62,239 results match your criteria Clinica Chimica Acta [Journal]


Can simple and low-cost motor function assessments help in the diagnostic suspicion of Duchenne muscular dystrophy?

J Pediatr (Rio J) 2019 Apr 19. Epub 2019 Apr 19.

Universidade Federal do Rio de Janeiro (UFRJ), Departamento de Pediatria, Genética Clínica, Rio de Janeiro, RJ, Brazil.

Background: Duchenne muscular dystrophy, an X-linked genetic disease, leads to progressive muscle weakness mainly in the lower limbs. Motor function tests help to monitor disease progression. Can low-cost, simple assessments help in the diagnostic suspicion of Duchenne muscular dystrophy? The authors aim to define the sensitivity of time to rise from the floor, time to walk 10meters (10MWT), and time to run 10meters (10MRT), evaluating them as eventual diagnostic screening tools. Read More

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http://dx.doi.org/10.1016/j.jped.2019.02.003DOI Listing

Diaphragmatic Ultrasonography, a Novel Approach in Critical Care: A Proposal for a New Weaning Index.

Ultrasound Q 2019 Apr 12. Epub 2019 Apr 12.

Department of Critical Care Medicine, Medica Sur Clinic & Foundation.

The evaluation of the diaphragm in critically ill patients is simple and noninvasive and has shown good repeatability. The aim of the study was to generate a predictive index for successful weaning (ULDIMex) from invasive mechanical ventilation (IMV) based on an ultrasonographic diaphragmatic assessment before performing a spontaneous breathing test. We recruited patients who required IMV and who were candidates for weaning from ventilation. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000442DOI Listing

Correlation Between Anterior Corneal Elevation Differences in Main Meridians and Corneal Astigmatism.

Eye Contact Lens 2019 Apr 15. Epub 2019 Apr 15.

Department of Optics II (Optometry and Vision) (L.B., G.C.), Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Clínica Oftalmológica Doctor Lens (L.B.), Madrid, Spain; Department of Optics, Pharmacology and Anatomy (D.P.), University of Alicante, Alicante, Spain; and Department of Ophthalmology (Oftalmar) (D.P.), Vithas Medimar International Hospital, Alicante, Spain.

Purpose: To assess the correlation between anterior corneal elevation (ACE) and anterior corneal astigmatism (ACA) obtained with two different topographers in healthy subjects at different corneal diameters.

Methods: A retrospective, comparative, and observational study was conducted. Topography data from 305 patients obtained with the Oculus Pentacam (Oculus, Wetzlar, Germany) and Sirius (CSO, Florence, Italy) systems were collected. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000613DOI Listing

Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue.

J Oncol 2019 17;2019:7406078. Epub 2019 Mar 17.

Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.

The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. Read More

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http://dx.doi.org/10.1155/2019/7406078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533PMC

Resting Energy Expenditure Measured by Indirect Calorimetry in Obese Patients: Variation Within Different BMI Ranges.

JPEN J Parenter Enteral Nutr 2019 Apr 22. Epub 2019 Apr 22.

Nutrition Therapy Multidisciplinary Team/RJ-Clínica São Vicente, Rio de Janeiro, Brazil.

Background: The adequate provision of energy for obese patients by estimation without indirect calorimetry (IC) is challenging. The goal was to establish values of kilocalories per kilogram (kcal/kg) for patients in different ranges of body mass index (BMI [kg/m ]) comparable to resting energy expenditure (REE [kcal/kg/d]) measurements by IC.

Methods: In 63 overweight (OW) hospitalized patients with BMIs (25. Read More

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http://dx.doi.org/10.1002/jpen.1589DOI Listing

LEADERSHIP AND INNOVATION IN THE NAVIGATION PLAN OF THE ENDOCRINOLOGY AND NUTRITION SPECIALTY.

Authors:
Javier Salvador

Endocrinol Diabetes Nutr 2019 May;66(5):275-277

Departamento de Endocrinología y Nutrición. Clínica Universidad de Navarra. Pamplona. CIBEROBN. Instituto de Salud Carlos III. Presidente de la Comisión Nacional de la Especialidad de Endocrinología y Nutrición. Electronic address:

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http://dx.doi.org/10.1016/j.endinu.2019.03.007DOI Listing

Efficacy and Safety of Ixekizumab in a Real-Life Practice: A Retrospective Bicentric Study.

Actas Dermosifiliogr 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

Background: Ixekizumab has proven efficacy and safety for the treatment of psoriasis in clinical trials. The aim of this study was to evaluate its effectiveness and safety in routine clinical practice.

Methods: Retrospective study of all patients treated with ixekizumab in 2 dermatology departments in the city of Valencia, Spain. Read More

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http://dx.doi.org/10.1016/j.ad.2019.02.006DOI Listing

Impact of biofilm production on polymyxin B susceptibility among Pseudomonas aeruginosa clinical isolates.

Infect Control Hosp Epidemiol 2019 Apr 22:1-2. Epub 2019 Apr 22.

Curso de Especialização em Microbiologia Clínica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

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http://dx.doi.org/10.1017/ice.2019.85DOI Listing

Consumption of Meat, Fish, Dairy Products, Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409,885 Participants in the Pan-European EPIC Cohort.

Circulation 2019 Apr 22. Epub 2019 Apr 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Background: There is uncertainty about the relevance of animal foods to the etiology of ischemic heart disease (IHD). We examined meat, fish, dairy products and eggs and risk for IHD in the pan-European EPIC cohort.

Methods: A prospective study of 409,885 men and women in nine European countries. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038813DOI Listing

Mast cells-induced immunopathology in recurrent pregnancy losses.

Am J Reprod Immunol 2019 Apr 21:e13128. Epub 2019 Apr 21.

Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061.

Problem: Mast cells (MC) have been known to play an important role in inflammation and angiogenesis by secreting numerous mediators, such as proteases, gelatinases and proteoglycans. Three different MC subtypes were found in the endometrial layers of the uterus. In this study, we aim to investigate the role of endometrial MCs in recurrent pregnancy losses (RPL). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13128
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http://dx.doi.org/10.1111/aji.13128DOI Listing
April 2019
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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

Myostatin regulates the fibrogenic phenotype of hepatic stellate cells via c-jun N-terminal kinase activation.

Dig Liver Dis 2019 Apr 17. Epub 2019 Apr 17.

Dipartimento di Medicina Sperimentale Clinica, University of Florence, Florence, Italy; Research Center Denothe, University of Florence, Florence, Italy. Electronic address:

Background & Aims: Myostatin is mainly expressed in skeletal muscle, where it negatively regulates trophism. This myokine is implicated in the pathophysiology of nonalcoholic steatohepatitis, an emerging cause of liver fibrosis. In this study we explored the effects of myostatin on the biology of hepatic stellate cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193011
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http://dx.doi.org/10.1016/j.dld.2019.03.002DOI Listing
April 2019
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The Combined Use of Pleural Fluid Parameters Improves Diagnostic Accuracy in Complicated Pleural Infection/Empyema.

Arch Bronconeumol 2019 Apr 17. Epub 2019 Apr 17.

Servicio de Neumología, Complejo Hospitalario Clínico Universitario de Santiago de Compostela, Grupo Interdisciplinar de Investigación en Neumología. Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, A Coruña, España.

Introduction: Identifying infectious pleural effusions (IPE) that will progress to complicated infection or empyema is challenging. The purpose of this study was to determine whether a model based on multiple biochemical parameters in pleural fluid can predict which IPEs will produce empyema.

Methods: A prospective study was performed of all cases of IPEs treated in our unit. Read More

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http://dx.doi.org/10.1016/j.arbres.2019.02.025DOI Listing

Iridocorneal angle assessment using Swept-Source OCT in a patient with anterior granulomatous uveitis.

Arch Soc Esp Oftalmol 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.

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http://dx.doi.org/10.1016/j.oftal.2019.03.003DOI Listing

Bleeding risk assessment for stroke patients on antithrombotic therapy.

Clin Investig Arterioscler 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Virgen Macarena, Sevilla, España.

Introduction: After an ischemic cerebrovascular event the risk of new ischemic events is high, therefore antithrombotic therapy are indicated to prevent stroke recurrence.

Discussion: Despite its clear benefit, these therapies increase the risk of bleeding. Therefore, it is essential to identify high hemorrhagic risk patients. Read More

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http://dx.doi.org/10.1016/j.arteri.2019.01.006DOI Listing

Early Syphilis: New Diagnostic Approaches in a Changing Scenario.

Actas Dermosifiliogr 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Dermatología, Servicio de Dermatología, Hospital Universitario Virgen Macarena, Sevilla, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2019.03.002DOI Listing

The INTERACT Trial: Long-term results of a randomised trial on preoperative capecitabine-based radiochemotherapy intensified by concomitant boost or oxaliplatin, for cT2 (distal)-cT3 rectal cancer.

Radiother Oncol 2019 May 7;134:110-118. Epub 2019 Feb 7.

Radiation Oncology Department, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.

Background And Purpose: Capecitabine-based radiochemotherapy (cbRCT) is standard for preoperative long-course radiochemotherapy of locally advanced rectal cancer. This prospective, parallel-group, randomised controlled trial investigated two intensification regimens. cT4 lesions were excluded. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.11.023DOI Listing
May 2019
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The predictive dysphagia score (PreDyScore) in the short- and medium-term post-stroke: a putative tool in PEG indication.

Neurol Sci 2019 Apr 19. Epub 2019 Apr 19.

Unità Operativa Dietetica e Nutrizione Clinica, IRCCS per l'Oncologia e la Neurologia, Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: We performed an evaluation of dysphagia in an unselected series of strokes to identify factors causing persisting dysphagia at 1 month after onset and to formulate a predictive score.

Methods: We evaluated the association between dysphagia and clinical aspects (univariate analysis) at the 7th and 30th days after admission. We performed a multivariate logistic regression at the 30th day on the factors that were significant. Read More

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http://dx.doi.org/10.1007/s10072-019-03896-2DOI Listing

A Wearable Compression Device to Normalise Calf Muscle Pump Function in Chronic Venous Insufficiency for Each Postural Position.

Eur J Vasc Endovasc Surg 2019 Apr 17. Epub 2019 Apr 17.

Professor Emeritus, Department of Dermatology, Vienna Medical University, Vienna, Austria.

Background: For the currently used compression therapy, the applied compression pressure is usually inadequate to exert an effective impact on the veins in different body positions. The aim was to assess the venous ejection fraction achieved by a new compression device which automatically adjusts the interface pressure to body position in an acute experimental setting.

Methods: A new portable, battery driven compression device providing pressure adjusted to allow for body position, and connected to a less or very stiff calf cuff wrap was tested. Read More

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http://dx.doi.org/10.1016/j.ejvs.2018.12.017DOI Listing

SEEN guidelines for the management and prevention of acute adrenal insufficiency.

Endocrinol Diabetes Nutr 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Endocrinología y Nutrición, Hospital Clínico, Barcelona, España. Electronic address:

Acute adrenal insufficiency (AAI) is a potentially fatal medical emergency whose prevention and treatment should be known by all medical professionals. AAI is an underdiagnosed condition because of its non-specific symptoms, but its diagnosis and early treatment with glucocorticoids is vital. It may be triggered by a de novo deficiency in cortisol synthesis or occur secondarily to omission of hormone replacement therapy (corticosteroids) or inadequate adjustment of the dose required in stress situations in patients previously diagnosed with adrenal insufficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
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http://dx.doi.org/10.1016/j.endinu.2019.01.004DOI Listing
April 2019
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Clinical guide for the diagnosis and follow-up of myotonic dystrophy type 1, MD1 or Steinert's disease.

Neurologia 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.

Background And Objectives: Steinert's disease or myotonic dystrophy type 1 (MD1), (OMIM 160900), is the most prevalent myopathy in adults. It is a multisystemic disorder with dysfunction of virtually all organs and tissues and a great phenotypical variability, which implies that it has to be addressed by different specialities with experience in the disease. The knowledge of the disease and its management has changed dramatically in recent years. Read More

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http://dx.doi.org/10.1016/j.nrl.2019.01.001DOI Listing

Dopamine drives binge-like consumption of a palatable food in experimental Parkinsonism.

Mov Disord 2019 Apr 19. Epub 2019 Apr 19.

Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.

Background: Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.

Objectives: We hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior. Read More

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http://dx.doi.org/10.1002/mds.27683DOI Listing

The role of procalcitonin outside of the Intensive Care Unit (ICU): a multidisciplinary approach.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2978-2985

Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Clinica delle Malattie Infettive Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Biochemical markers are commonly used in medicine to guide diagnostic investigation or therapy duration and/or monitor treatment efficacy. Due to the emergence and spread of antimicrobial resistance, markers able to prompt a more rational use of antimicrobial therapy are regarded with the greatest attention. Procalcitonin (PCT) certainly stands out among others, yet its role must be better established especially outside of the critical care area. Read More

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http://www.europeanreview.org/article/17579
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http://dx.doi.org/10.26355/eurrev_201904_17579DOI Listing
April 2019
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Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate to severe plaque-type psoriasis: Results from extension phase of the SUPREME study.

Br J Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Dermatology Unit, Department of Biomedical Sciences, Humanitas University, Via Alessandro Manzoni 113, 20089, Rozzano-Milan, Italy.

Recent studies have shown that biological drugs approved for treating psoriasis and psoriatic arthritis are not effective in all patients, and that variations in the genome have been associated with different clinical responses or side effects. HLA-Cw6 gene is associated with more severe and early-onset psoriasis. Recent reports have shown that HLA-Cw6 status predicts efficacy of some biologic treatments in psoriasis patients. Read More

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http://dx.doi.org/10.1111/bjd.18013DOI Listing

Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen .

Front Cell Infect Microbiol 2019 2;9:83. Epub 2019 Apr 2.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.

is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult management worldwide. In addition, isolates from this species frequently present reduced susceptibility to azole and echinocandin drugs. For this reason, it is necessary to develop new antifungal strategies to better control the disease caused by this yeast. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00083
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http://dx.doi.org/10.3389/fcimb.2019.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454888PMC
April 2019
1 Read

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
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Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4 T Cell Loss in HIV-1 Elite Controllers.

Front Microbiol 2019 2;10:673. Epub 2019 Apr 2.

Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Elite controllers (EC) are able to control HIV-1 replication to extremely low levels (<50 HIV-1 RNA copies/mL) in the absence of antiretroviral therapy. However, some EC experience CD4 T cell loss and/or lose their ability to control HIV-1 over the course of infection. High levels of HIV-1 proviral diversity, activated T cells and proinflammatory cytokines were pointed out as relevant biomarkers for detection of EC at risk of virologic/immunologic progression. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00673
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http://dx.doi.org/10.3389/fmicb.2019.00673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454058PMC
April 2019
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Effects of Vitamin E-Stabilized Ultra High Molecular Weight Polyethylene on Oxidative Stress Response and Osteoimmunological Response in Human Osteoblast.

Front Endocrinol (Lausanne) 2019 3;10:203. Epub 2019 Apr 3.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

High Crosslink process was introduced in the development of joint prosthetic devices, in order to decrease the wear rate of ultrahigh molecular weight polyethylene (UHMWPE), but it also triggers the formation of free radicals and oxidative stress, which affects the physiological bone remodeling, leading to osteolysis. Vitamin E stabilization of UHMWPE was proposed to provide oxidation resistance without affecting mechanical properties and fatigue strength. The aim of this study is to evaluate the antioxidant effect of vitamin E added to UHMWPE on oxidative stress induced osteolysis, focusing in particular on the oxidative stress response in correlation with the production of osteoimmunological markers, Sclerostin and DKK-1, and the RANKL/OPG ratio compared to conventional UHMWPE wear debris. Read More

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http://dx.doi.org/10.3389/fendo.2019.00203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457167PMC

Identification of Normal and Injured Anterolateral Ligaments of the Knee: A Systematic Review of Magnetic Resonance Imaging Studies.

Arthroscopy 2019 Apr 15. Epub 2019 Apr 15.

Clínica do Dragão, Espregueira-Mendes Sports Centre-FIFA Medical Centre of Excellence, Porto, Portugal; Dom Henrique Research Centre, Porto, Portugal; Orthopaedics Department of Minho University, Minho, Portugal; 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal. Electronic address:

Purpose: To identify the normal and injured magnetic resonance imaging appearance of the anterolateral ligament (ALL).

Methods: A systematic review was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The PubMed and Cochrane Library electronic databases were used to search for studies that reported the imaging outcomes of the appearance of the ALL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07498063183100
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http://dx.doi.org/10.1016/j.arthro.2018.10.120DOI Listing
April 2019
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Tumors Distributed Linearly Near the Scapula in a Young Man.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, España.

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http://dx.doi.org/10.1016/j.ad.2018.04.012DOI Listing

Flower and Milium: A Tatoo With Points in Relief.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Unidad de Gestión Clínica de Dermatología y Venereología, Complejo Hospitalario Universitario de Granada, Granada, España.

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http://dx.doi.org/10.1016/j.ad.2018.03.033DOI Listing

Neural correlates of cognitive dysfunction in fibromyalgia patients: Reduced brain electrical activity during the execution of a cognitive control task.

Neuroimage Clin 2019 Apr 8;23:101817. Epub 2019 Apr 8.

Departamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Objectives: Fibromyalgia (FM) is a generalized chronic pain syndrome of unknown aetiology. Although FM patients frequently complain of cognitive dysfunction, this is one of the least studied symptoms. Research on brain activity associated with the perceived cognitive impairment is particularly scarce. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101817DOI Listing
April 2019
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The effect of adjunctive nutraceuticals in bipolar disorder: A systematic review of randomized placebo-controlled trials.

J Affect Disord 2019 Apr 8;252:334-349. Epub 2019 Apr 8.

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Italy; U.O.C. Clinica Psichiatrica, A.O.U. Policlinico-Vittorio Emanuele, Presidio "G. Rodolico", Catania, Italy.

Background: Nutraceuticals are a group of compounds of growing interest for mental health professionals. Given the implication of certain nutrients in the onset of bipolar disorder, it has been hypothesized that nutraceuticals might be effective in improving symptoms of the condition (i.e. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.039DOI Listing
April 2019
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Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address:

Background & Aims: Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.014DOI Listing
April 2019
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Exosomes on the border of species and kingdom intercommunication.

Transl Res 2019 Mar 29. Epub 2019 Mar 29.

Consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile; Cells for Cells, Santiago, Chile; Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. Electronic address:

Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that exosomes are key players in cellular communication, carrying source-specific molecules such as proteins, growth factors, miRNA/mRNA, among others. The discovery that exosomes are not bound to intraspecies interactions, but are also capable of interkingdom communication, has once again revolutionized the field of exosomes research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193007
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http://dx.doi.org/10.1016/j.trsl.2019.03.008DOI Listing
March 2019
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Optimizing Periplasmic Expression in Escherichia coli for the Production of Recombinant Proteins Tagged with the Small Metal-Binding Protein SmbP.

Mol Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Universidad Autonoma de Nuevo Leon, Facultad de Ciencias Quimicas, 66455, San Nicolas de los Garza, NL, Mexico.

We have previously shown that the small metal-binding protein (SmbP) extracted from the gram-negative bacterium Nitrosomonas europaea can be employed as a fusion protein for the expression and purification of recombinant proteins in Escherichia coli. With the goal of increasing the amounts of SmbP-tagged proteins produced in the E. coli periplasm, we replaced the native SmbP signal peptide with three different signal sequences: two were from the proteins CusF and PelB, for transport via the Sec pathway, and one was the signal peptide from TorA, for transport via the Tat pathway. Read More

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http://dx.doi.org/10.1007/s12033-019-00176-4DOI Listing

Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro/La antibodies.

Clin Rheumatol 2019 Apr 17. Epub 2019 Apr 17.

Sección Reumatología, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Peron 4190 (C1199ABB), Buenos Aires, Argentina.

Introduction/objectives: Complete congenital atrioventricular block (AVB) may be due to cardiac malformations or the presence of maternal antibodies (autoimmune AVB). Our objective was to estimate the prevalence of autoimmune AVB among all AVB in newborns treated at our hospital. Secondly, we estimated the prevalence of AVB among mothers with anti-Ro/La antibodies and examined the relationship of those fetal AVB with mother's use of hydroxychloroquine during pregnancy. Read More

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http://dx.doi.org/10.1007/s10067-019-04556-8DOI Listing
April 2019
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Sonographic landmarks in hamstring muscles.

Skeletal Radiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Diagnóstico Médico Cantabria (DMC), Santander, Cantabria, Spain.

The ultrasound examination of hamstrings inspires respect due to the connective complexity of their structures, particularly for sonographers who are not used to this kind of study. Therefore, it is important to know the specific ultrasound reference points that facilitate the location of the hamstring structures, dividing them into four areas of interest: (a) tendinous origin of the hamstring, (b) the proximal half, (c) distal and medial half, and (d) distal and lateral half. The origin of the hamstrings is found at the level of the ischial tuberosity. Read More

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http://link.springer.com/10.1007/s00256-019-03208-x
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http://dx.doi.org/10.1007/s00256-019-03208-xDOI Listing
April 2019
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KEYNOTE-024: goodbye to chemotherapy?

Authors:
Rossana Berardi

J Thorac Dis 2019 Mar;11(Suppl 3):S428-S432

Clinica Oncologica, Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Ancona, Italy.

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http://dx.doi.org/10.21037/jtd.2018.11.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424736PMC

OMERACT agreement and reliability study of ultrasonographic elementary lesions in osteoarthritis of the foot.

RMD Open 2019 8;5(1):e000795. Epub 2019 Mar 8.

Scienze Cliniche e Biologiche, Università degli Studi di Torino, Rome, Italy.

Objective: To evaluate the level of agreement on ultrasonographic (US) lesions among highly experienced sonographers as well as the intraobserver and interobserver reliability of inflammatory and structural US lesions in patients with osteoarthritis (OA) of the foot.

Methods: After a systematic literature review, a Delphi survey was performed to test definitions of US lesions in OA of the foot, including inflammatory lesions (ie, synovial hypertrophy [SH], joint effusion [JE], power Doppler signal [PD]), and structural abnormalities (ie, cartilage damage [CD] and osteophytes). Subsequently, the reliability of US in assessing the aforementioned lesions was tested on static images as well as during a live exercise. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443136PMC

Selective Inhibitors of T Cell Receptor Recognition of Antigen-MHC Complexes for Rheumatoid Arthritis.

ACS Med Chem Lett 2019 Apr 13;10(4):644-649. Epub 2019 Mar 13.

Institute of Chemistry of Molecular Recognition (ICRM) - CNR, Rome, Italy.

Autoreactive T cells specific to human collagen type II have a crucial role in the development of rheumatoid arthritis (RA) in the context of MHC class II allele HLA-DRB1-*04. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen bound to the allele MHC of class II may thus represent the target for the development of new drugs against RA. In this study, a structure-based pharmacophore model for potential small molecule inhibitors was developed from protein-protein interface structure. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466834PMC

Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: and Biological Profile.

ACS Med Chem Lett 2019 Apr 8;10(4):450-456. Epub 2019 Mar 8.

Dipartimento di Farmacia, Università di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.

In this work we report the application of the ring-closing metathesis (RCM) to the preparation of two cyclic olefin-bridged analogues of biphalin (Tyr-d-Ala-Gly-Phe-NH-NH ← Phe ← Gly ← d-Ala ← Tyr), using the second generation Grubbs' catalyst. The resulting - and -cyclic isomers were identified, fully characterized, and tested at μ (ΜΟR), δ (DOR), and κ (KOR) opioid receptors and for antinociceptive activity. Both were shown to be full agonists at MOR and potential partial antagonists at DOR, with low potency KOR agonism. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466526PMC

Data from the Human Penguin Project, a cross-national dataset testing social thermoregulation principles.

Sci Data 2019 04 17;6(1):32. Epub 2019 Apr 17.

LIP/PC2S, Université Grenoble Alpes, Grenoble Alpes, France.

In the Human Penguin Project (N = 1755), 15 research groups from 12 countries collected body temperature, demographic variables, social network indices, seven widely-used psychological scales and two newly developed questionnaires (the Social Thermoregulation and Risk Avoidance Questionnaire (STRAQ-1) and the Kama Muta Frequency Scale (KAMF)). They were collected to investigate the relationship between environmental factors (e.g. Read More

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http://dx.doi.org/10.1038/s41597-019-0029-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470130PMC

Association between emergency department length of stay and adverse perioperative outcomes in emergency surgery: a cohort study in two Colombian University hospitals.

BMC Emerg Med 2019 Apr 17;19(1):27. Epub 2019 Apr 17.

Grupo de Cardiología Preventiva, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: In low- and middle-income countries emergency surgery represents a higher proportion of the total number of surgeries and is associated with greater morbidity/mortality. Study aims were to determine if emergency department length of stay (ED-LOS) was associated with adverse perioperative outcomes and if such association varied across patient's risk categories.

Methods: A retrospective cohort study was conducted of adult patients who underwent orthopedic or abdominal emergency surgery at two Colombian University hospitals. Read More

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https://bmcemergmed.biomedcentral.com/articles/10.1186/s1287
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http://dx.doi.org/10.1186/s12873-019-0241-6DOI Listing
April 2019
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Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing
April 2019
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Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007313. Epub 2019 Apr 17.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Leishmaniasis is a zoonotic disease of worldwide relevance. Visceral leishmaniasis is endemic in Brazil, where it is caused by Leishmania infantum with Lutzomyia longipalpis being the most important invertebrate vector. Non-human primates are susceptible to L. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007313DOI Listing

Semantic memory, but not education or intelligence, moderates cognitive aging: a cross-sectional study.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Objective: Aging studies regularly assume that years of education are a protective factor for baseline cognition. In developing countries with specific sociocultural issues, this relationship may not work as expected, and an unmet need remains for alternative resilience factors. This study aimed to analyze different moderators for the relationship between aging and general cognition that could reflect better protective factors. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0290DOI Listing

Predictors of quality of life in Brazilian medical students: a systematic review and meta-analysis.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: To examine predictors associated with quality of life (QoL) in Brazilian medical students.

Methods: PubMed, PsycINFO, EMBASE, LILACS, and Google Scholar were searched for research articles in English or Portuguese published through August 2018. Observational studies that measured QoL with standard instruments were selected. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1516-4446-2018-0116DOI Listing
April 2019
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Biett's sign: a hallmark sign of secondary syphilis.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180475. Epub 2019 Apr 11.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0475-2018DOI Listing
April 2019
4 Reads