4,308,210 results match your criteria Clinical Approaches in Bipolar Disorders [Journal]


Point of Care Echocardiography in an Irish Critical Care Unit

Ir Med J 2018 09 10;111(8):800. Epub 2018 Sep 10.

Consultant Intensivist, Mater Misercordiae University Hospital, Eccles Street, Dublin 7, Ireland

Aims We sought to evaluate the clinical impact of a 6 month transthoracic echocardiography (TTE) teaching programme in a critical care unit. Methods An observational single centre study. Four critical care doctors, 2 fellows and 2 consultants were trained to use TTE. Read More

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September 2018
1 Read

Antimicrobial activity of ceftolozane-tazobactam against multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa clinical isolates from a Spanish hospital.

Rev Esp Quimioter 2018 Dec 14. Epub 2018 Dec 14.

Ana Isabel López-Calleja, Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón. 3ª planta Edificio de Consultas Externas - c/ Padre Arrupe s/n, 50009 Zaragoza, Spain.

Objective: Our objective was to evaluate the in vitro activity of ceftolozane-tazobactam against multidrug resistant (MDR) and extensively drug-resistant (XDR) non metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates at Hospital Universitario Miguel Servet (Zaragoza, Spain) from February 2016 to October 2017.

Methods: We evaluated the in vitro activity of ceftolozane-tazobactam and other antipseudomonal antibiotics against 12 MDR and 117 XDR non metallo-β-lactamase producing P. aeruginosa isolates. Read More

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December 2018

[Evolution of the incidence of colonized and infected patients by VIM carbapenemase-producing bacteria in a pediatric hospital in Spain].

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Raquel González Rubio, Escuela Nacional de Sanidad. C/Sinesio Delgado 10, 28029 Madrid. Spain.

Objective: The aim of this study is to describe the evolution of the incidence of infected and colonized patients with carbapenemase VIM-producing bacteria (CPB-VIM) at a national referral pediatric center in Madrid, Spain, between 2012 and 2015.

Methods: Descriptive epidemiological surveillance study. The surveillance system included case detection (screening for BPC colonization in all admitted patients, with periodicity according to the ward) and control measures (contact precautions, identification of previously colonized patients at admission, environmental cleaning, education, supervision of contact precautions, and patient cohort). Read More

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December 2018

Strategies for the management of invasive fungal infections due to filamentous fungi in high-risk hemato-oncological patients.

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Carlos Vallejo, Hospital Donostia, Begiristain Doktorea Pasealekua, 109, 20014 Donostia, Gipuzkoa, Spain.

Objective: In recent years, the introduction of new antifungals for the prevention of invasive fungal infections (IFIs) in hemato- oncological patients, particularly extended-spectrum azoles, has led to a change in the diagnostic and therapeutic strategies for established or suspected breakthrough IFI. The aim of the study was to identify the diagnostic and therapeutic strategies used in the management of IFIs in hemato-oncological patients in Spain, and to assess compliance with the recommendations of the consensus documents and clinical practice guidelines.

Methods: An online, anonymous, cross-sectional survey was conducted between January and September 2016 involving 137 specialists from third-level hospitals in Spain with Departments of Hematology that regularly deal with IFIs. Read More

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December 2018

Cognitive training benefit depends on brain injury location in adolescents with traumatic brain injury: a pilot study.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.

Background: Executive dysfunctioning after pediatric traumatic brain injury (TBI) has been linked to poor outcomes in school performance, social functioning and employment. The credibility of training-induced cognitive enhancement in TBI is threatened by its limited proof of benefit in executive skills of daily living.

Aim: Our primary aim was to investigate if cognitive intervention for improving impairments in executive functions in the chronic stage of traumatic brain injury is effective during adolescence. Read More

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December 2018

A 9-months multidisciplinary rehabilitation protocol based on early post-operative mobilization following a chronic-degenerative patellar tendon rupture in a professional soccer player: a case report.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Isolated patellar tendon rupture (PTR) is the final stage of a long-standing tendon chronic degeneration. PTR requires immediate repair in order to avoid important muscle retraction and tendon fibrosis. The aim was to describe the effects of a rehabilitation protocol after chronic-degenerative PTR on subjective functional outcomes, knee range of motion (ROM), size, and strength in a professional football player. Read More

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December 2018

Integrating Biological Networks for Drug Target Prediction and Prioritization.

Methods Mol Biol 2019 ;1903:203-218

Computational Biology, GSK R&D, Collegeville, PA, USA.

Computational prediction of the clinical success or failure of a potential drug target for therapeutic use is a challenging problem. Novel network propagation algorithms that integrate heterogeneous biological networks are proving useful for drug target identification and prioritization. These approaches typically utilize a network describing relationships between targets, a method to disseminate the relevant information through the network, and a method to elucidate new associations between targets and diseases. Read More

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January 2019

Network-Based Drug Repositioning: Approaches, Resources, and Research Directions.

Methods Mol Biol 2019 ;1903:97-113

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

The wealth of knowledge and omic data available in drug research allowed the rising of several computational methods in drug discovery field yielding a novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning. Read More

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January 2019

Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov.

Authors:
Eric Wen Su

Methods Mol Biol 2019 ;1903:61-72

Advanced Analytics Hub, Eli Lilly and Company, Indianapolis, IN, USA.

The protocol below describes an in silico method for drug repositioning (drug repurposing). The data source is ClinicalTrials.gov , which contains about a quarter of a million clinical studies. Read More

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January 2019

Performing an In Silico Repurposing of Existing Drugs by Combining Virtual Screening and Molecular Dynamics Simulation.

Methods Mol Biol 2019 ;1903:23-43

Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran.

Drug repurposing has become one of the most widely used methods that can make drug discovery more efficient and less expensive. Additionally, computational methods such as structure-based drug designing can be utilized to make drug discovery more efficient and more accurate. Now imagine what can be achieved by combining drug repurposing and computational methods together in drug discovery, "in silico repurposing. Read More

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January 2019

Pediatric Thrombotic Events: Incidence, Clinical Risk Factors and Outcome.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.

Objective: To study the incidence, clinical risk factors and outcome of thrombotic events in pediatric age group of 1 mo-12 y.

Methods: This prospective observational study was conducted in a tertiary care institute from September 2015 through October 2017. Forty nine children with thrombosis from 1 mo-12 y were enrolled. Read More

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December 2018
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Efficacy of Telephone Follow-Up in Children Tonsillectomy with Day Surgery.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of ENT, Affiliated Renhe Hospital of China, Three Gorges University, Second Clinical Medical College of China, No. 410 Yiling Road, Yi Chang, Hubei, China.

Objective: Day surgery for tonsillectomy has become more and more popular in China. However, many parents face difficulties to cope up with the pain and side effects after surgery. The present study was aimed to examine the efficacy of telephone follow-up on children's post-discharge recovery after tonsillectomy. Read More

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December 2018

Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population.

Int J Hematol 2018 Dec 13. Epub 2018 Dec 13.

Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan.

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare form of cytotoxic T-cell lymphoma. It is believed that SPTL in patients without hemophagocytic syndrome (HPS) follows an indolent course; in contrast, SPTL in patients with HPS has been associated with unfavorable survival. To provide more clinical data on SPTL in Asian populations and to identify optimal therapeutic strategies for SPTL, we assessed the clinicopathological features and long-term follow-up data of 10 Taiwanese SPTL patients diagnosed at a single center. Read More

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December 2018

Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling.

J Mol Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Widespread inflammatory lesions within the central nervous system grey and white matter are major hallmarks of multiple sclerosis. The development of full-blown demyelinating multiple sclerosis lesions might be preceded by preactive lesions which are characterized by focal microglia activation in close spatial relation to apoptotic oligodendrocytes. In this study, we investigated the expression of signaling molecules of oligodendrocytes that might be involved in initial microglia activation during preactive lesion formation. Read More

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December 2018

Prevalence and cardiac phenotype of patients with a phospholamban mutation.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Pathogenic mutations in the phospholamban (PLN) gene may give rise to inherited cardiomyopathies due to its role in calcium homeostasis. Several PLN mutations have been identified, with the R14del mutation being the most prevalent cardiomyopathy-related mutation in the Netherlands. It is present in patients diagnosed with arrhythmogenic cardiomyopathy as well as dilated cardiomyopathy. Read More

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December 2018

Differences at surgery between patients with bicuspid and tricuspid aortic valves.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, Amsterdam University Medical Centre, location AMC, Amsterdam, The Netherlands.

Aim: To determine differences in surgical procedures and clinical characteristics at the time of surgery between native bicuspid aortic valves (BAV) and tricuspid aortic valves (TAV) in patients being followed up after aortic valve surgery (AVS).

Methods: In this retrospective cohort study in a non-academic hospital, we identified patients who had a surgeon's report of the number of native valve cusps and were still being followed up. We selected patients with BAV and TAV, and used multivariable regression analyses to identify associations between BAV-TAV and pre-specified clinical characteristics. Read More

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December 2018

Use, timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice: insights from a 'real world' prospective registry.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Isala Heart Centre, Zwolle, The Netherlands.

Background: An early invasive strategy (EIS) is recommended in high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), defined as coronary angiography (CAG), within 24 h of admission. The aim of the present study is to investigate guideline adherence, patient characteristics associated with timing of the intervention and clinical outcome.

Methods: In a prospective registry, the use and timing of CAG and the characteristics and clinical outcome associated with timing were evaluated in high-risk ACS patients. Read More

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December 2018

Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative.

Ann Biomed Eng 2018 Dec 13. Epub 2018 Dec 13.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective of this study was to develop a template-based modeling method for rapid prediction of knee joint cartilage degeneration. Read More

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December 2018
3 Reads

The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Probiotics Antimicrob Proteins 2018 Dec 13. Epub 2018 Dec 13.

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

We searched bibliographic databases from inception through May 2018 to evaluate the effect of probiotics (or synbiotics) supplementation in women suffering from polycystic ovary syndrome (PCOS). Seven trials involving 236 women with PCOS and 235 controls were included in the meta-analysis. Comparing with the control group, probiotics (or synbiotics) may improve Quantitative insulin sensitivity check index (QUICKI) (standardized mean difference (SMD) 0. Read More

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December 2018

Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.

Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More

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December 2018

High Dose Prednisolone Lowers Plasma Glycated Albumin Levels Compared to Actual Glycemic Control: A Retrospective Observational Study.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.

Introduction: Glycated hemoglobin (A1c) and glycated albumin (GA) are often used as indicators of glycemic control. In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.

Methods: We investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs). Read More

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December 2018
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The content validity of the ANMS GCSI-DD in patients with idiopathic or diabetic gastroparesis.

J Patient Rep Outcomes 2018 Dec 13;2(1):61. Epub 2018 Dec 13.

Temple University Hospital, 3401 N Broad Street, #1003, Philadelphia, PA, 19140, USA.

Background: The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index-Daily Diary (ANMS GCSI-DD) was developed to meet Food and Drug Administration (FDA) recommendations for patient-reported outcome (PRO) endpoints in gastroparesis studies, including therapeutic trials. The current version of the ANMS GCSI-DD contains five items pertaining to nausea, early satiety, post-prandial fullness, upper abdominal pain, and vomiting. The specific aims of this study were to determine if the appropriate symptoms are included in the ANMS GCSI-DD and to assess the content validity in patients with idiopathic (IG) and diabetic gastroparesis (DG). Read More

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December 2018

Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals.

Paediatr Drugs 2018 Dec 13. Epub 2018 Dec 13.

Division of Rheumatology, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Background: Arthropathy of Down syndrome (DA) is largely under-recognized, with an average 2-year delay in diagnosis. Most patients present with polyarthritis, and treatment has historically been challenging.

Objectives: Our objective was to investigate the clinical features and treatment of DA in the largest cohort reported to date. Read More

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December 2018

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
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Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review.

Mycopathologia 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. Read More

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December 2018

Eotaxins and C-C chemokine receptor type 3 in Parkinson's disease.

Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.

Geriatric Care Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran.

Parkinson's disease (PD) is one of the most common neuroinflammatory disorders and inflammatory processes seem to play an important role in the pathogenesis of PD. Chemokines as inflammatory mediators, which are involved in the recruitment of leukocytes, can play a role in the pathogenesis of PD. The aim of this study was to examine the serum level of eotaxins (CCL11, CCL24, and CCL26) and the expression of C-C chemokine receptor type 3 (CCR3) in patients with PD compared with healthy subjects. Read More

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December 2018

Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome.

Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.

Physical Medicine and Rehabilitation Clinic, Bingöl State Hospital, Bingöl, Turkey.

Objective: A high prevalence of obesity in fibromyalgia syndrome (FMS) predisposes patients to metabolic changes. It is not clear how the clinical manifestations of the disease affect metabolism. This study aimed to investigate leptin, growth hormone (GH), and insulin-like growth factor (IGF-1) levels in FMS, and their relationship with body mass index (BMI) and disease severity. Read More

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December 2018

Nerve grafting for peripheral nerve injuries with extended defect sizes.

Wien Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Artificial and non-artificial nerve grafts are the gold standard in peripheral nerve reconstruction in cases with extensive loss of nerve tissue, particularly where a direct end-to-end suture or an autologous nerve graft is inauspicious. Different materials are marketed and approved by the US Food and Drug Administration (FDA) for peripheral nerve graft reconstruction. The most frequently used materials are collagen and poly(DL-lactide-ε-caprolactone). Read More

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December 2018

Correction to: Weight Reduction and Pioglitazone are Cost-Effective for the Treatment of Non-alcoholic Fatty Liver Disease in Thailand.

Pharmacoeconomics 2018 Dec 13. Epub 2018 Dec 13.

Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, 65000, Phitsanulok, Thailand.

Weight Reduction is Cost-Effective for the Treatment of Non-alcoholic Fatty Liver Disease in Thailand. Read More

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December 2018

Pembrolizumab for Locally Advanced or Metastatic Urothelial Cancer Where Cisplatin is Unsuitable: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Pharmacoeconomics 2018 Dec 13. Epub 2018 Dec 13.

University College London Hospitals NHS Foundation Trust, London, UK.

As part of its Single Technology Appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer (Merck Sharp & Dohme) of pembrolizumab (Keytruda) to submit evidence of its clinical and cost effectiveness for the treatment of locally advanced or metastatic urothelial cancer where cisplatin is unsuitable. The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a detailed review of the evidence for the clinical and cost effectiveness of the technology, based on the company's submission (CS) to NICE. Read More

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December 2018

Obinutuzumab in Combination with Chemotherapy for the First-Line Treatment of Patients with Advanced Follicular Lymphoma : An Evidence Review Group Evaluation of the NICE Single Technology Appraisal.

Pharmacoeconomics 2018 Dec 13. Epub 2018 Dec 13.

Institute of Health Policy and Management/Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands.

The National Institute for Health and Care Excellence (NICE), as part of the institute's single technology appraisal (STA) process, invited the company that makes obinutuzumab (Roche Products Limited) to submit evidence of the clinical and cost effectiveness of the drug in combination with chemotherapy, with or without obinutuzumab as maintenance therapy for adult patients with untreated, advanced follicular lymphoma (FL) in the UK. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG). This paper describes the company's submission, the ERG review, and NICE's subsequent decisions. Read More

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December 2018

Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice.

Neurochem Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, Tianjin, 300121, China.

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Read More

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December 2018

Single-center experience using the 3MAX or 4MAX reperfusion catheter for the treatment of acute ischemic stroke with distal arterial occlusions in patients not eligible for intravenous fibrinolysis.

Radiol Med 2018 Dec 13. Epub 2018 Dec 13.

Unit of Neuroimaging and Neurointervention (NINT), Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte", Viale M. Bracci 2, Siena, Italy.

Background: In acute stroke, distal cerebrovascular occlusions can be linked to severe clinical symptoms, and treatment by mechanical thrombectomy may have an important clinical impact. When intravenous fibrinolytic therapy is firmly contraindicated, it remains the only treatment option.

Methods: A total of 42 patients with isolated distal arterial occlusions and absolute contraindication for intravenous fibrinolytic therapy were retrospectively included. Read More

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December 2018

Functional significance of channelopathy gene variants in unexplained death.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Pediatrics, NYU School of Medicine, 450 E 29th Street, ACLS 824, New York, NY, 10016, USA.

Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual. Read More

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December 2018
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Insomnia and cardiorespiratory fitness in a middle-aged population: the SCAPIS pilot study.

Sleep Breath 2018 Dec 13. Epub 2018 Dec 13.

Center for Sleep and Vigilance Disorders, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8b, Box 421, SE-40530, Gothenburg, Sweden.

Background: The relationship between insomnia and cardiorespiratory fitness (CRF), a well-established risk factor for cardiovascular disease, has not been extensively studied. We aimed to assess the independent association between insomnia and CRF in a population-based cohort of subjects aged 50 to 64 years.

Methods: Subjects participating in the Swedish CArdioPulmonary bioImaging Study (SCAPIS) pilot cohort (n = 603, men 47. Read More

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December 2018

A review of filamin A mutations and associated interstitial lung disease.

Eur J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Clinical Genetics Department, Our Lady's Children's Hospital, Dublin, Ireland.

The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. Read More

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December 2018

The bacteriology in adult patients with pneumonia and parapneumonic effusions: increased yield with DNA sequencing method.

Eur J Clin Microbiol Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Solna, Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

The aim of this study was to use a 16S rDNA sequencing method in combination with conventional culture in patients with parapneumonic effusions (PPE) to evaluate the methods, study the microbiological spectrum, and examine the presence of bacteria within the different stages of PPE. Adults with community-acquired pneumonia (CAP) and PPE (n = 197) admitted to the Departments of Infectious Diseases at four hospitals in Stockholm County during 2011-2014 were prospectively studied. All patients underwent thoracentesis. Read More

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December 2018

Depression, ART Adherence, and Receipt of Case Management Services by Adults with HIV in North Carolina, Medical Monitoring Project, 2009-2013.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

North Carolina Department of Health and Human Services, Division of Public Health, Communicable Disease Branch, Raleigh, NC, 27603, USA.

Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009-2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with "probable current depression" and with 100% ART dose adherence. Read More

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December 2018

Health Care Facility Characteristics are Associated with Variation in Human Immunodeficiency Virus Pre-exposure Prophylaxis Initiation in Veteran's Health Administration.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

VA Puget Sound Health Care System, Health Services Research and Development, Seattle, WA, USA.

To quantify health care facility-level variation in pre-exposure prophylaxis (PrEP) use in the Veteran's Health Administration (VHA); to identify facility characteristics associated with PrEP use. Retrospective analysis of the health care facility-level rate of PrEP initiation in VHA through June 30, 2017. Standardized PrEP initiation rates were used to rank facilities. Read More

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December 2018

Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes.

Ann Surg Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes.

Methods: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and ≥ 14 weeks). Read More

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December 2018

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

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December 2018

The availability of drug by liposomal drug delivery : Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate.

Invest New Drugs 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Pharmacy, Division of Laboratory Medicine & Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands.

Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the underlying pharmacokinetics of the targeted drug delivery by liposomes, individual encapsulated and non-encapsulated drug concentrations in blood, tumor, liver, spleen and kidneys were quantified after i.v. Read More

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December 2018

ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

Neurocrit Care 2018 Dec 13. Epub 2018 Dec 13.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background/purpose: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH).

Methods: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Read More

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December 2018
1 Read

Vitreoretinal disease diagnosis, management, and clinical pearls by Ingrid U. Scott, Carl D. Regillo, Harry W. Flynn, Jr., Gary C. Brown (2017) pp. 640, Hardback ISBN: 9781626231337 Thieme Publishers.

Authors:
Carsten Meyer

Graefes Arch Clin Exp Ophthalmol 2018 Aug 16;256(8):1561. Epub 2018 Jun 16.

Department of Ophthalmology, Pallas Kliniken, Bahnhofplatz 4, 5000, Aarau, Switzerland.

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Undiagnosed cardiac deficits in non-small cell carcinoma patients in the candidate population for anti-cachexia clinical trials.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. Read More

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December 2018

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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December 2018
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