6,148 results match your criteria Clinical Chemistry and Laboratory Medicine CCLM [Journal]


Roche Troponin T hs-STAT meets all expert opinion analytical laboratory practice recommendations for the use of the differential diagnosis of acute coronary syndrome.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Clinical Laboratory, Catharina Hospital, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2019-0267DOI Listing

Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740 3° andar, 04023-062 São Paulo, Brazil.

Background International autoantibody standards, traditionally based on material obtained from plasmapheresis of single subjects, represent individual immune response and may not comprehend the heterogeneity of the general population. The anti-DFS70 autoantibody yields a characteristic dense fine speckled (DFS) nuclear pattern on indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and speaks against autoimmunity. We propose a novel strategy for developing autoantibody reference standards, based on stepwise pooling of serum samples from hundreds of individuals with anti-DFS70 antibodies. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2019-0087DOI Listing
April 2019
1 Read

Next-generation reference intervals for pediatric hematology.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

Background Interpreting hematology analytes in children is challenging due to the extensive changes in hematopoiesis that accompany physiological development and lead to pronounced sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, and limitations in current approaches to laboratory test result displays restrict their use when guiding clinical decisions. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-1236DOI Listing
April 2019
1 Read

Practice in financial support of third party organised conferences and courses at a national level for health care professionals in Europe.

Clin Chem Lab Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Background Ethical MedTech prescribes high standards for the participation of the in vitro diagnostics (IVD) industry in third-party organised educational events in terms of charitable donations, educational grants, scholarships and fellowships. We planned a survey to investigate the previous and current practice in terms of cooperation between professionals or professional societies and the IVD industry, as well as plans under the incorporation of the MedTech Europe Code. Methods Different questions, from general information to specific questions related to the practice and knowledge of the new Ethical MedTech Code, were included in two different surveys; for European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) National Societies' (NSs) representatives, and for their (NSs) individual members. Read More

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http://dx.doi.org/10.1515/cclm-2019-0181DOI Listing

A comparison of biotin interference in routine immunoassays on the Roche Cobas 8000, Beckman Coulter DXi and Siemens Advia Centaur XPT immunoassay platforms.

Clin Chem Lab Med 2019 Apr 16. Epub 2019 Apr 16.

Clinical Biochemistry Department, Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK.

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http://dx.doi.org/10.1515/cclm-2019-0078DOI Listing

Comparison of six commercial serum exosome isolation methods suitable for clinical laboratories. Effect in cytokine analysis.

Clin Chem Lab Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.

Background Exosomes are nanovesicles released by cells that can be detected in blood. Exosomes contain several molecules, such as cytokines that have potential utility as disease biomarkers. The aim of the present work is to compare six different commercial kits suitable for the clinical laboratory in relation to the efficiency and purity of exosome isolation, and their effect in subsequent cytokines analysis. Read More

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http://dx.doi.org/10.1515/cclm-2018-1297DOI Listing

The silk road to total quality in Laboratory Medicine.

Clin Chem Lab Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy.

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http://dx.doi.org/10.1515/cclm-2019-0331DOI Listing

Lower creatinine concentration values and lower inter-laboratory variation among Swedish hospital laboratories in 2014 compared to 1996: results from the Equalis external quality assessment program.

Clin Chem Lab Med 2019 Apr 15. Epub 2019 Apr 15.

External Quality Assessment for Clinical Laboratory Investigations (Equalis), Uppsala, Sweden.

Background Creatinine measurement for estimation of glomerular filtration rate (GFR) is a frequently used laboratory test. Differences in analytic creatinine methods have caused large inter-laboratory variation. International and national standardization efforts have been made in the last decade. Read More

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http://dx.doi.org/10.1515/cclm-2018-0670DOI Listing

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Clin Chem Lab Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background Brevican, neurocan, tenascin-C and tenascin-R are extracellular matrix proteins present in brain that show increased expression in experimental animal models of brain injury. However, little is known about the dynamics of these proteins in human body fluids, such as cerebrospinal fluid (CSF) and serum, after traumatic brain injury (TBI). The aims of this study were to investigate if matrix proteins in CSF and serum are associated with functional outcome following traumatic brain injury, if their concentrations change over time and to compare their levels between brain injured patients to controls. Read More

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http://dx.doi.org/10.1515/cclm-2019-0034DOI Listing

A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers.

Clin Chem Lab Med 2019 Apr 12. Epub 2019 Apr 12.

Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, P.R. China.

Background Diagnostic biomarkers for the detection of colorectal cancers (CRCs) are lacking. Recent studies have demonstrated that circulating long non-coding RNAs have the potential to serve as biomarkers for the detection of cancers. We analyzed the significance of lncRNAs 91H, PVT-1 and MEG3 in the detection of CRC. Read More

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http://dx.doi.org/10.1515/cclm-2019-0052DOI Listing

Epigenetics in cancer: a promising path to follow?

Clin Chem Lab Med 2019 Apr 11. Epub 2019 Apr 11.

Institute for Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine and University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.

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http://dx.doi.org/10.1515/cclm-2019-0010DOI Listing

Prognostic value of involved/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients.

Clin Chem Lab Med 2019 Apr 11. Epub 2019 Apr 11.

Laboratoire de Biochimie-Toxicologie, Hôpital Pontchaillou CHU Rennes, Rennes, France.

Background Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder with a high risk of progression to symptomatic multiple myeloma (MM). The serum free light chain (sFLC) ratio is a powerful prognostic factor for SMM: an sFLC ratio ≥8 has been reported to be associated with a high risk of progression to MM, and an sFLC ratio ≥100 has been described as a criterion for ultra-high-risk SMM, and has been integrated into the definition criteria for MM since 2014. However, all recommendations were based on sFLC measured using the first commercialized assay, Freelite™, while other assays are now available. Read More

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http://dx.doi.org/10.1515/cclm-2018-1369DOI Listing
April 2019
1 Read

Fasting serum bile acids concentration is associated with insulin resistance independently of diabetes status.

Clin Chem Lab Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.

Background Bile acids (BAs) have been demonstrated to exert a variety of metabolic effects and alterations in BAs have been reported in patients with obesity, insulin resistance (IR) and type 2 diabetes mellitus (T2DM). However, it is unclear which metabolic condition is the main contributor to alterations in BAs. In this study, we investigate the associations between different BA profiles with glycemia, obesity or IR status. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-0741DOI Listing
April 2019
3 Reads

Total laboratory automation has the potential to be the field of application of artificial intelligence: the cyber-physical system and "Automation 4.0".

Clin Chem Lab Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1515/cclm-2019-0226DOI Listing
April 2019
1 Read

THC and CBD concentrations in blood, oral fluid and urine following a single and repeated administration of "light cannabis".

Clin Chem Lab Med 2019 Apr 8. Epub 2019 Apr 8.

Lambert Center for the Study of Medicinal Cannabis and Hemp, Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.

Background "Light cannabis" is a product legally sold in Europe with Δ9-tetrahydrocannabinol (THC) concentration lower than 0.2% and variable cannabidiol (CBD) content. We studied THC and CBD excretion profiles in blood, oral fluid (OF) and urine after smoking one or four light cannabis cigarettes. Read More

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http://dx.doi.org/10.1515/cclm-2019-0119DOI Listing
April 2019
5 Reads

Shortcomings in the evaluation of biomarkers in ovarian cancer: a systematic review.

Clin Chem Lab Med 2019 Apr 8. Epub 2019 Apr 8.

Amsterdam University Medical Centers, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Background Shortcomings in study design have been hinted at as one of the possible causes of failures in the translation of discovered biomarkers into the care of ovarian cancer patients, but systematic assessments of biomarker studies are scarce. We aimed to document study design features of recently reported evaluations of biomarkers in ovarian cancer. Methods We performed a systematic search in PubMed (MEDLINE) for reports of studies evaluating the clinical performance of putative biomarkers in ovarian cancer. Read More

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http://dx.doi.org/10.1515/cclm-2019-0038DOI Listing
April 2019
1 Read

Individualized metabolomics: opportunities and challenges.

Authors:
Biswapriya Misra

Clin Chem Lab Med 2019 Apr 5. Epub 2019 Apr 5.

Center for Precision Medicine, Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, 27157 NC, USA.

The goal of advancing science in health care is to provide high quality treatment and therapeutic opportunities to patients in need. This is especially true in precision medicine, wherein the ultimate goal is to link disease phenotypes to targeted treatments and novel therapeutics at the scale of an individual. With the advent of -omics technologies, such as genomics, proteomics, microbiome, among others, the metabolome is of wider and immediate interest for its important role in metabolic regulation. Read More

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http://dx.doi.org/10.1515/cclm-2019-0130DOI Listing
April 2019
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Biomarker-assisted identification of sepsis-related acute liver impairment: a frequent and deadly condition in critically ill patients.

Clin Chem Lab Med 2019 Apr 5. Epub 2019 Apr 5.

CHIP & PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen and University of Copenhagen, Copenhagen, Denmark.

Background The prognostic impact of mild/moderate liver impairment among critically ill patients is not known. We aimed to determine whether acute liver impairment, as measured by several biomarkers, (i) is frequent, (ii) influences prognosis and (iii) to determine whether such an effect is specific for infected critically ill patients. Methods A biomarker and clinical cohort study based on a randomized controlled trial. Read More

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http://dx.doi.org/10.1515/cclm-2018-1350DOI Listing
April 2019
2 Reads

Automated measurement of the erythrocyte sedimentation rate: method validation and comparison.

Clin Chem Lab Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy.

Background Development of automated analyzers for erythrocyte sedimentation rate (ESR) has imposed the need for extensive validation prior to their implementation in routine practice, to ensure comparability with the reference Westergren method. The aim of our study was to perform the analytical validation of two automated ESR analyzers, the Ves-Matic Cube 200 and the TEST1. Methods Validation was performed according to the recent International Council for Standardization in Hematology recommendations and included determination of intrarun and inter-run precision, assessment of sample carryover, hemolysis interference, sensitivity to fibrinogen, method comparison with the gold standard Westergren method and stability test. Read More

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http://dx.doi.org/10.1515/cclm-2019-0204DOI Listing

Influence of hypertriglyceridemia, hyperbilirubinemia and hemolysis on thrombin generation in human plasma.

Clin Chem Lab Med 2019 Apr 2. Epub 2019 Apr 2.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Background Although accumulating evidence suggests that the hemostatic balance is impaired in patients with hypertriglyceridemia, hyperbilirubinemia or hemolytic anemias, little is known on the underlying biological mechanisms. This experimental study was aimed at exploring whether increasing values of triglycerides, bilirubin or cell-free hemoglobin promote thrombin generation in plasma. Methods Three different pools were prepared from three different sets of 20 normal routine plasma citrate samples. Read More

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http://dx.doi.org/10.1515/cclm-2019-0135DOI Listing
April 2019
4 Reads

Clinical application of a dried blood spot assay for sirolimus and everolimus in transplant patients.

Clin Chem Lab Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. Methods A total of 39 sirolimus and 44 everolimus paired fingerprick DBS and whole blood (WB) samples were obtained from 60 adult transplant patients for method comparison using Passing-Bablok regression. Read More

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http://dx.doi.org/10.1515/cclm-2019-0053DOI Listing
April 2019
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Validation according to European and American regulatory agencies guidelines of an LC-MS/MS method for the quantification of free and total ropivacaine in human plasma.

Clin Chem Lab Med 2019 04 2. Epub 2019 Apr 2.

Plateforme de spectrométrie de masse MasSpecLab, INSERM UMR 1173, UFR Simone Veil - Santé, Université Versailles Saint Quentin, Université Paris Saclay, Montigny le Bretonneux, France.

Background: Ropivacaine is a widely used local anaesthetic drug, highly bound to plasma proteins with a free plasma fraction of about 5%. Therefore, the monitoring of free drug concentration is most relevant to perform pharmacokinetic studies and to understand the drug pharmacokinetic/pharmacodynamic (PK/PD) relationship.

Methods: A high-sensitivity liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using reverse-phase LC and electrospray ionisation mass spectrometry with multiple reaction monitoring (MRM) is described for the quantitation of both free and total ropivacaine in human plasma. Read More

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http://dx.doi.org/10.1515/cclm-2018-1298DOI Listing
April 2019
1 Read

Benefits and harms of wellness initiatives.

Clin Chem Lab Med 2019 Mar 26. Epub 2019 Mar 26.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Wellness projects are large scale studies of healthy individuals through extensive laboratory and other testing. The "Hundred Person Wellness Study", was one of the first to report results and lessons from its approach and these lessons can be applied to other wellness projects which are being undertaken by major companies and other organizations. In the "Hundred Person Wellness Study", investigators from the Institute for Systems Biology (ISB) sequenced the genome, and analyzed the blood, saliva, urine and microbiome of 108 healthy participants every 3 months, for 9 months, to look for subtle changes signifying the transition to disease. Read More

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http://dx.doi.org/10.1515/cclm-2019-0122DOI Listing

Subcutaneous adipose tissue distribution and telomere length.

Clin Chem Lab Med 2019 Mar 26. Epub 2019 Mar 26.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Background Overweight and obese individuals have a reduced life expectancy due to cardiovascular disease (CVD), type 2 diabetes, stroke and cancer. Systemic inflammation and premature telomere shortening have been discussed as potential mechanisms linking these conditions. We investigated the relation of subcutaneous adipose tissue (SAT) distribution to leukocyte relative telomere length (RTL). Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-0801DOI Listing
March 2019
4 Reads

Commutability of reference and control materials: an essential factor for assuring the quality of measurements in Laboratory Medicine.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milano, Italy.

Traceability to a common reference ensures equivalence of results obtained by different assays. Traceability is achieved by an unbroken sequence of calibrations, using reference materials (RMs) that must be commutable. Using non-commutable RMs for calibration will introduce a bias in the calibrated method producing incorrect results for clinical samples (CS). Read More

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http://dx.doi.org/10.1515/cclm-2019-0154DOI Listing

Blood from heparin tubes is an acceptable alternative to assess hematocrit determination.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

CHU Lille, Laboratory of Endocrinology, Metabolism-Nutrition, Oncology, Lille, France.

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http://dx.doi.org/10.1515/cclm-2019-0112DOI Listing

Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Celiac Disease Center-Comer Children's Hospital, Chicago, IL, USA.

Background An automated multiplex platform using capillary blood can promote greater throughput and more comprehensive studies in celiac disease (CD). Diagnostic accuracy should be improved using likelihood ratios for the post-test probability of ruling-in disease. Methods The Ig_plex™ Celiac Disease Panel on the sqidlite™ automated platform measured IgA and IgG antibodies to tTG and DGP in n = 224 CD serum or plasma samples. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2019-0088DOI Listing
March 2019
9 Reads

Design and implementation of quality control plans that integrate moving average and internal quality control: incorporating the best of both worlds.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background New moving average quality control (MA QC) optimization methods have been developed and are available for laboratories. Having these methods will require a strategy to integrate MA QC and routine internal QC. Methods MA QC was considered only when the performance of the internal QC was limited. Read More

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http://dx.doi.org/10.1515/cclm-2019-0027DOI Listing

The association between activated protein C ratio and Factor V Leiden are gender-dependent.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Background The most common cause of activated protein C (aPC) resistance is a missense substitution (Arg506Gln), known as Factor V Leiden (FVL). Due to its low cost, many laboratories use the aPC ratio as a primary test with a unisex cut-off. However, the association between the aPC ratio and FVL including any relation to gender has been sparsely investigated. Read More

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http://dx.doi.org/10.1515/cclm-2018-1382DOI Listing
March 2019
1 Read

Erroneous thyroid and steroid hormones profile due to anti-streptavidin antibodies.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Département des laboratoires cliniques, Cliniques Universitaires St. Luc - Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1515/cclm-2018-1355DOI Listing

Reference values for 24,25-dihydroxyvitamin D and the 25-hydroxyvitamin D/24,25-dihydroxyvitamin D ratio.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, de Boelelaan 1117, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2018-1096DOI Listing
March 2019
1 Read

Diagnostic accuracy of glycated hemoglobin for gestational diabetes mellitus: a systematic review and meta-analysis.

Clin Chem Lab Med 2019 Mar 20. Epub 2019 Mar 20.

Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Background We conducted a systematic review and meta-analysis to establish the overall accuracy of glycated hemoglobin (HbA1c) in the diagnosis of gestational diabetes mellitus (GDM) diagnosis. Methods We searched MEDLINE, EMBASE, SCOPUS and ClinicalTrials.gov up to October 2018, using keywords related to GDM, HbA1c and diagnosis. Read More

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http://dx.doi.org/10.1515/cclm-2018-1191DOI Listing

Performance of a novel high sensitivity cardiac troponin I assay in asymptomatic hemodialysis patients - evidence for sex-specific differences.

Clin Chem Lab Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tuebingen, Tuebingen, Germany.

Background High sensitivity assays for the determination of cardiac troponin I (cTnI) are able to reliably measure cTnI far below the 99th percentile of healthy persons (hs-cTnI) and display sex-specific differences. There is uncertainty regarding the clinical utility of hs-cTnI in asymptomatic hemodialysis (HD) patients and if sex-specific differences also apply in this cohort. Methods In this multicenter study we measured hs-cTnI and sensitive cTnI (s-TnI) concentrations (both on Siemens Centaur) in 215 HD patients from a predialytic sample to determine the prevalence of elevated concentrations above the 99th percentile, the association with baseline characteristics, prognostic accuracy for death, and sex-specific differences. Read More

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http://dx.doi.org/10.1515/cclm-2018-1176DOI Listing
March 2019
2.955 Impact Factor

Evaluation of the possible interference of abiraterone therapy on testosterone immunoassay.

Clin Chem Lab Med 2019 Mar 15. Epub 2019 Mar 15.

Laboratory Medicine Department, Ospedale dell'Angelo, ULSS 3 Serenissima, Mestre (Venice), Italy.

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http://dx.doi.org/10.1515/cclm-2018-1288DOI Listing

Measuring the chronology of the translational process of molecular genetic discoveries.

Clin Chem Lab Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Molecular Biology, Medical Biology and Pathology, Faculty of Medicine, Université Laval, Quebec City, Canada.

Background The process of technology validation and transfer of new molecular diagnostic tests towards the clinic faces challenges and needs to be improved. There is no empirical measure of the chronology and pace of technology transfer of molecular genetic discoveries. Methods We studied these for 29 molecular genetic test discoveries in order to (1) provide estimates of the timeframe between discovery of a clinical application and complete clinical implementation, and (2) compare the trajectories between different new tests to identify common patterns. Read More

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http://dx.doi.org/10.1515/cclm-2018-1126DOI Listing

Cardiac biomarkers - 2019.

Authors:
Karl J Lackner

Clin Chem Lab Med 2019 Apr;57(5):565-566

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55101 Mainz, Germany, Phone: +49 6131 177190, Fax: +49 6131 176627.

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http://dx.doi.org/10.1515/cclm-2019-0205DOI Listing

The end of Laboratory Medicine as we know it?

Clin Chem Lab Med 2018 Dec 18. Epub 2018 Dec 18.

Former President of the European Federation for Clinical Chemistry and Laboratory Medicine, Department Laboratory Medicine, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1515/cclm-2018-1264DOI Listing
December 2018

Patient views on understanding laboratory results.

Authors:
Patricia Wilkie

Clin Chem Lab Med 2018 Dec 14. Epub 2018 Dec 14.

National Association for Patient Participation, Woking, Surrey, UK.

This paper examines the implications for laboratory staff of the technological changes enabling patients to have easy and quick access to their laboratory test results often without speaking with a health care professional. The needs of patients to receive results in easily understandable forms are described. The importance of sharing the concept of uncertainty with patients is discussed and explored including the challenges that this can create for staff. Read More

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http://dx.doi.org/10.1515/cclm-2018-0868DOI Listing
December 2018

Outlier removal methods for skewed data: impact on age-specific high-sensitive cardiac troponin T 99th percentiles.

Clin Chem Lab Med 2019 Mar 12. Epub 2019 Mar 12.

Department of Metabolic Biochemistry, La Pitié Salpêtrière-Charles Foix University Hospital (AP-HP), Paris, France.

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http://dx.doi.org/10.1515/cclm-2018-1366DOI Listing
March 2019
1 Read
2.955 Impact Factor

Elucidation of stability profiles of common chemistry analytes in serum stored at six graded temperatures.

Clin Chem Lab Med 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube 755-8505, Japan.

Background Many reports address the stability of biochemical analytes in serum. However, studies covering a wide range of storage temperatures are unavailable. Using equipment enabling precise temperature control, we investigated the effect of six different storage temperatures on serum analytes. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-1109DOI Listing
March 2019
2 Reads

Sample matrix and high-sensitivity cardiac troponin I assays.

Clin Chem Lab Med 2019 Apr;57(5):745-751

Mayo Clinic, Rochester, MN, USA.

Background Manufacturers of high-sensitivity cardiac troponin (hs-cTn) assays have restricted use of what sample types or matrices are acceptable to use for measurement. Our goal was to evaluate the comparability of the Siemens ADVIA Centaur hs-cTnI assay across different matrices and under different storage conditions. Methods Three different QC-plasma matrices were evaluated for imprecision <10 ng/L. Read More

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http://dx.doi.org/10.1515/cclm-2018-1100DOI Listing

A novel machine learning-derived decision tree including uPA/PAI-1 for breast cancer care.

Clin Chem Lab Med 2018 Dec 20. Epub 2018 Dec 20.

Unité de Sénologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 and to build a new therapeutic decision tree integrating uPA/PAI-1. Methods We observed the concordance between CT indications proposed by a canonical decision tree representative of French practices (not including uPA/PAI-1) and actual CT prescriptions decided by a medical board which included uPA/PAI-1. Read More

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http://dx.doi.org/10.1515/cclm-2018-1065DOI Listing
December 2018
1 Read

Improvement in detecting sepsis using leukocyte cell population data (CPD).

Clin Chem Lab Med 2018 Dec 20. Epub 2018 Dec 20.

Research Unit, REDISSEC, Health Services Research on Chronic Patients Network, Hospital Galdakao - Usansolo, Galdakao, Vizcaya, Spain.

Background The cell population data (CPD) parameters reported by XN analyzers (Sysmex Corporation, Kobe, Japan) reflect the size and internal structure of leukocytes. We explored whether CPD values could contribute to recognize those patients with fever at risk to develop sepsis. A profile of sepsis was developed combining CPD parameters and other markers. Read More

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http://dx.doi.org/10.1515/cclm-2018-0979DOI Listing
December 2018
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A pilot study for establishing quality indicators in molecular diagnostics according to the IFCC WG-LEPS initiative: preliminary findings in China.

Clin Chem Lab Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Laboratory, Beijing Chaoyang Hospital, The Third Clinical Medical College of Capital Medical University, Beijing, P.R. China.

Background Quality indicators (QIs) are crucial tools in measuring the quality of laboratory services. Based on the general QIs of the Working Group "Laboratory Errors and Patient Safety (WG-LEPS)" of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), specific QIs have been established in order to monitor and improve the quality of molecular diagnostics, and to assess the detection level of associated disease. Methods A survey was conducted on 46 independent commercial laboratories in China, investigated using questionnaires and on-site inspections. Read More

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http://dx.doi.org/10.1515/cclm-2018-0966DOI Listing
December 2018