4,415,985 results match your criteria Clinical & Surgical Journal of Ophthalmology CSJO [Journal]


What Interpersonal Problems Are Related to Different Therapeutic Techniques Early in Treatment?

Clin Psychol Psychother 2019 Apr 24. Epub 2019 Apr 24.

Derner School of Psychology, Adelphi University.

The current study seeks to explore the relationship between patient-reported interpersonal problems and therapist interventions in early psychodynamic psychotherapy for 71 outpatients. Pre-treatment ratings on the Inventory of Interpersonal Problems (IIP-C; Horowitz, Alden, Wiggins, & Pincus, 2000) total and subscale scores were examined in relation to early treatment process. Independent clinicians reliably rated therapist use of Psychodynamic-Interpersonal (PI) and Cognitive-Behavioral (CB) interventions using the CPPS (Hilsenroth, Blagys, Ackerman, Bonge, & Blais, 2005) over two early treatment sessions (3 & 9 ). Read More

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http://dx.doi.org/10.1002/cpp.2370DOI Listing

PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

NK and T cell subsets in malignant mesothelioma patients: baseline pattern and changes in the context of anti-CTLA-4 therapy.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK cell subsets and their recognition of mesothelioma cells remains to be explored. We used RNA expression data of MM biopsies derived from the cancer genome atlas to evaluate the immune cell infiltrates. Read More

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http://dx.doi.org/10.1002/ijc.32363DOI Listing

Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
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Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

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http://dx.doi.org/10.1002/ijc.32361DOI Listing

Composer-Visual Cohort Analysis of Patient Outcomes.

Appl Clin Inform 2019 Mar 24;10(2):278-285. Epub 2019 Apr 24.

Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States.

Objective:  Visual cohort analysis utilizing electronic health record data has become an important tool in clinical assessment of patient outcomes. In this article, we introduce Composer, a visual analysis tool for orthopedic surgeons to compare changes in physical functions of a patient cohort following various spinal procedures. The goal of our project is to help researchers analyze outcomes of procedures and facilitate informed decision-making about treatment options between patient and clinician. Read More

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http://dx.doi.org/10.1055/s-0039-1687862DOI Listing

Quality Informatics: The Convergence of Healthcare Data, Analytics, and Clinical Excellence.

Appl Clin Inform 2019 Mar 24;10(2):272-277. Epub 2019 Apr 24.

Warren Alpert Medical School and Center for Biomedical Informatics, Brown University, Rhode Island, United States.

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http://dx.doi.org/10.1055/s-0039-1685221DOI Listing

Long-term Outcomes of Microvascular Decompression in the Treatment of Hemifacial Spasm Based on Different Offending Vessels.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, China.

Objective:  To evaluate clinical features, outcomes, and complications in patients with hemifacial spasm (HFS) after microvascular decompression (MVD) of different offending vessels.

Methods:  Clinical data were collected from 362 patients with HFS treated with MVD between January 2013 and January 2014. Patients were divided into five groups based on the offending vessel: A (anterior inferior cerebellar artery [AICA] compression), B (posterior inferior cerebellar artery [PICA] compression), C (AICA plus PICA compression), D (vertebral artery [VA] compression), and E (VA plus small vessel compression). Read More

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http://dx.doi.org/10.1055/s-0039-1685199DOI Listing

Using Artificial Intelligence to Identify Factors Associated with Autism Spectrum Disorder in Adolescents with Cerebral Palsy.

Neuropediatrics 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatric Orthopaedic Surgery, Lenval University Pediatric Hospital of Nice, Nice, France.

Autism spectrum disorder (ASD) is common in adolescents with cerebral palsy (CP) and there is a lack of studies applying artificial intelligence to investigate this field and this population in particular. The aim of this study is to develop and test a predictive learning model to identify factors associated with ASD in adolescents with CP. This was a multicenter controlled cohort study of 102 adolescents with CP (61 males, 41 females; mean age ± SD [standard deviation] = 16. Read More

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http://dx.doi.org/10.1055/s-0039-1685525DOI Listing

Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

Thromb Haemost 2019 Apr 24. Epub 2019 Apr 24.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. Read More

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http://dx.doi.org/10.1055/s-0039-1685453DOI Listing

Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.

Skin Pharmacol Physiol 2019 Apr 24;32(3):162-172. Epub 2019 Apr 24.

Institute for Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Background: The number of patients who has a daily intake of antihypertensive drugs is rising, due to an also rising prevalence of lifestyle diseases. Interestingly, knowledge about effects of these drugs in terms of wound healing is low.

Objective: Based on a few differing studies, the idea arose that antihypertensives may have side effects on wound healing. Read More

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http://dx.doi.org/10.1159/000499433DOI Listing
April 2019
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Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

Respiration 2019 Apr 24:1-11. Epub 2019 Apr 24.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

Background: Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support.

Objectives: The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Read More

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http://dx.doi.org/10.1159/000498972DOI Listing

Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review.

Oncology 2019 Apr 24:1-17. Epub 2019 Apr 24.

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

Background: Carcinoid syndrome symptoms significantly reduce quality of life in patients with neuroendocrine tumors. Evidence supporting the use of somatostatin analogues in carcinoid syndrome symptom control dates back 30 years. The introduction of new treatment options for carcinoid syndrome, such as telotristat ethyl in 2017, highlights the need for a review of high-level evidence of new and established systemic treatments. Read More

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http://dx.doi.org/10.1159/000499049DOI Listing

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.

Ophthalmic Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. Read More

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http://dx.doi.org/10.1159/000499020DOI Listing

Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes.

Horm Res Paediatr 2019 Apr 24:1-11. Epub 2019 Apr 24.

Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: The systemic form of pseudohypoaldosteronism type 1 (PHA1) is an autosomal recessive disorder characterized by defective sodium transport in multi-organ systems. Mutations in the genes encoding the amiloride-sensitive epithelial sodium channel, ENaC, account for genetic causes of systemic PHA1. We describe systemic PHA1 due to 4 novel variants detected in SCNN1A and SCNN1B in 3 cases from 3 unrelated consanguineous families. Read More

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http://dx.doi.org/10.1159/000498860DOI Listing

Implementing Accessibility Settings in Touchscreen Apps for People Living with Dementia.

Gerontology 2019 Apr 24:1-11. Epub 2019 Apr 24.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

Background: Accessibility options within apps can enable customisation and improve usability. The consideration of accessibility for people living with dementia has not been explored but is necessary to prevent a "digital divide" in our society. This study set out to examine whether the introduction of accessibility settings for people with dementia in two mainstream gaming apps (Solitaire and Bubble Explode) could improve the user experience. Read More

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http://dx.doi.org/10.1159/000498885DOI Listing

First clinical retrospective investigation of limited projection CBCT for lung tumor localization in patients receiving SBRT treatment.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiation Oncology, Duke University Medical Center, PO Box 3295, Durham, NC 27710-3295, USA, Durham, North Carolina, UNITED STATES.

Purpose: To clinically investigate the limited-projection CBCT (LP-CBCT) technology for daily positioning of patients receiving breath-hold lung SBRT radiation treatment and to investigate the feasibility of reconstructing fast 4D-CBCT from 1 min 3D-CBCT scan.
 Method: Eleven patients who underwent breath-hold lung SBRT radiation treatment were scanned daily with on-board full-projection CBCT (CBCT) using half-fan scan. A subset of the CBCT projections and the prior planning CT were used to estimate the LP-CBCT images using the weighted free-form deformation method. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c0cDOI Listing

Miniature electroparticle-cuff for wireless peripheral neuromodulation.

J Neural Eng 2019 Apr 24. Epub 2019 Apr 24.

Bioengineering, University of Texas at Dallas Erik Jonsson School of Engineering and Computer Science, 800 W. Campbell Rd., BSB 13.637, Richardson, Texas, 75080-3021, UNITED STATES.

Recent developments in peripheral nerve electrodes allow the efficient and selective neuromodulation of somatic and autonomic nerves, which has proven beneficial in specific bioelectronic medical applications. However, current most clinical devices are wired and powered by implantable batteries which suffer from several limitations. We recently developed a sub-millimeter inductively powered neural stimulator (electroparticle; EP), and in this study, we report the integration of the EP onto commercial cuff electrodes (EP-C) allowing the wireless activation of peripheral nerves. Read More

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http://dx.doi.org/10.1088/1741-2552/ab1c36DOI Listing

Lobectomy in patients with differentiated thyroid cancer: indications and follow-up.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

J Yoon, Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea (the Republic of).

The extent of thyroid surgery for patients with low- and intermediate-risk differentiated thyroid carcinoma (DTC), with a primary tumour <4 cm and no extrathyroidal extension (ETE) or lymph node (LN) metastases, has shifted in a more conservative direction. However, clinicopathological risk factors, including microscopic ETE, aggressive histology, vascular invasion in papillary thyroid carcinoma (PTC), and intermediate volume of LN metastases, can only be identified after completing thyroid lobectomy. It is controversial whether patients with these risk factors should immediately undergo complete thyroidectomy and/or radioactive iodine remnant ablation, or should be monitored without further treatments. Read More

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http://dx.doi.org/10.1530/ERC-19-0085DOI Listing

Glucocorticoids and programming of the microenvironment in heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

L Zhang, Basic Sciences, Loma Linda University School of Medicine, Loma Linda, United States.

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily through interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. Read More

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http://dx.doi.org/10.1530/JOE-18-0672DOI Listing

A Comparison of Oral Hygiene Products and Professional Care: A six-week randomized clinical trial.

J Dent Hyg 2018 Oct;92(5):45-51

To investigate the anti-gingivitis efficacy of a novel oral hygiene routine consisting of a two-step stannous fluoride dentifrice and hydrogen peroxide whitening gel system, an interactive oscillating-rotating electric toothbrush, and expanded polytetrafluoroethylene floss. A total of 52 participants (n=52;mean age 35.8±11. Read More

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October 2018

Hospitalization Burden of Biliary Strictures and Cholangitis After Pancreaticoduodenectomy.

J Surg Res 2019 Apr 21;241:95-102. Epub 2019 Apr 21.

Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Postsurgical biliary disease in Roux-en-y and cholecystectomies has been investigated, but less literature exists regarding biliary complications after Whipple procedure (pancreaticoduodenectomy [PD]). Moreover, the hospital burden incurred after this complication has not been previously examined. The aim of this study is to assess the trends in hospitalization for biliary strictures and cholangitis after PD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193017
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http://dx.doi.org/10.1016/j.jss.2019.03.057DOI Listing
April 2019
4 Reads

IGF-1 reverses the osteogenic inhibitory effect of dexamethasone on BMP9-induced osteogenic differentiation in mouse embryonic fibroblasts via PI3K/AKT/COX-2 pathway.

J Steroid Biochem Mol Biol 2019 Apr 21. Epub 2019 Apr 21.

Department of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Yuzhong District, Chongqing 400010, PR China. Electronic address:

Glucocorticoid-Induced Osteoporosis (GIOP) is a prevalent clinical complication caused by large dose administration of glucocorticoids, such as Dexamethasone (Dex) and Prednisone. GIOP may lead to fractures and even Osteonecrosis of the Femoral Head (ONFH). It has been reported that glucocorticoids inhibit osteogenesis via the suppression of osteogenic differentiation in Mesenchymal Stem Cells (MSCs), but the precise mechanism underlying this suppression awaits further investigation. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.012DOI Listing

Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools.

Anaesth Crit Care Pain Med 2019 Apr 21. Epub 2019 Apr 21.

Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

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http://dx.doi.org/10.1016/j.accpm.2019.04.009DOI Listing

Anti-CGRP and anti-CGRP receptor monoclonal antibodies as antimigraine agents. Potential differences in safety profile postulated on a pathophysiological basis.

Peptides 2019 Apr 21. Epub 2019 Apr 21.

Institute of Pharmacology. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma -Università Cattolica del Sacro Cuore, Largo F. Vito, 1, 00168, Rome, Italy. Electronic address:

Calcitonin gene-related peptide (CGRP), is a peptide neurotransmitter with potent vasodilating properties. CGRP is believed to play a primary role in the pathogenesis of migraine. As such, CGRP and its receptors are obvious druggable targets for novel anti-migraine agents. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.012DOI Listing

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Free Radic Biol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemistry, University of Patras, Rion 26504, Greece. Electronic address:

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially created using (i) a monothiol mouse Trx2 species for capturing protein partners from different organs and (ii) yeast two hybrid screens on human liver and rat brain cDNA libraries. The resulting interactome consisted of 195 proteins (Trx2 included) plus the mitochondrial 16S RNA. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.018DOI Listing

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.

Cell Rep 2019 Apr;27(4):1265-1276.e4

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from BTCs were cultured stably for >1 year and closely recapitulated the histopathology, gene expression, and genetic alterations evident in the primary tumors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.088DOI Listing

Corneal autophagy and ocular surface inflammation: A new perspective in dry eye.

Exp Eye Res 2019 Apr 21. Epub 2019 Apr 21.

Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, 515282, PR China. Electronic address:

Dry eye disease (DED), a multifactorial ocular surface disorder affecting millions of individuals worldwide, is characterized by inflammation and damage to the ocular surface. It is unclear whether corneal autophagy participates in ocular surface inflammation observed in DED. To test this involvement, dry eye (DE) was induced in female C57BL/6 mice housed in a controlled environment by subcutaneous injection of scopolamine. Read More

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http://dx.doi.org/10.1016/j.exer.2019.04.023DOI Listing

Molecular aspects of signalling in diabesity.

Mol Aspects Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.04.003DOI Listing
April 2019
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New molecular approaches to Alzheimer's disease.

Clin Biochem 2019 Apr 21. Epub 2019 Apr 21.

Vita-Salute San Raffaele University, Milan, Italy; Unit of Genomics for Human Disease Diagnosis, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy; IRCCS San Raffaele Hospital, Clinical Molecular Biology Laboratory, Milan, Italy. Electronic address:

Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia. It affects mainly older people, accounting for 50-80% of dementia cases. The age is the main associated risk factor and based on the onset age, early-onset (EOAD) or late-onset (LOAD) forms are distinguished. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.010DOI Listing
April 2019
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Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

Expert Rev Mol Diagn 2019 Apr 24. Epub 2019 Apr 24.

b Aix Marseille University , CRCM, INSERM, CNRS, AP-HM, Multidisciplinary Oncology and Therapeutic Innovations Department , Chemin des Bourrely, 13015 , Marseille , France .

Introduction: Companion diagnostic tests (CDXs) are considered mandatory for decision making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1 immunohistochemistry tests, have been questioned and re-examined for use with new combination therapies that are being evaluated in clinical trials. Read More

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http://dx.doi.org/10.1080/14737159.2019.1611426DOI Listing

What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation.

Annu Rev Neurosci 2019 Apr 24. Epub 2019 Apr 24.

Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.

Deciding what to do and when to move is vital to our survival. Clinical and fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the basal ganglia, the striatum, receives inputs from frontal, sensory, and motor cortices and interconnected thalamic areas that provide information about potential goals, context, and actions and directly or indirectly modulates basal ganglia outputs. Read More

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http://dx.doi.org/10.1146/annurev-neuro-072116-031033DOI Listing

Formulation and characterization of conjugate vaccines to reduce opioid use disorders suitable for pharmaceutical manufacturing and clinical evaluation.

Mol Pharm 2019 Apr 24. Epub 2019 Apr 24.

This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology transfer, Good Manufacturing Process (GMP), and clinical evaluation. Lead vaccines used the highly immunogenic carrier protein keyhole limpet hemocyanin (KLH), which poses formulation problems because of its size. To address this barrier to translation, an oxycodone-based hapten conjugated to GMP-grade subunit KLH (OXY-sKLH) and adsorbed on alum adjuvant was studied with regard to carbodiimide coupling reaction time, buffer composition, purification methods for conjugates, conjugate size, state of aggregation, and protein:alum ratio. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01296DOI Listing

Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.

N Engl J Med 2019 04;380(17):1628-1637

From the University of Texas M.D. Anderson Cancer Center, Houston (N.P., M.D., H.M.K., M.K.); Dana-Farber Cancer Institute (A.A.L.) and Boston University School of Medicine (J.M.S.), Boston, and Veristat, Southborough (J.B.) - all in Massachusetts; H. Lee Moffitt Cancer Center, Tampa, FL (K.L.S., J.E.L.); City of Hope National Medical Center, Duarte, CA (A.S.S.); Ohio State University, Columbus (S.V.); Winship Cancer Institute of Emory University, Atlanta (W.B.); Duke University Medical Center, Durham, NC (D.A.R.); and Roswell Park Comprehensive Cancer Center, Buffalo (E.S.W.), and Stemline Therapeutics, New York (S. Spence, S. Shemesh, C.L.B., I.B.) - both in New York.

Background: Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin-3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to truncated diphtheria toxin.

Methods: In this open-label, multicohort study, we assigned 47 patients with untreated or relapsed BPDCN to receive an intravenous infusion of tagraxofusp at a dose of 7 μg or 12 μg per kilogram of body weight on days 1 to 5 of each 21-day cycle. Read More

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http://dx.doi.org/10.1056/NEJMoa1815105DOI Listing

Bilateral Papillitis and Anterior Uveitis in a Pediatric Patient.

S D Med 2019 Mar;72(3):110-113

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

We report a case of bilateral papillitis and anterior uveitis in a pediatric patient with preceding viral prodrome. Because this is a rare disease in the pediatric population, work-up in this case was extensive given the wide differential of papilledema in the pediatric setting. The clinical significance of this case is to bring to light the timely recognition, follow-up, and treatment of this disease to minimize the burden to the patient and family. Read More

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Pericardial effusion with necrotic ventricular mass in a kidney transplant recipient.

Am J Transplant 2019 May;19(5):1589-1591

Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1111/ajt.15294DOI Listing

Melatonin Enhances Autophagy and Decreases Apoptosis Induced by nanosilica in RAW264.7 cells.

IUBMB Life 2019 Apr 24. Epub 2019 Apr 24.

Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Melatonin is one of the main hormones that regulate biological rhythms and have immunomodulation, anti-inflammatory, and antioxidation functions. In this study, we aimed to explore the effect of melatonin on the autophagy, apoptosis, and inflammatory reaction of macrophages (RAW264.7 cells) stimulated by nanosilica. Read More

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http://dx.doi.org/10.1002/iub.2055DOI Listing

miR-146a-5p Enhances Hepatitis B Virus Replication Through Autophagy to Promote Aggravation of Chronic Hepatitis B.

IUBMB Life 2019 Apr 24. Epub 2019 Apr 24.

Department of Infectious Diseases, Key Laboratory of Hunan Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan, China.

The objective of this study was to investigate the mechanism by which miR-146a-5p mediated autophagy and hepatitis B virus (HBV) replication. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the mRNA expression levels of miR-146a-5p and X-linked inhibitor of apoptosis (XIAP) and HBV DNA and RNA. The protein expression levels of XIAP, IκB-α, murine double minute 2 oncoprotein (MDM2) and p53, the phosphorylation of p65, and the conversion of light chain 3 (LC3)-I to LC3-II were detected by Western blotting. Read More

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http://dx.doi.org/10.1002/iub.2044DOI Listing

The diagnostic ability of high-fluorescent cells combined with carcinoembryonic antigen for malignant pleural effusion.

Int J Lab Hematol 2019 Apr 24. Epub 2019 Apr 24.

Department of Clinical Laboratory, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Introduction: High-fluorescent cells (HFCs) that are detected with an automated hematology analyzer may be useful for the detection of tumor cells; however, the diagnostic ability of HFCs for differentiating malignant pleural effusion is limited. The aim of this study was to investigate the diagnostic value of the combined detection of HFCs with the tumor marker carcinoembryonic antigen (CEA) for the identification of malignant hydrothorax.

Methods: A total of 115 pleural effusions were collected. Read More

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http://dx.doi.org/10.1111/ijlh.13034DOI Listing

A Clinical Guideline on Paget's Disease of bone-A Guideline or a Review?

Authors:
B L Langdahl

J Bone Miner Res 2019 Apr;34(4):577-578

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1002/jbmr.3709DOI Listing

Differential tissue expression of extracellular vesicle-derived proteins in prostate cancer.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.

Background: Proteomic profiling of extracellular vesicles (EVs) from prostate cancer (PCa) and normal prostate cell lines, led to the identification of new candidate PCa markers. These proteins included the nuclear exportin proteins XPO1 (also known as CRM1), the EV-associated PDCD6IP (also known as ALIX), and the previously published fatty acid synthase FASN. In this study, we investigated differences in expression of XPO1 and PDCD6IP on well-characterized prostate cancer cohorts using mass spectrometry and tissue microarray (TMA) immunohistochemistry to determine their diagnostic and prognostic value. Read More

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http://dx.doi.org/10.1002/pros.23813DOI Listing

Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses for Fall Prevention in Older Adults: A Randomized Controlled Trial.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Interdisciplinary Consortium on Advanced Motion Performance, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Objective: To examine the effects of bilateral custom-made ankle-foot orthoses (AFOs) to prevent falls for older adults with concern about or at risk for falling over 12-month daily use.

Design: Secondary analysis of a randomized controlled trial.

Setting: Community-dwelling older adults. Read More

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http://dx.doi.org/10.1111/jgs.15929DOI Listing

The Montreal Cognitive Assessment After Omission of Hearing-Dependent Subtests: Psychometrics and Clinical Recommendations.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Department of Psychology, Concordia University, Montréal, Quebec, Canada.

Objectives: Hearing loss (HL) is the third most common chronic health condition in older adults, yet it is often undiagnosed and/or untreated. Given the association between HL and cognitive impairment, it is expected that many people undergoing cognitive screening may have HL. The Montreal Cognitive Assessment (MoCA) is a brief screening test that assesses a wide range of cognitive functions sensitive to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Read More

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http://dx.doi.org/10.1111/jgs.15940DOI Listing

DSM-5 in patients seeking their first treatment for alcohol use disorder. Sex differences in the multicenter CohRTA study.

Adicciones 2019 Apr 8;0(0):1177. Epub 2019 Apr 8.

Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol - IGTP, Universitat Autònoma de Barcelona, Badalona.

Objective: We aimed to analyze sex differences in the DSM-5 criteria among patients admitted to  their first treatment of alcohol use disorder (AUD).

Methods: Assessment of AUD was carried out using DSM-5 diagnostic criteria in a multicenter study (CohRTA) within the Spanish Network on Addictive Disorders. Further, baseline questionnaires including socio-demographics, family history, lifetime alcohol consumption and other substance use, as well as clinical and laboratory parameters were obtained during admission. Read More

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http://dx.doi.org/10.20882/adicciones.1177DOI Listing

The relationship between motivations for cannabis consumption and problematic use.

Adicciones 2019 Apr 8;0(0):1221. Epub 2019 Apr 8.

Grup de Recerca en Addiccions Clínic (GRAC-GRE). Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS Hospital Clínic i Universitari de Barcelona. Universitat de Barcelona). Barcelona.

Introduction: Systematic screening of problematic cannabis use does not include the motivations that lead to consumption, although from a person-centered perspective this is fundamental. The present study explores the motivations for cannabis use in adults and its relationship with cannabis use patterns and problematic use.

Method: Adult cannabis users (previous 60 days) were recruited in the province of Barcelona (n = 468). Read More

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http://dx.doi.org/10.20882/adicciones.1221DOI Listing

Alcohol use and risk factors for self-harm behavior in Spanish adolescents.

Adicciones 2019 Mar 29;0(0):1239. Epub 2019 Mar 29.

Universidad de Oviedo.

Self-harm behaviors in children and adolescents constitute an important public health problem with prevalence figures in the clinical population between 40 and 80%. The objectives of the study were to analyze and compare the Spanish sub-samples of two studies, SEYLE and WE-STAY to determine prevalence, self-harm patterns and factors associated with self-harm behaviors, notably the use of alcohol or drugs. The questionnaires used in both studies were the Global School Health Survey (GSHS), the Beck Depression Inventory (BDI-II), the Strengths and Difficulties Questionnaire (SDQ). Read More

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http://dx.doi.org/10.20882/adicciones.1239DOI Listing

Underuse of Prophylactic Treatment Among Portuguese Patients with Primary Headache: A Retrospective Observational Study.

J Oral Facial Pain Headache 2019 Apr 24. Epub 2019 Apr 24.

Aims: To evaluate prescription of prophylactic treatment before and after consultation in a neurology headache clinic and to determine predictors for prophylactic treatment and clinical improvement.

Methods: Clinical records of consecutive patients assessed in a neurologic headache clinic in Portugal and diagnosed with acute or chronic migraine and/or tension-type headache were assessed. Prescription of prophylaxis before and after the first visit to the clinic were compared. Read More

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http://dx.doi.org/10.11607/ofph.2122DOI Listing
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