1,621 results match your criteria Clinical Interventions in Aging[Journal]


Sarcopenic obesity and cognitive performance.

Clin Interv Aging 2018 6;13:1111-1119. Epub 2018 Jun 6.

Charles E. Schmidt College of Medicine, Department of Integrated Medical Sciences, Comprehensive Center for Brain Health, Florida Atlantic University, Boca Raton, FL, USA.

Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Read More

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Risk evaluation of new-onset atrial fibrillation complicating ST-segment elevation myocardial infarction: a comparison between GRACE and CHADS-VASc scores.

Clin Interv Aging 2018 6;13:1099-1109. Epub 2018 Jun 6.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Purpose: New-onset atrial fibrillation (NOAF) is a common finding in patients with myocardial infarction (MI), but few studies are available regarding the prediction model for its risk estimation. Although Global Registry of Acute Coronary Events (GRACE) risk score (RS) has been recognized as an effective tool for the risk evaluation of clinical outcomes in patients with MI, its usefulness in the prediction of post-MI NOAF remains unclear. In this study, we sought to validate the discrimination performance of GRACE RS in the prediction of post-MI NOAF and to make a comparison with that of the CHADS-VASc score in patients with ST-segment elevation myocardial infarction (STEMI). Read More

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June 2018
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Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes.

Clin Interv Aging 2018 6;13:1091-1098. Epub 2018 Jun 6.

Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.

Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated.

Materials And Methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study. Read More

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Usual gait speed is associated with frailty status, institutionalization, and mortality in community-dwelling rural older adults: a longitudinal analysis of the Aging Study of Pyeongchang Rural Area.

Clin Interv Aging 2018 6;13:1079-1089. Epub 2018 Jun 6.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Purpose: We aimed to describe the age- and sex-specific distributions of gait speed and to evaluate associations with longitudinal outcomes in Korean rural community-dwelling older adults.

Patients And Methods: A total of 1,348 people (mean age: 76 years, 55% women) in the population-based, prospective cohort of Aging Study of Pyeongchang Rural Area (ASPRA) between October 2014 and June 2017. All participants underwent a comprehensive geriatric assessment, including 4-m usual gait speed, and were followed annually. Read More

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Pilot study to examine the effects of indoor daylight exposure on depression and other neuropsychiatric symptoms in people living with dementia in long-term care communities.

Clin Interv Aging 2018 30;13:1071-1077. Epub 2018 May 30.

Leonard Davis School of Gerontology.

A 12-week study was conducted in eight dementia care communities involving 77 participants addressing the hypothesis that an intervention of increasing indoor exposure to daylight will reduce depression and other neuropsychiatric symptoms. At four communities, staff were enlisted to increase daylight exposure by taking participants to a perimeter room with daylight exposure for socialization in the morning (8:00-10:00 AM) each day. At the other four communities, a control group were taken to a similar sized area without daylight for socialization under typical electrical lighting conditions. Read More

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May 2018
2 Reads

Early delirium after cardiac surgery: an analysis of incidence and risk factors in elderly (≥65 years) and very elderly (≥80 years) patients.

Clin Interv Aging 2018 30;13:1061-1070. Epub 2018 May 30.

Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, Szczecin, Poland.

Introduction: Postoperative delirium is a common complication of cardiac surgery associated with increased mortality, morbidity, and long-term cognitive dysfunction. The aim of this study was to identify incidence and risk factors of delirium in elderly (≥65 years) and very elderly (≥80 years) patients undergoing major cardiac surgery.

Materials And Methods: We performed a retrospective cohort analysis of prospectively collected data from a register of the cardiac surgery department of a tertiary referral university hospital between 2014 and 2016. Read More

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May 2018
2 Reads

Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy.

Clin Interv Aging 2018 30;13:1053-1060. Epub 2018 May 30.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Remifentanil infusion during emergence lowers cough. Effect-site concentration (Ce) of remifentanil using target-controlled infusion (TCI) has been evaluated in previous studies. Recent studies revealed the existence of sex-related differences in remifentanil Ce in young and elderly patients. Read More

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May 2018
2 Reads

Pain as a challenge in nursing home residents with behavioral and psychological symptoms of dementia.

Clin Interv Aging 2018 25;13:1045-1051. Epub 2018 May 25.

Laboratory of Geriatrics, Department of Palliative Medicine, Poznan University of Medical Sciences, Poznań, Poland.

Introduction: In patients with dementia, observational scales are recommended for use in the assessment of pain. Unfortunately, their application is rare, and as a consequence pain is frequently underdiagnosed and undertreated in these types of subjects. Thus, the aim of the study was to assess analgesic treatment in nursing home residents with cognitive impairment and to delineate the relationship between pain and behavioral and psychological symptoms of dementia. Read More

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May 2018
2 Reads

Erratum: Frequency of frailty and its association with cognitive status and survival in older Chileans [Corrigendum].

Authors:

Clin Interv Aging 2018 25;13:1043. Epub 2018 May 25.

[This corrects the article on p. 995 in vol. 12, PMID: 28721027. Read More

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May 2018
2 Reads

Combined use of drugs inhibiting the renin-angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents.

Clin Interv Aging 2018 25;13:1035-1042. Epub 2018 May 25.

Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background/aims: In 2012, the European Medicines Agency reviewed the safety of dual renin-angiotensin system (RAS) blockade because of potentially increased risks for inter alia acute kidney injury (AKI). Since residents of nursing homes are particularly vulnerable to adverse drug outcomes, the aims of our study were to describe RAS-inhibiting drug use in German nursing home residents and examine the risk of AKI associated with dual RAS blockade.

Methods: Based on claims data, a nested case-control study within a cohort of RAS-inhibiting drug users was conducted. Read More

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May 2018
2 Reads

Comprehensive geriatric intervention program with and without weekly class-style exercise: research protocol of a cluster randomized controlled trial in Kyoto-Kameoka Study.

Clin Interv Aging 2018 24;13:1019-1033. Epub 2018 May 24.

Laboratory of Applied Health Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objective: The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program (CGIP) for restraints of LTC users and the associated expenditures in the future. Read More

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May 2018
3 Reads

Fat infiltration in the gluteus minimus muscle in older adults.

Clin Interv Aging 2018 23;13:1011-1017. Epub 2018 May 23.

Graduate School of Health Science, Yamagata Prefectural University of Health Science, Yamagata, Japan.

Purpose: Fat infiltration (FI) in the gluteus minimus muscle (GMin) has been reported as being restricted to the anterior part. The aim of this study was to verify whether FI is localized only to the anterior part of the GMin through the dissection of large number of elderly cadavers and to clarify the underlying mechanism of FI localized to a specific region.

Materials And Methods: Thirty-eight hips from 20 embalmed elder cadavers were dissected for verification of FI localization. Read More

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May 2018
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Management of AO type 12C humerus proximal metadiaphyseal fractures with minimally invasive plate osteosynthesis in geriatric patients.

Clin Interv Aging 2018 22;13:1003-1010. Epub 2018 May 22.

Orthopaedics and Traumatology Department, Adana Numune Training and Research Hospital, Adana, Turkey.

Background: To evaluate the treatment efficacy and complications of the lateral minimally invasive plate osteosynthesis (MIPO) method in geriatric patients with a humerus diaphyseal fracture with proximal extension.

Patients And Methods: The study included a total of 21 patients (18 females, 3 males; mean age 74±6.3 years, range 65-89 years) who underwent surgery with the lateral MIPO technique for a humerus diaphyseal fracture with proximal extension during the period January 2011 to December 2016. Read More

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May 2018
6 Reads

Improvement of decision-making criteria for the care of elderly cancer patients by general practitioners (Lorraine, France).

Clin Interv Aging 2018 21;13:995-1002. Epub 2018 May 21.

Department of Geriatric Medicine, CHRU de Nancy, Nancy, France.

Objective: The objective of this study was to identify changes in the decision-making criteria of general practitioners (GPs) concerning the care of elderly cancer patients after 1 year of corrective measures for care practices in the Lorraine region, France.

Materials And Methods: In 2014, a postal mail questionnaire was sent to all GPs in the Lorraine region. This questionnaire was designed to identify GPs' decision-making criteria. Read More

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May 2018
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Age-related changes in shock absorption capacity of the human spinal column.

Clin Interv Aging 2018 18;13:987-993. Epub 2018 May 18.

Faculty of Physical Education and Physiotherapy, Institute of Physiotherapy, Opole University of Technology, Opole, Poland.

Background: The spinal column possesses shock absorption properties, mainly provided by the intervertebral discs. However, with the process of senescence, all structures of the spine, including the discs, undergo degenerative changes. It may lead to alteration of the mechanical properties of the spinal motion segment and diminished capacity for vibration attenuation. Read More

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May 2018
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Development and validation of the Medication Regimen Simplification Guide for Residential Aged CarE (MRS GRACE).

Clin Interv Aging 2018 18;13:975-986. Epub 2018 May 18.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

Background: Residents of aged care facilities use increasingly complex medication regimens. Reducing unnecessary medication regimen complexity (eg, by consolidating the number of administration times or using alternative formulations) may benefit residents and staff.

Objective: To develop and validate an implicit tool to facilitate medication regimen simplification in aged care facilities. Read More

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May 2018
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Sensory and memory stimulation as a means to care for individuals with dementia in long-term care facilities.

Clin Interv Aging 2018 17;13:967-974. Epub 2018 May 17.

School of Health Administration, Texas State University, San Marcos, TX, USA.

Objective: The primary objective of this study was to identify and further examine the facilitators and barriers of utilizing sensory and memory stimulation as a means to care for individuals with dementia who live in long-term care settings.

Materials And Methods: The authors conducted a literature review of 30 academic articles found using the databases such as CINAHL, PubMed, and Academic Search Ultimate from the past 15 years. Facilitator and barrier themes were found within each article and analyzed for their relevance to sensory and memory stimulation therapies and their effects on individuals with dementia. Read More

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May 2018
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The impact of pelvic floor muscle training on the quality of life of women with urinary incontinence: a systematic literature review.

Clin Interv Aging 2018 17;13:957-965. Epub 2018 May 17.

Department of Physiotherapy, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Purpose: The purpose of this review was to assess the effectiveness of pelvic floor muscle training (PFMT) in the treatment of urinary incontinence (UI) in women, with a particular focus on the impact of this form of therapy on the patients' quality of life (QoL).

Methods: The following electronic databases were searched: PubMed, Embase, and Cochrane Library (articles only in English, 1990-2017). Search terms were as follows: urinary incontinence, pelvic floor muscle training, pelvic floor exercises, quality of life. Read More

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Frailty transitions and types of death in Chinese older adults: a population-based cohort study.

Clin Interv Aging 2018 16;13:947-956. Epub 2018 May 16.

Department of Intensive Care Unit, Xuyi People's Hospital, Xuyi, China.

Background: Little is known about the adverse effects of frailty transitions. In this study, we aimed to characterize the transitions between frailty states and examine their associations with the type of death among older adults in China, a developing country with a rapidly growing aging population.

Methods: We used data of 11,165 older adults (aged 65-99 years) from the 2002 and 2005 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Read More

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Tolerability of buprenorphine transdermal system in nursing home patients with advanced dementia: a randomized, placebo-controlled trial (DEP.PAIN.DEM).

Clin Interv Aging 2018 16;13:935-946. Epub 2018 May 16.

Department of Global Public Health and Primary Care, Centre for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway.

Purpose: Buprenorphine transdermal system is increasingly prescribed in people with advanced dementia, but no clinical trial has investigated the safety and factors associated with discontinuation due to adverse events in this population.

Patients And Methods: One hundred sixty-two people with advanced dementia and significant depression from 47 nursing homes were included and randomized to active analgesic treatment (acetaminophen/buprenorphine) or identical placebo for 13 weeks. In this secondary analysis, the main outcomes were time to and reasons for discontinuation of buprenorphine due to adverse events. Read More

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Comparison of the effectiveness of complex decongestive therapy and compression bandaging as a method of treatment of lymphedema in the elderly.

Clin Interv Aging 2018 14;13:929-934. Epub 2018 May 14.

Department of Geriatric Medicine and Gerontology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland.

Background: Lymphedema is a chronic condition which significantly lowers the quality of patient life, particularly among elderly populations, whose mobility and physical function are often reduced.

Objectives: The aim of the study was to compare the effectiveness of multi-layer compression bandaging (MCB) and complex decongestive therapy (CDT), and to show that MCB is a cheaper, more accessible and less labor intensive method of treating lymphedema in elderly patients.

Patients And Methods: The study included 103 patients (85 women and 18 men) aged ≥60 years, with unilateral lower limb lymphedema. Read More

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May 2018
2 Reads

Sarcopenia: assessment of disease burden and strategies to improve outcomes.

Clin Interv Aging 2018 14;13:913-927. Epub 2018 May 14.

Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.

Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength - a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors - in particular, nutritional status and degree of physical activity. Read More

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May 2018
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Inter-gender differences of balance indicators in persons 60-90 years of age.

Clin Interv Aging 2018 11;13:903-912. Epub 2018 May 11.

Faculty of Medicine and Health Sciences, Institute of Physiotherapy, The Jan Kochanowski University, Kielce, Poland.

Introduction: Precision of movements responsible for maintaining balance deteriorates with age due to natural involutionary processes, thus prompting a research question whether the values of gender-related stability indicators might differ significantly among the study subjects over 60 years of age.

Methods: The study group comprised 136 seniors (89 women, 47 men; aged 60-90 years). The CQ-Stab 2P 2-platform posturograph was used as the main research device, whereas the Mann-Whitney -test was used to evaluate the gender-related differences in the average level of variables. Read More

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May 2018
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Effect of starting oral intake on weekends on the clinical course of patients with aspiration pneumonia.

Clin Interv Aging 2018 9;13:895-901. Epub 2018 May 9.

Division of Community Medicine and Medical Education, Kobe University Graduate School of Medicine, Kobe, Japan.

Purpose: The aim of this study was to investigate whether the day of starting oral intake affects the clinical course of patients with aspiration pneumonia.

Results: We conducted a retrospective cohort study of 392 patients who were hospitalized for aspiration pneumonia but tolerated oral intake. Patients were divided into two groups according to the day of starting oral intake: Monday to Friday (midweek group) and Saturday or Sunday (weekend group). Read More

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May 2018
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Utility of the Care Dependency Scale in predicting care needs and health risks of elderly patients admitted to a geriatric unit: a cross-sectional study of 200 consecutive patients.

Clin Interv Aging 2018 8;13:887-894. Epub 2018 May 8.

Department and Clinic of Geriatrics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Objective: The aim of the study was to evaluate the usefulness of the Polish version of the Care Dependency Scale (CDS) in predicting care needs and health risks of elderly patients admitted to a geriatric unit.

Methods: This was a cross-sectional study of 200 geriatric patients aged ≥60 years, chronologically admitted to a geriatrics unit in Poland. The study was carried out using the Polish version of the CDS questionnaire to evaluate biopsychosocial needs and the level of care dependency. Read More

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May 2018
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Usability and acceptability of technology for community-dwelling older adults with mild cognitive impairment and dementia: a systematic literature review.

Clin Interv Aging 2018 4;13:863-886. Epub 2018 May 4.

Faculty of Health, Oslo Metropolitan University, Oslo, Norway.

Background: The objective of this review was to obtain an overview of the technologies that have been explored with older adults with mild cognitive impairment and dementia (MCI/D), current knowledge on the usability and acceptability of such technologies, and how people with MCI/D and their family carers (FCs) were involved in these studies.

Materials And Methods: Primary studies published between 2007 and 2017 that explored the use of technologies for community-dwelling people with MCI/D were identified through five databases: MEDLINE, PsycINFO, Embase, AMED, and CINAHL. Twenty-nine out of 359 papers met the criteria for eligibility. Read More

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May 2018
2 Reads

Percutaneous kyphoplasty combined with zoledronic acid infusion in the treatment of osteoporotic thoracolumbar fractures in the elderly.

Clin Interv Aging 2018 4;13:853-861. Epub 2018 May 4.

Department of Trauma Surgery, Wuhan No 1 Hospital, Wuhan, China.

Objective: We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OVCFs]).

Materials And Methods: We retrospectively analyzed 95 elderly patients (age >65 years) with OVCF. All patients were followed up for 2 years. Read More

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May 2018
3 Reads

Using the Frailty Assessment for Care Planning Tool (FACT) to screen elderly chronic kidney disease patients for frailty: the nurse experience.

Clin Interv Aging 2018 7;13:843-852. Epub 2018 May 7.

Dalhousie University, Halifax, NS, Canada.

Purpose: Recent evidence supports the prognostic significance of frailty for functional decline and poor health outcomes in patients with chronic kidney disease. Yet, despite the development of clinical tools to screen for frailty, little is known about the experiential impact of screening for frailty in this setting. The Frailty Assessment for Care Planning Tool (FACT) evaluates frailty across 4 domains: mobility, function, social circumstances, and cognition. Read More

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May 2018
1 Read

Metabolomics study of the therapeutic mechanism of lignans on aging rats induced by d-galactose.

Clin Interv Aging 2018 1;13:829-841. Epub 2018 May 1.

Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, People's Republic of China.

Objective: The aim of this study was to evaluate the antiaging effect of lignans (SCL) by analyzing the characteristics in the serum of d-galactose (d-gal)-induced rats.

Methods: Forty male Wistar rats were randomly divided into control group, d-gal model group, low-dose SCL group (50 mg/kg/d), medium-dose SCL group (100 mg/kg/d), and high-dose SCL group (200 mg/kg/d). A serum metabolomics analysis method based on rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry was carried out to study the characteristics of d-gal-induced aging rats and evaluate the antiaging effects of SCL, and multivariate statistical analysis was performed for pattern recognition and characteristic metabolites identification. Read More

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May 2018
1 Read

Locomotive syndrome: clinical perspectives.

Clin Interv Aging 2018 30;13:819-827. Epub 2018 Apr 30.

Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Yazako Karimata, Nagakute, Aichi, Japan.

The deterioration of locomotive components, which comprise bones, joints, and intervertebral discs, and muscles and nerves, can lead to symptoms such as pain, limitations in the range of joint mobility, malalignment, impaired balance, and difficulty walking. Locomotive syndrome (LoS) was proposed by the Japanese Orthopedic Association in 2007 as a concept for people who are at a high risk of developing a musculoskeletal ambulation disability attributed to locomotor organs. Although many international articles related to LoS have been published, an international consensus of this concept seems to be lacking. Read More

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April 2018
1 Read

The effects of movement stimulation on activities of daily living performance and quality of life in nursing home residents with dementia: a randomized controlled trial.

Clin Interv Aging 2018 30;13:805-817. Epub 2018 Apr 30.

Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Background: Nursing home (NH) residents with dementia experience a reduced quality of life (QoL), in part, due to a dependence in performing activities of daily living (ADL). Stimulating movement is associated with improvements in ADL performance. Therefore, movement stimulating interventions, such as ADL training and exercise, focus on optimizing ADL performance to improve QoL. Read More

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April 2018
1 Read

Longer-term quality of life following major trauma: age only significantly affects outcome after the age of 80 years.

Clin Interv Aging 2018 30;13:773-785. Epub 2018 Apr 30.

Amsler Consulting, Basel, Switzerland.

Aim: Against the background of conflicting data on the topic, this study aimed to determine the differences in longer-term patient outcomes following major trauma with regard to age.

Materials And Methods: A prospective trauma center survey of survivors of trauma (≥16 years) was carried out employing a New Injury Severity Score (NISS) ≥8 to investigate the influence of age on working capacity and several outcome scores, such as the trauma medical outcomes study Short Form-36 (physical component [PCS] and mental component [MCS]), the Euro Quality of Life (EuroQoL), or the Trauma Outcome Profile (TOP) at least 1 year following injury. Chi square tests, -tests, and Pearson correlations were used as univariate; stepwise regression as multivariate analysis. Read More

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April 2018
2 Reads

Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the Rugao Longevity and Ageing Study.

Clin Interv Aging 2018 27;13:797-804. Epub 2018 Apr 27.

Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai, People's Republic of China.

Background: Risk factors for heart rate-corrected QT interval (QTc) proglongation should be explored to stratify high-risk individuals to aid the prevention of incident cardiovascular events and mortality. The diversity of risk factors for QTc prolongation suggests that use of the frailty index (FI), indicating general health deficits, may be an effective approach, especially in the elderly, to identify the risk of QTc prolongation.

Methods: We used the data of 1,780 individuals aged 70-87 years from the Rugao Longevity and Ageing Study (RuLAS), a community-based longitudinal study. Read More

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April 2018
2 Reads

FIMA, the questionnaire for health-related resource use in the elderly population: validity, reliability, and usage of the Polish version in clinical practice.

Clin Interv Aging 2018 27;13:787-795. Epub 2018 Apr 27.

Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.

Purpose: The purpose of this study was to determine the validity and reliability of the Polish version of the Questionnaire for Health-Related Resource Use in an Elderly Population [Fragebogen zur Inanspruchnahme medizinischer und nicht-medizinischer Versorgungsleistungen im Alter (FIMA)].

Patients And Methods: This was a cross-sectional study conducted in a rehabilitation care unit in Poland between January and June of 2017. Sixty-one patients aged ≥65 years who had been admitted to the unit were enrolled into the study. Read More

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April 2018
1 Read

Oxidative stress, aging, and diseases.

Clin Interv Aging 2018 26;13:757-772. Epub 2018 Apr 26.

Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.

Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. Read More

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April 2018
2 Reads

Hospitalized frail elderly patients - atrial fibrillation, anticoagulation and 12 months' outcomes.

Clin Interv Aging 2018 26;13:749-756. Epub 2018 Apr 26.

Department of Acute and Internal Medicine, NU (NÄL-Uddevalla) Hospital Group, Trollhättan-Uddevalla-Vänersborg, Sweden.

Background And Objective: Multiple chronic conditions and recurring acute illness are frequent among elderly people. One such condition is atrial fibrillation (AF), which increases the risk of stroke up to fivefold. The aim of this study was to investigate the prevalence of AF among hospitalized frail elderly patients, their use of anticoagulation and their 12-month outcomes. Read More

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Effectiveness of the "Elderly Activity Performance Intervention" on elderly patients' discharge from a short-stay unit at the emergency department: a quasi-experimental trial.

Clin Interv Aging 2018 26;13:737-747. Epub 2018 Apr 26.

Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital.

Purpose: To examine the effectiveness of the Elderly Activity Performance Intervention on reducing the risk of readmission in elderly patients discharged from a short-stay unit at the emergency department.

Patients And Methods: The study was conducted as a nonrandomized, quasi-experimental trial. Three hundred and seventy-five elderly patients were included and allocated to the Elderly Activity Performance Intervention (n=144) or usual practice (n=231). Read More

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April 2018
2 Reads

Comprehensive geriatric assessment prediction of postoperative complications in gastrointestinal cancer patients: a meta-analysis.

Clin Interv Aging 2018 24;13:723-736. Epub 2018 Apr 24.

Department of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Background: Gastrointestinal cancer is an age-associated disease, and geriatric patients are mostly likely to suffer from postoperative complications. Some studies indicated that comprehensive geriatric assessment (CGA) could predict postoperative complications in gastrointestinal cancer patients. However, the evidence is mixed. Read More

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April 2018
2 Reads

Can a single session of motor imagery promote motor learning of locomotion in older adults? A randomized controlled trial.

Clin Interv Aging 2018 23;13:713-722. Epub 2018 Apr 23.

School of Physiotherapy, Australian Catholic University, Brisbane, QLD, Australia.

Purpose: To investigate the influence of a single session of locomotor-based motor imagery training on motor learning and physical performance.

Patients And Methods: Thirty independent adults aged >65 years took part in the randomized controlled trial. The study was conducted within an exercise science laboratory. Read More

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April 2018
1 Read

Can cochlear implantation improve neurocognition in the aging population?

Clin Interv Aging 2018 20;13:701-712. Epub 2018 Apr 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth-Hospital, Bochum, Germany.

Introduction: The relationship between cognition and the ability to hear is well known. Due to changes in demographics, the number of people with sensorineural hearing loss and cognitive impairment is increasing. The aim of this study was to identify the impact of hearing rehabilitation via cochlear implantation on cognitive decline among the aging population. Read More

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April 2018
1 Read

Deep vein thrombosis in bilateral lower extremities after hip fracture: a retrospective study of 463 patients.

Clin Interv Aging 2018 18;13:681-689. Epub 2018 Apr 18.

Department of Orthopedic Trauma, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Beilin District, Xi'an, Shaanxi, China.

Objective: To investigate the incidences of deep vein thrombosis (DVT) before and after operation in inpatients with hip fractures in both lower extremities.

Patients And Methods: We collected the clinical data of 463 patients with lower extremities fractures who presented at Xi'an Honghui Hospital between July 1, 2014, and October 31, 2016 and met all the inclusion criteria. Doppler ultrasonography was used to diagnose DVT. Read More

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April 2018
2 Reads

Design and implementation of an empowerment model to prevent elder abuse: a randomized controlled trial.

Clin Interv Aging 2018 17;13:669-679. Epub 2018 Apr 17.

Department of Health Education and Health Promotion, School of Health, Iran University of Medical Sciences, Tehran, Iran.

Background: Older adults are more vulnerable to health risks than younger people and may get exposed to various dangers, including elder abuse. This study aimed to design and implement an empowerment educational intervention to prevent elder abuse.

Methods: This parallel randomized controlled trial was conducted in 2014-2016 for 18 months on 464 older adults aged above 60 years who visited health houses of 22 municipalities in Tehran. Read More

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April 2018
3 Reads

Review of antimicrobial use and considerations in the elderly population.

Clin Interv Aging 2018 17;13:657-667. Epub 2018 Apr 17.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

Pharmacologic management of infections in elderly patients presents multiple challenges to health care professionals due to variable pharmacokinetics, pharmacodynamics, and immune function. Age is a well-established risk factor for infection, but furthermore is a risk factor for prolonged length of hospital stay, increased incidence of complications, and significant and sustained decline in baseline functional status. In 2014, 46. Read More

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Reduced ejection fraction heart failure - new data from multicenter studies and national registries regarding general and elderly populations: hopes and disappointments.

Clin Interv Aging 2018 18;13:651-656. Epub 2018 Apr 18.

Cardiology Department, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

The evaluation of patients diagnosed with impaired systolic function heart failure represents a great challenge, in both the general and elderly population. We consider that elderly patients are the most severely affected by this disease that represents the final impact of cardiovascular disease continuum. Cardiovascular diseases are associated with serious morbidity and mortality, and considerable health care costs related to diagnosis and treatment. Read More

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April 2018
2 Reads

Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention.

Clin Interv Aging 2018 17;13:641-649. Epub 2018 Apr 17.

Department of Cardiology, Fujian Provincial Hospital, Fujian Cardiovascular Institute, Fujian Medical University, Fuzhou, People's Republic of China.

Purpose: Inflammatory factors play a critical role in contrast-induced acute kidney injury (CI-AKI). Prealbumin, a nutritional and inflammatory indicator, is a well-established predictor of short- and long-term outcomes in numerous clinical conditions. The current study investigated the association of pre-procedural prealbumin levels with CI-AKI and long-term outcomes in geriatric patients after elective percutaneous coronary intervention (PCI). Read More

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April 2018
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Effects of oral amino acid supplementation on Multidimensional Prognostic Index in hospitalized older patients: a multicenter randomized, double-blind, placebo-controlled pilot study.

Clin Interv Aging 2018 16;13:633-640. Epub 2018 Apr 16.

Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Galliera Hospital, Genova, Italy.

Background: It is not known whether amino acid supplementations may influence health status in hospitalized older acutely ill patients.

Aim: The aim of this study was to determine whether nutritional supplementation with amino acids (Aminoglutam) is associated with multidimensional improvement assessed with the Multidimensional Prognostic Index (MPI).

Methods: In this randomized, double-blind, placebo-controlled pilot clinical trial, 126 patients aged ≥65 years were enrolled from 6 Italian geriatric wards. Read More

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Preferences and attitudes of older adults of Bialystok, Poland toward the use of over-the-counter drugs.

Clin Interv Aging 2018 10;13:623-632. Epub 2018 Apr 10.

Department of Statistics and Medical Informatics, Faculty of Health Sciences, Medical University of Bialystok, Bialystok, Poland.

Purpose: The aim of the study was to assess preferences and attitudes toward the use of over-the-counter (OTC) drugs among residents of Bialystok aged 60 or older.

Patients And Methods: The study included 170 people, inhabitants of Bialystok aged over 60: 85 students of the University of a Healthy Senior and the University of Psychogeriatric Prophylaxis, and 85 students of the University of the Third Age in Bialystok. The study made use of a diagnostic survey conducted via a questionnaire prepared by the authors. Read More

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April 2018
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Good function and high patient satisfaction at mean 2.8 years after dual mobility THA following femoral neck fracture: a cross-sectional study of 124 patients.

Clin Interv Aging 2018 9;13:615-621. Epub 2018 Apr 9.

University Clinic for Hand, Hip and Knee Surgery, Regional Hospital West, Holstebro, Denmark.

Aims: Our aim was to investigate function, health status and satisfaction in patients treated with primary dual mobility (DM) total hip arthroplasty (THA) after displaced femoral neck fracture (FNF).

Patients And Methods: From 2005-2011, 414 consecutive FNF patients received Saturne DM THA. At a minimum of 1-year follow-up, 124 (95 women) were evaluated with Oxford Hip Score (OHS), Harris Hip Score (HHS), health-related quality of life (HRQoL) measure (EQ-5D) and two functional tests: Timed Up and Go (TUG) and Sit to Stand 10 times (STS). Read More

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April 2018
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Costs of medication in older patients: before and after comprehensive geriatric assessment.

Clin Interv Aging 2018 9;13:607-613. Epub 2018 Apr 9.

Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: Polypharmacy and inappropriate drug use cause numerous complications, such as cognitive impairment, frailty, falls, and functional dependence. The present study aimed to determine the effect of the comprehensive geriatric assessment (CGA) on polypharmacy, potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), and to evaluate the economic reflections of medication changes.

Methods: One thousand five hundred and seventy-nine older patients, who had undergone CGA, were retrospectively evaluated. Read More

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April 2018
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