Search our Database of Scientific Publications and Authors

I’m looking for a

    2219 results match your criteria Clinical Hemorheology and Microcirculation [Journal]

    1 OF 45

    Early sign of microangiopathy in systemic sclerosis: The significance of cold stress test in dynamic laser Doppler flowmetry.
    Clin Hemorheol Microcirc 2018 Jun 5. Epub 2018 Jun 5.
    Department of Dermatology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be normal during early stage of microangiopathy in SSc. Read More

    Bridging the gap between basic research on microcirculation and clinical world: The translational marriage between engineering and medicine.
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Department of Industrial Engineering, University of Padova Padova, Italy.
    The words "Translational" and "Medicine" have been recently coupled to indicate a combination of disciplines, resources, expertise, and techniques aimed at enhancing prevention, diagnosis, and therapies. As stated in 2015 by the European Society for Translational Medicine, translational medicine is "an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community". By definition, Translational Medicine is a highly interdisciplinary field, which gathers several specialties aimed at improving the global healthcare system. Read More

    The effects of venous hemodynamics on angiogenesis in morbid obese.
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
    Background: It is known that obesity is associated with alterations in blood rheology and venous hemodynamics. Another recent study has confirmed that adipose tissue is actively involved in angiogenesis through secretion of biologically active substances.

    Objective: The aim of this study was to investigate the impact on the venous haemodynamics of the femoral vein on angiogenesis status in morbidly obese patients. Read More

    Proliferative retinopathy and maculopathy are two independent conditions in sickle cell disease: Is there a role of blood rheology?1.
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Université des Antilles, CHU dePointe-à-Pitre, Guadeloupe, Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge UMR_S1134, Paris, France.
    Objective: Our study investigated the prevalence of retinopathy and maculopathy in sickle cell patients and tested the association between these two conditions. In addition, we tested whether hematological and hemorheological parameters, as well as genotype, were involved in the development of these two conditions.

    Methods: Seventy sickle cell adult patients were recruited: 37 with sickle cell anemia (SCA) and 33 with sickle cell hemoglobin C disease (SCC). Read More

    Three-dimensional shear wave elastography for differentiation of breast lesions: An initial study with quantitative analysis using three orthogonal planes.
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Objectives: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes.

    Methods: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE. Read More

    Differentiation of malignant liver tumors by software-based perfusion quantification with dynamic contrast-enhanced ultrasound (DCEUS).
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Department of Internal Medicine 1, University Hospital Erlangen, Friedrich-Alexander-UniversityErlangen-Nuremberg, Erlangen, Germany.
    BACKGROUNDEnhancement patterns on contrast-enhanced ultrasound (CEUS) help to distinguish different liver tumors.

    Objective: Assessing the diagnostic value of dynamic contrast-enhanced ultrasound (DCEUS) for the discrimination of different malignant liver lesions.

    Methods: 148 malignant focal liver lesions were assessed prospectively with DCEUS (hepatocellular carcinoma = HCC; cholangiocellular carcinoma = CCC; pancreatic adenocarcinoma = PCA; breast cancer = BC; colorectal cancer = CRC; melanoma = MM). Read More

    The expression of hSR-B1 receptor on platelets of patients with coronary artery disease (CAD).
    Clin Hemorheol Microcirc 2018 May 25. Epub 2018 May 25.
    Departmentof Herbal Medicine, Pars Biosciences Research Center, Kansa, USA.
    Introduction: The human scavenger receptor class B type 1 (hSR-B1), which serves as a high affinity receptor for HDL, is expressed on platelet surface and mediates various anti-atherogenic functions. Based on the anti-thrombotic effects of HDL and the importance of HDL-SR-B1 in the formation of atherosclerotic plaque, the present study was aimed to investigate and compare the expression level of hSR-B1on platelets of CAD patients with that of normal controls.

    Methods: The expressions of the hSR-B1 on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls were detected using flowcytometry and western blotting. Read More

    Comparison of two substrate materials used as negative control in endothelialisation studies: Glass versus polymeric tissue culture plate.
    Clin Hemorheol Microcirc 2018 May 21. Epub 2018 May 21.
    Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
    The endothelialisation of synthetic surfaces applied as cardiovascular implant materials is an important issue to ensure the anti-thrombotic quality of a biomaterial. However, the rapid and constant development of a functionally-confluent endothelial cell monolayer is challenging. In order to investigate the compatibility of potential implant materials with endothelial cells several in vitro studies are performed. Read More

    The efficacy of added shear wave elastography (SWE) in breast screening for women with inconsistent mammography and conventional ultrasounds(US).
    Clin Hemorheol Microcirc 2018 May 19. Epub 2018 May 19.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Purpose: To evaluate the efficacy of added shear wave elastography (SWE) in breast screening for women with results inconsistent between mammography and conventional ultrasounds (US).

    Materials And Methods: The study consisted of 282 pathologically proven breast lesions. The cancer probability from screening by mammography and conventional US were scored using Breast Imaging Reporting and Data System (BI-RADS). Read More

    Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study.
    Clin Hemorheol Microcirc 2018 May 19. Epub 2018 May 19.
    Kings College Hospital NHS Foundation Trust, London, UK.
    Background: Preclinical studies report that higher plasma viscosity improves microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical study has tested this hypothesis.

    Objective: We investigated the relationship between plasma viscosity and sublingual microcirculatory flow in patients during resuscitation for traumatic haemorrhagic shock (THS).

    Methods: Sublingual video-microscopy was performed for 20 trauma patients with THS as soon as feasible in hospital, and then at 24 h and 48 h. Read More

    Preinterventional hydrocortisone sustains the endothelial glycocalyx in cardiac surgery.
    Clin Hemorheol Microcirc 2018 May 19. Epub 2018 May 19.
    Department of Anaesthesiology and Intensive Care Medicine, Klinikum Fürstenfeldbruck, Fürstenfeldbruck, Germany.
    Background: Patients undergoing cardiac surgery commonly develop systemic inflammation associated with tissue edema, which impairs outcome. One main pathomechanism leading to the edema is the deterioration of the endothelial glycocalyx, a key component of the vascular barrier. In animal models hydrocortisone has proved to be protective for the glycocalyx. Read More

    Acoustic radiation force impulse elastography in evaluation of triple-negative breast cancer: A preliminary experience.
    Clin Hemorheol Microcirc 2018 May 19. Epub 2018 May 19.
    Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Purpose: To assess the elastographic features of triple-negative breast cancers and evaluate the diagnostic value of acoustic radiation force impulse imaging (ARFI) for the characterization of triple-negative breast cancers.

    Materials And Methods: This study analyzed data from 234 women with breast cancer. Patients were categorized into three groups; 1) triple-negative breast cancers (n = 48); 2) ER-positive tumors (n = 128) and 3) HER2-positive tumors (n = 58). Read More

    The controversial origin of pericytes during angiogenesis - Implications for cell-based therapeutic angiogenesis and cell-based therapies.
    Clin Hemorheol Microcirc 2018 ;69(1-2):215-232
    Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences, Wädenswil, Switzerland.
    Pericytes reside within the basement membrane of small vessels and are often in direct cellular contact with endothelial cells, fulfilling important functions during blood vessel formation and homeostasis. Recently, these pericytes have been also identified as mesenchymal stem cells. Mesenchymal stem cells, and especially their specialized subpopulation of pericytes, represent promising candidates for therapeutic angiogenesis applications, and have already been widely applied in pre-clinical and clinical trials. Read More

    Evaluation of integrated color-coded perfusion analysis for contrast-enhanced ultrasound (CEUS) after percutaneous interventions for malignant liver lesions: First results.
    Clin Hemorheol Microcirc 2018 ;69(1-2):59-67
    Institute of Radiology, University Hospital Regensburg, Regensburg, Germany.
    Background:  With the rising number of percutaneous ablation therapies in malignant liver lesions there is a need of reliable diagnostics after the intervention to differentiate between reactive changes and tumor.

    Purpose: To assess the success of percutaneous ablation therapies for malignant liver lesions using CEUS with perfusion analysis.

    Material And Methods: Retrospective analysis of perfusion analysis for 67 patients with 94 malignant liver lesions, treated with ablation therapies. Read More

    Blood urea nitrogen (BUN) independently predicts mortality in critically ill patients admitted to ICU: A multicenter study.
    Clin Hemorheol Microcirc 2018 ;69(1-2):123-131
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Germany.
    Background And Purpose: The Microcirculatory Shock Occurrence in Acutely Ill Patients (micro-SOAP) study investigated associations of microcirculation and mortality. Risk stratification in critically ill patients is of utmost interest. Established score such as APACHE2 (Acute Physiology And Chronic Health Evaluation 2) are relatively complex and might therefore be of limited use. Read More

    Adipose tissue-derived stem cells from affected and unaffected areas in patients with multiple symmetric lipomatosis show differential regulation of mTOR pathway genes.
    Clin Hemorheol Microcirc 2018 ;69(1-2):141-151
    Department of Plastic-, Hand-, and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
    Background: Multiple symmetric lipomatosis is a rare disease characterized by the excessive growth of uncapsulated masses of adipose tissue. Although the etiology has yet to be elucidated, a connection to brown adipose tissue has been proposed recently. The mTOR pathway which is found to be regulated in lipomatous tissue as well as associated with brown adipose tissue can be inhibited by a compound called rapamycin. Read More

    Magnetocardiography for the diagnosis of non-obstructive coronary artery disease1.
    Clin Hemorheol Microcirc 2018 ;69(1-2):9-11
    Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Anam-dong, Sungbuk-ku, Seoul, Republic of Korea.
    Ischemic heart disease (IHD) remains a major public health burden worldwide. It is estimated that one third of adults in the United States has some form of IHD, including more than 17 million with coronary artery disease (CAD) and nearly 10 million with angina pectoris [1]. Nevertheless, the detection of myocardial ischemia in patients with presumed CAD remains a challenge in contemporary practice. Read More

    Blood rheology during normal pregnancy.
    Clin Hemorheol Microcirc 2018 ;69(1-2):101-114
    Department of Obstetrics and Gynecology, City Hospital of Aschaffenburg, Aschaffenburg, Germany.
    Introduction: Recent studies have shown increased RBC aggregation and no difference in plasma viscosity in the presence of markedly lower hematocrit in women at term compared to non-pregnant women. Little is known about the outcome of blood rheological parameters and red blood cell (RBC) deformability particularly in the course of normal pregnancy.

    Methods: During a 36 months interval 1. Read More

    The wavelet analysis for the assessment of microvascular function with the laser Doppler fluxmetry over the last 20 years. Looking for hidden informations.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Industrial Engineering, Università di Padova, Italy.
    The wavelet analysis has been applied to the Laser Doppler Fluxmetry for assessing the frequency spectrum of the flowmotion to study the microvascular function waves.Although the application of wavelet analysis has allowed a detailed evaluation of the microvascular function, its use does not seem to be yet widespread over the last two decades.Aiming to improve the diffusion of this methodology, we herein present a systematic review of the literature about the application of the wavelet analysis to the laser Doppler fluxmetry signal. Read More

    Erythrocyte deformability and eryptosis during inflammation, and impaired blood rheology.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, South Africa.
    Objective: This review focusses on the erythrocytes (RBCs) and their structural changes during inflammation and impaired blood rheology. We discuss systemic inflammation and the effects of dysregulated inflammatory molecules. These pro-inflammatory molecules directly affect the haematological system, and particularly the RBCs, platelets and plasma proteins. Read More

    Viscoelasticity and structure of blood clots generated in-vitro by rheometry: A comparison between human, horse, rat, and camel.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Biomedical Research, Decentralized Biomedical Facilities, Medical University of Vienna, Austria.
    Background: Although the coagulation system is evolutionary well preserved, profound species differences exist in viscoelastic as well as in common laboratory tests of coagulation.

    Objective: Evaluating differences in clot formation and material characterisation of clots of four mammalian species on macro-, micro- and nanoscales by the means of rheometry, scanning electron microscopy (SEM) and small angle x-ray scattering (SAXS).

    Methods: Blood samples were collected from healthy human volunteers, laboratory rats (HL/LE inbred strain), warmblood horses and dromedary camels. Read More

    Deformability of different red blood cell populations and viscosity of differently trained young men in response to intensive and moderate running.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Molecular and Cellular Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, Germany.
    Background: Red blood cell (RBC) deformability and blood viscosity are essential to ensure optimal microcirculation and may contribute to athletic performance.

    Objective: To investigate the acute responses of density fractionated young, middle old and old RBC, RBC viscosity (RBCV), plasma viscosity (PV) and hematological changes to two running modes (intensive and moderate).

    Methods: 27 young and healthy men of different training status participated in this study and were grouped into three groups in accordance to their VO2peak and conducted an intensive and moderate running test, respectively (crossover design). Read More

    Seeking the optimal hematocrit: May hemorheological modelling provide a solution ?
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    U1046 INSERM, UMR 9214 CNRS «Physiopathologie and Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP», Unité d'Explorations Métaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France.
    Hematocrit increases during exercise and is usually decreased after regular training. However the interpretation of these facts is ambiguous since hematocrit is both a determinant of oxygen supply and the major determinant of blood viscosity. Classically hematocrit was assumed to impair blood flow, but it has been evidenced to exert a biphasic effect on it. Read More

    Two-dimensional shear wave elastography for differential diagnosis between mastitis and breast malignancy.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
    Objective: To determine the diagnostic performance of conventional ultrasound (US) and two-dimensional shear wave elastography (2D SWE) in the differential diagnosis between mastitis and breast malignancy.

    Methods: Between January 2016 and March 2017, 105 patients with 105 pathologically proven breast lesions were enrolled. All the lesions were subject to conventional US and 2D SWE examinations. Read More

    Beta-estradiol and ethinylestradiol enhance RBC deformability dependent on their blood concentration.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Institute of Molecular Medicine, Institute of Biochemistry, Faculty of Medicine, University of Lisbon, Portugal.
    Background: Natural and synthetic estrogens seems to have opposite effects on thrombosis and female cardiovascular system, since natural estrogen was supposed to be protective against cardiovascular diseases and synthetic estrogen has been related to thrombosis and cardiovascular diseases. In this work we have investigated if these differences could be related with the effects on those hormones on some hemorheological parameters.

    Objective: The objective of this work was to investigate the hemorheological changes of different concentrations of beta-estradiol and ethinylestradiol, on RBC aggregation and RBC deformability. Read More

    The combined effects of the microcirculatory status and cardiopulmonary bypass on platelet count and function during cardiac surgery.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
    Background: Cardiac surgery with cardiopulmonary bypass is associated with important changes in the microcirculation, usually attributed to endothelial dysfunction. Another common finding of cardiac surgery is postoperative thrombocytopenia and platelet loss of function.

    Objective: To investigate the association between microvascular flow pattern and postoperative changes in platelet count and function in cardiac surgery patients. Read More

    Pulmonary hemodynamic effects and pulmonary arterial compliance during hypovolemic shock and reinfusion with human relaxin-2 (serelaxin) treatment in a sheep model.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Institute for Biochemistry II, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
    Background: Previous studies on the recombinant form of human relaxin-2 (serelaxin) have shown a decrease of pulmonary hemodynamics after serelaxin injection. Currently, the effect of serelaxin treatment during hypovolemia in a large animal model remains mostly unknown.

    Methods: 12 sheep were randomly assigned to a sham or serelaxin (30μg/kg serelaxin) group and underwent right heart catheterization. Read More

    Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Shanghai Putuo District Central Hospital, Shanghai, China.
    Background: Breast cancer is the most common cancer in women worldwide. The purpose of the study was to observe the features of contrast-enhanced ultrasound (CEUS) and the combination with Breast Imaging-Reporting and Data System (BI-RADS) of conventional ultrasound for assessing small breast lesions.

    Objectives: The study was to explore the small breast lesions' features of contrast-enhanced ultrasound (CEUS) and the combination with Breast Imaging-Reporting and Data System (BI-RADS) of conventional ultrasound, in order to improve the diagnostic accuracy of early breast cancer. Read More

    Analysis of human microcirculation in weightlessness: Study protocol and pre-study experiments.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Internal Medicine, Division of Cardiology, Pulmonary Diseases, Vascular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.
    Background: In weightlessness, alterations in organ systems have been reported. The microcirculation consists of a network of blood vessels with diameters of a few μm. It is considered the largest part of the circulatory system of the human body and essential for exchange of gas, nutrients and waste products. Read More

    Capsular fibrosis in aesthetic and reconstructive-cancer patients: A retrospective analysis of 319 cases.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University Hospital Regensburg, Germany.
    Background: Implant-based breast augmentation is one of the most frequently performed operations in plastic surgery worldwide, for aesthetic and reconstructive reasons. Capsular fibrosis is the most common long-term foreign body response after breast implant augmentation.

    Objective: To compare the occurrence of capsular contracture in aesthetic and reconstructive-cancer patients, including those patients who received radiotherapy prior to breast reconstruction with implants. Read More

    Beneficial effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in the rat.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Background: Remote ischemic preconditioning (RIPC) can be protective against the damage. However, there is no consensus on the optimal amount of tissue, the number and duration of the ischemic cycles, and the timing of the preconditioning. The hemorheological background of the process is also unknown. Read More

    The utility and limitations of contrast-enhanced transrectal ultrasound scanning for the detection of prostate cancer in different area of prostate.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Objective: To evaluate the ability of contrast-enhanced transrectal ultrasound (CETRUS) scanning for prostate cancer detection in different area, compared with conventional transrectal ultrasound (TRUS).

    Methods: 228 patients underwent TRUS-guided prostate biopsy after examinations of TRUS and CETRUS scanning. Cancer detection between CETRUS and TRUS were compared by patient and by site in different areas (right, left; base, mid-gland, apex). Read More

    Aging decreases CO2 reactivity in the retinal artery, but not in the ocular choroidal vessels; a cross-sectional study.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Tokyo, Japan.
    Background: The CO2 reactivity is often used to assess vascular function, but it is still unclear whether this reactivity is affected by aging.

    Objective: To investigate the effects of aging on the CO2 reactivity in ocular and cerebral vessels, both of which are highly sensitive to hypercapnia, we compared the CO2 reactivity in the retinal artery (RA), retinal and choroidal vessels (RCV), optic nerve head (ONH), and middle cerebral artery (MCA) between young and middle-aged subjects.

    Methods: We measured the CO2 reactivity in 14 young and 11 middle-aged males using laser-speckle flowgraphy during a 3-min inhalation of CO2-rich air. Read More

    Comparative evaluation of Plateletworks, Multiplate analyzer and Platelet function analyzer-200 in cardiology patients.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
    The objective of this study was to comparatively evaluate three commercial whole-blood platelet function analyzer systems: Platelet Function Analyzer-200 (PFA; Siemens Canada, Mississauga, Ontario, Canada), Multiplate analyzer (MP; Roche Diagnostics International Ltd., Rotkreuz, Switzerland), and Plateletworks Combo-25 kit (PLW; Helena Laboratories, Beaumont, TX, USA). Venipuncture was performed on 160 patients who visited a department of cardiology. Read More

    Effects of ex vivo aging and storage temperature on blood viscosity.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Center for Molecular and Engineering Thermodynamics and Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.
    Background: Research on hemorheology is driven in part by its significance in blood diseases and the possible use of hemorheology as a diagnostic tool. However, existing data on blood rheology are limited largely to measurements of steady shear behavior often with varying measurement protocols and insufficient characterization of the physiology.

    Objective: The effects of ex vivo aging and environmental conditions on blood viscosity are investigated to improve standards for hemorheology measurements. Read More

    Eryptosis in Haemochromatosis: Implications for rheology.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Physiological Sciences, Stellenbosch University, South Africa.
    Background: Haemochromatosis is an iron-storage disease with different genetic mutations, characterized by an increased intestinal absorption of iron, resulting in a deposition of excessive amounts of iron in parenchymal cells. When the iron is released in the blood, it is left in an unliganded form, where it can participate in Haber-Weiss and Fenton reactions, creating hydroxyl radicals. Erythrocytes (RBCs) are particularly vulnerable to hydroxyl radical damage, which can result in eryptosis (programmed cell death similar to apoptosis). Read More

    Effects of polymer-coated boron nitrides with increased hemorheological compatibility on human erythrocytes and blood coagulation.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Background: Boron nitride (BN) nanomaterials are promising in biomedical research owing to their large surface area, graphene-like structure, and chemical and thermal properties. However, the toxicological effects of BN on erythrocytes and blood coagulation remain uninvestigated.

    Objective: The aims of our study were to synthesize glycol chitosan (GC)- and hyaluronic acid (HA)-coated BNs, and to investigate the effects of these BNs on human cancer cells, erythrocytes, and whole blood. Read More

    Diagnostic value of coustic radiation force impulse for BI-RADS category 4 breast lesions of different sizes.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
    Objective: To determine the diagnostic value of combined conventional ultrasound (US) and acoustic radiation force impulse (ARFI) imaging for the differential diagnosis of BI-RADS category 4 breast lesions of different sizes.

    Materials And Methods: From April 2013 to January 2015, 283 patients (with a total of 292 breast lesions) who underwent US and ARFI examination were included in this retrospective study. The SWV for the lesion and adjacent normal breast tissue were measured and the SWV ratio was calculated. Read More

    Approaches to improve the predictive value of laser Doppler flowmetry in detection of microcirculation disorders in diabetes mellitus.
    Clin Hemorheol Microcirc 2018 Apr 14. Epub 2018 Apr 14.
    Moscow Regional Research and Clinical Institute, Moscow, Russia.
    Background: Laser Doppler flowmetry is widely used in scientific studies of blood microcirculation but constrained in clinical use due to the low diagnostic significance.

    Objective: This research is aimed at creation of approaches to prognostic value increase in detection of microcirculation disorders in patients with type 2 diabetes mellitus.

    Methods: The study included 10 volunteers and 10 patients with t2DM. Read More

    Ecchymosis: A novel sign in patients with varicose veins.
    Clin Hemorheol Microcirc 2018 ;68(4):413-419
    Department of Cardiovascular Medicine, Division of Cardiology, Munster University Hospital, Munster, Germany.
    Background: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. Read More

    Adrenal schwannoma: CT, MR manifestations and pathological correlation.
    Clin Hemorheol Microcirc 2018 ;68(4):401-412
    Department of Radiology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
    Objectives: This study aimed to describe the computed tomography (CT), magnetic resonance imaging (MRI) imaging features of adrenal schwannoma and to correlate imaging findings with histopathologic findings.

    Methods: The findings from multiphase CT or MRI examinations of seventeen patients with histopathologically confirmed adrenal schwannoma were reviewed. The imaging criteria included shape, size, margin, attenuation, signal intensity, secondary degeneration, and internal mass enhancement pattern. Read More

    An explanation of the reversal of erythrocyte echinocytosis by incubation and storage by serum albumin.
    Clin Hemorheol Microcirc 2018 ;68(4):383-389
    Laboratoire de Chimie des Protéines, Montréal, QC, Canada.
    It is proposed that the specific reversal by serum albumin of the erythrocyte echinocytosis in an inorganic phosphate buffer saline or in a saline, either after 24 h in blood or after a storage of 6-7 weeks in SGAM or PAGGSM media, is due to a cell dehydration by a decrease of the total NaCl and KCl concentrations favoring the stomatocytogenic slow outward transport of inorganic phosphate with a hydrogen ion by band 3 anion exchanger, which was previously proposed to control the erythrocyte shape. This proposal would indicate that the opposition of the erythrocyte echinocytosis by serum albumin is not limited to binding to echinocytogenic amphiphiles, supported by the ability of the band 3-based mechanism of control of the erythrocyte shape to explain a variety of observations on the erythrocyte shape. It would also imply that this mechanism is a determinant of the erythrocyte rheological properties since influenced by cell shape and volume. Read More

    Abnormal rheological properties of red blood cells as a potential marker of Gulf War Illness: A preliminary study.
    Clin Hemorheol Microcirc 2018 ;68(4):361-370
    New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
    Background: Veterans with Gulf War Illness (GWI) experience chronic symptoms that include fatigue, pain, and cognitive impairment. This symptom cluster may be the consequence of impaired tissue oxygen delivery due to red blood cell (RBC) dysfunction.

    Objective: The purpose of this preliminary study was to determine whether the microrheological behavior of RBCs is altered in GWI. Read More

    Influence of different surface treatments of poly(n-butyl acrylate) networks on fibroblasts adhesion, morphology and viability.
    Clin Hemorheol Microcirc 2018 ;69(1-2):305-316
    Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany.
    Background: Physical and chemical characteristics of implant materials determine the fate of long-term cardiovascular devices. However, there is still a lack of fundamental understanding of the molecular mechanisms occurring in the material-tissue interphase. In a previous study, soft covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) were introduced as sterilizable, non-toxic and immuno-compatible biomaterials with mechanical properties adjustable to blood vessels. Read More

    Vasopressor support vs. liberal fluid administration in deep inferior epigastric perforator (DIEP) free flap breast reconstruction - a randomized controlled trial.
    Clin Hemorheol Microcirc 2018 ;69(1-2):37-44
    Center for Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
    Background: Perioperatively, patients' hemodynamics are modulated predominantly by intravenous fluid administration and vasoactive pharmacological support. Vasopressor agents are suspected to be detrimental on free flap survival by the cause of vasoconstriction of the pedicle with consecutive reduced overall flap perfusion and by aggravation of flap dissection.

    Objective: A novel, standardized fluid restrictive perioperative hemodynamic management was assessed for its feasibility in clinical practice in free flap patients undergoing breast reconstruction. Read More

    1 OF 45