, institutionalization, lower quality of life, and premature death. The Tilburg Frailty Indicator (TFI) is a user-friendly questionnaire based on a multidimensional approach to frailty, assessing physical, psychologic, and social aspects of human functioning. This review aims to explore the efficiency of the TFI in assessing frailty as a means to carry out research into the antecedents and consequences of frailty, and its use both in daily practice and for future intervention studies. Read More

    Bilingualism as a strategy to delay the onset of Alzheimer's disease.
    Clin Interv Aging 2017 19;12:1731-1737. Epub 2017 Oct 19.
    Biomedical Research Centre, University Hospital Hradec Kralove.
    The purpose of this study is to explore original studies which provide evidence about the effects of bilingualism on the delay of the onset of dementia, specifically Alzheimer's disease (AD). A literature review was conducted in the world's acknowledged databases: Web of Science, Scopus, and MEDLINE. Altogether, 14 original studies focusing on the research topic were detected. Read More

    Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS.
    Clin Interv Aging 2017 16;12:1725-1729. Epub 2017 Oct 16.
    Department of Emergency, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
    Objective: To examine the association between serum β2-microglobulin (B2M) levels and frailty in an elderly Chinese population.

    Design: A population-based cohort study.

    Setting And Participants: We used data on 1,663 elderly participants (aged 70-84 years) from the aging arm of the Rugao Longevity and Ageing study, a population-based observational two-arm cohort study conducted in Rugao, China. Read More

    Evaluation of various equations for estimating renal function in elderly Chinese patients with type 2 diabetes mellitus.
    Clin Interv Aging 2017 9;12:1661-1672. Epub 2017 Oct 9.
    The Fifth People's Hospital of Shanghai, Fudan University.
    Background: The clinical assessment of kidney function based on the estimated glomerular filtration rate (GFR) in older patients remains controversial. This study evaluated the concordance and feasibility of using various creatinine-based equations for estimating GFR in elderly Chinese patients with type 2 diabetes mellitus (T2DM).

    Methods: A cross-sectional analytical study was conducted in 21,723 older diabetic patients (≥60 years) based on electronic health records (EHR) for Minhang District, Shanghai, China. Read More

    The incidence of depression among residents of assisted living: prevalence and related risk factors.
    Clin Interv Aging 2017 9;12:1645-1653. Epub 2017 Oct 9.
    Department of Nursing, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
    Aim: This study aims to recognize and estimate the prevalence of depression and its risk factors among residents of assisted living facilities (ALs) in Jordan.

    Background: Depression is commonly experienced by residents of ALs. The condition is, however, often misunderstood as a part of normal aging and may be overlooked by health care professionals. Read More

    Odor selectivity of hyposmia and cognitive impairment in patients with Parkinson's disease.
    Clin Interv Aging 2017 9;12:1637-1644. Epub 2017 Oct 9.
    Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University.
    Objective: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. Read More

    Response to teriparatide in Chinese patients with established osteoporosis: osteocalcin and lumbar spine bone-mineral density changes from teriparatide Phase III study.
    Clin Interv Aging 2017 12;12:1717-1723. Epub 2017 Oct 12.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
    Teriparatide is the first anabolic agent for osteoporosis, and this analysis aimed to understand responses to teriparatide in Chinese patients with established osteoporosis in subgroups. In this Phase III study of teriparatide in China, 362 patients were randomized at a 2:1 ratio to receive subcutaneous teriparatide (20 μg/day) or intranasal salmon calcitonin (200 IU/day) for 24 weeks. Teriparatide treatment produced a significantly greater increase in lumbar spine bone-mineral density (LS-BMD) in postmenopausal women than calcitonin at the 24-week end point. Read More

    Comparative study of two different respiratory training protocols in elderly patients with chronic obstructive pulmonary disease.
    Clin Interv Aging 2017 12;12:1705-1715. Epub 2017 Oct 12.
    Physical Therapy Department for Internal Medicine.
    Aim: The aim of the present study was to compare threshold inspiratory muscle training (IMT) and expiratory muscle training (EMT) in elderly male patients with moderate degree of COPD.

    Materials And Methods: Forty male patients with moderate degree of COPD were recruited for this study. They were randomly divided into two groups: the IMT group who received inspiratory training with an intensity ranging from 15% to 60% of their maximal inspiratory pressure, and the EMT group who received expiratory training with an equal intensity which was adjusted according to the maximal expiratory pressure. Read More

    Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria.
    Clin Interv Aging 2017 12;12:1697-1703. Epub 2017 Oct 12.
    Department of Geriatrics.
    Aim: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. The purpose of the study was to investigate the prevalence of PIMs identified by the Beers 2015 and 2012 criteria in older patients in China and identify the correlates of PIMs.

    Methods: This retrospective, cross-sectional study was conducted at Peking University First Hospital. Read More

    Optimization of drug therapy in elderly individuals admitted to a geriatric unit.
    Clin Interv Aging 2017 11;12:1691-1696. Epub 2017 Oct 11.
    Gérontopôle, Centre Hospitalier Universitaire Toulouse, Toulouse, France.
    Background: A substantial share of adverse drug events involves inappropriate prescribing (IP). Specialized geriatric units are supposed to pay particular attention to prescribing appropriateness and to promoting a higher prescribing quality.

    Objective: The objective of this study was to evaluate the reality of such assessment and optimization in real life (usual care) in a population of elderly individuals admitted to a geriatric unit. Read More

    Application of a computer-based neurocognitive assessment battery in the elderly with and without hearing loss.
    Clin Interv Aging 2017 11;12:1681-1690. Epub 2017 Oct 11.
    Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St Elisabeth-Hospital, Bochum.
    Introduction: Due to demographic changes, the number of people suffering not only from dementia illness but also from hearing impairment with the need for hearing rehabilitation have increased noticeably. Even with the association between hearing, age, and cognitive decline being well known, this issue has so far not played an important role in daily clinical Ear Nose Throat settings. The aim of the present study was to evaluate the use of a computer-based battery of tests of neurocognitive abilities in older patients with and without hearing loss. Read More

    Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China.
    Clin Interv Aging 2017 10;12:1673-1679. Epub 2017 Oct 10.
    Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics.
    Background: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China. Read More

    REAC regenerative treatment efficacy in experimental chondral lesions: a pilot study on ovine animal model.
    Clin Interv Aging 2017 14;12:1471-1479. Epub 2017 Sep 14.
    Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy.
    Radioelectric asymmetric conveyor (REAC) technology is a platform designed to optimize cell polarity. Cell polarity is a universal biological phenomenon that is implicated in cell differentiation, proliferation, morphogenesis, aging, and rejuvenation. In this work, we investigate a timing and administration protocol for tissue optimization regenerative treatment type C, in order to treat aging-related chondral damage or injuries and gain insights into regenerative processes of articular cartilage in humans. Read More

    Spectrum of noncerebrovascular rapidly progressive cognitive deterioration: a 2-year retrospective study.
    Clin Interv Aging 2017 9;12:1655-1659. Epub 2017 Oct 9.
    Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
    Purpose: The number of cognitive deterioration patients has been steadily increasing as the population ages in China. Patients with cognitive deterioration demonstrated diverse patterns, often making the diagnosis difficult, especially in rapidly progressive cognitive deterioration (RPCD) patients. The purpose of this study was to exhibit the disease spectrum and frequency of noncerebrovascular RPCD in patients from a medical college hospital of southeastern China. Read More

    Quality of life and physical activity in an older working-age population.
    Clin Interv Aging 2017 4;12:1627-1634. Epub 2017 Oct 4.
    Faculty of Physical Education, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
    Objective: Physical activity can be an effective means of prevention and therapy of many psychosomatic disorders. It can also have a significant impact on the quality of life of older working-age people. The aim of the present study was to assess the relationships between quality of life and physical activity in older working-age people from Wrocław, Poland. Read More

    Assessing the nutritional status of hospitalized elderly.
    Clin Interv Aging 2017 4;12:1615-1625. Epub 2017 Oct 4.
    Department of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Malaysia.
    Purpose: The increasing number of elderly people worldwide throughout the years is concerning due to the health problems often faced by this population. This review aims to summarize the nutritional status among hospitalized elderly and the role of the nutritional assessment tools in this issue.

    Methods: A literature search was performed on six databases using the terms "malnutrition", "hospitalised elderly", "nutritional assessment", "Mini Nutritional Assessment (MNA)", "Geriatric Nutrition Risk Index (GNRI)", and "Subjective Global Assessment (SGA)". Read More

    Understanding institutional stakeholders' perspectives on multidrug-resistant bacterial organism at the end of life: a qualitative study.
    Clin Interv Aging 2017 3;12:1605-1613. Epub 2017 Oct 3.
    Department of Palliative Medicine, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Bavaria, Germany.
    Background: Information lacks about institutional stakeholders' perspectives on management approaches of multidrug-resistant bacterial organism in end-of-life situations. The term "institutional stakeholder" includes persons in leading positions with responsibility in hospitals' multidrug-resistant bacterial organism management. They have great influence on how strategies on multidrug-resistant bacterial organism management approaches in institutions of the public health system are designed. Read More

    A scoping review of crisis teams managing dementia in older people.
    Clin Interv Aging 2017 3;12:1589-1603. Epub 2017 Oct 3.
    Institute of Mental Health, University of Nottingham, Nottingham, UK.
    Background: Research on crisis teams for older adults with dementia is limited. This scoping review aimed to 1) conduct a systematic literature review reporting on the effectiveness of crisis interventions for older people with dementia and 2) conduct a scoping survey with dementia crisis teams mapping services across England to understand operational procedures and identify what is currently occurring in practice.

    Methods: For the systematic literature review, included studies were graded using the Critical Appraisal Skills Programme checklist. Read More

    Early and intermediate age-related macular degeneration: update and clinical review.
    Clin Interv Aging 2017 3;12:1579-1587. Epub 2017 Oct 3.
    Red Telemática de Investigación Cooperativa Oftared, Instituto de Salud Carlos III, Madrid, Spain.
    Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries. With the aging of population, AMD will become globally an increasingly important and prevalent disease worldwide. It is a complex disease whose etiology is associated with both genetic and environmental risk factors. Read More

    Prescribing of psychotropic medication for nursing home residents with dementia: a general practitioner survey.
    Clin Interv Aging 2017 3;12:1573-1578. Epub 2017 Oct 3.
    School of Medicine, Faculty of Health, University of Tasmania, Hobart, TAS, Australia.
    Objective: The aim of this study was to identify factors influencing the prescribing of psychotropic medication by general practitioners (GPs) to nursing home residents with dementia.

    Subjects And Methods: GPs with experience in nursing homes were recruited through professional body newsletter advertising, while 1,000 randomly selected GPs from southeastern Australia were invited to participate, along with a targeted group of GPs in Tasmania. An anonymous survey was used to collect GPs' opinions. Read More

    Cognitive deficits and self-care behaviors in elderly adults with heart failure.
    Clin Interv Aging 2017 3;12:1565-1572. Epub 2017 Oct 3.
    Department of Physiological Nursing, School of Nursing.
    Introduction: Elderly adults with heart failure (HF) may have problems with self-care behaviors because of cognitive deficits. Self-care deficits have been found to be significantly associated with negative health care outcomes among HF patients. The aim of this paper was to assess cognitive deficits and the level of self-care ability in elderly patients with HF, and to determine if a relationship exists between cognitive deficits and self-care. Read More

    Pressure injuries in elderly with acute myocardial infarction.
    Clin Interv Aging 2017 19;12:1495-1501. Epub 2017 Sep 19.
    Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
    Objectives: To assess pressure injury (PI) incidence among patients hospitalized for acute myocardial infarction (AMI) in an intensive coronary care unit (ICCU) and to detect the impact of specific risk factors on the development of PI in this clinical setting.

    Patients And Methods: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67. Read More

    Assessing capacity to consent for research in cognitively impaired older patients.
    Clin Interv Aging 2017 26;12:1553-1563. Epub 2017 Sep 26.
    Geriatric Department, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
    Background: The number of clinical trials including older patients, and particularly patients with cognitive impairment, is increasing. While statutory provisions exist to make sure that the capacity to consent is assessed systematically for each patient, many gray areas remain with regard to how this assessment is made or should be made in the routine practice of clinical research.

    Objectives: The aim of this review was to draw up an inventory of assessment tools evaluating older patients' capacity to consent specifically applicable to clinical research, which could be used in routine practice. Read More

    The effects of holistic health group interventions on improving the cognitive ability of persons with mild cognitive impairment: a randomized controlled trial.
    Clin Interv Aging 2017 25;12:1543-1552. Epub 2017 Sep 25.
    Department of Social Work, Hong Kong Baptist University, Kowloon Tong.
    Purpose: Persons with mild cognitive impairment (PwMCI) are at a higher risk of developing dementia than those without cognitive impairment. This research study aims to evaluate the effectiveness of a holistic health group intervention, which is based on the holistic brain health approach as well as an Eastern approach to health care, on improving the cognitive ability of Chinese PwMCI.

    Research Methods: In a randomized controlled trial (RCT), 38 Chinese PwMCI were randomly assigned to either a 10-session holistic health intervention group or the control group. Read More

    Psychometric properties of the Farsi version of Attitudes to Aging Questionnaire in Iranian older adults.
    Clin Interv Aging 2017 22;12:1531-1542. Epub 2017 Sep 22.
    Faculty of Nursing and Midwifery, Shahed University, Tehran, Iran.
    Background: Attitudes to the aging process are affected by the individual's sociocultural background. The measurement of this important concept among older people in various societies requires the use of tools that are able to demonstrate both reliability and validity.

    Objective: The objectives of this study were to translate and validate the Attitudes to Aging Questionnaire (AAQ) and investigate its psychometric features among Iranian older people. Read More

    Mindfulness training for psychological stress in family caregivers of persons with dementia: a systematic review and meta-analysis of randomized controlled trials.
    Clin Interv Aging 2017 22;12:1521-1529. Epub 2017 Sep 22.
    The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
    Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-analytic review. We searched randomized controlled trials (RCT) through April 2017 from five electronic databases, and assessed the risk of bias using the Cochrane Collaboration tool. Read More

    Can we predict postoperative complications in elderly Chinese patients with hip fractures using the surgical risk calculator?
    Clin Interv Aging 2017 22;12:1515-1520. Epub 2017 Sep 22.
    Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
    Purpose: Hip fractures are associated with poor prognosis in elderly patients partly due to the high rate of postoperative complications. This study was aimed to investigate whether the surgical risk calculator is suitable for predicting postoperative complications in elderly Chinese patients with hip fractures.

    Methods: The incidence of postoperative complications among 410 elderly patients with hip fractures was predicted by the surgical risk calculator and then compared with the actual value. Read More

    Whole-body electromyostimulation and protein supplementation favorably affect sarcopenic obesity in community-dwelling older men at risk: the randomized controlled FranSO study.
    Clin Interv Aging 2017 21;12:1503-1513. Epub 2017 Sep 21.
    Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
    Background: Sarcopenic obesity (SO) is a geriatric syndrome characterized by the disproportion between the amount of lean mass and fat mass. Exercise decreases fat and maintains muscle mass; however, older people fail to exercise at doses sufficient to affect musculoskeletal and cardiometabolic risk factors. The aim of this study was to evaluate the effect of whole-body electromyostimulation (WB-EMS), a time-efficient, joint-friendly and highly individualized exercise technology, on sarcopenia and SO in older men. Read More

    Alveolar ridge atrophy related to facial morphology in edentulous patients.
    Clin Interv Aging 2017 13;12:1481-1494. Epub 2017 Sep 13.
    Department of Prosthodontics.
    Objectives: The morphology of the alveolar process determines the retention and stability of prosthetic restorations, thereby determining the result of the therapy. Considering that the edentulous jaws may be affected by the atrophy process, it was hypothesized that the morphology of the alveolar process of the maxilla may be dependent on the anterior facial height and anatomy of the mandible.

    Subjects And Methods: Twenty-five healthy edentulous Caucasian individuals were randomly chosen. Read More

    Feasibility and first results of a group program to increase the frequency of cognitively stimulating leisure activities in people with mild cognitive impairment (AKTIVA-MCI).
    Clin Interv Aging 2017 12;12:1459-1469. Epub 2017 Sep 12.
    Geriatric Medicine, Institute of General Practice, Goethe University, Frankfurt, Germany.
    AKTIVA-MCI is a program for patients with mild cognitive impairment (MCI) that aims to enhance participation in cognitively stimulating leisure activities. Participation in cognitively stimulating activities seems to be a potential strategy for people with MCI delaying cognitive decline for a while. In total, 35 MCI patients were enrolled in the pilot study of whom 29 completed the whole program (16 female, 71. Read More

    Cognitive impairment associated with locomotive syndrome in community-dwelling elderly women in Japan.
    Clin Interv Aging 2017 12;12:1451-1457. Epub 2017 Sep 12.
    Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
    In our worldwide aging society, elderly people should maintain cognitive and physical function to help avoid health problems. Dementia is a major brain disease among elderly people, and is caused by cognitive impairment. The locomotive syndrome (LS) refers to a condition in which people require healthcare services because of problems associated with locomotion. Read More

    Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus.
    Clin Interv Aging 2017 15;12:1443-1450. Epub 2017 Sep 15.
    Universidade Federal de Sergipe (UFS), São Cristóvão, Sergipe.
    Type 2 diabetes mellitus (T2DM) consists of a set of metabolic and endocrine disorders which evolve into deficiency in insulin action and hyperglycemia. Physical exercise is considered the main intervention to prevent and control T2DM. Literature has suggested that circulating microRNAs (miRs) help to understand responses to physical activity among diabetic patients. Read More

    Evaluation on the implementation of respiratory protection measures in old age homes.
    Clin Interv Aging 2017 11;12:1429-1438. Epub 2017 Sep 11.
    Sau Po Centre on Ageing, The University of Hong Kong, Pok Fu Lam, Hong Kong.
    Purpose: Old age homes (OAHs) represent a vulnerable community for influenza outbreaks. Effective implementation of respiratory protection measures has been identified as an effective prevention measure to reduce mortality and morbidity caused by such outbreaks. Yet, relatively little is known about this aspect in these homes. Read More

    Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.
    Clin Interv Aging 2017 8;12:1419-1428. Epub 2017 Sep 8.
    Charles Perkins Centre, University of Sydney, Sydney.
    Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Read More

    Five-year durability of stand-alone interspinous process decompression for lumbar spinal stenosis.
    Clin Interv Aging 2017 6;12:1409-1417. Epub 2017 Sep 6.
    Independent Consultant, Chicago, IL, USA.
    Background: Lumbar spinal stenosis is the most common indication for spine surgery in older adults. Interspinous process decompression (IPD) using a stand-alone spacer that functions as an extension blocker offers a minimally invasive treatment option for intermittent neurogenic claudication associated with spinal stenosis.

    Methods: This study evaluated the 5-year clinical outcomes for IPD (Superion(®)) from a randomized controlled US Food and Drug Administration (FDA) noninferiority trial. Read More

    Gene expression levels of the insulin-like growth factor family in patients with AMD before and after ranibizumab intravitreal injections.
    Clin Interv Aging 2017 5;12:1401-1408. Epub 2017 Sep 5.
    Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
    Purpose: The present study focused on the assessment of the mRNA levels of the insulin-like growth factor (IGF) family in patients with the exudative form of age-related macular degeneration (AMD) before and after ranibizumab intravitreal injections.

    Patients And Methods: An analysis of the expression profile of the IGF family of genes in patients with AMD was carried out using the oligonucleotide microarray and quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) methods.

    Results: In the peripheral blood mononuclear cells (PBMCs) obtained from AMD group receiving ranibizumab compared to the peripheral blood mononuclear cells from AMD group before ranibizumab treatment using oligonucleotide microarray technique, six statistically significant differentially expressed transcripts related to the IGF family were detected (unpaired t-test, p<0. Read More

    Correlations between satisfaction with life and selected personal resources among students of Universities of the Third Age.
    Clin Interv Aging 2017 31;12:1391-1399. Epub 2017 Aug 31.
    Department of Pedagogy and Nursing Didactics, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.
    Purpose: The aim of the study was to identify personal resources, including health-related resources, sense of self-efficacy, attitude to life (optimism/pessimism) and self-assessment, and to determine their relationship with satisfaction with life in members of the Universities of the Third Age (U3As) in Poland. The impact of sociodemographic factors was analyzed.

    Materials And Methods: The study included 320 participants of U3As; their mean age was 67. Read More

    Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol.
    Clin Interv Aging 2017 30;12:1379-1389. Epub 2017 Aug 30.
    Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium.
    Background: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. Read More

    Analysis of the dynamics of venous blood flow in the context of lower limb temperature distribution and tissue composition in the elderly.
    Clin Interv Aging 2017 28;12:1371-1378. Epub 2017 Aug 28.
    Department of Physiotherapy and Occupational Therapy in Conservative and Interventional Medicine, University of Physical Education in Wroclaw, Wroclaw, Poland.
    Objective: The elderly are particularly vulnerable to degenerative diseases, such as circulatory and respiratory system and vascular system diseases. The objective of this study was therefore to evaluate the distribution of temperature and the dynamics of venous blood flow in the lower limbs (LLs) and to assess the interdependence of these parameters in terms of the somatic components in males and females participating in activities at the University of the Third Age.

    Materials And Methods: The study included 60 females (mean age 67. Read More

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