544 results match your criteria Clinical Epidemiology [Journal]
Clin Epidemiol 2018 7;10:671-681. Epub 2018 Jun 7.
The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Background: Before embarking on administrative research, validated case ascertainment algorithms must be developed. We aimed at developing algorithms for identifying inflammatory bowel disease (IBD) patients, date of disease onset, and IBD type (Crohn's disease [CD] vs ulcerative colitis [UC]) in the databases of the four Israeli Health Maintenance Organizations (HMOs) covering 98% of the population.
Methods: Algorithms were developed on 5,131 IBD patients and 2,072 controls, following independent chart review (60% CD and 39% UC). Read More
Clin Epidemiol 2018 6;10:655-669. Epub 2018 Jun 6.
PharmacoEpidemiology and Drug Safety Research Group, School of Pharmacy and PharmaTox Strategic Research Initiative, University of Oslo, Oslo, Norway.
Purpose: This study aimed at exploring the prevalence of self-reported antenatal and postnatal depressive symptoms by severity across multiple countries and the association between antidepressant treatment in pregnancy and postnatal symptom severity.
Materials And Methods: This was a multinational web-based study conducted across 12 European countries (n=8069). Uniform data collection was ensured via an electronic questionnaire. Read More
Clin Epidemiol 2018 5;10:643-654. Epub 2018 Jun 5.
Centre for Statistics in Medicine, Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Background: Missing data are often an issue in electronic medical records (EMRs) research. However, there are many ways that people deal with missing data in drug safety studies.
Aim: To compare the risk estimates resulting from different strategies for the handling of missing data in the study of venous thromboembolism (VTE) risk associated with antiosteoporotic medications (AOM). Read More
Clin Epidemiol 2018 30;10:631-641. Epub 2018 May 30.
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Background: Individuals with a family history of Parkinson's disease (PD) appear to have a higher risk of developing PD and other neuropsychiatric diseases. However, estimates of the relative risks (RRs) of PD and the roles of genetic and environmental factors in PD susceptibility are unclear. The aim of this study was to examine familial aggregation and genetic contributions to PD and the RRs of other neuropsychiatric diseases in relatives of PD patients. Read More
Clin Epidemiol 2018 29;10:623-630. Epub 2018 May 29.
Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Purpose: A post hoc analysis of a recent trial on direct oral anticoagulants versus vitamin K antagonists showed that amongst patients with mildly decreased kidney function, use of vitamin K antagonists was associated with a greater decline in renal function than use of direct oral anticoagulants. Whether these vitamin K antagonist effects are the same in pre-dialysis patients is unknown. Therefore, the aim of this study was to investigate the association between vitamin K antagonist use and the rate of renal function decline and time until start of dialysis in incident pre-dialysis patients. Read More
Clin Epidemiol 2018 25;10:613-622. Epub 2018 May 25.
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Purpose: Substantial heterogeneity exists in reported kidney function decline in pre-dialysis chronic kidney disease (CKD). By design, kidney function decline can be studied in CKD 3-5 cohorts or dialysis-based studies. In the latter, patients are selected based on the fact that they initiated dialysis, possibly leading to an overestimation of the true underlying kidney function decline in the pre-dialysis period. Read More
Clin Epidemiol 2018 25;10:605-612. Epub 2018 May 25.
Section of Metabolic Genetics and Section of Epidemiology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Background: Excess body weight in adulthood is associated with risk for asthma admission (AA). Our aim was to investigate if this association also applies to the relation between body mass index (BMI) in childhood and AAs in early adulthood (age 20-45 years).
Methods: This was a prospective study of 310,211 schoolchildren (born 1930-1989) from the Copenhagen School Health Records Register. Read More
Clin Epidemiol 2018 24;10:593-604. Epub 2018 May 24.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Background: A parental cancer diagnosis is a stressful life event, potentially leading to increased risks of mental and physical problems among children. This study aimed to investigate the associations of parental cancer with IQ, stress resilience, and physical fitness of the affected men during early adulthood.
Materials And Methods: In this Swedish population-based study, we included 465,249 men born during 1973-1983 who underwent the military conscription examination around the age of 18 years. Read More
Clin Epidemiol 2018 25;10:581-591. Epub 2018 May 25.
Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs) after diagnosis, expected years of life lost (EYLL), and lifetime health care expenditures for 19 major cancers in Taiwan.
Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. Read More
Clin Epidemiol 2018 21;10:575-579. Epub 2018 May 21.
Analysis Group, Inc., Boston, MA, USA.
Background: When an exclusionary criterion is an imperfect screen, some ineligible patients will remain in a study. Medical record review for outcome adjudication can reveal such individuals.
Objective: To ascertain the circumstances under which it is advisable to remove outcome cases first found to be ineligible on chart review. Read More
Clin Epidemiol 2018 17;10:561-573. Epub 2018 May 17.
Department of Biostatistics and Bioinformatics, Hospices Civils de Lyon, Lyon, France.
Background: Describing the relationship between socioeconomic inequalities and cancer survival is important but methodologically challenging. We propose guidelines for addressing these challenges and illustrate their implementation on French population-based data.
Methods: We analyzed 17 cancers. Read More
Clin Epidemiol 2018 10;10:549-560. Epub 2018 May 10.
Cardiovascular Epidemiology and Genetics Research Group, IMIM-Hospital del Mar Research Institute.
Background: The validity of a cardiovascular risk self-screening method was assessed. The results obtained for self-measurement of blood pressure, a point-of-care system's assessment of lipid profile and glycated hemoglobin, and a self-administered questionnaire (sex, age, diabetes, tobacco consumption) were compared with the standard screening (gold standard) conducted by a health professional.
Methods: Crossover clinical trial on a population-based sample from Girona (north-eastern Spain), aged 35-74, with no cardiovascular disease at recruitment. Read More
Clin Epidemiol 2018 9;10:537-548. Epub 2018 May 9.
Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Purpose: The purpose of this study was to examine why Norway has the highest rate of mortality due to cutaneous melanoma (CM) in Europe. The Norwegian Malignant Melanoma Registry (NMMR) enables the study of clinical and histopathological characteristics of patients who die due to CM.
Results: The NMMR and the Norwegian Cause of Death Registry provided data on the clinical and histopathological factors as well as the date and cause of death, through June 2015 for all first invasive CMs diagnosed in 2008-2012 (n=8087). Read More
Clin Epidemiol 2018 8;10:531-535. Epub 2018 May 8.
Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany.
Background: Results of randomized controlled trials (RCTs) are usually accompanied by a table that compares covariates between the study groups at baseline. Sometimes, the investigators report values for imbalanced covariates. The aim of this debate is to illustrate the pro and contra of the use of these values in RCTs. Read More
Clin Epidemiol 2018 7;10:521-530. Epub 2018 May 7.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Background: Histamine H receptor activation promotes cardiac fibrosis and apoptosis in mice. However, the potential effectiveness of histamine H receptor antagonists (H2RAs) in humans with heart failure is largely unknown. We examined the association between H2RA initiation and all-cause mortality among patients with heart failure. Read More
Clin Epidemiol 2018 1;10:511-519. Epub 2018 May 1.
Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Purpose: Individuals with cerebral palsy (CP) are at increased risk for frailty and chronic disease due to factors experienced throughout the lifespan, such as excessive sedentary behaviors and malnutrition. However, little is known about noncommunicable diseases (NCDs) and multimorbidity profiles in young adults with CP. The study objective was to compare NCD and multimorbidity profiles between young adults with and without CP. Read More
Clin Epidemiol 2018 30;10:499-509. Epub 2018 Apr 30.
Institute of Health Services Research and Health Economics, German Diabetes Center, Düsseldorf, Germany.
Aims: Patients with diabetes are probably often unaware of their comorbidities. We estimated agreement between self-reported comorbidities and administrative data.
Methods: In a random sample of 464 diabetes patients, data from a questionnaire asking about the presence of 14 comorbidities closely related to diabetes were individually linked with statutory health insurance data. Read More
Clin Epidemiol 2018 27;10:489-497. Epub 2018 Apr 27.
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Characterizing the relations between exposures and diseases is the central tenet of epidemiology. Researchers may want to evaluate exposure-disease causation by assessing whether the disease under concern is induced by the various exposures - the so-called "attribution". In this paper, the authors propose a method to attribute diseases to multiple pathways based on the causal-pie model. Read More
Clin Epidemiol 2018 20;10:475-488. Epub 2018 Apr 20.
Institute for Health Services Research and Health Economics, German Diabetes Center (DDZ) Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Background And Purpose: Lower-extremity amputations (LEAs) in people with diabetes are associated with reduced quality of life and increased health care costs. Detailed knowledge on amputation rates (ARs) is of utmost importance for future health care and economics strategies. We conducted the present cohort study in order to estimate the incidences of LEA as well as relative and attributable risk due to diabetes and to investigate time trends for the period 2008-2012. Read More
Clin Epidemiol 2018 18;10:457-474. Epub 2018 Apr 18.
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
Objective: Physicians commonly prescribe antidepressants for indications other than depression that are not evidence-based and need further evaluation. However, lack of routinely documented treatment indications for medications in administrative and medical databases creates a major barrier to evaluating antidepressant use for indications besides depression. Thus, the aim of this study was to derive a model to predict when primary care physicians prescribe antidepressants for indications other than depression and to identify important determinants of this prescribing practice. Read More
Clin Epidemiol 2018 18;10:445-456. Epub 2018 Apr 18.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Background: Monitoring hospital outcomes and clinical processes as a measure of clinical performance is an integral part of modern health care. The risk-adjusted cumulative sum (CUSUM) chart is a frequently used sequential analysis technique that can be implemented to monitor a wide range of different types of outcomes.
Objective: The aim of this study was to describe how risk-adjusted CUSUM charts based on population-based nationwide medical registers were used to monitor 30-day mortality in Danish hospitals and to give an example on how alarms of increased hospital mortality from the charts can guide further in-depth analyses. Read More
Clin Epidemiol 2018 17;10:431-444. Epub 2018 Apr 17.
Department of Urology, Medical University of Vienna, Vienna, Austria.
Objective: To investigate the impact of moderate wine consumption on the risk of prostate cancer (PCa). We focused on the differential effect of moderate consumption of red versus white wine.
Design: This study was a meta-analysis that includes data from case-control and cohort studies. Read More
Clin Epidemiol 2018 16;10:421-429. Epub 2018 Apr 16.
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Objective: We investigated the burden of chronic kidney disease (CKD) among patients with severe mental illness (SMI).
Methods: We identified patients with SMI among all those aged 25-74 registered in the UK Clinical Practice Research Datalink as on March 31, 2014. We compared the prevalence of CKD (two measurements of estimated glomerular filtration rate <60 mL/min/1. Read More
Clin Epidemiol 2018 13;10:413-419. Epub 2018 Apr 13.
Non-Communicable Diseases and Trauma Direction, The French Public Health Agency, Saint-Maurice, France.
Background: The terrorist attacks in Paris and Nice in 2015 and 2016 generated widespread emotional stress in France. Given that acute emotional stress is a well-known trigger for cardiovascular disease, we investigated whether these attacks had any short-term impact on hospitalizations for acute cardiovascular disease in France.
Methods: Annual hospital discharge data from 2009 to 2016 were extracted from the French Hospital Discharge Database. Read More
Clin Epidemiol 2018 11;10:401-411. Epub 2018 Apr 11.
Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.
Background: Hematology-oncology patients often become severely thrombocytopenic and receive prophylactic platelet transfusions when their platelet count drops below 10×10 platelets/L. This so-called "platelet count trigger" of 10×10 platelets/L is recommended because currently available evidence suggests this is the critical concentration at which bleeding risk starts to increase. Yet, exposure time and lag time may have biased the results of studies on the association between platelet counts and bleeding risks. Read More
Clin Epidemiol 2018 10;10:391-399. Epub 2018 Apr 10.
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Objective: To validate the Danish National Patient Register's (NPR) diagnoses of pediatric acquired demyelinating syndromes (ADS) including multiple sclerosis (MS).
Study Design And Setting: We identified ADS diagnostic groups using International Classification of Diseases (ICD) codes and reviewed medical records to validate the NPR diagnoses during 2008-2015.
Results: Among 409 children in the study, 184 children had a validated and final ADS diagnosis after reviewing medical records as follows: optic neuritis (ON; n=46), transverse myelitis (TM; n=16), acute disseminated encephalomyelitis (ADEM; n=50), clinically isolated syndrome (CIS) including dissemination in space (CIS [DIS]) but not dissemination in time (n=6), neuromyelitis optica spectrum disorder (NMOsd; n=5), and MS (n=61). Read More
Clin Epidemiol 2018 5;10:381-389. Epub 2018 Apr 5.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Objective: Fecal immunochemical tests (FITs) for hemoglobin in stool are increasingly used for colorectal cancer screening. Reported sensitivities and specificities have strongly varied between studies, but it is unclear to what extent such variation reflects differences between tests or between study population characteristics. We aimed to evaluate the key parameters of FIT performance for detecting advanced neoplasia (AN) according to sex and age. Read More
Clin Epidemiol 2018 4;10:363-379. Epub 2018 Apr 4.
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Background: Previous findings suggest that apathy symptoms independently of depressive symptoms measured using the Geriatric Depression Scale (GDS) are associated with cardiovascular disease (CVD) in older individuals.
Aims: To study whether apathy and depressive symptoms in older people are associated with future CVD, stroke, and mortality using individual patient-data meta-analysis.
Methods: Medline, Embase, and PsycInfo databases up to September 3, 2013, were systematically searched without language restrictions. Read More
Clin Epidemiol 2018 29;10:353-362. Epub 2018 Mar 29.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Background: To enhance the utility of transfusion data for research, ideally every transfusion should be linked to a primary clinical indication. In electronic patient records, many diagnostic and procedural codes are registered, but unfortunately, it is usually not specified which one is the reason for transfusion. Therefore, a method is needed to determine the most likely indication for transfusion in an automated way. Read More
Clin Epidemiol 2018 23;10:343-351. Epub 2018 Mar 23.
Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical trials as they allow modifications to key trial design components during the trial, as data is being collected, using preplanned decision rules. Read More
Clin Epidemiol 2018 19;10:333-341. Epub 2018 Mar 19.
Department of Biostatistics, University Medical Center Utrecht, Utrecht, the Netherlands.
Objective: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several strategies for the simultaneous analysis of function and mortality in ALS clinical trials.
Methods: Based on the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database, we simulated longitudinal patterns of functional decline, defined by the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) and conditional survival time. Read More
Clin Epidemiol 2018 19;10:323-332. Epub 2018 Mar 19.
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Purpose: The purpose of this study was to investigate the association between mode of delivery and the risk of celiac disease in two large population-based birth cohorts with different prevalence of diagnosed celiac disease.
Patients And Methods: This is an observational register-based cohort study using two independent population cohorts. We used data from administrative registers and health administrative registers from Denmark and Norway and linked the data at the individual level. Read More
Clin Epidemiol 2018 19;10:311-322. Epub 2018 Mar 19.
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus.
Purpose: Cryptorchidism is the most frequent congenital malformation in boys and is associated with low sperm count, infertility and testicular cancer. Unhealthy maternal lifestyle during pregnancy such as smoking, high prepregnancy body mass index (BMI) as well as alcohol and caffeine intake may constitute possible risk factors for cryptorchidism, but results from the few previous studies are conflicting. We aimed to explore the association between maternal lifestyle factors and occurrence of cryptorchidism in sons. Read More
Clin Epidemiol 2018 9;10:277-288. Epub 2018 Mar 9.
Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Background: In 2012, liver cancer ranked as the fifth and eighth most common cancer in men and women, respectively, in urban Shanghai. This study aims to present the trend and projection of age-specific incidence and mortality of liver cancer in Shanghai.
Methods: We extracted data of liver cancer incident cases and deaths between 1973 and 2012. Read More
Clin Epidemiol 2018 6;10:265-276. Epub 2018 Mar 6.
Division of Medical Informatics and Administration Planning, Kyoto University Hospital, Kyoto.
Background: Acetaminophen (APAP) is frequently used for analgesia and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for the kidneys. However, there is little epidemiological evidence of the association between APAP and acute kidney injury (AKI).
Objectives: To examine the association between APAP and AKI using the self-controlled case series (SCCS) method, which is a novel strategy to control between-person confounders by comparing the risk and reference periods in each patient. Read More
Clin Epidemiol 2018 6;10:253-264. Epub 2018 Mar 6.
Department of Medical Statistics and Centre for Global NCDs, London School of Hygiene and Tropical Medicine, London, UK.
Where do new research questions come from? This is at best only partially taught in courses or textbooks about clinical or epidemiological research. Methods are taught under the assumption that a researcher already knows the research question and knows which methods will fit that question. Similarly, the real complexity of the thought processes that lead to a scientific undertaking is almost never described in published papers. Read More
Clin Epidemiol 2018 6;10:235-251. Epub 2018 Mar 6.
Health Services Research on Chronic Patients Network (REDISSEC), Galdakao, Bizkaia, Spain.
Introduction: Colorectal cancer is one of the most frequently diagnosed malignancies and a common cause of cancer-related mortality. The aim of this study was to develop and validate a clinical predictive model for 1-year mortality among patients with colon cancer who survive for at least 30 days after surgery.
Methods: Patients diagnosed with colon cancer who had surgery for the first time and who survived 30 days after the surgery were selected prospectively. Read More
Clin Epidemiol 2018 13;10:299-310. Epub 2018 Mar 13.
Department of Epidemiology, RTI Health Solutions, Barcelona, Spain.
Background: There is a concern that topical tacrolimus and pimecrolimus, indicated for second-line treatment of atopic dermatitis, may increase the risk of lymphoma and skin cancer, particularly in children.
Objective: The aim of this study was to compare incidence rates (IRs) of lymphoma and skin cancer between new users of topical tacrolimus or pimecrolimus and users of moderate- to high-potency topical corticosteroids (TCSs) and untreated subjects.
Methods: This is a multicenter cohort study with frequency matching by strata of propensity scores in population databases in the Netherlands, Denmark, Sweden, and the UK. Read More
Clin Epidemiol 2018 12;10:289-298. Epub 2018 Mar 12.
Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
Objective: Polypharmacy is the concomitant use of several drugs by a single person, and it increases the risk of adverse drug-related events in older adults. Little is known about the epidemiology of polypharmacy at the population level. We aimed to measure the prevalence and incidence of polypharmacy and to investigate the associated factors. Read More
Clin Epidemiol 2018 1;10:225-234. Epub 2018 Mar 1.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Background: The underlying mechanism of the association between thyroid function and atrial fibrillation (AF) is poorly understood, but epicardial adipose tissue (EAT) could be a promising mediator.
Methods: In the 1995 participants (mean age 64.5 years) from the population-based Rotterdam Study, we measured thyroid function (thyroid-stimulating hormone, free thyroxine [FT4]) and performed computed tomography to quantify EAT volumes. Read More
Clin Epidemiol 2018 28;10:215-222. Epub 2018 Feb 28.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Background: Epidemiologic studies combining exposure and outcome data with the collection of biosamples are needed to study gene-environment interactions that might contribute to the etiology of complex diseases such as pediatric Crohn's disease (CD). Nationwide registries, including those in Denmark and other Scandinavian countries, provide efficient and reliable sources of data for epidemiological studies evaluating the environmental determinants of disease. We performed a pilot study to test the feasibility of collecting salivary DNA to augment registry data in established cases of pediatric CD and randomly selected, population-based controls. Read More
Clin Epidemiol 2018 5;10:203-213. Epub 2018 Feb 5.
Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Background: The comparison of effectiveness and safety of anti-tumor necrosis factor-alpha agents for the treatment of inflammatory bowel disease (IBD) is relevant for clinical practice and stakeholders.
Objective: The objective of this study was to compare the risk of abdominal surgery, steroid utilization, and hospitalization for infection in Crohn's disease (CD) or ulcerative colitis (UC) patients newly treated with infliximab (IFX) or adalimumab (ADA).
Methods: A retrospective population-based cohort study was performed using health information systems data from Lazio region, Italy. Read More
Clin Epidemiol 2018 30;10:187-202. Epub 2018 Jan 30.
Department of Non-Communicable Disease Epidemiology.
Background: The relative risk of acute kidney injury (AKI) following different infections, and whether angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) modify the risk, is unclear. We aimed to determine the risks of hospital admission with AKI following infections (urinary tract infection [UTI], lower respiratory tract infection [LRTI], and gastroenteritis) among users of antihypertensive drugs.
Methods: We used UK electronic health records from practices contributing to the Clinical Practice Research Datalink linked to the Hospital Episode Statistics database. Read More
Clin Epidemiol 2018 25;10:179-186. Epub 2018 Jan 25.
Department of Neurobiology, Care Sciences and Society (NVS).
Background: Sedentary behavior is associated with health risks in adults. The potential benefits of reducing sedentary time may be dependent not only on decrease per se, but also on the type of activity it replaces. Few longitudinal studies have investigated the effects on mortality when replacing objectively assessed sedentary time with another physical activity (PA) behavior. Read More
Clin Epidemiol 2018 24;10:167-178. Epub 2018 Jan 24.
Centre for Chronic Disease, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Background: The American Heart Association (AHA) committee recently set a guideline to define and monitor the cardiovascular health status. This study aimed to estimate cardiovascular health status among Australian adults using the guideline.
Methods: We used data from a nationally representative sample of 7499 adults (age ≥18 years) from 2011 to 2012 Australian Health Survey. Read More
Clin Epidemiol 2018 18;10:159-165. Epub 2018 Jan 18.
Division of Internal Cardiology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
Background: Statins have been linked to new-onset osteoporotic fractures (NOFs), and different statins may alter the risk for the development of NOFs.
Aim: In this study, we investigated the association between different statins and the development of NOFs.
Patients And Methods: This was a longitudinal cohort study performed using data from claim forms submitted to the Taiwan Bureau of National Health Insurance, including case patients with NOFs from January 2004 to December 2013 and non-NOF subjects. Read More
Clin Epidemiol 2018 18;10:153-157. Epub 2018 Jan 18.
Medical Statistics Group, Design, Trials and Statistics, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
Background: A pilot study can be an important step in the assessment of an intervention by providing information to design the future definitive trial. Pilot studies can be used to estimate the recruitment and retention rates and population variance and to provide preliminary evidence of efficacy potential. However, estimation is poor because pilot studies are small, so sensitivity analyses for the main trial's sample size calculations should be undertaken. Read More
Clin Epidemiol 2018 19;10:143-152. Epub 2018 Jan 19.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg.
Background And Aim: Family history (FH) and genetic risk scores (GRSs) are increasingly used for risk stratification for colorectal cancer (CRC) screening. However, they were mostly considered alternatively rather than jointly. The aim of this study was to assess the potential of individual and joint risk stratification for CRC by FH and GRS. Read More
Clin Epidemiol 2018 15;10:133-141. Epub 2018 Jan 15.
Section of Epidemiology and Biostatistics.
Background: Despite widespread use of cardiovascular disease (CVD) preventive medications in cohorts used to develop CVD risk prediction models, only some incorporate baseline CVD pharmacotherapy and none account for treatment changes during study follow-up. Therefore, current risk prediction scores may underestimate the true CVD event risk. We examined changes in CVD pharmacotherapy over 5 years in preparation for developing new 5-year risk prediction models. Read More