1,050 results match your criteria Clinical Colorectal Cancer[Journal]


A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Clin Colorectal Cancer 2019 Mar 7. Epub 2019 Mar 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; University of Turin, Department of Oncology, Candiolo (TO), Italy. Electronic address:

Background: The diagnosis of colorectal cancer (CRC) is routinely accomplished through histopathologic examination. Prognostic information and treatment decisions are mainly determined by TNM classification, first defined in 1968. In the last decade, patient-specific CRC genomic landscapes were shown to provide important prognostic and predictive information. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.008DOI Listing

Lack of Benefit From Anti-EGFR Treatment in RAS and BRAF Wild-type Metastatic Colorectal Cancer With Mucinous Histology or Mucinous Component.

Clin Colorectal Cancer 2019 Mar 7. Epub 2019 Mar 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

Background: Adenocarcinoma with mucinous histology or mucinous component are histologic subtypes of metastatic colorectal cancers (mCRCs) with limited benefit from cytotoxic agents. Their sensitivity to anti-epithelial growth factor receptors (EGFRs) is not clear.

Patients And Methods: The activity and efficacy of anti-EGFRs was retrospectively evaluated among patients with RAS and BRAF wild-type mCRC with or without mucinous histology or mucinous component. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.007DOI Listing

Tumor Heterogeneity as a Predictor of Response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer.

Clin Colorectal Cancer 2019 Feb 13. Epub 2019 Feb 13.

Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM. Electronic address:

Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard of care for locally advanced adenocarcinoma of the rectum, but it is currently unknown which patients have disease that will respond. This study tested the correlation between response to nCRT and intratumoral heterogeneity using next-generation sequencing assays.

Patients And Methods: DNA was extracted from formalin-fixed, paraffin-embedded biopsy samples from a cohort of patients with locally advanced rectal adenocarcinoma (T3/4 or N1/2 disease) who received nCRT. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.003DOI Listing
February 2019
3 Reads

Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer.

Clin Colorectal Cancer 2019 Feb 10. Epub 2019 Feb 10.

Department of Surgery & Cancer, Imperial College London, London, UK; St Mark's Hospital and Academic Institute, Harrow, London, UK. Electronic address:

Preoperative radiotherapy (RT) plays an important role in the management of locally advanced rectal cancer (RC). Tumor regression after RT shows marked variability, and robust molecular methods are needed to help predict likely response. The aim of this study was to review the current published literature and use Gene Ontology (GO) analysis to define key molecular biomarkers governing radiation response in RC. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.004DOI Listing
February 2019
1 Read

Survival Outcomes After Surgical Management of the Primary Tumor With and Without Radiotherapy for Metastatic Rectal Adenocarcinoma: A National Cancer Database (NCDB) Analysis.

Clin Colorectal Cancer 2019 Feb 5. Epub 2019 Feb 5.

Division of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA.

Background: With advances in systemic therapies, the role of primary tumor resection may be of increased importance in patients with metastatic rectal cancer. The role of combining pelvic radiotherapy with surgical resection in the metastatic setting is unknown. We utilized the National Cancer Database to examine outcomes in patients with metastatic rectal adenocarcinoma with primary tumor resection with and without pelvic radiotherapy. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.12.005DOI Listing
February 2019

Biologics, Immunotherapy, and Future Directions in the Treatment of Advanced Cholangiocarcinoma.

Clin Colorectal Cancer 2019 Feb 27. Epub 2019 Feb 27.

Division of Medical Oncology, Department of Medicine, Kansas University Cancer Center, Westwood, KS.

Gemcitabine plus cisplatin remains the standard first-line systemic therapy for advanced cholangiocarcinoma and offers a median survival of approximately 1 year. No standard regimens beyond the first line and no targeted or immunotherapy agents are approved yet in this disease. Development of molecular targeted therapy in this heterogenous and relatively rare malignancy continues to be a challenging area. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.005DOI Listing
February 2019
1 Read
2.907 Impact Factor

FOLFOX and FOLFIRI Use in Stage IV Colon Cancer: Analysis of SEER-Medicare Data.

Clin Colorectal Cancer 2019 Jan 31. Epub 2019 Jan 31.

Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.

Background: Shortly after the year 2000, randomized trials demonstrated that patients with metastatic colon cancer treated with infusional 5-fluorouracil (5-FU)/leucovorin with either oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) had a comparable progression-free survival benefit, superior to patients who received 5-FU/leucovorin alone. Factors associated with the initial receipt of the FOLFOX or FOLFIRI regimen are unknown. Our goal was to investigate the patterns and predictors of use for first-line FOLFOX and FOLFIRI. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.005DOI Listing
January 2019

Colon Cancer Tumor Location Defined by Gene Expression May Disagree With Anatomic Tumor Location.

Clin Colorectal Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN. Electronic address:

Background: Cancers of the right colon have been shown to differ from left-side colon cancers in prognosis, response to epithelial growth factor receptor inhibitors, microsatellite instability and BRAF mutation status, and other molecular characteristics. Clinical application of these differences will benefit from a deeper understanding of how tumor location defines and is defined by gene expression.

Materials And Methods: This study was carried out using Affymetrix microarray datasets (Cohort A: training set, n = 352; validation set, n = 519) and samples from The Cancer Genome Atlas Colon Adenocarcinoma database (Cohort B: n = 408), in which tumor location was reported. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.002DOI Listing
February 2019
2 Reads

A Review on the Scope of Photothermal Therapy-Based Nanomedicines in Preclinical Models of Colorectal Cancer.

Clin Colorectal Cancer 2019 Feb 14. Epub 2019 Feb 14.

School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.

Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.001DOI Listing
February 2019
3 Reads

Phase II Study of Tivantinib and Cetuximab in Patients With KRAS Wild-type Metastatic Colorectal Cancer With Acquired Resistance to EGFR Inhibitors and Emergence of MET Overexpression: Lesson Learned for Future Trials With EGFR/MET Dual Inhibition.

Clin Colorectal Cancer 2019 Feb 14. Epub 2019 Feb 14.

Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Background: MET overexpression/amplification has been associated with resistance to anti- epidermal growth factor receptor therapies in patients with metastatic colorectal cancer (mCRC). Combining tivantinib, an inhibitor of the MET receptor tyrosine kinase, and cetuximab may be effective in patients with epidermal growth factor receptor-resistant MET-high mCRC.

Patients And Methods: This multicenter, single-arm, Simon 2-stage, phase II study enrolled patients with MET-high, KRAS wild-type mCRC, who were treated with ≥ 1 prior systemic therapy, with at least stable disease on the last treatment regimen containing cetuximab or panitumumab. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.02.004DOI Listing
February 2019
1 Read

Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery.

Clin Colorectal Cancer 2019 Jan 29. Epub 2019 Jan 29.

Head Surgery Unit, Clinical Sciences Department, College of Medicine University of Sharjah, Sharjah, United Arab Emirates. Electronic address:

Surgery remains the mainstay of curative treatment for colorectal cancer (CRC). Despite curative surgery, some patients experience cancer recurrence. However, the pattern, stage, and time of recurrent disease (RD) remain unknown. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.003DOI Listing
January 2019

Disqualification of Neoadjuvant Rectal Score Based on Data of 6596 Patients From the Netherlands Cancer Registry.

Clin Colorectal Cancer 2019 Jan 19. Epub 2019 Jan 19.

Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background: The neoadjuvant rectal score (NAR) was developed as a surrogate endpoint for overall survival in patients with rectal cancer after neoadjuvant treatment. We aimed to validate the NAR score in patients from the Netherlands Cancer Registry database.

Patients And Methods: We studied patients with rectal cancer treated with long-course neoadjuvant therapy followed by surgery in the Netherlands between 2007 and 2014. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.001DOI Listing
January 2019
3 Reads

Right or Left Primary Site of Colorectal Cancer: Outcomes From the Molecular Analysis of the AGITG MAX Trial.

Clin Colorectal Cancer 2019 Jan 3. Epub 2019 Jan 3.

Department of Medical Oncology, The Queen Elizabeth Hospital, Adelaide, Australia; University of Adelaide, Adelaide, Australia; Basil Hetzel Institute, Woodville, Australia.

Background: For metastatic colorectal cancer, previous reports have described differences in biology and outcome, including response to biologic agents, based on whether the primary tumor is right- or left-sided. We explored the molecular markers from the AGITG MAX trial.

Patients And Methods: The AGITG MAX trial was a randomized study comparing capecitabine versus capecitabine + bevacizumab versus capecitabine + bevacizumab + mitomycin C as first-line therapy in advanced colorectal cancer. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.12.002DOI Listing
January 2019
2.907 Impact Factor

Trends in Colorectal Cancer Incidence and Survival in Iowa SEER Data: The Timing of It All.

Clin Colorectal Cancer 2018 Dec 22. Epub 2018 Dec 22.

National Institute of Environmental Health Sciences, Durham, NC.

Background: Colorectal cancer (CRC) is common worldwide, with 140,250 diagnoses and 50,630 deaths estimated for the United States in 2018. Guidelines current to the most recent individuals in our analysis suggested regular screenings beginning at age 50 have reduced the incidence of CRC. However, the incidence continues to rise among those under 50. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.12.001DOI Listing
December 2018

Impact of Sex on Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer: Pooled Analysis of 5 Randomized Trials.

Clin Colorectal Cancer 2018 Dec 28. Epub 2018 Dec 28.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Electronic address:

Purpose: To evaluate the impact of sex on toxicity and efficacy outcomes among patients with metastatic colorectal cancer receiving first-line 5-fluorouracil-based regimens.

Patients And Methods: A pooled analysis of data sets from 5 clinical trials (NCT00115765, NCT00364013, NCT00272051, NCT00305188, NCT00384176) was performed. Kaplan-Meier analysis and log-rank testing were used to assess the differences in overall and progression-free survival between male and female subjects. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.12.006DOI Listing
December 2018
1 Read
2.907 Impact Factor

Tumor-associated Macrophages and Neuroendocrine Differentiation Decrease the Efficacy of Bevacizumab Plus Chemotherapy in Patients With Advanced Colorectal Cancer.

Clin Colorectal Cancer 2018 Dec 27. Epub 2018 Dec 27.

Department of Medical Oncology, Ankara University School of Medicine, Ankara, Turkey. Electronic address:

Background: In the present study, we investigated the prognostic and predictive role of neuroendocrine differentiation (NED) and tumor-associated macrophage (TAM) infiltration in tumor tissue from patients with advanced colorectal cancer who had received bevacizumab plus chemotherapy.

Patients And Methods: A total of 123 consecutive patients with advanced colorectal cancer who had received bevacizumab plus irinotecan/oxaliplatin-based combination chemotherapy were included in the present study. In addition to the clinicopathologic parameters, the presence of NED and the level of TAM infiltration were studied as covariates for survival analysis. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.12.004DOI Listing
December 2018
3 Reads

Neuroendocrine Differentiation, Microsatellite Instability, and Tumor-infiltrating Lymphocytes in Advanced Colorectal Cancer With BRAF Mutation.

Clin Colorectal Cancer 2018 Dec 20. Epub 2018 Dec 20.

Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Research Center for the Study of Hereditary and Familial Tumors, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Background: Approximately 10% of metastatic colorectal cancer (mCRC) cases will harbor the BRAF p.V600E mutation (BRAF-mCRC) and have been associated with a poor prognosis. Although they are usually considered a unique clinical entity, biologic heterogeneity has been described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183043
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http://dx.doi.org/10.1016/j.clcc.2018.12.003DOI Listing
December 2018
10 Reads

Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study.

Clin Colorectal Cancer 2019 03 29;18(1):e150-e162. Epub 2018 Nov 29.

Univ Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, Bordeaux, France; Bordeaux PharmacoEpi, INSERM CIC1401, Bordeaux, France; CHU de Bordeaux, Pôle de Sante publique, Service de Pharmacologie médicale, Bordeaux, France.

Background: Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Their real-life evaluation is insufficient, especially in elderly and frail patients. The aim was to describe use, safety, and effectiveness of targeted therapies in first-line mCRC treatment according to age. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.005DOI Listing
March 2019
3 Reads

Review: Pathology and Its Clinical Relevance of Mucinous Appendiceal Neoplasms and Pseudomyxoma Peritonei.

Clin Colorectal Cancer 2019 03 6;18(1):1-7. Epub 2018 Dec 6.

Department of Pathology, Laboratory for Pathology and Medical Microbiology (PAMM), Eindhoven, the Netherlands.

Until recently, many classifications existed for the terminology and histopathologic classification of appendiceal mucinous neoplasms, mucinous appendiceal adenocarcinomas, and pseudomyxoma peritonei (PMP). A major accomplishment was achieved by consensus-based histopathologic classifications on behalf of the Peritoneal Surface Oncology Group International regarding mucinous appendiceal tumours and PMP. As different classifications were used over the years and also owing to the rare nature of these tumors, many clinicians are not familiar with the terminology and the impact on patient management. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.007DOI Listing
March 2019
2 Reads

Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice.

Clin Colorectal Cancer 2019 03 16;18(1):e117-e129. Epub 2018 Nov 16.

Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University Vienna, Vienna, Austria. Electronic address:

An increasing number of patients with metastatic colorectal cancer (mCRC) are able to receive 3 or more lines of therapy. Treatments in this setting can include regorafenib (an oral multikinase inhibitor), trifluridine/tipiracil hydrochloride (TAS-102), antibodies that target epidermal growth factor receptor for patients with RAS wild-type tumors (if no prior exposure), and, where approved, anti-programmed cell death protein 1 inhibitors for patients with microsatellite instability-high mCRC. Although guidelines describe the available treatment options, few insights are provided to guide selection and sequencing. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.002DOI Listing
March 2019
1 Read

Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20.

Clin Colorectal Cancer 2019 03 28;18(1):e140-e149. Epub 2018 Nov 28.

Canadian Cancer Trials Group, Kingston, Canada.

Background: The safety and efficacy of targeted therapy in older patients (≥ 70 years) with metastatic colorectal cancer is not well evaluated.

Patients And Methods: Outcomes of older patients (including overall survival [OS], progression-free survival [PFS], toxicity, and quality of life [QoL]) were compared to young patients using data from 2 large previously reported clinical trials, CO.17 (cetuximab vs. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.006DOI Listing
March 2019
2 Reads
2.907 Impact Factor

Pathologic Staging Inconsistency Between ypT4N0 (stage II) and ypT1-2N1 (stage III) After Preoperative Chemoradiotherapy and Total Mesorectal Excision in Rectal Cancer: A Multi-Institutional Study.

Clin Colorectal Cancer 2019 03 23;18(1):e130-e139. Epub 2018 Nov 23.

Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: In the Surveillance, Epidemiology, and End Results population-based data, the survival curves reversed between T4N0 (stages IIB or IIC) and T1-2N1 (stage IIIA) in rectal cancer. However, T4N0 had a higher stage than T1-2N1 in the current colorectal staging system.

Patients And Methods: We analyzed 1804 patients with rectal cancer who were treated with preoperative chemoradiotherapy and curative surgery. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.003DOI Listing
March 2019
7 Reads

Perioperative Bevacizumab-based Triplet Chemotherapy in Patients With Potentially Resectable Colorectal Cancer Liver Metastases.

Clin Colorectal Cancer 2019 03 24;18(1):34-43.e6. Epub 2018 Nov 24.

Oncology and Hemato-Oncology Department, University of Milan, Milan, Italy; General Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: In colorectal cancer liver metastases (CRCLM), bevacizumab-based neoadjuvant strategies provide increased pathologic response. We aimed at assessing the activity of perioperative capecitabine, oxaliplatin, irinotecan, and bevacizumab (COI-B regimen) in patients with potentially resectable CRCLM, and investigating biomarkers for early prediction of pathologic response.

Patients And Methods: This was a single-center phase II study enrolling patients with liver-limited, borderline resectable disease and/or high-risk features. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.11.004DOI Listing
March 2019
5 Reads

Effects of Proton Pump Inhibitors on FOLFOX and CapeOx Regimens in Colorectal Cancer.

Clin Colorectal Cancer 2019 03 16;18(1):72-79. Epub 2018 Nov 16.

Department of Medical Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada. Electronic address:

Background: First-line adjuvant chemotherapy options for early-stage colorectal cancer (CRC) include CapeOx (capecitabine, intravenous oxaliplatin) and FOLFOX (intravenous 5-fluorouracil, leucovorin, oxaliplatin). Capecitabine is an oral prodrug analog of 5-fluorouracil, and recent studies have suggested that proton pump inhibitors (PPIs) may detrimentally affect capecitabine efficacy. Conversely, some literature suggests that PPIs may negatively affect CRC itself. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183045
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http://dx.doi.org/10.1016/j.clcc.2018.11.001DOI Listing
March 2019
14 Reads
2.907 Impact Factor

5-Fluorouracil-related Cardiotoxicity; Findings From Five Randomized Studies of 5-Fluorouracil-based Regimens in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2019 03 1;18(1):58-63. Epub 2018 Nov 1.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Electronic address:

Background: 5-Fluorouracil (5-FU) represents the backbone of systemic therapy regimens of colorectal cancer. The current study aims at evaluating the patterns and predictors of cardiac adverse events associated with various 5-FU-based systemic therapy regimens among patients with metastatic colorectal cancer.

Materials And Methods: This pooled analysis includes de-identified patient-level datasets from 5 randomized studies (NCT00272051, NCT00305188, NCT00115765, NCT00364013, and NCT00384176). Read More

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http://dx.doi.org/10.1016/j.clcc.2018.10.006DOI Listing
March 2019
14 Reads
2.907 Impact Factor

Cetuximab Alone or With Irinotecan for Resistant KRAS-, NRAS-, BRAF- and PIK3CA-wild-type Metastatic Colorectal Cancer: The AGITG Randomized Phase II ICECREAM Study.

Clin Colorectal Cancer 2018 12 8;17(4):313-319. Epub 2018 Jun 8.

Department of Oncology, Monash Health and Monash University, Clayton, Victoria, Australia.

Background: The Irinotecan Cetuximab Evaluation and Cetuximab Response Evaluation (ICECREAM) study assessed the efficacy of cetuximab monotherapy compared with cetuximab combined with chemotherapy for quadruple wild-type (KRAS, NRAS, BRAF, or P13KCA exon 20) metastatic colorectal cancer.

Patients And Methods: Patients were enrolled in an open-label, multicenter, phase II trial and randomly assigned to cetuximab 400 mg/m, then 250 mg/m cetuximab weekly, with or without irinotecan 180 mg/m every 2 weeks. The primary endpoint was 6-month progression-free survival; secondary endpoints were response rate, overall survival, toxicity, and quality of life. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.06.002DOI Listing
December 2018
22 Reads
2.907 Impact Factor

Plasma Dynamics of RAS/RAF Mutations in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy and Anti-EGFR Treatment.

Clin Colorectal Cancer 2019 03 24;18(1):28-33.e3. Epub 2018 Oct 24.

Danish Colorectal Cancer Center South, Vejle Hospital, Vejle, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.

Background: RAS and RAF mutations in colorectal cancer (CRC) hold value in precision medicine. Liquid biopsy is an alternative to tumor tissue biopsy, and circulating tumor DNA (ctDNA) has been intensively investigated, but the clinical relevance of RAS and RAF mutations in plasma is yet to be determined. This study aimed to investigate the clinical aspects of RAS/RAF mutations during combination treatment. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.10.004DOI Listing
March 2019
17 Reads

Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER-Based Analysis.

Clin Colorectal Cancer 2019 03 27;18(1):e104-e116. Epub 2018 Oct 27.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Background: The prognostic value of tumor sidedness in metastatic colorectal cancer (CRC) has been established, but its impact on nonmetastatic disease remains unclear. Our study aimed to explore the prognostic effect of tumor sidedness by subgroup survival analyses, according to histology and tumor grade in stage I-IV CRCs.

Methods: A retrospective population-based study was conducted based on Surveillance, Epidemiology and End Results (SEER) data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183045
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http://dx.doi.org/10.1016/j.clcc.2018.10.005DOI Listing
March 2019
19 Reads

Rising Proportion of Young Individuals With Rectal and Colon Cancer.

Clin Colorectal Cancer 2019 03 17;18(1):e87-e95. Epub 2018 Oct 17.

Division of Colon and Rectal Surgery, Mayo Clinic, Jacksonville, FL.

Background: Recent trends have identified increasing number of young individuals with rectal and colon cancers. These individuals, who are younger than 50 years old, in most instances would not meet screening guidelines. We aimed to report the characteristics and trend of the rising proportion of young individuals being diagnosed with rectal and colon cancers at our institutions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183040
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http://dx.doi.org/10.1016/j.clcc.2018.10.002DOI Listing
March 2019
21 Reads

Rising Incidence and Improved Survival of Anal Squamous Cell Carcinoma in Norway, 1987-2016.

Clin Colorectal Cancer 2019 03 16;18(1):e96-e103. Epub 2018 Oct 16.

Department of Registration, Cancer Registry of Norway, Oslo, Norway.

Background: Anal squamous cell carcinoma (ASCC) is a rare, human papilloma virus-associated cancer. The purpose was to investigate the population-based incidence rates, age and gender distribution, and survival of ASCC.

Materials And Methods: All primary ASCC in 1987 to 2016 were identified in the Cancer Registry of Norway (N = 1548), with information on age, gender, stage, county of residence, radiotherapy, and survival. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183030
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http://dx.doi.org/10.1016/j.clcc.2018.10.001DOI Listing
March 2019
11 Reads

E-Cadherin in Colorectal Cancer: Relation to Chemosensitivity.

Clin Colorectal Cancer 2019 03 16;18(1):e74-e86. Epub 2018 Oct 16.

Privolzhsky Research Medical University (PRMU), Nizhny Novgorod, Russia.

Background: The conventional chemotherapy of colorectal cancer with irinotecan, 5-fluorouracil, and oxaliplatin remains one of the front-line treatments worldwide. However, its efficacy is quite low. Recently studies of the epithelial-mesenchymal transition (EMT) have become the focus of investigations into the cause of chemoresistance in several types of cancer, including colorectal cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028173049
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http://dx.doi.org/10.1016/j.clcc.2018.10.003DOI Listing
March 2019
16 Reads

Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High-Risk Stage III (pT4 and/or N2) Colon Cancer-A UNICANCER GI-PRODIGE Trial.

Clin Colorectal Cancer 2019 03 19;18(1):e69-e73. Epub 2018 Oct 19.

Sorbonne Paris Cité, Paris Decartes University; Hôpital Européen Georges-Pompidou, Paris, France.

Background: According to the IDEA trial, 6-month adjuvant chemotherapy should remain the treatment standard in stage III T4 or N2 colon cancer. The relatively poor survival in this high-risk subgroup-a 3-year disease-free survival (DFS) rate of 65%-and the potential synergistic efficacy of 5-fluorouracil (5-FU), oxaliplatin, and irinotecan suggest that FOLFIRINOX may be a regimen of particular interest in this setting.

Patients And Methods: This multicenter international phase 3 trial (ClinicalTrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183025
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http://dx.doi.org/10.1016/j.clcc.2018.09.011DOI Listing
March 2019
19 Reads

Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.

Clin Colorectal Cancer 2019 03 29;18(1):64-71.e1. Epub 2018 Sep 29.

Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK. Electronic address:

Background: Gastrointestinal (GI) cancer patients may not be considered for therapy with fluoropyrimidines (FPs) because of previous cardiovascular (CV) toxicity or preexisting risk factors; such patients may benefit from raltitrexed-based therapy.

Patients And Methods: Patient, tumor, and treatment characteristics, as well as clinical outcomes of all consecutively treated patients with raltitrexed at the Royal Marsden Hospital between October 1998 and July 2011 were examined. GI cancer patients who developed CV toxicity as a result of FPs and those with significant CV risk factors receiving raltitrexed were included in this analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183021
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http://dx.doi.org/10.1016/j.clcc.2018.09.010DOI Listing
March 2019
9 Reads

Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine.

Clin Colorectal Cancer 2019 03 10;18(1):52-57. Epub 2018 Oct 10.

Department of Medical Oncology, Mayo Clinic, Rochester, MN.

Introduction: Coronary vasospasm associated with fluoropyrimidine (FP)-based chemotherapy is a potentially serious complication and reported to occur more often with infusional 5-fluorouracil (5-FU) or capecitabine than with bolus 5-FU. Given the additional benefit of oxaliplatin over FP alone in the management of colorectal cancer, retaining oxaliplatin in the treatment regimen is desirable, but the safety of combining bolus 5-FU with oxaliplatin in patients with FP-induced vasospasm is not well established. We performed a retrospective review to explore the safety of substituting FLOX (bolus 5-FU, oxaliplatin, leucovorin) for FOLFOX (infusional 5-FU, oxaliplatin, leucovorin) and CAPOX (capecitabine, oxaliplatin) in patients who had FP-induced coronary vasospasm. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.006DOI Listing
March 2019
2 Reads

Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients.

Clin Colorectal Cancer 2019 03 21;18(1):e20-e38. Epub 2018 Sep 21.

Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:

Introduction: The programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis plays an important role in controlling immune suppression by down-regulating T effector cell activities, enabling tumor cells to escape from the host's antitumor immunsurveillance. While only a small part of colon cancer cells express PD-L1, we sought to evaluate the differential impact of stromal and epithelial PD-L1 expression of primary tumors and liver metastasis on overall survival (OS) in colon cancer patients.

Patients And Methods: Using a next-generation tissue microarray approach, we assessed both epithelial and stromal PD-L1 expression levels in primary tumors (n = 279) and corresponding liver metastases (n = 14) of colon cancer patients. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.007DOI Listing
March 2019
19 Reads

Measurement of the IgM and IgG Autoantibody Immune Responses in Human Serum has High Predictive Value for the Presence of Colorectal Cancer.

Clin Colorectal Cancer 2019 03 27;18(1):e53-e60. Epub 2018 Sep 27.

Applied Biochemistry Group, School of Biotechnology, Dublin City University, Dublin, Ireland; Research Complex, Hamad Bin Khalifa University, Education City, Doha, Qatar. Electronic address:

Introduction: Colorectal cancer is a major public health issue, with incidences continuing to rise owing to the growing and aging world population. Current screening strategies for colorectal cancer diagnosis suffer from various limitations, including invasiveness and poor uptake. Consequently, there is an unmet clinical need for a minimally invasive, sensitive, and specific method for detecting the presence of colorectal cancer and pre-malignant lesions. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.009DOI Listing
March 2019
14 Reads

Fluoropyrimidine Cardiotoxicity: Time for a Contemporaneous Appraisal.

Clin Colorectal Cancer 2019 03 20;18(1):44-51. Epub 2018 Aug 20.

Division Hematology/Oncology Case, Department of Medicine, MetroHealth Cancer Center, Western Reserve University, Cleveland, OH.

Introduction: Fluoropyrimidines (FPDs) are a fundamental component of many chemotherapy regimens. Cardiotoxic adverse events (AEs) such as angina, ischemia, arrhythmias, and cardiomyopathy associated with 5-fluorouracil (5-FU) and capecitabine (CAPE) have been sparingly described in studies, primarily through case reports. Data from the 1990s revealed an estimated incidence of 0. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.08.001DOI Listing
March 2019
9 Reads

Prognostic Value of Baseline ALBI Score Among Patients With Colorectal Liver Metastases: A Pooled Analysis of Two Randomized Trials.

Clin Colorectal Cancer 2019 03 27;18(1):e61-e68. Epub 2018 Sep 27.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada. Electronic address:

Background: Baseline albumin-bilirubin (ALBI) score has been shown to be a reliable prognostic predictor among patients with hepatocellular carcinoma. The current study aims at evaluating its prognostic impact among patients with colorectal liver metastases treated with first-line systemic therapy.

Materials And Methods: Through the Project Data Sphere portal, de-identified clinical trial datasets of 2 clinical trials (NCT00115765; PACCE [Panitumumab Advanced Colorectal Cancer Evaluation Study] trial) and (NCT00364013; PRIME [Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy] trial) were downloaded. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.008DOI Listing
March 2019
7 Reads
2.910 Impact Factor

FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer.

Clin Colorectal Cancer 2019 03 21;18(1):e39-e52. Epub 2018 Sep 21.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Background: Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and efficacy of a modified schedule, FOLFCIS (leucovorin, fluorouracil, and cisplatin), and performed an integrated clinical and genomic analysis of anal SCC.

Patients And Methods: We reviewed all patients with advanced anal SCC receiving first-line FOLFCIS chemotherapy - essentially a FOLFOX (leucovorin, fluorouracil, and oxaliplatin) schedule with cisplatin substituted for oxaliplatin - in our institution between 2007 and 2017, and performed deep sequencing to identify genomic markers of response and key genomic drivers. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428631PMC
March 2019
2 Reads

ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.

Clin Colorectal Cancer 2018 12 13;17(4):255-257. Epub 2018 Sep 13.

Department of Medicine, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.clcc.2018.09.001DOI Listing
December 2018
2 Reads

ACTH-Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature.

Clin Colorectal Cancer 2019 03 11;18(1):e163-e170. Epub 2018 Aug 11.

Division of Medical Oncology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background: Approximately 30% of neuroendocrine tumors (NETs) present with secretory syndromes or develop one during the course of the disease. Cushing syndrome caused by a gastrointestinal tract NET is rare, with limited published information. We describe a patient with florid Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) from a NET of colonic origin. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.07.013DOI Listing
March 2019
5 Reads

Association Between Primary Payer Status and Survival in Patients With Stage III Colon Cancer: An National Cancer Database Analysis.

Clin Colorectal Cancer 2019 03 13;18(1):e1-e7. Epub 2018 Sep 13.

Creighton University School of Medicine, Omaha, NE.

Background: Colon cancer is the third most frequent cancer diagnosis, and primary payer status has been shown to be associated with treatment modalities and survival in cancer patients. The goal of our study was to determine the between-insurance differences in survival in patients with clinical stage III colon cancer using data from the National Cancer Database (NCDB).

Materials And Methods: We identified 130,998 patients with clinical stage III colon cancer in the NCDB diagnosed from 2004 to 2012. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.004DOI Listing
March 2019
2 Reads

Factors Affecting Oncologic Outcomes of 90Y Radioembolization of Heavily Pre-Treated Patients With Colon Cancer Liver Metastases.

Clin Colorectal Cancer 2019 03 13;18(1):8-18. Epub 2018 Sep 13.

Department of Interventional Oncology/Radiology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Introduction: The purpose of this study was to identify predictors of overall (OS) and liver progression-free survival (LPFS) following Yttrium-90 radioembolization (RAE) of heavily pretreated patients with colorectal cancer liver metastases (CLM), as well as to create and validate a predictive nomogram for OS.

Materials And Methods: Metabolic, anatomic, laboratory, pathologic, genetic, primary disease, and procedure-related factors, as well as pre- and post-RAE therapies in 103 patients with CLM treated with RAE from September 15, 2009 to March 21, 2017 were analyzed. LPFS was defined by Response Evaluation Criteria In Solid Tumors 1. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.08.004DOI Listing
March 2019
6 Reads

Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early-stage Colorectal Cancer.

Clin Colorectal Cancer 2019 03 13;18(1):19-27. Epub 2018 Sep 13.

Discipline of Radiology and Oncology, Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil; Department of Oncology, AC Camargo Cancer Center, São Paulo, Brazil. Electronic address:

Purpose: Chemotherapy-related cognitive impairment can occur in cancer survivors after treatment, especially those patients who have undergone chemotherapy for breast cancer. The frequency and to what extent such toxicity develops in colorectal cancer (CRC) survivors is unknown. The present prospective study evaluated the effects of adjuvant chemotherapy on the cognitive performance of patients with localized CRC compared with a control group who had not undergone chemotherapy. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.09.002DOI Listing
March 2019
5 Reads

Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy.

Clin Colorectal Cancer 2019 03 13;18(1):e8-e19. Epub 2018 Sep 13.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Background: Adenosine has an immunosuppressive and angiogenic modulation of the tumor microenvironment. The present study explored the efficacy of single nucleotide polymorphisms (SNPs) in adenosine-related molecules for patients with metastatic colorectal cancer treated with bevacizumab-based chemotherapy.

Patients And Methods: We analyzed genomic DNA extracted from 451 samples from 3 independent cohorts: a discovery cohort of 107 patients treated with FOLFIRI (5-fluorouracil, leucovorin, oxaliplatin, irinotecan) plus bevacizumab in FIRE-3 (ClinicalTrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183038
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http://dx.doi.org/10.1016/j.clcc.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416082PMC
March 2019
2 Reads

Short-Course Radiotherapy in Neoadjuvant Treatment for Rectal Cancer: A Systematic Review and Meta-analysis.

Clin Colorectal Cancer 2018 12 11;17(4):320-330.e5. Epub 2018 Aug 11.

Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: To assess whether preoperative short-course radiotherapy (PSRT) could be the treatment of choice compared to preoperative long-course chemoradiotherapy (PLCRT) METHODS: The PubMed, Embase, and Web of Science Databases were searched to conduct a systematic review and meta-analysis. Perioperative and survival outcomes between PSRT and PLCRT were selected as end points for our meta-analysis. In addition, health-related quality-of-life outcomes were also systematically reviewed between PSRT and PLCRT. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.07.014DOI Listing
December 2018
5 Reads
2.910 Impact Factor

Perioperative Management for Colorectal Peritoneal Metastases.

Clin Colorectal Cancer 2018 12 30;17(4):249-250. Epub 2018 Aug 30.

Department of Surgical Oncology, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Lyon, France; EMR 37-38, Lyon 1 University, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.08.005DOI Listing
December 2018
1 Read

Cost-effectiveness Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer in the United States.

Clin Colorectal Cancer 2018 12 24;17(4):e751-e761. Epub 2018 Aug 24.

Keck School of Medicine, University of Southern California, Los Angeles, CA.

Background: Regorafenib and TAS-102 are standard treatment options in refractory metastatic colorectal cancer based on improvement in overall survival by 6 and 8 weeks, respectively, when compared with best supportive care alone (BSC). Given the small incremental clinical benefit, we evaluated their cost-effectiveness from a United States payer's perspective.

Materials And Methods: A Markov model was constructed to compare costs and effectiveness of regorafenib, TAS-102, and BSC. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.08.003DOI Listing
December 2018
2 Reads

Immune-related Genes to Dominate Neutrophil-lymphocyte Ratio (NLR) Associated With Survival of Cetuximab Treatment in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2018 12 23;17(4):e741-e749. Epub 2018 Aug 23.

Division of Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.

Background: Few clinical studies have investigated the association between neutrophil-lymphocyte ratio (NLR) and treatment with cetuximab-based chemotherapy in metastatic colorectal cancer (mCRC). The NLR may reflect immune cells modulating specific cytokine signals in the tumor microenvironment; however, which immune-related genes affect the NLR remain unclear.

Patients And Methods: In 77 patients with KRAS exon2 wild-type mCRC from prospective trials of first-line chemotherapy with cetuximab, expression levels of 354 immune-related genes were measured in tissue samples obtained from all patients by the HTG EdgeSeq Oncology Biomarker Panel. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249067PMC
December 2018
5 Reads