4,921 results match your criteria Clinical Immunology[Journal]


Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

Treatment of murine lupus with TIGIT-Ig.

Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China; Team SMMU-China of International Genetically Engineered Machine (iGEM) competitions, Department of Biophysics, Second Military Medical University, Shanghai 200433, China. Electronic address:

The TIGIT (T cell immunoreceptor with Ig and ITIM domains) protein is a co-inhibitory receptor that has been reported to suppress autoreactive T and B cells to trigger immunological tolerance. We generated a new recombinant protein by connecting the extracellular domain of murine TIGIT to the Fc region of the rat immunoglobulin IgG2a. The fusion protein was then characterized. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.007DOI Listing

Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department for Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Some patients diagnosed with common variable immunodeficiency (CVID) actually suffer from combined immunodeficiency (CID) and therefore may require a different, CID-adapted treatment. Several CD4 T-cell-based criteria have been proposed in the past to identify patients with CID within the cohort of adult CVID patients. In this monocentric study, we used retrospective immunological and clinical data of 238 CVID patients to compare four different proposals of how to define CID among CVID patients. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.001DOI Listing

Effect of Withania somnifer on CD38 expression on CD8+ T lymphocytes among patients of HIV infection.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

National HIV/AIDS Reference Laboratory, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

CD38 on CD8 + T cells is considered a reliable marker of HIV disease progression. Withania somnifer, a traditional ayurvedic medicine, has Th1 immunomodulatory properties. PBMCs from 38 HIV patients were exposed to Withania somnifer root extract at standardized concentration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616193009
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http://dx.doi.org/10.1016/j.clim.2019.04.003DOI Listing
April 2019
1 Read

Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients.

Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. Electronic address:

Neuroblastoma is one of the children's malignant tumors with poor prognosis, as well as high recurrence and metastasis rates after surgical removal and chemotherapy. γδ T-cell based immunotherapy receives increasing attention thanks to their strong cytolytic activity to tumor cells. Our previous data revealed a significant increase in circulating γδ T-cell frequency in NB patients. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.006DOI Listing

Tofacitinib for the treatment of rheumatoid arthritis: an update.

Authors:
Kunihiro Yamaoka

Expert Rev Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

a Department of Rheumatology and Infectious Diseases , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara , Kanagawa , 252-0374 Japan.

Introduction: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1607298DOI Listing
April 2019
2 Reads

Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update.

Expert Rev Clin Immunol 2019 Apr 16. Epub 2019 Apr 16.

a The First Department of Internal Medicine , University of Occupational and Environmental Health , Japan.

Introduction: JAK, which constitutively binds to some cytokine receptors, plays an important role in cytokine signaling. While JAK is comprised of JAK1, JAK2, JAK3, and Tyk2, more than 40 types of cytokines transmit signals through JAK. Baricitinib is reported to be highly effective in the treatment of rheumatoid arthritis (RA) and is the second drug launched as a JAK inhibitor for RA. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1608821DOI Listing
April 2019
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Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias.

Expert Rev Clin Immunol 2019 Apr 16. Epub 2019 Apr 16.

a Departments of Clinical and Translational Science , Creighton University School of Medicine , Omaha , USA.

Introduction: Incisional hernias (IH) arise as a complication of patients undergoing a laparotomy. Current literature has assessed the role of extracellular matrix (ECM) disorganization, alterations in type I and type III collagen, matrix metalloproteinases, and tissue inhibitors of metalloproteases on IH. However, there is limited information on the underlying molecular mechanisms that lead to ECM disorganization. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1608822DOI Listing

Pathogenic roles of anti-C1q antibodies in recurrent pregnancy loss.

Clin Immunol 2019 Apr 8;203:37-44. Epub 2019 Apr 8.

Department of Rheumatology, Endocrinology and Nephrology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan.

Recurrent pregnancy loss (RPL) is often considered idiopathic, however excessive complement activation has been observed in pregnancy related manifestations. Anti-C1q antibodies (anti-C1q) are associated with the activation of complement pathway in lupus patients, while it remains unclear in RPL. Firstly, we showed that both the prevalence and titre of anti-C1q were significantly higher in unexplained RPL than in healthy parous individuals. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.005DOI Listing
April 2019
2 Reads

MCC950 blocks enhanced interleukin-1β production in patients with NLRP3 low penetrance variants.

Clin Immunol 2019 Apr 8;203:45-52. Epub 2019 Apr 8.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximillian University, Munich, Germany.

Objective: To determine the role of the NLRP3 inflammasome by using the selective NLRP3 inhibitor MCC950 in patients with NLRP3 low penetrance variants and clinical symptoms suggestive for an autoinflammatory syndrome including central nervous system (CNS) involvement.

Methods: Nineteen symptomatic patients with low penetrance NLRP3 variants (Q703K n = 17, V198M n = 2) recruited between 2011 and 2017 were included in this monocentric study. A functional inflammasome activation assay was performed in patients in comparison to healthy controls (HC), including the determination of interleukin-1beta (IL-1β), interleukin-6 (IL-6) and tumor-necrosis factor alpha (TNF-α) secretion in the presence of the NLRP3 selective small-molecule inhibitor MCC950. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.004DOI Listing

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.

Clin Immunol 2019 Apr 3;203:23-27. Epub 2019 Apr 3.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address:

Genetic studies are identifying an increasing number of monogenic causes of Common Variable Immunodeficiency (CVID). Pathogenic variants in the C-terminus of NFKB2 have been identified in the subset of CVID patients whose immunodeficiency is associated with ectodermal dysplasia and central adrenal insufficiency. We describe 2 unrelated CVID pedigrees with 4 cases of pathogenic stop gain variants (c. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.010DOI Listing
April 2019
2 Reads

Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults.

Clin Immunol 2019 Apr 4;203:14-22. Epub 2019 Apr 4.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA; Molecular Microbiology and Immunology Department, University of Maryland Graduate Program in Life Sciences, Baltimore, MD, USA; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Typhoid fever, caused by the pathogen Salmonella enterica serovar Typhi (S. Typhi), is a serious global health concern. Challenge studies with wild type S. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.002DOI Listing
April 2019
3 Reads

Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome.

Clin Immunol 2019 Apr 2;203:9-13. Epub 2019 Apr 2.

Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address:

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is one of the inborn errors of immunity, characterized by impaired function of the regulatory T cells. Clinical manifestations of IPEX syndrome are characterized by various autoimmune diseases with autoantibodies. The comprehensive analysis for autoantibodies using human proteome microarrays in the four patients with IPEX syndrome was performed. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.011DOI Listing
April 2019
2 Reads

Clinical and economic aspects of newborn screening for severe combined immunodeficiency: DEPISTREC study results.

Clin Immunol 2019 Apr 1;202:33-39. Epub 2019 Apr 1.

Laboratoire d'Immunologie, CHU Nantes, Nantes, France.

Purpose: Severe combined immunodeficiency (SCID) refers to a group of genetic disorders characterized by greatly compromised cellular and humoral immunity. Children with SCID are asymptomatic at birth, but they die from infections within the first months of life if not treated. Quantification of T-cell receptor excision circles is an extremely sensitive screening method for detecting newborns who may have SCID. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.012DOI Listing
April 2019
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Cannabis allergy: what the clinician needs to know in 2019.

Expert Rev Clin Immunol 2019 Apr 4:1-8. Epub 2019 Apr 4.

a Department of Immunology-Allergology-Rheumatology , Antwerp University Hospital, University of Antwerp , Antwerp , Belgium.

Introduction: Although the use of cannabis dates back millennia, the first description of cannabis allergy is relatively recent (1971). Recent large-scale data show that cannabis allergy can manifest severe and generalized symptoms with extensive cross-reactions. Thus, it is essential to become familiarized with its clinical presentation, diagnostic aids, and adequate therapeutic guidance. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1600403DOI Listing
April 2019
3 Reads

Clinical outcomes and predictors of maternal and fetal complications in pregnancies of patients with systemic lupus erythematosus.

Expert Rev Clin Immunol 2019 Apr 1:1-11. Epub 2019 Apr 1.

a Department of Medicine - DIMED, Division of Rheumatology , University of Padova , Padova , Italy.

Introduction: Systemic Lupus Erythematosus (SLE) mostly affects women during their childbearing years. Fertility is preserved in SLE patients, but pregnancy is often characterized by a high number of maternal and fetal complications. Adverse pregnancy outcomes (APO) have been widely studied over the last decades and several investigators have focused on the potential clinical and serological predictors of maternal and fetal complications. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1601557DOI Listing
April 2019
2 Reads

DNA damage accumulation, defective chromatin organization and deficient DNA repair capacity in patients with rheumatoid arthritis.

Clin Immunol 2019 Mar 28;203:28-36. Epub 2019 Mar 28.

First Department of Propaedeutic Internal Medicine and Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address:

We investigated the DNA damage response and repair network in 18 patients with active rheumatoid arthritis and tested the hypothesis that treatment influences this network. A 3-fold increase of endogenous DNA damage (single- and double-strand breaks) was detected in patient-derived peripheral blood mononuclear cells than controls (alkaline comet assay; mean ± SD Olive Tail Moment of 11.8 ± 7. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.009DOI Listing
March 2019
2 Reads

Innate lymphoid cell disturbance with increase in ILC1 in systemic lupus erythematosus.

Clin Immunol 2019 Mar 26;202:49-58. Epub 2019 Mar 26.

Division of Rheumatology and Center of Inflammation, Immunology and Regenerative Medicine, USA; Department of Medicine, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908-0133, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908-0133, USA.

The innate lymphoid cell (ILC) is a group of effector cells with diverse important cellular functions in both health and disease states. In comparison with healthy controls, there were increases in circulating ILC in SLE patients. The proportion of ILC1 significantly increased with significant decreases of ILC2 in SLE patients and ILC3 in SLE patients with moderate to severe activity. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.008DOI Listing
March 2019
1 Read

Epithelial physical barrier defects in chronic rhinosinusitis.

Expert Rev Clin Immunol 2019 Mar 29:1-10. Epub 2019 Mar 29.

a Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital , Capital Medical University , Beijing , China.

Introduction: Chronic rhinosinusitis (CRS) is a common upper airway disease with a prevalence of greater than 10% of the general population. Although the pathogenesis of CRS remains poorly understood, there is growing evidence indicating that epithelial physical barrier defects play an important role in CRS pathogenesis. Areas covered: Epithelial physical barriers are maintained by various intercellular junctions, especially tight junctions (TJs). Read More

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http://dx.doi.org/10.1080/1744666X.2019.1601556DOI Listing
March 2019
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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases.

Clin Immunol 2019 Mar 25;203:1-8. Epub 2019 Mar 25.

Department of Medicine 'B' and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Laboratory of the Mosaics of Autoimmunity, Saint Petersburg University, Saint Petersburg, Russian Federation. Electronic address:

Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.

Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.

Results: The patient mean age was 43 ± 17 years and 89% were female. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.007DOI Listing
March 2019
3 Reads

Guselkumab for the treatment of adults with moderate to severe plaque psoriasis.

Authors:
Lluís Puig

Expert Rev Clin Immunol 2019 Mar 28:1-9. Epub 2019 Mar 28.

a Department of Dermatology, Hospital de la Santa Creu i Sant Pau , Universitat Autònoma de Barcelona , Barcelona , Spain.

Introduction: Guselkumab is a subcutaneously administered monoclonal antibody that targets the IL-23p19 cytokine subunit and has been approved by the US FDA and the EMA for the treatment of moderate-to-severe psoriasis in adult patients. Areas covered: This review outlines the pharmacologic properties, efficacy and safety of guselkumab for the treatment of moderate-to-severe plaque psoriasis in adults. Expert opinion: In clinical trials, guselkumab markedly improved disease, regardless of topographical locations and patient subpopulations, with corresponding improvements in quality of life measures, and was generally well tolerated. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1601014DOI Listing

Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B.

Clin Immunol 2019 Mar 23;202:40-48. Epub 2019 Mar 23.

School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro Nano Biomaterials and Detection Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China. Electronic address:

γδ T cells are a unique population of lymphocytes that have regulatory roles in patients with chronic hepatitis B (CHB); however, their role in acute hepatitis B (AHB) infection remains unclear. Phenotype and function of γδ T cells were analyzed in 29 AHB patients, 28 CHB patients, and 30 healthy controls (HCs) using immunofunctional assays. Compared with HCs and CHB patients, decreased peripheral and increased hepatic γδ T cells were found in AHB patients. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.005DOI Listing

The inhibitory receptors on NK cells and CTLs are upregulated in adult and adolescent patients with secondary hemophagocytic lymphohistiocytosis.

Clin Immunol 2019 Mar 23;202:18-28. Epub 2019 Mar 23.

Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address:

Hemophagocytic lymphohistiocytosis (HLH) includes primary HLH (pHLH) and secondary HLH (sHLH). Mutations that cause abnormal functions in natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are frequently identified in pHLH. However, why NK cells and CTLs exhibit abnormal functions in sHLH remains unclear. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.006DOI Listing

Mediterranean fever gene variants and colchicine therapy in periodic fever, aphthous stomatitis pharyngitis, adenitis syndrome in a Mediterranean region.

Expert Rev Clin Immunol 2019 May 19;15(5):571-575. Epub 2019 Mar 19.

b Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Disease , Cukurova University , Adana , Turkey.

Objectives: Periodic fever, aphthous stomatitis, pharyngitis, adenitis syndrome is characterized by recurrent episodes of fever. Attenuated disease severity was considered in patients with Mediterranean fever (MEFV) gene variations. Corticosteroids are highly effective in controlling the symptoms but usually cause more frequent episodes. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1591275DOI Listing
May 2019
2 Reads

Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

Expert Rev Clin Immunol 2019 Mar 18:1-18. Epub 2019 Mar 18.

e Department of Otolaryngology , Beijing Electric Power Hospital , Beijing , China.

Introduction: An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by immunoglobulin E (IgE), but are also stimulated (not activated) by immune, drug, environmental, food, infectious, and stress triggers, leading to secretion of multiple mediators often without histamine and tryptase. The presentation, diagnosis, and management of the spectrum of mast cell disorders are very confusing. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1596800DOI Listing
March 2019
1 Read

Implications for redefining the dense fine speckled and related indirect immunofluorescence patterns.

Expert Rev Clin Immunol 2019 May 29;15(5):447-448. Epub 2019 Mar 29.

d Cumming School of Medicine , University of Calgary , Calgary , Canada.

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http://dx.doi.org/10.1080/1744666X.2019.1596802DOI Listing

The long-awaited 'pseudo-DFS pattern'.

Expert Rev Clin Immunol 2019 May 29;15(5):445. Epub 2019 Mar 29.

a Laboratorio Immunologia e Allergologia , Ospedale S. Giovanni di Dio, Firenze , Italy.

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http://dx.doi.org/10.1080/1744666X.2019.1596801DOI Listing
May 2019
2 Reads

Predicting uveitis in juvenile idiopathic arthritis: from biomarkers to clinical practice.

Expert Rev Clin Immunol 2019 Mar 15:1-10. Epub 2019 Mar 15.

a Department of Ophthalmology, University Medical Center Utrecht , Utrecht University , Utrecht , The Netherlands.

Introduction: Uveitis is a sight-threatening eye inflammation and common manifestation of juvenile idiopathic arthritis (JIA). New biomarkers that can predict uveitis are needed to alleviate personalized clinical screening. In this review, we outline clinical and molecular risk factors for uveitis and discuss their putative biology and value for clinical practice. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1593139DOI Listing
March 2019
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The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.

Expert Rev Clin Immunol 2019 Mar 15:1-9. Epub 2019 Mar 15.

c Division of Rheumatology and Clinical Immunology, Department of Medicine , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies production and immune complex deposition with systemic clinical manifestations. Interleukin (IL)-17-producing cells play a crucial role in disease pathogenesis and represent an attractive therapeutic target. Areas covered: This review provides an update on the possibility of targeting IL-17 in SLE. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1593141DOI Listing
March 2019
6 Reads

Prediction of treatment outcome and relapse in inflammatory bowel disease.

Expert Rev Clin Immunol 2019 Mar 15:1-11. Epub 2019 Mar 15.

c Department of Gastroenterology and Hepatology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Introduction: Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergoing endoscopy for the purpose is sometimes invasive and burdensome to patients, the performance of surrogate biomarkers has been investigated. Areas covered: We particularly featured the performance of patient symptoms, blood markers including C-reactive protein (CRP), fecal markers including fecal calprotectin (Fcal) and fecal immunochemical test (FIT) for prediction of endoscopic mucosal healing (MH) and prediction of relapse. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1593140DOI Listing
March 2019
9 Reads

Epicutaneous peanut patch device for the treatment of peanut allergy.

Expert Rev Clin Immunol 2019 May 27;15(5):449-460. Epub 2019 Mar 27.

a Department of Allergy and Immunology , Centre Hospitalier Universitaire Sainte-Justine , Montreal , QC , Canada.

Introduction: Food allergy prevalence has increased in recent decades, which has mobilized efforts to develop treatment alternatives. Epicutaneous immunotherapy (EPIT) is a novel method that involves transdermal administration of peanut allergen with the objective to induce tolerance. Recent clinical trials have shown its efficacy at increasing the eliciting dose in children with a favorable safety profile. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1593138DOI Listing
May 2019
2 Reads

Cell mediated immune responses elicited in volunteers following immunization with candidate live oral Salmonella enterica serovar Paratyphi A attenuated vaccine strain CVD 1902.

Clin Immunol 2019 Apr 5;201:61-69. Epub 2019 Mar 5.

Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Medicine, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

The incidence of Salmonella enterica serovar Paratyphi A (PA) infection is on the rise and no licensed vaccines are available. We evaluated cell mediated immune (CMI) responses elicited in volunteers following immunization with a single dose (10 or 10 cfu) of a novel attenuated live oral PA-vaccine strain (CVD 1902). Results showed increases in PA-lipopolysaccharide-specific IgG- and/or IgA B-memory cells and production of IFN-γ, TNF-α, IL-10, IL-23 and RANTES following stimulation with PA-antigens by peripheral blood mononuclear cells obtained 28 days post immunization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616193001
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http://dx.doi.org/10.1016/j.clim.2019.03.003DOI Listing
April 2019
6 Reads

Crosstalk between macrophage and T cell in atherosclerosis: Potential therapeutic targets for cardiovascular diseases.

Clin Immunol 2019 Mar 4;202:11-17. Epub 2019 Mar 4.

Department of cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300192, China. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.03.001DOI Listing

Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro.

Clin Immunol 2019 Apr 4;201:70-78. Epub 2019 Mar 4.

Division of Endocrinology, Diabetes, and Metabolism, The Pennsylvania State University, College of Medicine, Hershey, PA, USA. Electronic address:

We sought evidence for direct effects of repository corticotropin (RCI; an FDA-approved treatment for selected cases of SLE) on isolated human B lymphocytes activated by engagement of TLR9 and B cell receptors. ODN 2395/αIgM treatment was found to result in induction of 162 distinct mRNAs and suppression of 80 mRNAs at 24 h. RCI treatment resulted in suppression of 14 of the ODN 2395/αIgM -induced mRNAs (mean suppression to 23. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.009DOI Listing

Compendium of synovial signatures identifies pathologic characteristics for predicting treatment response in rheumatoid arthritis patients.

Clin Immunol 2019 Mar 1;202:1-10. Epub 2019 Mar 1.

Department of Computer Science, University of California at Davis, California, United States; Genome Center, University of California at Davis, California, United States. Electronic address:

Rheumatoid arthritis (RA) is therapeutically challenging due to patient heterogeneity and variability. Herein we describe a novel integration of RA synovial genome-scale transcriptomic profiling of different patient cohorts that can be used to provide predictive insights on drug responses. A normalized compendium consisting of 256 RA synovial samples that cover an intersection of 11,769 genes from 11 datasets was build and compared with similar datasets derived from OA patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.002DOI Listing
March 2019
2 Reads

Initial safety analysis of a randomized phase II trial of nelipepimut-S + GM-CSF and trastuzumab compared to trastuzumab alone to prevent recurrence in breast cancer patients with HER2 low-expressing tumors.

Clin Immunol 2019 Apr 25;201:48-54. Epub 2019 Feb 25.

Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA. Electronic address:

The development of HER2-targeted therapy has decreased recurrence rates and improved survival, transforming the natural history of HER2-positive breast cancer. However only a minority of breast cancer patients benefit as these agents are not used in patients with tumors expressing low levels of HER2. Preclinical data suggests a synergistic action of HER2-targeted vaccination with trastuzumab. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.011DOI Listing
April 2019
2 Reads

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort.

Clin Immunol 2019 Apr 26;201:55-60. Epub 2019 Feb 26.

Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. Electronic address:

Background: We examined NK cell phenotypes and functions after seven years of ART and undetectable viral loads (<50 copies/ml) with restored CD4 T-cell counts (≥500 cells/μl) and age-matched healthy-HIV-uninfected individuals from the same community.

Methods: Using flow-cytometry, NK cell phenotypes were described using lineage markers (CD56CD16). NK cell activation was determined by expression of activation receptors (NKG2D, NKp44 and NKp46) and activation marker CD69. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448528PMC
April 2019
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Identification and mutational analysis of continuous, immunodominant epitopes of the major oyster allergen Crag 1.

Clin Immunol 2019 Apr 23;201:20-29. Epub 2019 Feb 23.

Beijing Engineering Research Center of Protein & Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing 100015, PR China. Electronic address:

Shellfish, including oysters, often cause allergic reactions in children and adults. Oysters are inevitably consumed because of its delicacy and nutritional benefit, leading to frequent occurrence of severe clinical symptoms observed in patients with oyster hypersensitivity. We aimed to identify the immunodominant epitopes of oyster tropomyosin and crucial amino acids for IgE binding, which will help us to further understand the immunochemical characteristics of Cra g 1. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.008DOI Listing
April 2019
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Avatrombopag for the treatment of immune thrombocytopenia.

Expert Rev Clin Immunol 2019 Apr 8;15(4):327-339. Epub 2019 Mar 8.

a Department of Hematology , Jagiellonian University , Krakow , Poland.

Introduction: Thrombopoietin-receptor agonists (TPO-RAs) are the only American Society of Hematology (ASH) guideline-advocated, second-line treatment for immune thrombocytopenia (ITP) that have been validated by randomized, controlled trials with a placebo comparator. Avatrombopag is a new candidate in this class that has been investigated as a treatment option for the treatment of ITP. Areas covered: In this Drug Profile, we provide a review of the clinical data of avatrombopag, which was approved in May 2018 by the United States Food and Drug Administration (FDA) for the treatment of thrombocytopenia in patients with chronic liver disease undergoing an invasive procedure, and an opinion of its potential place in the current evidence-based ITP treatment landscape. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1587294DOI Listing
April 2019
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Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

Clin Immunol 2019 Apr 15;201:30-34. Epub 2019 Feb 15.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.006DOI Listing
April 2019
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3.672 Impact Factor

The molecular immunology of human susceptibility to fungal diseases: lessons from single gene defects of immunity.

Authors:
Donald C Vinh

Expert Rev Clin Immunol 2019 May 4;15(5):461-486. Epub 2019 Mar 4.

a Department of Medicine (Division of Infectious Diseases; Division of Allergy & Clinical Immunology), Department of Medical Microbiology, Department of Human Genetics , McGill University Health Centre - Research Institute , Montreal , QC , Canada.

Introduction: Fungal diseases are a threat to human health. Therapies targeting the fungus continue to lead to disappointing results. Strategies targeting the host response represent unexplored opportunities for innovative treatments. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1584038DOI Listing

Cytokines, growth factors and proteases in medium and large vessel vasculitis.

Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, USA.

Giant cell arteritis and Takayasu arteritis are autoimmune vasculitides that cause aneurysm formation and tissue infarction. Extravascular inflammation consists of an intense acute phase response. Deeper understanding of pathogenic events in the vessel wall has highlighted the loss of tissue protective mechanisms, the intrusion of immune cells into "forbidden territory", and the autonomy of self-renewing vasculitic infiltrates. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.007DOI Listing
February 2019
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Stratum corneum interleukin-33 expressions correlate with the degree of lichenification and pruritus in atopic dermatitis lesions.

Clin Immunol 2019 Apr 14;201:1-3. Epub 2019 Feb 14.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.clim.2019.02.006DOI Listing
April 2019
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BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment.

Clin Immunol 2019 Apr 13;201:4-14. Epub 2019 Feb 13.

Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.005DOI Listing
April 2019
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Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.

Clin Immunol 2019 Feb 14;199:18-24. Epub 2019 Feb 14.

Royal Free Hospital, Centre for Rheumatology and Connective Tissue Diseases, UCL, London, UK. Electronic address:

Systemic sclerosis (SSc) is a systemic disease characterized by vasculopathy, progressive fibrosis and autoimmune activation. Tryptophan (Trp) metabolism has been linked to altered immune cell function and to malignancy. We have investigated the role of Trp metabolic pathway in SSc measuring serum Trp, Kynurenine (Kyn) and Trp/Kyn ratio in a cohort of 97 SSc patients and 10 healthy controls. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.009DOI Listing
February 2019
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The importance of early peanut ingestion in the prevention of peanut allergy.

Expert Rev Clin Immunol 2019 May 11;15(5):487-495. Epub 2019 Mar 11.

a Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology , Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Introduction: Peanut allergy appears to have increased in prevalence, is often severe and is typically life-long. Therefore, reducing its incidence through a primary prevention strategy is a priority. Guidelines on peanut introduction have evolved with time and given evidence of peanut allergy risk reduction with early infant ingestion exposure, the current US advice promotes early introduction for infants, particularly targeting those at highest risk. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1582331DOI Listing

Short- and long-term real-world effectiveness of omalizumab in severe allergic asthma: systematic review of 42 studies published 2008-2018.

Expert Rev Clin Immunol 2019 May 14;15(5):553-569. Epub 2019 Feb 14.

a Division of Research , Matrix45 , Tucson , AZ , USA.

Introduction: Omalizumab is a recombinant monoclonal anti-IgE antibody approved in the US as add-on treatment in moderate-to-severe allergic asthma (in severe allergic asthma [SAA] in Europe). A 2016 review of 24 real-world effectiveness studies in SAA published between 2008-2015 concluded that omalizumab was associated with significant improvements in objective and subjective outcomes with benefits extending beyond 2 years. Several new real-world studies have been published since, bringing the total to 42 studies. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1574571DOI Listing
May 2019
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CD25 deficiency: A new conformational mutation prevents the receptor expression on cell surface.

Clin Immunol 2019 Apr 8;201:15-19. Epub 2019 Feb 8.

Department of "NEUROFARBA", Section of Child's Health, University of Florence, Italy; Department of Haematology-Oncology "Anna Meyer" Children's Hospital, Florence, Italy. Electronic address:

CD25 deficiency is a very rare autosomal recessive disorder that shows a clinical phenotype highly overlapping IPEX syndrome with an increased susceptibility to viral, bacterial, and fungal infections. It is due to mutations in the IL2Rα gene that codes for the α subunit of the IL2 receptor complex. Here we report the characterization of a novel IL2Rα gene mutation leading to a severe protein conformational alteration that abrogates its cell surface expression in a child presenting with early-onset IPEX-like disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183047
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http://dx.doi.org/10.1016/j.clim.2019.02.003DOI Listing
April 2019
11 Reads