Negative Symptoms and Reward Disturbances in Schizophrenia Before and After Antipsychotic Monotherapy.
- Mette Ødegaard Nielsen,
- Egill Rostrup,
- Brian Villumsen Broberg,
- Sanne Wulff,
- Birte Glenthøj
Clin EEG Neurosci 2017 Nov 1:1550059417744120. Epub 2017 Nov 1.
1 Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Copenhagen University Hospital, Mental Health Centre Glostrup, Denmark.
Background: Negative symptoms (NS) are a central part of the symptomatology of schizophrenia, which is highly correlated to the functional outcome. Disturbances of the brain reward system are suggested to be central in the pathogenesis of NS by decreasing motivation and hedonic experiences. In this study, we compared reward-related brain activity in patients improving and not improving in NS after treatment with amisulpride. Read More