2,317 results match your criteria Clinical Hemorheology and Microcirculation [Journal]


Effect of lipopolysaccharide on the adherence of human umbilical vein endothelial cells (HUVEC) on a natural substrate.

Clin Hemorheol Microcirc 2019 ;71(2):175-181

Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany.

 Polymers are often contaminated with lipopolysaccharides also known as endotoxins. Even small amounts of endotoxins can have strong effects on endothelial cell function so that the endothelialisation of cardiovascular implants might be hampered. An open question is how endothelial cells seeded on a body foreign substrate respond to shear load after adding Lipid A (LPA), the domain, which is responsible for much of the toxicity of gram-negative bacteria, and whether morphological changes of endothelial cells occur. Read More

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http://dx.doi.org/10.3233/CH-189409DOI Listing
January 2019
1 Read

Magnetocardiography detects left atrial dysfunction in paroxysmal atrial fibrillation.

Clin Hemorheol Microcirc 2019 Apr 1. Epub 2019 Apr 1.

Department of Medical II., Coburg Hospital, Coburg, Germany.

Background: Magnetocardiography (MCG) is a non-invasive technique and to characterize the magnetic field, a pseudo-current conversion was used. The role of MCG in detecting left atrial (LA) dysfunction in patients with paroxysmal atrial fibrillation (PAF) is unknown.

Objective: The aim of this study was to evaluate LA function using MCG in patients with PAF and healthy subjects, to identify possible indices to diagnose PAF. Read More

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http://dx.doi.org/10.3233/CH-180528DOI Listing
April 2019
1 Read
2.242 Impact Factor

Optical probe pressure effects on cutaneous blood flow.

Clin Hemorheol Microcirc 2019 Apr 1. Epub 2019 Apr 1.

Orel State University Named After I.S. Turgenev, Orel, Russia.

The variation of blood flow characteristics caused by the probe pressure during noninvasive studies is of particular interest within the context of fundamental and applied research. It has been shown previously that the weak local pressure induces vasodilation, whereas the increased pressure is able to stop the blood flow in the compressed area, as well as to significantly change optical signals.The blood flow oscillations measured by laser Doppler flowmetry (LDF) characterize the functional state of the microvascular system and can be used for noninvasive diagnostics of its abnormality. Read More

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http://dx.doi.org/10.3233/CH-180459DOI Listing

Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Background: Rho-kinase, an effector of the small GTPase RhoA, is known to be a novel inhibitory regulator of eNOS in endothelial cells under basal conditions and disease states. However, although RBC possesses active RhoA/Rho-kinase pathway, Rho-kinase mediated eNOS regulation has not been investigated in RBC, so far.

Objective: The aim of the present study is to investigate whether eNOS activity is regulated by Rho-kinase under basal conditions and to evaluate whether inhibition of this enzyme causes eNOS activation and intracellular NO production in RBC. Read More

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http://dx.doi.org/10.3233/CH-190578DOI Listing

Current opinions about the definition of critical limb ischemia: A debate still open after three decades.

Authors:
Romeo Martini

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Unitá Operativa di Angiologia, Azienda Ospedaliera Universitaria di Padova, Padova, Italy.

Critical limb Ischemia (CLI) is the most advanced stage of peripheral arterial disease. It is clinically defined as rest pain with or without skin ulcer or gangrene and carries a very poor prognosis with a high rates of limb amputation and cardiovascular mortality. Despite the first definition of CLI has been published more than 30 years ago, the debate about what it really is, is still open. Read More

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http://dx.doi.org/10.3233/CH-190576DOI Listing
March 2019
6 Reads

Contrast-enhanced ultrasound (CEUS) for the diagnosis of hypoechoic hepatic hemangioma in clinical practice.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Aim: To investigate the specific findings and characteristics of real-time contrast-enhanced ultrasound (CEUS) in hypoechoic hepatic hemangioma.

Methods: A total of 101 lesions in 83 patients were included. Analysis was made of the relationship between tumor size and CEUS enhance patterns in arterial phase, portal phase and delayed phase, phase changes, echoic changes in perfusion regression stage and filling defect. Read More

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http://dx.doi.org/10.3233/CH-190558DOI Listing
March 2019
2 Reads

Relationship of serum inflammatory cytokines with anemia and vascular endothelial function in children with systemic lupus erythematosus.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Objective: To analyze the relationship of the serum levels of inflammatory cytokines with the degree of anemia and vascular endothelial function in children with systemic lupus erythematosus (SLE), as well as to explore the predictive value of risk factors for SLE in children.

Methods: A total of 88 patients with SLE diagnosed in the Pediatric Department of our hospital from March 2015 to February 2017 were selected as the observation group, and 30 healthy controls with comparable age were selected as the control group. Basic characteristics of all enrolled individuals, such as age, sex, height and weight, and the related biochemical indexes, including the levels of inflammatory cytokines [C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR)], blood routine test including hemoglobin (Hb), platelet (PLT) and mean corpuscular volume as well as related indexes of vascular endothelial function, such as homocysteine (Hcy), carbonic oxide (NO), endothelial nitric oxide synthase (eNOS) were measured. Read More

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http://dx.doi.org/10.3233/CH-180492DOI Listing
March 2019
2 Reads

Influence of acute reduction of blood viscosity on endothelial function.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Background: The relationship between blood viscosity (BV) and endothelial function is rather complex. An increase in BV causes an increase in blood flow resistance, with negative hemodynamic effects; on the other hand, a moderate increase in BV causes an increase in wall stress shear (WSS), and consequent beneficial effects. As a matter of fact, the effect of changes in BV on endothelial function is not yet clear. Read More

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http://dx.doi.org/10.3233/CH-180446DOI Listing
March 2019
10 Reads

Red blood cell aggregation, disaggregation and aggregate morphology in autologous plasma and serum in diabetic foot disease.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Background: Diabetes mellitus is frequently associated with microcirculation pathology and hemorheological disorders.

Methods: 24 patients with diabetic foot and 22 healthy subjects were recruited. RBC aggregation, disaggregation and morphology of aggregates were determined in autologous plasma and serum. Read More

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http://dx.doi.org/10.3233/CH-180405DOI Listing

Effects of topical negative pressure therapy on perfusion and microcirculation of human skin.

Clin Hemorheol Microcirc 2019 Mar 16. Epub 2019 Mar 16.

Background: Topical negative pressure wound therapy (TNPWT) is one of the most frequently used techniques in wound treatment. But the underlying mechanism remains unclear. One possible explanation is an improved microcirculation by TNPWT. Read More

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http://dx.doi.org/10.3233/CH-180536DOI Listing

Impact of thyroid nodule sizes on the diagnostic performance of Korean thyroid imaging reporting and data system and contrast-enhanced ultrasound.

Clin Hemorheol Microcirc 2019 Mar 7. Epub 2019 Mar 7.

Department of Ultrasound, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China.

Objective: This study aimed to evaluate the impact of thyroid nodule sizes on the diagnostic performance of Korean thyroid imaging reporting and data system (TIRADS) and contrast-enhanced ultrasound (CEUS).

Methods: In total, 308 consecutive patients with 382 thyroid nodules underwent US-guided FNA or surgery were included in this retrospective study. The nodule size was classified into 3 categories: ≤10 mm (group A), 10-20 mm (group B), and ≥20 mm (group C). Read More

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http://dx.doi.org/10.3233/CH-180545DOI Listing
March 2019
3 Reads

Sublingual microcirculation in pancreatico-biliary surgery: An observational study.

Clin Hemorheol Microcirc 2019 Mar 2. Epub 2019 Mar 2.

Department of Surgery, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Background: An observational cohort study was conducted to identify potential sublingual microcirculation parameters as a target for goal-directed fluid therapy.

Methods: Patients that were scheduled for an open elective pancreatico-biliary surgery in Erasmus Medical Center were included. All patients underwent sublingual microcirculatory measurement at three time points: one day before surgery (T0), within the first 24 hours after surgery (T1) and on the fourth day after surgery (T2). Read More

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http://dx.doi.org/10.3233/CH-180448DOI Listing

Feasibility of dynamic three-dimensional contrast-enhanced ultrasound in focal liver lesions: Image quality evaluation and correlation of quantification with two-dimensional contrast-enhanced ultrasound.

Clin Hemorheol Microcirc 2019 Mar 7. Epub 2019 Mar 7.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Dynamic three-dimensional contrast-enhanced ultrasound (3D-CEUS) with quantitative analysis is updated in recent years.

Objective: To explore the feasibility of dynamic 3D-CEUS in evaluation of dynamic vascular patterns of focal liver lesions (FLL), and to analyze the correlation of time-intensity curve (TIC) parameters between dynamic 3D-CEUS and two-dimensional CEUS (2D-CEUS).

Methods: Dynamic 3D-CEUS and 2D-CEUS were both carried out in 106 FLL cases with SonoVue. Read More

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http://dx.doi.org/10.3233/CH-180531DOI Listing

The clinical role of contrast enhanced ultrasound in differential diagnosis of BI-RADS 4 breast disease.

Clin Hemorheol Microcirc 2019 Mar 2. Epub 2019 Mar 2.

Department of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Objective: To clarify the clinical role of contrast enhanced ultrasound (CEUS) in predicting BI-RADS 4 breast disease.

Methods: A total of 92 sites of BI-RADS 4 breast diseases were reassessed by routine ultrasound and CEUS. The main indicators of routine ultrasound, CEUS and the combination of the two modalities were picked up by binary logistic regression analysis, scoring 0 for benign and 1 for malignant characteristics with pathology as referential standard to generate corresponding score systems of them. Read More

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http://dx.doi.org/10.3233/CH-180495DOI Listing
March 2019
2 Reads

Virtual Touch Tissue Imaging and Quantification (VTIQ) combined with the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) for malignancy risk stratification of thyroid nodules.

Clin Hemorheol Microcirc 2019 Mar 2. Epub 2019 Mar 2.

In-Patient Ultrasound Department, Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, Heilongjiang prov, China.

Objective: This study was conducted to investigate the diagnostic performance of Virtual Touch Tissue Imaging and Quantification (VTIQ), combined with the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) in differentiating malignant and benign thyroid nodules.

Methods: A total of 130 thyroid nodules in 128 patients were included. The diagnostic performance of conventional ultrasound (US), VTIQ, and the combination of these two techniques was calculated and compared according to the area under the receiver operating characteristic curve (AUROC), for sensitivity, specificity, and accuracy. Read More

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http://dx.doi.org/10.3233/CH-180477DOI Listing
March 2019
11 Reads

Morphometry of the normal retinal periarteral capillary-free zone and changes during severe nonproliferative diabetic retinopathy.

Clin Hemorheol Microcirc 2019 Feb 23. Epub 2019 Feb 23.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To explore the normal morphological features of the retinal periarteral capillary free zone (paCFZ) and the changes associated with severe non-proliferative diabetic retinopathy (NPDR) by optical coherence tomography angiography (OCTA).

Methods: A total of 148 normal subjects and 115 patients with severe NPDR were enrolled. Spectral-domain OCTA was used to acquire the image with a Cirrus prototype. Read More

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http://dx.doi.org/10.3233/CH-180458DOI Listing
February 2019

Comparison of exercise electrocardiography and magnetocardiography for detection of coronary artery disease using ST-segment fluctuation score.

Clin Hemorheol Microcirc 2019 Feb 8. Epub 2019 Feb 8.

Coburg Hospital, 2nd Medical Department, Coburg, Germany.

Background: Exercise electrocardiography (ECG) is frequently used as a diagnostic measure in patients with suspected coronary artery disease (CAD). However, it has low sensitivity for the detection of CAD. Magnetocardiography (MCG) has been proposed as an alternative tool to accurately diagnose CAD. Read More

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http://dx.doi.org/10.3233/CH-180485DOI Listing
February 2019
2 Reads

Terminologies regarding sickle cell retinopathy and maculopathy.

Clin Hemorheol Microcirc 2019 ;71(1):1-2

Laboratoire d'Excellence GR-Ex ≪ The red cell: from genesis to death ≫, PRES Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.3233/CH-190552DOI Listing
January 2019
1 Read

Can acoustic structural quantification be used to characterize the ultrasound echotexture of the peripheral zone of breast lesions?

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology and Interdisciplinary Ultrasound Centre and Ultrasound Research Laboratory, University Berlin, Charité, Berlin, Germany.

Background: Besides mammography, breast ultrasound is the most important imaging modality for women with suspected breast cancer. New software tools bear high potential for improved detectability and specification of malignant breast lesions.

Objective: To compare the halo depicted around malignant breast lesions by ultrasound using Acoustic Structure Quantification (ASQ) of raw image data with the echogenic rim seen in B-mode ultrasound. Read More

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http://dx.doi.org/10.3233/CH-180484DOI Listing
January 2019
1 Read

TAK733 attenuates adrenergic receptor-mediated cardiomyocyte hypertrophy via inhibiting ErkThr188 phosphorylation.

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Gangwon-do, Republic of Korea.

Background: Cardiac hypertrophy is an important risk factor for heart failure. The MEK-ERK axis has been reported as a major regulator in controlling cardiac hypertrophy. TAK733 is a potent and selective MEK inhibitor that suppresses cell growth in a broad range of cell lines. Read More

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http://dx.doi.org/10.3233/CH-180476DOI Listing
January 2019
1 Read

Effects of dance movement therapy on the rheological properties of blood in elderly women.

Clin Hemorheol Microcirc 2019 Jan 31. Epub 2019 Jan 31.

Department of Physiotherapy, University of Physical Education, Cracow, Poland.

Objective: The aim of this study was to analyse the effects of dance movement therapy exercises (DMT) on the rheological properties of blood in elderly women.

Methods: The study encompassed group of women (mean aged: 67 years), who were subjected to three-month dance movement therapy programme (n = 20). Blood samples from all the women were examined for their haematological, rheological, and biochemical parameters both prior to the study and three months thereafter. Read More

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http://dx.doi.org/10.3233/CH-180470DOI Listing
January 2019
9 Reads

Biomarkers of endothelial injury in plasma are dependent on kidney function.

Clin Hemorheol Microcirc 2019 Jan 31. Epub 2019 Jan 31.

Department of Anesthesiology and Intensive Care, and Department of Medical and Health Sciences (IMH), Linköping University, Linköping, Sweden.

Background: Injury (shedding) of the endothelial glycocalyx layer, which alters local blood flow and microvascular permeability, is assessed by measuring components of this layer in circulating blood. The influence of renal function on their concentrations is unknown.

Methods: Plasma and urine concentrations of three shedding products (syndecan-1, hyaluronic acid, and heparan sulfate) and creatinine were measured over 5 hours in 15 healthy volunteers and 15 postoperative patients; this guaranteed a spread of kidney functions. Read More

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http://dx.doi.org/10.3233/CH-180444DOI Listing
January 2019

A study on role and mechanism of TLR4/NF-κB pathway in cognitive impairment induced by cerebral small vascular disease.

Clin Hemorheol Microcirc 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurology, Gansu Provincial People's Hospital, Lanzhou, Gansu, China.

Objective: To investigate the role and potential mechanism of Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway in cognitive impairment induced by cerebral small vascular disease (CSVD), so as to provide a reference for the clinical treatment of CSVD-induced cognitive impairment.

Methods: Mice with TLR4 gene knockout (n = 20) and those with wild-type TLR4 gene (n = 40) aged 8-10 weeks old were divided into blank control group (Control group, n = 20), wild-type + CSVD group (WT + CSVD group, n = 20) and TLR4 gene knockout + CSVD group (TLR4 KO + CSVD group, n = 20). Allogeneic thrombosis (particle diameter: 50-70 mm) was injected to the mouse's external carotid artery to create a model of learning and memory dysfunction. Read More

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http://dx.doi.org/10.3233/CH-180515DOI Listing
January 2019
5 Reads
2.242 Impact Factor

Stiffness distribution in the ablated zone after radiofrequency ablation for liver: An ex-vivo study with a tissue elastometer.

Clin Hemorheol Microcirc 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the stiffness distribution in the ablated zone after radiofrequency ablation (RFA), we used a device called tissue elastometer based on gross liver samples.

Materials: AND METHODS: Twelve freshly excised porcine livers were subject to RFA under a same setup to form elliptic ablated samples. Each sample was cut open for gross examination, and then the surface of the section plane was sliced into one piece for Young's modulus test using the tissue elastometer. Read More

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http://dx.doi.org/10.3233/CH-180404DOI Listing
January 2019
1 Read

Changes of perfusion patterns of surgical wounds under application of closed incision negative pressure wound therapy in postbariatric patients1.

Clin Hemorheol Microcirc 2019 Jan 14. Epub 2019 Jan 14.

Department of Plastic and Hand Surgery University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Negative pressure wound therapy applied over closed incisions (ciNPT) has been shown to influence wound healing. Therefore, the aim of this study was to examine the short-term effects of ciNPT on skin perfusion patterns in postbariatric wounds.

Methods: 17 patients were included. Read More

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http://dx.doi.org/10.3233/CH-180450DOI Listing
January 2019
9 Reads

Evaluation of plasma cell mastitis with superb microvascular imaging.

Clin Hemorheol Microcirc 2018 Jan 9. Epub 2018 Jan 9.

Department of Ultrasound, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China.

Background: Plasma cell mastitis (PCM), a common type of mastitis often mimics malignancy clinically and radiologically.

Objective: The study was designed to explore the diagnostic value of superb microvascular imaging (SMI) in differentiating PCM from malignant breast lesions.

Methods: A total of 95 breast lesions underwent conventional ultrasound (US) and SMI examination between May 2016 and April 2018. Read More

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http://dx.doi.org/10.3233/CH-180468DOI Listing
January 2018
1 Read

Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome.

Clin Hemorheol Microcirc 2019 ;71(1):113-116

Department of Chemical and Materials Engineering, San José State University, San José, CA, USA.

Background: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are made worse by physical or mental exertion. While the etiology of the disease is still debated, evidence suggests oxidative damage to immune and hematological systems as one of the pathophysiological mechanisms of the disease. Read More

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http://dx.doi.org/10.3233/CH-180469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398549PMC
January 2019
23 Reads
2.242 Impact Factor

Influence of limited examination conditions on contrast-enhanced sonography for characterising liver lesions.

Clin Hemorheol Microcirc 2019 ;71(2):267-276

Department of Radiology and Interdisciplinary Ultrasound Department, University Hospital Regensburg, Regensburg, Germany.

Aim: To assess the influence of difficult examination conditions onto the diagnostic performance of CEUS (contrast-enhanced ultrasound) in focal liver lesions (FLL).

Methods: 77 liver CEUS examinations of 75 patients were analysed retrospectively. CEUS was performed as the first diagnostic procedure by one experienced sonographer after bolus injection of 1. Read More

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http://dx.doi.org/10.3233/CH-189417DOI Listing
January 2019
4 Reads

Recent advances in microfluidic platelet function assays: Moving microfluidics into clinical applications.

Clin Hemorheol Microcirc 2019 ;71(2):249-266

Department of Mechanical Engineering, Korea University, Seoul, Korea.

The analysis of platelet aggregation and thrombosis kinetics has significantly advanced with progress in microfluidic technology. However, the results of platelet aggregation tests do not fully reflect the observed clinical outcomes. To address the present unmet clinical needs, the basic but essential biology of platelets should be reconsidered in relation to the characteristics of microfluidic systems employed for platelet tests. Read More

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http://dx.doi.org/10.3233/CH-189416DOI Listing
January 2019
2 Reads
2.242 Impact Factor

Diagnostic performance of ultrasound strain elastography for differentiation of malignant breast lesions.

Clin Hemorheol Microcirc 2019 ;71(2):237-247

Department of Radiology, University Hospital Regensburg, Germany.

Objective: Objective of the study was to assess the performance of ultrasound strain elastography combined with conventional B-mode ultrasound to diagnose suspicious breast lesions (BI-RADS 4 and 5).

Methods: Between January 2015 and December 2017, a total of 86 patients (55±17.9 years) with solid or unclear, non-cystic breast lesions were enrolled in the study. Read More

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http://dx.doi.org/10.3233/CH-189415DOI Listing
January 2019
1 Read

Renal ischemia-reperfusion-induced metabolic and micro-rheological alterations and their modulation by remote organ ischemic preconditioning protocols in the rat.

Clin Hemorheol Microcirc 2019 ;71(2):225-236

Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet.

Objective: To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat.

Methods: In Control group the left femoral artery was cannulated and the left kidney was gently exposed. Read More

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http://dx.doi.org/10.3233/CH-189414DOI Listing
January 2019
3 Reads

Acute L-Arginine supplementation does not affect red blood cell aggregation and deformability during high intensity interval exercise in healthy men.

Clin Hemorheol Microcirc 2019 ;71(2):215-223

Department of Biological Sciences in Sport and Health, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.

Background: L-Arginine, the precursor of NO might be involved in improving the cardiovascular disorders via regulation of functional properties of erythrocytes.

Objective: This study investigated the effects of L-Arginine supplementation on responses of red blood cell (RBC) properties to high intensity interval exercise (HIIE).

Methods: Ten overweight healthy men participated voluntarily in the study and performed two HIIE trials with and without L-Arginine in two separate weeks. Read More

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http://dx.doi.org/10.3233/CH-189413DOI Listing
January 2019
1 Read

Shear-stress mediated nitric oxide production within red blood cells: A dose-response.

Clin Hemorheol Microcirc 2019 ;71(2):203-214

Menzies Health Institute, Griffith University, Gold Coast, Australia.

Background: Red blood cells (RBC) are exposed to varying shear stress while traversing the circulatory system; this shear initiates RBC-derived nitric oxide (NO) production.

Objective: The current study investigated the effect of varying shear stress dose on RBC-derived NO production.

Methods: Separated RBC were prepared with the molecular probe, diamino-fluoreoscein diacetate, for fluorometric detection of NO. Read More

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http://dx.doi.org/10.3233/CH-189412DOI Listing
January 2019
1 Read

Impact of intraoperative use of vasopressors in lower extremity reconstruction: Single centre analysis of 437 free gracilis muscle and fasciocutaneous anterolateral thigh flaps.

Clin Hemorheol Microcirc 2019 ;71(2):193-201

Centre of Plastic, Aesthetic, Hand and Reconstructive Surgery, University of Regensburg, Regensburg, Germany.

Background: While complication rates in free tissue transfers have continuously decreased over time due to improved techniques, the intraoperative use of vasopressors and their negative effects on flap microcirculation and patency of the anastomoses remains controversial. To further elucidate this matter, this retrospective study examines the effect of intraoperative vasopressors on free gracilis muscle and free fasciocutaneous anterolateral thigh (ALT) flaps for lower extremity reconstruction.

Methods: A total of 425 patients underwent 437 free flaps for lower limb reconstruction. Read More

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http://dx.doi.org/10.3233/CH-189411DOI Listing
January 2019
1 Read

Shear-induced platelet adherence and activation in an in-vitro dynamic multiwell-plate system.

Clin Hemorheol Microcirc 2019 ;71(2):183-191

Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies Helmholtz-Zentrum Geesthacht, Teltow, Germany.

Circulating blood cells are prone to varying flow conditions when contacting cardiovascular devices. For a profound understanding of the complex interplay between the blood components/cells and cardiovascular implant surfaces, testing under varying shear conditions is required. Here, we study the influence of arterial and venous shear conditions on the in vitro evaluation of the thrombogenicity of polymer-based implant materials. Read More

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http://dx.doi.org/10.3233/CH-189410DOI Listing
January 2019
6 Reads

Contrast-enhanced ultrasound (CEUS) and gallbladder diseases - A retrospective mono-center analysis of imaging findings with histopathological correlation.

Clin Hemorheol Microcirc 2019 ;71(2):151-158

Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany.

Background: Radiologic imaging, especially ultrasound has an important role in the assessment of gallbladder alteration. Contrast-enhanced ultrasound (CEUS) is an easy and fast imaging technique that overcomes the limitations of greyscale ultrasonography. It is a safe tool that can be used as an additional imaging modality in order to elucidate and differentiate gallbladder pathological findings. Read More

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http://dx.doi.org/10.3233/CH-189405DOI Listing
January 2019
2 Reads

Contrast-enhanced ultrasound (CEUS) for the evaluation of gallbladder diseases in comparison to cross-sectional imaging modalities and histopathological results.

Clin Hemorheol Microcirc 2019 ;71(2):141-149

Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany.

Background: The first method of choice for gallbladder alteration detection is the conventional ultrasound. Due to some imaging limitations, contrast-enhanced ultrasound (CEUS) has been widely used in the last years. CEUS is an additional modality that is able to depict microvessels flow and elucidate suspicious findings. Read More

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http://dx.doi.org/10.3233/CH-189404DOI Listing
January 2019
2 Reads

Coronary microvascular disease and clinical prognosis in deferred lesions: The index of microcirculatory resistance.

Clin Hemorheol Microcirc 2019 ;71(2):137-140

Division of Cardiology, Ulsan Medical Center, Ulsan Hospital, Ulsan, Republic of Korea.

While fractional flow reserve (FFR) is a good diagnostic index to assess the myocardial ischemia, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) can be used to address microvascular status without any significant epicardial disease. The independent predictors for FFR and IMR are totally different and acts differently on the macro- and micro-vascular dysfunction. In high FFR patients, low CFR and high IMR which indicates the presence of overt microvascular disease demonstrated poor prognosis. Read More

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http://dx.doi.org/10.3233/CH-189403DOI Listing
January 2019
1 Read

Evaluation of Laser-Doppler-Fluxmetry for the diagnosis of microcirculatory disorders.

Clin Hemorheol Microcirc 2019 ;71(2):129-135

University of Applied Sciences Fulda, Germany.

Background: The laser Doppler fluxmetry (LDF) is a non-invasive method to assess skin blood perfusion, measuring the flow of blood cells inside a tissue volume without harming the tissue. In the diagnosis of skin circulation disorders, the results of the LDF measurement are generally used in such a way that "normal" (or non-ill) or "pathological" values are achieved by comparison with a reference sample, for example of apparently healthy subjects.

Material And Methods: In this study, the values of LDF for the diagnosis of microcirculatory disorders in patients with coronary artery disease (n = 20) or in patients with microcirculatory disorders, already diagnosed by capillary microscopy (n = 46), were examined. Read More

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http://dx.doi.org/10.3233/CH-189402DOI Listing
January 2019
1 Read

Long-term outcome of open surgery in CVI patients concerning postoperative complications, perioperative hemodynamics and clinical efficacy, Part II1.

Clin Hemorheol Microcirc 2019 ;71(2):117-127

Dermatological Clinic of the University of Greifswald, Germany.

Background: Chronic venous disease (CVD) is extremely common worldwide with prevalence increasing with age. It is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its' endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. Read More

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http://dx.doi.org/10.3233/CH-189401DOI Listing
January 2019
3 Reads

Percutaneous irreversible electroporation of hepatocellular carcinoma: Contrast-enhanced ultrasound-findings during 1-year follow-up.

Clin Hemorheol Microcirc 2018 Dec 17. Epub 2018 Dec 17.

Institute for Radiology, University Hospital Regensburg, Regensburg, Germany.

Purpose: To assess the postprocedure findings after percutaneous irreversible electroporation (IRE) of hepatocellular carcinoma (HCC) in contrast-enhanced ultrasound (CEUS).

Materials And Methods: Percutaneous IRE was performed in a total of 22 patients with 24 HCC tumours following interdisciplinary tumour board review. The lesions were documented using CEUS before, immediately and within 24 hours after IRE. Read More

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http://dx.doi.org/10.3233/CH-180449DOI Listing
December 2018
2 Reads

Microvascular complications in orthokeratology (Ortho-K): A real-time study on the microvasculature of the bulbar conjunctiva in Ortho-K treatment.

Clin Hemorheol Microcirc 2018 Dec 12. Epub 2018 Dec 12.

Amazon Web Services, Seattle, WA, USA.

Orthokeratology (Ortho-K) is an over-night hard contact lens therapy, which physically reshapes the corneal curvature in order to stabilize or temporally eliminate myopia in patients. We hypothesize that the prolonged physical contact and mechanical pressure induced by the Ortho-K lenses may create lasting inadvertent effects and damages (microangiopathy), and may bring about unwanted changes in the microvasculature of the bulbar conjunctiva. Computer-assisted intravital microscopy (CAIM) was used to view, document (via videotaping) and objectively quantify (via computer-assisted image analysis) the real-time dynamic and morphometric characteristics of the conjunctival microcirculation in long-term (at least over one year) Ortho-K patients (n = 11) and matched non-user control subjects (n = 8). Read More

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http://dx.doi.org/10.3233/CH-189908DOI Listing
December 2018
2 Reads

Laser Doppler-based measurements of periarticular blood flux can be utilized for assessment of arthritis pain: A hypothesis.

Clin Hemorheol Microcirc 2019 ;71(2):171-174

Department of Pharmacology, Dalhousie University Halifax, Canada.

Arthritis often presents with serious pain of the affected joints. The pain results mainly from underlying inflammatory processes initiated by the immune response to the degenerative structural changes within the joints and is associated with microvascular vasodilation that increases articular blood flow. Laser Doppler-based methods facilitate reliable quantification of microvascular perfusion. Read More

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http://dx.doi.org/10.3233/CH-189408DOI Listing
January 2019
1 Read

Comparison of PIRADS 3 lesions with histopathological findings after MRI-fusion targeted biopsy of the prostate in a real world-setting.

Clin Hemorheol Microcirc 2019 ;71(2):165-170

Department of Clinical Radiology, Interdisciplinary Ultrasound-Center, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Introduction: We aimed to evaluate whether PIRADS 3 lesions in multiparametric MRI (mpMRI) represent a significant risk of prostate cancer (PCa) in a real-world setting of different referring radiologic institutes.

Materials And Methods: Between May 2015 and October 2017, a total of 408 patients were referred to our clinic for MRI-ultrasound fusion targeted biopsy of the prostate (FusPbx) due to suspected prostate cancer. In all patients, preoperatively an mpMRI of the prostate was performed by altogether 62 different radiologic institutes. Read More

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http://dx.doi.org/10.3233/CH-189407DOI Listing
January 2019
8 Reads

Papillary renal cell carcinoma in contrast-enhanced ultrasound (CEUS) - A diagnostic performance study.

Clin Hemorheol Microcirc 2019 ;71(2):159-164

Department of Radiology, Ludwig-Maximilians-University Munich, Grosshadern Campus, Munich, Germany.

Background: Renal cell carcinomas (RCC) represent a heterogeneous group of hypo- and hypervascularized malignancies. Using contrast-enhanced ultrasound (CEUS) specific imaging features of clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC) subtypes have been demonstrated. However, some RCCs show atypical imaging features making it difficult to distinguish between the subtypes. Read More

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http://dx.doi.org/10.3233/CH-189406DOI Listing
January 2019
2 Reads

Endothelial cell migration, adhesion and proliferation on different polymeric substrates.

Clin Hemorheol Microcirc 2018 ;70(4):511-529

Background: The formation of a functionally-confluent endothelial cell (EC) monolayer affords proliferation of EC, which only happens in case of appropriate migratory activity.

Aim Of The Study: The migratory pathway of human umbilical endothelial cells (HUVEC) was investigated on different polymeric substrates.

Material And Methods: Surface characterization of the polymers was performed by contact angle measurements and atomic force microscopy under wet conditions. Read More

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http://dx.doi.org/10.3233/CH-189317DOI Listing
April 2019
1 Read

Sonography of the renal allograft: Correlation between doppler sonographic resistance index (RI) and histopathology.

Clin Hemorheol Microcirc 2018 ;70(4):413-422

Abteilung für Nephrologie, Klinikum rechts der Isar der Technischen Universität München, Germany.

Introduction: Allograft rejection (AR), chronic allograft injury (CAI) and acute tubular necrosis (ATN) can lead to renal allograft dysfunction after kidney transplantation. Interstitial fibrosis/tubular atrophy (Banff classification 2005) describes chronic allograft injury with no specific etiology, thus explaining the common final endpoint of various (immunologic and non immunologic) etiologies. The aim of this study was to evaluate correlations between the Doppler sonographic RI-values and histopathological changes of renal allografts biopsies during rejection, acute tubular necrosis and chronic allograft injury as well as the influence of donor and recipient features on the intrarenal RI-values. Read More

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http://dx.doi.org/10.3233/CH-189306DOI Listing
April 2019
5 Reads

Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

Clin Hemorheol Microcirc 2019 ;71(2):277-289

Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.

Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis and immune modulatory function. Further, they can differentiate into smooth muscle cells or endothelial-like cells and secret pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Read More

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http://dx.doi.org/10.3233/CH-189418DOI Listing
January 2019
2 Reads

The relationship between the rheological behavior of RBCs and angiogenesis in the morbidly obese.

Clin Hemorheol Microcirc 2019 ;71(1):95-102

Department of General and Bariatric Surgery and Emergency Medicine in Zabrze, Medical University of Silesia, Katowice, Poland.

Objective: The aim of this study was to investigate the relationship between red blood cell (RBC) aggregation and deformability and angiogenesis parameters in obese patients.

Methods: We studied 35 obese subjects and 20 non-obese people as a control group. Angiogenesis was detected using Bio-Plex Pro Human Angiogenesis Multiplex Assays. Read More

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http://dx.doi.org/10.3233/CH-180420DOI Listing
January 2019
5 Reads

Characterization of thoracal fat depots - expression of adipokines and remodeling factors and impact of adipocyte conditioned media in fibroblast scratch assays.

Clin Hemorheol Microcirc 2018 ;70(3):267-280

Department of Cardiac Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Herzzentrum Dresden, Germany.

Adipose tissue is not only a connective tissue but also an endocrine organ secreting adipokines like Leptin and Adiponectin, lipokines such as palmitoileic acid and extracellular vesicles. These factors and the expression of matrix remodeling enzymes impact surrounding tissues via paracrine effects. The expression of selected secretion factors and the effect of adipocyte conditioned media from four thoracal adipose tissue origins - subcutaneous, perivascular, pericardial and epicardial adipose tissues - in a fibroblast proliferation/wound healing scratch assay model were investigated. Read More

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http://dx.doi.org/10.3233/CH-170341DOI Listing
January 2019
2 Reads