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    1534 results match your criteria Clinical Interventions in Aging[Journal]

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    Prevalence of geriatric syndromes among people aged 65 years and older at four community clinics in Moscow.
    Clin Interv Aging 2018 9;13:251-259. Epub 2018 Feb 9.
    Department of Family Medicine, Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Background: Geriatric syndromes (GSs) are common in older adults and have a significant effect on their quality of life, disability, and use of health care resources. Few studies have assessed the prevalence of GSs in Russia. The aim of this study is to assess the prevalence of GSs among older adults living in the community in Moscow. Read More

    Vitrectomy in patients 85 years of age and older: surgical outcomes and visual prognosis.
    Clin Interv Aging 2018 9;13:243-249. Epub 2018 Feb 9.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Purpose: To evaluate visual and surgical outcomes in very elderly patients (above 85 years of age) undergoing pars plana vitrectomy (PPV).

    Patients And Methods: A single-center, retrospective study was carried out on the medical records of 82 patients aged 85 years and older who had undergone PPV from 2006 to 2013. Patients ranged in age from 86 to 99 years, with a mean age of 88. Read More

    An open-label, prospective interventional study of the tolerability and efficacy of 0.4 mg oral tamsulosin oral controlled absorption system in men with lower urinary tract symptoms associated with benign prostatic hyperplasia who are unsatisfied with treatment with 0.2 mg tamsulosin.
    Clin Interv Aging 2018 8;13:235-242. Epub 2018 Feb 8.
    Department of Urology.
    Purpose: The aim of this study was to investigate the efficacy and tolerability of switching from 0.2 mg tamsulosin to 0.4 mg tamsulosin oral controlled absorption system (OCAS) over a 12-week period in Taiwanese men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Read More

    Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease.
    Clin Interv Aging 2018 7;13:221-233. Epub 2018 Feb 7.
    Department of Bionano Technology, Gachon University, Seongnam, South Korea.
    Genetic variations play an important role in the clinical presentation and progression of Alzheimer's disease (AD), especially early-onset Alzheimer's disease. Hundreds of mutations have been reported with the majority resulting from alterations in β-amyloid precursor protein (), presenilin 1 (), or presenilin 2 () genes. The roles of these mutations in the pathogenesis of AD have been classically confirmed or refuted through functional studies, where the mutations are cloned, inserted into cell lines, and monitored for changes in various properties including cell survival, amyloid production, or Aβ42/40 ratio. Read More

    Immediate synergistic effect of a trunk orthosis with joints providing resistive force and an ankle-foot orthosis on hemiplegic gait.
    Clin Interv Aging 2018 5;13:211-220. Epub 2018 Feb 5.
    Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo.
    Purpose: The synergistic effects of a trunk orthosis and an ankle-foot orthosis (AFO) in stroke patients with a hemiplegic gait are unclear. We previously developed a trunk orthosis with joints providing resistive force (TORF) to modify malalignment of the trunk and pelvis and confirmed its positive effects in stroke patients during level walking without an AFO. The aim of the present study was to determine if this trunk orthosis and an AFO have synergistic effects during level walking in community-dwelling patients with chronic stroke. Read More

    Comparison of three tools for predicting primary osteoporosis in an elderly male population in Beijing: a cross-sectional study.
    Clin Interv Aging 2018 2;13:201-209. Epub 2018 Feb 2.
    Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University.
    Purpose: In this cross-sectional study, three clinical tools, the Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment Tool (FRAX) without bone mineral density (BMD), and body mass index (BMI), for predicting primary osteoporosis (OP) were compared and ideal thresholds for omission of screening BMD were proposed in a community-dwelling elderly Han Beijing male population.

    Patients And Methods: A total of 1,349 community-dwelling elderly Han Beijing males aged ≥50 years were enrolled in this study. All subjects completed a questionnaire and measured BMD by dual-energy X-ray absorptiometry (DXA). Read More

    Feasibility and safety of elective laparoscopic total extraperitoneal preperitoneal groin hernia repair in the elderly: a propensity score-matched comparison.
    Clin Interv Aging 2018 2;13:195-200. Epub 2018 Feb 2.
    Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.
    Background: Several studies of hernia registries have revealed that elderly patients have higher perioperative complication rates compared with younger patients. However, the incidence of hernia increases with the aging process. To evaluate the feasibility and safety of laparoscopic hernia repair in elderly patients (≥75 years), we conducted a prospective case-matched control study to compare perioperative outcomes between patients older and younger than 75 years. Read More

    Functionality and Outcome in Older Patients with Severe Aortic Stenosis (FOOPAS): an interdisciplinary study concept for a prospective trial.
    Clin Interv Aging 2018 1;13:185-193. Epub 2018 Feb 1.
    Department of Cardiology, Paracelsus Medical University, Nuremberg, Germany.
    Background: Frailty is a geriatric syndrome that can influence mortality and functional recovery after treatment of severe aortic stenosis (AS). The integration of standardized geriatric assessment (GA) in clinical practice is limited by a lack of consensus on how to measure it.

    Objectives: This study aims to compare the incremental predictive value of different frailty scales to predict the outcomes following surgical aortic valve replacement, transcatheter aortic valve implantation, and conservative treatment of severe AS. Read More

    Developing an assessment based on physical fitness age to evaluate motor function in frail and healthy elderly women.
    Clin Interv Aging 2018 26;13:179-184. Epub 2018 Jan 26.
    Nonprofit Organization Nagasaki Wellness Sports Research Center, Nagasaki, Japan.
    Objectives: The purpose of this study was to identify a method for assessing physical fitness age that is easy to use with both frail and healthy elderly women and to examine its validity.

    Methods: Principal component analysis was used to develop a formula of physical fitness age from four motor function variables. The subjects comprised 688 (75. Read More

    Implementing Dementia Care Mapping as a practice development tool in dementia care services: a systematic review.
    Clin Interv Aging 2018 26;13:165-177. Epub 2018 Jan 26.
    Centre for Dementia Research, School of Health and Community Studies, Leeds Beckett University, Leeds, UK.
    Dementia Care Mapping (DCM) is an observational tool set within a practice development process. Following training in the method, DCM is implemented via a cyclic process of briefing staff, conducting mapping observations, data analysis and report preparation, feedback to staff and action planning. Recent controlled studies of DCM's efficacy have found heterogeneous results, and variability in DCM implementation has been indicated as a potential contributing factor. Read More

    A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes.
    Clin Interv Aging 2018 26;13:159-163. Epub 2018 Jan 26.
    Department of Neurology and Research Center of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou.
    Background: The purpose of this study was to analyze the disease distribution of patients in the late stage of dementia through a cross-sectional investigation and to clarify the association between apolipoprotein E () genotypes and the serum levels of total cholesterol, total triglycerides, and blood glucose in the late-stage Alzheimer's disease (AD) patients.

    Methods: Patients who were in the late stage of dementia in a mental health center were enrolled in this study. A broad battery of neuropsychological tests and neuroimaging was applied to make the diagnosis. Read More

    Nutritional variables predict chances of returning home and activities of daily living in post-acute geriatric care.
    Clin Interv Aging 2018 26;13:151-157. Epub 2018 Jan 26.
    Department of Surgery, Tamana Regional Health Medical Center, Kumamoto, Japan.
    Background: Little is known about the association between malnutrition and the chances of returning home from post-acute facilities in older adult patients. This study aimed to understand whether malnutrition and malnutrition-related factors would be determinants for returning home and activities of daily living (ADL) at discharge after post-acute care.

    Methods: Patients aged ≥65 years living at home before the onset of an acute disease and admitted to a post-acute ward were enrolled (n=207) in this prospective observational study. Read More

    Quality of life and psychological consequences in elderly patients after a hip fracture: a review.
    Clin Interv Aging 2018 24;13:143-150. Epub 2018 Jan 24.
    Department of Orthopaedic Surgery and Musculoskeletal Trauma, Medical School, University of Thessaly, Larissa, Greece.
    Fractures due to fragility of the bone around the hip joint have become a major public health issue, presenting with an increasing incidence due to the growth of the elderly population. The purpose of this review was to evaluate the impact of hip fractures on the quality of life (QoL), health status (HS), functioning, and psychological parameters, and factors influencing the outcome and the appropriate interventions for improvement of elderly patients. A systematic electronic search of the relevant literature was carried out using the CINAHL, Cochrane, EMBASE, Medline (OvidSP), and PubMed databases spanning the time period from their establishment up to January 2017. Read More

    Perioperative outcome of elderly versus younger patients undergoing major hepatic or pancreatic surgery.
    Clin Interv Aging 2018 24;13:133-141. Epub 2018 Jan 24.
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    Objective: The aim of this study was to determine the safety of elderly cancer patients (≥70 years) undergoing hepatic resection (HR) or pancreaticoduodenectomy (PD) in comparison with younger adults (<70 years).

    Methods: A total of 1,012 consecutive patients undergoing HR or PD were included. The incidence and severity of morbidity were documented within 30 days postoperatively and compared between elderly and younger groups. Read More

    High-speed jaw-opening exercise in training suprahyoid fast-twitch muscle fibers.
    Clin Interv Aging 2018 22;13:125-131. Epub 2018 Jan 22.
    Gerodontology and Oral Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo.
    Purpose: This study was aimed to examine the effectiveness of a high-speed jaw-opening exercise, which targets the contraction of fast-twitch muscle fibers, in improving swallowing function.

    Subjects And Methods: Twenty-one subjects (mean age 74.0±5. Read More

    Different doses of steroid injection in elderly patients with carpal tunnel syndrome: a triple-blind, randomized, controlled trial.
    Clin Interv Aging 2018 18;13:117-124. Epub 2018 Jan 18.
    Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
    Background: Carpal tunnel syndrome (CTS) is commonly seen in elderly populations, in part due to increased presence of predisposing comorbidities as well as physiological changes. We aimed at comparing the effectiveness of different doses of steroid using the ultrasound-guided hydrodissection method in elderly patients with CTS.

    Methods: We conducted a prospective, triple-blind, randomized, controlled trial in elderly patients with CTS. Read More

    Influence of cigarette smoking on hormone and lipid metabolism in women in late reproductive stage.
    Clin Interv Aging 2018 17;13:109-115. Epub 2018 Jan 17.
    Department of Nursing.
    Background: The aim of the study was to analyze lipid and hormone metabolism, body mass index (BMI), and age parameters in late reproductive stage women in relation to cigarette smoking.

    Methods: The study enrolled 345 healthy late reproductive stage women living in Poland; 13.33% were smokers. Read More

    Integrating participatory ergonomic management in non-weight-bearing exercise and progressive resistance exercise on self-care and functional ability in aged farmers with knee osteoarthritis: a clustered randomized controlled trial.
    Clin Interv Aging 2018 17;13:101-108. Epub 2018 Jan 17.
    Department of Orthopaedic Surgery and Physical Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
    Background: Ergonomic hazards are the most important cause of knee osteoarthritis (OA) in aged para rubber farmers. Ergonomic management comprising improvement of working conditions and muscle-strengthening exercise has been well documented in terms of workers' health benefit. However, those interventions were not adequate to sustain the advantage. Read More

    Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area.
    Clin Interv Aging 2018 12;13:91-99. Epub 2018 Jan 12.
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
    Purpose: It is important to define lean muscle mass when diagnosing sarcopenia, but there is still controversy on the clinical implication of sarcopenia derived by height, weight, and body mass index (BMI) adjusted muscle mass indices. We aimed to evaluate the longitudinal clinical relevance of 3 sarcopenia definitions in the Korean population.

    Patients And Methods: We conducted comprehensive geriatric assessments for 1,379 community-dwelling older participants in the Aging Study of PyeongChang Rural Area (ASPRA) cohort and followed them up prospectively for death, institutionalization, and disability every 3 months. Read More

    Sex-related differences in effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly patients.
    Clin Interv Aging 2018 5;13:81-89. Epub 2018 Jan 5.
    Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
    Purpose: Cough on anesthetic emergence should be prevented considering its dangerous complications. Target-controlled infusion (TCI) of remifentanil can reduce emergence cough effectively, and sex-related differences in effect-site concentration (Ce) of remifentanil have been evaluated in young patients. In this study, we determined the Ce of remifentanil for preventing emergence cough following extubation in male and female elderly patients and evaluated the sex-related difference. Read More

    The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis.
    Clin Interv Aging 2018 4;13:73-79. Epub 2018 Jan 4.
    Anesthesia Department, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: Osteoarthritis (OA) is a chronic joint disease that usually occurs in older people and leads to pain and disabilities. OA treatment ranges from drug therapy to surgery. Drug and rehabilitation therapy are preferred over surgery, and, especially, there is a tendency toward compounds causing regenerative changes in the knee joint. Read More

    Sources and directions of social support and life satisfaction among solitary Chinese older adults in Hong Kong: the mediating role of sense of loneliness.
    Clin Interv Aging 2018 4;13:63-71. Epub 2018 Jan 4.
    Personal Social Services Research Unit, London School of Economics and Political Science, London, UK.
    Based on survey data collected from 151 community-dwelling solitary Chinese older adults in Hong Kong, the present study used path analysis to examine the mediating role of sense of loneliness in the relationship between different sources and directions of social support and life satisfaction. The results showed that sense of loneliness mediated the effects of support from families, friends, and support for others on life satisfaction. In addition, a formal source of social support was not associated with life satisfaction among solitary older adults, although those with a more secure financial status had greater overall life satisfaction. Read More

    Clinical observations on the use of new anti-VEGF drug, conbercept, in age-related macular degeneration therapy: a meta-analysis.
    Clin Interv Aging 2018 27;13:51-62. Epub 2017 Dec 27.
    Department of Ophthalmology, Beijing Chao-Yang Hospital, Beijing, China.
    Purpose: Conbercept is a new anti-vascular endothelial growth factor (VEGF) drug approved for the treatment of age-related macular degeneration (AMD). Although this novel drug has been widely used in clinic, unlike other anti-VEGF drugs, validation and consensus on its method of clinical application and clinical safety have not yet been achieved.

    Methods: Relevant literature was searched on PubMed, Web of Science, China National Knowledge Internet, and Wanfang Data. Read More

    Best strategies to recruit and enroll elderly Blacks into clinical and biomedical research.
    Clin Interv Aging 2018 22;13:43-50. Epub 2017 Dec 22.
    Department of Internal Medicine, Howard University Teaching Hospital, Washington, DC, USA.
    Background: Historically, Blacks have been disproportionately underrepresented in clinical trials. Outcomes associated with low Blacks' participation in research include poor understanding of the predictors and treatment of the disease, increasing health disparities, poor health equity, and suboptimal wellness of the nation as a whole. To address this gap in research participation, we analyzed our recruitment data to identify the most effective strategies for enrolling older Blacks in clinical trials. Read More

    Clinical utility of the revised cardiac risk index in older Chinese patients with known coronary artery disease.
    Clin Interv Aging 2018 22;13:35-41. Epub 2017 Dec 22.
    Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
    Objectives: The revised Cardiac Risk Index (RCRI) is the most widely used risk prediction tool for postoperative cardiac adverse events. We aim to explore the predictive ability of the RCRI in older Chinese patients with coronary artery disease (CAD) undergoing noncardiac surgery, which has not been previously evaluated.

    Methods: We performed a multicenter, prospective study. Read More

    Pain Assessment in Impaired Cognition (PAIC): content validity of the Dutch version of a new and universal tool to measure pain in dementia.
    Clin Interv Aging 2018 22;13:25-34. Epub 2017 Dec 22.
    Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden.
    Objectives: Detection and measurement of pain in persons with dementia by using observational pain measurement tools is essential. However, the evidence for the psychometric properties of existing observational tools remains limited. Therefore, a new meta-tool has been developed: Pain Assessment in Impaired Cognition (PAIC), as a collaborative EU action. Read More

    Profile of sugammadex for reversal of neuromuscular blockade in the elderly: current perspectives.
    Clin Interv Aging 2018 22;13:13-24. Epub 2017 Dec 22.
    Department of Medicine, Anesthesiology, and Intensive Care, University of Padova, Padua, Italy.
    The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of perioperative morbidity and mortality. Read More

    Compression of the right coronary artery by an aortic pseudoaneurysm after infective endocarditis: an unusual case of myocardial ischemia.
    Clin Interv Aging 2018 21;13:9-11. Epub 2017 Dec 21.
    Cardiology Department, Hospital Universitario de Canarias, Tenerife.
    A 61-year-old male with a prosthetic St Jude aortic valve size 24 presented with heart failure symptoms and minimal-effort angina. Eleven months earlier, the patient had undergone cardiac surgery because of an aortic root dilatation and bicuspid aortic valve with severe regurgitation secondary to infectious endocarditis byand coronary artery disease in the left circumflex coronary artery. Then, a prosthesis valve and a saphenous bypass graft to the left circumflex coronary artery were placed. Read More

    Hip muscle and hand-grip strength to differentiate between older fallers and non-fallers: a cross-sectional validity study.
    Clin Interv Aging 2018 21;13:1-8. Epub 2017 Dec 21.
    Department of Physiotherapy, HES-SO University of Applied Sciences and Arts of Western Switzerland, Geneva, Switzerland.
    Background: Hip muscle weakness in older people seems to be an influencing factor of falls. Currently, it is unclear which muscles out of the hip muscle group play an important role in older people. A validating process in the measurement regarding muscle strength related to falls is necessary before answering that question. Read More

    A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults.
    Clin Interv Aging 2017 14;12:2123-2130. Epub 2017 Dec 14.
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Introduction: Previously, we discussed several critical barriers in including [F] fluorodeoxyglucose positron emission tomography ([F]FDG-PET) imaging of preclinical Alzheimer's disease (AD) subjects. These factors included the reference region selection and intensity normalization of PET images and the within- and across-subject variability of affected brain regions. In this study, we utilized a novel FDG-PET analysis, the regional FDG time correlation coefficient, rFTC, that can address and resolve these barriers and provide a more sensitive way of monitoring longitudinal changes in metabolism of cognitively normal elderly adults. Read More

    A multicenter controlled study for dementia prevention through physical, cognitive and social activities - GESTALT-kompakt.
    Clin Interv Aging 2017 14;12:2109-2121. Epub 2017 Dec 14.
    Department of Sport Science and Sport, Faculty of Humanities, Social Sciences, and Theology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
    Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). Read More

    Average annual cost of Parkinson's disease in São Paulo, Brazil, with a focus on disease-related motor symptoms.
    Clin Interv Aging 2017 14;12:2095-2108. Epub 2017 Dec 14.
    Hospital Israelita Albert Einstein, São Paulo.
    Background: Although Parkinson's disease is the second most prevalent neurodegenerative disease worldwide, its cost in Brazil - South America's largest country - is unknown.

    Objective: The goal of this study was to calculate the average annual cost of Parkinson's disease in the city of São Paulo (Brazil), with a focus on disease-related motor symptoms.

    Subjects And Methods: This was a retrospective, cross-sectional analysis using a bottom-up approach (ie, from the society's perspective). Read More

    Impact of the number of aspiration risk factors on mortality and recurrence in community-onset pneumonia.
    Clin Interv Aging 2017 7;12:2087-2094. Epub 2017 Dec 7.
    Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Introduction: The clinical significance of the number of aspiration risk factors in patients with pneumonia is unknown as yet. In the present study, we clarify the significance of the number of aspiration risk factors for mortality and recurrence in pneumonia patients.

    Methods: This study included 322 patients hospitalized with pneumonia between December 2014 and June 2016. Read More

    Application of Haralick texture features in brain [F]-florbetapir positron emission tomography without reference region normalization.
    Clin Interv Aging 2017 7;12:2077-2086. Epub 2017 Dec 7.
    Department of Radiology and Radiological Sciences.
    Objectives: Semi-quantitative image analysis methods in Alzheimer's Disease (AD) require normalization of positron emission tomography (PET) images. However, recent studies have found variabilities associated with reference region selection of amyloid PET images. Haralick features (HFs) generated from the Gray Level Co-occurrence Matrix (GLCM) quantify spatial characteristics of amyloid PET radiotracer uptake without the need for intensity normalization. Read More

    Role of adipose tissue in facial aging.
    Clin Interv Aging 2017 6;12:2069-2076. Epub 2017 Dec 6.
    Wellcomet GmbH, Karlsruhe, Germany.
    Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging. Read More

    Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease.
    Clin Interv Aging 2017 5;12:2063-2068. Epub 2017 Dec 5.
    Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara.
    Background: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, inflammatory markers and subclinical atherosclerosis in elderly diabetics without overt CVD. Read More

    The link between weight shift asymmetry and gait disturbances in chronic hemiparetic stroke patients.
    Clin Interv Aging 2017 1;12:2055-2062. Epub 2017 Dec 1.
    Department of Neurology, Professor Leszek Giec, Upper Silesian Medical Centre, Medical University of Silesia, Katowice, Poland.
    Introduction: While the asymmetry of body posture and the asymmetrical nature of hemiparetic gait in poststroke (PS) patients are well documented, the role of weight shift asymmetry in gait disorders after stroke remains unclear.

    Objective: We examined the association of weight-bearing asymmetry (WBA) between paretic and nonparetic lower limbs during quiet standing with the degree of deviation of hemiplegic gait from normal gait evaluated by the Gillette Gait Index (GGI) incorporating 16 distinct clinically important kinematic and temporal parameters in chronic PS patients.

    Participants And Methods: Twenty-two ambulatory patients with chronic stroke aged between 50 and 75 years were included in this study. Read More

    Efficacy comparison of intramedullary nails, locking plates and conservative treatment for displaced proximal humeral fractures in the elderly.
    Clin Interv Aging 2017 29;12:2047-2054. Epub 2017 Nov 29.
    Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
    Purpose: The incidence of proximal humeral fractures is high in the elderly, and the superior management of these fractures remains a controversy. The study aims to compare clinical outcomes of intramedullary nails, locking plates and conservative treatment for the management of displaced proximal humeral fractures in the elderly.

    Patients And Methods: In this prospective study, a total of 198 patients with 2- or 3-part proximal humeral fractures who received fixation of locking plates or intramedullary nails or conservative treatment were included. Read More

    Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus.
    Clin Interv Aging 2017 29;12:2039-2045. Epub 2017 Nov 29.
    Intensive Medicine, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi, China.
    Objective: The primary objective of this study was to evaluate whether the polymorphism of poly (ADP-ribose) polymerase-1 (PARP-1) is involved as a potential risk factor in the development of acute renal injury in elderly Chinese patients with diabetes mellitus.

    Subjects And Methods: In this pilot study, diabetic patients of either gender (aged ≥65 years) with a confirmed diagnosis of acute renal injury and individuals with no clinical symptoms of acute renal injury were enrolled at Nanxishan Hospital of Guangxi Zhuang Autonomous Region, China. Genetic polymorphism of PARP-1 was assessed using polymerase chain reaction-restriction fragment length polymorphism assay. Read More

    Clinical application of arthroscopy-assisted minimally invasive therapy in Chinese elderly with type III Pilon fracture.
    Clin Interv Aging 2017 28;12:2033-2038. Epub 2017 Nov 28.
    The Eleventh Department of Orthopaedics, The Fifth Hospital of Harbin, Harbin, China.
    Objective: Pilon fracture is so complex that its therapy poses a great challenge to surgeons. Few studies have compared arthroscopy-assisted minimally invasive therapy and external fixation combined with limited internal fixation (EFLIF), and an optimal choice of surgical therapy remains unclear in patients with type III Pilon fracture. Moreover, to our knowledge, very few studies have specifically evaluated arthroscopy-assisted minimally invasive therapy in Chinese elderly with type III Pilon fracture. Read More

    The mediating role of psychological symptoms on falls risk among older adults with osteoarthritis.
    Clin Interv Aging 2017 28;12:2025-2032. Epub 2017 Nov 28.
    Ageing and Age-Associated Disorders Research Group, University of Malaya, Kuala Lumpur, Malaysia.
    The purpose of this study was to investigate the role of fear of falling (FoF) and psychological symptoms in explaining the relationship between osteoarthritis (OA) symptom severity and falls. Individuals aged ≥65 years with ≥2 falls or ≥1 injurious fall over the past 12 months were included in the falls group, while volunteers aged ≥65 years with no history of falls over 12 months were recruited as controls. The presence of lower extremity OA was determined radiologically and clinically. Read More

    Emotion experience and frailty in a sample of Italian community-dwelling older adults.
    Clin Interv Aging 2017 28;12:2017-2024. Epub 2017 Nov 28.
    Department of Psychology, University of Turin, Turin, Italy.
    Frailty increases individual vulnerability to external stressors and involves high risk for adverse geriatric outcomes. To date, few studies have addressed the role of emotion perception and its association with frailty in aged populations. This cross-sectional study aimed to explore whether a significant association between frailty and emotional experience exists in a sample of Italian community-dwelling older adults. Read More

    Timed Up and Go Test can predict recurrent falls: a longitudinal study of the community-dwelling elderly in China.
    Clin Interv Aging 2017 28;12:2009-2016. Epub 2017 Nov 28.
    Department of Rehabilitation Medicine, Tianjin Economic-Technological Development Area International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University.
    Purpose: Falling is a major health problem in community-dwelling elderly individuals. The aim of the present study was to conduct a prospective investigation to evaluate the accuracy of the Timed Up and Go Test (TUGT), 4-meter walking test, and grip strength test to screen for the risk of falls and to determine a cutoff point to be used clinically.

    Patients And Methods: This was a prospective study that included 541 participants. Read More

    The increase in health care costs associated with muscle weakness in older people without long-term illnesses in the Czech Republic: results from the Survey of Health, Ageing and Retirement in Europe (SHARE).
    Clin Interv Aging 2017 27;12:2003-2007. Epub 2017 Nov 27.
    Centre of Expertise in Longevity and Long-term Care, Faculty of Humanities, Charles University, Prague, Czech Republic.
    Muscle weakness and associated diseases are likely to place a considerable economic burden on government health care expenditure. Therefore, our aim for this study was to estimate the direct and indirect costs associated with muscle weakness in the Czech Republic. We applied a cost-of-illness approach using data from the Survey of Health, Ageing and Retirement in Europe (SHARE). Read More

    Prediction of risk of depressive symptoms in menopausal women based on hot flash and sweating symptoms: a multicentre study.
    Clin Interv Aging 2017 23;12:1993-2001. Epub 2017 Nov 23.
    Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital.
    Objective: The present study aimed to develop a symptom-based (namely, hot flashes and sweating) scoring system for predicting the risk of depressive symptoms in menopausal women via a multicentre cross-sectional survey.

    Methods: The data examined in the present study were obtained from 1,004 women aged 40-60 years who underwent physical examination at A Hospital. The basic information was obtained using a questionnaire-based survey. Read More

    Mortality after major amputation in elderly patients with critical limb ischemia.
    Clin Interv Aging 2017 22;12:1985-1992. Epub 2017 Nov 22.
    Department of Surgery, Amphia Hospital, Breda.
    Background: Owing to the aging population, the number of elderly patients with critical limb ischemia (CLI) has increased. The consequence of amputation is immense. However, at the moment, information about the mortality after amputation in the elderly vascular patients is unknown. Read More

    The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case-control study.
    Clin Interv Aging 2017 21;12:1977-1984. Epub 2017 Nov 21.
    Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
    Background: The association between interstitial lung disease (ILD) and selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors (SSRI/SNRI) has been previously described in published case reports. However, its prevalence may be more common than expected. We examined the association between SSRI/SNRI usage and presence of ILD and or bronchiectasis (ILD/B) in an elderly population. Read More

    Computerized cognitive stimulation and engagement programs in older adults with mild cognitive impairment: comparing feasibility, acceptability, and cognitive and psychosocial effects.
    Clin Interv Aging 2017 21;12:1967-1975. Epub 2017 Nov 21.
    Department of Clinical Gerontology, Broca Hospital, Public Assistance - Paris Hospitals (AP-HP).
    Purpose: Mild cognitive impairment (MCI) is associated with a higher risk of dementia and is becoming a topic of interest for pharmacological and nonpharmacological interventions. With advances in technology, computer-based cognitive exercises are increasingly integrated into traditional cognitive interventions, such as cognitive training. Another type of cognitive intervention involving technology use is cognitive engagement, consisting of involving participants in highly motivational and mentally challenging activities, such as learning to use a form of new digital technology. Read More

    Do older drivers with bilateral cataract self-regulate their driving while waiting for first eye cataract surgery?
    Clin Interv Aging 2017 8;12:1911-1920. Epub 2017 Nov 8.
    Eye & Vision Epidemiology Research (EVER) Group, Perth, Australia.
    Objectives: To analyze the association between visual impairment and driver self-regulation among a cohort of older drivers waiting for first eye cataract surgery.

    Methods: Ninety-six drivers with bilateral cataract aged 55+ years were assessed before first eye cataract surgery. Data collection consisted of a researcher-administered questionnaire, objective visual measures (visual acuity, contrast sensitivity and stereopsis), a visual attention test (the useful field of view test) and a cognitive test (the Mini-Mental State Examination). Read More

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