4,413,925 results match your criteria Clinical Cosmetic and Investigational Dermatology [Journal]


Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18491DOI Listing
April 2019
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Factors Influencing Motor Outcome of Hippotherapy in Children with Cerebral Palsy.

Neuropediatrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective:  This study was aimed to identify individual factors influencing the gross motor outcome of hippotherapy in children with cerebral palsy (CP).

Methods:  One hundred and forty-six children with CP (mean age: 5.78 ± 1. Read More

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http://dx.doi.org/10.1055/s-0039-1685526DOI Listing

Effects of systematic bisphosphonate use in patients under orthodontic treatment: a systematic review.

Eur J Orthod 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthodontics, School of Health Sciences, Faculty of Dentistry, Aristotle University of Thessaloniki, Greece.

Background: Bisphosphonates are a class of drugs prescribed for several osseous related disorders owing to their ability to regulate bone turnover, which could in turn affect orthodontic treatment outcomes.

Objective: To examine the effect of bisphosphonate (BP) use on orthodontic patients through clinical and radiographic measurements.

Search Methods: Systematic and unrestricted search of 17 databases complemented with additional hand-searches were performed up to March 2019. Read More

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http://dx.doi.org/10.1093/ejo/cjz021DOI Listing

Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of Minnesota and Minneapolis VA Health Care System, Minneapolis, Minnesota (H.A.F., R.M., K.E.E., K.U., B.C.T., T.J.W.).

Background: Optimal long-term osteoporosis drug treatment (ODT) is uncertain.

Purpose: To summarize the effects of long-term ODT and ODT discontinuation and holidays.

Data Sources: Electronic bibliographic databases (January 1995 to October 2018) and systematic review bibliographies. Read More

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http://dx.doi.org/10.7326/M19-0533DOI Listing

Advising Patients on How to Achieve Long-Term Weight Loss.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Baltimore VA Medical Center Geriatric Research Education and Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.).

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http://dx.doi.org/10.7326/M19-0782DOI Listing

Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.

Neuropsychopharmacology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmaceutical Biosciences, Medical Mass Spectrometry Imaging, National Resource for Mass Spectrometry Imaging, Science for Life Laboratory, Uppsala University, Box 591, Uppsala, SE, 75124, Sweden.

The neurotransmitter of the cholinergic system, acetylcholine plays a major role in the brain's cognitive function and is involved in neurodegenerative disorders. Here, we present age-related alterations of acetylcholine levels after administration of the acetylcholinesterase inhibitor drug tacrine in normal mice. Using a quantitative, robust and molecular-specific mass spectrometry imaging method we found that tacrine administration significantly raised acetylcholine levels in most areas of sectioned mice brains, inter alia the striatum, hippocampus and cortical areas. Read More

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http://dx.doi.org/10.1038/s41386-019-0397-5DOI Listing

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

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http://dx.doi.org/10.18632/aging.101900DOI Listing

Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models.

Comput Biol Med 2019 Mar 23;108:263-275. Epub 2019 Mar 23.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: https://kclpure.kcl.ac.uk/portal/martin.bishop.html.

Identification of targets for catheter ablation of ventricular tachycardias (VTs) remains a significant challenge. VTs are often driven by re-entrant circuits resulting from a complex interaction between the front (activation) and tail (repolarization) of the electrical wavefront. Most mapping techniques do not take into account the tissue repolarization which may hinder the detection of ablation targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193009
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.018DOI Listing
March 2019
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miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Mol Ther Nucleic Acids 2019 Mar 13;16:391-406. Epub 2019 Mar 13.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli," 80138 Naples, Italy; IRGS, Biogem, Molecular and Precision Oncology Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address:

miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis). Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.023DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X193009
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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing
April 2019
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A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

Clin Neurophysiol 2019 Apr 11;130(6):1017-1024. Epub 2019 Apr 11.

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, IS, Italy.

Objective: we investigated the effect of anodal transcranial direct current stimulation (tDCS) applied over the pharyngeal motor area in dysphagia associated with multiple sclerosis (MS).

Methods: Eighteen MS patients with dysphagia associated with brainstem involvement were randomized to receive either "real" or "sham" tDCS.

Primary Outcome: The Penetration/Aspiration Scale (PAS). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.04.003DOI Listing

The case series of peritonitis due to perforated peptic ulcer: How does conservative management play role?

Int J Surg Case Rep 2019 Apr 5;58:74-76. Epub 2019 Apr 5.

Department of Surgery, Songkhla Hospital, Muang, Songkhla, 90100, Thailand. Electronic address:

Introduction: Surgical intervention is a conventional treatment for perforated peptic ulcer patients. This study aims to determine whether and how conservative non-operative management plays role in patients with pneumoperitoneum-peritonitis due to perforated peptic ulcers.

Methods: A 9-year retrospective study was conducted in patients, who visit one surgeon service, with peritonitis due to perforated peptic ulcer and received non-operation conservative treatment. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.054DOI Listing

Simultaneous small bowel and colon obstruction due to splenosis. A case report and review of literature.

Int J Surg Case Rep 2019 Mar 30;58:63-66. Epub 2019 Mar 30.

Department of General and Digestive Surgery, Maritime Hospital, Jbeil, Lebanon.

Introduction: Splenosis, an autotransplantation of splenic tissues in another compartment of the body, is only symptomatic when hematologic diseases have recurred or compression of other adjacent structures have occurred. Therefore, we report a clinical case of a patient with bowel obstruction due to splenosis.

Case Presentation: A patient with a history of splenectomy, presented to the emergency room for abdominal pain and obstipation, suggesting intestinal obstruction which is also seen on CT scan. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.040DOI Listing

Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy.

J Pharm Biomed Anal 2019 Apr 9;172:1-8. Epub 2019 Apr 9.

Jack Jumper Allergy Program, Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania, 7001, Australia; School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia.

A major challenge in broader clinical application of Jack Jumper ant venom immunotherapy (JJA VIT) is the scarcity of ant venom which needs to be manually harvested from wild ants. Adjuvants are commonly used for antigen sparing in other vaccines, and thereby could potentially have major benefits to extend JJA supplies if they were to similarly enhance JJA VIT immunogenicity. The purpose of this study was to evaluate the physicochemical and microbiological stability and murine immunogenicity of low-dose JJA VIT formulated with a novel polysaccharide adjuvant referred to as delta inulin or Advax™. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.017DOI Listing

"Closed-Incision Negative-Pressure Therapy Efficacy in Abdominal Wall Reconstruction in High-Risk Patients: A Meta-Analysis".

J Surg Res 2019 Apr 19;241:63-71. Epub 2019 Apr 19.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Obesity is a known risk factor for surgical complications. Closed-incision negative-pressure therapy (ciNPT) has been used anecdotally in high-risk patients to prevent wound complications and infection. This meta-analysis aims to evaluate the efficacy of ciNPT in reducing the incidence of wound complications and infection in abdominal wall reconstruction. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.033DOI Listing

Speciation analysis of arsenic in urine samples from APL patients treated with single agent AsO by HPLC-HG-AFS.

J Pharm Biomed Anal 2019 Apr 8;171:212-217. Epub 2019 Apr 8.

Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Arsenic trioxide [AsO, arsenite (As) in solution] has been applied successfully for the treatment of acute promyelocytic leukemia (APL). The arsenic speciation analysis of urine is critical to reveal the metabolic mechanism and the relationship between arsenic species and the clinical response. To characterize the arsenic species in urine, a simple and robust HPLC-HG-AFS method was developed and validated to quantify the levels of arsenic species [As and its metabolites, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenate (As)] in urine samples from 66 patients with APL. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.014DOI Listing

Development and validation of a multiplexed drug level assay in support of combination biologics therapy clinical studies.

J Pharm Biomed Anal 2019 Apr 13;171:204-211. Epub 2019 Apr 13.

Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Rd, Kenilworth, NJ 07033, USA.

Clinical development of biotherapeutics for combination therapy requires monitoring the concentrations of both drugs in biological samples. Traditionally, two assays are required to measure drug levels one at a time, which poses challenges in sample management, data reporting, and cost. The Meso Scale Discovery (MSD®) U-PLEX platform provides a simple and flexible way to create custom multiplex ligand binding assays (LBAs). Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.021DOI Listing

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

Deterministic-tractography-based approach for diagnosis and disease monitoring of amyotrophic lateral sclerosis.

Clin Neurol Neurosurg 2019 Apr 15;181:73-75. Epub 2019 Apr 15.

Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Objectives: Upper and lower motor neuron signs are required for the diagnosis of amyotrophic lateral sclerosis. The detection of upper motor neuron signs is key for the diagnosis, as quite a few patients with amyotrophic lateral sclerosis lack upper motor neuron signs during the course of disease. This study sought to investigate whether deterministic tractography of the corticospinal tract, reflecting upper motor neuron signs, could be a surrogate biomarker for amyotrophic lateral sclerosis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.04.015DOI Listing

Differential associations of locus of control with anxiety, depression and life-events: A five-wave, nine-year study to test stability and change.

J Affect Disord 2019 Apr 11;253:26-34. Epub 2019 Apr 11.

University of Groningen, University Medical Center Groningen (UMCG), Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotional regulation (ICPE), Groningen, the Netherlands.

Background: The locus of control (LOC) construct has been associated with onset, course, and severity of anxiety and depression. We investigated the stability of LOC, the bidirectional relationships between LOC and symptom severity of anxiety and depression over nine years, and the influence of intermediate positive and negative life-events on these associations.

Methods: Data came from five assessment waves over nine years of 2052 subjects with an anxiety or depressive disorder or healthy controls. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.005DOI Listing

What is the combined effect of intense intermittent exercise and Ginkgo biloba plant on the brain neurotrophic factors levels, and learning and memory in young rats?

Pharmacol Rep 2019 Feb 12;71(3):503-508. Epub 2019 Feb 12.

Neuroscience Research Center, Department of Physical Education, School of Medicine, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Background: The present study was conducted to investigate the effect of intense intermittent exercise and Ginkgo biloba on the hippocampal levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and also memory and learning in young rats.

Methods: Forty two eight-week-old rats were randomly divided into six groups including control, low dose of Ginkgo biloba (65 mg/kg), high dose of Ginkgo biloba (100 mg/kg), exercise, exercise + low dose of Ginkgo biloba, exercise + high dose of Ginkgo biloba. The exercise protocol or Ginkgo biloba administration was six days a week for six weeks. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.006DOI Listing
February 2019

Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.

Leuk Res 2019 Apr 13;81:43-49. Epub 2019 Apr 13.

University of Colorado Division of Hematology, Aurora, CO, United States. Electronic address:

Background: Patients with relapsed and refractory (R/R) acute myeloid leukemia (AML) have limited treatment options. Genomically-defined personalized therapies are only applicable for a minority of patients. Therapies without identifiable targets can be effective but patient selection is challenging. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.04.005DOI Listing

The non-anticoagulant promise of heparin and its mimetics.

Authors:
Barbara Mulloy

Curr Opin Pharmacol 2019 Apr 19;46:50-54. Epub 2019 Apr 19.

Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London, SE1 9NH, UK. Electronic address:

Heparin, the widely used anticoagulant and antithrombotic polysaccharide, has other potential therapeutic uses that arise from its similarity to heparan sulfate. This review provides a brief overview of the most recent developments in this field, paying particular respect to pulmonary and respiratory pharmacology. It has often been said that heparin, with its mimetics and derivatives, shows great promise in the treatment of inflammatory, infectious, and malignant conditions. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.009DOI Listing

In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations.

Int J Parasitol Drugs Drug Resist 2019 Apr 10;10:20-27. Epub 2019 Apr 10.

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, 650500, China. Electronic address:

Mutations in the Kelch domain of the K13 gene (PF3D7_1343700) were previously associated with artemisinin resistance in Plasmodium falciparum. This study followed the dynamics of the K13 polymorphisms in P. falciparum parasites from the China-Myanmar border area obtained in 2007-2016, and their in vitro sensitivities to artesunate (AS) and dihydroartemisinin (DHA). Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.04.002DOI Listing

Optimal Lymph Nodes Examination and Adjuvant Chemotherapy for Stage I Lung Cancer.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University, Shanghai, China. Electronic address:

Purpose: To determine the optimal number of lymph nodes (LNs) examined and role of adjuvant chemotherapy in stage I lung cancer.

Methods: The National Cancer Database was queried for surgically-treated patients with pathologic stage I lung cancer between 2006 and 2014 (n=65,438). The optimal LN numbers were determined in the multivariate Cox model, and were further validated in clinical stage I cohort (n=117,112) in terms of nodal upstaging and prognostic stratification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193029
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http://dx.doi.org/10.1016/j.jtho.2019.03.027DOI Listing
April 2019
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Efficacy of live attenuated vaccine derived from the Streptococcus agalactiae on the immune responses of Oreochromis niloticus.

Fish Shellfish Immunol 2019 Apr 19. Epub 2019 Apr 19.

School of Fisheries and Aquaculture Sciences, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia; Institute of Tropical Aquaculture, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.

Streptococcus agalactiae species have been recognized as the main pathogen causing high mortality in fish leading to significant worldwide economical losses to the aquaculture industries. Vaccine development has become a priority in combating multidrug resistance in bacteria; however, there is a lack of commercial live attenuated vaccine (LAV) against S. agalactiae in Malaysia. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.052DOI Listing

An Imbalance of T Cell Subgroups Exists in Children with Sepsis.

Microbes Infect 2019 Apr 19. Epub 2019 Apr 19.

Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China. Electronic address:

The purpose of this study is to explore the role of different T cell subgroups in the pathogenesis of sepsis in children. Flow cytometry was used to detect the changes in the activation status and the number of T cell subgroups in the peripheral blood of children with sepsis; healthy children were selected as the control group. Compared with healthy children, the number of CD4+ T cells in the peripheral blood of children with sepsis did not change significantly (Z = 1. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.04.002DOI Listing

Validation of a simple screening test for elementary visuo-spatial perception deficit.

Ann Phys Rehabil Med 2019 Apr 19. Epub 2019 Apr 19.

Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de Rééducation Pédiatrique, Bron, France.

Objective: The reliability and validity of a screening test for a deficit in elementary visuo-spatial perception (EVSP) were evaluated.

Method: This prospective study collected performance from 210 typically-developing individuals and evaluated the internal consistency of the EVSP screening test. Test-retest reliability was examined with 25 individuals. Read More

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http://dx.doi.org/10.1016/j.rehab.2019.03.006DOI Listing

Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Div of Pediatrics, Dept of Clinical and Experimental Medicine, Linköping university SE 58185 Linköping, Sweden; Crown Princess Victoria Children´s Hospital, Region Östergötland, Linköping, Sweden.

Background & Aims: Functional gastrointestinal disorders are highly prevalent, cause significant suffering, and are costly to society. Pain is a central feature of 2 of the most common functional gastrointestinal disorders-irritable bowel syndrome and functional dyspepsia. Although these disorders have been well studied in adults, their etiology is poorly understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.036DOI Listing
April 2019
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Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Upper Gastrointestinal Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background & Aims: Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.

Methods: The National Diabetes Register contains data on about 90% of persons in Sweden with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.038DOI Listing

Should We Divide Crohn's Disease Into Ileum-dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

University of California San Diego, La Jolla CA.

Crohn's disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing
April 2019
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One-stage Surgical Treatment for Consecutive Multi-segment Thoracic Spinal Tuberculosis with Kyphosis by Posterior-only Debridement, Interbody Fusion and Instrumentation.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China. Electronic address:

Objective: To evaluate the clinical efficacy and feasibility of one-stage surgical treatment for consecutive multi-segment thoracic spinal tuberculosis with kyphosis by posterior-only debridement, interbody fusion and instrumentation.

Methods: Sixty-two patients who underwent posterior debridement, interbody fusion and instrumentation were reviewed for radiographic fusion, region kyphosis, neurological status and clinical outcomes. Thoracic Cobb's angle and Frankel grading system were employed to assess kyphosis and neurological improvements, respectively. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.122DOI Listing

Case Report; Safety And Efficacy Of Mechanical Thrombectomy In Two Cases Of Acute Ischemic Stroke In Centennial Patients.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA. Electronic address:

Background: and Importance: Mechanical thrombectomy (MT) became a standard of care for stroke patients after the positive results of five randomized trials in 2015. However, elderly patients > 65 were excluded from those trials. Recent studies and clinical trials examining the efficacy of MT in patients over the age of 85 have shown that good outcomes can be achieved with careful patient selection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193111
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http://dx.doi.org/10.1016/j.wneu.2019.04.123DOI Listing
April 2019
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Revisiting the middle cluneal nerves: an anatomical study with application to pain syndromes and invasive procedures around the sacrum.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Seattle Science Foundation, Seattle, WA, USA; Department of Anatomical Sciences, St. George's University, St. George's, Grenada, West Indies.

Objective: The middle cluneal nerves (MCNs) are stated to arise from the sacral dorsal rami of S1 to S3 and supply the gluteal skin, but their detailed anatomy is unclear and often variably depicted and described. Therefore, the goal of this study was to revisit the anatomy of the MCNs and provide a clearer picture of their morphology.

Methods: Five fresh-frozen Caucasian cadavers (10 sides) (two males and three females) were dissected for this study. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.109DOI Listing

Indications for Mechanical Thrombectomy Too Wide or Too Narrow?

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

The indications for mechanical thrombectomy (MT) have expanded since the American Heart Association/American Stroke Association (AHA/ASA) published its first guideline on MT in 2013. Multiple subsequent randomized clinical trials of MT have proven its efficacy, including the DAWN and DEFUSE 3 trials. The current guideline from AHA/ASA provides Class I support for the use of MT for the following indications: 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.116DOI Listing

The Utility of MRI Results in Physician Decision Making Prior to Initial Lumbar Spinal Injection.

Spine J 2019 Apr 19. Epub 2019 Apr 19.

University of Colorado Department of Physical Medicine and Rehabilitation, 12631 E. 17th Avenue, Mail Stop F493, Academic Office 1 (AO1), Room 2510, Aurora, Colorado 80045, US.

Background Context: The need for advanced imaging prior to spinal intervention is an area of ongoing debate. Many studies have demonstrated the accuracy of MRI results in evaluating structural pathology in the lumbar spine, but few have addressed how frequently MRI findings change clinical management. A randomized controlled trial showed that viewing MRI results did not impact outcomes in patients with radiculopathy undergoing epidural steroid injection (ESI). Read More

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http://dx.doi.org/10.1016/j.spinee.2019.04.016DOI Listing

Oxytocin Effects on Pain Perception and Pain Anticipation.

J Pain 2019 Apr 19. Epub 2019 Apr 19.

Department of General Psychiatry, University Hospital of Heidelberg, 69115 Heidelberg.

There is an ongoing debate whether the neuropeptide oxytocin (OT) modulates pain processing in humans. This study differentiates behavioral and neuronal OT effects on pain perception and pain anticipation by using a Pavlovian conditioning paradigm. Forty-six males received intranasally administered OT in a randomized double-blind, placebo-controlled group design. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.002DOI Listing

In vivo and in vitro bioactivity of a "precursor of apatite" treatment on polyetheretherketone.

Acta Biomater 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We recently developed a surface treatment, "precursor of apatite" (PrA), for polyetheretherketone (PrA-PEEK) via a simple, low-temperature process aiming to achieve stronger and faster adhesion to bone. The treatment involves three steps: HSO immersion, exposure to O plasma discharge, and alkaline simulated body fluid (alkaline SBF) treatment. This method produces homogeneous fine particles of amorphous calcium phosphate on the PEEK, and we confirmed that PrA-PEEK had excellent apatite formation ability in an SBF immersion test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193028
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http://dx.doi.org/10.1016/j.actbio.2019.04.041DOI Listing
April 2019
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Eight weeks of static apnea training increases spleen volume but not acute spleen contraction.

Respir Physiol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, 9000 Ghent, Belgium. Electronic address:

Splenic contraction is an important response to acute apnea causing the release of red blood cells into blood circulation. Current literature shows higher spleen volumes and greater spleen contractions in trained apnea divers compared to untrained individuals, but the influence of training is presently unknown. Thirteen subjects daily performed five static apneas for 8 weeks. Read More

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http://dx.doi.org/10.1016/j.resp.2019.04.002DOI Listing

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Mitochondrion 2019 Apr 19. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirometry, Western blot and enzymatic analyses in skin fibroblasts support the pathogenicity of the m. Read More

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http://dx.doi.org/10.1016/j.mito.2019.04.004DOI Listing

Urinary and Sexual Outcomes following Bulbar Urethroplasty - An Analysis of Two Common Approaches.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Clinical Professor of Urology, University of California - Irvine, Department of Urology, 333 City Blvd West, Suite 1240, Orange, CA 92868. Electronic address:

Objective: To report success and patient reported urinary and sexual outcomes of patients who underwent anastomotic urethroplasty and dorsal buccal onlay urethroplasty.

Materials And Methods: Patients who underwent primary transecting anastomotic or dorsal buccal onlay urethroplasty for bulbar strictures at our institution between 1998 and 2015 were analyzed. Patients who had a prior urethroplasty, involvement of a different portion of the urethra, or a diagnosis of LS or hypospadias were excluded. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.042DOI Listing

International and Multi-Institutional Assessment of Factors Associated with Performance and Quality of Lymph Node Dissection during Radical Nephrectomy.

Urology 2019 Apr 19. Epub 2019 Apr 19.

University of Texas, Austin, TX, USA. Electronic address:

Objective: To determine factors associated with performance and quality of lymph node dissection during radical nephrectomy.

Materials And Methods: Using an international data registry, we performed multilevel logistic regression to determine the association of surgical approach (open surgery vs. minimally invasive surgery), institutional experience (low, moderate and high tertiles), and institutional preference (minimally invasive surgery, balanced, and open surgery tertiles) with the performance of lymph node dissection in subgroups by clinical stage and nodal status. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.068DOI Listing

A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

Reappraisal of probiotics' safety in human.

Food Chem Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Contrary to the safe usage of probiotics for years, their threat is still worthy of attention. Several risks have been explained or mentioned in the case reports, clinical trials and experimental studies. Due to a large number of probiotic products worldwide, the certainty of the safety of such products is a matter of concern. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.032DOI Listing
April 2019
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Demystifying the Use of Self Expandable Interwoven Nitinol Stents in Femoropopliteal Peripheral Arterial Disease.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

The Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK,. Electronic address:

Femoropopliteal atherosclerosis affects a significant percentage of the world population leading to intermittent claudication and critical limb ischemia. The femoropopliteal segment has a unique set of biomechanical challenges that must be considered and overcome for treatment. The use of stents is a reality and a necessity in peripheral interventions. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.014DOI Listing

SINGLE-CENTER EXPERIENCE IN THE TREATMENT OF VISCERAL ARTERY ANEURYSMS.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular Surgery - Policlinico Umberto I°; "Sapienza" University - Rome.

Aims: Visceral artery aneurysms (VAAs), although rare, represent a life-threatening disease with high mortality rates. With the more frequent use of diagnostic tests, there has been an incidental detection of these lesions which are mostly asymptomatic. It follows that surgeons are increasingly called to decide the most appropriate management of VAAs between an open surgical or endovascular approach and among the different endovascular options currently available. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.010DOI Listing

The Application of Virtual Reality in Patient Education.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Division of Vascular Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA. Electronic address:

Background: Virtual reality (VR) provides an immersive image viewing experience that has recently been expanding in use in clinical medicine. We developed a three-dimensional (3D) model of an abdominal aortic aneurysm (AAA) for patients with a diagnosis of an AAA to view in VR to assess the utility of VR in patient education.

Materials And Methods: This was a cross-sectional study using an educational intervention. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.015DOI Listing

Splenic Infarct After Warfarin Overdose Treatment; Is it coincidence or complication?

Authors:
Gökhan Yilmaz

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Specialist, Emergency Medicine Clinic, Kayseri Training and Research Hospital, Kayseri, Turkey. Electronic address:

The Splenic infarct is a rare clinical condition seen in the emergency department and can mimic acute abdomen. Hematologic, vascular and thromboembolic events are considered in the etiology. Treatment options are varying between symptomatic treatment and splenectomy. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.02.012DOI Listing

Two-Year Outcomes of Early Cannulation Arteriovenous Grafts for End Stage Renal Disease.

Authors:
Sapan S Desai

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Director of Performance Improvement, Northwest Community Healthcare, Arlington Heights, IL 60005. Electronic address:

Introduction: Almost 80% of patients with end stage renal disease (ESRD) initiate dialysis via a central venous catheter (CVC). CVCs are associated with multiple complications and a high cost of care. The purpose of our project is to determine the impact of early cannulation arteriovenous grafts (ECAVGs) on quality of care and costs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096193023
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http://dx.doi.org/10.1016/j.avsg.2019.02.007DOI Listing
April 2019
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