23,926 results match your criteria Clinical Chemistry[Journal]


Measurement of Treatment Effects Require Instruments Responsive to Change Based on the Minimal Important Difference.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.290817DOI Listing
February 2019

Increased Clinical Sensitivity and Specificity of Plasma Protein -Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection-Electrospray Ionization-Quadrupole Time-of-Flight Mass Spectrometry.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA

Background: Congenital disorders of glycosylation (CDG) represent 1 of the largest groups of metabolic disorders with >130 subtypes identified to date. The majority of CDG subtypes are disorders of -linked glycosylation, in which carbohydrate residues, namely, -glycans, are posttranslationally linked to asparagine molecules in peptides. To improve the diagnostic capability for CDG, we developed and validated a plasma -glycan assay using flow injection-electrospray ionization-quadrupole time-of-flight mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.296780DOI Listing
February 2019

Technology Meets Opportunity: High-Sensitivity Troponin Testing for Screening Apparently Healthy Adults.

Authors:
James A de Lemos

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Division of Cardiology, University of Texas Southwestern Medical Center, Dallas TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298695DOI Listing
February 2019

Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry, The University of Texas at Austin, Austin, TX

Background: Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.299289DOI Listing
February 2019

Room Temperature Detection of Plasma Epstein-Barr Virus DNA with CRISPR-Cas13.

Clin Chem 2019 Feb 12. Epub 2019 Feb 12.

Sun Yat-Sen UniversityCancer Center State Key Laboratory of OncologySouth China Collaborative Innovation Centerfor Cancer Medicine, Guangzhou China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.299347DOI Listing
February 2019

Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals.

Clin Chem 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark

Background: HDL is quantitatively the most important lipoprotein in most species and mechanistic evidence points toward a role for HDL in normal immune function. We tested the hypothesis that concentrations of HDL cholesterol are associated with risk of autoimmune disease.

Methods: From 2 studies of the general population- the Copenhagen General Population Study and the Co-penhagen City Heart study-we included 107954 and 9387 individuals with baseline measurements of HDL cholesterol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.299636DOI Listing
February 2019

Advancing Point-of-Care Diagnostics of Metabolites Through Engineering Semisynthetic Proteins.

Clin Chem 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemistry, Beckman Institute for Advanced Science and Technology, Uni- versity of Illinois at Urbana-Champaign, Urbana, IL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298836DOI Listing
February 2019

Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products.

Clin Chem 2019 Feb 8. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany;

Introduction: Circulating tumor cells (CTCs) may be used to improve cancer diagnosis, prognosis, and treatment. However, because knowledge regarding CTC biology is limited and the numbers of CTCs and CTC-positive cancer patients are low, progress in this field is slow. We addressed this limitation by combining diagnostic leukapheresis (DLA) and microfluidic enrichment to obtain large numbers of viable CTCs from metastasized breast cancer patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.296814DOI Listing
February 2019
1 Read

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Clin Chem 2019 Feb 8. Epub 2019 Feb 8.

Professor, Department of Chemistry, Purdue University, West Lafayette, IN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.289694DOI Listing
February 2019

Novel Assay for Quantitative Analysis of DNA Methylation at Single-Base Resolution.

Clin Chem 2019 Feb 8. Epub 2019 Feb 8.

Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China;

Background: The DNA methylation profile provides valuable biological information with potential clinical utility. Several methods, such as quantitative methylation-specific PCR (qMSP), have been developed to examine methylation of specific CpG sites. Existing qMSP-based techniques fail to examine the genomic methylation at a single-base resolution, particularly for loci in gene bodies or extensive CpG open seas lacking flanking CpGs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298570DOI Listing
February 2019

Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model () for Prostate Cancer in Cell-Free Urine.

Clin Chem 2019 Feb 6. Epub 2019 Feb 6.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

Background: Detection of prostate cancer (PC) based on serum prostate-specific antigen (PSA) testing leads to many unnecessary prostate biopsies, overdiagnosis, and overtreatment of clinically insignificant tumors. Thus, novel and more accurate molecular biomarkers are required.

Methods: Using reverse transcription quantitative PCR, we measured the concentrations of 45 preselected microRNAs (miRNAs) in extracellular vesicle-enriched cell-free urine samples from 4 independent patient cohorts from Spain and Denmark, including 758 patients with clinically localized PC, 289 noncancer controls with benign prostatic hyperplasia (BPH), and 233 patients undergoing initial transrectal ultrasound (TRUS)-guided prostate biopsy owing to PC suspicion (101 with benign and 132 with malignant outcome). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.296681DOI Listing
February 2019

Immunoglobulin-like Domain of FcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies.

Clin Chem 2019 Feb 1. Epub 2019 Feb 1.

Diagnostics Development Laboratory, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;

Background: The cellular surface molecule TOSO/FAIM3/Fcμ R has been identified as an IgM-specific Fc receptor expressed on lymphocytes. Here, we show that its extracellular immunoglobulin-like domain (Fcμ R-Igl) specifically binds to IgM/antigen immune complexes (ICs) and exploit this property for the development of novel detection systems for IgM antibodies directed against Crimean-Congo hemorrhagic fever virus (CCHFV) and Zika virus (ZIKV).

Methods: His-tagged Fcμ R-Igl was expressed in and purified by affinity chromatography, oxidative refolding, and size-exclusion chromatography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.294819DOI Listing
February 2019

Serendipity in Science: The Unexpected Tie.

Authors:
Ross T Barnard

Clin Chem 2019 Feb;65(2):358-359

School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297770DOI Listing
February 2019

Unexpected Pregnancy Test Results.

Authors:
Samuel I McCash

Clin Chem 2019 Feb;65(2):356

Memorial Sloan Kettering Cancer Center, New York, NY.

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.294
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.294959DOI Listing
February 2019
1 Read

Severe Hyperkalemia in a Hematology-Oncology Patient.

Clin Chem 2019 Feb;65(2):354-355

Department of Hemato-oncology, Faculty Hospital in Pilsen, Pilsen, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.290387DOI Listing
February 2019
1 Read

Hyperinsulinemic Hypoglycemia in a Neonate.

Clin Chem 2019 Feb;65(2):351-353

Department of Metabolic Biochemistry, Rouen University Hospital, Rouen, France;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.292326DOI Listing
February 2019
1 Read

Commentary.

Authors:
Deborah French

Clin Chem 2019 Feb;65(2):241

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297366DOI Listing
February 2019

Commentary.

Clin Chem 2019 Feb;65(2):240-241

Clinical Laboratories, Brigham and Women's Hospital, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297358DOI Listing
February 2019

A Question of Opioid Diversion or Compliance.

Clin Chem 2019 Feb;65(2):236-240

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.294140DOI Listing
February 2019

Can Mendelian Randomization Shift into Reverse Gear?

Clin Chem 2019 Jan 28. Epub 2019 Jan 28.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.296806DOI Listing
January 2019

Estimates of Within-Subject Biological Variation Derived from Pathology Databases: An Approach to Allow Assessment of the Effects of Age, Sex, Time Between Sample Collections, and Analyte Concentration on Reference Change Values.

Clin Chem 2019 Jan 28. Epub 2019 Jan 28.

Department of Chemical Pathology, St. Vincent's Hospital, Sydney, Darlinghurst, NSW, Australia;

Background: Within-subject biological variation data (CV) are used to establish quality requirements for assays and allow calculation of the reference change value (RCV) for quantitative clinical laboratory tests. The CV is generally determined using a large number of samples from a small number of individuals under controlled conditions. The approach presented here is to use a small number of samples (n = 2) that have been collected for routine clinical purposes from a large number of individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.290841DOI Listing
January 2019

Protein Detection by Counting Molecules.

Clin Chem 2019 Jan 28. Epub 2019 Jan 28.

Harvard Medical School, Department of Pathology, Brigham and Women's Hospital, and Wyss Institute for Bioinspired Engineering at Harvard University, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298653DOI Listing
January 2019

Increased Growth Differentiation Factor 15 Is Associated with Unfavorable Clinical Outcomes of Acute Ischemic Stroke.

Clin Chem 2019 Jan 24. Epub 2019 Jan 24.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.

Background: Growth differentiation factor 15 (GDF-15), a stress-responsive biomarker, is known to be independently associated with mortality and cardiovascular events in different disease settings, but data on the prognostic value of GDF-15 after stroke are limited.

Methods: Baseline serum GDF-15 was measured in 3066 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The primary outcome was a composite of death and major disability within 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297879DOI Listing
January 2019

Quality Monitoring of a FIT-Based Colorectal Cancer Screening Program.

Clin Chem 2019 Jan 16. Epub 2019 Jan 16.

Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Background: Quality assessment is crucial for consistent program performance of colorectal cancer (CRC) screening programs using fecal immunochemical test for hemoglobin (FIT). However, literature on the consistency of FIT performance in laboratory medicine was lacking. This study examined the consistency of FIT in testing positive or detecting advanced neoplasia (AN) for different specimen collection devices, lot reagents, and laboratories. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.294
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.294041DOI Listing
January 2019
5 Reads

Which Methods for Determining Glomerular Filtration Rate Most Strongly Associate with Risk of Progression of Kidney Disease?

Clin Chem 2019 Jan 15. Epub 2019 Jan 15.

Cedars Sinai Medical Center, Los Angeles, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.300731DOI Listing
January 2019
1 Read

How Does the Analytical Quality of the High-Sensitivity Cardiac Troponin T Assay Affect the ESC Rule Out Algorithm for NSTEMI?

Clin Chem 2019 Jan 15. Epub 2019 Jan 15.

Department of Medical Biochemistry and PharmacologyHaukeland University HospitalBergen, Norway

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298703DOI Listing
January 2019
1 Read

Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS.

Clin Chem 2019 Jan 15. Epub 2019 Jan 15.

Division of Nephrology, Tufts Medical Center, Boston, MA;

Background: Clinical practice guidelines recommend estimation of glomerular filtration rate (eGFR) using validated equations based on serum creatinine (eGFRcr), cystatin C (eGFRcys), or both (eGFRcr-cys). However, when compared with the measured GFR (mGFR), only eGFRcr-cys meets recommended performance standards. Our goal was to develop a more accurate eGFR method using a panel of metabolites without creatinine, cystatin C, or demographic variables. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.288
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.288092DOI Listing
January 2019
3 Reads

Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with increasing incidence and high mortality rates. MCC has recently become the subject of immune checkpoint therapy, but reliable biomarkers for estimating prognosis, risk stratification, and prediction of response are missing.

Methods: Circulating tumor cells (CTCs) were detected in peripheral blood from patients with MCC by use of the CellSearch® system. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.297
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.297028DOI Listing
January 2019
8 Reads

Toward a Future of Rapid, Low-Cost, Multiplexed Detection of Antimicrobial Resistance Markers for Tuberculosis and Other Pathogens.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

London Centre for Nanotechnology, University College London, London, UK;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.296715DOI Listing
January 2019
2 Reads

Cell-Free DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany;

Background: Novel targeted treatments and immunotherapies have substantially changed therapeutic options for advanced and metastatic RCCs (RCCs). However, accurate diagnostic tests for the identification of high-risk patients are urgently needed. Here, we analyzed SHOX2 mRNA expression in RCC tissues and gene body methylation quantitatively in circulating cell-free DNA (ccfDNA) and RCC tissues with regard to risk stratification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297549DOI Listing
January 2019
2 Reads

Predicting Acute Myocardial Infarction with a Single Blood Draw.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland;

Background: We desired to determine cardiac troponin (cTn) concentrations necessary to achieve a positive predictive value (PPV) of ≥75% for acute myocardial infarction (AMI) to justify immediate admission of patients to a monitored unit and, in general, early coronary angiography.

Methods: In a prospective multicenter diagnostic study enrolling patients presenting to the emergency department with symptoms suggestive of AMI, final diagnoses were adjudicated by 2 independent cardiologists based on clinical information including cardiac imaging. cTn concentrations were measured using 5 different sensitive and high-sensitivity cTn (hs-cTn) assays in a blinded fashion at presentation and serially thereafter. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.294
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.294124DOI Listing
January 2019
9 Reads

Trueness Evaluation and Verification of Interassay Agreement of 11 Serum IgA Measuring Systems: Implications for Medical Decisions.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy.

Background: To identify an IgA deficiency, the availability of reliable IgA lower reference limits is essential, especially in pediatrics. In this study, we reported the results of an intercomparison study aimed to verify the status of standardization of IgA measurements using 11 commercially available measuring systems (MSs).

Methods: After confirming its commutability, the ERM- DA470k/IFCC reference material was used for the trueness evaluation of IgA MSs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.297655DOI Listing
January 2019
2 Reads

Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK;

Background: The universal definition of myocardial infarction (UDMI) standardizes the approach to the diagnosis and management of myocardial infarction. High-sensitivity cardiac troponin testing is recommended because these assays have improved precision at low concentrations, but concerns over specificity may have limited their implementation.

Methods: We undertook a global survey of 1902 medical centers in 23 countries evenly distributed across 5 continents to assess adoption of key recommendations from the UDMI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298059DOI Listing
January 2019
2 Reads

Measuring the Turnover Rate of Clinically Important Plasma Proteins using an Automated SISCAPA Workflow.

Clin Chem 2019 Jan 9. Epub 2019 Jan 9.

Biomedicine Design, Worldwide Research & Development, Pfizer Inc. Andover, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.294892DOI Listing
January 2019
1 Read

Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays.

Clin Chem 2019 Jan 7. Epub 2019 Jan 7.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.298638DOI Listing
January 2019
1 Read

Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome.

Clin Chem 2019 Jan 3. Epub 2019 Jan 3.

Associate Professor, Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2017.284331DOI Listing
January 2019
2 Reads

Say "NO" to Erectile Dysfunction.

Authors:
Usha Anand

Clin Chem 2019 Jan;65(1):215-216

Anand Diagnostic Laboratory, Bangalore, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.287151DOI Listing
January 2019
1 Read

Evolution of Sperm Testing-A Bright Future?

Clin Chem 2019 Jan;65(1):212-214

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.289
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.289918DOI Listing
January 2019
5 Reads

Highest Testosterone Concentration Ever: Pathology or Laboratory Error?

Clin Chem 2019 Jan;65(1):210-211

Washington University in St. Louis, St. Louis, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.291468DOI Listing
January 2019
3 Reads
7.911 Impact Factor

The Vaginal Microbiome of Transgender Men.

Clin Chem 2019 Jan;65(1):199-207

University of Washington, Department of Laboratory Medicine, Seattle, WA;

Background: Hormonal changes influence the composition of vaginal flora, which is directly related to the health of an individual. Transgender men prescribed testosterone experience a vaginal hormone composition that differs from cisgender women. To the author's knowledge, there are no clinical studies evaluating the influence that testosterone administration has on the vaginal microbiome. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.293
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.293654DOI Listing
January 2019
2 Reads

Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage.

Clin Chem 2019 Jan;65(1):161-169

Section of Investigative Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK;

Background: Recurrent pregnancy loss, (RPL) affecting 1%-2% of couples, is defined as ≥3 consecutive pregnancy losses before 20-week' gestation. Women with RPL are routinely screened for etiological factors, but routine screening of male partners is not currently recommended. Recently it has been suggested that sperm quality is reduced in male partners of women with RPL, but the reasons underlying this lower quality are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.289348DOI Listing
January 2019
1 Read
7.911 Impact Factor

Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods.

Clin Chem 2019 Jan;65(1):153-160

Contraceptive Development Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.

Background: Development of new methods of male contraception would address an unmet need for men to control their fertility and could increase contraceptive options for women. Pharmaceutical research and development for male contraception was active in the 1990s but has been virtually abandoned. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a contraceptive development program since 1969 and supports the majority of hormonal male contraceptive development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.295089DOI Listing
January 2019
1 Read

Impact of Paternal Age at Conception on Human Health.

Clin Chem 2019 Jan;65(1):146-152

Centre Intersectoriel en Santé Durable, Université du Québec à Chicoutimi, Chicoutimi, Canada.

Background: The effect of maternal age at conception on various aspects of offspring health is well documented and often discussed. We seldom hear about the paternal age effect on offspring health, although the link is now almost as solid as with maternal age. The causes behind this, however, are drastically different between males and females. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.294421DOI Listing
January 2019
2 Reads

Effects of Gender-Affirming Hormones on Lipid, Metabolic, and Cardiac Surrogate Blood Markers in Transgender Persons.

Clin Chem 2019 Jan;65(1):119-134

Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.

Background: Gender-affirming hormonal therapy consists of testosterone in transgender men and estrogens and antiandrogens in transgender women. Research has concluded that gender-affirming therapy generally leads to high satisfaction rates, increased quality of life, and higher psychological well-being. However, given the higher incidence of cardiometabolic morbidity and mortality in cisgender men compared with cisgender women, concerns about the cardiometabolic risk of androgen therapy have been raised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.288241DOI Listing
January 2019
4 Reads

Circulating Tumor Cells in Prostate Cancer: From Discovery to Clinical Utility.

Clin Chem 2019 Jan;65(1):87-99

Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell College of Medicine, New York, NY.

Background: Prostate cancer represents the most common non-skin cancer type in men. Unmet needs include understanding prognosis to determine when intervention is needed and what type, prediction to guide the choice of a systemic therapy, and response indicators to determine whether a treatment is working. Over the past decade, the "liquid biopsy," characterized by the analysis of tumor cells and tumor cell products such as cell-free nucleic acids (DNA, microRNA) or extracellular vesicles circulating in the blood of cancer patients, has received considerable attention. Read More

View Article

Download full-text PDF

Source
http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.287
Publisher Site
http://dx.doi.org/10.1373/clinchem.2018.287102DOI Listing
January 2019
13 Reads

Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis.

Clin Chem 2019 Jan;65(1):57-66

Department of Laboratory Medicine, University of Washington, Seattle, WA;

Background: Transgender women are female individuals who were recorded men at birth based on natal sex. Supporting a person's gender identity improves their psychological health, and gender-affirming hormones reduce gender dysphoria and benefit mental health. For transgender women, estrogen administration has clinically significant benefits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.288316DOI Listing
January 2019
1 Read

Commentary.

Clin Chem 2019 Jan;65(1):55-56

Beth Israel Deaconess Medical Center, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.295196DOI Listing
January 2019
1 Read

Commentary.

Authors:
Jim D Faix

Clin Chem 2019 Jan;65(1):54-55

Montefiore Medical Center, Bronx, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.295188DOI Listing
January 2019
1 Read

An Unusual Case of Decompensated Heart Failure in a Young Man.

Clin Chem 2019 Jan;65(1):51-54

Department of Medicine, Washington University in St. Louis. St. Louis, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.291559DOI Listing
January 2019
1 Read