4,360,462 results match your criteria Clinical & Surgical Journal of Ophthalmology CSJO [Journal]


[Sclerosing polycystic adenosis of the parapharyngeal salivary gland: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):147-148

Department of Otorhinolaryngology Head and Neck Surgery, Second Clinical Medical of Army Medical University, Chongqing 400037, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.012DOI Listing
February 2019

[Experimental studies on the repair and restitution of cartilage by cartilage acellular extracellular matrix and adipose tissue-derived stem cells].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):133-138

Department of Ophthalmology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.

To investigate the effects of the repair and restitution of ear-shaped cartilage by adipose tissue-derived stem cells(ADSC) and cartilage acellular extracellular matrix. ADSC were extracted by digesting with collagenase type II from the adipose tissue from 32 patients with adiposity whose fats were drawn, and were cultured and subcultured in vitro. The natural biological scaffolds were prepared by acellular method using porcine ear cartilage, and then the second generation ADSC(5. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.007DOI Listing
February 2019

[Investigation of hearing loss and speech recognition ability of the elderly and analysis of its high risk factors].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):116-120

Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical Center, People's Liberation Army, Beijing 100042, China.

To investigate the hearing loss and speech disorders in the elderly, to analyze the risk factors of the elderly deafness, as well as to provide reference for the clinical research of the elderly deafness. From March 2016 to March 2018, 913 elderly people, who were tested for hearing and speech disorders, were examined by a unified questionnaire to investigate the demographic data of the subjects and the related factors of deafness, and the hearing and speech recognition tests were carried out. According to the hearing loss, the hearing impaired group was divided into the hearing impaired group (500, 1 000, 2 000 and 4 000 Hz, the average hearing threshold>25 dBHL) and the non hearing impaired group (the average hearing threshold of the four frequencies ≤25 dBHL), and then the single factor analysis and the unconditional regression analysis were used. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.004DOI Listing
February 2019

[Clinical diagnosis and surgical management of 110 cases of facial nerve schwannomas].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):101-109

Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

To elucidate the clinical behavior, causes of misdiagnosis, surgical management, and outcomes of facial nerve schwannomas (FNS). A retrospective review in Chinese People's Liberation Army General Hospital from January 1, 2002 to December 31, 2015 was carried out and evaluated 110 patients with FNS, including 50 males and 60 females, aged 16-67 years old. The appropriate surgical strategy was selected based on each patient's clinical manifestations, facial nerve function, and imaging characteristics. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.002DOI Listing
February 2019

A retrospective analysis of radiation oncology related scientific articles in the journal Veterinary Radiology and Ultrasound: Trends over 40 years (1976-2015).

Authors:
Koichi Nagata

Vet Radiol Ultrasound 2019 Feb 18. Epub 2019 Feb 18.

College of Veterinary Medicine, Department of Veterinary Biosciences & Diagnostic Imaging, The University of Georgia, Athens, GA 30602.

The journal Veterinary Radiology & Ultrasound is a veterinary specialty journal devoted to the fields of veterinary diagnostic imaging and radiation oncology. The purpose of this retrospective, observational study is to evaluate progressive trends in radiation oncology articles published in Veterinary Radiology & Ultrasound during the 40-year period (1976-2015) and describe a shift of trends through several viewpoints. This 40-year period was divided into four subperiods: Period 1 (1976-1985), Period 2 (1986-1995), Period 3 (1996-2005), and Period 4 (2006-2015). Read More

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http://dx.doi.org/10.1111/vru.12716DOI Listing
February 2019

The prevalence and diagnosis of 'stereoblindness' in adults less than 60 years of age: a best evidence synthesis.

Ophthalmic Physiol Opt 2019 Mar;39(2):66-85

School of Optometry, University of California, Berkeley, USA.

Purpose: Stereoscopic vision (or stereopsis) is the ability to perceive depth from binocular disparity - the difference of viewpoints between the two eyes. Interestingly, there are large individual differences as to how well one can appreciate depth from such a cue. The total absence of stereoscopic vision, called 'stereoblindness', has been associated with negative behavioural outcomes such as poor distance estimation. Read More

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http://dx.doi.org/10.1111/opo.12607DOI Listing

Rehabilitation needs and activity limitations of adults with a visual impairment entering a low vision rehabilitation service in England.

Ophthalmic Physiol Opt 2019 Mar;39(2):113-126

Department of Vision & Hearing Sciences, Anglia Ruskin University, Cambridge, UK.

Purpose: To evaluate outcome measures of the Participation and Activity Inventory (PAI) in a sample of adults with acquired visual impairment entering vision rehabilitation. Both Priority Scores, indicating level of rehabilitative need, and Person Measures, indicating goal difficulty, were considered.

Methods: Participants were newly registered adults with visual impairment within Leicestershire, United Kingdom. Read More

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http://dx.doi.org/10.1111/opo.12606DOI Listing

[Magnetic Resonance Imaging of the Orbital Cavity: Indications and Diagnostic Possibilities].

Klin Monbl Augenheilkd 2019 Feb 18. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

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http://dx.doi.org/10.1055/a-0849-0000DOI Listing
February 2019

Vasoactive Agents for the Management of Variceal Bleeding: A Mixed Treatment Comparison Network Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials.

Drug Res (Stuttg) 2019 Feb 18. Epub 2019 Feb 18.

School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji Islands.

Background: Vasoactives such as terlipressin, somatostatin, vasopressin, octreotide and nitrates are commonly used to treat variceal bleeding. The present study is a network meta-analysis comparing the efficacy and safety of the above vasoactive agents for treating variceal bleeding.

Methods: Electronic databases were searched for appropriate randomized clinical trials evaluating vasoactives in cirrhotic patients with variceal bleeding. Read More

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http://dx.doi.org/10.1055/a-0846-3071DOI Listing
February 2019

Science Meets Clinical Practice.

Hamostaseologie 2019 Feb 18;39(1):4-5. Epub 2019 Feb 18.

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http://dx.doi.org/10.1055/s-0039-1677839DOI Listing
February 2019

Changes and Challenges.

Hamostaseologie 2019 Feb 18;39(1):1-3. Epub 2019 Feb 18.

Division of Experimental and Clinical Hemostasis, Hemotherapy and Transfusion Medicine, and Hemophilia Comprehensive Care Center, Institute of Transplantation Diagnostics and Cell Therapy, Heinrich Heine University Medical Center, Düsseldorf, Germany.

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http://dx.doi.org/10.1055/s-0039-1678526DOI Listing
February 2019

[Guidelines of the German Respiratory Society for Diagnosis and Treatment of Adults Suffering from Acute, Subacute and Chronic Cough].

Pneumologie 2019 Feb 18. Epub 2019 Feb 18.

Facharztforum Fürth.

The present 2019 S2k consensus guideline of the German Respiratory Society was written - in contrast to the predecessor more general S3 guidelines from 2004 and 2010 - for pneumologists, since 2014 the German College of General Practitioners and Family Physicians (DEGAM) published his own cough guidelines.The guideline contains 48 recommendations agreed by consensus and 16 statements, which are explained in the background text in the following nine chapters: epidemiology, physiology, classification, acute, subacute or chronic cough, diagnostics and therapy; an extra chapter was dedicated to chronic idiopathic cough. Further emphasis of the guideline is the physiology of cough in anticipation of the introduction of new drugs, as well as detailed treatises on cough triggered by affections in the upper respiratory tract or by gastroesophageal reflux. Read More

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http://dx.doi.org/10.1055/a-0808-7409DOI Listing
February 2019

[Coincidence of Advance Directive and Organ Donor Consent: What Do The Persons Concerned Want? A Survey of German Elderly Citizens].

Gesundheitswesen 2019 Feb 18. Epub 2019 Feb 18.

Palliative and Supportive Care Service, Lausanne University Hospital, Lausanne, Switzerland.

Aims: In the case of acute brain injury, decision-making uncertainties can arise when both an advance decision to refuse treatment and a prior consent to post-mortem organ donation are present. It is yet unknown how the persons concerned view this potential conflict. The present study aims to investigate how frequent this situation is, whether the persons concerned are aware of the potential conflict and what they would prioritize. Read More

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http://dx.doi.org/10.1055/a-0837-0882DOI Listing
February 2019

Annals for Hospitalists Inpatient Notes - Clinical Pearls-Acute Pancreatitis.

Authors:
Pramod K Garg

Ann Intern Med 2019 Feb;170(4):HO2-HO3

All India Institute of Medical Sciences, New Delhi, India (P.K.G.).

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http://dx.doi.org/10.7326/M19-0008DOI Listing
February 2019

Balancing Protection and Free Movement of Personal Data: The New European Union General Data Protection Regulation.

Ann Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Clinical Effectiveness Research Group, Oslo University Hospital, Oslo, Norway (N.H.).

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http://dx.doi.org/10.7326/M18-2782DOI Listing
February 2019

A Cost-Effectiveness Analysis of Vaccination for Prevention of Herpes Zoster and Related Complications: Input for National Recommendations.

Ann Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Centers for Disease Control and Prevention, Atlanta, Georgia (R.H., A.G., I.R.O., F.Z., K.D.).

Background: The U.S. Advisory Committee on Immunization Practices recently developed recommendations for use of a new recombinant zoster vaccine (RZV). Read More

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http://dx.doi.org/10.7326/M18-2347DOI Listing
February 2019

Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: Adverse developmental programming by early-life exposures might account for higher blood pressure (BP) in children born extremely preterm. We assessed associations between nutrition, growth and hyperglycemia early in infancy, and BP at 6.5 years of age in children born extremely preterm. Read More

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http://dx.doi.org/10.1038/s41390-019-0341-8DOI Listing
February 2019

The Cost of Hypoglycemia Associated With Type 2 Diabetes Mellitus in Taiwan.

Value Health Reg Issues 2019 Feb 15;18:84-90. Epub 2019 Feb 15.

Lilly Diabetes, Eli Lilly and Co (Taiwan), Taipei, Taiwan.

Objectives: To quantify the incremental burden of patients with type 2 diabetes mellitus (T2DM) and a hypoglycemic event in Taiwan using the National Health Insurance Research Database.

Methods: Data from 2000 through 2013 with an index period of 2001 through 2012 from the National Health Insurance Research Database's 2-million-patient sample were used. Using a nested case-control study design, patients were indexed if they reported a diagnosis of T2DM during the index period. Read More

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http://dx.doi.org/10.1016/j.vhri.2019.01.002DOI Listing
February 2019

Therapeutic drug monitoring of teicoplanin using an LC-MS/MS method: Analysis of 421 measurements in a naturalistic clinical setting.

J Pharm Biomed Anal 2019 Feb 4;167:161-165. Epub 2019 Feb 4.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Pharmacology & Therapeutics, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Teicoplanin is a glycopeptide antibiotic used for treatment of severe Gram-positive bacterial infection. The aim of this study was to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for therapeutic drug monitoring (TDM) of teicoplanin and to review our clinical experience. We established an LC-MS/MS method to analyze serum concentration of teicoplanin using simple protein precipitation with a 5 min run time for each sample. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.001DOI Listing
February 2019

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia.

Environ Int 2019 Feb 15;126:24-36. Epub 2019 Feb 15.

National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece. Electronic address:

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma.

Methods: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene.

Results: We identified 650 CpG sites whose methylation correlates strongly (FDR < 0. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.068DOI Listing
February 2019

Analysis of National Presentations of Surgical Case Series Discussions: What Matters to Surgeons?

J Surg Res 2019 Feb 15;238:240-247. Epub 2019 Feb 15.

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address:

Background: Although the surgical case series is a useful study design for surgical disciplines, elements of its presentation have not been standardized with a widely accepted reporting guideline. Hence, case series may not include all components necessary for surgeons to best interpret their results. We aimed to determine core elements of case series through qualitative analysis of discussions after presentations at national meetings. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.037DOI Listing
February 2019

Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China.

Environ Res 2019 Feb 11;172:81-88. Epub 2019 Feb 11.

Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2(nd) Road, Yuexiu District, Guangzhou 510080, China. Electronic address:

Exposure to chemicals may affect liver enzyme to increase the risk of liver diseases. Perfluoroalkyl acids (PFAAs) are one kind of persistent organic pollutants with hepatotoxic effect in organism. However, data is scarce to characterize the hepatotoxic effects of specific structural PFAA isomers in general population. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.013DOI Listing
February 2019

Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials.

Breast 2019 Jan 31;44:135-143. Epub 2019 Jan 31.

DPH, Instituto Nacional de Salud Pública, Av. Universidad 655, Sta. Ma. Ahuacatitlán, C.P. 62100, Cuernavaca, Morelos, Mexico. Electronic address:

Objective: Depressive symptoms are common comorbidities among breast cancer (BC) patients. Non-pharmacological therapies (NPTs) such as exercise and psychotherapy may reduce depressive symptoms; however, the evidence is inconclusive. The objective of this study is to evaluate if NPTs reduce depressive symptoms among BC patients. Read More

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http://dx.doi.org/10.1016/j.breast.2019.01.006DOI Listing
January 2019

Clinical and neuroimaging features of the m.10197G>A mtDNA mutation: New case reports and expansion of the phenotype variability.

J Neurol Sci 2019 Feb 6;399:69-75. Epub 2019 Feb 6.

IRCCS Fondazione Stella Maris, viale del Tirreno 331, 56128 Calambrone, Pisa, Italy.

Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relatively common etiology of Leigh-like syndrome (LS). With a few exceptions, descriptions of the clinical spectrum of specific mutations in CI are scarce. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.010DOI Listing
February 2019

Measuring anti-HLA antibody active concentration and affinity by surface plasmon resonance: Comparison with the luminex single antigen flow beads and T-cell flow cytometry crossmatch results.

Mol Immunol 2019 Feb 15;108:34-44. Epub 2019 Feb 15.

CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France; Immuno ConcEpT, UMR CNRS 5164, 146 rue Léo Saignat, Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, Bordeaux, France.

Background: Although the Luminex single antigen flow beads (SAFB) and the flow cytometry crossmatch (FCXM) are the most sensitive assays used for anti-HLA antibodies characterization in transplant recipients, their semi-quantitative fluorescence read-out is not closely linked to graft outcome.

Methods: Surface plasmon resonance (SPR) was implemented to determine truly quantitative parameters of five human monoclonal anti-class I HLA antibodies (mAbs): first the active concentration and then the binding constants. The results were compared to those obtained with SAFB and T-cell FCXM (T-FCXM). Read More

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http://dx.doi.org/10.1016/j.molimm.2019.02.006DOI Listing
February 2019

Evaluation of a collaborative testing approach to objective structured clinical examination (OSCE) in undergraduate nurse education: A survey study.

Nurse Educ Pract 2019 Jan 28;35:111-116. Epub 2019 Jan 28.

School of Health Sciences, University of Tasmania, Launceston, Tasmania, 7250, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nepr.2019.01.009DOI Listing
January 2019

Autistic traits impact on olfactory processing in adolescent girls with Anorexia Nervosa restricting type.

Psychiatry Res 2019 Feb 11;274:20-26. Epub 2019 Feb 11.

IRCCS Fondazione Stella Maris, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The correct functioning of the chemosensory pathway is pivotal for the attitude towards feeding. In some neuropsychiatric disorders, abnormalities of the sensory processing dramatically affect feeding behavior; however, evidences for an olfactory involvement in Anorexia Nervosa (AN) are still controversial. We administered a complete olfactory testing battery, the Sniffin' Sticks Extended Test, to a cohort of 19 girls with Restrictive Anorexia Nervosa (AN-R) and 19 healthy controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.026DOI Listing
February 2019

Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

J Psychiatr Res 2019 Feb 8;111:169-185. Epub 2019 Feb 8.

Brain Research Center, Ankara University, Ankara, Turkey. Electronic address:

Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.022DOI Listing
February 2019

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

Seizure 2019 Feb 8;66:31-35. Epub 2019 Feb 8.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

Purpose: Late-onset non-lesional focal epilepsy, defined as new-onset seizures in patients older than 60 years, is diagnosed increasingly more often in relation to aging of the population. It has been attributed mainly to occult cerebral small vessel disease (SVD), although high levels of evidence to support this notion are lacking. This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.004DOI Listing
February 2019

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

Seizure 2019 Jan 28;66:26-30. Epub 2019 Jan 28.

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address:

Purpose: This study aimed to investigate the genetic etiology of epilepsy in a cohort of Chinese children.

Methods: Targeted next-generation sequencing (NGS) was performed for 120 patients with unexplained epilepsy, including 71 patients with early-onset epileptic encephalopathies, and 16 patients with Dravet syndrome (including three patients with a Dravet-like phenotype) but without SCN1A pathogenic variants.

Results: Pathogenic variants of 14 genes were discovered in 22 patients (18%). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.025DOI Listing
January 2019

Hdepda: An acyclic adjuvant potentiates meropenem activity in vitro against metallo-β-lactamase-producing enterobacterales.

Eur J Med Chem 2019 Feb 1;167:367-376. Epub 2019 Feb 1.

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address:

Metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales (CRE) pose an emerging threat to public health worldwide. An effective inhibitor of MBLs is therefore urgently needed for clinical use. In this study, two acyclic pyridine-containing ligands, Hdedpa and compound 8, were discovered with excellent activities when combined with meropenem (MEM) against MBL (bla and bla)-producing clinical isolates, including Escherichia coli, Citrobacter freundii, Proteus mirabilis, Enterobacter cloacae and Klebsiella pneumoniae. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.083DOI Listing
February 2019

The safest and most efficacious route of tranexamic acid administration in total joint arthroplasty: A systemic review and network meta-analysis.

Thromb Res 2019 Feb 11;176:61-66. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Singapore General Hospital, Singapore.

Introduction: Blood loss in Total Joint Arthroplasty can be significant and often under-estimated. This study aims to investigate the safety and efficacy of different routes of tranexamic acid (TXA) administration in reducing blood transfusion after Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA). The secondary aim is to find the safest and most efficacious route and dose of TXA. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.006DOI Listing
February 2019

A changing landscape: Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006-2015.

Thromb Res 2019 Feb 13;176:46-53. Epub 2019 Feb 13.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University and Aalborg University Hospital, Denmark. Electronic address:

Background: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available.

Objectives: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.009DOI Listing
February 2019

Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.

Thromb Res 2019 Feb 12;176:39-45. Epub 2019 Feb 12.

Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address:

Introduction: Fluid resuscitation is a cornerstone of severe sepsis management, however there are many uncertainties surrounding the type and volume of fluid that is administered. The entire spectrum of coagulopathies can be seen in sepsis, from asymptomatic aberrations to fulminant disseminated intravascular coagulation (DIC). The aim of this study was to determine if fluid resuscitation with saline contributes to the haemostatic derangements in an ovine model of endotoxemic shock. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.015DOI Listing
February 2019

The senescence-associated secretory phenotype and its regulation.

Cytokine 2019 Feb 15;117:15-22. Epub 2019 Feb 15.

Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada; CRCHUM, 900 Saint-Denis - Room R10.432, Montréal, QC H2X 0A9, Canada. Electronic address:

The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound healing and tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.013DOI Listing
February 2019

Generation of human iPSCs from fetal prostate fibroblasts HPrF.

Stem Cell Res 2019 Feb 7;35:101405. Epub 2019 Feb 7.

Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address:

Human induced pluripotent stem cell line was generated from commercially available primary human prostate fibroblasts HPrF derived from a fetus, aged 18-24 weeks of gestation. The fibroblast cell line was reprogrammed with Yamanaka factors (OCT4, SOX2, c-MYC, KLF4) using CytoTune™-iPS 2.0 Sendai Reprogramming Kit. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101405DOI Listing
February 2019

Grading of hepatocellular carcinoma using 3D SE-DenseNet in dynamic enhanced MR images.

Comput Biol Med 2019 Feb 4;107:47-57. Epub 2019 Feb 4.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China. Electronic address:

Background: Clinical histological grading of hepatocellular carcinoma (HCC) differentiation is of great significance in clinical diagnoses, treatments, and prognoses. However, it is challenging for radiologists to evaluate HCC gradings from medical images.

Purpose: In this study, a novel deep neural network was developed by combining the squeeze-and-excitation networks (SENets) in a three-dimensional (3D) densely connected convolutional network (DenseNet), which is referred to as a 3D SE-DenseNet, for the classification of HCC grading using enhanced clinical magnetic resonance (MR) images obtained from two different clinical centers. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.01.026DOI Listing
February 2019

Quantifying lung ultrasound comets with a convolutional neural network: Initial clinical results.

Comput Biol Med 2019 Feb 7;107:39-46. Epub 2019 Feb 7.

Biomedical Engineering, School of Science and Engineering, Tulane University, New Orleans, LA, USA. Electronic address:

Lung ultrasound comets are "comet-tail" artifacts appearing in lung ultrasound images. They are particularly useful in detecting several lung pathologies and may indicate the amount of extravascular lung water. However, the comets are not always well defined and large variations in the counting results exist between observers. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.02.002DOI Listing
February 2019

Antipsychotic-minocycline-acetylcysteine combination for positive, cognitive, and negative symptoms of schizophrenia.

Asian J Psychiatr 2019 Feb 12;40:100-102. Epub 2019 Feb 12.

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 2300 I St NW, 20037, Washington, DC, USA. Electronic address:

Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Meta-analyses of randomized controlled trials (RCTs) with minocycline and NAC have shown some efficacy signal for positive, cognitive, and negative symptoms of schizophrenia. Hence, the combination may be more effective than either medication alone. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.007DOI Listing
February 2019

Mental Pain Questionnaire: An item response theory analysis.

J Affect Disord 2019 Feb 11;249:226-233. Epub 2019 Feb 11.

Department of Health Sciences, University of Florence, Italy; Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, the Netherlands. Electronic address:

Background: The Mental Pain Questionnaire (MPQ) is a self-report questionnaire developed to assess mental pain. The aim of the present study was to test the clinimetric properties of the MPQ.

Methods: A sample of 200 migraine outpatients were enrolled; homogeneity of MPQ was assessed by Mokken Analysis; item-level severity and item-level sensitivity were calculated via Two-Parameter Logistic model; Total Information Function was evaluated to assess reliability of MPQ; internal consistency was calculated via Cronbach's alpha and Sijtsma and Molenaar rho; sensitivity and specificity were assessed via Receiver Operating Characteristic curves. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.030DOI Listing
February 2019

Assessment of perimenopausal depression: A review.

J Affect Disord 2019 Feb 11;249:216-222. Epub 2019 Feb 11.

Clinical Psychology and Psychotherapy, University of Zurich, Binzmühlestrasse 14, Zurich 8050, Switzerland; URPP Dynamics of Healthy Aging Research Priority Program, University of Zurich, Zurich, Switzerland. Electronic address:

Background: Within the female life cycle, the perimenopause is considered as a critical period for the development of depression. Prevalence rates are particularly high during this phase. Perimenopausal depression is characterized by affective symptoms as well as menopause-specific somatic complaints. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.029DOI Listing
February 2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Neurobiol Aging 2019 Jan 26;77:37-43. Epub 2019 Jan 26.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. Electronic address:

There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast administration (100, 250, 1000 μg) in a double-blind, placebo-controlled, 4-way crossover design. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.014DOI Listing
January 2019

The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.

Neurobiol Aging 2019 Jan 21;77:26-36. Epub 2019 Jan 21.

Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Many individuals live to older ages without clinical impairment. It is unknown whether brain pathologies in these individuals are associated with subtle clinical deficits. We analyzed the brains of 161 clinically normal (Clinical Dementia Rating score = 0) older individuals enrolled in the Mayo Clinic Patient Registry or Study of Aging. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.008DOI Listing
January 2019

Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a.

Int Immunopharmacol 2019 Feb 15;69:373-381. Epub 2019 Feb 15.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Kaempferol is a kind of bioflavonoid exerts diverse pharmacological activities, including anti-apoptotic and anti-inflammatory activities. Kaempferol has been recognized as an effective agent for alleviating the clinical symptoms of osteoarthritis (OA). This study aimed to provide evidence that Kaempferol has potential in the management of OA. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.014DOI Listing
February 2019

Quantification of second generation direct-acting antivirals daclatasvir, elbasvir, grazoprevir, ledipasvir, simeprevir, sofosbuvir and velpatasvir in human plasma by UPLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 28;1110-1111:15-24. Epub 2019 Jan 28.

Dept of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.

Direct-acting antivirals (DAA) have markedly improved the treatment of hepatitis C, with a series of DAA combinations available for treatment. A sensitive method by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous quantification of seven commonly used DAAs, daclatasvir (DAC), elbasvir (ELB), grazoprevir (GZR), ledipasvir (LDV), simeprevir (SIM), sofosbuvir (SOF), velpatasvir (VEL) and the primary analyte of interest of SOF (GS-331007) in EDTA plasma. Adequate chromatographic separation with well-defined peaks for all eight analytes was achieved with an Acquity UPLC BEH C18 column (1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.024DOI Listing
January 2019

Chemometrics coupled with UPLC-MS/MS for simultaneous analysis of markers in the raw and processed Fructus Xanthii, and application to optimization of processing method by BBD design.

Phytomedicine 2018 Dec 15;57:191-202. Epub 2018 Dec 15.

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China. Electronic address:

Background: As a widely used toxic traditional herbal medicine, the quality of the Fructus Xanthii must be well controlled to ensure the clinical therapeutic efficacy and safety.

Aims: A rapid, and sensitive using ultra-high performance liquid chromatography to triple quadrupole tandem mass spectrometry (UPLC-MS/MS) in selected reaction monitoring (SRM) mode was developed and validated for simultaneous quantitation of determination active and toxic ingredients form processed by stir-frying and raw materials of Fructus Xanthii.

Methods: Chromatographic separation of all targeted compound was performed on Waters ACQUITY UPLC HSS T3 column (50 mm × 2. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.020DOI Listing
December 2018

Revised management of advanced primary colon cancer: Case series of 2 patients.

Int J Surg Case Rep 2019 Feb 10;55:233-238. Epub 2019 Feb 10.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: The resection of a primary colon cancer has the opportunity to cure the patient of cancer by complete clearance and absolute containment of disease. Alternatively, if the cancer resection does not provide clearance and containment it will eventuate in local recurrence and peritoneal dissemination.

Methods: Culpability of recurrence of colorectal cancer is difficult to determine. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.046DOI Listing
February 2019
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