6,083 results match your criteria Clinical Chemistry and Laboratory Medicine CCLM [Journal]


Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and effects of thyroid diseases.

Clin Chem Lab Med 2019 Feb 22. Epub 2019 Feb 22.

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital of Leipzig, Leipzig, Germany.

Background There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). Read More

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http://dx.doi.org/10.1515/cclm-2018-1186DOI Listing
February 2019

Certified reference material against PR3 ANCA IgG autoantibodies. From development to certification.

Clin Chem Lab Med 2019 Feb 21. Epub 2019 Feb 21.

European Commission, Joint Research Centre, Geel, Belgium.

Background The importance of the standardisation of immunoassays for autoantibodies has been widely discussed. The appropriate use of certified reference materials (CRM) could contribute to a more accurate diagnosis and follow-up of a series of diseases such as small vessel-associated vasculitis. This is a systemic autoimmune disorder during which two autoantibodies can be present, MPO ANCA IgG and PR3 ANCA IgG. Read More

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http://dx.doi.org/10.1515/cclm-2018-1095DOI Listing
February 2019

Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations.

Clin Chem Lab Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.

A growing body of evidence has been published about the usefulness of measuring calprotectin in faecal samples (FCAL) in inflammatory bowel disease (IBD) assessment, including diagnosis, monitoring of disease activity and relapse prediction. Several systematic reviews with meta-analyses compiling studies for each particular clinical setting have been carried out in recent years. Most of these were focused on the use of FCAL in IBD diagnosis and showed a relevant role for this marker in selecting patients with gastrointestinal symptoms who would not need a further examination by endoscopy. Read More

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http://dx.doi.org/10.1515/cclm-2018-1063DOI Listing
January 2019

Evaluation of procalcitonin immunoassay concordance near clinical decision points.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Background Procalcitonin (PCT) is a biomarker for systemic bacterial infections and may aid in decision making for antimicrobial stewardship. Numerous PCT assays are available on common clinical immunoassay platforms. However, questions remain about the harmonization of these assays and whether the same clinical decision points may be used with all methods. Read More

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http://dx.doi.org/10.1515/cclm-2018-1362DOI Listing
February 2019

Measurement of S100B protein: evaluation of a new prototype on a bioMérieux Vidas® 3 analyzer.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Biochemistry and Molecular Biology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France.

Background The addition of S100B protein to guidelines for the management of mild traumatic brain injury (mTBI) decreases the amount of unnecessary computed tomography (CT) scans with a significant decrease in radiation exposure and an increase in cost savings. Both DiaSorin and Roche Diagnostics have developed automated assays for S100B determination. Recently, bioMérieux developed a prototype immunoassay for serum S100B determination. Read More

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http://dx.doi.org/10.1515/cclm-2018-1217DOI Listing
February 2019

The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Institute of Cardiology, Jagiellonian University Medical College and John Paul II Hospital, Krakow, Poland.

Background Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients. Methods We assessed 75 venous thromboembolism patients aged 44. Read More

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http://dx.doi.org/10.1515/cclm-2018-1197DOI Listing
February 2019
1 Read

Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Institute for Clinical Chemistry, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany, Phone: +49 - 621 383 2222, Fax: +49 - 621 383 3819.

Background The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), the antibiotic susceptibility testing (AST) remains time-consuming. Here, we present a rapid susceptibility testing method for testing Gram-negative bacteria, exemplarily validated for Escherichia coli and Klebsiella spp. Read More

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http://dx.doi.org/10.1515/cclm-2018-1178DOI Listing
February 2019
2 Reads

Inherited bisalbuminemia with growth hormone deficiency.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Biochemistry Laboratory, Bechir Hamza Children's Hospital, Bab Saadoun Square, Tunis, Tunisia.

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http://dx.doi.org/10.1515/cclm-2018-1133DOI Listing
February 2019
1 Read

Accuracy assessment of consecutive test strip lots for whole blood INR point-of-care instruments: clarifying the role of frozen plasma pools.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Coagulation Reference Laboratory, Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Background In the Netherlands, each new lot of test strips for the CoaguChek XS is validated by a group of collaborating centers. The purpose of this study was to assess the accuracy of the international normalized ratio (INR) measured with consecutive test strip lots and the suitability of frozen plasma pools for accuracy evaluation. Methods Each year, a particular lot of CoaguChek XS test strips is used as reference lot. Read More

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http://dx.doi.org/10.1515/cclm-2018-1054DOI Listing
February 2019

Evaluating the diagnostic and prognostic value of serum long non-coding RNA CTC-497E21.4 in gastric cancer.

Clin Chem Lab Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No 20, Xisi Road, Nantong 226001, P.R. China.

Background Long non-coding RNAs (lncRNAs) have been reported to play a key role in gastric cancer (GC) tumorigenesis. However, the clinical application value of serum lncRNAs in GC has remained largely unknown. We investigated the role of a novel lncRNA named CTC-497E21. Read More

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http://dx.doi.org/10.1515/cclm-2018-0929DOI Listing
January 2019

Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence.

Clin Chem Lab Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Cellular Physiology, G. Papanicolaou Research Center of Oncology, "Saint Savvas" Cancer Hospital of Athens, Athens, Greece.

Background Kallikrein-related peptidases (KLKs) are a subgroup of serine proteases located on chromosome 19q13.3. Most KLKs have been extensively studied as potential biomarkers for several carcinomas and other diseases. Read More

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http://dx.doi.org/10.1515/cclm-2018-1010DOI Listing
February 2019
3 Reads

Estimated urinary osmolality based on combined urinalysis parameters: a critical evaluation.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Laboratory Medicine, University Hospital Ghent, Ghent, Belgium.

Background Urinary conductivity allows a coarse prediction of urinary osmolality in most cases but is insensitive to the osmolal contribution of uncharged particles and the presence of roentgen contrast media. Urinary osmolality can be estimated on the recently introduced Sysmex UF-5000 urine analyzer using conductivity. In this study, we evaluated the analytical performance of this research parameter. Read More

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http://dx.doi.org/10.1515/cclm-2018-1307DOI Listing
February 2019

Narrowed reference intervals for complete blood count in a multiethnic population.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Laboratory Medicine, University of California, San Francisco, CA 94110, USA.

Background Biological variation studies have shown that the complete blood count (CBC) has narrow within-individual variation and wide group variation, indicating that the use of reference intervals (RIs) is challenging. The aim of this study was to examine differences in CBC RIs according to race/ethnicity in a multiethnic population at a hospital in San Francisco in hopes of improving the medical utility of CBC testing. Methods Subject data were obtained by screening CBC results from the medical records of outpatients meeting certain criteria who visited Zuckerberg San Francisco General Hospital from April 2017 to January 2018. Read More

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http://dx.doi.org/10.1515/cclm-2018-1263DOI Listing
February 2019

Urine chloride self-measurement to monitor sodium chloride intake in patients with chronic kidney disease.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

CNR-IFC Research Unit of Reggio Calabria, c/o EUROLINE di Barillà Francesca, Via Vallone Petrara 55-57, 89124 Reggio Calabria, Italy.

Background Excessive sodium intake is a risk factor for hypertension, cardiovascular disease and the risk for kidney failure in chronic kidney disease (CKD) patients. Methods We tested the diagnostic performance and the feasibility of an inexpensive method based on urine chloride strips for self-monitoring sodium intake in a series of 72 CKD patients. Results Twenty-four hour urinary chloride as measured by the reactive strips and 24 h urinary sodium were interrelated (r=0. Read More

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http://dx.doi.org/10.1515/cclm-2018-1227DOI Listing
February 2019
1 Read

Human chorionic gonadotropin suspected heterophile interference investigations in immunoassays: a recommended approach.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA.

Background Heterophile antibody (HAb) interferences in immunoassays can cause falsely elevated hCG concentrations leading to incorrect diagnosis and treatments options. When results are not consistent with the clinical findings, hCG HAb interference investigation may be requested by the physician. A retrospective evaluation of the frequency of HAb interference was performed among cases of physician-requested investigations and the effectiveness of commercially available blocking reagents to detect HAb interference in two immunoassay systems was evaluated. Read More

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http://dx.doi.org/10.1515/cclm-2018-1142DOI Listing
February 2019

Monitoring the effectiveness of hypothermia in perinatal asphyxia infants by urinary S100B levels.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Alessandria, Italy.

Background Perinatal asphyxia is a major cause of mortality and morbidity in neonates: The aim of the present study was to investigate, by means of longitudinal assessment of urinary S100B, the effectiveness of hypothermia, in infants complicated by perinatal asphyxia and hypoxic-ischemic encephalopathy. Methods We performed a retrospective case-control study in 108 asphyxiated infants, admitted to nine tertiary departments for neonatal intensive care from January 2004 to July 2017, of whom 54 underwent hypothermia treatment and 54 did not. The concentrations of S100B protein in urine were measured using an immunoluminometric assay at first urination and 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120 h after birth. Read More

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http://dx.doi.org/10.1515/cclm-2018-1094DOI Listing
February 2019
2 Reads

Implementation of an automated method for direct quantification of urinary ammonium.

Clin Chem Lab Med 2019 Feb 11. Epub 2019 Feb 11.

Biochemistry Department, Laboratory of Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1515/cclm-2018-1250DOI Listing
February 2019

Increased prevalence of anti-DFS70 antibodies in young females: experience from a large international multi-center study on blood donors.

Clin Chem Lab Med 2019 Feb 11. Epub 2019 Feb 11.

Inova Diagnostics, INC, 9900 Old Grove Road, San Diego, CA 32131-1638, USA, Phone/Fax: +858 586 9900/858 586 9911.

Background Isolated antibodies to DFS70 have been described in healthy individuals and are rarely found in patients with antinuclear antibody-associated autoimmune rheumatic diseases (AARD). However, no data is available on geographic differences in the prevalence of anti-DFS70 antibodies. We aimed to study the prevalence of anti-DFS70 antibodies in blood donor samples from several countries representing various ethnical backgrounds and geographic regions in the world. Read More

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http://dx.doi.org/10.1515/cclm-2018-1233DOI Listing
February 2019

Value-based healthcare: the role of laboratory medicine.

Clin Chem Lab Med 2019 Feb 9. Epub 2019 Feb 9.

IRCCS Orthopedic Institute Galeazzi, Milan, Italy.

The global increase of health demands pushes administrators and policy makers to provide good quality health care at sustainable costs. Many approaches have been developed, among which value-based health care (VBHC) is one of the most promising: value is given by outcomes achieved per dollar spent. Best value is given by shared benefits between all the stakeholders involved in the process: patients, providers, suppliers, payers and citizens. Read More

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http://dx.doi.org/10.1515/cclm-2018-1245DOI Listing
February 2019

The end of Laboratory Medicine as we know it?

Clin Chem Lab Med 2019 Feb;57(3):305-307

Former President of the European Federation for Clinical Chemistry and Laboratory Medicine, Department Laboratory Medicine, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1515/cclm-2018-1264DOI Listing
February 2019

Patient views on understanding laboratory results.

Authors:
Patricia Wilkie

Clin Chem Lab Med 2019 Feb;57(3):371-374

National Association for Patient Participation, Woking, Surrey, UK.

This paper examines the implications for laboratory staff of the technological changes enabling patients to have easy and quick access to their laboratory test results often without speaking with a health care professional. The needs of patients to receive results in easily understandable forms are described. The importance of sharing the concept of uncertainty with patients is discussed and explored including the challenges that this can create for staff. Read More

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http://dx.doi.org/10.1515/cclm-2018-0868DOI Listing
February 2019

Reference values of a new serum folate assay traceable to the WHO International Standard.

Clin Chem Lab Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical Chemistry, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2018-1229DOI Listing
February 2019

Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use.

Clin Chem Lab Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester and Basingstoke, UK.

Background Procalcitonin (PCT)-guided antibiotic stewardship (ABS) has been shown to reduce antibiotics (ABxs), with lower side-effects and an improvement in clinical outcomes. The aim of this experts workshop was to derive a PCT algorithm ABS for easier implementation into clinical routine across different clinical settings. Methods Clinical evidence and practical experience with PCT-guided ABS was analyzed and discussed, with a focus on optimal PCT use in the clinical context and increased adherence to PCT protocols. Read More

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http://dx.doi.org/10.1515/cclm-2018-1181DOI Listing
February 2019
2 Reads

Serum protein electrophoresis and complement deficiencies: a veteran but very versatile test in clinical laboratories.

Clin Chem Lab Med 2019 Feb 5. Epub 2019 Feb 5.

Immunology Department, Hospital Universitari Vall d'Hebron (HUVH), Diagnostic Immunology, Vall d'Hebron Research Institute (VHIR), Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UAB), Barcelona, Spain.

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http://dx.doi.org/10.1515/cclm-2018-1121DOI Listing
February 2019
1 Read

Practical problems when incorporating rapidly changing microbial taxonomy into clinical practice.

Clin Chem Lab Med 2019 Feb 5. Epub 2019 Feb 5.

The Johns Hopkins University School of Medicine, Department of Pathology, Division of Microbiology, Baltimore, MD, USA.

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http://dx.doi.org/10.1515/cclm-2018-1068DOI Listing
February 2019

Standardization of measurement procedures for serum uric acid: 8-year experience from Category 1 EQA program results in China.

Clin Chem Lab Med 2019 Feb 5. Epub 2019 Feb 5.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing Engineering Research Center of Laboratory Medicine, No 1, Dahua Road, Dongcheng District, Beijing, P.R. China.

Background Serum uric acid is a critical clinical indicator, and results without equivalence among laboratories cause troubles for disease diagnosis and patient management. External quality assessment (EQA) is a common tool for enhancing harmonization/standardization, therefore, the National Center for Clinical Laboratories in China has initiated a category 1 EQA for serum uric acid measurement since 2010 for evaluating its process of standardization. Methods Commutable EQA samples with target values assigned by reference measurement procedures were sent to participant laboratories. Read More

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http://dx.doi.org/10.1515/cclm-2018-0274DOI Listing
February 2019
1 Read

Folate and vitamin B12 assays after recalibration to the WHO International Standard 03/178: making the interpretation as simple as possible, but not simpler.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Clinical Pathology Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.

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http://dx.doi.org/10.1515/cclm-2019-0050DOI Listing
February 2019

Sepsis biomarkers: past, present and future.

Authors:
Giuseppe Lippi

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Section of Clinical Biochemistry, University Hospital of Verona, Piazzale LA Scuro, 37134 Verona, Italy.

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http://dx.doi.org/10.1515/cclm-2018-1347DOI Listing
February 2019
1 Read

Preanalytical challenges - time for solutions.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Laboratory Diagnostics, Clinical Hospital "Sveti Duh", Zagreb, Croatia.

The European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE) was originally established in 2013, with the main aims of (i) promoting the importance of quality in the preanalytical phase of the testing process, (ii) establishing best practices and providing guidance for critical activities in the preanalytical phase, (iii) developing and disseminating European surveys for exploring practices concerning preanalytical issues, (iv) organizing meetings, workshops, webinars or specific training courses on preanalytical issues. As education is a core activity of the WG-PRE, a series of European conferences have been organized every second year across Europe. This collective article summarizes the leading concepts expressed during the lectures of the fifth EFLM Preanalytical Conference "Preanalytical Challenges - Time for solutions", held in Zagreb, 22-23 March, 2019. Read More

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http://dx.doi.org/10.1515/cclm-2018-1334DOI Listing
February 2019
5 Reads

Advantages and limitations of total laboratory automation: a personal overview.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Laboratory Medicine, San Bassiano Hospital, Bassano del Grappa, Italy.

Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by assembly lines. The opportunity to integrate multiple diagnostic specialties to one single track seems effective to improve efficiency, organization, standardization, quality and safety of laboratory testing, whilst also providing a significant return of investment on the long-term and enabling staff requalification. Read More

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http://dx.doi.org/10.1515/cclm-2018-1323DOI Listing
February 2019
2 Reads

The first report showing de novo partial 21q monosomy in an adult woman with occult primary ovarian insufficiency (POI).

Clin Chem Lab Med 2019 Feb 4. Epub 2019 Feb 4.

Center for Molecular Diagnosis of Genetic Diseases, Dongfang Hospital, Xiamen University Medical College, 156 Xi'erhuanbei Road, Fuzhou City, Fujian Province 350025, P.R. China, Phone/Fax: +8659183721105.

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http://dx.doi.org/10.1515/cclm-2018-1271DOI Listing
February 2019
1 Read

Analytical and diagnostic performance evaluation of five creatinine POCT devices in the identification of patients at risk for post-contrast acute kidney injury (PCAKI).

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Department of Laboratory Medicine, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium, Phone: +32 (0)53/72 42 91, Fax: +32 (0)53/72 45 88.

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http://dx.doi.org/10.1515/cclm-2018-1105DOI Listing
February 2019
1 Read

Prognostic role of GDF-15 across the spectrum of clinical risk in patients with NSTE-ACS.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background Growth differentiation factor (GDF)-15 has been shown to predict cardiovascular (CV) outcomes in acute coronary syndrome (ACS) using non-commercial assays. We evaluated the prognostic performance of GDF-15 measured with the first clinically available assay. Furthermore, we evaluated whether GDF-15 was associated with CV death or heart failure (HF) across the spectrum of risk in non-ST-segment elevation (NSTE)-ACS. Read More

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http://dx.doi.org/10.1515/cclm-2018-1081DOI Listing
February 2019
2 Reads

Lipid profile and genetic status in a familial hypercholesterolemia pediatric population: exploring the LDL/HDL ratio.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Naples, Italy.

Background Familial hypercholesterolemia (FH) is a genetic disorder caused by mutations in genes involved in low-density lipoprotein (LDL) uptake (LDLR, APOB and PCSK9). Genetic diagnosis is particularly useful in asymptomatic children allowing for the detection of definite FH patients. Furthermore, defining their genetic status may be of considerable importance as the compound heterozygous status is much more severe than the heterozygous one. Read More

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http://dx.doi.org/10.1515/cclm-2018-1037DOI Listing
February 2019
1 Read

Hb Hunan and Hb Hengyang: Two unexpected discoveries during HbA1c measurements.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China, Phone: +86-0755-83923333-2299.

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http://dx.doi.org/10.1515/cclm-2018-1029DOI Listing
February 2019
2 Reads
2.955 Impact Factor

Analytical performance of a CE-marked immunoassay to quantify phosphorylated neurofilament heavy chains.

Clin Chem Lab Med 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven (University of Leuven), Leuven, Belgium.

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http://dx.doi.org/10.1515/cclm-2018-1004DOI Listing
February 2019
3 Reads

Acute-phase dynamics and prognostic value of growth differentiation factor-15 in ST-elevation myocardial infarction.

Clin Chem Lab Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Medicine, CIBERCV, Autonomous University of Barcelona, Barcelona, Spain.

Background Growth differentiation factor 15 (GDF-15) in ST-elevation myocardial infarction (STEMI) is prognostic in first-generation radioimmunoassays. We examined GDF-15 temporal dynamics in STEMI and its predictive value using a first fully automated GDF-15 electrochemiluminescence assay. Methods In this prospective study, circulating GDF-15 concentration was measured at admission (0 h), 12 h and 24 h in 1026 consecutive STEMI patients treated between February 2011 and May 2016 with primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1515/cclm-2018-1189DOI Listing
February 2019
2.955 Impact Factor

Vancomycin immunoassay: does the Advia Centaur XPT underestimate the exposure of patients? A method comparison study.

Clin Chem Lab Med 2019 Feb 1. Epub 2019 Feb 1.

Laboratory of Biological Pharmacology, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Rennes University Hospital, Rennes, France.

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http://dx.doi.org/10.1515/cclm-2018-1073DOI Listing
February 2019

Methodological issues are important in cannabinoids determination in bronchoalveolar lavage.

Clin Chem Lab Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Diseases of the Thorax, G.B. Morgagni - L. Pierantoni Hospital, via C. Forlanini 34, 47100 Forlì, FC, Italy, Phone: +39 0543/735399.

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http://dx.doi.org/10.1515/cclm-2018-1255DOI Listing
January 2019

Therapeutic drug monitoring (TDM) of 5-fluorouracil (5-FU): new preanalytic aspects.

Clin Chem Lab Med 2019 Jan 30. Epub 2019 Jan 30.

Day Treatment Center (TTZ), Interdisciplinary Tumor Center Mannheim (ITM) & III Medical Clinic, Mannheim, Germany.

Background 5-Fluorouracil (5-FU) is frequently used for the treatment of gastrointestinal tumors. The pharmacological effect of 5-FU is influenced by genetic polymorphisms as well as differently dosed regimens. Currently, 5-FU is generally administered as a continuous infusion via an implanted port system using a body surface area (BSA)-based dose calculation. Read More

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http://dx.doi.org/10.1515/cclm-2018-1177DOI Listing
January 2019

Jillian Russyll (AKA Jill) Tate.

Clin Chem Lab Med 2018 Dec;57(2):147

University Hospital Jena, Institut of Medical Statistics, Informatics and Documentation, Jena, Germany.

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http://www.degruyter.com/view/j/cclm.2019.57.issue-2/cclm-20
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http://dx.doi.org/10.1515/cclm-2018-2394DOI Listing
December 2018
5 Reads

Commutable whole blood reference materials for hemoglobin A1c validated on multiple clinical analyzers.

Clin Chem Lab Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore, Singapore.

Background The measurement of hemoglobin A1c (HbA1c) is important for diagnosing diabetes mellitus as well as assessing glycemic control in diabetic patients. Commutable whole blood certified reference materials (CRMs) are needed in the measurement of HbA1c for method validation and/or as quality controls. Methods We developed three levels of hemolyzed whole blood CRMs for HbA1c. Read More

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http://dx.doi.org/10.1515/cclm-2018-0861DOI Listing
December 2018
2 Reads
2.955 Impact Factor

Can Grail find the trail to early cancer detection?

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1515/cclm-2018-1249DOI Listing
December 2018
1 Read

Vitamin B12 and folate levels in a healthy population: establishing reference intervals.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Clinical Laboratory, Biochemistry Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Barcelona, Spain.

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http://dx.doi.org/10.1515/cclm-2018-1080DOI Listing
December 2018
1 Read

Point-of-care haemostasis monitoring during liver transplantation is cost effective.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Biochemistry, Virgen del Rocío University Hospital, Seville, Spain.

Background Optimal haemostasis management in orthotropic liver transplant (OLT) could reduce blood loss and transfusion volume, improve patient outcomes and reduce cost. Methods We performed a study including 336 OLTs to evaluate the clinical and cost effectiveness of a new point-of-care (POC)-based haemostatic management approach in OLT patients. Results In terms of health benefit we found that the new approach showed a significant reduction in transfusion requirements (red blood cell transfusion units were reduced from 5. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
Publisher Site
http://dx.doi.org/10.1515/cclm-2018-0889DOI Listing
December 2018
11 Reads

Diagnostics 4.0: the medical laboratory in digital health.

Authors:
Michael Neumaier

Clin Chem Lab Med 2019 Feb;57(3):343-348

Institute for Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.

During recent years, the digital revolution has changed the face of societies including industrial production, economies and peoples' social lives. From these changes we may extrapolate the developments that digitization of health care will bring to medicine in general and laboratory medicine in particular. Disruptive technologies will fundamentally change the way laboratory tests are going to be ordered, carried out and interpreted in the future, and test results from various sources need to be curated to be of added value for the patient's condition. Read More

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http://dx.doi.org/10.1515/cclm-2018-1088DOI Listing
February 2019
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Bone alkaline phosphatase on the IDS-iSYS automated analyser; cross-reactivity with intestinal ALP.

Clin Chem Lab Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Clinical Chemistry and Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1515/cclm-2018-0991DOI Listing
December 2018
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