5,546 results match your criteria Clinical Gastroenterology and Hepatology[Journal]


Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Background & Aims: The optimal training method for endoscopic characterization of colorectal polyps using narrow-band imaging is uncertain, and sessile serrated lesions (SSLs) optical diagnosis data are lacking. We aimed to evaluate a comprehensive training program for real-time optical diagnosis of colorectal polyps, including SSLs.

Methods: We performed a single-institution prospective study of 15 endoscopists trained with the Workgroup Serrated Polyps and Polyposis classification system. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.019DOI Listing
February 2019

For Whom is Hepatocellular Carcinoma Surveillance after Sustained Virologic Response Cost Effective?

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology, Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington, Seattle WA; Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle WA.

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http://dx.doi.org/10.1016/j.cgh.2019.02.020DOI Listing
February 2019

Effect of Cotinine-verified Change in Smoking Status on Risk of Metachronous Colorectal Neoplasia After Polypectomy.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background & Aims: Previous assessments of colorectal neoplasia (CRN) recurrence after polypectomy used self-report to determine smoking status. We evaluated the association between change in smoking status and metachronous CRN risk after polypectomy using cotinine level in urine to determine tobacco exposure.

Methods: We performed a retrospective study of participants in the Kangbuk Samsung Health Study, in Korea, who underwent a screening colonoscopy examination and measurement of cotinine in urine samples. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.018DOI Listing
February 2019

Association Between Level of Fecal Calprotectin and Progression of Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Gastrointestinal Unit, Western General Hospital, Edinburgh, UK; University of Edinburgh, UK.

Background & Aims: Mucosal healing is associated with improved outcomes in patients with Crohn's disease (CD), but assessment typically requires ileocolonoscopy. Calprotectin can be measured in fecal samples to determine luminal disease activity in place of endoscopy-this measurement is an important component of the treat to target strategy. We investigated whether levels of fecal calprotectin associate with subsequent CD progression. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.017DOI Listing
February 2019
5 Reads

Use of Doppler Probe in Non-Variceal Upper-Gastrointestinal Bleeding is Less Costly and More Effective Than Standard of Care.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Background & Aims: Upper gastrointestinal bleeding is a common emergency and rebleeding is associated with an increased risk of death. Proper assessment of high-risk lesions and appropriate endoscopic hemostasis are required for the best outcomes. The endoscopic Doppler probe exam (DPE) allows for a more complete assessment of the stigmata of hemorrhage, providing better evaluation of the need for endoscopic hemostasis and determination of its completeness. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.016DOI Listing
February 2019
1 Read

Addition of Carvedilol to Gastric Variceal Obturation Does Not Decrease Recurrence of Gastric Variceal Bleeding in Patients With Cirrhosis.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background & Aims: Gastric variceal bleeding (GVB) frequently recurs after hemostasis by gastric variceal obturation (GVO). We performed a multicenter, randomized controlled trial to determine the efficacy of carvedilol plus GVO in secondary prophylaxis of GVB.

Methods: We performed a prospective study of 121 patients with cirrhosis (ages 20-80 years) with GVB proven by endoscopy within 24 hours of bleeding and stable hemodynamics for at least 3 days after initial GVO. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.021DOI Listing
February 2019

Reply.

Clin Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1016/j.cgh.2019.02.003DOI Listing
February 2019
1 Read

Reply to a Letter to the Editor.

Clin Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Professor, Kaohsiung Medical University, Vice Superintendent, Kaohsiung Municipal Ta-Tung Hospital, Visiting staff, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, TAIWAN, 100 Zih-You 1st Road, Kaohsiung City, Taiwan.

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http://dx.doi.org/10.1016/j.cgh.2019.02.015DOI Listing
February 2019
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Fibroscan For the Rest of Us-How to Incorporate Fibroscan into Management of Patients With Liver Disease.

Clin Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

University School of Medicine, Indianapolis, IN; Richard L. Roudebush VAMC Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.02.014DOI Listing
February 2019
1 Read

Does eradication of Helicobacter pylori cause inflammatory bowel disease?

Clin Gastroenterol Hepatol 2019 Feb 12. Epub 2019 Feb 12.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cgh.2019.02.013DOI Listing
February 2019
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Timing Isn't Everything for Diagnostic Colonoscopy After Positive Results From a Fecal Immunohistochemical Test.

Clin Gastroenterol Hepatol 2019 Feb 12. Epub 2019 Feb 12.

VA Puget Sound Health Care System, University of Washington School of Medicine, 1660 S. Columbian Way (111-Gastro) Seattle, WA 98108.

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http://dx.doi.org/10.1016/j.cgh.2019.02.011DOI Listing
February 2019

Metachronous Neoplasias Arise in a Higher Proportion of Colon Segments From Which Large Polyps Were Previously Removed, and Can be Used to Estimate Incomplete Resection of 10-20 mm Colorectal Polyps.

Clin Gastroenterol Hepatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Hanover, NH; Dartmouth Geisel School of Medicine, Hanover, NH; Department of Gastroenterology and Hepatology, Veterans Affairs Medical Center, White River Junction, VT, Vermont, United States. Electronic address:

Background & Aims: Incomplete resection of polyps could be an important cause of post-colonoscopy colorectal cancer. However, it is difficult to study progression of incompletely removed polyps or their clinical importance. We aimed to estimate incomplete polyp resection using risk of metachronous neoplasia per colon segment. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.047DOI Listing
February 2019

Refractory perforated gastric ulcer after particle beam radiation therapy followed by bevacizumab treatment.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology and Hepatology, Kitano Hospital, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.02.004DOI Listing
February 2019

Gastric Tumoral Melanosis: a Rare Manifestation of Successfully Treated Malignant Melanoma.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Department of General Medical Oncology, University Hospitals Leuven, KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cgh.2019.02.006DOI Listing
February 2019
1 Read

Pancreatic cysts: Let's start looking at the patient before poking at the cyst.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Center for Interventional Endoscopy, AdventHealth Orlando, Orlando, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.02.009DOI Listing
February 2019
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Don't Smoke 'em if you got 'em-Tobacco Exposure Increases Risk of Serrated Polyps.

Authors:
Seth D Crockett

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.02.010DOI Listing
February 2019

Healthcare Utilization and Costs for Patients With End-stage Liver Disease are Significantly Higher at the End of Life Compared to Those of Other Decedents.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

The Ottawa Hospital Research Institute, Ottawa, ON, Canada; Institute for Clinical Evaluative Sciences, Ottawa, ON, Canada; Bruyère Research Institute, Bruyère Centre of Learning, Research and Innovation in Long-Term Care, Ottawa, Ontario, Canada.

Background & Aims: Patients with end-stage liver disease (ESLD) have progressively complex medical needs. However, little is known about their end of life health care utilization or associated costs. We performed a population-based study to evaluate the end of life direct utilization and costs for patients with ESLD among health care sectors in the province of Ontario. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.046DOI Listing
February 2019
7.896 Impact Factor

Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address:

Background & Aims: The incidence and outcomes of alanine aminotransferase (ALT) flares during the natural history of chronic HBV infection has not been determined in a large, racially heterogeneous groups of patients in North America.

Methods: We collected data from the Hepatitis B Research Network-an observational cohort study of untreated adults with chronic HBV infection enrolled at 21 sites in the United States and Canada. Clinical and laboratory data were collected from 1587 participants (49. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.005DOI Listing
February 2019
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Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Danish Polyposis Registry, Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Background & Aims: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that increases risk for colorectal cancer (CRC). We assessed changes in the incidence and prevalence of CRC, and survival times, of patients with FAP participating in the Danish follow-up study.

Methods: We collected data from the Danish Polyposis Registry, a nationwide, complete registry of patients with FAP that includes clinical information, surgical procedures, follow-up findings, and pathology reports. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.008DOI Listing
February 2019
1 Read

American ancestry is a risk factor for suspected non-alcoholic fatty liver disease in Hispanic/Latino adults.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Hepatology, Loyola University Medical Center, Maywood IL.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) disproportionally affects Hispanic/Latino populations. However, the magnitude varies among Hispanic/Latino ethnic groups. We investigated the mechanisms of these disparities. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.007DOI Listing
February 2019
2 Reads

Preparing for Large-Scale Disruptions In Health Care Delivery: Nursing Strikes and Beyond.

Clin Gastroenterol Hepatol 2019 Feb 5. Epub 2019 Feb 5.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA; Institute for Health Care Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Center for Clinical Management Research, Department of Veterans Affairs, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.cgh.2019.02.001DOI Listing
February 2019

Decreasing Endoscopy No-Shows using Lean Improvement Framework.

Clin Gastroenterol Hepatol 2019 Feb 5. Epub 2019 Feb 5.

Durham VA Medical Center, Durham NC; Division of Gastroenterology, Duke University School of Medicine, Durham, NC; The Cooperative Studies Program Epidemiology Center (CSPEC)-Durham.

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http://dx.doi.org/10.1016/j.cgh.2019.02.002DOI Listing
February 2019

Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose.

Clin Gastroenterol Hepatol 2019 Feb 4. Epub 2019 Feb 4.

Division of Digestive and Liver Diseases, The University of Texas Southwestern Medical Center, Dallas, TX, United States; Grant Support-This study was supported by a grant from the National Institute for Diabetes and Digestive and Kidney Diseases (U01-DK-58369 ) to the University of Texas Southwestern Medical Center at Dallas.

Background Aims: Evaluation of patients with acute liver injury (ALI) or acute liver failure (ALF) often includes measurement of plasma levels of acetaminophen, to determine exposure and/or toxicity. However, once liver injury has developed, acetaminophen might be undetectable in plasma. We investigated the association between level of acetaminophen measured and outcomes of patients designated as having ALF or ALI due to acetaminophen toxicity. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.040DOI Listing
February 2019
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Long-term Outcomes of Antiviral Therapy in Patients with Advanced Chronic HBV Infection.

Clin Gastroenterol Hepatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Internal Medicine Yonsei University College of Medicine, Seoul; Liver Cirrhosis Clinical Research Center, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.01.044DOI Listing
February 2019
7.896 Impact Factor

Correction.

Authors:

Clin Gastroenterol Hepatol 2019 Feb 2. Epub 2019 Feb 2.

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http://dx.doi.org/10.1016/j.cgh.2019.01.006DOI Listing
February 2019
1 Read

Correction.

Authors:

Clin Gastroenterol Hepatol 2019 Feb 2. Epub 2019 Feb 2.

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http://dx.doi.org/10.1016/j.cgh.2019.01.007DOI Listing
February 2019
1 Read

Correction.

Authors:

Clin Gastroenterol Hepatol 2019 Feb 2. Epub 2019 Feb 2.

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http://dx.doi.org/10.1016/j.cgh.2019.01.008DOI Listing
February 2019

Association Between Renal Function Pattern and Mortality in Patients with Cirrhosis.

Clin Gastroenterol Hepatol 2019 Feb 1. Epub 2019 Feb 1.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, CA, USA. Electronic address:

Background & Aims: Renal dysfunction increases risk of death for patients with cirrhosis. We investigated whether mortality differs significantly among patients with acute kidney injury (AKI), chronic kidney disease (CKD), and both.

Methods: We performed a retrospective analysis of all non-status 1 adults on the waitlist for liver transplantation for at least 90 days, collected from the Organ Procurement and Transplantation Network registry from July 1, 2007 through July 1, 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193009
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http://dx.doi.org/10.1016/j.cgh.2019.01.043DOI Listing
February 2019
4 Reads

Validation of a Model for Identification of Patients With Compensated Cirrhosis at High Risk of Decompensation.

Clin Gastroenterol Hepatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.

Background & Aims: It is important to rapidly identify patients with advanced liver disease. Routine tests to assess liver function and fibrosis provide data that can be used to determine patients' prognoses. We tested the validated the ability of combined data from the ALBI and FIB-4 scoring systems to identify patients with compensated cirrhosis at highest risk for decompensation. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.042DOI Listing
February 2019
1 Read

No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study.

Clin Gastroenterol Hepatol 2019 Feb 1. Epub 2019 Feb 1.

Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Background & Aims: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).

Methods: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.041DOI Listing
February 2019
3 Reads
7.896 Impact Factor

Effect of Treatment on the Risk of Viral Infections in Inflammatory Bowel Disease.

Authors:
Philip B Miner

Clin Gastroenterol Hepatol 2019 Feb 1. Epub 2019 Feb 1.

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http://dx.doi.org/10.1016/j.cgh.2019.01.045DOI Listing
February 2019
2 Reads

Reply to Letter to the Editor regarding the Houston Consensus conference on testing for H. pylori infection in the United States.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Medicine, Michael E. DeBakey VA Medical Center, and Baylor College of Medicine, Houston, Tx. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.01.039DOI Listing
January 2019

Target and whirl signs: volvulus of intussuscepted colon in an infant.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Pediatric Surgery, Kanazawa Medical University, Uchinada, Japan, 1-1 Daigaku, Uchinada-machi, Kahokugun, Ishikawa, Japan.

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http://dx.doi.org/10.1016/j.cgh.2019.01.033DOI Listing
January 2019
1 Read

Successful endoscopic removal of a large pancreatic stone in a patient after pancreaticoduodenectomy.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Departments of Gastroenterology and Hepatology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

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http://dx.doi.org/10.1016/j.cgh.2019.01.028DOI Listing
January 2019

Sigmoid gallstone ileus.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

General and Digestive Surgery Department. Reina Sofía University Hospital. Cordoba. Spain.

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http://dx.doi.org/10.1016/j.cgh.2019.01.031DOI Listing
January 2019
1 Read

Primary large anorectal melanoma presenting as intermittent rectal bleeding and mimicking a hemorrhoid.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Division of Colorectal Surgery, Medstar Washington Hospital Center, Washington, DC.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193008
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http://dx.doi.org/10.1016/j.cgh.2019.01.034DOI Listing
January 2019
1 Read

A rare cause of pneumatosis intestinalis.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

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http://dx.doi.org/10.1016/j.cgh.2019.01.037DOI Listing
January 2019

Localized Gastrointestinal Amyloidosis Manifesting as an Isolated Colonic Ulcer: A Rare Cause of Hematochezia.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Inflammatory Bowel Disease Unit, Department of Medicine, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cgh.2019.01.035DOI Listing
January 2019

Reply to Methodological issues on prediction of hepatocellular carcinoma after sustained virological responses.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.cgh.2019.01.038DOI Listing
January 2019

Biliary ascariasis - an unusual case of obstructive jaundice.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Department of General Surgery, Khoo Teck Puat Hospital, Singapore 768828.

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http://dx.doi.org/10.1016/j.cgh.2019.01.032DOI Listing
January 2019

A pancreatic lymphoepithelial cyst with floating-balls.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Diagnostics and Public Health, G.B. Rossi University Hospital, Verona, Italy.

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http://dx.doi.org/10.1016/j.cgh.2019.01.029DOI Listing
January 2019
1 Read

A conceptual approach to understanding treatment response in eosinophilic esophagitis.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Division of Pediatric Gastroenterology, University of Illinois College of Medicine, Peoria, IL.

While the diagnosis and initial treatment of eosinophilic esophagitis (EoE) are becoming more standardized, there are still major gaps in knowledge related to measuring treatment response. One such question centers on how to measure treatment response and what treatment end-points should be. This impacts not only patient care and engagement in decision-making, but also the field of drug development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193007
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http://dx.doi.org/10.1016/j.cgh.2019.01.030DOI Listing
January 2019
2 Reads

Annular Pancreas.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.01.036DOI Listing
January 2019
3 Reads

Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Transfusion Medicine and Hematology - Translational Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Background & Aims: In patients with nonalcoholic fatty liver disease (NAFLD), steatohepatitis (NASH) is a risk factor for development of fibrosis. However, fibrosis has been observed in livers of patients without NASH. We aimed to estimate the prevalence of fibrosis in patients without NASH and risk factors for fibrosis. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.027DOI Listing
January 2019
2 Reads

Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology & Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, NC; Division of Gastroenterology, Hepatology, and Nutrition, Deparment of Medicine, Center for Liver Diseases, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA. Electronic address:

Background & Aims: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly due to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies.

Methods: We performed a cross-sectional study of 3453 consecutive patients with either early or advanced liver disease (1699 patients with early and 1754 with advanced liver disease) seen at 17 tertiary care liver or gastrointestinal units worldwide, from August 2015 through March 2017. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.026DOI Listing
January 2019
5 Reads

Machine Learning-based Development and Validation of a Scoring System for Screening High Risk Esophageal Varices.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA, 91342. Electronic address:

Background & Aims: Many patients with cirrhosis who undergo esophagogastroduodenoscopy (EGD) screening for esophageal varices (EVs) are found to have no or only small EVs. Endoscopic screening for EVs is therefore a potentially deferrable procedure that increases patient risk and healthcare cost. We developed and validated a scoring system, based on readily-available data, to identify patients with EVs varices that need treatment. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.025DOI Listing
January 2019
1 Read

Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background & Aims: Under the Chicago Classification of esophageal motility disorders, esophagogastric junction outflow obstruction (EGJOO) includes a varied clinical spectrum that results in diagnostic and management difficulties. We aimed to demonstrate that including upright swallows during high-resolution manometry (HRM) helps identify patients with clinically significant EGJOO.

Methods: We performed a retrospective study of consecutive patients diagnosed with EGJOO on HRM from January 2015 through July 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193007
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http://dx.doi.org/10.1016/j.cgh.2019.01.024DOI Listing
January 2019
7 Reads

Transnasal Endoscopy in Unsedated Children With Eosinophilic Esophagitis Using Virtual Reality Video Goggles.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Digestive Health Institute, Children's Hospital Colorado, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine; Aerodigestive Program, Children's Hospital Colorado.

Background & Aims: Evaluation and treatment of children with eosinophilic esophagitis (EoE) requires serial endoscopic, visual, and histologic assessment by sedated esophagogastroduodenoscopy (EGD). Unsedated transnasal endoscopy (TNE) was reported to be successful in a pilot study of children. We evaluated video goggle and virtual reality-based unsedated TNE in children with EoE, collecting data on rates of completion, adverse events, and adequacy of visual and histologic findings. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.023DOI Listing
January 2019
1 Read

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Clin Gastroenterol Hepatol 2019 Feb;17(3):576

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183090
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http://dx.doi.org/10.1016/j.cgh.2018.08.063DOI Listing
February 2019
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Neutrophil-to-Lymphocyte Ratio; an Independent Predictor of Mortality or Just a Surrogate Marker of Underlying Complications?

Clin Gastroenterol Hepatol 2019 Feb;17(3):574

2nd Department of Internal Medicine, General Hospital of Heraklion "Venizeleio-Pananeio", Leoforos Knossou, Heraklion, Greece.

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http://dx.doi.org/10.1016/j.cgh.2018.05.048DOI Listing
February 2019