1,790 results match your criteria Clinical Interventions in Aging[Journal]


Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea.

Clin Interv Aging 2019 31;14:241-247. Epub 2019 Jan 31.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan,

Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).

Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. Read More

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http://dx.doi.org/10.2147/CIA.S193448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362916PMC
January 2019

Investigating dose-response effects of multimodal exercise programs on health-related quality of life in older adults.

Clin Interv Aging 2019 24;14:209-217. Epub 2019 Jan 24.

Department of Medicine, University of Montreal, Montreal, Quebec, Canada,

Background: Older adults are at risk of multiple chronic diseases, most of which could be prevented by engaging in regular physical activity. Frailty is a state of increased vulnerability to diseases. Worsening symptoms of frailty, such as decrease in physical functionality, can compromise health-related quality of life (HR-QOL). Read More

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https://www.dovepress.com/investigating-dosendashresponse-ef
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http://dx.doi.org/10.2147/CIA.S187534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352872PMC
January 2019
1 Read

Feasibility and efficacy of enhanced recovery after surgery protocol in Chinese elderly patients with intracranial aneurysm.

Clin Interv Aging 2019 23;14:203-207. Epub 2019 Jan 23.

Department of Neurosurgery, Inner Mongolia Xing'an Meng People's Hospital, Ulanhot 137400, China,

Objective: Intracranial aneurysm is a kind of severe intracranial disease mainly responsible for subarachnoid hemorrhage, and the rupture of intracranial aneurysm results in a mortality rate of 30%-40%. For the first time in the world, this study aimed to assess the feasibility and efficacy of enhanced recovery after surgery (ERAS) protocol in Chinese elderly patients with intracranial aneurysm.

Methods: In this study, 300 elderly patients with intracranial aneurysm were recruited and divided into two groups as follows: ERAS group (n=150, ERAS protocol) and control group (n=150, conventional management). Read More

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http://dx.doi.org/10.2147/CIA.S187967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350647PMC
January 2019
1 Read

Acute kidney injury after transcatheter aortic valve replacement in the elderly: outcomes and risk management.

Clin Interv Aging 2019 21;14:195-201. Epub 2019 Jan 21.

Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland,

Aortic stenosis is the most common cause of valve replacement in Europe and North America with prevalence increasing with age. Transcatheter valve replacement (TAVR) represents an alternative for surgical valve replacement of severely stenotic valves. Despite lower risk of acute kidney injury compared to that associated with surgery, this complication remains prevalent in patients undergoing TAVR. Read More

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http://dx.doi.org/10.2147/CIA.S149916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345183PMC
January 2019
2 Reads

Illness representations of dementia: a scoping review.

Clin Interv Aging 2019 18;14:179-193. Epub 2019 Jan 18.

Department of Community Mental Health, University of Haifa, Haifa, Israel.

As the number of persons with dementia grows, an increasing number of families, professionals, and laypersons will come into contact with persons with cognitive deterioration. Assessing dementia illness representations (IRs) among these groups may have great importance for understanding their responses to dementia. The purpose of this study was to summarize and critically review the literature on dementia IRs. Read More

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http://dx.doi.org/10.2147/CIA.S193316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342146PMC
January 2019

Carotid artery calcification score and its association with cognitive impairment.

Clin Interv Aging 2019 18;14:167-177. Epub 2019 Jan 18.

Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China,

Purpose: To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impairment in carotid artery stenosis (CAS) patients.

Patients And Methods: Carotid artery was measured in 102 patients with cervical carotid arteries using Color Doppler ultrasound, multi-detector row spiral CT angiography and MRI scanning. Correlation analysis between CSs obtained by MD CT and cognitive scores was performed, and the correlation between CSs and vascular stenosis degree and MRI-measured plaque histological (lipid-rich necrotic nucleus [LRNC], intraplaque hemorrhage and fibrous cap surface rupture) and morphological parameters (lumen area [LA], wall area [WA], total area of blood vessels [TVA], plaque burden [PB]) was analyzed. Read More

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http://dx.doi.org/10.2147/CIA.S192586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342141PMC
January 2019
4 Reads

The relationship between sleep disturbances and quality of life in elderly patients with hypertension.

Clin Interv Aging 2019 15;14:155-165. Epub 2019 Jan 15.

Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, 51-618 Wroclaw, Poland.

Purpose: Sleep disorders, such as insomnia with objective short sleep duration, are associated with increased risk of hypertension. The objective of the study was to evaluate the effects of insomnia and daytime sleepiness on the quality of life (QOL) among elderly hypertensive patients.

Patients And Methods: This cross-sectional study covered 100 patients with hypertension. Read More

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http://dx.doi.org/10.2147/CIA.S188499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339653PMC
January 2019
1 Read

Effects of a fall prevention program in elderly: a pragmatic observational study in two orthopedic departments.

Clin Interv Aging 2019 15;14:145-154. Epub 2019 Jan 15.

Department of Research, Innlandet Hospital Trust, Brumunddal, Norway,

Purpose: Falls are a common adverse event experienced by elderly in hospitals. This study assessed the effects of a fall prevention program on the rate of fallers, the patient safety culture, and patient-perceived safety.

Materials And Methods: Two orthopedic departments in different towns in Norway participated in the study. Read More

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https://www.dovepress.com/effects-of-a-fall-prevention-progr
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http://dx.doi.org/10.2147/CIA.S191832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339647PMC
January 2019
3 Reads

Transtrochanteric approach can provide better postoperative care and lower complication rate in the treatment of hip fractures.

Clin Interv Aging 2019 14;14:137-143. Epub 2019 Jan 14.

Department of Orthopedics and Traumatology, Ankara Yildirim Beyazit University, Ankara 06800, Turkey,

Purpose: Dislocation is an important complication that increases the mortality, morbidity, and postoperative care following bipolar hemiarthroplasty. It is thought that the transtrochanteric approach that enables access to the femoral neck directly from the fracture line at the coronal plane of the greater trochanter without opening the posterior and anterior capsules could reduce the risk of dislocation. Additionally, it is argued that preservation of the external rotators could also be advantageous for patient rehabilitation and muscle strength. Read More

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http://dx.doi.org/10.2147/CIA.S194880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336027PMC
January 2019
5 Reads

The cognitive and psychosocial effects of auditory training and hearing aids in adults with hearing loss.

Clin Interv Aging 2019 11;14:123-135. Epub 2019 Jan 11.

Cochlear Center for Hearing and Public Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Purpose: Our study assessed the efficacy of the simultaneous use of hearing aids and auditory training for improving cognition and psychosocial function in adults with hearing loss, and the relationships between hearing loss, speech perception and cognition.

Participants And Methods: A 40-person (aged 50-90 years) pilot study in Melbourne, Australia, was conducted. Participants with hearing impairment completed the Geriatric Depression Scale-Short Form, questions about social activity participation, a wide range of cognitive tasks and a speech perception test at baseline, 3 and 6 months. Read More

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http://dx.doi.org/10.2147/CIA.S183905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331065PMC
January 2019
1 Read

Does the Meeting Centres Support Programme reduce unmet care needs of community-dwelling older people with dementia? A controlled, 6-month follow-up Polish study.

Clin Interv Aging 2019 11;14:113-122. Epub 2019 Jan 11.

Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.

Introduction: In Poland we lack a multidisciplinary and coordinated system of care for people with dementia, which would take the form of an evidence-based pathway and the number of reports on the holistic approach to caring for people living with this diagnosis is very low.

Aim Of The Study: The aim of the study was to investigate whether the Meeting Centres Support Programme (MCSP) is effective in meeting the needs of older people with dementia.

Participants And Methods: This was done by comparing the experiences of people with dementia themselves and that of their carers at baseline and at follow-up, after 6 months of participation in MCSP or Usual Care (UC). Read More

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https://www.dovepress.com/does-the-meeting-centres-support-p
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http://dx.doi.org/10.2147/CIA.S185683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331064PMC
January 2019
4 Reads

Relationship between nutritional status and frailty in hospitalized older patients.

Clin Interv Aging 2019 10;14:105-111. Epub 2019 Jan 10.

Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People's Republic of China,

Objective: The definition of frailty still lacks quantitative biomarkers. This study aimed to investigate the relationship between nutrition-related biomarkers and frailty in hospitalized older patients.

Materials And Methods: This is a cross-sectional study including 380 hospitalized older patients. Read More

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http://dx.doi.org/10.2147/CIA.S189040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330965PMC
January 2019
1 Read

Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis.

Clin Interv Aging 2019 3;14:91-104. Epub 2019 Jan 3.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China,

Purpose: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis.

Methods: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Read More

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https://www.dovepress.com/tai-chi-for-treating-osteopenia-an
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http://dx.doi.org/10.2147/CIA.S187588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322510PMC
January 2019
5 Reads

Comparison of prognostic values of high-sensitivity cardiac troponin T and N-terminal prohormone brain natriuretic peptide to assess mortality in elderly inpatients.

Clin Interv Aging 2019 31;14:81-90. Epub 2018 Dec 31.

Department of Geriatrics, Fuxing Hospital, affiliated to Capital Medical University, Beijing, China,

Background: Studies have shown that increases in low-level high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) in the elderly population lead to high risk of adverse clinical outcomes, such as mortality. In this study, associations between the two biomarkers and long-term mortality in elderly patients hospitalized for medical conditions other than acute cardiovascular events were investigated. A comparison of the predictive value of hs-cTnT and NT-proBNP for all-cause mortality was conducted. Read More

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http://dx.doi.org/10.2147/CIA.S187757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318716PMC
December 2018
1 Read

RAB10: an Alzheimer's disease resilience locus and potential drug target.

Clin Interv Aging 2019 28;14:73-79. Epub 2018 Dec 28.

Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA,

Alzheimer's disease (AD) is mainly a late-onset neurodegenerative disorder. Substantial efforts have been made to solve the complex genetic architecture of AD as a means to identify therapeutic targets. Unfortunately, to date, no disease-altering therapeutics have been developed. Read More

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http://dx.doi.org/10.2147/CIA.S159148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312396PMC
December 2018
2 Reads

Comparison of three criteria for potentially inappropriate medications in Chinese older adults.

Clin Interv Aging 2019 28;14:65-72. Epub 2018 Dec 28.

Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China,

Objectives: This study aimed to compare the prevalence of potentially inappropriate medications (PIMs) among Chinese aged patients using the Beers criteria of 2015, the Screening Tool of Older Persons' Prescriptions (STOPP) of 2014 and the criteria of PIMs for older adults in China (Chinese criteria), and to identify the correlates of the PIMs' use.

Methods: A retrospective, cross-sectional study was conducted among geriatric patients at Beijing Chao-Yang Hospital between January 2018 and March 2018. Three criteria (the Beers criteria of 2015, the STOPP criteria of 2014 and the Chinese criteria) were used to detect PIMs. Read More

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http://dx.doi.org/10.2147/CIA.S190983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312397PMC
December 2018
1 Read

Influence of diabetes mellitus on anterior segment of the eye.

Clin Interv Aging 2019 27;14:53-63. Epub 2018 Dec 27.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Diabetes mellitus (DM) has been emerging as one of the most serious health problems worldwide. Ocular complications of DM are currently one of the major causes of blindness in developed countries, among which diabetic retinopathy is relatively well studied and understood. However, although ocular surface complications of DM are common, diabetic complications of anterior segment of the eye, such as, cornea, conjunctiva, and lacrimal glands, are often overlooked. Read More

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http://dx.doi.org/10.2147/CIA.S190713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312050PMC
December 2018
8 Reads

Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation.

Clin Interv Aging 2019 24;14:43-51. Epub 2018 Dec 24.

Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.

Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Read More

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http://dx.doi.org/10.2147/CIA.S183425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307498PMC
February 2019
6 Reads

Elderly persons with acute pancreatitis - specifics of the clinical course of the disease.

Clin Interv Aging 2019 21;14:33-41. Epub 2018 Dec 21.

Faculty of Medicine and Health Sciences, The Jan Kochanowski University, Kielce, Poland,

Background: As may readily be inferred from clinical observations, there is an increasing prevalence of severe acute pancreatitis (SAP) in the elderly, even though the precise nature of the relationship between a patient's age and severity of the disease has not been unequivocally determined to date. This study aimed therefore to investigate the incidence, clinical course, and mortality rate among the elderly patients suffering from acute pancreatitis (AP), as compared to younger ones.

Methods: A prospective study, lasting a single calendar year, covered patients with AP successively admitted to hospitals. Read More

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http://dx.doi.org/10.2147/CIA.S188520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306050PMC
February 2019
2 Reads

Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study.

Clin Interv Aging 2019 20;14:27-32. Epub 2018 Dec 20.

Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,

Introduction: Few studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months.

Methodology: Mini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. Read More

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https://www.dovepress.com/mild-cognitive-impairment-in-maint
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http://dx.doi.org/10.2147/CIA.S178854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304252PMC
February 2019
7 Reads

Understanding experiences of patients and family caregivers in the Mayo Clinic Care Transitions program: a qualitative study.

Clin Interv Aging 2019 19;14:17-25. Epub 2018 Dec 19.

Robert D and Patricia E Kern Center for Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Background: Care transitions programs are increasingly used to improve care and reduce re-admission of patients after hospitalization. To learn from the experience of patients who have participated in the Mayo Clinic Care Transitions (MCCT) program and to understand the patient experience, we sought perspectives of patients, caregivers, and providers who worked with participants of the MCCT program.

Methods: Investigators interviewed 17 patients and nine of their caregivers about their experience with the MCCT program. Read More

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https://www.dovepress.com/understanding-experiences-of-patie
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http://dx.doi.org/10.2147/CIA.S183893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304078PMC
February 2019
6 Reads

Using the Borg rating of perceived exertion scale to grade the intensity of a functional training program of the affected upper limb after a stroke: a feasibility study.

Clin Interv Aging 2019 19;14:9-16. Epub 2018 Dec 19.

University of Sherbrooke, School of Medicine and Health Sciences, School of Rehabilitation, Research Center on Aging, Sherbrooke, Québec, Canada,

Purpose: Intensity of a training program is a critical variable in treatment gains poststroke, but there are no guidelines to adequately dose the intensity of functional training (FT); the recommended type of training to promote poststroke recovery. Such guidelines are made available for strength training (ST) using the 1 repetition maximum (1RM), which has been linked to individuals' self-rated level of exertion using the Borg rating of perceived exertion (BRPE) scale. The BRPE could be a valuable tool for clinicians to dose FT intensity after a stroke, but this remains to be tested. Read More

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http://dx.doi.org/10.2147/CIA.S179691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304074PMC
February 2019
1 Read

COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure.

Clin Interv Aging 2019 18;14:1-8. Epub 2018 Dec 18.

Clinical Pharmacology, Institute of Infection and Immunity, St George's University of London, London, UK,

Purpose: People with COPD have cognitive dysfunction, which is greater in those hospitalized for exacerbations than in stable outpatients. We tested the hypothesis that cognitive dysfunction at exacerbation is a disease-specific feature of COPD, rather than a nonspecific feature of hospitalization for acute illness, by comparing cognition between patients hospitalized for acute COPD exacerbations and those with worsening heart failure (HF).

Patients And Methods: A total of 40 hospital inpatients were recruited, 20 patients with COPD exacerbations and 20 patients with congestive or left-sided HF. Read More

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http://dx.doi.org/10.2147/CIA.S185981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302823PMC
February 2019
4 Reads

Clinical effects of the bridge-type ROI-C interbody fusion cage system in the treatment of cervical spondylosis with osteoporosis.

Clin Interv Aging 2018 14;13:2543-2551. Epub 2018 Dec 14.

Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China,

Objective: To investigate the early and mid-term efficacy and safety of the bridge-type ROI-C interbody fusion cage system in the treatment of cervical spondylosis with osteoporosis during anterior cervical discectomy and fusion (ACDF).

Patients And Methods: The clinical data from 24 cervical spondylosis patients with osteoporosis treated with ACDF were retrospectively analyzed. All patients were treated with ROI-C cage. Read More

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http://dx.doi.org/10.2147/CIA.S182969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298882PMC
February 2019
4 Reads

Statistical concerns about the study: "Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study".

Clin Interv Aging 2018 14;13:2539-2542. Epub 2018 Dec 14.

Istanbul Physical Medicine and Rehabilitation Training Hospital, Department of Physical Therapy and Rehabilitation, Bahcelievler 34188, Istanbul, Turkey.

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http://dx.doi.org/10.2147/CIA.S192184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298878PMC
January 2019
2 Reads

Integrated health care systems in Asia: an urgent necessity.

Clin Interv Aging 2018 14;13:2527-2538. Epub 2018 Dec 14.

Medical affairs, Pfizer Essential Health CMO Organization, Kuala Lumpur, Malaysia,

A rapidly aging population along with the increasing burden of patients with chronic conditions in Asia requires efficient health systems with integrated care. Although some efforts to integrate primary care and hospital care in Asia are underway, overall care delivery remains fragmented and diverse, eg, in terms of medical electronic record sharing and availability, patient registries, and empowerment of primary health care providers to handle chronic illnesses. The primary care sector requires more robust and effective initiatives targeted at specific diseases, particularly chronic conditions such as diabetes, hypertension, depression, and dementia. Read More

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https://www.dovepress.com/integrated-health-care-systems-in-
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http://dx.doi.org/10.2147/CIA.S185048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298881PMC
February 2019
9 Reads

Age should not be a limiting factor in laparoscopic surgery: a prospective multicenter cohort study on quality of life after laparoscopic hysterectomy.

Clin Interv Aging 2018 13;13:2517-2526. Epub 2018 Dec 13.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Purpose: A prospective, multicenter cohort study was performed on the implementation of laparoscopic hysterectomy (LH) in the Netherlands. The aim of this study was to evaluate the impact of LH on quality of life (QOL) with respect to age up to 6 months postoperatively.

Patients And Methods: Women with an indication for LH, either for benign conditions or early-stage low-risk endometrial cancer were included. Read More

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http://dx.doi.org/10.2147/CIA.S172965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296188PMC
February 2019
3 Reads

Cognitive status and use of analgesics and anxiolytics in residents of nursing homes in the Czech Republic.

Clin Interv Aging 2018 11;13:2511-2515. Epub 2018 Dec 11.

Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic,

Background: The treatment of pain and treatment of anxiety are two of the most complex issues in nursing homes worldwide, mainly because of the large numbers of people with cognitive impairment who reside in this environment.

Aim: The aim of this study was to investigate the administration of analgesics and anxiolytics to people living in nursing homes, taking into account cognitive status.

Methods: For this cross-sectional study, we used data from 404 residents who lived in nine randomly selected nursing homes in the Czech Republic and participated in the Czech-Austrian Long-Term Care Research Project called DEMDATA. Read More

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http://dx.doi.org/10.2147/CIA.S188601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294074PMC
February 2019
8 Reads

Age and recurrent stroke are related to the severity of white matter hyperintensities in lacunar infarction patients with diabetes.

Clin Interv Aging 2018 7;13:2487-2494. Epub 2018 Dec 7.

Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China,

Background And Purpose: White matter hyperintensities (WMH) is identified as a marker of cerebral small vessel diseases and is a major contributor to cognitive impairment, depression, gait disturbance, and urinary incontinence. However, the risk factors for WMH in patients with type 2 diabetes mellitus (T2DM) has not been well explored. Thus, in this study, we aimed to investigate the relationship between the severity of WMH and vascular risk factors in lacunar infarction patients with T2DM. Read More

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https://www.dovepress.com/age-and-recurrent-stroke-are-relat
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http://dx.doi.org/10.2147/CIA.S184463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290865PMC
February 2019
7 Reads

Relationship between clinical outcomes and Dutch frailty score among elderly patients who underwent surgery for hip fracture.

Clin Interv Aging 2018 5;13:2481-2486. Epub 2018 Dec 5.

Department of Geriatrics, Isala, 8025 AB, Zwolle, the Netherlands,

Background: Frailty is a geriatric condition that is associated with an increased risk of mortality and functional decline. To date, mainly the Groningen Frailty Indicator (GFI) and Hospital Safety Management (VeiligheidsManagementSysteem [VMS]) frailty score are used to determine frailty in several hospitals in the Netherlands. However, it is yet unknown, which method has the best predictive value on clinical outcomes. Read More

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http://dx.doi.org/10.2147/CIA.S181497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287424PMC
February 2019
2 Reads

A randomized-controlled trial pilot study examining the effect of extracorporeal magnetic innervation in the treatment of stress urinary incontinence in women.

Clin Interv Aging 2018 4;13:2473-2480. Epub 2018 Dec 4.

Department of Physiotherapy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland,

Introduction: Peri- and postmenopausal women frequently suffer from urinary incontinence (UI). Generally, UI becomes more severe with age. It impacts physical, mental, and social functioning as well as the quality of life, often leading to depression. Read More

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http://dx.doi.org/10.2147/CIA.S176588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287547PMC
February 2019
1 Read

Health-related quality of life in Romanian postmenopausal women with osteoporosis and fragility fractures.

Clin Interv Aging 2018 3;13:2465-2472. Epub 2018 Dec 3.

Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Objectives: Osteoporosis is a common skeletal disorder characterized by decreased bone mass and increased susceptibility to fractures, which are associated with pain and decrease in physical function, social function, and well-being, which are all aspects of quality of life (QoL). The purpose of this study was to evaluate the burden of osteoporosis and fragility fractures in Romanian postmenopausal women from Cluj County using the 36-Item Short Form Health Survey (SF-36) and Quality of life questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) questionnaires.

Materials And Methods: An analytical cross-sectional study on 364 postmenopausal women was carried out between June 2016 and August 2017 in the Clinical Rehabilitation Hospital in Cluj-Napoca, Cluj County, Romania. Read More

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http://dx.doi.org/10.2147/CIA.S190440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284528PMC
February 2019
3 Reads

Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study.

Clin Interv Aging 2018 10;13:2503-2509. Epub 2018 Dec 10.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China,

Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Read More

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https://www.dovepress.com/association-between-vitamin-d-stat
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http://dx.doi.org/10.2147/CIA.S187142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292227PMC
February 2019
5 Reads

Trainability of leg strength by whole-body electromyostimulation during adult lifespan: a study with male cohorts.

Clin Interv Aging 2018 10;13:2495-2502. Epub 2018 Dec 10.

Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany,

Background: The age-related decline in muscle strength is a well documented phenomenon in human beings. Resistance-type exercise including the novel, joint-friendly, and time-efficient whole-body electromyostimulation (WB-EMS) technology decelerates this unfavorable decline. However, the issue of trainability of the neuromuscular system during different periods of life still remains, especially for WB-EMS. Read More

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http://dx.doi.org/10.2147/CIA.S185018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292245PMC
February 2019
1 Read

The good, the bad, and the ugly of calcium supplementation: a review of calcium intake on human health.

Clin Interv Aging 2018 28;13:2443-2452. Epub 2018 Nov 28.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA 70112, USA,

Calcium is an important integrative component of the human body and critical for human health. It has been well established that calcium intake is helpful in the prevention and treatment of osteoporosis, which has become one of the most serious public health problems across the world. However, community-dwelling adults with and without osteoporosis are rarely concerned or even not aware of the potential side effects of high or inappropriate doses of calcium intake. Read More

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https://www.dovepress.com/the-good-the-bad-and-the-ugly-of-c
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http://dx.doi.org/10.2147/CIA.S157523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276611PMC
February 2019
9 Reads

Factors influencing adherence to treatment in older adults with hypertension.

Clin Interv Aging 2018 28;13:2425-2441. Epub 2018 Nov 28.

Department of Physiological Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA.

Purpose: Hypertension (HT) is considered to be the most common disorder in the general population. Demographic data indicate that older adults commonly suffer from HT. Older age is one of the key factors affecting the adherence of patients with HT. Read More

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http://dx.doi.org/10.2147/CIA.S182881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276633PMC
February 2019
6 Reads

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes in an older adult mimicking cerebral infarction: a Chinese case report.

Clin Interv Aging 2018 27;13:2421-2424. Epub 2018 Nov 27.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China,

Few cases of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) with an onset older than 60 years have been reported. Herein, we report a 63-year-old Chinese female initially suspected of ischemic infarction but was ultimately diagnosed with MELAS. Therefore, even in the elderly, a diagnosis of MELAS should be considered when encountering patients with recurrent stroke-like episodes, cognitive dysfunction, and psychotic symptoms. Read More

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https://www.dovepress.com/mitochondrial-encephalomyopathy-wi
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http://dx.doi.org/10.2147/CIA.S186636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267726PMC
January 2019
7 Reads

Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals.

Clin Interv Aging 2018 30;13:2453-2464. Epub 2018 Nov 30.

Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil,

Introduction: Population aging generally accompanies an increase in chronic noncommunicable diseases, such as metabolic syndrome (MS). Nursing homes have provided a solution for the decreased ability of elderly individuals for self-care and familial difficulties in meeting the health care needs of elderly individuals.

Purpose: The aim of the present study was to determine the frequency of MS and its associated factors in elderly individuals living in nursing homes. Read More

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http://dx.doi.org/10.2147/CIA.S177731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280900PMC
February 2019
2 Reads

Role of miRNAs in skeletal muscle aging.

Clin Interv Aging 2018 22;13:2407-2419. Epub 2018 Nov 22.

Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, Jilin, China,

Purpose: The aim of this study was to explore the role of miRNAs in the process of skeletal muscle aging.

Materials And Methods: We analyzed the miRNA microarray datasets from 19 young and 17 old skeletal muscle samples by bioinformatic analysis. Differentially expressed miRNAs were identified, followed by function and pathway enrichment analysis. Read More

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http://dx.doi.org/10.2147/CIA.S169202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254589PMC
January 2019
2 Reads
1.824 Impact Factor

Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment.

Clin Interv Aging 2018 21;13:2397-2406. Epub 2018 Nov 21.

Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, ACT, Australia,

Background: With no cure for dementia and the number of people living with the condition predicted to rapidly rise, there is an urgent need for dementia risk reduction and prevention interventions. Modifiable lifestyle risk factors have been identified as playing a major role in the development of dementia; hence, interventions addressing these risk factors represent a significant opportunity to reduce the number of people developing dementia. Relatively few interventions have been trialed in older participants with cognitive decline (secondary prevention). Read More

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https://www.dovepress.com/body-brain-life-for-cognitive-decl
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http://dx.doi.org/10.2147/CIA.S182046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254686PMC
January 2019
10 Reads

Needs of older adults living in long-term care institutions: an observational study using Camberwell Assessment of Need for the Elderly.

Clin Interv Aging 2018 21;13:2389-2395. Epub 2018 Nov 21.

Laboratory of Neuropsychobiology, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: No comprehensive needs assessment is performed routinely in Poland.

Purpose: The goal of the study was to investigate the patterns of needs in older individuals living in long-term care institutions (LTCIs) using the Camberwell Assessment of Need for the Elderly (CANE) questionnaire, based on a previously published study protocol.

Participants And Methods: The study included 306 LTCI residents (age: ≥75 years) with the a Mini-Mental State Examination (MMSE) score of at least 10 points. Read More

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http://dx.doi.org/10.2147/CIA.S145937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254588PMC
January 2019
1 Read

American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients.

Clin Interv Aging 2018 19;13:2375-2387. Epub 2018 Nov 19.

Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa,

Background: The Beers Criteria were developed with the aim of improving the safety of medicines among older persons. While the association between the Beers' list of potentially inappropriate medicines (PIMs) and adverse drug reactions (ADRs) among older Caucasians is contentious, the ability of the Criteria to predict ADRs among older persons in Africa remains unexplored.

Objectives: This study aimed to compare the prevalence of PIMs and ADRs among hospitalized older persons in Nigeria and South Africa, and to determine the association between the 2015 American Geriatrics Society-Beers (AGS-Beers) PIMs and ADRs. Read More

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http://dx.doi.org/10.2147/CIA.S176899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251468PMC
January 2019
2 Reads

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol.

Clin Interv Aging 2018 16;13:2367-2374. Epub 2018 Nov 16.

National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China,

Objective: This study aimed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 (FGF-23), sclerostin, intact parathyroid hormone (PTH), and handgrip strength in postmenopausal women with low bone mass.

Methods: A randomized, double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass. Participants were randomized into two groups: 75 participants received calcitriol 0. Read More

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http://dx.doi.org/10.2147/CIA.S186199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247960PMC
January 2019
2 Reads

Aortic remodeling in Type B aortic dissection after thoracic endovascular aortic repair with an aortic extender cuff implantation.

Clin Interv Aging 2018 15;13:2359-2366. Epub 2018 Nov 15.

Department of Vascular Surgery, Gulou Clinical College of Nanjing Medical University, Nanjing 210000, Jiangsu, China,

Objective: This study investigated the safety and efficiency of thoracic endovascular aortic repair (TEVAR) plus an aortic extender cuff placement in treating Stanford Type B aortic dissections (TBADs).

Methods: Clinical data on 157 patients with TBADs who underwent TEVAR in two tertiary medical centers from February 2013 to March 2018 were analyzed retrospectively. An estimated mismatch rate >120% was the indication for placement of an aortic extender cuff. Read More

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http://dx.doi.org/10.2147/CIA.S179526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241866PMC
January 2019
1 Read

Determining functional activity profiles in patients with upper extremity disorders: is there effect modification by hand-grip strength?

Clin Interv Aging 2018 15;13:2351-2358. Epub 2018 Nov 15.

Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Republic of Korea,

Purpose: The purposes of this study were to investigate the effect of hand-grip strength (HGS) on the Disabilities of the Arm, Shoulder, and Hand (DASH) score in women with upper extremity musculoskeletal disorders (UEMDs) living in rural communities and examine whether upper extremity diseases affected upper extremity functional activity in each group (normal/low HGS) and whether grip strength (GS) was an effect modifier in upper extremity functional activity.

Methods: A total of 239 women older than 60 years who had completed a medical workup for epicondylitis, rotator cuff tears, and/or hand osteoarthritis were included in the final study. Functional activity was assessed by DASH, and muscle strength was measured by GS. Read More

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https://www.dovepress.com/determining-functional-activity-pr
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http://dx.doi.org/10.2147/CIA.S187066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241862PMC
January 2019
3 Reads

Prevalence and treatment of hip and knee osteoarthritis in people aged 60 years or older in Germany: an analysis based on health insurance claims data.

Clin Interv Aging 2018 14;13:2339-2349. Epub 2018 Nov 14.

Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany.

Objective: Osteoarthritis (OA) is highly prevalent throughout the world, especially in the elderly population, and is strongly associated with patients' frailty. However, little is known about the prevalence and treatment of OA in elderly patients in routine clinical care in Germany.

Materials And Methods: As a part of Linking Patient-Reported Outcomes with CLAIms Data for Health Services Research in Rheumatology (PROCLAIR), a cross-sectional study using claims data from a large Germany statutory health insurance (BARMER) was conducted. Read More

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https://www.dovepress.com/prevalence-and-treatment-of-hip-an
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http://dx.doi.org/10.2147/CIA.S174741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241868PMC
January 2019
15 Reads

The effectiveness of virtual reality training in reducing the risk of falls among elderly people.

Clin Interv Aging 2018 14;13:2329-2338. Epub 2018 Nov 14.

Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.

Background: Virtual reality (VR) training using modern game consoles is an innovative rehabilitation method for fall-prone elderly people. The aim of this study was to assess the effectiveness of VR training using the "Xbox 360 Kinect" in people over 60 years of age.

Materials And Methods: The study involved 23 people, including 19 women and 4 men (mean age 75. Read More

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http://dx.doi.org/10.2147/CIA.S183502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241865PMC
January 2019
2 Reads

Distribution and evaluation of sense of coherence among older immigrants before and after a health promotion intervention - results from the RCT study promoting aging migrants' capability.

Clin Interv Aging 2018 14;13:2317-2328. Epub 2018 Nov 14.

Institute of Neuroscience and Physiology, Section for Health and Rehabilitation, The Sahlgrenska Academy, University of Gothenburg, Sweden,

Background: The migration process can be a threat to a person's sense of coherence (SOC) and to their ability to experience life as comprehensible, manageable, and meaningful. Seen from a salutogenic perspective, this may have a negative impact on the experience of health.

Purpose: We describe the distribution of SOC and its components among older persons with an immigrant background now aging in Sweden. Read More

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http://dx.doi.org/10.2147/CIA.S177791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241858PMC
January 2019
1 Read

A posturographic procedure assessing balance disorders in Parkinson's disease: a systematic review.

Clin Interv Aging 2018 12;13:2301-2316. Epub 2018 Nov 12.

Department of Human Motor Behavior, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland,

Postural instability is common in Parkinson's disease (PD), often contributing to falls, injuries, and reduced mobility. In the clinical setting, balance disorder is commonly diagnosed using clinical tests and balance scales, but it is suggested that the most sensitive measurement is the force platform. The aim of this systematic review was to summarize the methods and various posturographic procedures used to assess the body balance and gait in PD. Read More

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http://dx.doi.org/10.2147/CIA.S180894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237244PMC
January 2019
2 Reads

Frailty and health care use among community-dwelling older adults with diabetes: a population-based study.

Clin Interv Aging 2018 8;13:2295-2300. Epub 2018 Nov 8.

Division of Preventive Medicine and Health Service Research, Institute of Population Health Sciences, National Health Research Institutes, Maoli 350, Taiwan,

Purpose: The aims of this study were to investigate the prevalence of frailty and its relationship with health care use among community-dwelling older adults with diabetes.

Methods: We analyzed data from a nationally representative sample of people aged 65 years and above (n=3,203) participating in the 2013 National Health Interview Survey in Taiwan. A total of 719 participants had a history of self-reported physician-diagnosed diabetes. Read More

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http://dx.doi.org/10.2147/CIA.S183681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233865PMC
January 2019
1 Read