2,301 results match your criteria Clinical Hemorheology and Microcirculation [Journal]


Comparison of exercise electrocardiography and magnetocardiography for detection of coronary artery disease using ST-segment fluctuation score.

Clin Hemorheol Microcirc 2019 Feb 8. Epub 2019 Feb 8.

Coburg Hospital, 2nd Medical Department, Coburg, Germany.

Background: Exercise electrocardiography (ECG) is frequently used as a diagnostic measure in patients with suspected coronary artery disease (CAD). However, it has low sensitivity for the detection of CAD. Magnetocardiography (MCG) has been proposed as an alternative tool to accurately diagnose CAD. Read More

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http://dx.doi.org/10.3233/CH-180485DOI Listing
February 2019

Terminologies regarding sickle cell retinopathy and maculopathy.

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Laboratoire d'Excellence GR-Ex ≪ The red cell: from genesis to death ≫, PRES Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.3233/CH-190552DOI Listing
January 2019

Can acoustic structural quantification be used to characterize the ultrasound echotexture of the peripheral zone of breast lesions?

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology and Interdisciplinary Ultrasound Centre and Ultrasound Research Laboratory, University Berlin, Charité, Berlin, Germany.

Background: Besides mammography, breast ultrasound is the most important imaging modality for women with suspected breast cancer. New software tools bear high potential for improved detectability and specification of malignant breast lesions.

Objective: To compare the halo depicted around malignant breast lesions by ultrasound using Acoustic Structure Quantification (ASQ) of raw image data with the echogenic rim seen in B-mode ultrasound. Read More

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http://dx.doi.org/10.3233/CH-180484DOI Listing
January 2019

TAK733 attenuates adrenergic receptor-mediated cardiomyocyte hypertrophy via inhibiting ErkThr188 phosphorylation.

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Gangwon-do, Republic of Korea.

Background: Cardiac hypertrophy is an important risk factor for heart failure. The MEK-ERK axis has been reported as a major regulator in controlling cardiac hypertrophy. TAK733 is a potent and selective MEK inhibitor that suppresses cell growth in a broad range of cell lines. Read More

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http://dx.doi.org/10.3233/CH-180476DOI Listing
January 2019

Effects of dance movement therapy on the rheological properties of blood in elderly women.

Clin Hemorheol Microcirc 2019 Jan 31. Epub 2019 Jan 31.

Department of Physiotherapy, University of Physical Education, Cracow, Poland.

Objective: The aim of this study was to analyse the effects of dance movement therapy exercises (DMT) on the rheological properties of blood in elderly women.

Methods: The study encompassed group of women (mean aged: 67 years), who were subjected to three-month dance movement therapy programme (n = 20). Blood samples from all the women were examined for their haematological, rheological, and biochemical parameters both prior to the study and three months thereafter. Read More

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http://dx.doi.org/10.3233/CH-180470DOI Listing
January 2019
1 Read

Biomarkers of endothelial injury in plasma are dependent on kidney function.

Clin Hemorheol Microcirc 2019 Jan 31. Epub 2019 Jan 31.

Department of Anesthesiology and Intensive Care, and Department of Medical and Health Sciences (IMH), Linköping University, Linköping, Sweden.

Background: Injury (shedding) of the endothelial glycocalyx layer, which alters local blood flow and microvascular permeability, is assessed by measuring components of this layer in circulating blood. The influence of renal function on their concentrations is unknown.

Methods: Plasma and urine concentrations of three shedding products (syndecan-1, hyaluronic acid, and heparan sulfate) and creatinine were measured over 5 hours in 15 healthy volunteers and 15 postoperative patients; this guaranteed a spread of kidney functions. Read More

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http://dx.doi.org/10.3233/CH-180444DOI Listing
January 2019

A study on role and mechanism of TLR4/NF-κB pathway in cognitive impairment induced by cerebral small vascular disease.

Clin Hemorheol Microcirc 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurology, Gansu Provincial People's Hospital, Lanzhou, Gansu, China.

Objective: To investigate the role and potential mechanism of Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway in cognitive impairment induced by cerebral small vascular disease (CSVD), so as to provide a reference for the clinical treatment of CSVD-induced cognitive impairment.

Methods: Mice with TLR4 gene knockout (n = 20) and those with wild-type TLR4 gene (n = 40) aged 8-10 weeks old were divided into blank control group (Control group, n = 20), wild-type + CSVD group (WT + CSVD group, n = 20) and TLR4 gene knockout + CSVD group (TLR4 KO + CSVD group, n = 20). Allogeneic thrombosis (particle diameter: 50-70 mm) was injected to the mouse's external carotid artery to create a model of learning and memory dysfunction. Read More

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http://dx.doi.org/10.3233/CH-180515DOI Listing
January 2019
2 Reads
2.242 Impact Factor

Stiffness distribution in the ablated zone after radiofrequency ablation for liver: An ex-vivo study with a tissue elastometer.

Clin Hemorheol Microcirc 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the stiffness distribution in the ablated zone after radiofrequency ablation (RFA), we used a device called tissue elastometer based on gross liver samples.

Materials: AND METHODS: Twelve freshly excised porcine livers were subject to RFA under a same setup to form elliptic ablated samples. Each sample was cut open for gross examination, and then the surface of the section plane was sliced into one piece for Young's modulus test using the tissue elastometer. Read More

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http://dx.doi.org/10.3233/CH-180404DOI Listing
January 2019
1 Read

Changes of perfusion patterns of surgical wounds under application of closed incision negative pressure wound therapy in postbariatric patients1.

Clin Hemorheol Microcirc 2019 Jan 14. Epub 2019 Jan 14.

Department of Plastic and Hand Surgery University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Negative pressure wound therapy applied over closed incisions (ciNPT) has been shown to influence wound healing. Therefore, the aim of this study was to examine the short-term effects of ciNPT on skin perfusion patterns in postbariatric wounds.

Methods: 17 patients were included. Read More

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http://dx.doi.org/10.3233/CH-180450DOI Listing
January 2019
5 Reads

Evaluation of plasma cell mastitis with superb microvascular imaging.

Clin Hemorheol Microcirc 2018 Jan 9. Epub 2018 Jan 9.

Department of Ultrasound, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China.

Background: Plasma cell mastitis (PCM), a common type of mastitis often mimics malignancy clinically and radiologically.

Objective: The study was designed to explore the diagnostic value of superb microvascular imaging (SMI) in differentiating PCM from malignant breast lesions.

Methods: A total of 95 breast lesions underwent conventional ultrasound (US) and SMI examination between May 2016 and April 2018. Read More

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http://dx.doi.org/10.3233/CH-180468DOI Listing
January 2018
1 Read

Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome.

Clin Hemorheol Microcirc 2018 Dec 28. Epub 2018 Dec 28.

Department of Chemical and Materials Engineering, San José State University, San José, CA, USA.

Background: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are made worse by physical or mental exertion. While the etiology of the disease is still debated, evidence suggests oxidative damage to immune and hematological systems as one of the pathophysiological mechanisms of the disease. Read More

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http://dx.doi.org/10.3233/CH-180469DOI Listing
December 2018
17 Reads
2.242 Impact Factor

Influence of limited examination conditions on contrast-enhanced sonography for characterising liver lesions.

Clin Hemorheol Microcirc 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology and Interdisciplinary Ultrasound Department, University Hospital Regensburg, Regensburg, Germany.

Aim: To assess the influence of difficult examination conditions onto the diagnostic performance of CEUS (contrast-enhanced ultrasound) in focal liver lesions (FLL).

Methods: 77 liver CEUS examinations of 75 patients were analysed retrospectively. CEUS was performed as the first diagnostic procedure by one experienced sonographer after bolus injection of 1. Read More

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http://dx.doi.org/10.3233/CH-189417DOI Listing
December 2018
2 Reads

Recent advances in microfluidic platelet function assays: Moving microfluidics into clinical applications.

Clin Hemorheol Microcirc 2018 Dec 18. Epub 2018 Dec 18.

Department of Mechanical Engineering, Korea University, Seoul, Korea.

The analysis of platelet aggregation and thrombosis kinetics has significantly advanced with progress in microfluidic technology. However, the results of platelet aggregation tests do not fully reflect the observed clinical outcomes. To address the present unmet clinical needs, the basic but essential biology of platelets should be reconsidered in relation to the characteristics of microfluidic systems employed for platelet tests. Read More

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http://dx.doi.org/10.3233/CH-189416DOI Listing
December 2018
2 Reads
2.242 Impact Factor

Diagnostic performance of ultrasound strain elastography for differentiation of malignant breast lesions.

Clin Hemorheol Microcirc 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology, University Hospital Regensburg, Germany.

Objective: Objective of the study was to assess the performance of ultrasound strain elastography combined with conventional B-mode ultrasound to diagnose suspicious breast lesions (BI-RADS 4 and 5).

Methods: Between January 2015 and December 2017, a total of 86 patients (55±17.9 years) with solid or unclear, non-cystic breast lesions were enrolled in the study. Read More

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http://dx.doi.org/10.3233/CH-189415DOI Listing
December 2018
1 Read

Renal ischemia-reperfusion-induced metabolic and micro-rheological alterations and their modulation by remote organ ischemic preconditioning protocols in the rat.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet.

Objective: To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat.

Methods: In Control group the left femoral artery was cannulated and the left kidney was gently exposed. Read More

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http://dx.doi.org/10.3233/CH-189414DOI Listing
December 2018
2 Reads

Acute L-Arginine supplementation does not affect red blood cell aggregation and deformability during high intensity interval exercise in healthy men.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Department of Biological Sciences in Sport and Health, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.

Background: L-Arginine, the precursor of NO might be involved in improving the cardiovascular disorders via regulation of functional properties of erythrocytes.

Objective: This study investigated the effects of L-Arginine supplementation on responses of red blood cell (RBC) properties to high intensity interval exercise (HIIE).

Methods: Ten overweight healthy men participated voluntarily in the study and performed two HIIE trials with and without L-Arginine in two separate weeks. Read More

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http://dx.doi.org/10.3233/CH-189413DOI Listing
December 2018
1 Read

Shear-stress mediated nitric oxide production within red blood cells: A dose-response.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Menzies Health Institute, Griffith University, Gold Coast, Australia.

Background: Red blood cells (RBC) are exposed to varying shear stress while traversing the circulatory system; this shear initiates RBC-derived nitric oxide (NO) production.

Objective: The current study investigated the effect of varying shear stress dose on RBC-derived NO production.

Methods: Separated RBC were prepared with the molecular probe, diamino-fluoreoscein diacetate, for fluorometric detection of NO. Read More

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http://dx.doi.org/10.3233/CH-189412DOI Listing
December 2018
1 Read

Impact of intraoperative use of vasopressors in lower extremity reconstruction: Single centre analysis of 437 free gracilis muscle and fasciocutaneous anterolateral thigh flaps.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Centre of Plastic, Aesthetic, Hand and Reconstructive Surgery, University of Regensburg, Franz-Josef-Strauß-Allee, Regensburg, Germany.

Background: While complication rates in free tissue transfers have continuously decreased over time due to improved techniques, the intraoperative use of vasopressors and their negative effects on flap microcirculation and patency of the anastomoses remains controversial. To further elucidate this matter, this retrospective study examines the effect of intraoperative vasopressors on free gracilis muscle and free fasciocutaneous anterolateral thigh (ALT) flaps for lower extremity reconstruction.

Methods: A total of 425 patients underwent 437 free flaps for lower limb reconstruction. Read More

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http://dx.doi.org/10.3233/CH-189411DOI Listing
December 2018
1 Read

Shear-induced platelet adherence and activation in an in-vitro dynamic multiwell-plate system.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies Helmholtz-Zentrum Geesthacht, Teltow, Germany.

Circulating blood cells are prone to varying flow conditions when contacting cardiovascular devices. For a profound understanding of the complex interplay between the blood components/cells and cardiovascular implant surfaces, testing under varying shear conditions is required. Here, we study the influence of arterial and venous shear conditions on the in vitro evaluation of the thrombogenicity of polymer-based implant materials. Read More

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http://dx.doi.org/10.3233/CH-189410DOI Listing
December 2018
2 Reads

Contrast-enhanced ultrasound (CEUS) and gallbladder diseases - a retrospective mono-center analysis of imaging findings with histopathological correlation.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Marchioninistr, Munich, Germany.

Background: Radiologic imaging, especially ultrasound has an important role in the assessment of gallbladder alteration. Contrast-enhanced ultrasound (CEUS) is an easy and fast imaging technique that overcomes the limitations of greyscale ultrasonography. It is a safe tool that can be used as an additional imaging modality in order to elucidate and differentiate gallbladder pathological findings. Read More

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http://dx.doi.org/10.3233/CH-189405DOI Listing
December 2018
1 Read

Contrast-enhanced ultrasound (CEUS) for the evaluation of gallbladder diseases in comparison to cross-sectional imaging modalities and histopathological results.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Marchioninistr, Munich, Germany.

Background: The first method of choice for gallbladder alteration detection is the conventional ultrasound. Due to some imaging limitations, contrast-enhanced ultrasound (CEUS) has been widely used in the last years. CEUS is an additional modality that is able to depict microvessels flow and elucidate suspicious findings. Read More

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http://dx.doi.org/10.3233/CH-189404DOI Listing
December 2018
1 Read

Coronary microvascular disease and clinical prognosis in deferred lesions: The index of microcirculatory resistance.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Department of Internal Medicine, Division of Cardiology, Ulsan Medical Center, Ulsan Hospital, Ulsan, Republic of Korea.

While fractional flow reserve (FFR) is a good diagnostic index to assess the myocardial ischemia, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) can be used to address microvascular status without any significant epicardial disease. The independent predictors of for FFR and IMR are totally different and acts differently on the macro- and micro-vascular dysfunction. In high FFR patients, low CFR and high IMR which indicates the presence of overt microvascular disease demonstrated poor prognosis. Read More

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http://dx.doi.org/10.3233/CH-189403DOI Listing
December 2018
1 Read

Evaluation of Laser-Doppler-Fluxmetry for the diagnosis of microcirculatory disorders.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

University of Applied Sciences Fulda, Germany.

Background: The laser Doppler fluxmetry (LDF) is a non-invasive method to assess skin blood perfusion, measuring the flow of blood cells inside a tissue volume without harming the tissue. In the diagnosis of skin circulation disorders, the results of the LDF measurement are generally used in such a way that "normal" (or non-ill) or "pathological" values are achieved by comparison with a reference sample, for example of apparently healthy subjects.

Material And Methods: In this study, the values of LDF for the diagnosis of microcirculatory disorders in patients with coronary artery disease (n = 20) or in patients with microcirculatory disorders, already diagnosed by capillary microscopy (n = 46), were examined. Read More

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http://dx.doi.org/10.3233/CH-189402DOI Listing
December 2018
1 Read

Long-term outcome of open surgery in CVI patients concerning postoperative complications, perioperative hemodynamics and clinical efficacy, Part II.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Dermatological Clinic of the university of Greifswald, Germany.

Background: Chronic venous disease (CVD) is extremely common worldwide with prevalence increasing with age. It is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its, endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. Read More

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http://dx.doi.org/10.3233/CH-189401DOI Listing
December 2018
2 Reads

Percutaneous irreversible electroporation of hepatocellular carcinoma: Contrast-enhanced ultrasound-findings during 1-year follow-up.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Institute for Radiology, University Hospital Regensburg, Regensburg, Germany.

Purpose: To assess the postprocedure findings after percutaneous irreversible electroporation (IRE) of hepatocellular carcinoma (HCC) in contrast-enhanced ultrasound (CEUS).

Materials And Methods: Percutaneous IRE was performed in a total of 22 patients with 24 HCC tumours following interdisciplinary tumour board review. The lesions were documented using CEUS before, immediately and within 24 hours after IRE. Read More

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http://dx.doi.org/10.3233/CH-180449DOI Listing
December 2018
1 Read

Microvascular complications in orthokeratology (Ortho-K): A real-time study on the microvasculature of the bulbar conjunctiva in Ortho-K treatment.

Clin Hemorheol Microcirc 2018 Dec 12. Epub 2018 Dec 12.

Amazon Web Services, Seattle, WA, USA.

Orthokeratology (Ortho-K) is an over-night hard contact lens therapy, which physically reshapes the corneal curvature in order to stabilize or temporally eliminate myopia in patients. We hypothesize that the prolonged physical contact and mechanical pressure induced by the Ortho-K lenses may create lasting inadvertent effects and damages (microangiopathy), and may bring about unwanted changes in the microvasculature of the bulbar conjunctiva. Computer-assisted intravital microscopy (CAIM) was used to view, document (via videotaping) and objectively quantify (via computer-assisted image analysis) the real-time dynamic and morphometric characteristics of the conjunctival microcirculation in long-term (at least over one year) Ortho-K patients (n = 11) and matched non-user control subjects (n = 8). Read More

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http://dx.doi.org/10.3233/CH-189908DOI Listing
December 2018
1 Read

Laser Doppler-based measurements of periarticular blood flux can be utilized for assessment of arthritis pain: A hypothesis.

Clin Hemorheol Microcirc 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology, Dalhousie University Halifax, Canada.

Arthritis often presents with serious pain of the affected joints. The pain results mainly from underlying inflammatory processes initiated by the immune response to the degenerative structural changes within the joints and is associated with microvascular vasodilation that increases articular blood flow. Laser Doppler-based methods facilitate reliable quantification of microvascular perfusion. Read More

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http://dx.doi.org/10.3233/CH-189408DOI Listing
December 2018
1 Read

Comparison of PIRADS 3 lesions with histopathological findings after MRI-fusion targeted biopsy of the prostate in a real world-setting.

Clin Hemorheol Microcirc 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Radiology, Interdisciplinary Ultrasound-Center, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Introduction: We aimed to evaluate whether PIRADS 3 lesions in multiparametric MRI (mpMRI) represent a significant risk of prostate cancer (PCa) in a real-world setting of different referring radiologic institutes.

Materials And Methods: Between May 2015 and October 2017, a total of 408 patients were referred to our clinic for MRI-ultrasound fusion targeted biopsy of the prostate (FusPbx) due to suspected prostate cancer. In all patients, preoperatively an mpMRI of the prostate was performed by altogether 62 different radiologic institutes. Read More

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http://dx.doi.org/10.3233/CH-189407DOI Listing
December 2018
5 Reads

Papillary renal cell carcinoma in contrast-enhanced ultrasound (CEUS) - a diagnostic performance study.

Clin Hemorheol Microcirc 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, Ludwig-Maximilians-University Munich, Grosshadern Campus, Marchioninistr, Munich, Germany.

Background: Renal cell carcinomas (RCC) represent a heterogeneous group of hypo- and hypervascularized malignancies. Using contrast-enhanced ultrasound (CEUS) specific imaging features of clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC) subtypes have been demonstrated. However, some RCCs show atypical imaging features making it difficult to distinguish between the subtypes. Read More

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http://dx.doi.org/10.3233/CH-189406DOI Listing
December 2018
1 Read

Endothelial cell migration, adhesion and proliferation on different polymeric substrates.

Clin Hemorheol Microcirc 2018 Dec 8. Epub 2018 Dec 8.

Background: The formation of a functionally-confluent endothelial cell (EC) monolayer affords proliferation of EC, which only happens in case of appropriate migratory activity.

Aim Of The Study: The migratory pathway of human umbilical endothelial cells (HUVEC) was investigated on different polymeric substrates.

Material And Methods: Surface characterization of the polymers was performed by contact angle measurements and atomic force microscopy under wet conditions. Read More

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http://dx.doi.org/10.3233/CH-189317DOI Listing
December 2018
1 Read

Sonography of the renal allograft: Correlation between doppler sonographic resistance index (RI) and histopathology.

Clin Hemorheol Microcirc 2018 Dec 12. Epub 2018 Dec 12.

Abteilung für Nephrologie, Klinikum rechts der Isar der Technischen Universität München, Germany.

Introduction: Allograft rejection (AR), chronic allograft injury (CAI) and acute tubular necrosis (ATN) can lead to renal allograft dysfunction after kidney transplantation. Interstitial fibrosis/tubular atrophy (Banff classification 2005) describes chronic allograft injury with no specific etiology, thus explaining the common final endpoint of various (immunologic and non immunologic) etiologies. The aim of this study was to evaluate correlations between the Doppler sonographic RI-values and histopathological changes of renal allografts biopsies during rejection, acute tubular necrosis and chronic allograft injury as well as the influence of donor and recipient features on the intrarenal RI-values. Read More

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http://dx.doi.org/10.3233/CH-189306DOI Listing
December 2018
2 Reads

Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

Clin Hemorheol Microcirc 2018 Dec 3. Epub 2018 Dec 3.

Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.

Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis and immune modulatory function. Further, they can differentiate into smooth muscle cells or endothelial-like cells and secret pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Read More

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http://dx.doi.org/10.3233/CH-189418DOI Listing
December 2018
1 Read

The relationship between the rheological behavior of RBCs and angiogenesis in the morbidly obese.

Clin Hemorheol Microcirc 2018 Dec 3. Epub 2018 Dec 3.

Department of General and Bariatric Surgery and Emergency Medicine in Zabrze, Medical University of Silesia in Katowice, Poland.

Objective: The aim of this study was to investigate the relationship between red blood cell (RBC) aggregation and deformability and angiogenesis parameters in obese patients.

Methods: We studied 35 obese subjects and 20 non-obese people as a control group. Angiogenesis was detected using Bio-Plex Pro Human Angiogenesis Multiplex Assays. Read More

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http://dx.doi.org/10.3233/CH-180420DOI Listing
December 2018
1 Read

Characterization of thoracal fat depots - expression of adipokines and remodeling factors and impact of adipocyte conditioned media in fibroblast scratch assays.

Clin Hemorheol Microcirc 2018 ;70(3):267-280

Department of Cardiac Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Herzzentrum Dresden, Germany.

Adipose tissue is not only a connective tissue but also an endocrine organ secreting adipokines like Leptin and Adiponectin, lipokines such as palmitoileic acid and extracellular vesicles. These factors and the expression of matrix remodeling enzymes impact surrounding tissues via paracrine effects. The expression of selected secretion factors and the effect of adipocyte conditioned media from four thoracal adipose tissue origins - subcutaneous, perivascular, pericardial and epicardial adipose tissues - in a fibroblast proliferation/wound healing scratch assay model were investigated. Read More

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http://dx.doi.org/10.3233/CH-170341DOI Listing
January 2019
1 Read

Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia1,2.

Clin Hemorheol Microcirc 2018 Nov 29. Epub 2018 Nov 29.

Department of Anaesthesiology and Intensive Care, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.

Background: Damage of the endothelial glycocalyx (EG) has been described during surgery, but the effect of different anesthesia techniques remains unknown. Perfused boundary region (PBR) evaluated by side-stream dark field (SDF) imaging of the sublingual microcirculation enables in vivo EG assessment. PBR values are inversely related to the EG thickness. Read More

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http://dx.doi.org/10.3233/CH-180428DOI Listing
November 2018
13 Reads

Terminologies regarding sickle cell retinopathy.

Clin Hemorheol Microcirc 2018 Nov 13. Epub 2018 Nov 13.

Bahiana's School of Medicine and Public Health, Salvador, Brazil.

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http://dx.doi.org/10.3233/CH-180462DOI Listing
November 2018
2 Reads
2.242 Impact Factor

Predicting cervical lymph node metastasis in patients with papillary thyroid cancer (PTC) - Why contrast-enhanced ultrasound (CEUS) was performed before thyroidectomy.

Clin Hemorheol Microcirc 2018 Nov 15. Epub 2018 Nov 15.

The objective of this research was to investigate the clinical value of contrast-enhanced ultrasound (CEUS) for prediction of cervical lymph node metastasis (CLNM) in papillary thyroid cancer (PTC).One hundred and eighty-six patients with PTC confirmed by fine needle aspiration (FNA) were preoperatively performed CEUS.A multivariate analysis was performed to predict CLNM by 15 independent variables. Read More

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http://dx.doi.org/10.3233/CH-180454DOI Listing
November 2018
8 Reads

Use of RBC deformability index as an early marker of diabetic nephropathy.

Clin Hemorheol Microcirc 2018 Nov 15. Epub 2018 Nov 15.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Background And Objective: Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN).

Methods: 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Read More

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http://dx.doi.org/10.3233/CH-180434DOI Listing
November 2018
15 Reads
2.242 Impact Factor

Prolonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in rats.

Clin Hemorheol Microcirc 2018 Nov 13. Epub 2018 Nov 13.

Cardiff School of Health Sciences, Cardiff Metropolitan University, Western Avenue, Cardiff, UK.

Background: Exposure to air pollution is associated with cardiovascular disease, including increased morbidity and mortality rates.

Objective: The aim of this investigation was to assess the effect, in rats, of intratracheal instillation of particulate air pollution on biomarkers of leucocyte activation and vascular endothelial damage.

Methods: Air pollution particles (PM10) were instilled into rats, and blood samples were taken three days and six weeks post instillation. Read More

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http://dx.doi.org/10.3233/CH-180377DOI Listing
November 2018
8 Reads

Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits.

Clin Hemorheol Microcirc 2018 Nov 2. Epub 2018 Nov 2.

Department of Anaesthesiology and Intensive Care Medicine, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Czech Republic.

Background And Objective: The endothelial glycocalyx (EG) is fragile and sensitive to damage such as exposure to hypernatremia. Our aim was to describe the influence of hypernatremia on the EG in sublingual and brain microcirculation in rabbits.

Methods: Hypernatremia was induced by intravenous administration of 10% NaCl solution. Read More

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http://dx.doi.org/10.3233/CH-189907DOI Listing
November 2018
18 Reads

Human and equine endothelial cells in a life cell imaging scratch assay in vitro.

Clin Hemorheol Microcirc 2018 Oct 29. Epub 2018 Oct 29.

Freie Universität Berlin, Department of Veterinary Medicine, Institute for Veterinary Anatomy, Germany.

Background: Human and equine patients are known to frequently develop vascular complications, particularly thrombosis both in veins and arteries as well as in the microvasculature.

Objective: The aim of the present study was to investigate and compare the angiogenic response of human and equine endothelial cells to lesions in an in vitro scratch assay.

Methods: Endothelial cells from human umbilical vein (HUVEC), abdominal aorta (HAAEC) and dermal microvasculature (HDMEC) as well as equine carotid artery (EACEC) and jugular vein (EVJEC) were cultured and an elongated defect was created (scratch or "wound"). Read More

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http://dx.doi.org/10.3233/CH-189316DOI Listing
October 2018
17 Reads

First experience of chick chorioallantoic membrane (CAM) assay in the clinical work flow with oral squamous cell carcinoma patients.

Clin Hemorheol Microcirc 2018 Oct 29. Epub 2018 Oct 29.

Center of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.

Introduction: The oral squamous cell carcinoma (OSCC) is a leading cause of death in human malignancies. The aim of this study is to integrate the CAM Assay as a reliable and good working in vivo model for the evaluation of OSCC tumor samples and its growth into the clinical work flow.

Material And Methods: Fresh human Tumor samples (OSCCs) 1×1 cm in size were cut into 350-450μm thick slices by a Vibratome and put on the prepared CAM model. Read More

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http://dx.doi.org/10.3233/CH-189315DOI Listing
October 2018
11 Reads

Efficacy of dynamic enhancement effects on Gd-EOB-DTPA-enhanced MRI for estimation of liver function assessed by 13C- Methacetin breath test.

Clin Hemorheol Microcirc 2018 Oct 22. Epub 2018 Oct 22.

Department of Radiology, University Hospital Regensburg, Regensburg, Germany.

Purpose: Contrast enhanced magnetic resonance imaging (MRI) is able to assess liver function by characteristic changes of signal intensity (SI).The aim was to evaluate dynamic contrast-enhanced SI-indices of the abdominal aorta, portal vein and liver.

Methods: 72 patients underwent Gd-EOB-DTPA-enhanced MRI and a 13C-methacetin-based liver breath test (13C-MBT) for evaluation of liver function. Read More

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http://dx.doi.org/10.3233/CH-189324DOI Listing
October 2018
1 Read

Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts.

Clin Hemorheol Microcirc 2018 Oct 20. Epub 2018 Oct 20.

Polycarbonate (PC) substrate is well suited for culturing human mesenchymal stem cells (MSCs) with high proliferation rate, low cell apoptosis rate and negligible cytotoxic effects. However, little is known about the influence of PC on MSC activity including senescence, differentiation and secretion. In this study, the PC cell culture insert was applied for human MSC culture and was compared with polystyrene (PS) and standard tissue culture plate (TCP). Read More

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http://dx.doi.org/10.3233/CH-189322DOI Listing
October 2018
10 Reads

Proof of principle: Estimation of liver function using color coded Doppler sonography of the portal vein.

Clin Hemorheol Microcirc 2018 Oct 19. Epub 2018 Oct 19.

Department of Radiology, University Hospital Regensburg, Regensburg, Germany.

Background: The diagnostic value of Doppler ultrasonography of the portal vein for the evaluation of liver function is still contradictory.

Objective: Aim of this study was to test the relationship between clinical liver function tests based on MRI and breath testing and blood flow in the portal vein.

Methods: The portal vein velocity was measured by color coded Doppler ultrasonography (CCDS) and tested against the relative enhancement (RE), a MRI-based index of liver function. Read More

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http://dx.doi.org/10.3233/CH-189323DOI Listing
October 2018
9 Reads

Optimized protocol for induction of cytochrome P450 enzymes 1A2 and 3A4 in human primary-like hepatocyte cell strain HepaFH3 to study in vitro toxicology.

Clin Hemorheol Microcirc 2018 Oct 19. Epub 2018 Oct 19.

Background: Drug induced liver injury (DILI) is the most frequent cause for failure of new drugs in clinical studies. Thus, toxicity studies are indispensable during drug development. The proliferative human liver cell strain HepaFH3 with promising primary-like cellular properties might be a suitable liver model for such studies, but their cytochrome-P450 (CYP) expression is still in low ranges compared to freshly isolated primary human hepatocytes. Read More

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http://dx.doi.org/10.3233/CH-189321DOI Listing
October 2018
12 Reads

Inhibition of GPR 55 improves dysregulated immune response in experimental sepsis.

Clin Hemorheol Microcirc 2018 Oct 19. Epub 2018 Oct 19.

Sepsis is a medical condition caused by dysregulated systemic inflammatory response against infection, resulting in high mortality. Despite intensive research over the last few decades, the results from multiple clinical trials targeting specific inflammatory mediators have been disappointing. In the present study, we investigated the role of G protein-coupled receptor GPR55 modulation on immune response in an experimental sepsis model (endotoxemia). Read More

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http://dx.doi.org/10.3233/CH-189320DOI Listing
October 2018
1 Read

PDGF regulated migration of mesenchymal stem cells towards malignancy acts via the PI3K signaling pathway.

Clin Hemorheol Microcirc 2018 Oct 19. Epub 2018 Oct 19.

Applied Stem Cell Research Center, University Medical Center Regensburg, Germany.

Introduction: Mesenchymal stem cells (MSCs) have been described in breast cancer models to migrate towards carcinoma and integrate into tumor associated stroma supporting tumor growth, increasing their metastatic potency and contributing to tumor-angiogenesis. Platelet-derived growth factor (PDGF) isoforms (AA, BB, CC) stimulate growth, survival and motility of MSCs and certain other cell types. Noteworthy, breast carcinomas are known to express PDGF. Read More

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http://dx.doi.org/10.3233/CH-189319DOI Listing
October 2018
15 Reads
2.242 Impact Factor

Enhancement of human induced pluripotent stem cells adhesion through multilayer laminin coating.

Clin Hemorheol Microcirc 2018 Oct 17. Epub 2018 Oct 17.

Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße, Teltow, Germany.

Bioengineered cell substrates are a highly promising tool to govern the differentiation of stem cells in vitro and to modulate the cellular behavior in vivo. While this technology works fine for adult stem cells, the cultivation of human induced pluripotent stem cells (hiPSCs) is challenging as these cells typically show poor attachment on the bioengineered substrates, which among other effects causes substantial cell death. Thus, very limited types of surfaces have been demonstrated suitable for hiPSC cultures. Read More

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http://dx.doi.org/10.3233/CH-189318DOI Listing
October 2018
11 Reads

Blood parameter analysis after short term exposure to weightlessness in parabolic flight.

Clin Hemorheol Microcirc 2018 Oct 17. Epub 2018 Oct 17.

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Germany.

Background: Parabolic flights offer a unique platform for human experiments in short-term weightlessness. It is generally known that human organ systems react to changes of gravity. Yet, little is known about alterations of blood parameters under these conditions with special emphasis on blood rheology. Read More

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http://dx.doi.org/10.3233/CH-189314DOI Listing
October 2018
2 Reads