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    5127 results match your criteria Clinical Gastroenterology and Hepatology[Journal]

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    Non-alcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Center for Outcomes Research in Liver Disease, Washington, DC, United States.
    Background: While hepatitis B and C have been the main drivers of hepatocellular carcinoma (HCC), non-alcoholic steatohepatitis (NASH) has recently become an important cause of HCC. The aim of this study was to assess the causes of HCC among liver transplant (LT) candidates in the U.S. Read More

    Video-based Assessments of Colonoscopy Inspection Quality Correlate with Quality Metrics and Highlight Areas for Improvement.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine; Chicago, IL.
    Background & Aims: Adenoma detection rate (ADR) and serrated polyp detection rate (SDR) vary significantly among colonoscopists. Colonoscopy inspection quality (CIQ) is the quality with which a colonoscopist inspects for polyps and may explain some of this variation. We aimed to determine the relationship between CIQ and historical ADRs and SDRs in a cohort of colonoscopists and assess whether there is variation in CIQ components (fold examination, cleaning, and luminal distension) among colonoscopists with similar ADRs and SDRs. Read More

    Magnetic Resonance vs Transient Elastography Analysis of Patients With Non-alcoholic Fatty Liver Disease: a Systematic Review and Pooled Analysis of Individual Participants.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Nonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California at San Diego, La Jolla, California, USA; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California, USA; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California, USA. Electronic address:
    Background & Aims: Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have compared the diagnostic performance of MRE vs TE in patients with nonalcoholic fatty liver disease (NAFLD). We conducted a pooled analysis of individual participant data from published studies to compare the diagnostic performance of MRE vs TE for staging of liver fibrosis in patients with NAFLD, using liver biopsy as reference. Read More

    Incidence of Upper and Lower Gastrointestinal Bleeding in New Users of Low-dose Aspirin.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain.
    Background & Aims: There are few data on the incidence of upper and lower gastrointestinal bleeding (UGIB and LGIB) from observational studies of low-dose aspirin users. We aimed to estimate incidence rates of UGIB and LGIB in a large cohort of new users of low-dose aspirin in the United Kingdom, with sub-analyses of hospitalization status and fatalities.

    Methods: We performed a population-based study of 199,079 new users of low-dose aspirin (median age, 64. Read More

    Heterogeneity in Clinical, Endoscopic, and Histologic Outcome Measures and Placebo Response Rates in Clinical Trials of Eosinophilic Esophagitis: A Systematic Review.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address:
    Background & Aims: Agents are being developed for treatment of eosinophilic esophagitis (EoE). However, it is not clear what outcome measures would best determine the efficacy and safety of these agents in clinical trials. We performed a systematic review of outcomes used in randomized placebo-controlled trials of EoE and we estimate the placebo response and rates of remission. Read More

    Statin Therapy Does Not Reduce Liver Fat Scores in Patients Receiving Antiretroviral Therapy for HIV Infection.
    Clin Gastroenterol Hepatol 2018 Jun 13. Epub 2018 Jun 13.
    Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center, Cleveland, OH; Rainbow Babies and Children's Hospital, Cleveland, OH. Electronic address:
    Background & Aims: Therapies are needed to limit progression of fatty liver diseases in patients with HIV infection. We analyzed data from a prospective study of the effects of rosuvastatin (a statin) on hepatic steatosis in HIV-positive adults.

    Methods: We performed secondary analysis of data from a double-blind trial of adult patients with HIV infection (78% male; 68% African American; mean age, 46 years; body mass index, 29 kg/m; HIV1 RNA<1000 copies/mL; LDL-cholesterol <130 mg/dL) receiving antiretroviral therapy. Read More

    Timing of Gastrointestinal Bleeding After Implantation of Left Ventricular Assist Devices Associates With Anatomic Location, Presentation, and Management.
    Clin Gastroenterol Hepatol 2018 Jun 12. Epub 2018 Jun 12.
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address:
    Background & Aims: Continuous-flow left ventricular assist devices (LVADs) for advanced heart failure have been associated with gastrointestinal bleeding (GIB). We examined the association between time of GIB after LVAD implantation and bleeding location (determined by endoscopy), etiology, and patient outcomes.

    Methods: We performed a retrospective study of consecutive patients who underwent implantation of continuous-flow LVADs from 2008 through 2015. Read More

    Safety and Efficacy of Budesonide Oral Suspension Maintenance Therapy in Patients With Eosinophilic Esophagitis.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
    Background & Aims: We aimed to determine the safety and efficacy of budesonide oral suspension (BOS) maintenance therapy in patients with eosinophilic esophagitis (EoE).

    Methods: We performed an open-label extension study of a 12-week, multicenter, randomized, double-blind, placebo-controlled trial. Patients with EoE (11-40 years old) who completed double-blind BOS (n=45) or placebo therapy (n=37) received 24 weeks' open-label BOS (2. Read More

    Maintenance Treatment of Eosinophilic Esophagitis With Swallowed Topical Steroids Alters Disease Course Over A 5-Year Follow-Up Period in Adult Patients.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
    Background & Aims: Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. We evaluated the long-term effectiveness of STC therapy for adults with EoE.

    Methods: We performed a retrospective study using the Swiss EoE database. Read More

    Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients with Chronic Functional Diarrhea.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
    Background & Aims: Patients with bile acid diarrhea (BAD) are identified based on increased levels of BAs in fecal samples collected over a 48-hr period while on a 100-gram fat diet (48-hr BA), retention of Se-labeled homocholic acid taurine, or serum levels of C4 or FGF19. BAD increases fecal weight and colonic transit. We investigated whether results of tests for BAD associate with increased fecal weight and more rapid colonic transit over a 24- or 48-hr period in patients with irritable bowel syndrome with diarrhea (IBS-D). Read More

    Factors Associated With Recurrence of Barrett's Esophagus After Radiofrequency Ablation.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, Texas; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas. Electronic address:
    Background & Aims: Radiofrequency ablation (RFA) is effective treatment for Barrett's esophagus (BE). However, some patients have recurrence after complete eradication of intestinal metaplasia (CEIM). We investigated the incidence of and factors associated with BE recurrence, with or without neoplasia, after RFA and CEIM using data from the national Veterans Affairs (VA) healthcare system. Read More

    Serum Level of Antibodies Against Hepatitis B Core Protein Is Associated With Clinical Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:
    Background & Aims: Levels of antibodies against the hepatitis B virus (HBV) core protein (anti-HBc) have been associated with response to nucleos(t)ide analogue and (peg)interferon therapy in patients with chronic HBV infection. We performed a prospective study to determine whether the total serum level of anti-HBc level (immunoglobulins M and G) is associated with clinical relapse after discontinuation of nucleos(t)ide analogue-based therapy.

    Methods: We collected data from patients with chronic HBV infection who discontinued nucleos(t)ide analogue therapy according to pre-specified stopping criteria, recruited from November 2012 through July 2016 at an academic hospital in Guangzhou, China. Read More

    High prevalence of hepatic fibrosis, measured by Elastography, in a Population-based study of Mexican Americans.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    The University of Texas Health Science Center at Houston School of Public Health, Brownsville Regional Campus, Brownsville, TX, USA.
    Background & Aims: Hepatic fibrosis is a primary risk factor for cirrhosis and hepatocellular carcinoma, which affect a disproportionate number of Hispanics in the United States. We aimed to determine the prevalence of significant fibrosis, measured by point shear-wave elastography (pSWE), and determine characteristics of hepatic fibrosis and simple steatosis in a population-based study of Mexican American Hispanics in south Texas.

    Methods: Liver stiffness was measured by pSWE, performed by 2 separate operators, for 406 participants in the Cameron County Hispanic Cohort from 2015 through 2017. Read More

    A rare case of hyperplastic proximal esophageal polyps with foveolar dysplasia.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center.
    A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. Read More

    Diagnosis and treatment of rumination syndrome.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Background: Rumination syndrome is a functional gastrointestinal disorder characterized by effortless post-prandial regurgitation. The disorder appears uncommon, although only limited epidemiological data are available. Awareness of the characteristic symptoms is essential for recognizing the disorder, and thus avoiding the long delay in diagnosis which many patients experience. Read More

    Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997-2014.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Surveillance and Health Services Research, American Cancer Society, Atlanta, GA.
    Background & Aims: There is limited information on contemporary incidence rates and trends, by race, ethnicity, and age, for major subtypes of esophageal and gastric cancer in the United States. We examined the most recent nationwide incidence data for esophageal squamous cell carcinoma, esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) by race, ethnicity, and age in the United States.

    Methods: Average contemporary incidence rates (2010-2014) and annual percent changes in rates (from 1997 through 2014) by race, ethnicity, and age were calculated for each cancer subtype using nationwide data compiled by the North American Association of Central Cancer Registries. Read More

    Risk of Malignancy in Adenomas Detected During Screening Colonoscopy.
    Clin Gastroenterol Hepatol 2018 Jun 11. Epub 2018 Jun 11.
    Department of Medical Biometry and Epidemiology , University Hospital Hamburg-Eppendorf, Hamburg, Germany.
    Background & Aims: A higher incidence of proximal interval cancers after colonoscopy has been reported in several follow-up studies. One possible explanation for this might be that proximally located adenomas have greater malignant potential. The aim of the present study was to assess the risk of malignancy in proximal versus distal adenomas in patients included in a large screening colonoscopy database; adenoma shape and the patients' age and sex distribution were also analyzed. Read More

    Racial and Ethnic Differences in Presentation and Outcomes of Hepatocellular Carcinoma.
    Clin Gastroenterol Hepatol 2018 May 31. Epub 2018 May 31.
    Department of Internal Medicine, UT Southwestern Medical Center and Parkland Health and Hospital System, Dallas, TX; Department of Clinical Sciences, University of Texas Southwestern, Dallas, TX.
    Background & Aims: Racial and ethnic minorities are reported to have higher mortality related to hepatocellular carcinoma (HCC) than non-Hispanic whites. However, it is not clear whether differences in tumor characteristics or liver dysfunction among racial or ethnic groups affect characterization of causes for this disparity. We aimed to characterize racial and ethnic differences in HCC presentation, treatment, and survival. Read More

    Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background & Aims: Functional nausea and vomiting disorders (FNVDs) are classified as chronic nausea and vomiting syndrome (CNVS) or cyclic vomiting syndrome (CVS) - CVS includes cannabinoid hyperemesis syndrome. We investigated the population prevalence of FNVDs, their characteristics, and associated factors.

    Methods: In the year 2015, an Internet cross-sectional health survey was completed by 5931 adults in the general populations of 3 English-speaking countries; 2100 participants were in the United States, Canada, or the United Kingdom. Read More

    Accuracy of Endoscopic Ultrasound Imaging in Distinguishing Celiac Ganglia from Celiac Lymph Nodes.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Division of Gastroenterology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota. Electronic address:
    Background & Aims: Endoscopic ultrasound (EUS) allows visualization of celiac lymph nodes (CLNs) and celiac ganglia (CG). Reliably distinguishing these structures is important for tumor staging and CG ablative therapies. We aimed to evaluate the accuracy of EUS in distinguishing CLNs from CG using a strict cytopathology reference standard. Read More

    Increased Risk of Herpes Zoster Infection in Patients with Inflammatory Bowel Diseases in Korea.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Departments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:
    Background & Aims: Few data are available on risk of herpes zoster (HZ) infection in Asian patients with inflammatory bowel diseases (IBD). We investigated whether patients with IBD in Korea have an increased risk of HZ and sought to identify risk factors for infection.

    Methods: We performed a nationwide population-based study and a hospital-based, nested case-control study. Read More

    Barriers to Follow-Up Colonoscopies for Patients With Positive Results From Fecal Immunochemical Tests During Colorectal Cancer Screening.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), Los Angeles, California; Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California Los Angeles, Los Angeles, California.
    Background & Aims: Colorectal cancer is common yet largely preventable. The fecal immunochemical test (FIT) is a highly recommended screening method, but patients with positive results must receive a follow-up colonoscopy to determine if they have precancerous or cancerous lesions. We characterized colonoscopic follow-up evaluations and reasons for lack of follow-up in a Veterans Affairs (VA) cohort. Read More

    Evaluations of Lifestyle, Dietary, and Pharmacologic Treatments for Pediatric Non-Alcoholic Fatty Liver Disease-a Systematic Review.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Liver Unit, Queen Elizabeth University Hospital Birmingham, Brmingham, UK.
    Background & Aims: There are no approved treatments for pediatric non-alcoholic fatty liver disease (NAFLD) and there is a lack of consensus on the best outcome measure for randomized controlled trials. We performed a systematic review of treatments tested for pediatric NAFLD, the degree of heterogeneity in trial design, and endpoints analyzed in these studies.

    Methods: We searched publication databases and clinical trial registries through January 7, 2018 for randomized controlled trials (published and underway) of children (<18 years) with NAFLD. Read More

    Rapid response to vedolizumab therapy in biologic-naïve patients with inflammatory bowel diseases.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Department of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
    Background & Aims: Vedolizumab, a humanized monoclonal antibody against α4β7 integrin, is used to treat adults with moderately to severely active ulcerative colitis (UC) and Crohn's disease (CD). We investigated the time course of clinical response to vedolizumab in patients who were and were not previously treated with tumor necrosis factor (TNF) antagonists.

    Methods: We performed a post-hoc analysis of data from phase 3, randomized, controlled trials of vedolizumab vs placebo in adult patients with UC (n=374) or CD (n=784). Read More

    Long-term Efficacy of Interferon-Free Antiviral Treatment Regimens in Patients With Hepatitis C Virus-Associated Cryoglobulinemia Vasculitis.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France.
    Background & Aims: In small-size and short-term studies of hepatitis C virus-associated cryoglobulinemia vasculitis (HCV-CryoVas), patients had a higher rate of response and tolerance to direct-acting antiviral (DAA) agents than interferon-containing regimens. We collected follow-up data from a clinical trial to determine the long-term effectiveness and tolerance of all-oral, interferon-free DAA regimens in patients with CryoVas.

    Methods: We collected follow-up data from a prospective international multi-center cohort study of 148 patients with symptomatic HCV-CryoVas (53. Read More

    Implementation of a Population-Based Cirrhosis Identification and Management System.
    Clin Gastroenterol Hepatol 2018 May 23. Epub 2018 May 23.
    Center for Innovation to Implementation, Palo Alto Veterans Affairs Medical Center, Palo Alto, California; Division of Primary Care and Population Health, Stanford University, Palo Alto, California.

    Measurement of salivary pepsin for diagnosis of GERD in adults and children is not yet ready for clinical application.
    Clin Gastroenterol Hepatol 2018 May 18. Epub 2018 May 18.
    Wingate Institute for Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom. Electronic address:

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