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    600 results match your criteria Clinical EEG and Neuroscience [Journal]

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    Event-Related Potentials in the Clinical High-Risk (CHR) State for Psychosis: A Systematic Review.
    Clin EEG Neurosci 2018 Jan 1:1550059418755212. Epub 2018 Jan 1.
    1 Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
    There is emerging evidence that identification and treatment of individuals in the prodromal or clinical high-risk (CHR) state for psychosis can reduce the probability that they will develop a psychotic disorder. Event-related brain potentials (ERPs) are a noninvasive neurophysiological technique that holds promise for improving our understanding of neurocognitive processes underlying the CHR state. We aimed to systematically review the current literature on cognitive ERP studies of the CHR population, in order to summarize and synthesize the results, and their implications for our understanding of the CHR state. Read More

    Reevaluation of the Critically Ill Patients With Nonconvulsive Status Epilepticus by Using Salzburg Consensus Criteria.
    Clin EEG Neurosci 2018 Jan 1:1550059417752437. Epub 2018 Jan 1.
    5 Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
    Objective: We aimed to assess the usefulness of the Salzburg Consensus Criteria (SCC) for determining the prognosis of critically ill patients with nonconvulsive status epilepticus (NCSE).

    Methods: We retrospectively reviewed consecutive patients with unconsciousness followed up in the intensive care unit (ICU). Three clinical neurophysiologists, one of them blinded to clinical and laboratory data, reevaluated all EEG data independently and determined NCSE according to SCC. Read More

    NREM Sleep and Antiepileptic Medications Modulate Epileptiform Activity by Altering Cortical Synchrony.
    Clin EEG Neurosci 2017 Dec 1:1550059417747436. Epub 2017 Dec 1.
    1 Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
    Introduction: The activating role of non-rapid eye movement (NREM) sleep on epileptic cortex and conversely, the seizure remission brought about by antiepileptic medications, has been attributed to their effects on neuronal synchrony. This study aims to understand the role of neural synchrony of NREM sleep in promoting interictal epileptiform discharges (IEDs) in patients with epilepsy (PWE) by assessing the peri-IED phase synchrony during awake and sleep states. It also studies the role played by antiepileptic drugs (AEDs) on EEG desynchronization in the above cohort. Read More

    The Use of Quantitative EEG for Differentiating Frontotemporal Dementia From Late-Onset Bipolar Disorder.
    Clin EEG Neurosci 2017 Dec 1:1550059417750914. Epub 2017 Dec 1.
    1 Department of Psychology, Uskudar University, Istanbul, Turkey.
    The behavioral variant frontotemporal dementia (bvFTD) usually emerges with behavioral changes similar to changes in late-life bipolar disorder (BD) especially in the early stages. According to the literature, a substantial number of bvFTD cases have been misdiagnosed as BD. Since the literature lacks studies comparing differential diagnosis ability of electrophysiological and neuroimaging findings in BD and bvFTD, we aimed to show their classification power using an artificial neural network and genetic algorithm based approach. Read More

    Clinical and Biochemical Outcomes Following EEG Neurofeedback Training in Traumatic Brain Injury in the Context of Spontaneous Recovery.
    Clin EEG Neurosci 2017 Dec 1:1550059417744899. Epub 2017 Dec 1.
    1 Department of Clinical Psychology, National Institute of Mental Health & Neuro Sciences, Bengaluru, Karnataka, India.
    It has been found that reduction of posttraumatic stress symptoms is positively associated with the reduction of postconcussive symptoms. Cortisol is commonly used as a biomarker of stress. Understanding the role of posttraumatic stress and cortisol in symptom reduction has implication for neuropsychological rehabilitation particularly in the context of spontaneous recovery. Read More

    Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?
    Clin EEG Neurosci 2017 Dec 1:1550059417747155. Epub 2017 Dec 1.
    1 Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey.
    Background And Objective: Auditory startle response (ASR) was normal in juvenile myoclonic epilepsy whereas it was suppressed in progressive myoclonic epilepsy. However, both groups were using valproic acid/Na valproate (VPA) in different doses. Therefore, we aimed to analyze whether VPA has an impact on ASR in a cohort of epilepsy. Read More

    Subacute Encephalopathy With Seizures in Alcoholics (SESA) Presenting as Focal Nonconvulsive Status Epilepticus.
    Clin EEG Neurosci 2017 Dec 1:1550059417747435. Epub 2017 Dec 1.
    3 Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain.
    Purpose: To acquaint readers with the underrecognized subacute encephalopathy with seizures in chronic alcoholics (SESA) that has more recently been associated with different types of status epilepticus.

    Methods: Case reports and review of the literature on SESA and nonconvulsive status epilepticus (NCSE).

    Results: Two cases: one with alternating bifrontoparietal NCSE, and one with focal, confusional NCSE, with imaging and EEG correlates. Read More

    Use of Transcranial Direct Stimulation in the Treatment of Negative Symptoms of Schizophrenia.
    Clin EEG Neurosci 2018 Jan;49(1):18-26
    1 Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, Children Hospital Bambino Gesù, Rome, Italy.
    Schizophrenia is a debilitating disease that affects approximately 1% of the population. Negative symptoms are among the major determinants of the functional impairment and a significant proportion of patients with negative symptoms will continue to experience these symptoms despite antipsychotic medications. There are promising results in the application of brain stimulation, particularly transcranial direct current stimulation (tDCS), for the reduction of negative symptoms of schizophrenia. Read More

    Impact of Reward and Loss Anticipation on Cognitive Control: An Event-Related Potential Study in Subjects With Schizophrenia and Healthy Controls.
    Clin EEG Neurosci 2018 Jan;49(1):46-54
    1 Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
    Introduction: Deficits of cognitive functions and motivation are core aspects of schizophrenia. The interaction of these deficits might contribute to impair the ability to flexibly adjust behavior in accordance with one's intentions and goals. Many studies have focused on the anterior N2 as a correlate of cognitive control based on motivational value. Read More

    Electrophysiological Markers of Motivation in Psychosis.
    Clin EEG Neurosci 2018 Jan;49(1):8-11
    1 Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
    Motivation is associated with electrophysiological markers, such as awake state delta oscillation and frontal alpha asymmetry, as well as event-related potentials, such as error-related negativity, feedback-related negativity, and prepulse inhibition. These indicators provide an objective measure of motivational deficits in psychiatric conditions, and response to treatment. Also, these modalities of brain activities are drawing attention as a target of neurofeedback training. Read More

    Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex.
    Clin EEG Neurosci 2018 Jan;49(1):55-65
    1 Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
    The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural and functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at the level of the nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well as amygdala (Amy) and insular cortex (IC). However, the association of the reported abnormalities with avoliton-apathy is still controversial. Read More

    The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature.
    Clin EEG Neurosci 2018 Jan;49(1):12-17
    4 Centre for Psychology, Kristianstad University, Kristianstad, Sweden.
    Negative symptoms of schizophrenia have a negative impact on psychosocial functioning and disease outcome. It is therefore important to investigate the pathophysiology underlying negative symptoms as this may aid the development of better treatment. In the current article, examples from studies investigating neural correlates of negative symptoms in schizophrenia are given. Read More

    Relationship Between Persistent Negative Symptoms and Findings of Neurocognition and Neuroimaging in Schizophrenia.
    Clin EEG Neurosci 2018 Jan;49(1):27-35
    1 Department of Psychiatry, Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey.
    Negative symptoms are defined as loss or reduction of otherwise present behaviors or functions in illness situation, and they have constituted an important aspect of schizophrenia. Although negative symptoms have usually been considered as a single entity, neurobiological investigations yielded discrepant results. To overcome challenges that derive from this discrepancy, researchers have proposed several approaches to structure negative symptoms into more homogenous constructs. Read More

    Change in Quantitative EEG Theta Cordance as a Potential Predictor of Repetitive Transcranial Magnetic Stimulation Clinical Outcome in Major Depressive Disorder.
    Clin EEG Neurosci 2017 Nov 1:1550059417746212. Epub 2017 Nov 1.
    1 Laboratory of Brain, Behavior, and Pharmacology, TMS Clinical and Research Program, Neuromodulation Division, Semel Institute at UCLA, Los Angeles, CA, USA.
    Repetitive transcranial magnetic stimulation (rTMS) has demonstrated efficacy in major depressive disorder (MDD), although clinical outcome is variable. Change in the resting-state quantitative electroencephalogram (qEEG), particularly in theta cordance early in the course of treatment, has been linked to antidepressant medication outcomes but has not been examined extensively in clinical rTMS. This study examined change in theta cordance over the first week of clinical rTMS and sought to identify a biomarker that would predict outcome at the end of 6 weeks of treatment. Read More

    Automatic Seizure Detection Based on Morphological Features Using One-Dimensional Local Binary Pattern on Long-Term EEG.
    Clin EEG Neurosci 2017 Dec 1:1550059417744890. Epub 2017 Dec 1.
    5 College of Engineering, The Ohio State University, Columbus, OH, USA.
    Epileptic neurological disorder of the brain is widely diagnosed using the electroencephalography (EEG) technique. EEG signals are nonstationary in nature and show abnormal neural activity during the ictal period. Seizures can be identified by analyzing and obtaining features of EEG signal that can detect these abnormal activities. Read More

    Ictal Rhythmic Alpha Sinusoidal Waves in 3 Cases of Anti-NMDAR Encephalitis.
    Clin EEG Neurosci 2017 Nov 1:1550059417745185. Epub 2017 Nov 1.
    1 Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
    Previous studies have shown that extreme delta brush and high beta/delta power ratio on electroencephalogram are suggestive of anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. Here we report 3 anti-NMDAR encephalitis patients with ictal rhythmic alpha sinusoidal waves in temporal regions, which suggested electrographic seizures in anti-NMDAR encephalitis and indicated potential for seizure occurrence in the future. Rhythmic alpha sinusoidal waves may be an electrographic feature and helpful in distinguishing anti-NMDAR encephalitis. Read More

    Quantitative EEG Parameters for Prediction of Outcome in Severe Traumatic Brain Injury: Development Study.
    Clin EEG Neurosci 2017 Nov 1:1550059417742232. Epub 2017 Nov 1.
    3 University of Turku, Turku, Finland.
    Monitoring of quantitative EEG (QEEG) parameters in the intensive care unit (ICU) can aid in the treatment of traumatic brain injury (TBI) patients by complementing visual EEG review done by an expert. We performed an explorative study investigating the prognostic value of 59 QEEG parameters in predicting the outcome of patients with severe TBI. Continuous EEG recordings were done on 28 patients with severe TBI in the ICU of Turku University Hospital. Read More

    Heightened Background Cortical Synchrony in Patients With Epilepsy: EEG Phase Synchrony Analysis During Awake and Sleep Stages Using Novel Ensemble Measure.
    Clin EEG Neurosci 2017 Mar 1:1550059417696559. Epub 2017 Mar 1.
    1 Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
    Introduction: Excessive cortical synchrony within neural ensembles has been implicated as an important mechanism driving epileptiform activity. The current study measures and compares background electroencephalographic (EEG) phase synchronization in patients having various types of epilepsies and healthy controls during awake and sleep stages.

    Methods: A total of 120 patients with epilepsy (PWE) subdivided into 3 groups (juvenile myoclonic epilepsy [JME], temporal lobe epilepsy [TLE], and extra-temporal lobe epilepsy [Ex-TLE]; n = 40 in each group) and 40 healthy controls were subjected to overnight polysomnography. Read More

    Association Between Pathology and Electroencephalographic Activity in Parkinson's Disease.
    Clin EEG Neurosci 2017 Feb 1:1550059417696179. Epub 2017 Feb 1.
    1 Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
    Introduction: The key mechanisms that connect Parkinson's disease pathology with dementia are unclear. We tested the hypothesis that the quantitative spectral electroencephalographic measure, delta bandpower, correlates with Lewy type synucleinopathy on pathological examination in Parkinson's disease. As a corollary hypothesis, we analyzed whether there would be delta bandpower electroencephalographic differences between Parkinson's disease dementia cases with and without pathological criteria for Alzheimer's disease. Read More

    How Long Should Routine EEG Be Recorded to Get Relevant Information?
    Clin EEG Neurosci 2017 Mar 1:1550059417698549. Epub 2017 Mar 1.
    1 Clinical Neurophysiology Unit, Neurology Department, University Grenoble Alpes Hospital, Grenoble, France.
    Objective: The optimal duration of routine EEG (rEEG) has not been determined on a clinical basis. This study aims to determine the time required to obtain relevant information during rEEG with respect to the clinical request.

    Method: All rEEGs performed over 3 months in unselected patients older than 14 years in an academic hospital were analyzed retrospectively. Read More

    Delta Brush Pattern Is Not Unique to NMDAR Encephalitis: Evaluation of Two Independent Long-Term EEG Cohorts.
    Clin EEG Neurosci 2017 Feb 1:1550059417693168. Epub 2017 Feb 1.
    5 Department of Neuroscience, Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey.
    Purpose: Although its specificity has not previously been investigated in other cohorts, delta brush pattern (DBP) is increasingly reported in the EEGs of patients with anti- N-methyl-d-aspartate receptor (NMDAR) encephalitis.

    Methods: We aimed to investigate the DBP in the EEGs of 2 cohorts; patients with change in consciousness for various causes monitored in the intensive care unit (ICU) (n = 106) and patients with mesial temporal lobe epilepsy (MTLE) with or without antineuronal antibodies (n = 76).

    Results: These patients were investigated for the presence of DBP, defined as an EEG pattern characterized by delta activity at 1 to 3 Hz with superimposed bursts of rhythmic 12- to 30-Hz activity. Read More

    Status Epilepticus and Multiple Sclerosis: A Case Presentation and Literature Review.
    Clin EEG Neurosci 2017 Jan 1:1550059417693732. Epub 2017 Jan 1.
    1 Department of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Purpose: To search the literature for the frequency, pathogenesis, prognosis, and treatment of seizures and status epilepticus (SE) in patients with multiple sclerosis (MS).

    Methods: We report 2 patients with MS who presented with SE and review the literature.

    Results: Seizures and SE episodes worsened during MS relapses in the first patient. Read More

    The Significance of Impulsive Error in Children With ADHD.
    Clin EEG Neurosci 2017 Nov 1:1550059417742297. Epub 2017 Nov 1.
    1 Institute of Allied Health Science, National Cheng Kung University, Taiwan.
    A deficit of inhibition ability is a neuropsychological problem in children with attention deficit hyperactivity disorder (ADHD). We investigated whether in children who made impulsive error (IE), less error-related negativity (ERN) would correlate with poorer executive attention functions (EAFs). Ninety children (49 with ADHD and 41 without ADHD) were investigated by a 4-minute simple reaction time task and simultaneous electroencephalogram. Read More

    Negative Symptoms and Reward Disturbances in Schizophrenia Before and After Antipsychotic Monotherapy.
    Clin EEG Neurosci 2018 Jan 17;49(1):36-45. Epub 2017 Nov 17.
    1 Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Copenhagen University Hospital, Mental Health Centre Glostrup, Denmark.
    Background: Negative symptoms (NS) are a central part of the symptomatology of schizophrenia, which is highly correlated to the functional outcome. Disturbances of the brain reward system are suggested to be central in the pathogenesis of NS by decreasing motivation and hedonic experiences. In this study, we compared reward-related brain activity in patients improving and not improving in NS after treatment with amisulpride. Read More

    Exploration of the Pathophysiology of Chronic Pain Using Quantitative EEG Source Localization.
    Clin EEG Neurosci 2018 Mar 6;49(2):103-113. Epub 2017 Nov 6.
    5 Departments of Neurology and Radiology, NYU Medical Center, New York, NY, USA.
    Chronic pain affects more than 35% of the US adult population representing a major public health imperative. Currently, there are no objective means for identifying the presence of pain, nor for quantifying pain severity. Through a better understanding of the pathophysiology of pain, objective indicators of pain might be forthcoming. Read More

    The Difficulty in Finding Relationships Between ERPs and Clinical Symptoms of Schizophrenia.
    Clin EEG Neurosci 2018 Jan 2;49(1):6-7. Epub 2017 Nov 2.
    1 San Francisco Veterans Administration Medical Center, San Francisco, CA, USA.
    It has been surprisingly difficult to find associations between neural signatures of schizophrenia and the symptoms that define it. That is, many of the legacy components of the event-related potential (ERP)- P50, N100, P200, P300-are reduced in patients with schizophrenia, in first-degree relatives of patients with schizophrenia, in schizophrenia patients early in their illness, and even in people at clinical high risk for schizophrenia. Nevertheless, these ERP components tend to be relatively insensitive to symptoms. Read More

    Evaluating Brain-Computer Interface Performance in an ALS Population: Checkerboard and Color Paradigms.
    Clin EEG Neurosci 2018 Mar 27;49(2):114-121. Epub 2017 Oct 27.
    1 Department of Psychology, East Tennessee State University, Johnson City TN, USA.
    The objective of this study was to investigate the performance of 3 brain-computer interface (BCI) paradigms in an amyotrophic lateral sclerosis (ALS) population (n = 11). Using a repeated-measures design, participants completed 3 BCI conditions: row/column (RCW), checkerboard (CBW), and gray-to-color (CBC). Based on previous studies, it is hypothesized that the CBC and CBW conditions will result in higher accuracy, information transfer rate, waveform amplitude, and user preference over the RCW condition. Read More

    Features of Simultaneous Scalp and Intracranial EEG That Predict Localization of Ictal Onset Zone.
    Clin EEG Neurosci 2017 Oct 1:1550059417738688. Epub 2017 Oct 1.
    2 University of Pittsburgh Comprehensive Epilepsy Center (UPCEC), University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Objective: To assess the utility of simultaneous scalp EEG in patients with focal epilepsy undergoing intracranial EEG evaluation after a detailed presurgical testing, including an inpatient scalp video EEG evaluation.

    Methods: Patients who underwent simultaneous scalp and intracranial EEG (SSIEEG) monitoring were classified into group 1 or 2 depending on whether the seizure onset zone was delineated or not. Seizures were analyzed using the following 3 EEG features at the onset of seizures latency, location, and pattern. Read More

    The Success Rate of Neurology Residents in EEG Interpretation After Formal Training.
    Clin EEG Neurosci 2018 Mar 10;49(2):136-140. Epub 2017 Oct 10.
    2 Department of Biostatistics, Hacettepe University, Ankara, Turkey.
    EEG is an important tool for neurologists in both diagnosis and classification of seizures. It is not uncommon in clinical practice to see patients who were erroneously diagnosed as epileptic. Most of the time incorrect interpretation of EEG contributes significantly to this problem. Read More

    Neuronal Dysexcitability May Be a Biomarker of Migraine: A Visual Evoked Potential Study.
    Clin EEG Neurosci 2017 Sep 1:1550059417734106. Epub 2017 Sep 1.
    1 Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    We report neuronal sensitization and impaired habituation in migraine using pattern reversal visual evoked potential (PRVEP) and correlate these with clinical characteristics of migraine. Sixty-five migraineurs and 30 healthy controls were included. A detailed clinical examination was done and migraine characteristics, including migraine trigger, photophobia, phonophobia, and allodynia were noted. Read More

    Peri-ictal Prone Position Is Associated With Independent Risk Factors For Sudden Unexpected Death In Epilepsy: A Controlled Video-EEG Monitoring Unit Study.
    Clin EEG Neurosci 2017 Sep 1:1550059417733385. Epub 2017 Sep 1.
    1 Departments of Neurology and Clinical Neurophysiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
    Introduction: Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in patients with chronic drug-resistant epilepsy, and peri-ictal prone position has been elucidated as a risk factor for SUDEP. We aimed to investigate consecutive patients in peri-ictal prone positions in our video EEG monitoring (VEM) unit and compare patients with and without peri-ictal prone position to emphasize its relationship with other independent risk factors for SUDEP.

    Methods: We retrospectively screened all patients with peri-ictal prone position who underwent VEM for a 10-year period and these patients constituted the prone (+) group. Read More

    Neural Processing of Musical and Vocal Emotions Through Cochlear Implants Simulation.
    Clin EEG Neurosci 2017 Sep 1:1550059417733386. Epub 2017 Sep 1.
    1 International Laboratory for Brain Music and Sound Research, Center for Research on Brain, Language and Music, Department of Psychology, University of Montreal, Montreal, Quebec, Canada.
    Cochlear implants (CIs) partially restore the sense of hearing in the deaf. However, the ability to recognize emotions in speech and music is reduced due to the implant's electrical signal limitations and the patient's altered neural pathways. Electrophysiological correlations of these limitations are not yet well established. Read More

    Transcranial Direct Current Stimulation in Depression and Psychosis: A Systematic Review.
    Clin EEG Neurosci 2018 Mar 20;49(2):93-102. Epub 2017 Sep 20.
    1 National Center of Neurology and Psychiatry, Tokyo, Japan.
    Transcranial direct current stimulation, one of the neuromodulation paradigms, is attracting interest as a novel method to treat various central nervous system disorders. It is safe, portable, and cost-effective, and has been applied experimentally for patients with various neuropsychiatric conditions. For the clinical importance and preliminary positive results, growing number of randomized controlled trials to patients with depression or schizophrenia are reported, followed by systematic reviews and meta-analyses. Read More

    Maturation of Binocular, Monocular Grating Acuity and of the Visual Interocular Difference in the First 2 Years of Life.
    Clin EEG Neurosci 2017 Aug 1:1550059417723804. Epub 2017 Aug 1.
    1 Laboratório de Psicofisiologia Sensorial, Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brazil.
    The sweep visual evoked potential method (sVEP) is a powerful tool for measurement of visual acuity in infants. Despite the applicability and reliability of the technique in measuring visual functions the understanding of sVEP acuity maturation and how interocular difference of acuity develops in early infancy, as well as the availability of normality ranges, are rare in the literature. We measured binocular and monocular sVEPS acuities in 481 healthy infants aged from birth to 24 months without ophthalmological diseases. Read More

    The Nature of EEG Reactivity to Light, Sound, and Pain Stimulation in Neurosurgical Comatose Patients Evaluated by a Quantitative Method.
    Clin EEG Neurosci 2017 Nov 28;48(6):428-437. Epub 2017 Aug 28.
    1 Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
    EEG reactivity (EEG-R) is regarded as an important parameter in coma prognosis but knowledge is sparse on the nature of EEG changes due to different kinds of stimulation and their prognostic significance. EEG-R was quantified in a study of 39 comatose neurosurgical patients. Six 30-second standardized visual, auditory, and painful stimulations were applied. Read More

    Do Video-EEG Monitoring Findings in ICU Patients With Acute Stroke Predict Development of Seizures and Survival During Follow-up?
    Clin EEG Neurosci 2017 Nov 28;48(6):417-421. Epub 2017 Aug 28.
    1 Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Purpose: Ischemic or hemorrhagic stroke are among the most common causes of seizures, especially in the elderly. EEG is the only technique that can detect epileptiform abnormalities (EA) and nonconvulsive status epilepticus (NCSE), which may negatively affect recovery of these patients. Herein we aimed to investigate the potential predictive value of long-term EEG findings in terms of poststroke seizures (PSS) and survival, in stroke patients followed up in the neurological intensive care unit (NICU). Read More

    Nonlinear Recurrent Dynamics and Long-Term Nonstationarities in EEG Alpha Cortical Activity: Implications for Choosing Adequate Segment Length in Nonlinear EEG Analyses.
    Clin EEG Neurosci 2018 Mar 14;49(2):71-78. Epub 2017 Aug 14.
    3 Research Institute Brainclinics, Nijmegen, The Netherlands.
    Nonlinear analysis of EEG recordings allows detection of characteristics that would probably be neglected by linear methods. This study aimed to determine a suitable epoch length for nonlinear analysis of EEG data based on its recurrence rate in EEG alpha activity (electrodes Fz, Oz, and Pz) from 28 healthy and 64 major depressive disorder subjects. Two nonlinear metrics, Lempel-Ziv complexity and scaling index, were applied in sliding windows of 20 seconds shifted every 1 second and in nonoverlapping windows of 1 minute. Read More

    Retrospective Analysis of Nonepileptic Patients With Isolated Epileptiform Discharges Treated With Anticonvulsants.
    Clin EEG Neurosci 2017 Sep 1;48(5):322-326. Epub 2017 Mar 1.
    3 Department of Clinical Psychology, Saybrook University, Oakland, CA, USA.
    Many antiepileptic drugs (AEDs) have been tested on nonepileptic patients with a variety of diagnoses. The Food and Drug Administration has only approved certain AEDs for a small number of psychiatric conditions. There are few studies of nonepileptic patients that recommend an empirical trial of AEDs when isolated epileptiform discharges (IEDs) are identified in the electroencephalogram (EEG). Read More

    Longitudinal Dynamics of 3-Dimensional Components of Selfhood After Severe Traumatic Brain Injury: A qEEG Case Study.
    Clin EEG Neurosci 2017 Sep 1;48(5):327-337. Epub 2017 Feb 1.
    1 BM-Science-Brain and Mind Technologies Research Centre, Espoo, Finland.
    In this report, we describe the case of a patient who sustained extremely severe traumatic brain damage with diffuse axonal injury in a traffic accident and whose recovery was monitored during 6 years. Specifically, we were interested in the recovery dynamics of 3-dimensional components of selfhood (a 3-dimensional construct model for the complex experiential selfhood has been recently proposed based on the empirical findings on the functional-topographical specialization of 3 operational modules of brain functional network responsible for the self-consciousness processing) derived from the electroencephalographic (EEG) signal. The analysis revealed progressive (though not monotonous) restoration of EEG functional connectivity of 3 modules of brain functional network responsible for the self-consciousness processing, which was also paralleled by the clinically significant functional recovery. Read More

    Childhood-Onset Epileptic Encephalopathy Associated With Isolated Focal Cortical Dysplasia and a Novel TSC1 Germline Mutation.
    Clin EEG Neurosci 2017 Mar 1:1550059417697841. Epub 2017 Mar 1.
    1 Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr. von Haunersches Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
    Tuberous sclerosis complex (TSC) is an autosomal-dominant inheritable neurocutaneous disease due to mutations within the TSC1 and TSC2 genes. Many patients present with West syndrome, a severe epilepsy syndrome characterized by the triad of infantile spasms, an interictal electroencephalogram (EEG) pattern termed hypsarrhythmia (continuous slow activity with an amplitude higher than 300 µV and multiregional spikes/polyspikes/sharp waves) and developmental regression. In this study, we report on a previously healthy patient with positive family history of epilepsy with new-onset epileptic encephalopathy at the age of 9 years. Read More

    Local Differences in Computational Sleep Depth Parameters in Healthy School-aged Children.
    Clin EEG Neurosci 2017 Nov 5;48(6):393-402. Epub 2017 Jul 5.
    3 Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
    Objective: Slow wave sleep in children reflects several processes, such as sleep pressure, synaptic density, and cortical maturation. Deep sleep in children is abundant and our aim was to discover whether examining electroencephalography (EEG) mean frequency would help separate these processes.

    Methods: Sleep EEG of 28 generally healthy 7- to 11-year-old children (14 first graders, 14 third graders, 14 girls, 14 boys) was analyzed. Read More

    High-Intensity Chronic Stroke Motor Imagery Neurofeedback Training at Home: Three Case Reports.
    Clin EEG Neurosci 2017 Nov 5;48(6):403-412. Epub 2017 Jul 5.
    1 Neuropsychology Lab, Department of Psychology, European Medical School, University of Oldenburg, Oldenburg, Germany.
    Motor imagery (MI) with neurofeedback has been suggested as promising for motor recovery after stroke. Evidence suggests that regular training facilitates compensatory plasticity, but frequent training is difficult to integrate into everyday life. Using a wireless electroencephalogram (EEG) system, we implemented a frequent and efficient neurofeedback training at the patients' home. Read More

    Accuracy of Limited-Montage Electroencephalography in Monitoring Postanoxic Comatose Patients.
    Clin EEG Neurosci 2017 Nov 22;48(6):422-427. Epub 2017 Jun 22.
    1 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
    Background: Continuous EEG (cEEG) monitoring may help to identify the small percentage of adults with hypoxic-ischemic encephalopathy (HIE) who will regain consciousness if allowed sufficient time. However, the limited yield in this population has led some to question the cost-effectiveness cEEG monitoring in this population. We hypothesized that limited-montage cEEG could provide essentially the same neurophysiologic information at lower cost. Read More

    Comparing EEG Nonlinearity in Deficit and Nondeficit Schizophrenia Patients: Preliminary Data.
    Clin EEG Neurosci 2017 Nov 16;48(6):376-382. Epub 2017 Jun 16.
    4 Department of Psychiatry, University of Missouri-Kansas City, Kansas City, USA.
    Electroencephalogram (EEG) contains valuable information obtained noninvasively that can be used for assessment of brain's processing capacity of patients with psychiatric disorders. The purpose of the present work was to evaluate possible differences in EEG complexity between deficit (DS) and nondeficit (NDS) subtypes of schizophrenia as a reflection of the cognitive processing capacities in these groups. A particular nonlinear metric known as Lempel-Ziv complexity (LZC) was used as a computational tool in order to determine the randomness in EEG alpha band time series from 3 groups (deficit schizophrenia [n = 9], nondeficit schizophrenia [n = 10], and healthy controls [n = 10]) according to time series randomness. Read More

    Is There an Association Between Mismatch Negativity and Cortical Thickness in Schizophrenia Patients?
    Clin EEG Neurosci 2017 Nov 14;48(6):383-392. Epub 2017 Jun 14.
    1 Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
    Introduction: Mismatch negativity (MMN) is thought to reflect preattentive, automatic auditory processing. Reduced MMN amplitude is among the most robust findings in schizophrenia research. MMN generators have been shown to be located in the temporal and frontal cortices, which are key areas in the pathophysiology of schizophrenia. Read More

    Determining Electrode Placement for Transcranial Direct Current Stimulation: A Comparison of EEG- Versus TMS-Guided Methods.
    Clin EEG Neurosci 2017 Nov 22;48(6):367-375. Epub 2017 May 22.
    1 Department of Physical Medicine and Rehabilitation, Program in Rehabilitation Science, University of Minnesota, Minneapolis, MN, USA.
    Transcranial direct current stimulation (tDCS) is increasingly researched as an adjuvant to motor rehabilitation for children with hemiparesis. The optimal method for the primary motor cortex (M1) somatotopic localization for tDCS electrode placement has not been established. The objective, therefore, was to determine the location of the M1 derived using the 10/20 electroencephalography (EEG) system and transcranial magnetic stimulation (TMS) in children with hemiparesis (CWH) and a comparison group of typically developing children (TDC). Read More

    Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will Benefit From Sedatives in Improving Positive Airway Pressure Adherence in Sleep Apnea to 90.
    Clin EEG Neurosci 2017 May 1:1550059417709882. Epub 2017 May 1.
    1 Sleep & Attention Disorders Institute, Sterling Heights, MI, USA.
    Positive airway pressure (PAP) is the preferred treatment for obstructive sleep apnea (OSA), but adherence is low. Educational or ongoing supportive intervention improves the number of PAP adherent patients from the 50% to the 70% range. A common side effect of PAP is increased awakenings. Read More

    New-Onset Fixation-Off Sensitivity or Scotosensitivity in an Adult Male After Bilateral Embolic Strokes of the Parietal and Occipital Regions.
    Clin EEG Neurosci 2017 Nov 22;48(6):413-416. Epub 2017 May 22.
    1 Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.
    A 50-year old male suffered new-onset clinical and subclinical seizures provoked by acute bilateral embolic strokes in the parietal and occipital regions as a complication of aortic valve replacement surgery. After successful treatment of these refractory symptomatic seizures with intravenous propofol and antiseizure medications, video-EEG recordings revealed acute and transient fixation-off sensitivity or scotosensitivity that resolved within 10 weeks. Read More

    Neurofeedback-Based Enhancement of Single Trial Auditory Evoked Potentials: Feasibility in Healthy Subjects.
    Clin EEG Neurosci 2018 Mar 18;49(2):79-92. Epub 2017 May 18.
    1 Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
    Previous studies showed a global reduction of the event-related potential component N100 in patients with schizophrenia, a phenomenon that is even more pronounced during auditory verbal hallucinations. This reduction assumingly results from dysfunctional activation of the primary auditory cortex by inner speech, which reduces its responsiveness to external stimuli. With this study, we tested the feasibility of enhancing the responsiveness of the primary auditory cortex to external stimuli with an upregulation of the event-related potential component N100 in healthy control subjects. Read More

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