4,383,356 results match your criteria Clinical & Experimental Immunology [Journal]


Variation in the Height of Rectal Cancers According to the Diagnostic Modalities.

Ann Coloproctol 2019 Feb 28;35(1):24-29. Epub 2019 Feb 28.

Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Although the height of a rectal tumor above the anal verge (tumor height) partly determines the treatment strategy, no practical standard exists for reporting this. We aimed to demonstrate the differences in tumor height according to the diagnostic modality used for its measurement.

Methods: We identified 100 patients with rectal cancers located within 15 cm of the anal verge who had recorded tumor heights measured by using magnetic resonance imaging (MRI), colonoscopy, and digital rectal examination (DRE). Read More

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http://dx.doi.org/10.3393/ac.2018.07.31DOI Listing
February 2019

Does the Different Locations of Colon Cancer Affect the Oncologic Outcome? A Propensity-Score Matched Analysis.

Ann Coloproctol 2019 Feb 28;35(1):15-23. Epub 2019 Feb 28.

Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Purpose: We evaluate the prognostic value of primary tumor location for oncologic outcomes in patients with colon cancer (CC).

Methods: CC patients treated with curative surgery between 2009 and 2012 were classified into 2 groups: right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Recurrence-free survival (RFS) and overall survival (OS) were examined based on tumor stage. Read More

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http://dx.doi.org/10.3393/ac.2018.07.25DOI Listing
February 2019

How to Achieve a Higher Pathologic Complete Response in Patients With Locally Advanced Rectal Cancer Who Receive Preoperative Chemoradiation Therapy.

Authors:
Suk-Hwan Lee

Ann Coloproctol 2019 Feb 28;35(1):3-8. Epub 2019 Feb 28.

Department of Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

The current standard of care for treating patients with locally advanced rectal cancer includes preoperative chemoradiation therapy (PCRT) followed by a total mesorectal excision and postoperative adjuvant chemotherapy. A subset of these patients has achieved a pathologic complete response (pCR) and they have shown improved disease-free and overall survival compared to non-pCR patients. Thus, many efforts have been made to achieve a higher pCR through PCRT. Read More

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http://dx.doi.org/10.3393/ac.2019.02.17DOI Listing
February 2019

Gene dosage of DAX-1, determining in sexual differentiation: duplication of DAX-1 in two sisters with gonadal dysgenesis.

Mol Biol Rep 2019 Mar 16. Epub 2019 Mar 16.

Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Cra 7 No. 40-62, Bogotá, 110231, Colombia.

Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism. Copy number variation and functional effects of the duplication were done by MLPA multiplex ligation-dependent probe amplification and real time PCR. DAX-1, also known as dosage sensitive sex reversal gene (DSS), is considered the most likely candidate gene involved in XY gonadal dysgenesis when overexpressed. Read More

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http://dx.doi.org/10.1007/s11033-019-04758-yDOI Listing

Pre- and post-transplant ponatinib for a patient with acute megakaryoblastic blast phase chronic myeloid leukemia with T315I mutation who underwent allogeneic hematopoietic stem cell transplantation.

Int J Hematol 2019 Mar 16. Epub 2019 Mar 16.

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

A 42-year-old female complaining of fever and night sweats was diagnosed with acute megakaryoblastic blast phase chronic myeloid leukemia (CML-BP). She had massive splenomegaly, left pleural effusion with leukemia infiltration, and moderate myelofibrosis. She received dasatinib monotherapy (140 mg/day) as for induction, after which her pleural effusion rapidly resolved and hematological remission was achieved. Read More

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http://dx.doi.org/10.1007/s12185-019-02628-8DOI Listing

Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure-Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite.

Eur J Drug Metab Pharmacokinet 2019 Mar 16. Epub 2019 Mar 16.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.

Background And Objectives: Dichotomization of pharmacokinetic exposure measures in exposure-response relationship studies provides results that are interpretable in clinical care. Several methods exist in the literature on how to define the cut-off values needed for the dichotomization process. Commonly, the sample median is utilized to define the dichotomizing value; however, statistical methods based on the exposure metric and its association with the outcome are argued to result in a more proper definition of the optimal cut-point. Read More

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http://dx.doi.org/10.1007/s13318-019-00550-2DOI Listing

Reaction times of children having nitrous oxide inhalation sedation for dental procedures.

Eur Arch Paediatr Dent 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Dentistry, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Inhalation sedation (IHS), using nitrous oxide and oxygen, is a commonly used form of pharmacological behaviour management in paediatric dentistry. Previous studies suggest that IHS causes a delay in reaction time, which recovers to baseline within 10 min.

Aim: To observe the reaction times (RT) of children before and after undergoing IHS for dental treatment. Read More

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http://dx.doi.org/10.1007/s40368-019-00433-9DOI Listing

Switching "Real-World" Diabetes Patients to Degludec from Other Basal Insulins Provides Different Clinical Benefits According to Their Baseline Glycemic Control.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

eSwiss Medical and Surgical Center, St Gallen, Switzerland.

Introduction: The stable, ultra-long duration of action of insulin degludec (degludec) minimizes fluctuations in glucose-lowering activity over the daily (24-h) dosing period, and comparative studies with other basal insulins suggest that these properties translate into a lower risk of hypoglycemia at equivalent levels of glycemic control. Results from the real-world European multicenter, retrospective chart review study of 2550 patients with type 1 and type 2 diabetes (T1D and T2D) in routine clinical care EU-TREAT (NCT02662114) showed that patients benefited from improved glycemic control and significantly reduced rates of hypoglycemia following a switch to degludec.

Methods: In this post hoc analysis, EU-TREAT patients were stratified into good (≤ 7. Read More

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http://dx.doi.org/10.1007/s12325-019-00916-7DOI Listing
March 2019
1 Read

Assessing the Role of Anti rh-GAA in Modulating Response to ERT in a Late-Onset Pompe Disease Cohort from the Italian GSDII Study Group.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Clinical and Experimental Medicine, UOC di Neurologia e Malattie Neuromuscolari, University of Messina, Messina, Italy.

Introduction: Patients with late-onset Pompe disease (LOPD) receiving enzyme replacement therapy (ERT) may develop IgG antibodies against alglucosidase alpha (anti-rhGAA) in the first 3 months of treatment. The exact role of these antibodies in modulating efficacy of ERT in this group of patients is still not fully understood. To assess whether anti rh-GAA antibodies interfere with ERT efficacy, we studied a large Italian cohort of LOPD patients. Read More

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http://dx.doi.org/10.1007/s12325-019-00926-5DOI Listing

Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

Introduction: There are some controversies about treatment modalities in osteoarthritis (OA), including chondroitin sulfate (CS). The objective of this study was to determine whether CS is effective at alleviating pain and improving function in patients with knee OA and to identify the factors that explain inconsistencies in clinical trial results.

Methods: We conducted a systematic review of randomized, placebo-controlled trials, searching the databases Medline, Cochrane central register for controlled trials and Scopus. Read More

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http://dx.doi.org/10.1007/s12325-019-00921-wDOI Listing

Bloating and Abdominal Distension: Clinical Approach and Management.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Functional abdominal bloating and distension (FABD) are common gastrointestinal complaints, encountered on a daily basis by gastroenterologists and healthcare providers. Functional abdominal bloating is a subjective sensation that is commonly associated with an objective abdominal distension. FABD may be diagnosed as a single entity (the sole or cardinal complaint) or may overlap with other functional gastrointestinal disorders such as functional constipation, irritable bowel syndrome, and functional dyspepsia. Read More

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http://dx.doi.org/10.1007/s12325-019-00924-7DOI Listing

The Case for the Use of Patient and Caregiver Perception of Change Assessments in Rare Disease Clinical Trials: A Methodologic Overview.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Casimir, Plymouth, MA, USA.

Introduction: The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome measures. Incorporating qualitative research into rare disease clinical trials may help sponsors, regulators, payers, and prescribers to better understand the real-world and patient-specific impact of a potential therapy. Read More

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http://dx.doi.org/10.1007/s12325-019-00920-xDOI Listing

Survival, Motor Function, and Motor Milestones: Comparison of AVXS-101 Relative to Nusinersen for the Treatment of Infants with Spinal Muscular Atrophy Type 1.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

AveXis, Inc., Bannockburn, IL, USA.

Introduction: Infants with spinal muscular atrophy (SMA) type 1 typically face a decline in motor function and a severely shortened life expectancy. Clinical trials for SMA type 1 therapies, onasemnogene abeparvovec (AVXS-101) and nusinersen, demonstrated meaningful improvements in efficacy (e.g. Read More

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http://dx.doi.org/10.1007/s12325-019-00923-8DOI Listing

Foot-and-mouth disease in Southern Ghana: occurrence and molecular characterization of circulating viruses.

Trop Anim Health Prod 2019 Mar 16. Epub 2019 Mar 16.

OIE Sub-Saharan Africa Regional Reference Laboratory for Foot-and-Mouth Disease, Botswana Vaccine Institute, Private Bag 0031, Gaborone, Botswana.

Foot-and-mouth disease (FMD) is considered to be endemic in Ghana. However, our knowledge of the local epidemiology of the disease is restricted by a lack of serological information and data for characterized viruses causing field outbreaks. In order to improve our understanding of the prevailing situation, this study was initiated to establish the FMD viruses (FMDV) circulating in the country. Read More

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http://dx.doi.org/10.1007/s11250-019-01864-8DOI Listing

Anaesthetic Factors Affecting Outcome After Bariatric Surgery, a Retrospective Levelled Regression Analysis.

Obes Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, AZ Sint Jan Brugge-Oostende, B-8000, Brugge, Belgium.

Background: Deep neuromuscular block (NMB) and opioid-free anaesthesia (OFA) improve surgical workspace and reduce post-operative opioid consumption, but its impact on perioperative outcomes is unknown. This observational study compared complications and healthcare resource utilization after bariatric surgery, with or without continuous deep NMB or OFA.

Methods: We included all 9246 patients who underwent laparoscopic bariatric surgery at our institution from January 2009 to February 2017. Read More

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http://dx.doi.org/10.1007/s11695-019-03763-1DOI Listing

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease.

J Neuroimmune Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.

Chronic and debilitating neurodegenerative diseases, such as Parkinson's disease (PD), impose an immense medical, emotional, and economic burden on patients and society. Due to a complex interaction between genetic and environmental risk factors, the etiology of PD remains elusive. However, the cumulative evidence emerging from clinical and experimental research over the last several decades has identified mitochondrial dysfunction, oxidative stress, neuroinflammation, and dysregulated protein degradation as the main drivers of PD neurodegeneration. Read More

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http://dx.doi.org/10.1007/s11481-019-09844-3DOI Listing

Metaphyseal cones and sleeves in revision total knee arthroplasty: Two sides of the same coin? Complications, clinical and radiological results-a systematic review of the literature.

Musculoskelet Surg 2019 Mar 16. Epub 2019 Mar 16.

Clinica Ortopedica - Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, GE, Italy.

Revision total knee arthroplasty (rTKA) is increasing of relevance in orthopaedic surgeon daily practice and this trend is likely to continue in the years ahead. The aim of this systematic review of English literature is to summarize and compare indications, complications, clinical and radiological results of metaphyseal cones and sleeves in management of bone loss in rTKA. Retrospective or prospective studies with at least 1 year of follow-up (FU) were included. Read More

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http://dx.doi.org/10.1007/s12306-019-00598-yDOI Listing

Transcutaneous transmission of photobiomodulation light to the spinal canal of dog as measured from cadaver dogs using a multi-channel intra-spinal probe.

Lasers Med Sci 2019 Mar 16. Epub 2019 Mar 16.

LiteCure LLC, Carlsbad, CA, 92008, USA.

The target level photobiomodulation (PBM) irradiances along the thoracic to lumbar segment of the interior spinal canal in six cadaver dogs resulting from surface illumination at 980 nm were measured. Following a lateral hemi-laminectomy, a flexible probe fabricated on a plastic tubular substrate of 6.325 mm diameter incorporating nine miniature photodetectors was embedded in the thoracic to lumbar segment of the spinal canal. Read More

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http://dx.doi.org/10.1007/s10103-019-02761-0DOI Listing

Patient-reported symptoms following mastectomy alone or lumpectomy plus radiation for early stage breast cancer: a cohort study.

Breast Cancer Res Treat 2019 Mar 16. Epub 2019 Mar 16.

Cancer Care Ontario, Toronto, Canada.

Purpose: Studies examining symptom differences between surgeries for breast cancer patients rarely incorporate the effects of adjuvant treatment choice. We sought to understand differences in patient-reported symptoms between lumpectomy plus radiation and mastectomy in the year following surgery.

Methods: This cohort study used linked administrative datasets. Read More

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http://dx.doi.org/10.1007/s10549-019-05196-xDOI Listing
March 2019
1 Read

ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population.

Neurol Sci 2019 Mar 16. Epub 2019 Mar 16.

Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.

Background: Α number of genetic variants have been associated with amyotrophic lateral sclerosis (ALS). A recent study supports that rs591486 across the ERCC6L2 gene and exposure to pesticides seem to have a joint effect on the development of Parkinson's disease, a disease which shares a few common characteristics with ALS.

Objective: To detect a possible contribution of rs591486 ERCC6L2 to ALS. Read More

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http://dx.doi.org/10.1007/s10072-019-03825-3DOI Listing

The description and definition of Emergency Department Pharmacist Practitioners in the United Kingdom (the ENDPAPER study).

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

Division of Pharmacy and Optometry, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Background Due to a shortage of emergency department doctors and nurses, hospitals have started to employ pharmacists who have additional clinical skills, known as Emergency Department Pharmacist Practitioners, to help deliver services. Objective To describe, compare and define the Emergency Department Pharmacist Practitioner role. Setting UK emergency departments. Read More

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http://dx.doi.org/10.1007/s11096-019-00799-2DOI Listing

Pharmacists' views on the upscheduling of codeine-containing analgesics to 'prescription only' medicines in Australia.

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

Background Codeine is the most commonly used opioid worldwide, and is available over-the-counter (OTC) in many countries. There is continual debate regarding the risk:benefit profile for OTC codeine. In Australia, codeine containing analgesics became 'prescription only medicine' from February 2018. Read More

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http://dx.doi.org/10.1007/s11096-019-00804-8DOI Listing

A Randomized Controlled Trial of a Rapid Re-housing Intervention for Homeless Persons Living with HIV/AIDS: Impact on Housing and HIV Medical Outcomes.

AIDS Behav 2019 Mar 16. Epub 2019 Mar 16.

New York City Department of Social Services, New York, NY, USA.

We conducted a randomized controlled trial to determine whether, for homeless persons living with HIV/AIDS (PLWHA), rapid re-housing can improve housing and HIV viral suppression more than standard housing assistance. We recruited 236 PLWHA from HIV emergency housing in New York City (NYC) and randomized them to: (1) Enhanced Housing Placement Assistance (EHPA), i.e. Read More

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http://dx.doi.org/10.1007/s10461-019-02461-4DOI Listing

Implementing an Updated "Break the Cycle" Intervention to Reduce Initiating Persons into Injecting Drug Use in an Eastern European and a US "opioid epidemic" Setting.

AIDS Behav 2019 Mar 16. Epub 2019 Mar 16.

HIV Center for Clinical and Behavioral Studies at The New York State Psychiatric Institute and Columbia University, New York, USA.

We tested the hypothesis that an updated "Break the Cycle" (BtC) intervention, based in social cognitive theory and motivational interviewing, would reduce the likelihood that current persons who inject drugs (PWID) would assist persons who do not inject drugs (non-PWID) with first injections in Tallinn, Estonia and Staten Island, New York City. 402 PWID were recruited, a baseline interview covering demographics, drug use, and assisting non-PWID with first drug injections was administered, followed by BtC intervention. 296 follow-up interviews were conducted 6 months post-intervention. Read More

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http://dx.doi.org/10.1007/s10461-019-02467-yDOI Listing

Effects of NOP-Related Ligands in Nonhuman Primates.

Handb Exp Pharmacol 2019 Mar 17. Epub 2019 Mar 17.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

The nociceptin/orphanin FQ peptide (NOP) receptor-related ligands have been demonstrated in preclinical studies for several therapeutic applications. This article highlights (1) how nonhuman primates (NHP) were used to facilitate the development and application of positron emission tomography tracers in humans; (2) effects of an endogenous NOP ligand, nociceptin/orphanin FQ, and its interaction with mu opioid peptide (MOP) receptor agonists; and (3) promising functional profiles of NOP-related agonists in NHP as analgesics and treatment for substance use disorders. NHP models offer the most phylogenetically appropriate evaluation of opioid and non-opioid receptor functions and drug effects. Read More

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http://dx.doi.org/10.1007/164_2019_211DOI Listing

Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.

Handb Exp Pharmacol 2019 Mar 17. Epub 2019 Mar 17.

Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

Effective analgesia in neonates is relevant not only because of ethical aspects or empathy, but it is a crucial and integral part of medical and nursing care. However, there is also emerging evidence - although mainly in animal models - on the relation between the exposure to narcotics and impaired neurodevelopmental outcome, resulting in a CATCH-22 scenario. Consequently, a balanced approach is needed with the overarching intention to attain adequate pain management with minimal side effects. Read More

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http://dx.doi.org/10.1007/164_2019_207DOI Listing

Provider Access to Legacy Electronic Anesthesia Records Following Implementation of an Electronic Health Record System.

J Med Syst 2019 Mar 16;43(5):105. Epub 2019 Mar 16.

Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Many hospitals are in the process of replacing their legacy anesthesia information management system (AIMS) with an Electronic Health Record (EHR) system, within which the AIMS is integrated. Using the legacy AIMS security access log table, we studied the extent to which anesthesia providers were accessing historical anesthesia records (January 2006 - March 2017) following implementation of an EHR (April 2017). Statistical analysis was by segmented regression. Read More

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http://dx.doi.org/10.1007/s10916-019-1232-6DOI Listing

Reliability and validity of self-reported questionnaires to measure pain and disability in adults with neck pain and its associated disorders: part 3-a systematic review from the CADRE Collaboration.

Eur Spine J 2019 Mar 16. Epub 2019 Mar 16.

UOIT-CMCC Centre for Disability Prevention and Rehabilitation, University of Ontario Institute of Technology (UOIT), 2000 Simcoe St. N., Oshawa, ON, L1H 7K4, Canada.

Purpose: To determine the reliability and validity of self-reported questionnaires to measure pain and disability in adults with grades I-IV neck pain and its associated disorders (NAD).

Methods: We updated the systematic review of the 2000-2010 Bone and Joint Decade Task Force on Neck Pain and its Associated Disorders and systematically searched databases from 2005 to 2017. Independent reviewers screened and critically appraised studies using standardized tools. Read More

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http://dx.doi.org/10.1007/s00586-019-05949-8DOI Listing

Surgical treatment of type II odontoid fractures in elderly patients: a comparison of anterior odontoid screw fixation and posterior atlantoaxial fusion using the Magerl-Gallie technique.

Eur Spine J 2019 Mar 16. Epub 2019 Mar 16.

Department of Spine Surgery, Zentralklinik Bad Berka, Robert-Koch-Allee 9, 99437, Bad Berka, Germany.

Purpose: This single-centre retrospective study compared anterior odontoid screw fixation and posterior atlantoaxial fusion in the surgical treatment of type II B odontoid fractures according to Grauer in elderly patients.

Methods: Between 1994 and 2014, 133 consecutive patients above 60 years presenting with type II B odontoid fracture were treated surgically in our department. They were divided retrospectively into two groups. Read More

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http://dx.doi.org/10.1007/s00586-019-05946-xDOI Listing

Prediction of brace effect in scoliotic patients: blinded evaluation of a novel brace simulator-an observational cross-sectional study.

Eur Spine J 2019 Mar 16. Epub 2019 Mar 16.

Anatoscope-Cap-Omega Rond-Point Benjamin Franklin, 34960, Montpellier, France.

Purpose: Bracing is the most commonly used treatment for scoliosis. But braces remain predominantly "handcrafted." Our objective was to create a novel brace simulator using a high-fidelity 3D "avatar" of the patient's trunk. Read More

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http://dx.doi.org/10.1007/s00586-019-05948-9DOI Listing

Relationships Between Fear of Cancer Recurrence and Lifestyle Factors Among Cancer Survivors.

J Cancer Educ 2019 Mar 16. Epub 2019 Mar 16.

Betty Irene Moore School of Nursing, University of California, Davis, Betty Irene Moore Hall, 2570 48th Street, Sacramento, CA, 95817, USA.

We examine the relationships between fear of cancer recurrence (FCR), physical activity, smoking status, and engagement in healthier habits in a US population-based sample of post-treatment cancer survivors. We used data from the 2011 Medical Expenditure Panel Survey (MEPS) Experience with Cancer Survivorship Supplement. Multivariable logistic regression was used to test the relationship of FCR to physical activity, smoking status, and engagement in healthier habits. Read More

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http://dx.doi.org/10.1007/s13187-019-01509-2DOI Listing

The roles of FGF21 in atherosclerosis pathogenesis.

Rev Endocr Metab Disord 2019 Mar 16. Epub 2019 Mar 16.

Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

FGF21 is a peptide hormone that regulates homeostasis of lipid and glucose as well as energy metabolism. It is mainly expressed and secreted in liver and adipose tissues, and it is expressed in lower amounts in the aorta. Recent clinical and preclinical studies indicate increased serum FGF21 levels in atherosclerosis patients. Read More

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http://dx.doi.org/10.1007/s11154-019-09488-xDOI Listing

Evaluation of risk factors associated to detection of Blastocystis sp. in fecal samples in population from Barcelona, Spain: a case-control study.

Eur J Clin Microbiol Infect Dis 2019 Mar 16. Epub 2019 Mar 16.

Department of Infectious Diseases, Vall d'Hebron University Hospital, PROSICS Barcelona, P° Vall d'Hebron 119-129, 08035, Barcelona, Spain.

Blastocystis sp. is the most common intestinal parasite isolated in humans. The aim of the study was to describe the risk factors associated to Blastocystis sp. Read More

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http://dx.doi.org/10.1007/s10096-019-03532-zDOI Listing

Electrospun essential oil-polycaprolactone nanofibers as antibiofilm surfaces against clinical Candida tropicalis isolates.

Biotechnol Lett 2019 Mar 16. Epub 2019 Mar 16.

Biotechnology Division, Biology Department, Faculty of Sciences, Hacettepe University, 06800, Beytepe, Ankara, Turkey.

Objective: As an approach to prevent biofilm infections caused by Candida tropicalis on various surfaces, determination of effect of biodegradable polycaprolactone nanofibers (PCLNFs) with different concentrations of two different essential oils were tested in this study.

Results: Both of the tested essential oils exhibited antifungal effect (minimal inhibitory concentration; 0.25-0. Read More

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http://dx.doi.org/10.1007/s10529-019-02660-yDOI Listing

Ramucirumab as a second line therapy for advanced HCC: a significant achievement or a wasted opportunity for personalised therapy?

Invest New Drugs 2019 Mar 16. Epub 2019 Mar 16.

Division of Medical Oncology, Department of Onco-Hematology, IRCCS-CROB, Referral Cancer Center of Basilicata, via Padre Pio 1, 85028, Rionero, Vulture, PZ, Italy.

The second line treatment of hepatocellular carcinoma (HCC) has recently become an exciting area of interest since new emerging options have demonstrated survival benefits versus placebo. Unfortunately, predictive biomarkers are unavailable for these treatments. Ramucirumab, a monoclonal antibody against VEGFR-2, has demonstrated overall survival superiority against placebo as a second line therapy for patients with AFP > 400 ng/ml in the recent REACH-2 trial. Read More

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http://dx.doi.org/10.1007/s10637-019-00760-0DOI Listing

Comparison between the effects of selenomethionine and S-adenosylmethionine in preventing cholestasis-induced rat liver damage.

Amino Acids 2019 Mar 16. Epub 2019 Mar 16.

Department of Biochemistry, Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000, Niš, Serbia.

We aimed to evaluate whether two methionine-related compounds, S-adenosylmethionine (SAM), and selenomethionine (SM), could lessen liver damage induced by regurgitated bile in a model of rat bile duct ligation (BDL). Hepatoprotective potentials of S-adenosylmethionine and selenomethionine were estimated based on the changes of serum liver damage parameters (aminotransferases, alkaline phosphatase, gamma-glutamyltranspeptidase and lactate dehydrogenase activity, and bilirubin concentration), tissue oxidative [xanthine oxidase (XO) and catalase activity, thiobarbituric acid reactive substances (TBARS) levels] and inflammatory [tumor necrosis factor-alfa (TNF-α) concentration] parameters, and morphological liver tissue alterations that follow cholestasis. The treatment regimens proved themselves able to prevent significant liver damage induced by cholestasis. Read More

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http://dx.doi.org/10.1007/s00726-019-02716-3DOI Listing

Clinical assessment of the GNAS mutation status in patients with intraductal papillary mucinous neoplasm of the pancreas.

Surg Today 2019 Mar 16. Epub 2019 Mar 16.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by cystic dilation of the pancreatic duct, caused by mucin hypersecretion, with slow progression via the adenoma-carcinoma sequence mechanism. Mutation of GNAS at codon 201 is found exclusively in IPMNs, occurring at a rate of 41-75%. Recent advances in molecular biological techniques have demonstrated that GNAS mutation might play a role in the transformation of IPMNs after the appearance of neoplastic cells, rather than in the tumorigenesis of IPMNs. Read More

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http://dx.doi.org/10.1007/s00595-019-01797-7DOI Listing

Heparin prevents oxidative stress-induced apoptosis in human decidualized endometrial stromal cells.

Med Mol Morphol 2019 Mar 16. Epub 2019 Mar 16.

Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan.

Clinical trials have shown that administering heparin during the luteal phase has beneficial effects on implantation and live birth rates. Heparin exerts direct effects on decidual human endometrial stromal cells (HESCs), which are independent of its anticoagulant effect. However, the accurate effects of heparin on the decidualization process remain unidentified. Read More

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http://dx.doi.org/10.1007/s00795-019-00220-xDOI Listing

Reirradiation for diffuse intrinsic pontine glioma: a systematic review and meta-analysis.

Childs Nerv Syst 2019 Mar 16. Epub 2019 Mar 16.

Department of Neurosurgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.

Background: Diffuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with dismal prognosis despite initial radiation therapy (RT). The clinical consequences of attempting reirradiation (reRT) in these patients to alleviate both symptomatology and improve prognosis are currently unclear. Thus, the aim of this systematic review and meta-analysis was to clarify the efficacy and safety of reRT in DIPG. Read More

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http://dx.doi.org/10.1007/s00381-019-04118-yDOI Listing

A novel method to address the association between received dose intensity and survival outcome: benefits of approaching treatment intensification at a more individualised level in a trial of the European Osteosarcoma Intergroup.

Cancer Chemother Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Mathematical Institute Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands.

Purpose: There is lack of consensus on the prognostic value of received high dose intensity in osteosarcoma survivorship. Many studies have not shown a clear survival benefit when dose intensity is increased. The aim of this study is to go beyond chemotherapy intensification by arm-wide escalation of intended dose and/or compression of treatment schedule, while conversely addressing the relationship between treatment intensity and survival at the patient level. Read More

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http://dx.doi.org/10.1007/s00280-019-03797-3DOI Listing

Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction.

Knee Surg Sports Traumatol Arthrosc 2019 Mar 16. Epub 2019 Mar 16.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Purpose: Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.

Methods: Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Read More

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http://dx.doi.org/10.1007/s00167-019-05468-5DOI Listing

Young age and high BMI are predictors of early revision surgery after primary anterior cruciate ligament reconstruction: a cohort study from the Swedish and Norwegian knee ligament registries based on 30,747 patients.

Knee Surg Sports Traumatol Arthrosc 2019 Mar 16. Epub 2019 Mar 16.

Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: To analyse patient-related risk factors for 2-year ACL revision after primary reconstruction. The hypothesis was that younger athletes would have a higher incidence of an early ACL revision.

Methods: This prospective cohort study was based on data from the Norwegian and Swedish National Knee Ligament Registries and included patients who underwent primary ACL reconstruction from 2004 to 2014. Read More

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http://dx.doi.org/10.1007/s00167-019-05487-2DOI Listing

Treatment of osteochondral defects: chondrointegration of metal implants improves after hydroxyapatite coating.

Knee Surg Sports Traumatol Arthrosc 2019 Mar 16. Epub 2019 Mar 16.

Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institute, Stockholm, Sweden.

Purpose: The treatment of osteochondral defects in joint cartilage remains challenging due to its limited repair capacity. This study presents a metallic osteochondral plug with hydroxyapatite (HA)-coated cap edges for improved implant-tissue contact. The hypothesis was that improved attachment prevents from synovial fluid-influx and thereby avoids osteolysis and resulting implant instability. Read More

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http://dx.doi.org/10.1007/s00167-019-05484-5DOI Listing

Cancer as a risk factor for urinary tract calculi: a retrospective cohort study using 'The Health Improvement Network' : Cancer and urinary tract calculi.

Urolithiasis 2019 Mar 16. Epub 2019 Mar 16.

Department of Urology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.

Purpose: Urolithiasis is a common condition that poses significant morbidity to patients. There are similarities in the development of certain cancers and urinary tract calculi (UTC), however, little is known about their temporal relationship. This study aims to identify if cancer is a risk factor for the development of UTC. Read More

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http://dx.doi.org/10.1007/s00240-019-01127-zDOI Listing

Intramedullary screw fixation for simple displaced olecranon fractures.

Eur J Trauma Emerg Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of Surgery, St Antonius Hospital, Utrecht, The Netherlands.

Purpose: Olecranon fractures are common and typically require surgical fixation due to displacement generated by the pull of the triceps muscle. The most common techniques for repairing olecranon fractures are tension-band wiring or plate fixation, but these methods are associated with high rates of implant-related soft-tissue irritation. Another treatment option is fixation with an intramedullary screw, but less is known about surgical results using this strategy. Read More

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http://dx.doi.org/10.1007/s00068-019-01114-4DOI Listing

Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices.

Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Internal Medicine III, Division of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Background: Ventricular assist devices (VAD) are increasingly used as long-term treatment for advanced heart failure. However, survival after VAD implantation is still unsatisfactory, and no specific outpatient follow-up algorithms have been formally established. Here, we evaluate the effect of an intensified follow-up protocol (IFUP) on survival rates and VAD-associated complications. Read More

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http://dx.doi.org/10.1007/s00392-019-01451-9DOI Listing

Measuring spinal mobility in early axial spondyloarthritis: does it matter?

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To investigate the frequency and order of impairment of spinal mobility measures (SMMs) and their cross-sectional and longitudinal usefulness in early axial spondyloarthritis.

Methods: SMMs measurements of patients from the DESIR (5-year data) and SPACE (2.6 (1. Read More

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http://dx.doi.org/10.1093/rheumatology/kez026DOI Listing

Testing threat-to-efficacy ratios in health communications about cardiovascular disease among an older population.

Health Promot Int 2019 Mar 16. Epub 2019 Mar 16.

School of Psychology, Trinity College Dublin, Dublin, Ireland.

To test threat-to-efficacy ratios within health communications about cardiovascular disease (CVD) for older individuals. Participants were randomly assigned to one of six messages: (i) 'standard' message with 1/1 threat-to-efficacy ratio, (ii) 'low efficacy' message with 1/0 threat-to-efficacy ratio, (iii) 'low threat' message with 0/1 threat-to-efficacy ratio, (iv) 'high efficacy' message with 1/2 threat-to-efficacy ratio; (v) 'high threat' message with 2/1 threat-to-efficacy ratio and (vi) 'overload' message with 2/2 threat-to-efficacy ratio. Participants had to be of 60 years of age or older (N = 242, Male = 92, Age: M = 68. Read More

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http://dx.doi.org/10.1093/heapro/daz019DOI Listing

Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes.

Nephrol Dial Transplant 2019 Mar 15. Epub 2019 Mar 15.

Department of Medicine, Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: Residual kidney function (RKF) is thought to exert beneficial effects through clearance of uremic toxins. However, the level of native kidney function where clearance becomes negligible is not known.

Methods: We aimed to assess whether levels of nonurea solutes differed among patients with 'clinically negligible' RKF compared with those with no RKF. Read More

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http://dx.doi.org/10.1093/ndt/gfz042DOI Listing
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