4,881 results match your criteria Clinical Immunology[Journal]


Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.006DOI Listing
February 2019

The molecular immunology of human susceptibility to fungal diseases: lessons from single gene defects of immunity.

Authors:
Donald C Vinh

Expert Rev Clin Immunol 2019 Feb 18. Epub 2019 Feb 18.

a Director, Infectious Disease Susceptibility Program, Associate Professor, FRQS Clinician-Scientist, Dept of Medicine (Division of Infect ious Diseases; Division of Allergy & Clinical Immunology), Dept of Medical Microbiology; Dept of Human Genetics , McGill University Health Centre - Research Institute , 1001 Decarie Blvd; Block E; Rm EM3-3230 (Mail Drop: EM3-3211), Montreal , Quebec , Canada H4A 3J1 , Ph (office); x42811 (admin assist); Fax. Email:

Introduction: Fungal diseases are a threat to human health. Therapies targeting the fungus continue to lead to disappointing results. Strategies targeting the host response represent unexplored opportunities for innovative treatments. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1584038DOI Listing
February 2019

Cytokines, growth factors and proteases in medium and large vessel vasculitis.

Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, USA.

Giant cell arteritis and Takayasu arteritis are autoimmune vasculitides that cause aneurysm formation and tissue infarction. Extravascular inflammation consists of an intense acute phase response. Deeper understanding of pathogenic events in the vessel wall has highlighted the loss of tissue protective mechanisms, the intrusion of immune cells into "forbidden territory", and the autonomy of self-renewing vasculitic infiltrates. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.007DOI Listing
February 2019
1 Read

Stratum corneum interleukin-33 expressions correlate with the degree of lichenification and pruritus in atopic dermatitis lesions.

Clin Immunol 2019 Feb 14;201:1-3. Epub 2019 Feb 14.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.clim.2019.02.006DOI Listing
February 2019

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment.

Clin Immunol 2019 Feb 13;201:4-14. Epub 2019 Feb 13.

Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.005DOI Listing
February 2019

Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.

Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Royal Free Hospital, Centre for Rheumatology and Connective Tissue Diseases, UCL, London, UK. Electronic address:

Systemic sclerosis (SSc) is a systemic disease characterized by vasculopathy, progressive fibrosis and autoimmune activation. Tryptophan (Trp) metabolism has been linked to altered immune cell function and to malignancy. We have investigated the role of Trp metabolic pathway in SSc measuring serum Trp, Kynurenine (Kyn) and Trp/Kyn ratio in a cohort of 97 SSc patients and 10 healthy controls. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.009DOI Listing
February 2019
2 Reads

The importance of early peanut ingestion in the prevention of peanut allergy.

Expert Rev Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

a Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai , One Gustave Levy Pl, New York , NY 10128 , USA.

Introduction: Peanut allergy appears to have increased in prevalence, is often severe and is typically life-long. Therefore, reducing its incidence through a primary prevention strategy is a priority. Guidelines on peanut introduction have evolved with time and given evidence of peanut allergy risk reduction with early infant ingestion exposure, the current US advice promotes early introduction for infants, particularly targeting those at highest risk. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1582331DOI Listing
February 2019

Short- and long-term real-world effectiveness of omalizumab in severe allergic asthma: systematic review of 42 studies published 2008-2018.

Expert Rev Clin Immunol 2019 Feb 14:1-17. Epub 2019 Feb 14.

a Division of Research , Matrix45 , Tucson , AZ , USA.

Introduction: Omalizumab is a recombinant monoclonal anti-IgE antibody approved in the US as add-on treatment in moderate-to-severe allergic asthma (in severe allergic asthma [SAA] in Europe). A 2016 review of 24 real-world effectiveness studies in SAA published between 2008-2015 concluded that omalizumab was associated with significant improvements in objective and subjective outcomes with benefits extending beyond 2 years. Several new real-world studies have been published since, bringing the total to 42 studies. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1574571DOI Listing
February 2019

CD25 deficiency: A new conformational mutation prevents the receptor expression on cell surface.

Clin Immunol 2019 Feb 8;201:15-19. Epub 2019 Feb 8.

Department of "NEUROFARBA", Section of Child's Health, University of Florence, Italy; Department of Haematology-Oncology "Anna Meyer" Children's Hospital, Florence, Italy. Electronic address:

CD25 deficiency is a very rare autosomal recessive disorder that shows a clinical phenotype highly overlapping IPEX syndrome with an increased susceptibility to viral, bacterial, and fungal infections. It is due to mutations in the IL2Rα gene that codes for the α subunit of the IL2 receptor complex. Here we report the characterization of a novel IL2Rα gene mutation leading to a severe protein conformational alteration that abrogates its cell surface expression in a child presenting with early-onset IPEX-like disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183047
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http://dx.doi.org/10.1016/j.clim.2019.02.003DOI Listing
February 2019
2 Reads

Genetic and inflammatory factors associated with psoriatic arthritis: Relevance to diagnosis and management.

Clin Immunol 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory musculoskeletal condition with complex pathophysiology. In recent years, understanding of the pathogenesis of PsA has improved substantially. Several genetic and inflammatory factors have been identified and studied as targets for new biologic disease-modifying therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183067
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http://dx.doi.org/10.1016/j.clim.2019.02.001DOI Listing
February 2019
4 Reads

Immune aging in diabetes and its implications in wound healing.

Clin Immunol 2019 Feb 5;200:43-54. Epub 2019 Feb 5.

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Instituto de Investigação Interdisciplinar, University of Coimbra, Coimbra, Portugal; Department of Geriatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, United States.

Immune systems have evolved to recognize and eliminate pathogens and damaged cells. In humans, it is estimated to recognize 10 epitopes and natural selection ensures that clonally expanded cells replace unstimulated cells and overall immune cell numbers remain stationary. But, with age, it faces continuous repertoire restriction and concomitant accumulation of primed cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616193000
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http://dx.doi.org/10.1016/j.clim.2019.02.002DOI Listing
February 2019
3 Reads

Caspse-11-GSDMD pathway is required for serum ferritin secretion in sepsis.

Clin Immunol 2019 Feb 4. Epub 2019 Feb 4.

Department of Hematology, Key Laboratory of non-resolving inflammation and cancer of Human Province, The third Xiangya Hospital, Central South University, Changsha, Hunan Province 410000, PR China; Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan Province 410000, PR China; Key Laboratory of sepsis and translational medicine, School of Basic Medical Science, Central South University, Changsha, Hunan Province 410000, PR China; Department of Pathophysiology, School of Basic Medical Science, Jinan University, Guangzhou, Guangdong Province 510632, PR China. Electronic address:

Ferritin is the major iron storage molecule of vertebrates, which can be detected in serum under numerous conditions, including inflammatory, neurodegenerative, and malignant diseases. Given this character, serum ferritin is frequently used as a biomarker in clinical settings. How the ferritin secreted to the serum has attracted much attention. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.005DOI Listing
February 2019

Abatacept for the treatment of rheumatoid arthritis.

Expert Rev Clin Immunol 2019 Feb 7:1-8. Epub 2019 Feb 7.

b Fundacion Ramon Dominguez, Hospital Clinico Universitario , Santiago de Compostela , Spain.

Introduction: Rheumatoid arthritis (RA) is a complex disease in which different mechanisms are involved. Studies suggest a key role for aberrant pathways of T-cell activation in the initiation and perpetuation of disease. Abatacept is a fusion protein composed of the Fc region of the immunoglobulin G1 (IgG1) fused to the extracellular domain of cytotoxic T lymphocyte-associated antigen (CTLA4). Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1579642DOI Listing
February 2019
3 Reads

Limits of traditional evidence-based medicine methodologies exemplified by the novel era in psoriatic arthritis drug development.

Expert Rev Clin Immunol 2019 Feb 7:1-4. Epub 2019 Feb 7.

a Department of Rheumatology and Clinical Immunology , University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/1744666X.2019.1580144DOI Listing
February 2019
1 Read

Screening children for eosinophilic esophagitis: allergic and other risk factors.

Expert Rev Clin Immunol 2019 Feb 5:1-4. Epub 2019 Feb 5.

a Division of Allergy & Immunology , Children's Hospital of Philadelphia , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/1744666X.2019.1579643DOI Listing
February 2019

HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA).

Clin Immunol 2019 Jan 31;200:66-70. Epub 2019 Jan 31.

Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. Electronic address:

In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T cell epitope measure (iTEM) scoring method predicts patient-specific risk of developing ADA against therapeutic recombinant human GAA (rhGAA) using individualized HLA-binding predictions and GAA genotype. Read More

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http://dx.doi.org/10.1016/j.clim.2019.01.009DOI Listing
January 2019
1 Read

KIR gene haplotype A is associated with hospital mortality in patients with sepsis.

Clin Immunol 2019 Jan 30;200:37-38. Epub 2019 Jan 30.

Cancer and Neurobiology Laboratory, Experimental Research Center, Porto Alegre Clinical Hospital, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

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http://dx.doi.org/10.1016/j.clim.2019.01.008DOI Listing
January 2019

The potential role of CD4CD52 T-cell populations in systemic lupus erythematosus.

Clin Immunol 2019 Jan 30;200:35-36. Epub 2019 Jan 30.

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

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http://dx.doi.org/10.1016/j.clim.2019.01.007DOI Listing
January 2019
1 Read

Precursor B-cell development in bone marrow of Good syndrome patients.

Clin Immunol 2019 Jan 25;200:39-42. Epub 2019 Jan 25.

Dept. of Immunology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Dept. of Pediatrics, Laboratory for Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Good syndrome is an immunodeficiency presenting with thymoma, hypogammaglobulinemia and almost absent B cells. To investigate the origin of the B-cell lymphopenia in these patients, we studied B cell differentiation in the bone marrow of Good syndrome patients. We found very low numbers of precursor B cells in bone marrow of Good syndrome patients and a differentiation arrest after the pro-B-cell stage; this is different from other agammaglobulinemia patients with a defect in pre B-cell receptor signaling. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.009DOI Listing
January 2019
1 Read

Measuring and managing appearance anxiety in patients with systemic sclerosis.

Expert Rev Clin Immunol 2019 Jan 25:1-6. Epub 2019 Jan 25.

b Department of Psychology , San Diego State University , San Diego , CA , USA.

Introduction: Systemic sclerosis (SSc, scleroderma) is a progressive, autoimmune, connective tissue disease of unknown etiology that can cause changes in appearance in socially important areas of the body (e.g. face and hands). Read More

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http://dx.doi.org/10.1080/1744666X.2019.1573673DOI Listing
January 2019
1 Read

CD40 ligand deficiency: treatment strategies and novel therapeutic perspectives.

Expert Rev Clin Immunol 2019 Jan 25:1-12. Epub 2019 Jan 25.

a Department of Immunology, Institute of Biomedical Sciences , University of São Paulo , São Paulo , Brazil.

Introduction: CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here, we discuss clinical and immunological characteristics of CD40L deficiency as well as current therapeutic strategies used for patient management. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1573674DOI Listing
January 2019
5 Reads

B-cell depleting immunotherapies: therapeutic opportunities and toxicities.

Expert Rev Clin Immunol 2019 Feb 6:1-13. Epub 2019 Feb 6.

a Department of Pediatric Hematology and Oncology, Cellular and Gene Therapy , IRCCS Ospedale Pediatrico Bambino Gesù , Rome , Italy.

Introduction: The last few years have witnessed what can certainly be defined as a 'period of renaissance' for immunotherapy in the field of hematological malignancies. In particular, antibody-mediated and cell-mediated immunotherapy have significantly changed the treatment approach of patients with B-cell lymphoproliferative disorders. These therapies, initially employed in patients with refractory/relapsed disease, are now integrated in the treatment of newly diagnosed patients. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1573672DOI Listing
February 2019
1 Read

Belatacept in kidney transplantation and its limitations.

Expert Rev Clin Immunol 2019 Jan 24:1-9. Epub 2019 Jan 24.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes , Grenoble , France.

Introduction: Since the approval of belatacept in 2011 for use in the setting of de novo kidney transplantation, this CD80/86 - CD28 co-stimulation blocker has been shown to be a valuable treatment option for maintenance immunosuppression. Areas covered: In this setting, belatacept has been associated with superior glomerular filtration rate as compared to calcineurin inhibitor-based treatments because of the absence of nephrotoxicity. Additionally, belatacept avoids the cardiovascular side effects (e. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1574570DOI Listing
January 2019
1 Read

Diagnosing autoimmune encephalitis based on clinical features and autoantibody findings.

Authors:
Christian G Bien

Expert Rev Clin Immunol 2019 Jan 24. Epub 2019 Jan 24.

a Epilepsy Center Bethel, Krankenhaus Mara , Maraweg 17-21 33617 Bielefeld , Germany.

Introduction: Autoimmune encephalitides have been accepted as a reproducible and treatable new group of diseases. At present, there is concern that such diagnoses might be made too liberally. Areas covered: This article suggests how to make valid diagnoses. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1573676DOI Listing
January 2019
3 Reads

Pain and affective distress in arthritis: relationship to immunity and inflammation.

Expert Rev Clin Immunol 2019 Jan 23:1-12. Epub 2019 Jan 23.

b Lawson Health Research Institute , London , Ontario , Canada.

Introduction: Most arthritides are associated with pain and psychological distress (clinically significant depression and anxiety). Pain and depression are mutually exacerbating; both may continue even when joint involvement appears well controlled. Area covered: There is strong evidence that arthritis-related stress impacts the central nervous system and, together with peripheral inflammatory changes, can cause central sensitization that can lead to chronic pain and worsening of affective distress. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1573675DOI Listing
January 2019
1 Read

Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.

Clin Immunol 2019 Jan 17. Epub 2019 Jan 17.

The First Clinical College, Shanxi Medical University, Taiyuan 030001, China; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, China; Institute of Brain Science, Shanxi Datong University, Datong 037009, China. Electronic address:

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system characterized by oligodendrocyte loss and progressive neurodegeneration. The cuprizone (CPZ)-induced demyelination is widely used to investigate the demyelination/remyelination. Here, we explored the therapeutic effects of Hydroxyfasudil (HF), an active metabolite of Fasudil, in CPZ model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183046
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http://dx.doi.org/10.1016/j.clim.2019.01.006DOI Listing
January 2019
5 Reads

Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry.

Clin Immunol 2019 Jan 16;200:24-30. Epub 2019 Jan 16.

Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

We investigated the effect of aging on the multi-dimensional characteristics and heterogeneity of human peripheral CD8 T cells defined by the expression of a set of molecules at the single cell level using the recently developed mass cytometry or Cytometry by Time-Of-Flight (CyTOF) and computational algorithms. CD8 T cells of young and older adults had differential expression of molecules, especially those related to cell activation and migration, permitting the clustering of young and older adults through an unbiased approach. The changes in the expression of individual molecules were collectively reflected in the altered high-dimensional profiles of CD8 T cells in older adults as visualized by the dimensionality reduction analysis tools principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183056
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http://dx.doi.org/10.1016/j.clim.2019.01.005DOI Listing
January 2019
4 Reads

Canakinumab for the treatment of hyperimmunoglobulin D syndrome.

Expert Rev Clin Immunol 2019 Mar 26;15(3):215-220. Epub 2019 Jan 26.

b Pediatric Rheumatology Unit, Pediatrics Department, Hospital Sant Joan de Déu , Universitat de Barcelona , Barcelona , Spain.

Introduction: Mevalonate Kinase Deficiency (MKD) is a rare monogenic autoinflammatory disorder (AID) with autosomal recessive inheritance caused by mutations in the MVK gene. It includes hyperimmunoglobulinemia D syndrome (HIDS) and mevalonic aciduria (a severe form). Patients have recurrent inflammatory attacks with high fever, gastrointestinal symptoms, lymphadenopathy, splenomegaly, arthralgia, rash, pharyngitis, aphtosis and constitutional complaints. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1571410DOI Listing
March 2019
6 Reads

B cells and atherosclerosis in systemic lupus erythematosus.

Expert Rev Clin Immunol 2019 Jan 17:1-13. Epub 2019 Jan 17.

a Department of Physiology, School of Medicine , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Cardiovascular (CV) events, as a result of accelerated atherosclerosis, are an important cause of mortality in patients with Systemic lupus erythematosus (SLE). The etiology of SLE is multifactorial and still unclear; among other potential culprits, excessive B cell activation seems to play a crucial role. Accumulating evidence supports a contributory role of B cells in the pathogenesis of atherosclerosis as well. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1571411DOI Listing
January 2019
2 Reads

In seroconverted rheumatoid arthritis patients a multi-reactive anti-herpes IgM profile is associated with disease activity.

Clin Immunol 2019 Jan 11;200:19-23. Epub 2019 Jan 11.

Central Research Laboratory, Kazan Federal University, Kazan, Russia; Laboratory of Immunology and Immunotherapy, INSERM U1227, Hôpital Morvan, Centre Hospitalier Regional Universitaire (CHU) de Brest, Brest, France. Electronic address:

Conflicting results have been reported regarding human herpes virus (HHV) reactivation in patients with rheumatoid arthritis (RA). To explore this link, 74 RA patients were selected and compared to 42 first degree relatives (FDR) from probands with RA and 25 healthy controls from the Tatarstan women cohort. The serological analysis was done by testing anti-HSV/CMV/EBV IgM, IgG, plus the IgG avidity index, and completed by evaluating HSV/CMV/EBV DNA by PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183062
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http://dx.doi.org/10.1016/j.clim.2019.01.004DOI Listing
January 2019
7 Reads

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

Clin Immunol 2019 Jan 9;200:55-63. Epub 2019 Jan 9.

Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, National Jewish Health, Denver, CO 80206, United States. Electronic address:

Ataxia-Telangiectasia (AT) is an immunodeficiency most often associated with T cell abnormalities. We describe a patient with a hyper-IgM phenotype and immune cell abnormalities that suggest a distinct clinical phenotype. Significant B cell abnormalities with increased unswitched memory B cells, decreased naive transitional B cells, and an elevated frequency of CD19CD38CD27CD10CD21 B cells expressing high levels of T-bet and Fas were demonstrated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183062
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http://dx.doi.org/10.1016/j.clim.2019.01.002DOI Listing
January 2019
6 Reads

A novel monoallelic gain of function mutation in p110δ causing atypical activated phosphoinositide 3-kinase δ syndrome (APDS-1).

Clin Immunol 2019 Jan 9;200:31-34. Epub 2019 Jan 9.

Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili of Brescia, Brescia, Italy.

This study reports on a novel activating p110δ mutation causing adult-onset hypogammaglobulinemia with lymphopenia without the classical presentation of atypical Activated phosphoinositide 3-kinase δ syndrome (ADPS-1), underlining thus the heterogeneous clinical and immunological presentation of p110δ mutated individuals and offers additional data on the role of p110δ in early and late B cell development in humans. Read More

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http://dx.doi.org/10.1016/j.clim.2019.01.003DOI Listing
January 2019
5 Reads

Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis.

Expert Rev Clin Immunol 2019 Jan 11:1-15. Epub 2019 Jan 11.

a Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases , ICMiD, Hospital Clínic , Barcelona , Spain.

Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1568240DOI Listing
January 2019
9 Reads

Epidemiology, characterization and diagnosis of neuropsychiatric events in systemic lupus erythematosus.

Expert Rev Clin Immunol 2019 Jan 11. Epub 2019 Jan 11.

b Laboratory of Autoimmune Diseases, School of Medical Science , University of Campinas , Campinas , SP 13083-872 , Brazil.

Introduction: Neuropsychiatric systemic lupus erythematosus (NPSLE) is characterized by a heterogeneity of clinical manifestations. The absence of diagnostic criteria and the lack of clinical trials is a challenge in clinical practice. Areas covered: A literature review was performed to describe epidemiology, characterization (clinical, immunological and imaging), diagnosis and treatment of NPSLE. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1564040DOI Listing
January 2019
2 Reads

Severe combined immunodeficiency (SCID) presenting in childhood, with agammaglobulinemia, associated with novel compound heterozygous mutations in DCLRE1C.

Clin Immunol 2019 Jan 7;200:16-18. Epub 2019 Jan 7.

Department of Clinical Immunology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Immunology, University Hospital Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland. Electronic address:

Severe combined immunodeficiency (SCID) can be caused by deleterious mutations in DCLRE1C, leading to deficient non-homologous end joining by compromising the function of the Artemis protein. This impairs the process of V(D)J recombination of the T- and B-cell receptors and typically results in radiosensitive T, B, NK SCID presenting during the first months of life. We present a case of a 3-year-old girl with two novel compound heterozygous variants in DCLRE1C (c. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.019DOI Listing
January 2019
3 Reads

Anti-DFS70 antibodies: an update on our current understanding and their clinical usefulness.

Expert Rev Clin Immunol 2019 Mar 4;15(3):241-250. Epub 2019 Feb 4.

e Cumming School of Medicine , University of Calgary , Calgary , Canada.

Introduction: Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), there is a growing body of evidence that anti-DFS70 antibodies, when present in high titers and in isolation (without accompanying other antibodies), are useful to aid in the exclusion of ANA associated rheumatic diseases. Areas covered: This review aims to analyze and interpret the current published knowledge and recent findings to provide guidance in the use of anti-DFS70 antibodies to analyze associations of this unique autoantibody. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1562903DOI Listing
March 2019
10 Reads

SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?

Clin Immunol 2018 Oct 25. Epub 2018 Oct 25.

Department of Molecular and Cellular Pathobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine.

SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. It is widely expressed on cells within hematopoietic system. In hematologic malignancies CD150 cell surface expression is restricted to cutaneous T-cell lymphomas, few types of B-cell non-Hodgkin's lymphoma, near half of cases of chronic lymphocytic leukemia, Hodgkin's lymphoma, and multiple myeloma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183043
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http://dx.doi.org/10.1016/j.clim.2018.10.015DOI Listing
October 2018
6 Reads

Management of pregnant women with antiphospholipid antibodies.

Expert Rev Clin Immunol 2019 Jan 8. Epub 2019 Jan 8.

a Rheumatology Unit, Department of Medicine , University Hospital of Padua , Via Giustiniani, 2, 35128 Padua , Italy.

Introduction: Important advancements in pregnancy outcome have been reported in women with antiphospholipid antibodies (aPL), despite the fact that the treatment of aPL related pregnancy morbidity is not guided by consistent findings from well-designed trials. Areas covered: The current study draws a picture of the studies in the literature by performing a Medline search of relevant English language articles and reports our experience in managing different subsets of obstetric antiphospholipid syndrome (APS), defined on the basis of their clinical and laboratory characteristics. The management of pregnant women with non-criteria APS manifestations and that of aPL carriers during their first pregnancy is also examined. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1565995DOI Listing
January 2019
2 Reads

High levels of antibodies to citrullinated α-enolase peptide-1 (CEP-1) identify erosions and interstitial lung disease (ILD) in a Chinese rheumatoid arthritis cohort.

Clin Immunol 2019 Jan 3;200:10-15. Epub 2019 Jan 3.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:

We evaluated the clinical performance of anti-CEP-1 in a Chinese rheumatoid arthritis (RA) cohort. A total of 264 subjects were tested, including 101 RA patients, 38 juvenile idiopathic arthritis (JIA) patients, 46 disease control (DC) and 79 healthy controls (HC). The presence of anti-CEP-1 in patients with RA, JIA, DCs and HC were 61. Read More

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http://dx.doi.org/10.1016/j.clim.2019.01.001DOI Listing
January 2019
2 Reads

Exercise-induced anaphylaxis: causes, consequences, and management recommendations.

Expert Rev Clin Immunol 2019 Mar 9;15(3):265-273. Epub 2019 Jan 9.

a Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA) , Odense University Hospital , Odense , Denmark.

Introduction: Exercise-induced anaphylaxis (EIA) denotes a range of disorders where anaphylaxis occurs in relation to physical exercise. Typical symptoms include flushing, pruritus, urticaria, angioedema, respiratory symptoms, gastrointestinal symptoms, hypotension, and collapse during or after exercise. The far best described entity within EIA is food-dependent exercise-induced anaphylaxis (FDEIA), where symptoms only occur in combination with food intake. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1562904DOI Listing
March 2019
6 Reads

The Immunomodulatory Role of Interleukin-35 in Fibrotic Diseases.

Expert Rev Clin Immunol 2018 Dec 27. Epub 2018 Dec 27.

d Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine , University of Alabama at Birmingham , Birmingham , AL , USA.

Introduction: Fibrosis makes numerous diseases in all organs more complicated and leads to severe consequences in the lung, liver, heart, kidney and skin. In essence, fibrosis results from excessive, persistent and oftentimes nonreversible aggregation of extracellular matrix (ECM) or simply as collagen during the process of tissue injury and repair. Recent studies suggest the pathology of fibrosis, especially in pulmonary and liver fibrosis, involves various types of immune cells and soluble mediators including interleukin (IL)-35, a recently identified heterodimeric cytokine that belongs to the IL-12 cytokine family. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1564041DOI Listing
December 2018
2 Reads
3.342 Impact Factor

Ixekizumab for the treatment of psoriasis: an update on new data since first approval.

Expert Rev Clin Immunol 2018 Dec 27:1-11. Epub 2018 Dec 27.

a Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital , University of Copenhagen , Hellerup , Denmark.

Introduction: Psoriasis is a chronic immune-mediated skin disease with a multifactorial etiology. Studies have shown that the inflammatory cytokine interleukin-17A (IL-17A) is a key mediator in the pathogenesis. Targeted biologics have changed the outcome for patients in a variety of diseases including psoriasis. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1559730DOI Listing
December 2018
2 Reads

Managing immune dysregulation resulting from immune checkpoint inhibitors: impact of the ASCO guidelines and key take-homes for immunologists.

Expert Rev Clin Immunol 2019 Mar 27;15(3):211-213. Epub 2018 Dec 27.

a Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

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http://dx.doi.org/10.1080/1744666X.2019.1559731DOI Listing
March 2019
1 Read

Topical agents for the treatment of atopic dermatitis.

Expert Rev Clin Immunol 2018 Dec 27. Epub 2018 Dec 27.

a Department of Dermatology , Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Introduction: Atopic dermatitis (AD) is perhaps the most common inflammatory skin disorder worldwide, with an increasing incidence in developed countries. The mainstay treatment for patients with AD are topical therapies, which are used not only by the mild patients, but also by the moderate-to-severe patients, in conjunction with systemic treatment. While topical steroids and calcineurin antagonists are widely used, these are associated with long-term cutaneous adverse effects (AEs) or a black box warning, preventing their chronic use. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1564038DOI Listing
December 2018
1 Read

Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis.

Expert Rev Clin Immunol 2019 Mar 24;15(3):303-313. Epub 2019 Jan 24.

a Postgraduate Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine , Maringá State University , Maringá , Brazil.

Background: Psoriatic arthritis (PsA) is a chronic skin and joint condition that considerably affects patient quality of life. Several studies have demonstrated different associations of genetic polymorphisms in the pathogenic process of PsA. Therefore, we conducted a meta-analysis to estimate the effect of polymorphisms in the cytokines TNF, IL12B, IL23A, and IL23R on PsA risk. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1564039DOI Listing
March 2019
13 Reads

Infusion-related reactions to rituximab: frequency, mechanisms and predictors.

Expert Rev Clin Immunol 2018 Dec 24. Epub 2018 Dec 24.

a Département d'Hématologie Clinique , CHRU de Montpellier , Montpellier , France.

Introduction: Rituximab, an anti-CD20 monoclonal antibody (mAb), is indicated in the treatment of B-cell non Hodgkin lymphomas, chronic lymphoid leukemia and rheumatoid arthritis. The occurrence of infusion related reactions (IRR), especially during the first infusion, is one of the main concerns of rituximab, otherwise well tolerated. Although IRR are usually mild to moderate, fatal evolutions have been reported. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1562905DOI Listing
December 2018
2 Reads

Autoimmunity-associated intronic SNP (rs2281808) detected by a simple phenotypic assay: Unique case or broader opportunity?

Clin Immunol 2019 Jan 21;198:57-61. Epub 2018 Dec 21.

Departments of Pathology, University of Iowa Health Care, Iowa City, IA 52242, United States. Electronic address:

Multiple genome-wide association studies have shown that the single-nucleotide polymorphism (SNP) rs2281808 TT variant, present within the signal regulatory protein gamma (SIRPG) gene, is associated with autoimmune diseases, such as type 1 diabetes. SIRPγ is the only SIRP expressed on T cells. The role of SIRPγ in human T-cells or the effect of the TT variant are poorly understood. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361684PMC
January 2019
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Atopic dermatitis: a review of evolving targeted therapies.

Expert Rev Clin Immunol 2019 Mar 14;15(3):275-288. Epub 2019 Jan 14.

a Department of Internal Medicine , University of North Dakota School of Medicine and Health Sciences , Bismarck , ND , USA.

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition, affecting a significant number of patients of all ages. As we learn more about the pathogenesis of AD, new targeted treatment options are being developed to better tailor its management. Currently, a variety of biologic agents are utilized to target specific components and regulators of the inflammatory pathways in allergic and inflammatory conditions. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1560267DOI Listing
March 2019
2 Reads

Type I and II interferons commit to abnormal expression of chemokine receptor on B cells in patients with systemic lupus erythematosus.

Clin Immunol 2018 Dec 19;200:1-9. Epub 2018 Dec 19.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan. Electronic address:

Memory B cells are increased in systemic lupus erythematosus (SLE) cases, but the qualitative abnormalities and induction mechanism of these cells are unclear. Here, we subclassified B cells by their chemokine receptor expression and investigated their induction mechanism. The peripheral blood of patients with SLE showed higher levels of CXCR5 and CXCR3 B cells. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.017DOI Listing
December 2018
3 Reads