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    4552 results match your criteria Clinical Immunology[Journal]

    1 OF 92

    The regulatory roles of B cell subsets in transplantation.
    Expert Rev Clin Immunol 2018 Jan 17. Epub 2018 Jan 17.
    a State Key Laboratory of Membrane Biology, Institute of Zoology , Chinese Academy of Sciences , Beijing , China.
    Introduction: B cells mediate allograft rejection through antigen presentation, and production of cytokines and antibodies. More and more immunosuppressive agents specifically targeting B cells and plasma cells have been applied in clinical transplantation. However, recent studies have indicated the regulatory roles of B cells. Read More

    From clinical remission to residual disease activity in spondyloarthritis and its potential treatment implications.
    Expert Rev Clin Immunol 2018 Jan 17. Epub 2018 Jan 17.
    a Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio" , Università degli Studi del Molise , Campobasso , Italy.
    Introduction: Remission or low disease activity should be the target of therapy in spondyloarthritis (SpA). Due to the complexity of the disease, several composite indices that assess all disease domains were proposed to define a status of low disease activity/remission in both axial and peripheral SpA. With the introduction, in the past years, of effective biologic and targeted synthetic treatments aimed at inhibiting key cytokines and intracellular pathways, the goal of clinical remission has become an achievable target in these conditions. Read More

    Belimumab and antipneumococcal vaccination in patients with systemic lupus erythematosus.
    Expert Rev Clin Immunol 2018 Jan 16. Epub 2018 Jan 16.
    c University of Medicine and Pharmacy Grigore T Popa , Department Medicine III-Bioethics , 16 Universitatii Str., Romania , Iasi 700115.
    In systemic lupus erythematosus (SLE), flares can be caused by infections. In particular, Streptococcus pneumoniae infection can be severe or even potentially lethal in absence of previous immunization or in case of "aggressive" systemic antibiotic therapy. Immunization efficacy, however, can be reduced in such patients with the use of the various immunosuppressive therapeutic regimens. Read More

    Pediatric-onset Evans syndrome: Heterogeneous presentation and high frequency of monogenic disorders including LRBA and CTLA4 mutations.
    Clin Immunol 2018 Jan 9. Epub 2018 Jan 9.
    INSERM UMR 1163, Laboratory of Immunogenetics of pediatric autoimmune diseases, Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France; Pediatric immuno-hematology and rhumatology unit, RAISE reference centre for pediatric inflammatory rheumatic diseases and systemic autoimmune diseases, Necker-Enfants Malades University Hospital, Assistance publique - Hôpitaux de Paris, France.
    Evans syndrome (ES) is defined by the combination of autoimmune hemolytic anemia and immune thrombocytopenia. Clinical presentation includes manifestations of immune dysregulation, found in primary immune deficiencies, autoimmune lymphoproliferative syndrome with FAS (ALPS-FAS), Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) and Lipopolysaccharide-Responsive vesicle trafficking Beige-like and Anchor protein (LRBA) defects. We report the clinical history and genetic results of 18 children with ES after excluding ALPS-FAS. Read More

    Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype.
    Clin Immunol 2018 Jan 9. Epub 2018 Jan 9.
    San Diego Biomedical Research Institute, San Diego, CA, USA. Electronic address:
    CD4+ T cells that co-express CD25 and CD127 (CD25+CD127+) make up around 20% of all circulating CD4+ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25+CD127hi cells. Read More

    Adherence to biologics in patients with psoriasis.
    Expert Rev Clin Immunol 2018 Jan 16:1-7. Epub 2018 Jan 16.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: Psoriasis has a profound impact on patients' lives, but adherence to topical treatment of psoriasis is still poor. Biologic treatment has revolutionized the management of psoriasis, but adherence to treatment may still be a barrier for some patients. Areas covered: A PubMed search was conducted in August 2017 using the terms 'biologics psoriasis adherence' and 'biologics psoriasis survival. Read More

    Disease staging and sub setting of interstitial lung disease associated with systemic sclerosis: impact on therapy.
    Expert Rev Clin Immunol 2018 Jan 10. Epub 2018 Jan 10.
    a Interstitial Lung Disease Unit , Royal Brompton Hospital , London SW3 6NP, UK.
    Introduction: Interstitial lung disease (ILD) is the most serious complication of systemic sclerosis (SSc). There is no accepted guidance as to which clinical, radiological or physiological thresholds should prompt initiation or changes in treatment. Furthermore, some patients with extensive disease remain stable without the need for intervention whilst others with limited disease at the outset, experience a precipitous decline. Read More

    Interferon β-1a and β-1b for patients with multiple sclerosis: updates to current knowledge.
    Expert Rev Clin Immunol 2018 Jan 10. Epub 2018 Jan 10.
    d Department of Neurology , Medical University of Vienna , Spitalgasse 23, 1090 Vienna , Austria.
    Introduction: Although multiple sclerosis (MS) remains incurable, interferon beta (IFNβ) has been at the forefront of treatment for many years. Different formulations of IFNβ allow for different levels of exposure: low-dose/frequency with some agents, and high-dose/frequency with others. Areas covered: This review article discusses existing and emerging efficacy and safety data for IFNβ in MS. Read More

    A young girl with severe cerebral fungal infection due to card 9 deficiency.
    Clin Immunol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Pediatric Immunology, Hacettepe University Children's Hospital, Ankara, Turkey.
    Pattern recognition receptors (PRRs), receptors of the innate immune system, are important in interaction with pathogens. Caspase Recruitment Domain-containing protein 9 (CARD9), a member of PRRs, is an intracellular adaptor protein important in fungal defense. CARD9 deficiency causes a rare primary immunodeficiency (PID) characterized by superficial and deep fungal infections. Read More

    Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.
    Clin Immunol 2018 Jan 3. Epub 2018 Jan 3.
    Seccion de Infectología e Inmunopatología, Unidad de Pediatria, Hospital Virgen del Rocío, Sevilla, Instituto de Biomedicina de Sevilla (IBiS), Spain.
    The CTLA-4 checkpoint regulates the activation of T cells. Individuals with heterozygous mutations in CTLA-4 have a complex phenotype typically characterized by antibody deficiency alongside variable autoimmunity. Despite severe disease in some individuals, others remain largely unaffected with reasons for this variation unknown. Read More

    Imatinib for the treatment of hypereosinophilic syndromes.
    Expert Rev Clin Immunol 2018 Jan 9:1-8. Epub 2018 Jan 9.
    a School of Medicine in Katowice, Medical University of Silesia , Department of Hematology and Bone Marrow Transplantation , Katowice , Poland.
    Introduction: Hypereosinophilic syndromes (HES) encompass a group of disorders defined by sustained peripheral blood hypereosinophilia >1500/mm3 and evidence of eosinophilia-associated organ impairment. Approximately 10% of HES patients may harbor a cryptic deletion on chromosome 4 leading to formation of the FIP1L1-PDGFRA (F/P) fusion gene; these patients are diagnosed as F/P-mutated myeloid/lymphoid neoplasms with eosinophilia (MLN-eo). Areas covered: This review discusses the results of IM treatment in HES depending on mutation status. Read More

    Hematopoietic cell transplantation in primary immunodeficiency - conventional and emerging indications.
    Expert Rev Clin Immunol 2018 Jan 16:1-12. Epub 2018 Jan 16.
    a Institute of Cellular Medicine , Newcastle University , Newcastle Upon Tyne , UK.
    Introduction: Hematopoietic stem cell transplantation (HSCT) is an established curative treatment for many primary immunodeficiencies. Advances in donor selection, graft manipulation, conditioning and treatment of complications, mean that survival for many conditions is now around 90%. Next generation sequencing is identifying new immunodeficiencies, many of which are treatable with HSCT. Read More

    The tropics, helminth infections and hygiene hypotheses.
    Expert Rev Clin Immunol 2018 Jan 10:1-4. Epub 2018 Jan 10.
    a Institute for Immunological Research , University of Cartagena , Cartagena , Colombia.
    The Tropics is very appropriate to test the hypotheses raised to explain the increasing trends of allergy and other inflammatory diseases worldwide. The absence of parasite infection as a possible cause of the increase of allergic diseases was proposed by J. Gerrard a long time ago; however, the idea that helminth infections, which induce a strong Th2 could reduce allergy symptoms seems counterintuitive; but the fact is that they have a dual effect: they increase the Th2 responses but also exert immunosuppression and both effects influence the symptoms of allergy. Read More

    Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome.
    Clin Immunol 2017 Dec 29. Epub 2017 Dec 29.
    Department of Rheumatism and Immunology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, Fujian 361003, China. Electronic address:
    In order to evaluate autoantibody to SP-1 as an early biomarker in pSS, we investigated autoantibody to SP-1 in Chinese patients with primary Sjögren's syndrome (pSS). Autoantibodies to SP-1 are significantly increased in pSS patients compared to RA patients, SLE patients, and healthy people without secondary SS. The presence of anti SP-1 antibodies was negatively correlated with the focus score (FS), RF, and salivary gland function. Read More

    Reduced frequency of peripheral CD4+CD45RA+CD31+ cells and autoimmunity phenomena in patients affected by Del22q11 syndrome.
    Clin Immunol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Immunology, Section of Pediatrics, Department of Health Sciences, University of Florence and Anna Meyer Children's Hospital, Florence, Italy.

    A novel bivalent fusion vaccine induces broad immunoprotection against Staphylococcus aureus infection in different murine models.
    Clin Immunol 2017 Dec 28. Epub 2017 Dec 28.
    National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China. Electronic address:
    With more and more drug-resistant Staphylococcus aureus strains emerging in hospitals, there is an urgent need to develop an effective vaccine to combat S. aureus infection. In this study, we constructed a novel bivalent fusion vaccine, SpA-DKKAA-FnBPA37-507 (SF), based on the D domain of staphylococcal protein A (SpA) and the A domain of fibronectin-binding protein A (FnBPA). Read More

    Effect of glucocorticoid treatment on BAFF and APRIL expression in patients with immune thrombocytopenia (ITP).
    Clin Immunol 2017 Dec 26. Epub 2017 Dec 26.
    Charité University Medicine Berlin, Institute of Transfusion Medicine, Augustenburger Platz 1, 13353 Berlin, Germany.
    Immune thrombocytopenic purpura (ITP) is an idiopathic bleeding disorder. B cell activating factor (BAFF) and 'A proliferation-inducing ligand' (APRIL) have regulatory effects on B and T cells and may represent relevant factors in the pathogenesis of ITP. Serum levels and gene expression were investigated in ITP patients. Read More

    Extracellular ATP signaling and clinical relevance.
    Clin Immunol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Since purinergic signaling was discovered in the early 1970s, it has been shown that extracellular nucleotides, and their derivative nucleosides, are released in a regulated or unregulated manner by cells in various challenging settings and then bind defined purinergic receptors to activate intricate signaling networks. Extracellular ATP plays a role based on different P2 receptor subtypes expressed on specific cell types. Sequential hydrolysis of extracellular ATP catalyzed by ectonucleotidases (e. Read More

    Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade.
    Clin Immunol 2017 Dec 20. Epub 2017 Dec 20.
    School of Biomedical Science, University of Western Australia, Nedlands, WA, Australia; Stem Cell Unit, Institute for Respiratory Health, Nedlands, WA, Australia; Department of Respiratory and Sleep Medicine, Fiona Stanley Hospital, Perth, WA, Australia.

    IL-21 dependent Granzyme B production of B-cells is decreased in patients with lupus nephritis.
    Clin Immunol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address:
    Objectives: B-cells play a crucial role in the pathogenesis of lupus nephritis. Recently, a separate subset has been discovered characterized by expression of Granzyme B. The aim of this study is to investigate this subset in patients with systemic lupus erythematosus (SLE). Read More

    Modulation the expression of natural killer cell activating receptor (NKp44) in the peripheral blood of diffuse large B-cell lymphoma patients and the correlation with clinic pathological features.
    Clin Immunol 2017 Dec 13. Epub 2017 Dec 13.
    Clinical Pathology Department, Faculty of Medicine, Menoufia University, Egypt.
    NK cell activation is one strategy to improve the immunotherapy of non-Hodgkin's lymphoma. So, we aimed to investigate expression of Natural killer cell activating receptor NKp44 in patients with diffuse large B-cell lymphoma (DLBCL) and its correlation with clinic pathological data. In this study, 30 new cases with DLBCL in addition to 20 healthy control were involved. Read More

    Altered natural killer cell cytokine profile in type 2 autoimmune hepatitis.
    Clin Immunol 2017 Dec 9. Epub 2017 Dec 9.
    Divisions of Infectious Diseases and Immunology and Pediatrics, Department of Medical Sciences and Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:
    Type 2 autoimmune hepatitis (AIH-2) is a rare disease presenting in early childhood. The immunopathogenetic mechanisms are poorly characterized, although a defect of regulatory T cells (Treg) has been shown. There is virtually no information on innate immune responses and natural killer (NK) cells in particular. Read More

    GM-CSF producing autoreactive CD4+ T cells in type 1 diabetes.
    Clin Immunol 2017 Dec 8. Epub 2017 Dec 8.
    CRTD-DFG Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden 01307, Germany; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany. Electronic address:
    The phenotype of autoreactive T cells in type 1 diabetes is described as Th1, Th17 and/or Th21, but is largely uncharacterized. We combined multi-parameter cytokine profiling and proliferation, and identified GM-CSF producing cells as a component of the response to beta cell autoantigens proinsulin and GAD65. Overall cytokine profiles of CD4+ T cell were not altered in type 1 diabetes. Read More

    STAT3-mediated epigenetic silencing of FOXP3 in LADA T cells is regulated through HDAC5 and DNMT1.
    Clin Immunol 2017 Dec 6. Epub 2017 Dec 6.
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital and the Diabetes Center, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China. Electronic address:
    In LADA patients, Tregs are reduced and FOXP3 is downregulated in CD4+ T cells, but the etiology remains unclear. Our study included in 20 LADA patients and 20 healthy control patients. qRT-PCR results showed that STAT3, HDAC3, HDAC5, SIRT1, DNMT1 and DNMT3b mRNAs were significantly upregulated in LADA CD4+ T cells than controls, while FOXP3 mRNA significantly decreased. Read More

    Chronic Granulomatous Disease in children: a single center experience.
    Clin Immunol 2017 Dec 7. Epub 2017 Dec 7.
    Stem Cell Laboratory, Section of Hematology and Blood Coagulation, Clinical Chemistry Laboratory, Diagnostics Department, ASST Spedali Civili of Brescia, Brescia, Italy. Electronic address:
    Chronic Granulomatous Disease (CGD) is caused by the failure of the phagocytes to kill pathogens. We carried out a retrospective analysis of cellular, molecular and clinical features of 14 young patients (mean age at the onset of symptoms and diagnosis: 10 and 25months, respectively), 7 with autosomal recessive and 7 X-linked form, referred to the Children's Hospital of Brescia between 1999 and 2016. Two new mutations were found, one localized in the CYBB and one in the NCF1 genes. Read More

    Diagnosing and managing patients with drug hypersensitivity.
    Expert Rev Clin Immunol 2018 Jan 4;14(1):29-41. Epub 2017 Dec 4.
    b Allergy Service , Carlos Haya Hospital (Pavilion C) , Malaga , Spain.
    Introduction: Diagnosing and managing drug hypersensitivity is challenging because there are no clear limits between different types of drug reactions. Distinguishing between type A (predictable) and type B (hypersensitivity) reactions when a drug is introduced on the market is not easy. When many people use a drug, adverse reactions can occur, conditioned by diverse genetic profiles, viral infections or concomitant therapy. Read More

    Venom immunotherapy in patients with allergic reactions to insect stings.
    Expert Rev Clin Immunol 2018 Jan 8;14(1):53-59. Epub 2017 Dec 8.
    c Allergy Unit , Sant'Anna Hospital, ASST Lariana , Como , Italy.
    Introduction: Allergy to Hymenoptera (Apis mellifera, Vespula species, Polistes species, Vespa crabro) venom can be safely and effectively treated by venom immunotherapy (VIT), which in the 40 years since its introduction has been able to prevent reactions to stings, and to treatment as well, though systemic reactions, occasionally severe, are possible. Areas covered: We reviewed the recent literature on VIT by searching in PubMed for the terms 'venom immunotherapy' and 'Hymenoptera venom immunotherapy' to highlight the current status of VIT and the likely development in the coming years. Expert commentary: VIT, provided the correct choice of the venom and adequate venom preparations and maintenance doses are used, is a treatment of great value in preventing systemic reactions to Hymenoptera stings. Read More

    Delayed diagnosis in X-linked agammaglobulinemia and its relationship to the occurrence of mutations in BTK non-kinase domains.
    Expert Rev Clin Immunol 2018 Jan 11;14(1):83-93. Epub 2017 Dec 11.
    a Unidad de Investigación en Inmunodeficiencias , Instituto Nacional de Pediatría, SSA , Ciudad de México , Mexico.
    Background: X-linked agammaglobulinemia (XLA) is characterized by the absence of immunoglobulin and B cells. Patients suffer from recurrent bacterial infections from early childhood, and require lifelong immunoglobulin replacement therapy. Mutations in BTK (Bruton's Tyrosine Kinase) are associated with this phenotype. Read More

    Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review.
    Expert Rev Clin Immunol 2018 Jan 11;14(1):69-82. Epub 2017 Dec 11.
    b Rheumatology Unit, Department of Internal Medicine , ASST-Fatebenefratelli L. Sacco University Hospital , Milan , Italy.
    Background: Interstitial lung diseases (ILDs) are among the most serious complications associated with systemic rheumatic diseases, and lead to significant morbidity and mortality; they may also be the first manifestation of connective tissue diseases (CTDs). The aim of this narrative review is to summarise the data concerning the pathogenesis of CTD/ILD and its distinguishing features in different rheumatic diseseas. Areas covered: The pathogenesis, clinical aspects and treatment of ILD associated with rheumatic systemic diseases and CTDs were reviewed by searching the PubMed, Medline, and Cochrane Library databases for papers published between 1995 and February 2017 using combinations of words or terms. Read More

    Focussing on the foot in psoriatic arthritis: pathology and management options.
    Expert Rev Clin Immunol 2018 Jan 9;14(1):21-28. Epub 2017 Dec 9.
    a Leeds Institute of Rheumatic and Musculoskeletal Medicine , University of Leeds, Chapel Allerton Hospital , Leeds , UK.
    Introduction: Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory arthritis characterised by a range of musculoskeletal conditions including enthesitis, dactylitis and synovitis as well as skin and nail manifestations. The foot is a complex mixture of tissues, all of which can be involved in this disease and is frequently the presenting feature. Areas covered: In this under-researched area, articles were reviewed from the authors' publications as well as from other known authors. Read More

    Up-regulation of chemokine CXCL13 in systemic candidiasis.
    Clin Immunol 2017 Nov 30. Epub 2017 Nov 30.
    Department of Clinical Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:
    Candida albicans is the leading cause of healthcare associated bloodstream infections. Chemokine CXCL13 is well-known involved in inflammation, but its role in candidemia has not been assessed. Our study firstly demonstrated that serum CXCL13 levels were significantly elevated in candidemic patients compared with bacteremic patients and control subjects by ELISA, and CXCL13 concentrations were positively and significantly correlated with clinical Sequential Organ Failure Assessment (SOFA) scores and several laboratory parameters in patients. Read More

    Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma.
    Clin Immunol 2017 Nov 28. Epub 2017 Nov 28.
    Université Paris Descartes, Paris, France; Laboratory of Immunoregulation and Immunopathology, INEM (Institut Necker-Enfants Malades), CNRS UMR8253, and INSERM UMR1151, Paris, France. Electronic address:
    IL-17 and mucosal-associated invariant T (MAIT) cells have been involved in asthma pathogenesis. However, IL-17-producing MAIT cells (MAIT-17) were not evidenced. We aimed to determine whether circulating MAIT-17 were detectable in children with asthma, and whether they correlated with asthma symptoms or lung function. Read More

    Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].
    Clin Immunol 2017 Dec 7. Epub 2017 Dec 7.
    Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

    Subcutaneous immunoglobulins in patients with multiple myeloma and secondary hypogammaglobulinemia.
    Clin Immunol 2017 Nov 27. Epub 2017 Nov 27.
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School, Bari, Italy. Electronic address:
    Multiple myeloma is commonly associated with a reduction of non-paraprotein immunoglobulins, resulting in a higher risk of infections that represent the leading cause of the patients' death. Therefore, immunoglobulin replacement therapy appears a logical approach. A total number of 46 myeloma patients were enrolled: 24 of them were assigned to receive subcutaneous immunoglobulins, and 22 were controls. Read More

    The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.
    Clin Immunol 2017 Nov 26. Epub 2017 Nov 26.
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan.
    Mucus hypersecretion and eosinophil infiltration are important characteristics of eosinophilic inflammation in upper airways, such as allergic rhinitis and chronic rhinosinusitis with nasal polyp. EGFR transactivation induces mucus and inflammatory cytokine secretion from airway epithelial cells. However, the roles of EGFR in eosinophilic inflammation in upper airways are still unknown. Read More

    An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes.
    Clin Immunol 2017 Nov 26. Epub 2017 Nov 26.
    Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:
    The proinflammatory protease caspase-1 plays pivotal roles in central pathways of innate immunity, thereby contributing to pathogen clearance. Beside its physiological role, dysregulated activity of caspase-1 is known to contribute to an increasing number of diseases. In this study, we optimized and validated a low-volume human whole blood assay facilitating the measurement of caspase-1 activation and inflammasome-related gene expression upon stimulation of the NLRP3, NLRC4 or AIM2 inflammasome. Read More

    Taking a prebiotic approach to early immunomodulation for allergy prevention.
    Expert Rev Clin Immunol 2018 Jan 1;14(1):43-51. Epub 2017 Dec 1.
    a School of Medicine , University of Western Australia , Crawley , Australia.
    Introduction: With increasing focus on nutritional strategies to counter the rising global burden of allergic disease, there has been a particular focus on prebiotic nutrients that are selectively utilized by host microorganisms to confer potential immunomodulatory benefits for disease prevention. Areas covered: In this review we examine maternal and infant dietary sources of prebiotics with a particular focus on non-digestible oligosaccharides, which undergo microbial fermentation by commensal gut bacteria to produce short chain fatty acids (SCFA). We summarize the major proposed health benefits of SCFA in early life immune development, together with the current evidence for maternal and/or infant prebiotic consumption in abrogating the risk of early childhood allergic diseases. Read More

    A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID).
    Clin Immunol 2017 Nov 24. Epub 2017 Nov 24.
    Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK.
    Common variable immunodeficiency (CVID) is characterised by repeated infection associated with primary acquired hypogammaglobulinemia. CVID frequently has a complex aetiology but, in certain cases, it has a monogenic cause. Recently, variants within the gene encoding the transcription factor STAT3 were implicated in monogenic CVID. Read More

    Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus.
    Clin Immunol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Neuropsychiatric systemic lupus erythematosus (NPSLE) is often difficult to diagnose and distinguish from other diseases, because no NPSLE-specific antibodies have been identified. We developed a novel proteomic strategy for identifying and profiling antigens in immune complexes in the cerebrospinal fluid (CSF), and applied this strategy to 26 NPSLE patients. As controls, we also included 25 SLE patients without neuropsychiatric manifestations (SLE), 15 with relapsing remitting multiple sclerosis (MS) and 10 with normal pressure hydrocephalus (NPH). Read More

    mTOR inhibitor rapamycin induce polymorphonuclear myeloid-derived suppressor cells mobilization and function in protecting against acute graft-versus-host disease after bone marrow transplantation.
    Clin Immunol 2017 Nov 10. Epub 2017 Nov 10.
    Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Institute of Hematology, Zhejiang University, Hangzhou, China. Electronic address:
    The mammalian target of rapamycin (mTOR) inhibitor rapamycin (RAPA) has been shown to be an effective immunosuppressor in the management of acute graft-versus-host disease (aGVHD) after bone marrow transplantation. Myeloid-derived suppressor cells (MDSCs) also have a protective effect in aGVHD regulation. However, the relationship between RAPA and MDSCs in aGVHD models is unclear. Read More

    Treatment of chronic spontaneous urticaria: Immunomodulatory approaches.
    Clin Immunol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Dermatology, Saint-Luc University Hospital, Université catholique de Louvain, Brussels, Belgium; Institute of Experimental and Clinical Research, Pole of Pneumology, ENT and Dermatology, Université catholique de Louvain, Brussels, Belgium.
    This paper summarizes and reviews the mechanisms of action and data concerning efficacy of recommended treatments as well as other treatments that have been tested, independently of the outcomes, in the management of chronic spontaneous urticaria. Due to the central role of mast cells, basophils and histamine in the pathophysiology of this disease, H1-antihistamines remain the first-line treatment. However, current knowledge about this complex disease, also recognizes an important role for T lymphocytes, B lymphocytes, and autoantibodies. Read More

    Enhanced activation of circulating plasmacytoid dendritic cells in patients with Chronic Obstructive Pulmonary Disease and experimental smoking-induced emphysema.
    Clin Immunol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address:
    Plasmacytoid dendritic cells (pDCs) are key cells bridging the innate with adaptive immunity. However, the phenotypic characteristics of circulating pDCs and its role in smoking related-Chronic Obstructive Pulmonary Disease (COPD) remain largely unknown. The aim of this study was analyzed the phenotype of circulating pDCs and the expression of IFN-γ producing CD8+T cells and IL-17-producing CD8+T cells in patients with COPD by using multi-colour flow cytometry. Read More

    Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4+ T cells of systemic lupus erythematosus.
    Clin Immunol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address:
    DNA hypomethylation plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Here we investigated whether 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis, was involved in regulating DNA hypomethylation and hyper-hydroxymethylation in lupus CD4+ T cells. Our results showed that BDH2 expression was decreased, intracellular iron was increased, global DNA hydroxymethylation level was elevated, while methylation level was reduced in lupus CD4+ T cells compared with healthy controls. Read More

    Reprint of "Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis".
    Clin Immunol 2017 Dec 28;185:119-127. Epub 2017 Oct 28.
    Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Munich, Germany. Electronic address:
    Induction therapy of proliferative lupus nephritis still requires the use of unselective immunosuppressive drugs with significant toxicities. In search of more specific drugs with equal efficacy but fewer side effects we considered blocking pro-inflammatory chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) and homeostatic chemokine stromal cell-derived factor-1 (SDF-1/CXCL12), which both contribute to the onset and progression of proliferative lupus nephritis yet through different mechanisms. We hypothesized that dual antagonism could be as potent on lupus nephritis as the unselective immunosuppressant cyclophosphamide (CYC). Read More

    The impact of biologic agents on health-related quality of life outcomes in patients with psoriasis.
    Expert Rev Clin Immunol 2018 Jan 22;14(1):1-19. Epub 2017 Nov 22.
    a Division of Dermatology , Baylor University Medical Center , Dallas , TX , USA.
    Introduction: Psoriasis is a common, immune-mediated skin disease often associated with significant physical and psychosocial impairment. Antipsoriatic biologic agents offer patients unparalleled treatment potential in regard to greater skin clearance and overall improved quality of life. Evaluation of the therapeutic efficacy of biologic agents on the full psoriasis disease burden must account for their impact on both physical symptoms, as well as patient-reported, health-related quality of life (HRQoL) measurements. Read More

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