665 results match your criteria Clinical Epidemiology [Journal]


Antidepressants and the risk of traumatic brain injury in the elderly: differences between individual agents.

Clin Epidemiol 2019 15;11:185-196. Epub 2019 Feb 15.

Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany,

Objective: To determine the association of individual antidepressants (ADs) with the risk of traumatic brain injury (TBI) in the elderly.

Patients And Methods: We conducted a case-control study nested in a cohort of new users of ADs aged ≥65 years, identified in the German Pharmacoepidemiological Research Database during 2005-2014. Cases were patients first hospitalized for TBI. Read More

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http://dx.doi.org/10.2147/CLEP.S173667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386209PMC
February 2019

Randomized clinical trials with run-in periods: frequency, characteristics and reporting.

Clin Epidemiol 2019 11;11:169-184. Epub 2019 Feb 11.

Centre for Evidence-Based Medicine Odense (CEBMO), Odense University Hospital, Odense, Denmark,

Background: Run-in periods are occasionally used in randomized clinical trials to exclude patients after inclusion, but before randomization. In theory, run-in periods increase the probability of detecting a potential treatment effect, at the cost of possibly affecting external and internal validity. Adequate reporting of exclusions during the run-in period is a prerequisite for judging the risk of compromised validity. Read More

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http://dx.doi.org/10.2147/CLEP.S188752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377048PMC
February 2019

Health indicator recording in UK primary care electronic health records: key implications for handling missing data.

Clin Epidemiol 2019 11;11:157-167. Epub 2019 Feb 11.

Department of Primary Care and Population Health, University College London, London NW3 2PF, UK,

Background: Clinical databases are increasingly used for health research; many of them capture information on common health indicators including height, weight, blood pressure, cholesterol level, smoking status, and alcohol consumption. However, these are often not recorded on a regular basis; missing data are ubiquitous. We described the recording of health indicators in UK primary care and evaluated key implications for handling missing data. Read More

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https://www.dovepress.com/health-indicator-recording-in-uk-p
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http://dx.doi.org/10.2147/CLEP.S191437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377050PMC
February 2019
2 Reads

The internal validation of weight and weight change coding using weight measurement data within the UK primary care Electronic Health Record.

Clin Epidemiol 2019 25;11:145-155. Epub 2019 Jan 25.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX26GG, UK,

Purpose: To use recorded weight values to internally validate weight status and weight change coding in the primary care Electronic Health Record (EHR).

Patients And Methods: We included adult patients with weight-related Read codes recorded in the UK's Clinical Practice Research Datalink EHR between 2000 and 2017. Weight status codes were compared to weight values recorded on the same day and positive predictive values (PPVs) were calculated for commonly used codes. Read More

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http://dx.doi.org/10.2147/CLEP.S189989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354686PMC
January 2019

Exposure to antimuscarinic medications for treatment of overactive bladder and risk of lung cancer and colon cancer.

Clin Epidemiol 2019 23;11:133-143. Epub 2019 Jan 23.

Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institute, Solna, Sweden,

Introduction: One out of six adults has symptoms of overactive bladder (OAB). Antimuscarinic medication is the main pharmacological group used in the treatment of OAB. In preclinical studies, antimuscarinic compounds have been found to inhibit cell proliferation in lung cancer and colon cancer. Read More

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http://dx.doi.org/10.2147/CLEP.S186842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350836PMC
January 2019

Random error units, extension of a novel method to express random error in epidemiological studies.

Clin Epidemiol 2019 23;11:127-132. Epub 2019 Jan 23.

Department of Public Health Sciences, Karolinska Insitutet, Stockholm, Sweden.

Currently used methods to express random error are often misinterpreted and consequently misused by biomedical researchers. Previously we proposed a simple approach to quantify the amount of random error in epidemiological studies using OR for binary exposures. Expressing random error with the number of random error units (REU) does not require solid background in statistics for a proper interpretation and cannot be misused for making oversimplistic interpretations relying on statistical significance. Read More

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http://dx.doi.org/10.2147/CLEP.S184231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350827PMC
January 2019

Recognizing the role of psychiatric comorbidities: a response to the Danish Colorectal Screening Program.

Clin Epidemiol 2019 23;11:125-126. Epub 2019 Jan 23.

Faculty of Medicine, St George's Hospital Medical School, London, UK,

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http://dx.doi.org/10.2147/CLEP.S198098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350829PMC
January 2019

Validity of first-time diagnoses of congenital epidermolysis bullosa in the Danish National Patient Registry and the Danish Pathology Registry.

Clin Epidemiol 2019 17;11:115-124. Epub 2019 Jan 17.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark,

Purpose: Congenital epidermolysis bullosa (CEB) is a group of rare monogenic genodermatoses. Phenotypically, the diseases vary in both severity and dissemination, which complicates studies of their epidemiology. To investigate the potential of using the Danish National Patient Registry (DNPR) for epidemiological research on CEB, we examined the positive predictive value (PPV) of a first-time diagnosis of CEB. Read More

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http://dx.doi.org/10.2147/CLEP.S184742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340365PMC
January 2019

Cohort profile: ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden).

Clin Epidemiol 2019 14;11:101-114. Epub 2019 Jan 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,

The ESPRESSO study constitutes a novel approach to examine the etiology and prognosis of gastrointestinal disease in which histopathology plays a prominent role. Between 2015 and 2017, all pathology departments (n=28) in Sweden were contacted and asked to procure histopathology record data from the gastrointestinal tract (pharynx to anus), liver, gallbladder, and pancreas. For each individual, local histopathology IT personnel retrieved data on personal identity number, date of histopathology, topography (where the biopsy is taken), morphology (biopsy appearance), and where available free text. Read More

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https://www.dovepress.com/cohort-profile-espresso-epidemiolo
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http://dx.doi.org/10.2147/CLEP.S191914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336132PMC
January 2019
4 Reads

Completeness of testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study.

Clin Epidemiol 2019 10;11:93-99. Epub 2019 Jan 10.

Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark,

Background: The completeness of arranged during ransfection () testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending testing in all MTC patients, improved completeness in Denmark. Read More

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http://dx.doi.org/10.2147/CLEP.S183268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330966PMC
January 2019
1 Read

Central nervous system tumor registration in the Swedish Cancer Register and Inpatient Register between 1990 and 2014.

Clin Epidemiol 2019 4;11:81-92. Epub 2019 Jan 4.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,

Background: The Swedish Cancer Register (SCR) is characterized by excellent quality and completeness overall, but the quality of the reporting may vary according to tumor site and age, and may change over time. The aim of the current study was to investigate the completeness of the reporting of central nervous system (CNS) tumor cases to the SCR.

Materials And Methods: Individuals hospitalized for a CNS tumor between 1990 and 2014 were identified using the Inpatient Register; the proportion of identified cases that did not have any cancer diagnosis reported to the SCR was subsequently assessed. Read More

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https://www.dovepress.com/central-nervous-system-tumor-regis
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http://dx.doi.org/10.2147/CLEP.S177683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324922PMC
January 2019
6 Reads

Benchmarking Danish hospitals on mortality and readmission rates after cardiovascular admission.

Clin Epidemiol 2019 4;11:67-80. Epub 2019 Jan 4.

Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: The aim of this study was to examine hospital performance measures that account more comprehensively for unique mixes of patients' characteristics.

Design: Nationwide cohort registry-based study within a population-based health care system.

Participants: In this study, 331,513 patients discharged with a primary cardiovascular diagnosis from 1 of 26 Danish hospitals during 2011-2015 were included. Read More

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https://www.dovepress.com/benchmarking-danish-hospitals-on-m
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http://dx.doi.org/10.2147/CLEP.S189263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324920PMC
January 2019
5 Reads

Summarizing and communicating on survival data according to the audience: a tutorial on different measures illustrated with population-based cancer registry data.

Clin Epidemiol 2019 3;11:53-65. Epub 2019 Jan 3.

Cancer Survival Group, Department of Non-Communicable DiseaseEpidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK,

Survival data analysis results are usually communicated through the overall survival probability. Alternative measures provide additional insights and may help in communicating the results to a wider audience. We describe these alternative measures in two data settings, the overall survival setting and the relative survival setting, the latter corresponding to the particular competing risk setting in which the cause of death is unavailable or unreliable. Read More

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http://dx.doi.org/10.2147/CLEP.S173523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322561PMC
January 2019
4 Reads

Inhospital death is a biased measure of fatal outcome from bloodstream infection.

Clin Epidemiol 2019 4;11:47-52. Epub 2019 Jan 4.

Department of Pathology and Laboratory Medicine, Royal Inland Hospital, Kamloops, BC, Canada.

Purpose: Inhospital death is commonly used as an outcome measure. However, it may be a biased measure of overall fatal outcome. The objective of this study was to evaluate inhospital death as a measure of all-cause 30-day case fatality in patients with bloodstream infection (BSI). Read More

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http://dx.doi.org/10.2147/CLEP.S187381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324921PMC
January 2019
7 Reads

Very hot tea drinking increases esophageal squamous cell carcinoma risk in a high-risk area of China: a population-based case-control study.

Clin Epidemiol 2019 28;11:43-46. Epub 2018 Dec 28.

Department of Community Medicine, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates,

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http://dx.doi.org/10.2147/CLEP.S192292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314311PMC
December 2018
1 Read

Observational studies of treatment effectiveness: worthwhile or worthless?

Clin Epidemiol 2019 18;11:35-42. Epub 2018 Dec 18.

Department of Primary Care and Population Health, University College London, London, UK,

Observational studies which evaluate effectiveness are often viewed with skepticism owing to the fact that patients are not randomized to treatment, meaning that results are more prone to bias. Therefore, randomized controlled trials remain the gold standard for evaluating treatment effectiveness. However, it is not always possible to conduct randomized trials. Read More

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http://dx.doi.org/10.2147/CLEP.S178723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302806PMC
December 2018
1 Read

Anxiety and depression in patients with Philadelphia-negative myeloproliferative neoplasms: a nationwide population-based survey in Denmark.

Clin Epidemiol 2019 18;11:23-33. Epub 2018 Dec 18.

Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, University of Southern Denmark, Nyborg, Denmark.

Objective: We sought to determine the prevalence and severity of anxiety and depression among patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) and respective associations of anxiety and depression with demographic and lifestyle factors, comorbidity burden, duration of MPN disease, financial difficulties, and health-related quality of life (QoL).

Methods: This study used data from a nationwide, population-based, cross-sectional survey of health-related QoL in MPN patients in Denmark called the MPNhealthSurvey. Individuals with a diagnosis of MPN in the National Patient Register were invited. Read More

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https://www.dovepress.com/anxiety-and-depression-in-patients
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http://dx.doi.org/10.2147/CLEP.S162688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302798PMC
December 2018
8 Reads

Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.

Clin Epidemiol 2019 18;11:17-22. Epub 2018 Dec 18.

GRECC, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA,

Background: Previous studies have shown a link between increased dietary intake of arachidonic acid (ARA) and colorectal neoplasms. It has been shown that erythrocyte phospholipid membrane concentrations of ARA are strongly determined by genetic variation. Fatty acid desaturase (FADS) controls the rate limiting step in ARA production, and FADS variant rs174537 has been shown to be responsible for up to 18. Read More

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https://www.dovepress.com/arachidonic-acid-and-colorectal-ad
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http://dx.doi.org/10.2147/CLEP.S186883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302799PMC
December 2018
8 Reads

Measuring prevalence and incidence of chronic conditions in claims and electronic health record databases.

Clin Epidemiol 2019 17;11:1-15. Epub 2018 Dec 17.

Aetion, Inc, New York, NY, USA,

Background: Health care databases are natural sources for estimating prevalence and incidence of chronic conditions, but substantial variation in estimates limits their interpretability and utility. We evaluated the effects of design choices when estimating prevalence and incidence in claims and electronic health record databases.

Methods: Prevalence and incidence for five chronic diseases at increasing levels of expected frequencies, from cystic fibrosis to COPD, were estimated in the Clinical Practice Research Datalink (CPRD) and MarketScan databases from 2011 to 2014. Read More

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https://www.dovepress.com/measuring-prevalence-and-incidence
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http://dx.doi.org/10.2147/CLEP.S181242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301730PMC
December 2018
18 Reads

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach.

Clin Epidemiol 2018 14;10:1869-1877. Epub 2018 Dec 14.

Health Statistics Group, University of Exeter Medical School, Exeter, UK,

Objective: Precision medicine drug therapy seeks to maximize efficacy and minimize harm for individual patients. This will be difficult if drug response and side effects are positively associated, meaning that patients likely to respond best are at increased risk of side effects. We applied joint longitudinal-survival models to evaluate associations between drug response (longitudinal outcome) and the risk of side effects (survival outcome) for patients initiating type 2 diabetes therapy. Read More

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http://dx.doi.org/10.2147/CLEP.S179555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298877PMC
December 2018
1 Read

Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030.

Authors:
István Kenessey

Clin Epidemiol 2018 13;10:1865-1868. Epub 2018 Dec 13.

National Cancer Registry of Hungary, National Institute of Oncology, Budapest, Hungary,

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http://dx.doi.org/10.2147/CLEP.S195330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296688PMC
December 2018
1 Read

Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study.

Clin Epidemiol 2018 12;10:1851-1864. Epub 2018 Dec 12.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK,

Background: Infants with atopic eczema have an increased risk of impaired growth, but the origin of this impairment is unclear. The aim of this study was to examine fetal and infant growth in relation to infantile atopic eczema.

Methods: Within the UK Southampton Women's Survey, 1,759 infants with known maternal menstrual data had anthropometric measurements at 11, 19, and 34 weeks' gestation, birth, and ages 6 and 12 months, enabling derivation of growth velocity SD scores. Read More

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http://dx.doi.org/10.2147/CLEP.S175878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296686PMC
December 2018
1 Read

Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns.

Clin Epidemiol 2018 3;10:1801-1816. Epub 2018 Dec 3.

Pharmacoepidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, 0316 Oslo, Norway,

Purpose: A reliable definition of exposure and knowledge about long-term medication patterns is important for drug safety studies during pregnancy. Few studies have investigated these measures for thyroid hormone replacement therapy (THRT). The purpose of this study was to 1) calculate the agreement between self-report and dispensed prescriptions of THRT and 2) classify women with similar adherence patterns to THRT into disjoint longitudinal trajectories. Read More

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https://www.dovepress.com/maternal-use-of-thyroid-hormone-re
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http://dx.doi.org/10.2147/CLEP.S175616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283256PMC
December 2018
14 Reads

The effects of Bu Yang Huan Wu Tang on post-stroke epilepsy: a nationwide matched study.

Clin Epidemiol 2018 10;10:1839-1850. Epub 2018 Dec 10.

School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan,

Objective: To compare the long-term risk of epilepsy in stroke patients who use Bu Yang Huan Wu Tang (BYHWT) and those who do not.

Methods: In the Taiwanese national insurance claims data, we identified newly diagnosed stroke patients receiving inpatient care in the years 2000-2004. Using propensity score-matched pairs to balance the baseline characteristics, we selected eligible stroke patients who did (n=8,971) and did not (n=8,971) receive BYHWT. Read More

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http://dx.doi.org/10.2147/CLEP.S175677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292405PMC
December 2018
2 Reads

Barthel Index at hospital admission is associated with mortality in geriatric patients: a Danish nationwide population-based cohort study.

Clin Epidemiol 2018 27;10:1789-1800. Epub 2018 Nov 27.

Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark,

Purpose: The Barthel Index (BI)-100 is used to measure geriatric patients' activities of daily living (ADL). The aim of this study was to explore whether BI at hospital admission is associated with mortality.

Patients And Methods: In a nationwide population-based cohort study, patients aged ≥65 years admitted during 2005-2014 to Danish geriatric departments were assessed with BI at admission. Read More

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http://dx.doi.org/10.2147/CLEP.S176035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267735PMC
November 2018
1 Read

Erratum: Assessment of channeling bias among initiators of glucose-lowering drugs: A UK cohort study [Corrigendum].

Authors:

Clin Epidemiol 2018 28;10:1787. Epub 2018 Nov 28.

[This corrects the article on p. 19 in vol. 9, PMID: 28176886. Read More

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http://dx.doi.org/10.2147/CLEP.S191335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276818PMC
November 2018
1 Read

Combining distributed regression and propensity scores: a doubly privacy-protecting analytic method for multicenter research.

Clin Epidemiol 2018 27;10:1773-1786. Epub 2018 Nov 27.

Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Purpose: Sharing of detailed individual-level data continues to pose challenges in multi-center studies. This issue can be addressed in part by using analytic methods that require only summary-level information to perform the desired multivariable-adjusted analysis. We examined the feasibility and empirical validity of 1) conducting multivariable-adjusted distributed linear regression and 2) combining distributed linear regression with propensity scores, in a large distributed data network. Read More

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http://dx.doi.org/10.2147/CLEP.S178163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267363PMC
November 2018
1 Read

Pregnancy outcomes in women with autism: a nationwide population-based cohort study.

Clin Epidemiol 2018 30;10:1817-1826. Epub 2018 Nov 30.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: The consequences of autism in pregnancy outcomes have not been explored before, although it is of crucial importance because of the frequent comorbidities and medication in this group of women.

Objectives: To estimate the risk of adverse pregnancy outcomes in women diagnosed with autism.

Design: Nationwide population-based cohort study. Read More

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https://www.dovepress.com/pregnancy-outcomes-in-women-with-a
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http://dx.doi.org/10.2147/CLEP.S176910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280895PMC
November 2018
12 Reads

Labor augmentation during birth and later cognitive ability in young adulthood.

Clin Epidemiol 2018 26;10:1765-1772. Epub 2018 Nov 26.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark,

Purpose: Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods.

Patients And Methods: We identified 330,107 individuals (96. Read More

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http://dx.doi.org/10.2147/CLEP.S181012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263242PMC
November 2018
2 Reads

A validated algorithm to identify recurrence of bladder cancer: a register-based study in Denmark.

Clin Epidemiol 2018 26;10:1755-1763. Epub 2018 Nov 26.

Research Centre for Cancer Diagnosis in Primary Care (CaP), Research Unit for General Practice, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark,

Purpose: Recurrence of cancer is not routinely registered in the national registers in Denmark. The aim of this study was to develop and validate a register-based algorithm to identify patients diagnosed with recurrence of invasive bladder cancer (BC).

Materials And Methods: We performed a cohort study based on data from Danish national health registers. Read More

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http://dx.doi.org/10.2147/CLEP.S177305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263214PMC
November 2018
1 Read

Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 6,724 patients with 2 years follow-up.

Clin Epidemiol 2018 23;10:1743-1753. Epub 2018 Nov 23.

Population Health and Genomics, School of Medicine, University of Dundee, Dundee DD2 4BF, UK,

Purpose: Cognitive impairment is common in older people admitted to hospital, but the outcomes are generally poorly understood, and previous research has shown inconsistent associations with mortality depending on the type of cognitive impairment examined and duration of follow-up. This study examines mortality in older people with any cognitive impairment during acute hospital admission.

Patients And Methods: Prospective cohort of 6,724 people aged ≥65 years with a structured cognitive assessment on acute admission were included in this study. Read More

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http://dx.doi.org/10.2147/CLEP.S174807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257080PMC
November 2018
2 Reads

Demographic and comorbidity predictors of adherence to diagnostic colonoscopy in the Danish Colorectal Cancer Screening Program: a nationwide cross-sectional study.

Clin Epidemiol 2018 23;10:1733-1742. Epub 2018 Nov 23.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark,

Background: Predictors of participation in colorectal cancer screening with a stool sample screening modality have been widely studied, but adherence to subsequent diagnostic colonoscopy after a positive screening test has received less attention. We aimed to determine predictors of adherence to diagnostic colonoscopy in the Danish Colorectal Cancer Screening Program.

Methods: We conducted a cross-sectional study using data from National Health Service registries. Read More

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http://dx.doi.org/10.2147/CLEP.S176923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257139PMC
November 2018
1 Read

School performance in children with infantile hydrocephalus: a nationwide cohort study.

Clin Epidemiol 2018 22;10:1721-1731. Epub 2018 Nov 22.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark,

Purpose: Little is known about the prognosis for school performance among children with all-cause infantile hydrocephalus (IHC). Using detailed educational data, we investigated the school performance for IHC patients compared to other children in Denmark.

Patients And Methods: We conducted a population-based cohort study of all live-born children in Denmark (1977-2015) based on data from the Danish national health registers and the Danish educational register. Read More

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http://dx.doi.org/10.2147/CLEP.S178757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254655PMC
November 2018
5 Reads

Positive predictive value of first-time rheumatoid arthritis diagnoses and their serological subtypes in the Danish National Patient Registry.

Clin Epidemiol 2018 21;10:1709-1720. Epub 2018 Nov 21.

Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark,

Purposes: To assess whether the positive predictive value (PPV) of first-time rheumatoid arthritis (RA) diagnosis registration in the Danish National Patient Registry increases when data are linked to the RA treatment codes and to assess the PPV of first-time RA diagnoses according to RA serological subtypes.

Methods: Participants from the Danish Diet, Cancer, and Health cohort with at least one RA diagnosis, registered at one of the Central Denmark Region hospitals in the Danish National Patient Registry during the period 1977-2016, were identified. Register-based RA diagnoses were verified by scrutinizing medical records against RA classification criteria or clinical case RA. Read More

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http://dx.doi.org/10.2147/CLEP.S175406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254991PMC
November 2018
2 Reads

Determinants of sporadic infections in Denmark: a nationwide case-control study among children and young adults.

Clin Epidemiol 2018 21;10:1695-1707. Epub 2018 Nov 21.

Infectious Disease Epidemiology & Prevention, Statens Serum Institut, Copenhagen, Denmark,

Background: Each year more than 4,000 cases of campylobacteriosis are reported in Denmark, making it the most common bacterial gastrointestinal infection. Here we describe a case-control study to identify sources of infection with a focus on environmental factors.

Methods: From January to December 2016, we conducted a prospective case-control study among Danish persons aged 1-30 years. Read More

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http://dx.doi.org/10.2147/CLEP.S177141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255050PMC
November 2018
1 Read

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records.

Clin Epidemiol 2018 16;10:1679-1693. Epub 2018 Nov 16.

Aging Research Center, Karolinska Institutet, Stockholm, Sweden,

Background: The continuous growth of the current dementia epidemic is contingent on the stability of age- and sex-specific trends over time. However, recent evidence suggests declining or stable trends. The aim of this study was to evaluate the real-world changes in the burden of dementia in older adults in Sweden from 1987 to 2016 by estimating age- and sex-specific incidence of dementia diagnosis in hospital inpatient records (dementia incidence). Read More

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http://dx.doi.org/10.2147/CLEP.S178955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247947PMC
November 2018
1 Read

How well can familial hypercholesterolemia be identified in an electronic health record database?

Clin Epidemiol 2018 15;10:1667-1677. Epub 2018 Nov 15.

Practice Fusion, San Francisco, CA, USA.

Background: Familial hypercholesterolemia (FH) is a condition characterized by high cholesterol levels and increased risk for coronary heart disease (CHD) that often goes undiagnosed. The Dutch Lipid Network Criteria (DLNC) are used to identify FH in clinical settings via physical examination, personal and family history of CHD, in addition to the presence of deleterious mutations of the , , and genes. Agreement between clinical and genetic diagnosis of FH varies. Read More

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http://dx.doi.org/10.2147/CLEP.S176853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241698PMC
November 2018
2 Reads

Overuse of methylphenidate: an analysis of Swedish pharmacy dispensing data.

Clin Epidemiol 2018 9;10:1657-1665. Epub 2018 Nov 9.

Department of Clinical Sciences, Unit for Social Epidemiology, Faculty of Medicine, Lund University, Malmö, Sweden,

Purpose: To identify overuse of methylphenidate and to investigate patterns of overuse in relation to sociodemographic and clinical characteristics.

Patients And Methods: Swedish national, pharmacy dispensing data were analyzed for all 56,922 individuals aged 6-79 years, who filled a methylphenidate prescription between 2010 and 2011. Overuse was defined as having above 150% days covered by the dispensed amount during 365 days from the first prescription fill, assuming use at the maximum recommended daily dose. Read More

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http://dx.doi.org/10.2147/CLEP.S178638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233857PMC
November 2018
3 Reads

Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program.

Clin Epidemiol 2018 13;10:1649-1655. Epub 2018 Nov 13.

Department of Digestive Diseases K, Bispebjerg Hospital, Copenhagen, Denmark.

Background: The Danish national screening program for colorectal cancer (CRC) consists of an immunochemical fecal occult blood test (iFOBT) followed by colonoscopy. The Danish Colorectal Cancer Screening Database (DCCSD) records data on the incidence of hospital-registered complications after colonoscopy. However, the validity of these data is unknown, and the incidence of complications is potentially underreported. Read More

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http://dx.doi.org/10.2147/CLEP.S181204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239110PMC
November 2018
3 Reads

Factors associated with choice of intensification treatment for type 2 diabetes after metformin monotherapy: a cohort study in UK primary care.

Clin Epidemiol 2018 8;10:1639-1648. Epub 2018 Nov 8.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK,

Purpose: To understand the patient characteristics associated with treatment choice at the first treatment intensification for type 2 diabetes.

Patients And Methods: This is a noninterventional study, using UK electronic primary care records from the Clinical Practice Research Datalink. We included adults treated with metformin monotherapy between January 2000 and July 2017. Read More

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http://dx.doi.org/10.2147/CLEP.S176142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233860PMC
November 2018
1 Read

Fall injuries, associated deaths, and 30-day readmission for subsequent falls are increasing in the elderly US population: a query of the WHO mortality database and National Readmission Database from 2010 to 2014.

Clin Epidemiol 2018 8;10:1627-1637. Epub 2018 Nov 8.

Acute Care Surgery Division, Department of Surgery, Iowa City, IA, USA,

Purpose: Clinicians anecdotally noted that elderly patients who suffered from traumatic injuries (falls or other injuries) often re-present and are readmitted with fall injuries. Herein, we hypothesized that fall injuries and fall-related deaths and readmissions are increasing over time, and assessed whether the overall rates of death, hospital admission, and 30-day readmission due to falls increased from 2010 to 2014 in the elderly population (≥65) in the US.

Patients And Methods: The WHO mortality database and the National Readmission Database (NRD) were queried to assess rates of deaths and hospital admissions and 30-day readmissions associated with fall injuries in the elderly population that presented with trauma. Read More

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http://dx.doi.org/10.2147/CLEP.S181138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233862PMC
November 2018
2 Reads

Rural and urban disparities in the care of Canadian patients with inflammatory bowel disease: a population-based study.

Clin Epidemiol 2018 8;10:1613-1626. Epub 2018 Nov 8.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background And Aims: Canada's large geographic area and low population density pose challenges in access to specialized health care for remote and rural residents. We compared health services use, surgical rate, and specialist gastroenterologist care in rural and urban inflammatory bowel disease (IBD) patients in Canada.

Methods: We used validated algorithms that were applied to population-based health administrative data to identify all people living with the following three Canadian provinces: Alberta, Manitoba, and Ontario (ON). Read More

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http://dx.doi.org/10.2147/CLEP.S178056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233859PMC
November 2018
6 Reads

Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring.

Clin Epidemiol 2018 1;10:1599-1612. Epub 2018 Nov 1.

Boston Collaborative Drug Surveillance Program, Boston University School of Public Health, Lexington, MA 02421, USA,

Background: Results of some studies suggest that prenatal antidepressant exposure increases the risk of autism spectrum disorder (ASD) in offspring, while other studies suggest that depression independently increases the risk of having a child with ASD. Thus, confounding by indication is a concern.

Objective: The aim of this study was to estimate the risk of ASD in offspring of women who were exposed to antidepressants and/or had depression during pregnancy compared to unexposed women. Read More

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http://dx.doi.org/10.2147/CLEP.S180618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219268PMC
November 2018
19 Reads

Short- and long-term outcomes after postsurgical acute kidney injury requiring dialysis.

Clin Epidemiol 2018 26;10:1583-1598. Epub 2018 Oct 26.

Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan,

Objective: Prompt assessment of perioperative complications is critical for the comprehensive care of surgical patients. Acute kidney injury requiring dialysis (AKI-D) is associated with high mortality, yet little is known about how long-term outcomes of patients have evolved. The association of AKI-D with postsurgical outcomes has not been well studied. Read More

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http://dx.doi.org/10.2147/CLEP.S169302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208534PMC
October 2018
15 Reads

Oral metronidazole use and risk of acute pancreatitis: a population-based case-control study.

Clin Epidemiol 2018 25;10:1573-1581. Epub 2018 Oct 25.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,

Objective: Oral metronidazole used in combined regimens for eradication has been associated with an increased risk of acute pancreatitis; however, it is less clear whether a similar association exists for single-regimen metronidazole. We, therefore, examined the association of single and combined regimens of oral metronidazole with risk of acute pancreatitis.

Methods: In this population-based case-control study, all individuals in Sweden (aged 40-84 years) hospitalized with acute pancreatitis between January 2006 and December 2008 were identified from a national hospital register (n=5,996). Read More

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http://dx.doi.org/10.2147/CLEP.S159702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208546PMC
October 2018
15 Reads

Association between educational level and cardiovascular disease and all-cause mortality in patients with type 2 diabetes: a prospective study in the Joint Asia Diabetes Evaluation Program.

Clin Epidemiol 2018 25;10:1561-1571. Epub 2018 Oct 25.

Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China,

Purpose: The aim of this study was to describe the association between educational level and incident cardiovascular disease (CVD) and all-cause mortality in Hong Kong Chinese patients with type 2 diabetes.

Patients And Methods: We included 12,634 patients with type 2 diabetes who were enrolled into the Joint Asia Diabetes Evaluation Program between June 1, 2007, and June 30, 2017. We classified patients' educational level into the following three groups: ≤6 years, 6-13 years, and >13 years. Read More

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http://dx.doi.org/10.2147/CLEP.S177437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208565PMC
October 2018
8 Reads

Development and validation of a risk prediction model for severe hypoglycemia in adult patients with type 2 diabetes: a nationwide population-based cohort study.

Clin Epidemiol 2018 23;10:1545-1559. Epub 2018 Oct 23.

Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea,

Purpose: There is a scarcity of long-term prediction models for severe hypoglycemia (SH) in subjects with type 2 diabetes mellitus (T2DM). In this study, a model was developed and validated to predict the risk of SH in adult patients with T2DM.

Patients And Methods: Baseline and follow-up data from patients with T2DM who received health evaluations from January 1, 2009, to December 31, 2010 (n=1,676,885) were analyzed as development (n=1,173,820) and validation (n=503,065) cohorts using the National Health Insurance Database (DB) in Korea. Read More

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https://www.dovepress.com/development-and-validation-of-a-ri
Publisher Site
http://dx.doi.org/10.2147/CLEP.S169835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203120PMC
October 2018
9 Reads

Does low risk of infections as a marker of effective immunity predict increased risk of subsequent giant cell arteritis or polymyalgia rheumatica? A Danish population-based case-control study.

Clin Epidemiol 2018 16;10:1533-1543. Epub 2018 Oct 16.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark,

Objective: It has been suggested that a hyper-effective immune system ("hyper-immunity") is central to the pathogenesis of giant cell arteritis and polymyalgia rheumatica (GCA/PMR). We examined if a low risk of infections, as a marker of hyper-immunity, can predict increased subsequent risk of GCA/PMR.

Patients And Methods: We conducted a population-based case-control study including all patients aged ≥50 years with incident GCA/PMR diagnosed between 1997 and 2012 in Northern Denmark. Read More

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https://www.dovepress.com/does-low-risk-of-infections-as-a-m
Publisher Site
http://dx.doi.org/10.2147/CLEP.S158293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201992PMC
October 2018
14 Reads

Comparing causes of death of Hodgkin lymphoma and breast cancer patients between medical records and cause-of-death statistics.

Clin Epidemiol 2018 16;10:1523-1531. Epub 2018 Oct 16.

Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands,

Objective: Obtaining accurate data about causes of death may be difficult in patients with a complicated disease history, including cancer survivors. This study compared causes of death derived from medical records (COD) with causes of death derived from death certificates (COD) as processed by Statistics Netherlands of patients primarily treated for Hodgkin lymphoma (HL) or breast cancer (BC).

Methods: Two hospital-based cohorts comprising 1,215 HL patients who died in the period 1980-2013 and 714 BC patients who died in the period 2000-2013 were linked with cause-of-death statistics files. Read More

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http://dx.doi.org/10.2147/CLEP.S161359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202004PMC
October 2018
3 Reads