1,833 results match your criteria Clinical Interventions in Aging[Journal]


Effect of genetic polymorphisms on Alzheimer's disease treatment outcomes: an update.

Clin Interv Aging 2019 29;14:631-642. Epub 2019 Mar 29.

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia,

Genetic variations in individuals may cause differences in the response to cholinesterase inhibitor drugs used in the treatment of Alzheimer's disease (AD). Through this review, we aimed to understand the potential relationship between genetic polymorphisms and treatment response in AD. We conducted a systematic review of the studies published from 2006 to 2018 that assessed the relationship between genetic polymorphisms and the pharmacotherapeutic outcomes of patients with AD. Read More

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http://dx.doi.org/10.2147/CIA.S200109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445219PMC
March 2019
1 Read

Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway.

Clin Interv Aging 2019 28;14:621-630. Epub 2019 Mar 28.

Department of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China,

Background: Disc degeneration (DD) is one of the common diseases worldwide, which deeply influences normal life and leads to excruciating pain. However, an effective treatment for DD is still not identified.

Method: The present study systemically examined the effect of melatonin on annulus fibrosus (AF) cells of patients with DD. Read More

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http://dx.doi.org/10.2147/CIA.S193765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445191PMC

Turkish version of the Tilburg Frailty Indicator.

Clin Interv Aging 2019 27;14:615-620. Epub 2019 Mar 27.

Department of Geriatrics, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey,

Background: Recently frailty has drawn significant interest as an important predictor of several clinically relevant outcomes. There is no widely accepted instrument for the assessment of frailty and most of the current ones evaluate only physical features. The Tilburg Frailty Indicator (TFI) is a valid and reliable instrument which enables multidimensional assessment of frailty. Read More

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https://www.dovepress.com/turkish-version-of-the-tilburg-fra
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http://dx.doi.org/10.2147/CIA.S197512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441457PMC
March 2019
2 Reads

Colonoscopy and colorectal cancer rates among octogenarians and nonagenarians: nationwide study of US veterans.

Clin Interv Aging 2019 26;14:609-614. Epub 2019 Mar 26.

Department of Gastroenterology, VA Stratton Medical Center, Albany, NY 12208, USA.

Background: According to Surveillance, Epidemiology and End Results (SEER) database, colorectal cancer (CRC) is the fourth most common type of cancer and second highest in cancer-related death after lung cancer. The SEER database is geographically limited, currently present in only 10-12 states. Though this gives a good approximation about the overall direction of CRC incidence and prevalence, we need more nationwide data to compare numbers. Read More

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http://dx.doi.org/10.2147/CIA.S192497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440444PMC

Tongue-pressure resistance training improves tongue and suprahyoid muscle functions simultaneously.

Clin Interv Aging 2019 22;14:601-608. Epub 2019 Mar 22.

Department of Gerodontology, Division of Gerontology and Gerodontology, Tokyo Medical and Dental University, Tokyo, Japan,

Purpose: Producing tongue pressure (TP) by pushing the tongue against the palate consists of lifting the tongue muscles and elevating the floor of the mouth via suprahyoid muscle contraction. Though studies have shown that tongue-pressure resistance training (TPRT) increases tongue function, none have focused on suprahyoid muscle function enhancements. Our study aimed to verify whether TPRT improves both tongue function and hyoid movement during swallowing. Read More

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http://dx.doi.org/10.2147/CIA.S194808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432900PMC

Evaluation of pharmacist interventions and commonly used medications in the geriatric ward of a teaching hospital in Turkey: a retrospective study.

Clin Interv Aging 2019 21;14:587-600. Epub 2019 Mar 21.

Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine, Ege University, Izmir, Turkey.

Purpose: Aging increases the prevalence of diseases. The elderly population is consequently often exposed to complex medication regimens. Increased drug use is one of the main reasons for drug-related problems (DRPs). Read More

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http://dx.doi.org/10.2147/CIA.S201039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432892PMC

Preserved physical fitness is associated with lower 1-year mortality in frail elderly patients with a severe comorbidity burden.

Clin Interv Aging 2019 18;14:577-586. Epub 2019 Mar 18.

Department of Medical and Health Sciences, Division of Physiotherapy, Linköping University, Linköping, Sweden,

Introduction: Physical deterioration in connection with a care episode is common. The aim of this study was, in frail elderly patients with a severe comorbidity burden, to analyze 1) the association between physical fitness measurements and 1-year mortality and 2) the association between preserved physical fitness during the first three months after discharge from emergency hospital care and 1-year prognosis.

Methods: Frail elderly patients (≥75 years) in need of inpatient emergency medical care were included. Read More

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http://dx.doi.org/10.2147/CIA.S198591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429995PMC
March 2019
2 Reads

Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study.

Clin Interv Aging 2019 15;14:571-575. Epub 2019 Mar 15.

Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China,

Objective: Postoperative delirium (POD) is a serious complication in elderly patients undergoing cardiac surgery. This study was aimed at investigating the effect of perioperative administration of dexmedetomidine for general anesthesia maintenance on occurrence and duration of POD in elderly patients after cardiac surgery.

Methods: One hundred and sixty-four patients were enrolled after cardiac surgery between June 2009 and December 2016. Read More

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http://dx.doi.org/10.2147/CIA.S194476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421898PMC
March 2019
2 Reads

Normobaric oxygen: a novel approach for treating chronic cerebral circulation insufficiency.

Clin Interv Aging 2019 14;14:565-570. Epub 2019 Mar 14.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China,

Chronic cerebral circulation insufficiency (CCCI) is viewed as an alarming state induced by long-term reduction in cerebral perfusion, which is associated with neurological deficits and high risk of stroke occurrence or recurrence. CCCI accounts for a large proportion of both outpatients and inpatients with cerebrovascular diseases, while management of CCCI remains a formidable challenge to clinicians. Normobaric oxygen (NBO) is an adjuvant hyperoxygenation intervention supplied with one atmosphere pressure (1 ATA =101. Read More

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https://www.dovepress.com/normobaric-oxygen-a-novel-approach
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http://dx.doi.org/10.2147/CIA.S190984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421875PMC
March 2019
4 Reads

Endoscopic dissection of refractory pancreatic duct stricture via accessory pancreatic duct approach for concurrent treatment of anomalous pancreaticobiliary junction in aging patients.

Clin Interv Aging 2019 12;14:557-563. Epub 2019 Mar 12.

Department of Gastroenterology and Hepatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan Province 610072, China,

Background: Although endoscopic management of pancreatic strictures by dilation and stenting is well established, some high-grade strictures are refractory to conventional methods. Here, we report a novel technique via accessory pancreatic duct (APD) approach to simultaneously release chronic pancreatitis-associated pancreatic stricture and correct anomalous pancreaticobiliary junction (APBJ). Due to APBJ and stricture of proximal main pancreatic duct, the APD turned out to be compensatory expansion. Read More

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http://dx.doi.org/10.2147/CIA.S191055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419590PMC
March 2019
1 Read
1.824 Impact Factor

Consistency of left ventricular hypertrophy diagnosed by electrocardiography and echocardiography: the Northern Shanghai Study.

Clin Interv Aging 2019 11;14:549-556. Epub 2019 Mar 11.

Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China,

Background: Left ventricular hypertrophy (LVH) is one of the preclinical manifestations of hypertensive target organ damage (TOD). However, it remains unclear which electrocardiographic criterion perform better in diagnosing LVH.

Purpose: To investigate the consistency of LVH diagnosed by electrocardiography (ECG) and echocardiography (ECHO). Read More

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https://www.dovepress.com/consistency-of-left-ventricular-hy
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http://dx.doi.org/10.2147/CIA.S180723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417007PMC
March 2019
9 Reads
1.824 Impact Factor

Identification of potentially inappropriate medications with risk of major adverse cardiac and cerebrovascular events among elderly patients in ambulatory setting and long-term care facilities.

Clin Interv Aging 2019 4;14:535-547. Epub 2019 Mar 4.

Research Institute for Medicines (iMED.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal,

Purpose: Cardiovascular diseases (CVDs) are extremely common among the elderly, but information on the use of potentially inappropriate medications (PIMs) with cardiovascular risk is scarce. We aimed to determine the prevalence of PIMs with risk of cardiac and cerebrovascular adverse events (CCVAEs), including major adverse cardiac and cerebrovascular events (MACCE).

Patients And Methods: A cross-sectional study was performed using a convenience sample from four long-term care facilities and one community pharmacy in Portugal. Read More

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http://dx.doi.org/10.2147/CIA.S192252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404669PMC

Aged kidneys are refractory to autophagy activation in a rat model of renal ischemia-reperfusion injury.

Clin Interv Aging 2019 1;14:525-534. Epub 2019 Mar 1.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China,

Background: Ischemia-reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Numerous therapeutic approaches for I/R injury have been studied, including autophagy, particularly in animal models of renal I/R injury derived from young or adult animals. However, the precise role of autophagy in renal ischemia-reperfusion in the aged animal model remains unclear. Read More

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http://dx.doi.org/10.2147/CIA.S197444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402441PMC
March 2019
1 Read

Improving health-promoting self-care in family carers of people with dementia: a review of interventions.

Clin Interv Aging 2019 1;14:515-523. Epub 2019 Mar 1.

Division of Psychiatry and Applied Psychology, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK,

Background: Providing care for a family member with dementia can leave little time for carers to look after their own health needs, which makes them more susceptible to mental and physical health problems. This scoping review aimed to explore potential health benefits of interventions aimed at improving health-promoting self-care in family carers of people with dementia.

Methods: A scoping review was carried out using Arksey and O'Malley's methodological framework. Read More

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http://dx.doi.org/10.2147/CIA.S190610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402440PMC

Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment.

Clin Interv Aging 2019 8;14:505-514. Epub 2019 Mar 8.

University Clinical Center, University Hospital Medical University of Silesia, Katowice, Poland,

Purpose: To present optical coherence tomography (OCT) angiography features in patients with idiopathic full-thickness macular hole before and after vitrectomy.

Study Design: Prospective case series study.

Materials And Methods: Patients presenting with an idiopathic full-thickness macular hole (IMH) who underwent posterior vitrectomy with internal limiting membrane peeling and gas tamponade were included in the study. Read More

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http://dx.doi.org/10.2147/CIA.S189417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413747PMC

The mean platelet volume on admission predicts unfavorable stroke outcomes in patients treated with IV thrombolysis.

Clin Interv Aging 2019 27;14:493-503. Epub 2019 Feb 27.

Clinic of Neurology, Military Institute of Medicine, Warsaw, Poland,

Purpose: The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in patients with AIS following rt-PA treatment.

Patients And Methods: This was a retrospective analysis of 237 AIS patients (mean age 71. Read More

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http://dx.doi.org/10.2147/CIA.S195451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398411PMC
February 2019
3 Reads

Factors associated with the efficiency of hearing aids for patients with age-related hearing loss.

Clin Interv Aging 2019 26;14:485-492. Epub 2019 Feb 26.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China,

Objective: The aim of this study was to investigate the satisfaction of age-related hearing loss (ARHL) or presbycusis patients with individual, accurate, and precise fitting progress, which is a priority for bilateral hearing aids, and to explore the related influencing factors and their role in predicting the efficiency of hearing aids.

Methods: A total of 73 cases of presbycusis patients aged 60-95 years old underwent pure tone audiometry and speech recognition ability examination to obtain the pure tone audiometry of the better ear (BPTA) and maximum speech recognition rate of the better ear (BSRR) in quiet environment before hearing aid fitting. Audiologists evaluated the efficiency and satisfaction of participants according to the International Outcome Inventory for Hearing Aids (IOI-HA) questionnaire scores by face-to-face or telephone investigations after using the hearing aids for at least 3 months. Read More

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https://www.dovepress.com/factors-associated-with-the-effici
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http://dx.doi.org/10.2147/CIA.S190651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396655PMC
February 2019
2 Reads

Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people.

Clin Interv Aging 2019 25;14:473-484. Epub 2019 Feb 25.

Institute for Biomedicine of Ageing (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-90408 Nürnberg, Germany,

Background: We aimed to evaluate the abilities of a 21-item frailty index based on laboratory blood and urine tests (FI-Lab21) assessed at different points in time, ie, at admission to hospital (FI-Lab21) and before discharge from hospital (FI-Lab21), and the change of the FI-Lab21 during the hospital stay to predict 6-month and 1-year mortality in hospitalized geriatric patients.

Methods: Five hundred hospitalized geriatric patients aged ≥65 years were included in this analysis. Follow-up data were acquired after a period of 6 months and 1 year. Read More

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http://dx.doi.org/10.2147/CIA.S191117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394369PMC
February 2019

Investigating the utility of teletherapy in individuals with primary progressive aphasia.

Clin Interv Aging 2019 25;14:453-471. Epub 2019 Feb 25.

Communication Sciences and Disorders, University of Texas at Austin, Austin, TX, USA,

Introduction: Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive deterioration of speech and language. A growing body of research supports the utility of speech and language intervention in individuals with PPA, although access to these services remains limited. One potential means of increasing treatment accessibility is the delivery of treatment via telemedicine. Read More

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http://dx.doi.org/10.2147/CIA.S178878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394239PMC
February 2019
1 Read

Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years.

Clin Interv Aging 2019 25;14:445-451. Epub 2019 Feb 25.

Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China,

Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years.

Patients And Methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Read More

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http://dx.doi.org/10.2147/CIA.S164021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394237PMC
February 2019

Modified frailty as a novel factor in predicting the response to cardiac resynchronization in the elderly population.

Clin Interv Aging 2019 25;14:437-443. Epub 2019 Feb 25.

Department of Electrocardiology, Upper Silesian Heart Centre, Katowice, Poland,

Background: The response to cardiac resynchronization therapy (CRT) is an important element of the treatment of advanced heart failure, especially in the geriatric population. The aim of the study was to examine the impact of frailty syndrome on the response to treatment with CRT.

Methods: Two hundred and forty-six patients of 60 years or older (aged 73. Read More

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http://dx.doi.org/10.2147/CIA.S193577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394238PMC
February 2019

Delirium after hip hemiarthroplasty for proximal femoral fractures in elderly patients: risk factors and clinical outcomes.

Clin Interv Aging 2019 26;14:427-435. Epub 2019 Feb 26.

Surgery Department, Maasstad Hospital, 3079 DZ Rotterdam, the Netherlands,

Background: The primary aim of the present study was to verify the potential risk factors for developing a delirium after hip fracture surgery. The secondary aim of this study was to examine the related clinical outcomes after a delirium developed post-hip fracture surgery.

Patients And Methods: Data were extracted from a prospective hip fracture database and completed by retrospective review of the hospital records. Read More

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https://www.dovepress.com/delirium-after-hip-hemiarthroplast
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http://dx.doi.org/10.2147/CIA.S189760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396663PMC
February 2019
8 Reads

Trialing an online intervention to improve retirement planning goal setting and goal specificity.

Clin Interv Aging 2019 21;14:419-425. Epub 2019 Feb 21.

School of Psychology, The University of New South Wales, Sydney, NSW 2052, Australia.

Purpose: Time perspective (TP) is the term used to describe people's preferences to focus on the past, present, and the future. Previous research demonstrates a link between TP and retirement planning. The objective of this study was to evaluate a TP-based online training intervention to improve retirement planning emphasizing the accumulation of resources. Read More

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https://www.dovepress.com/trialing-an-online-intervention-to
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http://dx.doi.org/10.2147/CIA.S189072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388977PMC
February 2019
2 Reads

A mixed analysis approach to elucidate the multiple chronic condition experience of English- and Spanish-speaking older adults.

Clin Interv Aging 2019 20;14:407-418. Epub 2019 Feb 20.

Department of Psychiatry and Behavioral Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA,

Background: Having multiple chronic conditions (MCCs) is the most common health condition in older adults. The management of each condition presents many challenges. A key factor in patients' ability to manage their own health care is their level of health literacy. Read More

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https://www.dovepress.com/a-mixed-analysis-approach-to-eluci
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http://dx.doi.org/10.2147/CIA.S193215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388757PMC
February 2019
8 Reads

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis.

Clin Interv Aging 2019 20;14:399-406. Epub 2019 Feb 20.

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China,

Aim: We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle.

Methods: Randomized controlled trials of dutasteride and finasteride for treating AGA were searched using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The data were calculated using Rev Man v5. Read More

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http://dx.doi.org/10.2147/CIA.S192435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388756PMC
February 2019
4 Reads

Current and emerging biomarkers of frailty in the elderly.

Clin Interv Aging 2019 19;14:389-398. Epub 2019 Feb 19.

Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Melbourne, VIC, Australia,

The term "frailty" is used to describe a subset of older adults who appear weaker and more vulnerable than their age-matched counterparts, despite having similar comorbidities, demography, sex, and age. The diagnosis of frailty is usually clinical and based on specific criteria, which are sometimes inconsistent. Therefore, there is an increasing need to identify and validate robust biomarkers for this condition. Read More

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http://dx.doi.org/10.2147/CIA.S168687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388773PMC
February 2019
1 Read

The impact of frailty on prolonged hospitalization and mortality in elderly inpatients in Vietnam: a comparison between the frailty phenotype and the Reported Edmonton Frail Scale.

Clin Interv Aging 2019 20;14:381-388. Epub 2019 Feb 20.

The National Geriatric Hospital, Hanoi, Vietnam,

Aims: To investigate the impact of frailty on outcomes in older hospitalized patients, including prolonged length of stay and all-cause mortality 6 months after admission, using both the frailty phenotype and the Reported Edmonton Frail Scale (REFS).

Patients And Methods: This study is the follow-up phase of a study designed to investigate the prevalence of frailty and its impact on adverse outcomes in older hospitalized patients at the National Geriatric Hospital in Hanoi, Vietnam.

Results: A total of 461 participants were included, with a mean age 76. Read More

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https://www.dovepress.com/the-impact-of-frailty-on-prolonged
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http://dx.doi.org/10.2147/CIA.S189122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388754PMC
February 2019
5 Reads

Dorsal and ventral thoracic 12 vertebra body height is associated with incident lumbar vertebral fracture in postmenopausal osteoporotic women.

Clin Interv Aging 2019 15;14:375-380. Epub 2019 Feb 15.

Department of Anesthesiology and Pain Medicine, Catholic Kwandong University, College of Medicine, International St. Mary's Hospital, Incheon, Korea,

Purpose: We measured dorsal and ventral thoracic 12 vertebral (T12V) body heights as a way to predict lumbar vertebral fracture (LVF) in postmenopausal women. MRI of dorsal and ventral T12V body heights has not yet been used to investigate their association with LVF. We hypothesized that the dorsal and ventral T12V body height are important morphologic parameters in the prediction of LVF. Read More

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http://dx.doi.org/10.2147/CIA.S199402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388793PMC
February 2019
1 Read

Associations between obesity and cognitive impairment in the Chinese elderly: an observational study.

Clin Interv Aging 2019 15;14:367-373. Epub 2019 Feb 15.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China,

Purpose: The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly.

Patients And Methods: Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May 2017. Mini-Mental State Examination scale was used to assess the cognitive function. Read More

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https://www.dovepress.com/associations-between-obesity-and-c
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http://dx.doi.org/10.2147/CIA.S192050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388776PMC
February 2019
9 Reads

Trends of surgical treatment for spinal degenerative disease in China: a cohort of 37,897 inpatients from 2003 to 2016.

Clin Interv Aging 2019 15;14:361-366. Epub 2019 Feb 15.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China,

Purpose: Given the aging Chinese population and the inevitable degenerative process of the spine, more elderly patients with spinal degenerative disease (SDD) are surgical candidates, placing a significant burden on health care resources. Few studies have investigated recent trends in hospital admissions and procedures for SDD in China. This study aimed to identify the trends, if any, in the number of surgical procedures undertaken for SDD in a large patient cohort. Read More

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http://dx.doi.org/10.2147/CIA.S191449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388778PMC
February 2019
1 Read
1.824 Impact Factor

A game-based neurofeedback training system to enhance cognitive performance in healthy elderly subjects and in patients with amnestic mild cognitive impairment.

Clin Interv Aging 2019 19;14:347-360. Epub 2019 Feb 19.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Introduction: This study examines the clinical efficacy of a game-based neurofeedback training (NFT) system to enhance cognitive performance in patients with amnestic mild cognitive impairment (aMCI) and healthy elderly subjects. The NFT system includes five games designed to improve attention span and cognitive performance. The system estimates attention levels by investigating the power spectrum of Beta and Alpha bands. Read More

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http://dx.doi.org/10.2147/CIA.S189047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388796PMC
February 2019
2 Reads

Effectiveness of robotics fall prevention program among elderly in senior housings, Bangkok, Thailand: a quasi-experimental study.

Clin Interv Aging 2019 18;14:335-346. Epub 2019 Feb 18.

Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Objective: This study aimed at investigating the effectiveness of a robotic fall prevention program on knowledge, exercises, balance, and incidence of falls among elderly in senior housings.

Patients And Methods: This is a quasi-experimental study. Sixty-four elderly in two senior housings in Bangkok with Barthel Index scale ≥12, who had either at least one fall experience in the past 12 months and/or had Timed Up and Go (TUG) test ≥20 seconds were recruited and purposively assigned to the intervention group (received a small robot-installed fall prevention software, personal coaching, and handbook, n=32) and control group (received only handbook, n=32). Read More

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http://dx.doi.org/10.2147/CIA.S182336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388770PMC
February 2019
1.824 Impact Factor

Handling of informed consent and patient inclusion in research with geriatric trauma patients - a matter of protection or disrespect?

Clin Interv Aging 2019 13;14:321-334. Epub 2019 Feb 13.

Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Basel 4031, Switzerland,

Background: Despite the aging of numerous societies and future health care challenges, clinical research in the elderly is underrepresented. The aim of this review was to analyze the current practice exemplary in gerontotraumatology and to discuss potential improvements.

Materials And Methods: A literature review was performed in 2016 based on a PubMed search for gerontotraumatologic studies published between 2005 and 2015. Read More

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http://dx.doi.org/10.2147/CIA.S191751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388780PMC
February 2019
8 Reads

Positive physical and mental outcomes for residents in nursing facilities using music: a systematic review.

Clin Interv Aging 2019 12;14:301-319. Epub 2019 Feb 12.

School of Social Work, Texas State University, San Marcos, TX 78666, USA.

Objectives: The objective of this study was to investigate the applicability and effectiveness of the use of music in providing for positive physical and mental outcomes in nursing facilities.

Problem: Lack of quality of life (QOL) has been a significant issue within nursing facilities. With the rise in census due to Baby Boomers, it has become imperative to find ways to increase overall QOL. Read More

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https://www.dovepress.com/positive-physical-and-mental-outco
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http://dx.doi.org/10.2147/CIA.S189486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388774PMC
February 2019
8 Reads

Reliability and usability of a weighted version of the Functional Comorbidity Index.

Clin Interv Aging 2019 11;14:289-299. Epub 2019 Feb 11.

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands,

Purpose: To investigate the reliability of a weighted version of the Functional Comorbidity Index (w-FCI) compared with that of the original Functional Comorbidity Index (FCI) and to test its usability.

Patients And Methods: Sixteen physicians collected data from 102 residents who lived in 16 different nursing homes in the Netherlands. A multicenter, prospective observational study was carried out in combination with a qualitative part using the three-step test interview, in which participants completed the w-FCI while thinking aloud and being observed, and were then interviewed afterward. Read More

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http://dx.doi.org/10.2147/CIA.S185112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375535PMC
April 2019
3 Reads

An intensive swallowing exercise protocol for improving swallowing physiology in older adults with radiographically confirmed dysphagia.

Clin Interv Aging 2019 11;14:283-288. Epub 2019 Feb 11.

Department of Communicative Sciences and Disorder, Communicative Sciences and Disorders, New York University Steinhardt, New York, NY, USA,

Purpose: The aim of this study was to investigate improvements in swallowing function and physiology in a series of healthy older adults with radiographically confirmed dysphagia, following completion of an exercise-based swallowing intervention.

Patients And Methods: Nine otherwise healthy older adults (six females, mean age =75.3, SD =5. Read More

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http://dx.doi.org/10.2147/CIA.S194723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375531PMC
April 2019
2 Reads

Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients.

Clin Interv Aging 2019 7;14:271-281. Epub 2019 Feb 7.

Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands,

Background/aims: The pathophysiology of delirium is poorly understood. Increasing evidence suggests that different pathways might be involved in the pathophysiology depending on the population studied. The aim of the present study was to investigate potential differences in mean plasma levels of neopterin, amino acids, amino acid ratios and homovanillic acid between two groups of patients with delirium. Read More

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http://dx.doi.org/10.2147/CIA.S193605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369845PMC
February 2019
1 Read

Bracing after percutaneous vertebroplasty for thoracolumbar osteoporotic vertebral compression fractures was not effective.

Clin Interv Aging 2019 5;14:265-270. Epub 2019 Feb 5.

Department of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaan'xi Province, China,

Objective: The objective of this study was to evaluate the effectiveness of bracing after percutaneous vertebroplasty (PVP) for thoracolumbar osteoporotic vertebral compression fractures (OVCF).

Methods: This is a retrospective study where we recruited 138 patients with single-level thoracolumbar OVCF who underwent PVP from January 2018 to March 2018 without bracing after PVP (Group A). The visual analog score (VAS) and vertebral body compression ratio (VCR) were recorded at preoperation, on the second day, at 2 weeks, 1 month, and 6 months after operation. Read More

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http://dx.doi.org/10.2147/CIA.S192821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368123PMC
April 2019
2 Reads

Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries () in healthy human subjects.

Clin Interv Aging 2019 4;14:253-263. Epub 2019 Feb 4.

NIS Labs, Klamath Falls, OR 97601, USA.

Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects.

Study Design And Methods: A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Read More

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http://dx.doi.org/10.2147/CIA.S186893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368418PMC
April 2019
2 Reads

Use of transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction.

Clin Interv Aging 2019 1;14:249-252. Epub 2019 Feb 1.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China,

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http://dx.doi.org/10.2147/CIA.S197922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363397PMC
March 2019
1 Read

The effects of sociodemographic factors on quality of life among people aged 50 years or older are not unequivocal: comparing SF-12, WHOQOL-BREF, and WHOQOL-OLD.

Clin Interv Aging 2019 30;14:231-239. Epub 2019 Jan 30.

Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Objective: The effects of sociodemographic factors on quality of life in older people differ strongly, possibly due to the fact that different measurement instruments have been used. The main aim of this cross-sectional study is to compare the associations of sex, age, marital status, education, and income with quality of life assessed with the Short-Form Health Survey (SF-12), the World Health Organization Quality of Life Questionnaire-BREF (WHOQOL-BREF), and the World Health Organization Quality of Life Questionnaire-Older Adults Module (WHOQOL-OLD).

Methods: The associations between sociodemographic factors and eleven quality of life domains were examined using a sample of 1,492 Dutch people aged ≥50 years. Read More

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http://dx.doi.org/10.2147/CIA.S189560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363394PMC
January 2019
4 Reads

Osmotic stress and mortality in elderly patients with kidney failure: a retrospective study.

Clin Interv Aging 2019 30;14:225-229. Epub 2019 Jan 30.

Department of Nephrology, University Côte d'Azur, University Hospital of Nice, Nice, France.

Purpose: Water balance disorders are associated with a high risk of death in elderly patients. The role of osmotic stress intensity and its direction toward hypo- or hypernatremia is a matter of controversy regarding patients' survival. The aims of this study were, first, to measure the frequency of cellular hydration disorders in patients over 75 years old hospitalized in nephrology department for reversible acute renal failure, and second, to compare the impact of hyperhydration and hypohydration on the risk of death at 6 months. Read More

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http://dx.doi.org/10.2147/CIA.S158987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363396PMC
January 2019
4 Reads

Indicators of oral health in older adults with and without the presence of multimorbidity: a cross-sectional study.

Clin Interv Aging 2019 30;14:219-224. Epub 2019 Jan 30.

Academic Area of Dentistry, Health Sciences Institute, Autonomous University of Hidalgo State, Pachuca, Mexico,

Purpose: The aim of this study was to determine whether there are differences in the distribution of various indicators of oral health among elderly people with and without multimorbidity (ie, two or more chronic diseases).

Subjects And Methods: A cross-sectional, comparative study was conducted using a sample of Mexican elderly individuals aged ≥60 years. The average age of the cohort was 79. Read More

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http://dx.doi.org/10.2147/CIA.S170470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363395PMC
January 2019
1 Read

Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea.

Clin Interv Aging 2019 31;14:241-247. Epub 2019 Jan 31.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan,

Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).

Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. Read More

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http://dx.doi.org/10.2147/CIA.S193448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362916PMC

Investigating dose-response effects of multimodal exercise programs on health-related quality of life in older adults.

Clin Interv Aging 2019 24;14:209-217. Epub 2019 Jan 24.

Department of Medicine, University of Montreal, Montreal, Quebec, Canada,

Background: Older adults are at risk of multiple chronic diseases, most of which could be prevented by engaging in regular physical activity. Frailty is a state of increased vulnerability to diseases. Worsening symptoms of frailty, such as decrease in physical functionality, can compromise health-related quality of life (HR-QOL). Read More

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https://www.dovepress.com/investigating-dosendashresponse-ef
Publisher Site
http://dx.doi.org/10.2147/CIA.S187534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352872PMC
March 2019
4 Reads

Feasibility and efficacy of enhanced recovery after surgery protocol in Chinese elderly patients with intracranial aneurysm.

Clin Interv Aging 2019 23;14:203-207. Epub 2019 Jan 23.

Department of Neurosurgery, Inner Mongolia Xing'an Meng People's Hospital, Ulanhot 137400, China,

Objective: Intracranial aneurysm is a kind of severe intracranial disease mainly responsible for subarachnoid hemorrhage, and the rupture of intracranial aneurysm results in a mortality rate of 30%-40%. For the first time in the world, this study aimed to assess the feasibility and efficacy of enhanced recovery after surgery (ERAS) protocol in Chinese elderly patients with intracranial aneurysm.

Methods: In this study, 300 elderly patients with intracranial aneurysm were recruited and divided into two groups as follows: ERAS group (n=150, ERAS protocol) and control group (n=150, conventional management). Read More

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https://www.dovepress.com/feasibility-and-efficacy-of-enhanc
Publisher Site
http://dx.doi.org/10.2147/CIA.S187967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350647PMC
April 2019
6 Reads
1.824 Impact Factor

Acute kidney injury after transcatheter aortic valve replacement in the elderly: outcomes and risk management.

Clin Interv Aging 2019 21;14:195-201. Epub 2019 Jan 21.

Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland,

Aortic stenosis is the most common cause of valve replacement in Europe and North America with prevalence increasing with age. Transcatheter valve replacement (TAVR) represents an alternative for surgical valve replacement of severely stenotic valves. Despite lower risk of acute kidney injury compared to that associated with surgery, this complication remains prevalent in patients undergoing TAVR. Read More

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http://dx.doi.org/10.2147/CIA.S149916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345183PMC
March 2019
2 Reads

Illness representations of dementia: a scoping review.

Clin Interv Aging 2019 18;14:179-193. Epub 2019 Jan 18.

Department of Community Mental Health, University of Haifa, Haifa, Israel.

As the number of persons with dementia grows, an increasing number of families, professionals, and laypersons will come into contact with persons with cognitive deterioration. Assessing dementia illness representations (IRs) among these groups may have great importance for understanding their responses to dementia. The purpose of this study was to summarize and critically review the literature on dementia IRs. Read More

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http://dx.doi.org/10.2147/CIA.S193316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342146PMC
March 2019
1 Read

Carotid artery calcification score and its association with cognitive impairment.

Clin Interv Aging 2019 18;14:167-177. Epub 2019 Jan 18.

Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China,

Purpose: To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impairment in carotid artery stenosis (CAS) patients.

Patients And Methods: Carotid artery was measured in 102 patients with cervical carotid arteries using Color Doppler ultrasound, multi-detector row spiral CT angiography and MRI scanning. Correlation analysis between CSs obtained by MD CT and cognitive scores was performed, and the correlation between CSs and vascular stenosis degree and MRI-measured plaque histological (lipid-rich necrotic nucleus [LRNC], intraplaque hemorrhage and fibrous cap surface rupture) and morphological parameters (lumen area [LA], wall area [WA], total area of blood vessels [TVA], plaque burden [PB]) was analyzed. Read More

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https://www.dovepress.com/carotid-artery-calcification-score
Publisher Site
http://dx.doi.org/10.2147/CIA.S192586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342141PMC
March 2019
7 Reads

The relationship between sleep disturbances and quality of life in elderly patients with hypertension.

Clin Interv Aging 2019 15;14:155-165. Epub 2019 Jan 15.

Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, 51-618 Wroclaw, Poland.

Purpose: Sleep disorders, such as insomnia with objective short sleep duration, are associated with increased risk of hypertension. The objective of the study was to evaluate the effects of insomnia and daytime sleepiness on the quality of life (QOL) among elderly hypertensive patients.

Patients And Methods: This cross-sectional study covered 100 patients with hypertension. Read More

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http://dx.doi.org/10.2147/CIA.S188499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339653PMC
March 2019
4 Reads