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    1394 results match your criteria Clinical Autonomic Research[Journal]

    1 OF 28

    Risk reduction of long-term major adverse cardiovascular events after endoscopic thoracic sympathectomy in palmar hyperhidrosis.
    Clin Auton Res 2017 Sep 19. Epub 2017 Sep 19.
    Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, 7115R, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
    Purpose: Palmar hyperhidrosis (PH) is excessive sweating of the palms resulting from sympathetic overactivity, and patients who undergo endoscopic thoracic sympathectomy (ETS) show reduced cardiac demand after 1 year and improved cerebral perfusion within 2-4 weeks. However, the long-term risks of major adverse cardiovascular events (MACE) following ETS remain unclear.

    Methods: We searched the Longitudinal National Health Insurance Database in Taiwan and identified PH patients (International Classification of Disease, Ninth Revision, Clinical Modification diagnostic code 708. Read More

    Epidemiology, pathogenesis, and management of takotsubo syndrome.
    Clin Auton Res 2017 Sep 15. Epub 2017 Sep 15.
    Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
    Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Read More

    Recruitment strategies in efferent sympathetic nerve activity.
    Clin Auton Res 2017 Sep 4. Epub 2017 Sep 4.
    School of Kinesiology, The University of Western Ontario, Room 3159C Thames Hall, 1151 Richmond St. N., London, ON, N6A 3K7, Canada.
    In 1968, the first reported microneurographic recordings of muscle sympathetic nerve activity (MSNA) in humans revealed the bursty behavior of efferent sympathetic nerve activity. The timing of bursts could be explained by baroreflex physiology, but the variability in size of each burst was left unexplained. On the basis of shorter latencies of larger bursts, Wallin's group [53] proposed the existence of variable supraspinal synaptic delays and/or options for recruitment of faster-conducting sympathetic neurons when bursts become stronger. Read More

    REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?
    Clin Auton Res 2017 Sep 4. Epub 2017 Sep 4.
    Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, Via Altura, 3, 40139, Bologna, Italy.
    Introduction: From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Read More

    Pupillary autonomic dysfunction in patients with ANCA-associated vasculitis.
    Clin Auton Res 2017 Sep 1. Epub 2017 Sep 1.
    Medizinische Klinik IV, Rheumaeinheit, Klinikum der Universität München, Munich, Germany.
    Objective: To assess autonomic function by infrared dynamic pupillometry in patients with ANCA-vasculitis (AAV) in correlation to autonomic symptoms, disease specific clinical parameters and cardiovascular reflex tests.

    Methods: Patients with AAV and healthy controls underwent pupillometry at rest and after sympathetic stimulation (cold pressor test). Three parasympathetic parameters (amplitude, relative amplitude, maximum constriction velocity) and one sympathetic parameter (late dilatation velocity) were assessed. Read More

    The Etiology of Primary Hyperhidrosis: A Systematic Review.
    Clin Auton Res 2017 Aug 19. Epub 2017 Aug 19.
    Department of Cardiothoracic Surgery, Odense University Hospital, Odense, 5000, Denmark.
    Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Read More

    Transcranial Doppler in autonomic testing: standards and clinical applications.
    Clin Auton Res 2017 Aug 18. Epub 2017 Aug 18.
    Department of Neurology, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Palmer 127, Boston, MA, 02215, USA.
    When cerebral blood flow falls below a critical limit, syncope occurs and, if prolonged, ischemia leads to neuronal death. The cerebral circulation has its own complex finely tuned autoregulatory mechanisms to ensure blood supply to the brain can meet the high metabolic demands of the underlying neuronal tissue. This involves the interplay between myogenic and metabolic mechanisms, input from noradrenergic and cholinergic neurons, and the release of vasoactive substrates, including adenosine from astrocytes and nitric oxide from the endothelium. Read More

    Influence of sex, menstrual cycle, and oral contraceptives on the cerebrovascular response to paced deep breathing.
    Clin Auton Res 2017 Aug 1. Epub 2017 Aug 1.
    School of Kinesiology and Health Sciences, York University, 355 Bethune College, 4700 Keele St, Toronto, ON, M3J 1P3, Canada.
    Purpose: Deep breathing assesses autonomic function; however, many researchers/clinicians do not account for hyperventilation, brain blood flow or blood pressure.

    Methods: Men and women (with/without oral contraceptives) participated. women participated during low and high hormone phases of the menstrual cycle. Read More

    Infectious diseases causing autonomic dysfunction.
    Clin Auton Res 2017 Jul 20. Epub 2017 Jul 20.
    Neurology Department, Raigmore Hospital, Inverness, UK.
    Objectives: To review infectious diseases that may cause autonomic dysfunction.

    Methods: Review of published papers indexed in medline/embase.

    Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

    Heart-rate response to alpha2-adrenergic receptor antagonism by antipsychotics.
    Clin Auton Res 2017 Jul 3. Epub 2017 Jul 3.
    Department of Psychiatry, University of British Columbia, Room A3-111, 938 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
    Purpose: To explore the relationship between antipsychotic-associated antagonism of alpha2-adrenergic receptors and resting heart rate in individuals with schizophrenia.

    Methods: Thirty-one inpatients treated with antipsychotics were included in this exploratory analysis. Antipsychotic doses were converted to haloperidol equivalents for alpha2-adrenergic receptor antagonism. Read More

    Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study.
    Clin Auton Res 2017 Jul 3. Epub 2017 Jul 3.
    School of Science and Health, Western Sydney University, Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.
    Objective And Methods: Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.

    Results: Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. Read More

    Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia.
    Clin Auton Res 2017 Aug 3;27(4):279-282. Epub 2017 Jul 3.
    Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, NY, USA.
    Purpose: To report the use of intranasal dexmedetomidine, an α2-adrenergic agonist for the acute treatment of refractory adrenergic crisis in patients with familial dysautonomia.

    Methods: Case series.

    Results: Three patients with genetically confirmed familial dysautonomia (case 1: 20-year-old male; case 2: 43-year-old male; case 3: 26-year-old female) received intranasal dexmedetomidine 2 mcg/kg, half of the dose in each nostril, for the acute treatment of adrenergic crisis. Read More

    Vasovagal syncope with asystole: the role of cardiac pacing.
    Clin Auton Res 2017 Aug 1;27(4):245-251. Epub 2017 Jul 1.
    BIOTRONIK Italy S.p.A., Vimodrone, Italy.
    Whereas cardiac pacing has a very limited role overall in patients with vasovagal syncope (VVS), there are three reasons which support pacing efficacy in tilt-induced asystolic VVS. These are: (1) contrary to mixed and vasodepressor forms, an asystolic tilt response is specific, i.e. Read More

    Typical vasovagal syncope as a "defense mechanism" for the heart by contrasting sympathetic overactivity.
    Clin Auton Res 2017 Aug 1;27(4):253-261. Epub 2017 Jul 1.
    Department of Zoology and Anthropology, University of Sassari, Sassari, Italy.
    Many observations suggest that typical (emotional or orthostatic) vasovagal syncope (VVS) is not a disease, but rather a manifestation of a non-pathological trait. Some authors have hypothesized this type of syncope as a "defense mechanism" for the organism and a few theories have been postulated. Under the human violent conflicts theory, the VVS evolved during the Paleolithic era only in the human lineage. Read More

    Can syncope cause convulsive seizures in adults?
    Clin Auton Res 2017 Aug 30;27(4):283-287. Epub 2017 Jun 30.
    Epilepsy Service, Department of Neurology, Cork University Hospital, Cork, Ireland.
    Purpose: Convulsive epileptic seizures triggered by transient cerebral hypoperfusion 'reflex anoxic seizures' are well-described in children but are not commonly recognized in adults.

    Methods: We report a case series of 12 adults who presented acutely after generalized tonic-clonic seizures with a clear syncopal phase before the convulsion. We describe the aetiology, semiology and natural history of these events. Read More

    Animal and cellular models of familial dysautonomia.
    Clin Auton Res 2017 Aug 30;27(4):235-243. Epub 2017 Jun 30.
    Department of Biological and Physical Sciences, Montana State University Billings, Billings, MT, 59101, USA.
    Since Riley and Day first described the clinical phenotype of patients with familial dysautonomia (FD) over 60 years ago, the field has made considerable progress clinically, scientifically, and translationally in treating and understanding the etiology of FD. FD is classified as a hereditary sensory and autonomic neuropathy (HSAN type III) and is both a developmental and a progressive neurodegenerative condition that results from an autosomal recessive mutation in the gene IKBKAP, also known as ELP1. FD primarily impacts the peripheral nervous system but also manifests in central nervous system disruption, especially in the retina and optic nerve. Read More

    Reproducibility of 24-h heart rate variability in children.
    Clin Auton Res 2017 Aug 30;27(4):273-278. Epub 2017 Jun 30.
    Medical Faculty, University of Nis, Nis, Serbia.
    Background: Over the last decades, time domain heart rate (HR) variability analysis has been explored in different pediatric clinical settings to obtain information on the cardiac autonomic tone. However, the consistency over time of 24 h time domain HRV measurements in children is not well-known.

    Methods: We investigated the reproducibility of 24 h HRV time-domain indices (1 day apart), from 39 healthy children (9. Read More

    Postprandial hypotension in neurological disorders: systematic review and meta-analysis.
    Clin Auton Res 2017 Aug 24;27(4):263-271. Epub 2017 Jun 24.
    School of Medicine, University of Zagreb, Zagreb, Croatia.
    Purpose: Postprandial hypotension (PPH) has been associated with increased risk of syncope, falls, stroke, angina and mortality. As the majority of patients with PPH are asymptomatic, the diagnosis is often overlooked. The aim of this study was to perform a systematic review and meta-analysis of available scientific evidence on the likelihood of PPH in neurological diseases. Read More

    The autonomic medical history.
    Clin Auton Res 2017 Aug 27;27(4):223-233. Epub 2017 May 27.
    Department of Neurology, Mayo Clinic, Jacksonville, FL, 32224, USA.
    The most important autonomic function test-the autonomic medical history-is the patient's account, interpreted by a clinician skilled in asking the right questions, of symptoms during daily activities that relate to the autonomic nervous system. The chronology and pattern of these symptoms combine to create a portrait of autonomic function or dysfunction. We summarize the steps in obtaining a comprehensive autonomic medical history. Read More

    Autonomic control of body temperature and blood pressure: influences of female sex hormones.
    Clin Auton Res 2017 Jun 9;27(3):149-155. Epub 2017 May 9.
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.
    Female reproductive hormones exert important non-reproductive influences on autonomic regulation of body temperature and blood pressure. Estradiol and progesterone influence thermoregulation both centrally and peripherally, where estradiol tends to promote heat dissipation, and progesterone tends to promote heat conservation and higher body temperatures. Changes in thermoregulation over the course of the menstrual cycle and with hot flashes at menopause are mediated by hormonal influences on neural control of skin blood flow and sweating. Read More

    Baroreflex gain and vasomotor sympathetic modulation in resistant hypertension.
    Clin Auton Res 2017 Jun 6;27(3):175-184. Epub 2017 Apr 6.
    Cardiovascular Research Unit and Exercise Physiology, University Hospital and Faculty of Physical Education and Sports, Federal University of Juiz de Fora University Campus, Juiz de Fora, MG, Brazil.
    Purpose: The aim of this study was to determine the gain and latency of arterial baroreflex control of heart rate in patients with resistant hypertension compared to patients with essential hypertension and normotensive subjects.

    Methods: Eighteen patients with resistant hypertension (56 ± 10 years, mean of four antihypertensive drugs), 17 patients with essential hypertension (56 ± 11 years, mean of two antihypertensive drugs), and 17 untreated normotensive controls (50 ± 15 years) were evaluated by spectral analysis of the spontaneous fluctuations of arterial pressure (beat-to-beat) and heart rate (ECG). This analysis estimated vasomotor and cardiac autonomic modulations, respectively. Read More

    Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management.
    Clin Auton Res 2017 Apr 5. Epub 2017 Apr 5.
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
    Purpose: The aim of this study was to review the evidence on the epidemiology, physiopathology, categorization, and management of cholinergic urticaria. We specifically focused on several subtypes of cholinergic urticaria and investigated the relationship between cholinergic urticaria and idiopathic anhidrosis.

    Methods: Using an integrative approach, we reviewed publications addressing the epidemiology, clinical features, diagnostic approach, physiopathology, subtype classification, and therapeutic approach to cholinergic urticaria. Read More

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