23,975 results match your criteria Clinical Chemistry[Journal]


A Message to Medical School Promotion Committees: Proper Credit for Peer-Reviewed Online Educational Materials.

Clin Chem 2019 Apr 19. Epub 2019 Apr 19.

Department of Health Systems Science, Kaiser Permanente School of Medicine, Pasadena, CA.

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http://dx.doi.org/10.1373/clinchem.2019.305862DOI Listing

Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA.

Background: Untargeted data acquisition on high-resolution mass spectrometers (HRMSs) has been used in clinical toxicology for screening and identifying unknown compounds in patient samples. A common modality for untargeted HRMS data acquisition is information-dependent acquisition (IDA), which analyzes the most abundant small molecules within an acquisition cycle. This process can potentially lead to false negatives of clinically relevant compounds at low concentrations. Read More

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http://dx.doi.org/10.1373/clinchem.2018.300756DOI Listing

Hyperglycemia and Adverse Pregnancy Outcomes.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

Centre for Public Health, Queen's University of Belfast, Belfast, UK.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2019.303
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http://dx.doi.org/10.1373/clinchem.2019.303990DOI Listing
April 2019
1 Read

The Importance of Reliable Quality Control Materials for Noninvasive Prenatal Testing.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2019.303701DOI Listing

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity From Serum.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;

Background: HDL-mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have a protective role in atherogenesis. However, the estimation of HDL-CEC is based on in vitro cell assays that are laborious and hamper large-scale phenotyping.

Methods: Here, we present a cost-effective high-throughput nuclear magnetic resonance (NMR) spectroscopy method to estimate HDL-CEC directly from serum. Read More

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.299
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http://dx.doi.org/10.1373/clinchem.2018.299222DOI Listing
April 2019
2 Reads

Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China;

Background: Reliable noninvasive biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis are urgently needed. We explored the potential of not only microRNAs (miRNAs) but other types of noncoding RNAs (ncRNAs) as HCC biomarkers.

Methods: Peripheral blood samples were collected from 77 individuals; among them, 57 plasma cell-free RNA transcriptomes and 20 exosomal RNA transcriptomes were profiled. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301150DOI Listing

Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway;

Background: Cardiac troponins are associated with cardiovascular risk in the general population, but whether temporal changes in cardiac troponin I provide independent prognostic information remains uncertain. Using a large community-based cohort with follow-up to the present day, we aimed to investigate the associations between temporal changes in cardiac troponin and cardiovascular events.

Methods: We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attending both the second (HUNT 2, 1995-97) and third wave (HUNT 3, 2006-2008) of the prospective observational Nord-Trøndelag Health (HUNT) Study. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301069DOI Listing

Rapid One-Step Plasma Test for the Electrochemical and Colorimetric Detection of a Universal Cancer Biomarker.

Authors:
Jae-Seung Lee

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Department of Materials Science and Engineering, Korea University, Seoul, Republic of Korea.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.300
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http://dx.doi.org/10.1373/clinchem.2018.300723DOI Listing
April 2019
3 Reads

High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction.

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland;

Background: The aim of this study was to validate the clinical performance of the Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.

Methods: We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists with all clinical information including cardiac imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, using hs-cTnI (Architect, secondary analysis) measurements in addition to the clinically used hs-cTn. Read More

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http://dx.doi.org/10.1373/clinchem.2018.300061DOI Listing
April 2019
1 Read

What the Protecting Access to Medicare Act Means for Clinical Laboratories.

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Director, Corporate Reimbursement, Government Affairs, Abbott Laboratories, Abbott Park, IL.

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http://dx.doi.org/10.1373/clinchem.2019.303255DOI Listing

Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling.

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

Background: The current diagnosis and monitoring of bladder cancer are heavily reliant on cystoscopy, an invasive and costly procedure. Previous efforts in urine-based detection of bladder cancer focused on targeted approaches that are predicated on the tumor expressing specific aberrations. We aimed to noninvasively detect bladder cancer by the genome-wide assessment of methylomic and copy number aberrations (CNAs). Read More

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http://dx.doi.org/10.1373/clinchem.2018.301341DOI Listing

Cardiac and Inflammatory Biomarkers Are Associated with Worsening Renal Outcomes in Patients with Type 2 Diabetes Mellitus: Observations from SAVOR-TIMI 53.

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;

Background: Cardiac and renal diseases commonly occur with bidirectional interactions. We hypothesized that cardiac and inflammatory biomarkers may assist in identification of patients with type 2 diabetes mellitus (T2DM) at high risk of worsening renal function.

Methods: In this exploratory analysis from SAVOR-TIMI 53, concentrations of high-sensitivity cardiac troponin T (hs-TnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP) were measured in baseline serum samples of 12310 patients. Read More

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http://dx.doi.org/10.1373/clinchem.2018.298489DOI Listing
April 2019
1 Read

Forest.

Authors:
Nader Rifai

Clin Chem 2019 Apr;65(4):606

Boston Children's Hospital, Boston, MA.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.299
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http://dx.doi.org/10.1373/clinchem.2018.299735DOI Listing
April 2019
3 Reads

A Nose for Diagnosing Asthma.

Authors:
Vikram S Kumar

Clin Chem 2019 Apr;65(4):603-605

Dimagi Inc., Cambridge, MA.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2019.302
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http://dx.doi.org/10.1373/clinchem.2019.302232DOI Listing
April 2019
5 Reads

The Case of Missing Immunofixation Bands.

Clin Chem 2019 Apr;65(4):601-602

Department of Laboratory Medicine, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1373/clinchem.2018.296921DOI Listing

Sudden Onset Nephrotic-Range Proteinuria.

Clin Chem 2019 Apr;65(4):600-601

Service de Biochimie, Timone University Hospital, AP-HM, Marseille, France.

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http://dx.doi.org/10.1373/clinchem.2018.295519DOI Listing

A Potentially Volatile Situation.

Clin Chem 2019 Apr;65(4):598-599

Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1373/clinchem.2018.297978DOI Listing
April 2019
1 Read

Unusual Metabolites in a Patient with Isovaleric Acidemia.

Clin Chem 2019 Apr;65(4):595-597

Department of Pediatrics, University of Louisville, Louisville, KY.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.300
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http://dx.doi.org/10.1373/clinchem.2018.300558DOI Listing
April 2019
2 Reads

Commentary.

Authors:
Melanie P Hoenig

Clin Chem 2019 Apr;65(4):518

Medicine-Renal Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1373/clinchem.2018.299339DOI Listing

Commentary.

Clin Chem 2019 Apr;65(4):517-518

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.

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http://dx.doi.org/10.1373/clinchem.2018.290551DOI Listing

An Unusual Cause of Metabolic Alkalosis and Hypocalcemia in Childhood.

Clin Chem 2019 Apr;65(4):514-517

Department of Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1373/clinchem.2018.287136DOI Listing
April 2019
1 Read

Patrick Bossuyt.

Authors:
Misia Landau

Clin Chem 2019 Apr;65(4):503-506

e-mail

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http://dx.doi.org/10.1373/clinchem.2018.300681DOI Listing

Effect of Storage Temperature for B-Type Natriuretic Peptide Concentrations for Primary Healthcare Populations.

Clin Chem 2019 Mar 27. Epub 2019 Mar 27.

Department of Health Research Methods Evidence and Impact, McMaster University Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1373/clinchem.2018.300749DOI Listing

Iron Metabolism, Hepcidin, and Mortality (the Ludwigshafen Risk and Cardiovascular Health Study).

Clin Chem 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine III and IZKF, University Hospital Aaachen, Aachen, Germany.

Background: Anemia has been shown to be a risk factor for coronary artery disease (CAD) and mortality, whereas the role of iron metabolism remains controversial.

Methods: We analyzed iron metabolism and its associations with cardiovascular death and total mortality in patients undergoing coronary angiography with a median follow-up of 9.9 years. Read More

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.297
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http://dx.doi.org/10.1373/clinchem.2018.297242DOI Listing
March 2019
7 Reads

In Reply.

Clin Chem 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical BiochemistryCopenhagen University Hospital Hvidovre, Hvidovre, Denmark

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http://dx.doi.org/10.1373/clinchem.2019.302034DOI Listing

Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis.

Clin Chem 2019 Mar 26. Epub 2019 Mar 26.

Fudan University Shanghai Cancer Center, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China;

Background: Extracellular vesicles (EVs) contain a rich cargo of different RNA species with specialized functions and clinical applications. However, the landscape and characteristics of extracellular vesicle long RNA (exLR) in human blood remain largely unknown.

Methods: We presented an optimized strategy for exLR sequencing (exLR-seq) of human plasma. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301291DOI Listing
March 2019
2 Reads
7.911 Impact Factor

Albumin-Adjusted Calcium and Ionized Calcium.

Authors:
R Brian Payne

Clin Chem 2019 Mar 25. Epub 2019 Mar 25.

Department of Chemical Pathology St James's University Hospital Leeds, UK (Retired)

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.300
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http://dx.doi.org/10.1373/clinchem.2018.300905DOI Listing
March 2019
2 Reads

Misclassification of Calcium Status Based on Albumin-Adjusted Calcium: Studies in a Tertiary Hospital Setting-In Reply.

Clin Chem 2019 Mar 25. Epub 2019 Mar 25.

Clinical Biochemistry UnitAlfred Pathology ServiceAlfred HealthMelbourne, Victoria, Australia.

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http://dx.doi.org/10.1373/clinchem.2019.302216DOI Listing

Generation of Highly Biomimetic Quality Control Materials for Noninvasive Prenatal Testing Based on Enzymatic Digestion of Matched Mother-Child Cell Lines.

Clin Chem 2019 Mar 14. Epub 2019 Mar 14.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China;

Background: Noninvasive prenatal testing (NIPT) based on cell-free DNA (cfDNA) is widely used. However, biomimetic quality control materials that have properties identical to clinical samples and that are applicable to a wide range of methodologies are still not available to support assay development, internal quality control, and proficiency testing.

Methods: We developed a set of dual enzyme-digested NIPT quality control materials (DENQCMs) that comprise simulated human plasma and mixtures of mother cell line-derived cfDNA based on DNA fragmentation factor digestion (D-cfDNA) and the matched child cell line-derived cfDNA based on micrococcal nuclease digestion (M-cfDNA). Read More

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http://dx.doi.org/10.1373/clinchem.2018.299602DOI Listing
March 2019
3 Reads
7.911 Impact Factor

Single-Cell Genomics.

Clin Chem 2019 Mar 14. Epub 2019 Mar 14.

Department of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA;

Background: Single-cell genomics is an approach to investigate cell heterogeneity and to identify new molecular features correlated with clinical outcomes. This approach allows identification of the complexity of cell diversity in a sample without the loss of information that occurs when multicellular or bulk tissue samples are analyzed.

Content: The first single-cell RNA-sequencing study was published in 2009, and since then many more studies and single-cell sequencing methods have been published. Read More

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http://dx.doi.org/10.1373/clinchem.2017.283895DOI Listing

Effect of Smoked Cannabis on Vigilance and Accident Risk Using Simulated Driving in Occasional and Chronic Users and the Pharmacokinetic-Pharmacodynamic Relationship.

Clin Chem 2019 Mar 14. Epub 2019 Mar 14.

AP-HP, Hôpital Raymond Poincaré, Service de Pharmacologie Toxicologie, Garches, INSERM U-1173, Université de Versailles-St. Quentin, France;

Background: The pharmacokinetic-pharmacodynamic relationship between whole blood δ-9-tetrahydrocannabinol (THC) and driving risk is poorly understood.

Methods: Fifteen chronic cannabis consumers (1-2 joints/day; CC) and 15 occasional cannabis consumers (1-2 joints/week; OC) of 18 to 34 years of age were included. A pharmacokinetic study was conducted with 12 blood samplings over a 24-h period before and after controlled random inhalation of placebo or 10 mg or 30 mg of THC. Read More

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http://dx.doi.org/10.1373/clinchem.2018.299727DOI Listing
March 2019
2 Reads

High-Density Lipoproteins and Inflammatory Diseases: Full Circle Ahead.

Clin Chem 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1373/clinchem.2019.302364DOI Listing
March 2019
1 Read

Commutability of a Whole-Blood External Quality Assessment Material for Point-of-Care C-Reactive Protein, Glucose, and Hemoglobin Testing.

Clin Chem 2019 Mar 11. Epub 2019 Mar 11.

Norwegian Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway.

Background: The optimal situation in external quality assessment (EQA) is to use commutable materials. No previous study has examined the commutability of a whole-blood material for point-of-care (POC) testing. The aim of this study was to determine the commutability of the Norwegian Quality Improvement of Laboratory Examinations (Noklus) organization's "in-house" whole-blood EQA material for C-reactive protein (CRP), glucose, and hemoglobin for frequently used POC instruments in Norway and to determine the possibility of using a common target value for each analyte. Read More

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http://dx.doi.org/10.1373/clinchem.2018.300202DOI Listing
March 2019
2 Reads

Full-Size and Partially Truncated Cardiac Troponin Complexes in the Blood of Patients with Acute Myocardial Infarction.

Clin Chem 2019 Mar 11. Epub 2019 Mar 11.

HyTest Ltd., Turku, Finland.

Background: The measurement of cardiac isoforms of troponin I (cTnI) and troponin T (cTnT) is widely used for the diagnosis of acute myocardial infarction (AMI). However, there are conflicting data regarding what forms of cTnI and cTnT are present in the blood of AMI patients. We investigated cTnI and cTnT as components of troponin complexes in the blood of AMI patients. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301127DOI Listing

Rapid Genome Sequencing in the Critically lll.

Clin Chem 2019 Mar 6. Epub 2019 Mar 6.

Stanford Medicine Clinical Genomics Program, Stanford Health Care, Stanford, CA;

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http://dx.doi.org/10.1373/clinchem.2018.293506DOI Listing

A Woman and a Coffee Cup.

Clin Chem 2019 Mar;65(3):501

University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, UK.

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http://dx.doi.org/10.1373/clinchem.2018.299537DOI Listing
March 2019
2 Reads

The Curious Case of an Isolated Positive Hepatitis B Surface Antigen Result.

Clin Chem 2019 Mar;65(3):499-500

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH;

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http://dx.doi.org/10.1373/clinchem.2018.294157DOI Listing

Is This as Straightforward as It Looks?

Clin Chem 2019 Mar;65(3):498-499

Department of Pathology and Laboratory Medicine and

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http://dx.doi.org/10.1373/clinchem.2018.293886DOI Listing
March 2019
3 Reads

Correction.

Authors:

Clin Chem 2019 Mar;65(3):497

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http://dx.doi.org/10.1373/clinchem.2018.300566DOI Listing
March 2019
1 Read

Commentary.

Clin Chem 2019 Mar;65(3):381-382

Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Bristol, UK;

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http://dx.doi.org/10.1373/clinchem.2018.297325DOI Listing
March 2019
1 Read

Commentary.

Authors:
Mitchell G Scott

Clin Chem 2019 Mar;65(3):380-381

Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washing University School of Medicine, Saint Louis, MO.

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http://dx.doi.org/10.1373/clinchem.2018.297317DOI Listing
March 2019
2 Reads

A Brother and Sister with Fluctuating Potassium Concentrations.

Clin Chem 2019 Mar;65(3):378-380

Department of Clinical Chemistry, Isala Hospital, Zwolle, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2018.290775DOI Listing

Privacy in Direct-to-Consumer Genetic Testing.

Clin Chem 2019 Feb 28. Epub 2019 Feb 28.

Associate Professor of Philosophy, Purdue University Fort Wayne (IPFW), Fort Wayne, IN.

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http://dx.doi.org/10.1373/clinchem.2018.298935DOI Listing
February 2019
1 Read

Parameters for Validating a Hospital Pneumatic Tube System.

Clin Chem 2019 Feb 26. Epub 2019 Feb 26.

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University, St. Louis, MO;

Background: Pneumatic tube systems (PTSs) provide rapid transport of patient blood samples, but physical stress of PTS transport can damage blood cells and alter test results. Despite this knowledge, there is limited information on how to validate a hospital PTS.

Methods: We compared 2 accelerometers and evaluated multiple PTS routes. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301408DOI Listing
February 2019
2 Reads

Polygenic Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?

Clin Chem 2019 Feb 26. Epub 2019 Feb 26.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1373/clinchem.2018.296103DOI Listing
February 2019
1 Read

Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA.

Clin Chem 2019 Feb 21. Epub 2019 Feb 21.

IRCM, Institute of Research in Oncology of Montpellier, Montpellier, France;

Circulating cell-free DNA (cfDNA) isolated from blood has been identified as a potential biomarker in numerous fields, and has been the object of intensive research over the past decade, although its original discovery dates back 60 years. While it is already used routinely in commercial and clinical practice in oncology and prenatal testing, other potential applications have emerged, including for diabetes, cardiovascular diseases, organ transplantation, autoimmune diseases, sepsis, trauma, and sport management. As with the discovery and development of any biomarker, preanalytical requirements and documentation are as important as analytical requirements. Read More

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http://dx.doi.org/10.1373/clinchem.2018.298323DOI Listing
February 2019
2 Reads

A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.

Clin Chem 2019 Apr 19;65(4):530-539. Epub 2019 Feb 19.

Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

Background: Identification of unknown chemical entities is a major challenge in metabolomics. To address this challenge, we developed a comprehensive targeted profiling strategy, combining 3 complementary liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) techniques and in-house accurate mass retention time (AMRT) databases established from commercial standards. This strategy was used to evaluate the effect of nitisinone on the urinary metabolome of patients and mice with alkaptonuria (AKU). Read More

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http://dx.doi.org/10.1373/clinchem.2018.295345DOI Listing
April 2019
2 Reads
7.911 Impact Factor

Circulating microRNAs: In a Class of Their Own.

Authors:
Rossa W K Chiu

Clin Chem 2019 Feb 19. Epub 2019 Feb 19.

Li Ka Shing Institute of Health Sciences and Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1373/clinchem.2018.301051DOI Listing
February 2019
2 Reads

Measurement of Treatment Effects Require Instruments Responsive to Change Based on the Minimal Important Difference.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada;

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http://dx.doi.org/10.1373/clinchem.2018.290817DOI Listing
February 2019