4,412,278 results match your criteria Clinical Chiropractic [Journal]


The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678752
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http://dx.doi.org/10.1055/s-0039-1678752DOI Listing
November 2018
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Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Optimal Muscle Selection for OnabotulinumtoxinA Injections in Poststroke Lower-Limb Spasticity: A Randomized Trial.

Am J Phys Med Rehabil 2019 May;98(5):360-368

From the MossRehab Gait and Motion Analysis Laboratory, Elkins Park, Pennsylvania (AE); McGill University, Division of Neurology, Montreal General Hospital, Montreal, Quebec, Canada (THW); Staffordshire University, Faculty of Health and North Staffordshire Rehabilitation Centre, Haywood Hospital, Stoke-on-Trent, United Kingdom (ABW); Halifax Health, Brooks Rehabilitation, Daytona Beach, Florida (CG); Allergan plc, Bridgewater, New Jersey (CL); and Allergan plc, Irvine, California (RD).

Objective: The aim of the study was to identify optimal muscle selection patterns for onabotulinumtoxinA treatment of poststroke lower-limb spasticity.

Design: Adults with poststroke lower-limb spasticity (ankle Modified Ashworth Scale ≥3) were randomized to onabotulinumtoxinA (300 U, mandatory ankle plantar flexors; ≤100 U, optional lower-limb muscles) or placebo. Post hoc analysis assessed the impact of muscle selection patterns on ankle Modified Ashworth Scale and physician-assessed Clinical Global Impression of Change based on change from baseline to average of weeks 4/6 versus placebo. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001101DOI Listing
May 2019
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Variation in hospital charges in patients with external ventricular drains: comparison between the intensive care and surgical floor settings.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

3Department of Neurosurgery, University of Washington School of Medicine, Seattle, Washington.

OBJECTIVEPlacement of an external ventricular drain (EVD) is a common and potentially life-saving neurosurgical procedure, but the economic aspect of EVD management and the relationship to medical expenditure remain poorly studied. Similarly, interinstitutional practice patterns vary significantly. Whereas some institutions require that patients with EVDs be monitored strictly within the intensive care unit (ICU), other institutions opt primarily for management of EVDs on the surgical floor. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18545DOI Listing
April 2019
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Intracranial volume versus static and pulsatile intracranial pressure values in children with craniosynostosis.

J Neurosurg Pediatr 2019 Apr 19:1-9. Epub 2019 Apr 19.

1Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway; and.

OBJECTIVEReduced intracranial volume (ICV) and raised intracranial pressure (ICP) are assumed to be principal pathophysiological mechanisms in childhood craniosynostosis. This study examined the association between ICV and ICP and whether ICV can be used to estimate the ICP.METHODSThe authors analyzed ICV and ICP measurements from children with craniosynostosis without concurrent hydrocephalus and from age-matched individuals without craniosynostosis who underwent diagnostic ICP measurement. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18767DOI Listing
April 2019
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Clinical outcome of V-Y flap with latissimus dorsi and gluteal advancement for treatment of large thoracolumbar myelomeningocele defects: a comparative study.

J Neurosurg Pediatr 2019 Apr 19:1-10. Epub 2019 Apr 19.

1Department of Neurosurgery.

OBJECTIVESurgical repair and closure of myelomeningocele (MMC) defects are important and vital, as the mortality rate is as high as 65%-70% in untreated patients. Closure of large MMC defects is challenging for pediatric neurosurgeons and plastic surgeons. The aim of the current study is to report the operative characteristics and outcome of a series of Iranian patients with large MMC defects utilizing the V-Y flap and with latissimus dorsi or gluteal muscle advancement. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18232DOI Listing

Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

1Surgical Outcomes Center for Kids, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville.

OBJECTIVEAt failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV/CPC failure. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18743DOI Listing
April 2019
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Adjacent-segment disease following two-level axial lumbar interbody fusion.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

3Department of Orthopaedic Surgery, University of Tennessee College of Medicine, Chattanooga, Tennessee.

OBJECTIVEWhile long-term studies have evaluated adjacent-segment disease (ASD) following posterior lumbar spine arthrodesis, no such studies have assessed the incidence and prevalence of ASD following axial lumbar interbody fusion (AxiaLIF). The aim of this study was to estimate the incidence of ASD following AxiaLIF.METHODSThe authors retrospectively reviewed the medical records of 149 patients who underwent two-level index AxiaLIF and had at least 2 years of radiographic and clinical follow-up. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2019.2.SPINE18929DOI Listing
April 2019
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The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Neurosurgery, Oslo University Hospital; and.

OBJECTIVEAlthough many patients recover to a good functional outcome after aneurysmal subarachnoid hemorrhage (aSAH), residual symptoms are very common and may have a large impact on the patient's daily life. The particular cluster of residual symptoms after aSAH has not previously been described in detail and there is no validated questionnaire that covers the typical problems reported after aSAH. Many of the symptoms are similar to post-concussion syndrome, which often is evaluated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Read More

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http://dx.doi.org/10.3171/2019.1.JNS183168DOI Listing

Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease.

Adv Med Sci 2019 Apr 16;64(2):324-330. Epub 2019 Apr 16.

Department of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine (UCMMiT), Medical University of Gdansk, Gdynia, Poland; Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Gdynia, Poland.

Purpose: Hepatic alveolar echinococcosis (AE) is a parasitic disease caused by the larval stage of the tapeworm Echinococcus multilocularis. Ultrasonography is the method of choice in the initial diagnosis of AE. The aim of the study is to present the most frequent sonomorphological patterns of lesions in hepatic AE based on the analysis of ultrasound findings in patients treated for AE at the University Centre of Maritime and Tropical Medicine (UCMMiT; Gdynia, Poland), and to establish whether there is a relationship between the clinical stage of AE and the occurrence of a specific sonomorphological pattern of hepatic lesions. Read More

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http://dx.doi.org/10.1016/j.advms.2019.04.002DOI Listing

Worsening of disability caused by relapses in multiple sclerosis: A different approach.

Mult Scler Relat Disord 2019 Apr 15;32:1-8. Epub 2019 Apr 15.

The Danish Multiple Sclerosis Registry, Department of Neurology, Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Danish Multiple Sclerosis Center Rigshospitalet, University of Copenhagen, Denmark.

Background: In multiple sclerosis (MS) the quantitative role of relapses in Expanded Disability Status Scale (EDSS) worsening beyond the recovery phase is not well known. Most studies have examined the predictive role of early relapses in more distant endpoints. Relapses and worsening may be associated because they could be independent effects of the same underlying disease characteristics without causal relationship. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.017DOI Listing

Physiological validation of the decomposition of surface EMG signals.

Authors:
Roger M Enoka

J Electromyogr Kinesiol 2019 Mar 21;46:70-83. Epub 2019 Mar 21.

Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. Electronic address:

Advances in technology have ushered in a new era in the measurement and interpretation of surface-recorded electromyographic (EMG) signals. These developments have included improvements in detection systems, the algorithms used to decompose the interference signals, and the strategies used to edit the identified waveforms. To evaluate the validity of the results obtained with this new technology, the purpose of this review was to compare the results achieved by decomposing surface-recorded EMG signals into the discharge times of single motor units with what is known about the rate coding characteristics of single motor units based on recordings obtained with intramuscular electrodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10506411183038
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http://dx.doi.org/10.1016/j.jelekin.2019.03.010DOI Listing
March 2019
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Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease.

Cytokine 2019 Apr 16;120:54-61. Epub 2019 Apr 16.

IBD Centre, Toho University Sakura Medical Centre, Chiba, Japan. Electronic address:

Objective: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.014DOI Listing

Augmented and virtual reality in dental medicine: A systematic review.

Comput Biol Med 2019 Mar 15;108:93-100. Epub 2019 Mar 15.

Department of Reconstructive Dentistry, University Center for Dental Medicine Basel, University of Basel, Switzerland, Hebelstr. 3, CH-4056, Basel, Switzerland.

Background: The aim of this systematic review was to provide an update on the contemporary knowledge and scientific development of augmented reality (AR) and virtual reality (VR) in dental medicine, and to identify future research needs to accomplish its clinical translation.

Method: A modified PICO-strategy was performed using an electronic (MEDLINE, EMBASE, CENTRAL) plus manual search up to 12/2018 exploring AR/VR in dentistry in the last 5 years. Inclusion criteria were limited to human studies focusing on the clinical application of AR/VR and associated field of interest in dental medicine. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.012DOI Listing

Directional fast-marching and multi-model strategy to extract coronary artery centerlines.

Comput Biol Med 2019 Apr 5;108:67-77. Epub 2019 Apr 5.

School of Data Science, Fudan University, Shanghai, China. Electronic address:

Background: Computed tomography angiography (CTA) is a non-invasive technique to image coronary arteries and evaluate coronary artery diseases (CAD). The diagnosis of CAD requires modeling anatomical structures and analyzing the function and pathology of the coronary arteries. Therefore, a robust and automated method for extracting reliable coronary artery centerlines is valuable in clinical practice. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.029DOI Listing

Video-oculography eye tracking towards clinical applications: A review.

Comput Biol Med 2019 Mar 30;108:57-66. Epub 2019 Mar 30.

Research Institute for Signals, Systems and Computational Intelligence, Sinc(i), FICH-UNL/CONICET, Ruta Nac. No 168, Km 472.4 (3000), Santa Fe, Argentina.

Most neurological diseases are usually accompanied by a broad spectrum of oculomotor alterations. Being able to record and analyze these different types of eye movements would be a valuable tool to understand the functional integrity of brain structures. Nowadays, video-oculography is the most widely used eye-movements assessing method. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.025DOI Listing

Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner.

Comput Biol Med 2019 Mar 14;108:111-121. Epub 2019 Mar 14.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia; School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Australia.

Although intravascular ultrasound (IVUS) is the commonest intravascular imaging modality, it still is inefficient for clinical use as it requires laborious manual analysis. This study demonstrates the feasibility of a near real-time fully automated technology for accurate identification, detection, and quantification of luminal borders in intravascular images. This technology uses a combination of the novel approaches of a self-tuning engine, dynamic and static masking systems, radar-wise scan, and contour correction cycle method. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.008DOI Listing

Evaluation of contingency management as a strategy to improve HCV linkage to care and treatment in persons attending needle and syringe programs: A pilot study.

Int J Drug Policy 2019 Apr 16;69:1-7. Epub 2019 Apr 16.

Division of General Internal Medicine, Montefiore Medical Center, United States. Electronic address:

Background: A greater proportion of HCV-infected people who inject drugs (PWID) need to be linked to care for HCV antiviral treatment. This study sets out to evaluate the efficacy of contingency management (CM) for improving HCV linkage to care, treatment initiation, adherence, and cure for PWID recruited from a needle and syringe program.

Methods: Between March 2015 and April 2016, 20 participants were enrolled into the CM arm, and then subsequently enrolled 20 participants in the enhanced standard of care (eSOC) arm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193006
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http://dx.doi.org/10.1016/j.drugpo.2019.02.009DOI Listing
April 2019
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Neuroprotective effect of Dictyopteris divaricata extract-capped gold nanoparticles against oxygen and glucose deprivation/reoxygenation.

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.066DOI Listing

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019

Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice.

Pharmacol Rep 2019 Feb 8;71(3):466-472. Epub 2019 Feb 8.

Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.

Background: β-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic system activity may modify epilepsy course, the aim of the present study was to examine the effect of salbutamol (SALB), one of the most commonly used β-adrenergic receptor agonist on the anticonvulsant potency of four classical antiepileptic drugs (AEDs): valproate (VPA), carbamazepine (CBZ), phenytoin (DPH) and phenobarbital (PB) in mice subjected to the maximal electroshock (MES)-induced seizures.

Methods: Seizures were caused by a current delivered through ear-clip electrodes. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.003DOI Listing
February 2019

Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats.

Pharmacol Rep 2019 Jan 30;71(3):443-448. Epub 2019 Jan 30.

Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia. Electronic address:

Background: Chronic cerebral hypoperfusion (CCH) can induce the accumulation of reactive oxygen species, which leads to oxidative damage, neuronal injury, and central cholinergic dysfunction in vulnerable regions of the brain, such as the hippocampus and cerebral cortex. These effects can lead to significant cognitive impairments in clinical populations of vascular dementia (VaD). The present studies aimed to investigate the role of the cholinergic system in memory functions and hippocampal long-term potentiation (LTP) impairments induced by CCH in rats. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.012DOI Listing
January 2019

The role of rapid onset fentanyl products in the management of breakthrough pain in cancer patients.

Pharmacol Rep 2019 Jan 31;71(3):438-442. Epub 2019 Jan 31.

Chair and Department of Palliative Medicine, Poznan University of Medical Sciences, Poznań, Poland. Electronic address:

Breakthrough pain is defined as transient aggravation of pain that arises, despite well controlled or stable baseline pain. It may be preceded by known factors or occur spontaneously. Its prevalence is high and it considerably affects patients' quality of life. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.010DOI Listing
January 2019

The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019

Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis.

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.007DOI Listing
January 2019
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The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial.

Pharmacol Rep 2019 Feb 10;71(3):393-398. Epub 2019 Feb 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To assess the therapeutic efficacy, safety and tolerability of Guluronic acid (G2013) in patients with ankylosing spondylitis (AS) patients.

Methods: This investigation was a 12-week randomized, placebo-controlled, phase I/II clinical trial involving 75 AS patients that were randomly divided into 3 groups: 25 as placebo, 25 Guluronic acid and 25 naproxen groups. Patients who had AS with active disease at baseline according to the modified New York criteria were considered for this trial. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.002DOI Listing
February 2019

Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases.

Pharmacol Rep 2019 Jan 11;71(3):385-392. Epub 2019 Jan 11.

Dept of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.

Background: Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.

Methods: Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recipient ABCB1 (n = 318) genotypes influence tacrolimus pharmacokinetics till one-month of transplantation.

Results: The donor CYP3A5*3/*3 genotype exhibited higher concentration/dose (C/D) ratio of tacrolimus in week 1 (mean difference: 65. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.006DOI Listing
January 2019

Nurse anesthetists' preferences for anesthesiologists' participation in patient care at a large teaching hospital.

J Clin Anesth 2019 Apr 16;57:131-138. Epub 2019 Apr 16.

Department of Anesthesia, University of Iowa, United States of America.

Study Objective: Certified registered nurse anesthetists (CRNAs) can evaluate anesthesiologists with whom they work clinically using a psychometrically reliable and valid scale. Use of such a scale to evaluate performance depends on knowing thresholds for minimum and ideal anesthesiologist performance.

Design: Cohort study. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.04.018DOI Listing

Cortisol suppression after memory reactivation impairs later memory performance.

Psychoneuroendocrinology 2019 Apr 9;106:226-232. Epub 2019 Apr 9.

Laboratory for Behavioral Neurology and Imaging of Condition, Department of Basic Neurosciences, University of Geneva, Switzerland; Center for the Interdisciplinary Study of Gerontology and Vulnerability (CIGEV), University of Geneva, Switzerland; Swiss National Center of Competences in Research LIVES - Overcoming vulnerabilities: life course perspective, Lausanne and Geneva, Switzerland. Electronic address:

Experiencing stressful or traumatic events can result in disabling clinical symptoms of maladaptive emotional memory retrieval, which are only partly addressed by the currently proposed treatments. Cortisol modulation has been shown to affect emotional memory retrieval and potentially reconsolidation, offering an opportunity for developing more efficient treatments for disorders with an emotional memory component. Here, we investigated if cortisol suppression after reactivation of emotional memories weakens later memory thereof. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183123
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.035DOI Listing
April 2019
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Habitual and acute exercise effects on salivary biomarkers in response to psychosocial stress.

Psychoneuroendocrinology 2019 Mar 25;106:216-225. Epub 2019 Mar 25.

Department of Sport Science, Albert-Ludwigs-University Freiburg, Schwarzwaldstraße 175, Freiburg 79117, Germany. Electronic address:

Objective: Previous research suggests beneficial effects of physical exercise on stress reactivity due to cross-stressor adaptions of physiological stress response systems. However, results remain inconclusive and it is unclear whether only regular engagement in exercise modulates these physiological adaptations or if acute bouts of exercise can elicit similar adaptations. Thus, the aim of the current study was to investigate and compare the effects of habitual and acute exercise on physiological stress responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183088
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.015DOI Listing
March 2019
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Examining reactivity patterns in burnout and other indicators of chronic stress.

Psychoneuroendocrinology 2019 Apr 4;106:195-205. Epub 2019 Apr 4.

Department of Psychology, TU Dresden, Germany.

Introduction: Burnout symptomatology is associated with various negative health consequences; however, the mechanisms underlying these associations remain unclear. One potential pathway involves alterations in the acute stress response. The aims of the present study were to examine burnout-associated alterations in stress-reactivity patterns, during a standardized social stressor compared to a control condition, as well as to examine whether effects associated with greater burnout symptomatology were distinct from other, conceptually overlapping indicators of chronic stress (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183115
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http://dx.doi.org/10.1016/j.psyneuen.2019.04.002DOI Listing
April 2019
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PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.

Chemosphere 2019 Apr 12;227:389-400. Epub 2019 Apr 12.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515, Guangzhou, China. Electronic address:

Polychlorinated biphenyls (PCBs), a kind of persistent organic pollutant, can induce hepatotoxicity in mammals. However, PCB-induced hepatotoxicity in offspring and the underlying mechanisms have been rarely studied. In the present study, Wistar rats were administered with corn oil or PCB52 (1 mg/kg body weight/day, by gavage) from gestational day 7 to postnatal day 21. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193072
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.077DOI Listing
April 2019
2 Reads

Abdominal vagal deafferentation alters affective behaviors in rats.

J Affect Disord 2019 Apr 7;252:404-412. Epub 2019 Apr 7.

Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland.

Background: There is growing evidence for a role of abnormal gut-brain signaling in disorders involving altered mood and affect, including depression. Studies using vagus nerve stimulation (VNS) suggest that the disruption of vagal afferent signaling may contribute to these abnormalities. To test this hypothesis, we used a rat model of subdiaphragmatic vagal deafferentation (SDA), the most complete and selective vagal deafferentation method existing to date, to study the consequences of complete disconnection of abdominal vagal afferents on affective behaviors. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.015DOI Listing

Prevalence and potential determinants of subthreshold and major depression in the general population of Qatar.

Authors:
Salma M Khaled

J Affect Disord 2019 Apr 9;252:382-393. Epub 2019 Apr 9.

Social and Economic Survey Research Institute, Qatar University, Doha, Qatar. Electronic address:

Background: There is a paucity of epidemiological studies of depression in war-free Arab countries. This study estimated the prevalence and potential determinants of Subthreshold (SUBDE) and Major Depressive Episode (MDE) in migrants and non-migrants typical of Qatar and neighboring Gulf countries.

Methods: A telephone survey of a probability-based sample of 2,424 participants was conducted in February 2017. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.056DOI Listing

Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy.

Atherosclerosis 2019 Apr 8;285:40-48. Epub 2019 Apr 8.

Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy. Electronic address:

Background And Aims: Target and intensity of low-density lipoprotein cholesterol (LDL-C) lowering therapy should be tailored according to the individual global cardiovascular (CV) risk. We aimed at retrospectively evaluating real-life LDL-C goal attainment and predictive factors for predefined LDL-C therapeutic goals both in primary and secondary prevention.

Methods: We collected data from a large cohort of outpatients aged 40-65 years, followed by general practitioners, cardiologists and diabetologists in Italy. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.017DOI Listing

Toxic, cytogenetic and antitumor evaluations of [6]-gingerol in non-clinical in vitro studies.

Biomed Pharmacother 2019 Apr 16;115:108873. Epub 2019 Apr 16.

Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil; Postgraduate Program in Pharmaceutical Sciences, Laboratory of Genetic Toxicology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil.

Gingerol - [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; [6]-G) - is a phenolic compound with several pharmacological properties. Herein, the aim of the study was to evaluate the toxicogenic effects of [6]-G on Artemia salina nauplii, Allium cepa, HL-60 cell line and Sarcoma 180 (S-180) ascitic fluid cells.For toxic and genotoxic analysis, it was used [6]-G concentrations of 5, 10, 20 and 40 μg mL-1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183570
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http://dx.doi.org/10.1016/j.biopha.2019.108873DOI Listing
April 2019
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Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine.

Curr Opin Immunol 2019 Apr 16;59:42-48. Epub 2019 Apr 16.

Departments of Pedatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States. Electronic address:

Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk populations. VZV-specific immune responses induced by RZV, including the generation of polyfunctional T cells, are driven by the synergistic actions of the components of the vaccine adjuvant system. Read More

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http://dx.doi.org/10.1016/j.coi.2019.02.009DOI Listing

Electroconvulsive therapy "corrects" the neural architecture of visuospatial memory: Implications for typical cognitive-affective functioning.

Neuroimage Clin 2019 Apr 5;23:101816. Epub 2019 Apr 5.

Rotman Research Institute, University of Toronto, Canada. Electronic address:

Although electroconvulsive therapy (ECT) is a widely used and effective treatment for refractory depression, the neural underpinnings of its therapeutic effects remain poorly understood. To address this issue, here, we focused on a core cognitive deficit associated with depression, which tends to be reliably ameliorated through ECT, specifically, the ability to learn visuospatial information. Thus, we pursued three goals. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101816DOI Listing
April 2019
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Heme prevents highly amyloidogenic human calcitonin (hCT) aggregation: A potential new strategy for the clinical reuse of hCT.

J Inorg Biochem 2019 Apr 1;196:110686. Epub 2019 Apr 1.

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of chemistry and chemical Engineering, Huazhong university of Science and Technology, Wuhan 430074, People's Republic of China. Electronic address:

Irreversible aggregation can extremely limit the bioavailability and therapeutic activity of peptide-based drugs. Thus, peptide fibrillation is an excellent challenge for biotechnological drug development. Human calcitonin (hCT) is such a peptide hormone known for its hypocalcaemic effect but has limited pharmaceutical potential due to a high tendency to aggregate. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.026DOI Listing

A comparison of potential psychiatric drug interactions from six drug interaction database programs.

Psychiatry Res 2019 Mar 25;275:366-372. Epub 2019 Mar 25.

ChronoRecord Association, Fullerton, CA, USA.

Harmful drug-drug interactions (DDI) frequently include psychiatric drugs. Drug interaction database programs are viewed as a primary tool to alert physicians of potential DDI, but may provide different results as there is no standard to define DDI. This study compared the category of potential DDI provided by 6 commercial drug interaction database programs (3 subscription, 3 open access) for 100 drug interaction pairs. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.041DOI Listing

Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0.

Psychiatry Res Neuroimaging 2019 Mar 19;287:70-74. Epub 2019 Mar 19.

National Institute of Mental Health, Topolová 748, Klecany 250 67, Czechia; Institute of Clinical and Experimental Medicine, Czechia.

Ratios between opposing volumes from brain magnetic resonance imaging (MRI) can provide additional information to volumes in Alzheimer's disease (AD). Brain three-dimensional MPRAGE MRI at 3T were segmented into 44 regions using FreeSurfer v6 in 75 participants. The region's size in absolute volumes and relative proportions to the whole brain volume were compared between 39 AD patients and 36 age-, education- and sex-matched normal controls (NC). Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.014DOI Listing

Radiosynthesis and pre-clinical evaluation of [Ga] labeled antimicrobial peptide fragment GF-17 as a potential infection imaging PET radiotracer.

Appl Radiat Isot 2019 Apr 10;149:9-21. Epub 2019 Apr 10.

Department of Nuclear Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

The antimicrobial peptide fragment GF-17 was synthesized in-house and conjugated with DOTA and measured molecular mass of DOTA-GF-17 conjugate was 2489 Da. The peptide conjugate was purified and labeled with [Ga]. The best radiolabeling efficiency (95. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.04.008DOI Listing

Red blood cell membrane cholesterol in type 2 diabetes mellitus.

Thromb Res 2019 Apr 7;178:91-98. Epub 2019 Apr 7.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

Type II diabetes mellitus (T2DM) affects an estimate of 450 million individuals. Hence, there remains an urgent need to explore the use of novel biomarkers with the aim of preventing and managing cardiovascular risk among these individuals. Hallmarks of this condition are lipid and glucose dyshomeostasis which are accompanied by a prothrombotic phenotype; these pose as eminent links between T2DM and cardiovascular disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193018
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http://dx.doi.org/10.1016/j.thromres.2019.04.005DOI Listing
April 2019
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Effects of directional sound processing and listener's motivation on EEG responses to continuous noisy speech: Do normal-hearing and aided hearing-impaired listeners differ?

Hear Res 2019 Apr 11;377:260-270. Epub 2019 Apr 11.

Institute of Clinical Research, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. Electronic address:

Objective: It has been suggested that the next major advancement in hearing aid (HA) technology needs to include cognitive feedback from the user to control HA functionality. In order to enable automatic brainwave-steered HA adjustments, attentional processes underlying speech-in-noise perception in aided hearing-impaired individuals need to be better understood. Here, we addressed the influence of two important factors for the listening performance of HA users - hearing aid processing and motivation - by analysing ongoing neural responses during long-term listening to continuous noisy speech. Read More

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http://dx.doi.org/10.1016/j.heares.2019.04.005DOI Listing

Early stage detection and screening of ovarian cancer: A research opportunity and significant challenge for biosensor technology.

Biosens Bioelectron 2019 Mar 20;135:71-81. Epub 2019 Mar 20.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6. Electronic address:

Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large scale screening of women at an age of clinically significance through assay of biomarkers for disease present in blood or serum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193024
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http://dx.doi.org/10.1016/j.bios.2019.03.041DOI Listing
March 2019
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Clinical vasospasm after an extended endoscopic assisted approach for recurrent pituitary adenoma. Illustrative case and systematic review of the literature.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università; degli Studi di Napoli "Federico II", Naples, Italy.

Introduction: Cerebral vasospasm causing delayed cerebral ischemia after transsphenoidal surgery is a rare but life-threatening complication. Reports in the literature regarding extended endonasal endoscopic assisted (EEEA) approaches are scarce. Considering the progressive use of this technique during the last years, a better understanding of potential adverse effects after this procedure is needed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.046DOI Listing

The significance of intraoperative magnetic resonance imaging in resection of skull base chordomas.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

International Neuroscience Institute Rudolf-Pichlmayr-Straße 4 D - 30625 Hannover Germany.

Background: Skull base chordoma could be a challenging surgical entity due to its invasive nature.

Objective: In this study, we are evaluating the role of intraoperative magnetic resonance imaging to optimize the resection of skull base chordomas METHODS: We performed a retrospective analysis of the operated patients with skull base chordomas in the setting of iMRI. The clinical records, operative notes, radiological images, tumor volumetry, location of the residual tumor, and surgical outcome have been evaluated. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.086DOI Listing

Effect of selective serotonin reuptake inhibitors on markers of bone loss.

Psychiatry Res 2019 Apr 3;276:39-44. Epub 2019 Apr 3.

Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Several preclinical and clinical studies show that selective serotonin reuptake inhibitors (SSRI's) are associated with bone loss and an increase in fracture risk, not many reports on their effect on bone turnover markers. This cross-sectional study evaluated the effect of SSRIs treatment on bone turnover markers in Indian population for the first time. Inclusion criteria were subjects of either sex and age 18-45 years undergoing treatment with an SSRI for at least 3 months, regardless of the indication. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.04.006DOI Listing

[Do we need to perform systematic supracervical hysterectomy during laparoscopic sacrocolpopexy?]

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Département de Gynécologie-Obstétrique, Université de Liège, Centre Hospitalier Régional de la Citadelle, Boulevard du 12(e) de Ligne, 1, 4000 Liège, Belgique.

Objective: To evaluate the place of subtotal hysterectomy during laparoscopic sacrocolpopexy.

Methods: This retrospective observational study includes patients undergoing laparoscopic sacrocolpopexy between November 2010 and March 2015 at the Centre Hospitalier Régional de la Citadelle, Liège, Belgium. Patient characteristics, medical and surgical history were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189193015
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http://dx.doi.org/10.1016/j.gofs.2019.04.007DOI Listing
April 2019
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Modulation of the somatotropic axis, adiponectin and cytokine secretion during highly pathogenic porcine reproductive and respiratory syndrome virus type 1 (HP-PRRSV-1) infection.

Res Vet Sci 2019 Apr 11;124:263-269. Epub 2019 Apr 11.

Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy.

Porcine reproductive and respiratory syndrome virus (PRRSV) is known to be clinically responsible for reproductive failure in sows and post-weaning respiratory disease in growing piglets. During the last years, highly pathogenic PRRSV isolates have been discovered. In Italy, a PRRSV-1 subtype 1 strain (namely PR40/2014) characterized by high pathogenicity was isolated and experimental infection was characterized in terms of virological/clinical features and immune modulation (Canelli et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183159
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http://dx.doi.org/10.1016/j.rvsc.2019.04.007DOI Listing
April 2019
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