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    19 results match your criteria Clinical Approaches in Bipolar Disorders [Journal]

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    The Lithium Battery: assessing the neurocognitive profile of lithium in bipolar disorder.
    Bipolar Disord 2016 Mar 23;18(2):102-15. Epub 2016 Mar 23.
    Academic Department of Psychiatry, Kolling Institute, Northern Sydney Local Health District, St. Leonards, Sydney, NSW, Australia.
    Objective: The aim of the present study was to characterize the neurocognitive effects of lithium in bipolar disorder to inform clinical and research approaches for further investigation.

    Methods: Key words pertaining to neurocognition in bipolar disorder and lithium treatment were used to search recognized databases to identify relevant literature. The authors also retrieved gray literature (e. Read More

    A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force.
    Bipolar Disord 2015 Nov 19;17(7):689-704. Epub 2015 Sep 19.
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
    Objectives: In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD).

    Methods: This task force report addresses the unique aspects of OABD including epidemiology and clinical features, neuropathology and biomarkers, physical health, cognition, and care approaches. Read More

    Advancing biomarker research: utilizing 'Big Data' approaches for the characterization and prevention of bipolar disorder.
    Bipolar Disord 2014 Aug 16;16(5):531-47. Epub 2013 Dec 16.
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
    Objective: To provide a strategic framework for the prevention of bipolar disorder (BD) that incorporates a 'Big Data' approach to risk assessment for BD.

    Methods: Computerized databases (e.g. Read More

    Stage managing bipolar disorder.
    Bipolar Disord 2014 Aug 20;16(5):471-7. Epub 2013 Jun 20.
    School of Medicine, Deakin University, Geelong; Department of Psychiatry, University of Melbourne, Melbourne, Vic., Australia; Orygen Youth Health, Melbourne, Vic., Australia; Florey Institute for Neuroscience and Mental Health, Melbourne, Vic., Australia.
    Objectives: Clinical staging is widespread in medicine - it informs prognosis, clinical course, and treatment, and assists individualized care. Staging places an individual on a probabilistic continuum of increasing potential disease severity, ranging from clinically at-risk or latency stage through first threshold episode of illness or recurrence, and, finally, to late or end-stage disease. The aim of the present paper was to examine and update the evidence regarding staging in bipolar disorder, and how this might inform targeted and individualized intervention approaches. Read More

    Pattern recognition analyses of brain activation elicited by happy and neutral faces in unipolar and bipolar depression.
    Bipolar Disord 2012 Jun;14(4):451-60
    Department of Computer Science, Centre for Computational Statistics and Machine Learning, University College London, London, UK.
    Objectives: Recently, pattern recognition approaches have been used to classify patterns of brain activity elicited by sensory or cognitive processes. In the clinical context, these approaches have been mainly applied to classify groups of individuals based on structural magnetic resonance imaging (MRI) data. Only a few studies have applied similar methods to functional MRI (fMRI) data. Read More

    Beating Bipolar: exploratory trial of a novel Internet-based psychoeducational treatment for bipolar disorder.
    Bipolar Disord 2011 Aug-Sep;13(5-6):571-7
    Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
    Objectives:   Psychoeducational approaches are promising interventions for the long-term management of bipolar disorder. In consultation with professionals, patients, and their families we have developed a novel web-based psychoeducational intervention for bipolar disorder called Beating Bipolar. We undertook a preliminary exploratory randomized trial to examine efficacy, feasibility and acceptability. Read More

    Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder.
    Bipolar Disord 2011 Aug-Sep;13(5-6):500-8
    Department of Clinical Neuroscience Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
    Objective:   Several genetic loci have been suggested to be associated with bipolar disorder but results have been inconsistent. Studying associations between bipolar symptoms and candidate genes may better expose this relationship. Here we investigate the association between bipolar key symptoms and the P2RX7 gene. Read More

    Early identification and high-risk strategies for bipolar disorder.
    Bipolar Disord 2007 Jun;9(4):324-38
    The Zucker Hillside Hospital, Psychiatry Research, North Shore - Long Island Jewish Health System, Glen Oaks, NY 11004, USA.
    Objectives: To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD).

    Methods: Selective review of data that support early identification in BPD, with a particular focus on emerging clinical high-risk strategies.

    Results: Early detection of individuals at risk for BPD can utilize genetic, endophenotypic and clinical methods. Read More

    Comorbidity of eating disorders with bipolar disorder and treatment implications.
    Bipolar Disord 2006 Dec;8(6):686-95
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
    Objectives: To review the scientific evidence examining the comorbidity among eating disorders and bipolar disorder (BD).

    Methods: We reviewed all published English-language studies addressing the comorbidity of anorexia nervosa, bulimia, bulimia nervosa, and binge eating disorder in patients with BD and studies of comorbidity of BD in patients with eating disorders. In addition, we discuss the pharmacologic treatment implications from reviewed studies of agents used in BD and eating disorders. Read More

    Pediatric bipolar disease: current and future perspectives for study of its long-term course and treatment.
    Bipolar Disord 2006 Aug;8(4):311-21
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024-1759, USA.
    Aim And Methods: Findings from recent long-term, prospective longitudinal studies of the course, outcome and naturalistic treatment of adults with bipolar illness are highlighted as background for long-term developmental study of pediatric bipolar illness.

    Results: Accumulating knowledge of bipolar illness in adults underscores a high risk for multiple recurrences through the lifespan, significant medical morbidity, high rates of self-harm, economic and social burden and frequent treatment resistance with residual symptoms between major episodes. At present, there is no empirical foundation to support any assumption about the long-term course or outcome of bipolar illness when it arises in childhood or adolescence, or the effects of conventional pharmacotherapies in altering its course and limiting potentially adverse outcomes. Read More

    Psychological therapies for bipolar disorder: the role of model-driven approaches to therapy integration.
    Bipolar Disord 2005 Feb;7(1):22-32
    Academic Division of Clinical Psychology, University of Manchester and Pennine Care Trust, Greater Manchester, UK.
    Objectives: The psychological and social aspects of bipolar disorder are receiving increasing recognition. Recently, there have been promising developments in psychological interventions, but there is scope for further improvement of therapeutic outcomes. This paper argues for the use of more detailed psychological models of bipolar disorder to inform the further development of therapeutic approaches. Read More

    A collaborative approach to the treatment alliance in bipolar disorder.
    Bipolar Disord 2004 Dec;6(6):504-18
    Department of Clinical and Biomedical Sciences, University of Melbourne, Melbourne, Victoria, Australia.
    Objectives: The treatment alliance is the arena in which psychopharmacological and other therapeutic interventions occur. The nature and quality of the treatment alliance may affect adherence to treatment and the realization of the benefits of effective pharmacological treatment in clinical practice. It is an area that has attracted little systematic study, despite the available evidence suggesting that it plays a measurable role in clinical outcomes. Read More

    Clinical consequences of under-recognized bipolar spectrum disorder.
    Bipolar Disord 2003 Dec;5(6):456-63
    Department of Psychiatry and Behavioral Sciences, Center for Anxiety and Depression, University of Washington School of Medicine, Seattle, WA 98105, USA.
    The prevalence of bipolar disorder is higher than previously believed, especially when bipolar spectrum disorders (BSD) are taken into account, and may approach rates as high as 5%. Difficulties in diagnosing bipolar II and BSD arise from complexities associated with defining and diagnosing hypomania. Additionally, bipolar disorder and BSD are often misdiagnosed because of symptoms that overlap with other psychiatric disorders, particularly unipolar depression. Read More

    An overview of recent findings of the Stanley Foundation Bipolar Network (Part I).
    Bipolar Disord 2003 Oct;5(5):310-9
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892-1272, USA.
    Aim And Methods: Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed.

    Results: Daily prospective ratings on the NIMH-LCM indicate a high degree of residual depressive morbidity (three times that of hypomania or mania) despite active psychopharmacological treatment with a variety of modalities including mood stabilizers, antidepressants, and benzodiazepines, as well as antipsychotics as necessary. The rates of switching into brief to full hypomania or mania during the use of antidepressants is described, and new data suggesting the potential utility of continuing antidepressants in the small group of patients showing an initial acute and persistent response is noted. Read More

    Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs.
    Bipolar Disord 2002 ;4 Suppl 1:15-20
    Stanley Foundation Research Center, Ministry of Health Mental Health Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Guron University of the Negev, Beersheva Israel.
    Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium. valproate and inositol targets may be combined readily. It has been shown that lithium inhibits yeast inositol monophosphatase (encoded by INM1 and INM2), and both valproate and lithium reduce intracellular inositol. Read More

    Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression.
    Bipolar Disord 2002 Feb;4(1):17-33
    Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buch, and Department of Neurology, Charité University Hospital, Humboldt University Berlin, Berlin, Germany.
    Major depression, whose biological origins have been difficult to grasp for decades, might result from a disturbance in neuronal plasticity. New theories begin to consider a fundamental role of adult hippocampal neurogenesis in this loss of plasticity. Could depression and other mood disorders therefore be 'stem cell disorders'? In this review, the potential role of adult hippocampal neurogenesis and of neuronal stem or progenitor cells in depression is discussed with regard to those aspects that are brought up by recent research on how adult hippocampal neurogenesis is regulated. Read More

    Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review.
    Bipolar Disord 2000 Dec;2(4):305-15
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892-1272, USA.
    Recent evidence suggests that lithium therapy (even as supplemented by antidepressants and neuroleptics) is inadequate for the majority of patients with bipolar illness, and particularly those with rapid cycling. Valproate and carbamazepine have emerged as adjuncts and alternatives, but they, too, often require additional approaches with lithium, thyroid hormones, and other putative mood stabilizers, including nimodipine (and related dihydropyridine calcium channel blockers), lamotrigine, gabapentin, topiramate, and the atypical neuroleptics. Evaluating how these agents and the unimodal antidepressants are optimally applied and sequenced in the treatment of bipolar illness with its multiple subtypes, patterns and comorbidities will require much future investigation and the development of new methodological clinical trial approaches. Read More

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