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    1431 results match your criteria Clinical Interventions in Aging[Journal]

    1 OF 29

    Evaluation on the implementation of respiratory protection measures in old age homes.
    Clin Interv Aging 2017 11;12:1429-1438. Epub 2017 Sep 11.
    Sau Po Centre on Ageing, The University of Hong Kong, Pok Fu Lam, Hong Kong.
    Purpose: Old age homes (OAHs) represent a vulnerable community for influenza outbreaks. Effective implementation of respiratory protection measures has been identified as an effective prevention measure to reduce mortality and morbidity caused by such outbreaks. Yet, relatively little is known about this aspect in these homes. Read More

    Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.
    Clin Interv Aging 2017 8;12:1419-1428. Epub 2017 Sep 8.
    Charles Perkins Centre, University of Sydney, Sydney.
    Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Read More

    Five-year durability of stand-alone interspinous process decompression for lumbar spinal stenosis.
    Clin Interv Aging 2017 6;12:1409-1417. Epub 2017 Sep 6.
    Independent Consultant, Chicago, IL, USA.
    Background: Lumbar spinal stenosis is the most common indication for spine surgery in older adults. Interspinous process decompression (IPD) using a stand-alone spacer that functions as an extension blocker offers a minimally invasive treatment option for intermittent neurogenic claudication associated with spinal stenosis.

    Methods: This study evaluated the 5-year clinical outcomes for IPD (Superion(®)) from a randomized controlled US Food and Drug Administration (FDA) noninferiority trial. Read More

    Gene expression levels of the insulin-like growth factor family in patients with AMD before and after ranibizumab intravitreal injections.
    Clin Interv Aging 2017 5;12:1401-1408. Epub 2017 Sep 5.
    Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
    Purpose: The present study focused on the assessment of the mRNA levels of the insulin-like growth factor (IGF) family in patients with the exudative form of age-related macular degeneration (AMD) before and after ranibizumab intravitreal injections.

    Patients And Methods: An analysis of the expression profile of the IGF family of genes in patients with AMD was carried out using the oligonucleotide microarray and quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) methods.

    Results: In the peripheral blood mononuclear cells (PBMCs) obtained from AMD group receiving ranibizumab compared to the peripheral blood mononuclear cells from AMD group before ranibizumab treatment using oligonucleotide microarray technique, six statistically significant differentially expressed transcripts related to the IGF family were detected (unpaired t-test, p<0. Read More

    Correlations between satisfaction with life and selected personal resources among students of Universities of the Third Age.
    Clin Interv Aging 2017 31;12:1391-1399. Epub 2017 Aug 31.
    Department of Pedagogy and Nursing Didactics, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.
    Purpose: The aim of the study was to identify personal resources, including health-related resources, sense of self-efficacy, attitude to life (optimism/pessimism) and self-assessment, and to determine their relationship with satisfaction with life in members of the Universities of the Third Age (U3As) in Poland. The impact of sociodemographic factors was analyzed.

    Materials And Methods: The study included 320 participants of U3As; their mean age was 67. Read More

    Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol.
    Clin Interv Aging 2017 30;12:1379-1389. Epub 2017 Aug 30.
    Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium.
    Background: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. Read More

    Analysis of the dynamics of venous blood flow in the context of lower limb temperature distribution and tissue composition in the elderly.
    Clin Interv Aging 2017 28;12:1371-1378. Epub 2017 Aug 28.
    Department of Physiotherapy and Occupational Therapy in Conservative and Interventional Medicine, University of Physical Education in Wroclaw, Wroclaw, Poland.
    Objective: The elderly are particularly vulnerable to degenerative diseases, such as circulatory and respiratory system and vascular system diseases. The objective of this study was therefore to evaluate the distribution of temperature and the dynamics of venous blood flow in the lower limbs (LLs) and to assess the interdependence of these parameters in terms of the somatic components in males and females participating in activities at the University of the Third Age.

    Materials And Methods: The study included 60 females (mean age 67. Read More

    Assessing balance through the use of a low-cost head-mounted display in older adults: a pilot study.
    Clin Interv Aging 2017 26;12:1363-1370. Epub 2017 Aug 26.
    Department of Biostatistical Sciences, Wake Forest School of Medicine.
    Introduction: As the population ages, the prevention of falls is an increasingly important public health problem. Balance assessment forms an important component of fall-prevention programs for older adults. The recent development of cost-effective and highly responsive virtual reality (VR) systems means new methods of balance assessment are feasible in a clinical setting. Read More

    Spontaneous cervical artery dissection in patients aged over 70 years: two cases and systematic literature review.
    Clin Interv Aging 2017 26;12:1355-1362. Epub 2017 Aug 26.
    Department of Neurology, Stroke Unit, University Hospital of Nancy, Nancy Cedex, France.
    Objective: Spontaneous cervical artery dissection (CAD) is a cerebrovascular disease typically considered to affect the young population. Literature reports cases in the elderly only as incidental findings, making the diagnosis unlikely in older patients. Incidence and pathogeny in this specific population remain to be assessed. Read More

    Impact of age on extracorporeal membrane oxygenation survival of patients with cardiac failure.
    Clin Interv Aging 2017 24;12:1347-1353. Epub 2017 Aug 24.
    Department of Internal Medicine, St Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea.
    Purpose: Extracorporeal membrane oxygenation (ECMO) is used to treat patients in critical condition with cardiogenic shock. However, few studies have examined the effect of old age in ECMO survival. This study analyzed the impact of age on ECMO survival of patients with cardiac failure, and analyzed predictive factors for survival according to age. Read More

    Vascular aging and subclinical atherosclerosis: why such a "never ending" and challenging story in cardiology?
    Clin Interv Aging 2017 23;12:1339-1345. Epub 2017 Aug 23.
    Department of Preventive Medicine, Angiogenesis Research Center, "Victor Babes" University of Medicine and Pharmacy.
    The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: "A man is as old as his arteries." Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications. Read More

    Sex differences in the effect of aging on dry eye disease.
    Clin Interv Aging 2017 22;12:1331-1338. Epub 2017 Aug 22.
    Department of Ophthalmology, Gachon University Gil Medical Center.
    Purpose: Aging is a major risk factor in dry eye disease (DED), and understanding sexual differences is very important in biomedical research. However, there is little information about sex differences in the effect of aging on DED. We investigated sex differences in the effect of aging and other risk factors for DED. Read More

    Recent developments in age-related macular degeneration: a review.
    Clin Interv Aging 2017 22;12:1313-1330. Epub 2017 Aug 22.
    Department of Ophthalmology, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia.
    Background: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals.

    Objective: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease. Read More

    eGFRs from Asian-modified CKD-EPI and Chinese-modified CKD-EPI equations were associated better with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study.
    Clin Interv Aging 2017 18;12:1297-1308. Epub 2017 Aug 18.
    Department of Cardiology, Shanghai Tenth People's Hospital.
    Background: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Read More

    Association between body composition and stair negotiation ability among individuals >55 years of age: a cross-sectional study.
    Clin Interv Aging 2017 18;12:1289-1296. Epub 2017 Aug 18.
    Department of Public Health, Postgraduate Program in Public Health, State University of Londrina (UEL), Londrina, Paraná, Brazil.
    Background: Loss of muscle strength exerts a considerable impact on the quality of life and mortality of older adults. The present household survey study measured body composition and muscle strength with the aim of analyzing the roles of low lean mass, low muscle strength and obesity in stair negotiation ability and the effect of comorbidities on the relationship between body composition and functional capacity.

    Methods: Body composition was assessed using bioelectrical impedance analysis and muscle strength was assessed with a hand grip dynamometer. Read More

    Aging and extrapulmonary effects of chronic obstructive pulmonary disease.
    Clin Interv Aging 2017 16;12:1281-1287. Epub 2017 Aug 16.
    Faculty of Medicine, Internal Medicine Discipline, Medical Clinical Disciplines I, "Ovidius" University of Constanta, Constanţa.
    Introduction: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. Read More

    Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease.
    Clin Interv Aging 2017 10;12:1271-1279. Epub 2017 Aug 10.
    Department of Geriatrics, Peking University First Hospital, Beijing, China.
    Objectives: Previous studies have illustrated the link between high on-aspirin platelet reactivity (HAPR) with increasing thrombotic risks. The aim of our study was to investigate relative risk factors of HAPR in elderly patients with coronary artery disease.

    Methods: Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016. Read More

    MRI assessment of whole-brain structural changes in aging.
    Clin Interv Aging 2017 9;12:1251-1270. Epub 2017 Aug 9.
    Health Sciences and Innovation, ImageTech Laboratory, Fraser Health Authority, Surrey, BC, Canada.
    Purpose: One of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. Read More

    Acute care of severely frail elderly patients in a CGA-unit is associated with less functional decline than conventional acute care.
    Clin Interv Aging 2017 8;12:1239-1249. Epub 2017 Aug 8.
    Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: A high percentage of individuals treated in specialized acute care wards are frail and elderly. Our aim was to study whether the acute care of such patients in a comprehensive geriatric assessment (CGA) unit is superior to care in a conventional acute medical care unit when it comes to activities of daily living (ADLs), frailty, and use of municipal help services.

    Patients And Methods: A clinical, prospective, controlled trial with two parallel groups was conducted in a large county hospital in West Sweden and included 408 frail elderly patients, age 75 or older (mean age 85. Read More

    R2(GFR)CHADS2 and R2(GFR)CHA2DS2VASc schemes improved the performance of CHADS2 and CHA2DS2VASc scores in death risk stratification of Chinese older patients with atrial fibrillation.
    Clin Interv Aging 2017 8;12:1233-1238. Epub 2017 Aug 8.
    Department of Geriatric Cardiology.
    Background: This analysis was carried out to refine the CHADS2 and CHA2DS2VASc scores by combining creatinine clearance (CrCl) and glomerular filtration rate (GFR) and evaluate the performance of CrCl-based and GFR-based schemes in death risk stratification of Chinese older patients with atrial fibrillation (AF).

    Methods: There were 219 older patients with AF, and all-cause mortality was assessed during the follow-up of 1.11 years. Read More

    Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial.
    Clin Interv Aging 2017 8;12:1223-1231. Epub 2017 Aug 8.
    Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Purpose: To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using a randomized, blank-controlled, parallel-group design.

    Patients And Methods: Two hundred and five volunteers aged ≥45 years were randomly divided into two groups. The subjects in the intervention group were orally administered 300 mL/d of yogurt supplemented with a probiotic strain, Lactobacillus paracasei N1115 (N1115), 3. Read More

    Effects of carbonated liquid on swallowing dysfunction in dementia with Lewy bodies and Parkinson's disease dementia.
    Clin Interv Aging 2017 8;12:1215-1222. Epub 2017 Aug 8.
    Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University.
    Background: Swallowing dysfunction is an increasingly recognized problem in patients with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), which can result in aspiration pneumonia and death. Few studies have examined potential ways of improving swallowing function in this fragile patient group. The aim of this study was to evaluate swallowing dysfunction and carbonated liquid using videofluoroscopy in DLB and PDD patients. Read More

    Relationship between tongue strength, lip strength, and nutrition-related sarcopenia in older rehabilitation inpatients: a cross-sectional study.
    Clin Interv Aging 2017 3;12:1207-1214. Epub 2017 Aug 3.
    Department of Dysphagia Rehabilitation, Nihon University School of Dentistry.
    Objective: The objective of this study was to clarify the relationship between tongue strength, lip strength, and nutrition-related sarcopenia (NRS).

    Patients And Methods: A total of 201 older inpatients aged ≥65 years (70 men, median age: 84 years, interquartile range: 79-89 years) consecutively admitted for rehabilitation were included in this cross-sectional study. The main factors evaluated were the presence of NRS diagnosed by malnutrition using the Mini-Nutrition Assessment - Short Form, sarcopenia based on the criteria of the Asian Working Group for Sarcopenia, tongue strength, and lip strength. Read More

    Texture-modified food and fluids in dementia and residential aged care facilities.
    Clin Interv Aging 2017 2;12:1193-1203. Epub 2017 Aug 2.
    Aged and Chronic Care Department, Concord Repatriation General Hospital, Concord, NSW, Australia.
    Introduction: Dysphagia is common in people living with dementia and associated with increased risk of aspiration pneumonia, dehydration, malnutrition, and death. Treatment options are limited and the use of texture-modified food and fluids (TMF) is a widespread clinical practice. This review aimed to evaluate the evidence for TMF in dementia. Read More

    Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women.
    Clin Interv Aging 2017 2;12:1183-1191. Epub 2017 Aug 2.
    Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
    Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function.

    Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Read More

    Effects of hearing loss on speech recognition under distracting conditions and working memory in the elderly.
    Clin Interv Aging 2017 1;12:1175-1181. Epub 2017 Aug 1.
    Division of Speech Pathology and Audiology, Research Institute of Audiology and Speech Pathology, College of Natural Sciences, Hallym University, Chuncheon, Republic of Korea.
    Purpose: The current study aimed to evaluate hearing-related changes in terms of speech-in-noise processing, fast-rate speech processing, and working memory; and to identify which of these three factors is significantly affected by age-related hearing loss.

    Methods: One hundred subjects aged 65-84 years participated in the study. They were classified into four groups ranging from normal hearing to moderate-to-severe hearing loss. Read More

    BFH-OSTM, a new predictive screening tool for identifying osteoporosis in elderly Han Chinese males.
    Clin Interv Aging 2017 31;12:1167-1174. Epub 2017 Jul 31.
    Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, People's Republic of China.
    Purpose: To develop and validate a new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA) in two elderly Han Chinese male populations.

    Methods: A cross-sectional study was conducted, enrolling 1,870 community-dwelling and 574 hospital-checkup elderly Han Chinese males aged ≥50 years. All subjects completed a structured questionnaire and had their bone mineral density (BMD) measured using DXA. Read More

    Use of care and the oral health status of people aged 60 years and older in France: results from the National Health and Disability Survey.
    Clin Interv Aging 2017 31;12:1159-1166. Epub 2017 Jul 31.
    UMR 7268 ADÉS, Aix-Marseille Université-EFS-CNRS, Faculté de Médecine Nord.
    Objective: We aimed to analyze, from the data in a national survey, the use of oral care and the oral health status of patients living at home or in an institution.

    Background: Patients aged 60 years and older have important oral health needs, but their oral management may differ according to their immediate environment. The fact of living at home or in an institution can influence the use of care and alter the patients' perception of their oral health status. Read More

    Grip strength as a frailty diagnostic component in geriatric inpatients.
    Clin Interv Aging 2017 26;12:1151-1157. Epub 2017 Jul 26.
    Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
    Background: Frailty has emerged as a key medical syndrome predictive of comorbidity, disability, institutionalization and death. As a component of the five frailty phenotype diagnostic criteria, patient grip strength deserves attention as a simple and objective measure of the frailty syndrome. The aim of this study was to assess conditions that influence grip strength in geriatric inpatients. Read More

    Promoting ADL independence in vulnerable, community-dwelling older adults: a pilot RCT comparing 3-Step Workout for Life versus resistance exercise.
    Clin Interv Aging 2017 19;12:1141-1149. Epub 2017 Jul 19.
    Indiana University Center for Aging Research.
    Background: Resistance exercise is effective to increase muscle strength for older adults; however, its effect on the outcome of activities of daily living is often limited. The purpose of this study was to examine whether 3-Step Workout for Life (which combines resistance exercise, functional exercise, and activities of daily living exercise) would be more beneficial than resistance exercise alone.

    Methods: A single-blind randomized controlled trial was conducted. Read More

    Lower serum P1NP/βCTX ratio and hypoalbuminemia are independently associated with osteoporotic nonvertebral fractures in older adults.
    Clin Interv Aging 2017 19;12:1131-1140. Epub 2017 Jul 19.
    Department of Orthopaedic Surgery, The Canberra Hospital, ACT Health, Canberra, Australia.
    Purpose: To estimate the discriminative value of serum P1NP/βCTX ratio and albumin levels in hospitalized orthogeriatric patients with and without nonvertebral fractures.

    Methods: In 1,239 orthogeriatric patients (mean age 78.1±9. Read More

    Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting.
    Clin Interv Aging 2017 14;12:1123-1129. Epub 2017 Jul 14.
    Department of Cardiac Surgery.
    Background: Preoperative spirometry provides measurable information about the occurrence of respiratory disorders. The aim of this study was to assess the association between preoperative spirometry abnormalities and the intensification of early inflammatory responses in patients following coronary artery bypass graft in extracorporeal circulation.

    Material And Methods: The study involved 810 patients (625 men and 185 women) aged 65. Read More

    Increased neutrophil-lymphocyte ratio in delirium: a pilot study.
    Clin Interv Aging 2017 14;12:1115-1121. Epub 2017 Jul 14.
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
    Aim: Delirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil-lymphocyte ratio (NLR) - a marker of systemic inflammation and oxidative stress - in patients with and without delirium. Read More

    Acute effects of power and resistance exercises on hemodynamic measurements of older women.
    Clin Interv Aging 2017 11;12:1103-1114. Epub 2017 Jul 11.
    Applied Kinesiology Laboratory-LCA, School of Physical Education, University of Campinas, Barão Geraldo, Campinas, São Paulo.
    Purpose: The purpose of this study was to compare the acute effects of resistance training (RT) and power training (PT) on the hemodynamic parameters and nitric oxide (NO) bioavailability of older women.

    Materials And Methods: A randomized experimental design was used in this study. Twenty-one older women (age: 67. Read More

    Apolipoprotein ε7 allele in memory complaints: insights through protein structure prediction.
    Clin Interv Aging 2017 11;12:1095-1102. Epub 2017 Jul 11.
    Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul.
    Purpose: APOE ε7 gene is a rare mutant form of APOE ε3. The mutation occurs in the lipid-binding domain of APOE. Based on the protein's structure, APOE ε7 is expected to function in lipid and β-amyloid metabolism, similar to APOE ε4. Read More

    Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report.
    Clin Interv Aging 2017 11;12:1089-1093. Epub 2017 Jul 11.
    Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan, Taiwan.
    Bisphosphonates (BPs) suppress bone resorption and increase bone strength, thus reducing the risk of fracture. Oral BPs are widely used for the prevention and treatment of osteoporosis and osteopenia. Here, we describe the case of a postmenopausal woman who took oral alendronate for >3 years for osteoporosis. Read More

    The long-term effects of the health coaching self-management program for nursing-home residents.
    Clin Interv Aging 2017 11;12:1079-1088. Epub 2017 Jul 11.
    College of Nursing, Seoul National University.
    Background And Aims: Little is known about whether a self-management program for nursing-home residents (NHR) with cognitive impairment is likely to have an impact on the care of this growing population. This study aimed to evaluate the effects of the health-coaching self-management program for NHR (HCSMP-NHR) on 1) self-efficacy and goal attainment scaling (GAS), 2) health status and quality of life (QoL) among older people, including those with cognitive impairment, in Korean nursing homes.

    Methods: This was a cluster-randomized controlled trial. Read More

    Pharmacological treatment of osteoporosis in the oldest old.
    Clin Interv Aging 2017 6;12:1065-1077. Epub 2017 Jul 6.
    Center for Metabolic Bone Disease, UZ Leuven.
    The incidence of osteoporotic fractures increases with age. Consequently, the global prevalence of osteoporotic fractures will increase with the aging of the population. In old age, osteoporosis is associated with a substantial burden in terms of morbidity and mortality. Read More

    Influence of environmental factors on food intake among nursing home residents: a survey combined with a video approach.
    Clin Interv Aging 2017 4;12:1055-1064. Epub 2017 Jul 4.
    Department of Public Health, Epidemiology and Health Economics, University of Liège.
    Background: In addition to the well-known physiological factors, dietary behavior that affects health seems to be influenced by a wide variety of environmental factors. The aim of this study was to assess, by means of an original video approach, the influence of the environment on food intake in nursing homes.

    Methods: The perception of the environment during meals in nursing homes was evaluated by residents and by two groups of volunteers who either work in the field of geriatrics, or who do not work in the field of geriatrics. Read More

    Kidney function and cognitive decline in an oldest-old Chinese population.
    Clin Interv Aging 2017 4;12:1049-1054. Epub 2017 Jul 4.
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
    Background: Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old.

    Subjects And Methods: This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The median follow-up time was 3. Read More

    (11)C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia.
    Clin Interv Aging 2017 29;12:1041-1048. Epub 2017 Jun 29.
    Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea.
    Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.

    Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone (11)C-labeled Pittsburgh compound B-positron emission tomography imaging. Read More

    Operationalizing a frailty index using routine blood and urine tests.
    Clin Interv Aging 2017 28;12:1029-1040. Epub 2017 Jun 28.
    Institute for Biomedicine of Ageing (IBA), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Nuremberg, Germany.
    Background: Uncomplicated frailty instruments are desirable for use in a busy clinical setting. The aim of this study was to operationalize a frailty index (FI) from routine blood and urine tests, and to evaluate the properties of this FI compared to other frailty instruments.

    Materials And Methods: We conducted a secondary analysis of a prospective cohort study on 306 patients aged ≥65 years hospitalized on geriatric wards. Read More

    Regular physical exercise improves cardiac autonomic and muscle vasodilatory responses to isometric exercise in healthy elderly.
    Clin Interv Aging 2017 28;12:1021-1028. Epub 2017 Jun 28.
    Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.
    The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver). Read More

    The impact of transient and persistent acute kidney injury on short-term outcomes in very elderly patients.
    Clin Interv Aging 2017 28;12:1013-1020. Epub 2017 Jun 28.
    Department of Geriatric Nephrology.
    Objectives: Acute kidney injury (AKI) is a common complication in elderly patients and is associated with poor outcomes. However, the effect of transient and persistent geriatric AKI on short-term mortality is unclear. We aimed to study the incidence, clinical characteristics, and prognostic impact of transient and persistent AKI in such patients. Read More

    Frailty in community-dwelling older adults: association with adverse outcomes.
    Clin Interv Aging 2017 26;12:1003-1011. Epub 2017 Jun 26.
    Epidemiology and Health Services Research Unit, Aging Area, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social.
    Background: The study of frailty is important to identify the additional needs of medical long-term care and prevent adverse outcomes in community dwelling older adults. This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults.

    Methods: A cross-sectional study was carried out from April to September 2014. Read More

    Frequency of frailty and its association with cognitive status and survival in older Chileans.
    Clin Interv Aging 2017 26;12:995-1001. Epub 2017 Jun 26.
    Faculty of Medicine, Clinical Hospital, University of Chile, Santiago, Chile.
    Background: Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability.

    Objective: To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans.

    Methods: Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. Read More

    A community virtual ward model to support older persons with complex health care and social care needs.
    Clin Interv Aging 2017 26;12:985-993. Epub 2017 Jun 26.
    School of Nursing and Midwifery, Royal College of Surgeons Ireland.
    Background: Globally the older population is increasing rapidly. As a result there is an increase in frail older persons living within the community, with increased risks of a hospital admission and higher mortality and morbidity rates. Due to complexity of care, health care professionals face challenges in providing effective case management and avoiding unplanned admissions to hospital. Read More

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