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    1425 results match your criteria Clinical Autonomic Research[Journal]

    1 OF 29

    First symptoms in multiple system atrophy.
    Clin Auton Res 2018 Jan 8. Epub 2018 Jan 8.
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL, 32224, USA.
    Purpose: The initial symptoms of multiple system atrophy (MSA) and, in particular, early autonomic symptoms, have received less attention than motor symptoms. Whereas pathognomonic motor signs are essential to diagnostic specificity, early symptoms important to recognition of a neurodegenerative disorder may be less apparent or diagnostically ambiguous. This observational study sought to identify the very earliest symptoms in the natural history of MSA. Read More

    Cardiovascular autonomic dysfunction in sudden infant death syndrome.
    Clin Auton Res 2018 Jan 3. Epub 2018 Jan 3.
    The Ritchie Centre, Department of Paediatrics and Hudson Institute of Medical Research, Monash University, Melbourne, Australia.
    A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep. Read More

    The physical examination as a window into autonomic disorders.
    Clin Auton Res 2018 Jan 2. Epub 2018 Jan 2.
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
    Signs of autonomic dysfunction, although at times seemingly mysterious, can contribute to diagnostic clarification and clinical investigation. Even when sophisticated autonomic testing equipment is not readily available, the experienced clinician, through educated observation and inductive reasoning-in conjunction with an intelligently obtained autonomic medical history-can discern much by a careful physical examination. Elements of the autonomic examination include variations in the pulse, postural measurements of blood pressure and heart rate, pupillary light reactions, skin coloration and temperature, patterns of sweating, and other organ-specific physical findings relevant to the individual patient's presentation. Read More

    Seronegative autoimmune autonomic neuropathy: a distinct clinical entity.
    Clin Auton Res 2017 Dec 26. Epub 2017 Dec 26.
    Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
    Purpose: Autoimmune autonomic ganglionopathy (AAG) is associated with ganglionic acetylcholine receptor (gAChR) antibodies. We describe a similar but distinct series of patients with autoimmune autonomic failure lacking this antibody.

    Methods: Retrospective chart review. Read More

    The endocannabinoid system in cardiovascular function: novel insights and clinical implications.
    Clin Auton Res 2017 Dec 8. Epub 2017 Dec 8.
    Neurology Service, Electromyography, Motor Control and Neuropathic Pain Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.
    Rationale: Cardiovascular disease is now recognized as the number one cause of death in the world, and the size of the population at risk continues to increase rapidly. The dysregulation of the endocannabinoid (eCB) system plays a central role in a wide variety of conditions including cardiovascular disorders. Cannabinoid receptors, their endogenous ligands, as well as enzymes conferring their synthesis and degradation, exhibit overlapping distributions in the cardiovascular system. Read More

    Correction to: Electrocardiogram-based predictors for arrhythmia after spinal cord injury.
    Clin Auton Res 2017 Dec 4. Epub 2017 Dec 4.
    Department of Biomedical Physiology and Kinesiology, Faculty of Science, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
    There is a typographical error in the formula presented for QTVI. While the formula was correctly applied to the data presented, the description of the formula has an incorrectly placed parenthesis. It should read. Read More

    The hemodynamic and pain impact of peripheral nerve block versus spinal anesthesia in diabetic patients undergoing diabetic foot surgery.
    Clin Auton Res 2017 Dec 1. Epub 2017 Dec 1.
    Department of Anaesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
    Purpose: Comparison of hemodynamic profiles and pain scores in diabetic patients undergoing diabetic foot surgery receiving peripheral nerve block (PNB) or spinal anesthesia [subarachnoid block (SAB)].

    Methods: This was a prospective, randomised controlled trial. We recruited diabetic patients aged > 18 years, American Society of Anesthesiologists class II-III, who were scheduled for unilateral diabetic foot surgery below the knee. Read More

    Urological dysfunction in synucleinopathies: epidemiology, pathophysiology and management.
    Clin Auton Res 2017 Nov 9. Epub 2017 Nov 9.
    Continence Center, Dokkyo Medical College, Mibu, Japan.
    Objective: Parkinson's disease (PD) and multiple system atrophy (MSA) are major neurogenerative diseases characterized pathologically by abnormal alpha-synuclein aggregation. PD and MSA are clinically characterized by motor disorder and bladder dysfunction (mainly urinary urgency and frequency, also called overactive bladder). However, few literatures are available concerning bladder dysfunction in PD or MSA. Read More

    The "sacral parasympathetic": ontogeny and anatomy of a myth.
    Clin Auton Res 2017 Nov 4. Epub 2017 Nov 4.
    Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005, Paris, France.
    We recently defined genetic traits that distinguish sympathetic from parasympathetic neurons, both preganglionic and ganglionic (Espinosa-Medina et al., Science 354:893-897, 2016). By this set of criteria, we found that the sacral autonomic outflow is sympathetic, not parasympathetic as has been thought for more than a century. Read More

    Cardiovascular autonomic effects of vagus nerve stimulation.
    Clin Auton Res 2017 Oct 25. Epub 2017 Oct 25.
    Autonomic and Movement Disorders Unit, Biocruces Research Institute, Barakaldo, Bizkaia, Spain.
    The vagus nerve is responsible for the parasympathetic innervation of the major thoracic and abdominal organs. It also carries sensory afferent fibres from these viscera and reaches different brain structures. These connections have proven useful in the treatment of different diseases. Read More

    Carotid artery reactivity during sympathetic activation following acute resistance exercise.
    Clin Auton Res 2017 Dec 19;27(6):417-421. Epub 2017 Oct 19.
    Department of Sport Science, University of Seoul, Seoul, 130-743, South Korea.
    Objective: Acute resistance exercise has been shown to reduce brachial endothelial function. Whether there are concomitant reductions in carotid endothelial function remains unexplored.

    Methods: Cold pressor test-mediated vasodilation of the carotid artery was used to assess carotid endothelial function in 15 young and healthy participants (age 26 ± 1 years, body mass index 24 ± 1 kg/m2) after acute resistance exercise or an inactive time control condition. Read More

    Beat-to-beat blood pressure and heart rate responses to the Valsalva maneuver.
    Clin Auton Res 2017 Dec 19;27(6):361-367. Epub 2017 Oct 19.
    Department of Neurology, Mayo Clinic, Jacksonville, FL, 32224, USA.
    Measurement of beat-to-beat blood pressure and heart rate responses to the Valsalva maneuver is the basis for a highly informative autonomic function test. Whereas in the past this measurement required intra-arterial cannulation, the development of finger cuff devices that acquire arterial pressure waveforms indistinguishable from those recorded intra-arterially has made it possible to obtain accurate measurements noninvasively. In a patient with orthostatic hypotension, the pattern of blood pressure responses during and after the release of the maneuver can identify a neurogenic basis: sympathetic neurocirculatory failure. Read More

    The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.
    Clin Auton Res 2017 Oct 10. Epub 2017 Oct 10.
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126, Bologna, Italy.
    Narcolepsy is a rare disease that entails excessive daytime sleepiness, often associated with sudden episodes of muscle weakness known as cataplexy. Narcolepsy with cataplexy (NC) is due to the loss of hypothalamic neurons that release the neuropeptides orexin A and B. Orexin neuron projections prominently target brain structures involved in wake-sleep state switching and the central autonomic network. Read More

    Long-term anabolic steroids in male bodybuilders induce cardiovascular structural and autonomic abnormalities.
    Clin Auton Res 2017 Oct 10. Epub 2017 Oct 10.
    Department of Physiology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
    Objective: The aims of this study were to examine the hypothesis that users of anabolic androgenic steroids (AAS) would have cardiac autonomic disorders and that there is a correlation between sympathetic modulation, high blood pressure (BP) and alterations to cardiac dimensions.

    Methods: Forty-five male subjects were enrolled in the study. They were categorized into three groups comprising bodybuilders actively using AAS (AAS users; n = 15), bodybuilders who had never used AAS (nonusers; n = 15) and age-paired healthy sedentary controls (n = 15). Read More

    Electrochemical skin conductance: a systematic review.
    Clin Auton Res 2017 Sep 26. Epub 2017 Sep 26.
    Autonomic Laboratory, Department of Neurology, Brigham and Women's Faulkner Hospital, Harvard Medical School, 1153 Centre Street, Boston, MA, 02103, USA.
    Purpose: Currently available techniques for the evaluation of small fiber neuropathy and related sudomotor function remain suboptimal. Electrochemical skin conductance (ESC) has recently been introduced as a simple noninvasive and fast method for the detection of sudomotor dysfunction. The purpose of this review is to synthesize and appraise research using ESC measurements for sudomotor evaluation in adults. Read More

    The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications.
    Clin Auton Res 2017 Sep 23. Epub 2017 Sep 23.
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark.
    The hallmark of primary headaches belonging to the group known as the trigeminal autonomic cephalalgias is unilateral headache accompanied by cranial autonomic symptoms. Being relatively rare and poorly understood, they represent a clinical challenge, leading to underdiagnosis and undertreatment. While the headache is the most obvious and disabling symptom, it is only part of a complex symptomatology which hints at the involved pathophysiological mechanisms. Read More

    Risk reduction of long-term major adverse cardiovascular events after endoscopic thoracic sympathectomy in palmar hyperhidrosis.
    Clin Auton Res 2017 Dec 19;27(6):393-400. Epub 2017 Sep 19.
    Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, 7115R, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
    Purpose: Palmar hyperhidrosis (PH) is excessive sweating of the palms resulting from sympathetic overactivity, and patients who undergo endoscopic thoracic sympathectomy (ETS) show reduced cardiac demand after 1 year and improved cerebral perfusion within 2-4 weeks. However, the long-term risks of major adverse cardiovascular events (MACE) following ETS remain unclear.

    Methods: We searched the Longitudinal National Health Insurance Database in Taiwan and identified PH patients (International Classification of Disease, Ninth Revision, Clinical Modification diagnostic code 708. Read More

    Epidemiology, pathogenesis, and management of takotsubo syndrome.
    Clin Auton Res 2017 Sep 15. Epub 2017 Sep 15.
    Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
    Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Read More

    Recruitment strategies in efferent sympathetic nerve activity.
    Clin Auton Res 2017 Dec 4;27(6):369-378. Epub 2017 Sep 4.
    School of Kinesiology, The University of Western Ontario, Room 3159C Thames Hall, 1151 Richmond St. N., London, ON, N6A 3K7, Canada.
    In 1968, the first reported microneurographic recordings of muscle sympathetic nerve activity (MSNA) in humans revealed the bursty behavior of efferent sympathetic nerve activity. The timing of bursts could be explained by baroreflex physiology, but the variability in size of each burst was left unexplained. On the basis of shorter latencies of larger bursts, Wallin's group [53] proposed the existence of variable supraspinal synaptic delays and/or options for recruitment of faster-conducting sympathetic neurons when bursts become stronger. Read More

    REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?
    Clin Auton Res 2017 Sep 4. Epub 2017 Sep 4.
    Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, Via Altura, 3, 40139, Bologna, Italy.
    Introduction: From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Read More

    Pupillary autonomic dysfunction in patients with ANCA-associated vasculitis.
    Clin Auton Res 2017 Dec 1;27(6):385-392. Epub 2017 Sep 1.
    Medizinische Klinik IV, Rheumaeinheit, Klinikum der Universität München, Munich, Germany.
    Objective: To assess autonomic function by infrared dynamic pupillometry in patients with ANCA-vasculitis (AAV) in correlation to autonomic symptoms, disease specific clinical parameters and cardiovascular reflex tests.

    Methods: Patients with AAV and healthy controls underwent pupillometry at rest and after sympathetic stimulation (cold pressor test). Three parasympathetic parameters (amplitude, relative amplitude, maximum constriction velocity) and one sympathetic parameter (late dilatation velocity) were assessed. Read More

    The Etiology of Primary Hyperhidrosis: A Systematic Review.
    Clin Auton Res 2017 Dec 19;27(6):379-383. Epub 2017 Aug 19.
    Department of Cardiothoracic Surgery, Odense University Hospital, Odense, 5000, Denmark.
    Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Read More

    Transcranial Doppler in autonomic testing: standards and clinical applications.
    Clin Auton Res 2017 Aug 18. Epub 2017 Aug 18.
    Department of Neurology, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Palmer 127, Boston, MA, 02215, USA.
    When cerebral blood flow falls below a critical limit, syncope occurs and, if prolonged, ischemia leads to neuronal death. The cerebral circulation has its own complex finely tuned autoregulatory mechanisms to ensure blood supply to the brain can meet the high metabolic demands of the underlying neuronal tissue. This involves the interplay between myogenic and metabolic mechanisms, input from noradrenergic and cholinergic neurons, and the release of vasoactive substrates, including adenosine from astrocytes and nitric oxide from the endothelium. Read More

    Influence of sex, menstrual cycle, and oral contraceptives on the cerebrovascular response to paced deep breathing.
    Clin Auton Res 2017 Dec 1;27(6):411-415. Epub 2017 Aug 1.
    School of Kinesiology and Health Sciences, York University, 355 Bethune College, 4700 Keele St, Toronto, ON, M3J 1P3, Canada.
    Purpose: Deep breathing assesses autonomic function; however, many researchers/clinicians do not account for hyperventilation, brain blood flow or blood pressure.

    Methods: Men and women (with/without oral contraceptives) participated. women participated during low and high hormone phases of the menstrual cycle. Read More

    Infectious diseases causing autonomic dysfunction.
    Clin Auton Res 2017 Jul 20. Epub 2017 Jul 20.
    Neurology Department, Raigmore Hospital, Inverness, UK.
    Objectives: To review infectious diseases that may cause autonomic dysfunction.

    Methods: Review of published papers indexed in medline/embase.

    Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

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