60,568 results match your criteria Clinica Chimica Acta [Journal]


In silico Leishmania proteome mining applied to identify drug target potential to be used to treat against visceral and tegumentary leishmaniasis.

J Mol Graph Model 2018 Nov 29;87:89-97. Epub 2018 Nov 29.

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

New therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishmania, but low toxicity in mammalian hosts. In the present study, a Leishmania proteome mining strategy was developed, in order to select new drug targets with low homology to human proteins, but that are considered relevant for the parasite' survival. Read More

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November 2018
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Extracellular FABP4 uptake by endothelial cells is dependent on cytokeratin 1 expression.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

Lipids and Atherosclerosis Research Unit, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Reus, Spain. Electronic address:

Aims: The aim of this study is to determine the physical and functional interplay between fatty acid-binding protein 4 (FABP4) and its membrane receptor-like candidate protein, cytokeratin 1 (CK1), and to determine the effect of hindering CK1-mediated FABP4 cellular uptake on non-disturbed or metabolically stressed endothelial cells.

Methods: We monitored the direct interaction between FABP4 and CK1 using surface plasmon resonance, and the effects of blocking exogenous FABP4 (eFABP4) cellular uptake were determined by using specific siRNA to knock down the expression of CK1 in human umbilical vein endothelial cells (HUVECs). The expression and nuclear translocation of transcription factors involved in oxidative stress (NRF2) and inflammation (p65 subunit of NF-ĸB transcription factor) were determined by Western blotting analysis. Read More

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December 2018
1 Read

[Prevalence of osteoporosis and osteopenia in patients occupationally active].

Acta Ortop Mex 2018 May-Jun;32(3):131-133

Clínica de Detección y Diagnóstico Automatizado, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México.

Background: Osteoporosis is a public health problem worldwide, affecting more than 200 million people. It is estimated that 30 to 50% of postmenopausal women suffer from it. According to the International Osteoporosis Foundation (IOF), osteoporosis is a disease characterized by a decrease in the density and quality of bones. Read More

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December 2018
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[Functional results and complications of the use of the proximal femoral nail in the treatment of intertrochanteric hip fractures].

Acta Ortop Mex 2018 May-Jun;32(3):126-130

Centro de Evaluación de Tecnologías, Universidad CES, Medellín, Colombia.

Introduction: Cephalomedullary nails are used for the treatment of hip fractures; however, there are few studies that allow identifying data on the complications of the use of these devices and the results in terms of restoration of the functionality of the patient.

Methods: A cross-sectional study of patients with femur fracture was conducted during the period from January 2008 to December 2012. Data on demographic and clinical variables were collected. Read More

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December 2018
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Erratum to "Letter to the Editor about the Article: "Still Regarding Anxiety, Depression and Academic Performance: A Study Amongst Portuguese Medical Students Versus Non-Medical Students", by João Moreira de Sousa, Cátia A. Moreira, Diogo Telles-Correia. Acta Med Port. 2018;31:454-62. ".

Acta Med Port 2018 Nov;31(11):702

Hospital Júlio de Matos. Centro Hospitalar Psiquiátrico de Lisboa. Lisboa; Clínica de Psiquiatria e Psicologia Médica. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

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November 2018

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018

A novel transnational fresh oocyte donation (TOD) program based on transport of frozen sperm and embryos.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Clínica EUGIN, Barcelona, Spain.

Study Question: What is the clinical efficacy of an oocyte donation program based on the transportation of frozen semen and embryos between two countries?

Summary Answer: The transnational oocyte donation program is efficient and reliable and it could provide a first-line strategy to overcome the lack of donors in some countries.

What Is Known Already: While there is increasing need for donated oocytes, in many countries the availability of donors is still insufficient to cover the therapeutic demands, and patients are referred abroad for treatment. Since embryo cryopreservation is reliable and efficient, we propose a strategy based on frozen embryos instead of frozen oocytes to satisfy the increasing demand for cross border oocyte donation. Read More

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December 2018

Low serum trough concentrations and high vancomycin MIC in methicillin-sensitive Staphylococcus aureus from hemodialysis patients in Brazil.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Health Sciences Center, Federal University of Espírito Santo (UFES), Marechal Campos Ave., 1468, 29040-090 Vitória, Espírito Santo, Brazil.

Background: The empiric antimicrobial therapy for bacteremia of long-term hemodialysis (HD) outpatients is currently based on the combination of vancomycin and gentamicin because of the high frequency of isolated Staphylococcus species. The vancomycin trough level range from 15 to 20 µg/mL is expected for therapeutic success against methicillin-resistant S. aureus with vancomycin MIC ≥ 1. Read More

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December 2018

Hematological evaluation of free-living golden-headed lion tamarins (Leontopithecus chrysomelas) from an Urban Atlantic Forest.

J Med Primatol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niteroi, RJ, Brazil.

Background: The Atlantic Forest where the animals were captured is surrounded by residences, so this close contact could favor the presence of disease-transmitting pathogens, putting the local population at risk. For these and other factors, it is important to perform laboratory tests enabling the performance of important diagnoses.

Methods: Blood samples of 268 golden-headed lion tamarins (Leontopithecus chrysomelas) inhabiting an Atlantic Forest area in Rio de Janeiro, Brazil, were processed for accessing age and sex influence in hematological parameters and to establish normative hematology values. Read More

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December 2018
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Joint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [F]FDG: version 1.0.

Eur J Nucl Med Mol Imaging 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurology, University Hospital Zurich, Zurich, Switzerland.

These joint practice guidelines, or procedure standards, were developed collaboratively by the European Association of Nuclear Medicine (EANM), the Society of Nuclear Medicine and Molecular Imaging (SNMMI), the European Association of Neurooncology (EANO), and the working group for Response Assessment in Neurooncology with PET (PET-RANO). Brain PET imaging is being increasingly used to supplement MRI in the clinical management of glioma. The aim of these standards/guidelines is to assist nuclear medicine practitioners in recommending, performing, interpreting and reporting the results of brain PET imaging in patients with glioma to achieve a high-quality imaging standard for PET using FDG and the radiolabelled amino acids MET, FET and FDOPA. Read More

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December 2018

Laparoscopic and robotic-assisted repair of retrocaval ureter in children: a multi-institutional comparative study with open repair.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Division of Pediatric Surgery, "Federico II" University of Naples, Via Pansini 5, 80131, Naples, Italy.

Purpose: This retrospective study aimed to report a multi-institutional experience with laparoscopic and robotic-assisted repair of retrocaval ureter in children and to compare outcome of minimally invasive surgery (MIS) with open repair.

Methods: The records of all children, who underwent MIS and open repair of retrocaval ureters in six international pediatric urology units over a 5-year period, were retrospectively collected. Data were grouped according to the operative approach: a laparoscopic group (G1) included five patients, a robotic-assisted group (G2) included four patients, and an open group (G3) included three patients. Read More

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December 2018
2 Reads

Evaluation of RETICs Glaucoma Diagnostic Calculators in Preperimetric Glaucoma.

Transl Vis Sci Technol 2018 Nov 30;7(6):13. Epub 2018 Nov 30.

Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods: All eyes ( = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Read More

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November 2018

Effects of mineralocorticoid and AT-1 receptor antagonism on the aldosterone-renin ratio (ARR) in primary aldosteronism patients (EMIRA Study): rationale and design.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

Clinica dell'Ipertensione Arteriosa, Department of Medicine - DIMED, University of Padova, Padova, Italy.

Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA). However, abandonment of mineralocorticoid-receptor antagonist (MRA) and/or blockers of the renin-angiotensin system can deteriorate control of blood pressure (BP) and hypokalemia. Thus, in consecutive patients with an unambiguous diagnosis of PA in washout from confounding treatments and subtyped by AVS, we will compare within-patient plasma aldosterone and active renin concentration, and the ARR values, measured at baseline, and after a 1-month treatment with MRA alone and combined with an AT-1 receptor blocker (ARB). Read More

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December 2018

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.

J Transl Med 2018 Dec 5;16(1):338. Epub 2018 Dec 5.

Department of Surgery Oncology and Gastroenterology, University of Padova, Padua, Italy.

Background: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis of patients with soft tissue sarcoma.

Patients And Methods: We considered the 14 single nucleotide polymorphisms (SNPs) of 6 core circadian genes that have a minor allele frequency > 5% and that are known to be associated with cancer risk or prognosis. Read More

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December 2018

Mitochondria targeting to oppose the progression of nonalcoholic fatty liver disease.

Biochem Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. Read More

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November 2018

Demographic and clinical characteristics, and adverse reactions of people with overweight and obesity consumers of orlistat, attended by a call center (2009 – 2017).

Medwave 2018 Oct 16;17(6):e7288. Epub 2018 Oct 16.

Consulta Externa de Nutrición Clínica, Hospital Médica Sur, Tlalpan, México. Address: Puente de Piedra 150, Toriello Guerra, Tlalpan, Ciudad de México, México, CP: 14050. Email:

Introduction: Chronic diseases are on the rise and are associated with weight gain. Multidisciplinary strategies are required for its control.

Methods: The design was descriptive, observational and retrospective. Read More

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October 2018

The contribution of the Clinica del Lavoro of Milan to the development of industrial hygiene and toxicology in the twentieth century.

Arch Environ Occup Health 2018 Dec 3:1-12. Epub 2018 Dec 3.

c Department of Clinical Sciences and Community Health , University of Milan and Fondazione IRCCS Ca' Granda Ospedale Maggiore , Milan , Italy.

In 1910, the founder of the Clinica del Lavoro of Milan, Luigi Devoto established a chemistry laboratory in the new institute, sustaining its importance in the study of occupational diseases. In 1948, the new director of the Clinica, Enrico C. Vigliani established the first laboratory of industrial hygiene in Italy, in the years of the economic boom. Read More

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December 2018

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals.

Clin Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Italy.

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. Read More

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December 2018
2 Reads

Desirability of outcome ranking (DOOR) for comparing diagnostic tools and early therapeutic choices in patients with suspected candidemia.

Eur J Clin Microbiol Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l'Oncologia, University of Genoa, Largo R. Benzi, 10, 16132, Genoa, Italy.

Desirability of outcome ranking (DOOR) has been developed for assessing desirability of outcome in interventional studies. However, its possible use in observational studies of the diagnosis and early treatment of infectious diseases has not been explored so far, and it might introduce interesting features in specific scenarios. This was a post hoc analysis of a prospective observational study in intensive care unit patients with sepsis and at risk of candidemia. Read More

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November 2018

Skin nerve α-synuclein deposits in Parkinson's disease and other synucleinopathies: a review.

Authors:
Donadio Vincenzo

Clin Auton Res 2018 Nov 30. Epub 2018 Nov 30.

IRCCS Istituto Delle Scienze Neurologiche di Bologna (Italy), UOC Clinica Neurologica, Via Altura 3, 40139, Bologna, Italy.

Purpose: The in vivo diagnosis of synucleinopathies is an important research aim since clinical diagnostic criteria show low accuracy. The skin innervation, especially the autonomic subdivision, is a useful region to search for abnormal α-syn aggregates in synucleinopathies since the peripheral sympathetic nerves can be the earliest-affected neural region and autonomic symptoms may precede the classical symptoms of these disorders.

Methods: The major advantages of skin biopsy as an in vivo diagnostic tool for synucleinopathies are that it is an inexpensive and easy-to-perform technique requiring only limited facilities, and that it is repeatable in long-term studies as it causes only minor discomfort to the patient. Read More

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November 2018

Endoscopic therapy for confirmed low-grade dysplasia in Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 29;3:83. Epub 2018 Oct 29.

Unità Operativa Complessa di Endoscopia Digestiva Chirurgica, Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche Istituto di Clinica Chirurgica Generale e Terapia Chirurgica Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Roma, Italia.

Barrett's esophagus (BE) is a premalignant condition characterized by replacement of the esophageal lining with metastatic columnar epithelium. To date, the management in case of confirmed low-grade dysplasia (LGD) remains controversial. In this article we summarize the available endoscopic options and their results in terms of efficacy and safety in the treatment of confirmed LGD in BE. Read More

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October 2018
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Arthroscopic Superior Capsular Reconstruction With a Minimally Invasive Harvested Fascia Lata Autograft Produces Good Clinical Results.

Orthop J Sports Med 2018 Nov 27;6(11):2325967118808242. Epub 2018 Nov 27.

Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento, Lisbon, Portugal.

Background: Painful dysfunctional shoulders with irreparable rotator cuff tears (IRCTs) in active patients are a challenge. Arthroscopic superior capsular reconstruction (ASCR) is a new treatment option originally described using a fascia lata autograft harvested through an open approach. However, concerns about donor site morbidity have discouraged surgeons from using this type of graft. Read More

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November 2018

Human Extraparenchymal Neurocysticercosis: The Control of Inflammation Favors the Host…but Also the Parasite.

Front Immunol 2018 16;9:2652. Epub 2018 Nov 16.

Unidad de Neuroinflamación, Instituto de Investigaciones Biomédicas, UNAM/ Facultad de Medicina UNAM / Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, Mexico.

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November 2018

Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma.

Front Immunol 2018 16;9:2431. Epub 2018 Nov 16.

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czechia.

The treatment of cancer, especially of various types of solid tumors, has been revolutionized by the blockade of the PD-1/PD-L1 pathway by immune checkpoint inhibitors. Their success amongst hematologic malignancies, however, has been limited so far to the treatment of classic Hodgkin's lymphoma, which portrays a typical overexpression of PD-1 ligands (PD-L1, PD-L2) as a consequence of changes in chromosome 9p24.1. Read More

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November 2018
1 Read

Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects.

Sci Rep 2018 Nov 30;8(1):17518. Epub 2018 Nov 30.

Unidad de Gestión Clínica Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Málaga, Spain.

Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. Read More

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November 2018

[Horner's syndrome as presentation of pulmonary tuberculosis].

Medicina (B Aires) 2018 ;78(6):447-448

Servicio de Medicina Interna, Clínica Universitaria Reina Fabiola, Córdoba, Argentina.

Horner's syndrome results from a blockage of the sympathetic innervation to the eye at any point along its trajectory. It presents various etiologies, and it is a very unusual form of presentation of pulmonary tuberculosis. We describe the case of a patient with a Horner syndrome secondary to involvement of the pulmonary apex due to tuberculosis. Read More

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January 2018

[Obstructive sleep apnea-hypopnea and stroke].

Medicina (B Aires) 2018 ;78(6):427-435

Departamento de Medicina, Universitat Autónoma de Barcelona, Barcelona, España.

Stroke, one of the main causes of disability and death worldwide, is frequently associated to the obstructive sleep apnea-hypopnea syndrome. This sleep disorder has been demonstrated to be an independent risk factor for stroke, and therefore its investigation and treatment has been recommended for patients with stroke. Mechanisms relating these two clinical disorders include: oxidative stress, cerebral blood flow alterations, autonomic dysfunction, and hypercoagulability, as well as patent foramen ovale, blood pressure, and heart rhythm disorders. Read More

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January 2018

[Approach to patients with vertigo].

Medicina (B Aires) 2018 ;78(6):410-416

Servicio de Otorrinolaringología, Hospital Británico de Buenos Aires, Argentina.

Vertigo is defined as an abnormal sensation of body motion or of its surrounding objects. It is a common chief complaint in emergency departments comprising 2 to 3% of these consultations worldwide. Vertigo is classified as peripheral or central, according to its origin, and can also be occasionally mixed, the most common cause of peripheral involvement being benign paroxysmal positional vertigo. Read More

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January 2018
4 Reads

[Bone seeking tracers' scintigraphy for the diagnosis of transthyretin cardiac amyloidosis].

Medicina (B Aires) 2018 ;78(6):395-398

Sección Medicina Nuclear, Servicio de Diagnóstico por Imágenes, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Transthyretin cardiac amyloidosis (ATTR) is a restrictive cardiomyopathy that leads to heart failure in considerable number of patients. Early diagnosis allows specific treatment options. However, ATTR diagnosis is complex and requires invasive procedures. Read More

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January 2018

Self-reported hypersensitivity and allergy to foods amongst Mexican adolescents: Prevalence and associated factors.

Allergol Immunopathol (Madr) 2018 Nov 29. Epub 2018 Nov 29.

Universidad Autónoma del Estado de México, Centro de Investigación en Ciencias Médicas, Estado de México, Jesús Carranza No. 205, Colonia Universidad, Toluca de Lerdo, Estado de México, C.P. 50130, Mexico.

Background: The prevalence of food allergy is on the rise on a global scale.

Objective: To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences.

Methods: A cross-sectional study was carried out among 1992 adolescents (aged 15-18 years). Read More

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November 2018

Histopathological Findings in the Viscera of Malformed Neotropical Viperids.

J Comp Pathol 2018 Nov 28. Epub 2018 Nov 28.

University of São Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Laboratory of Wildlife Comparative Pathology, Av. Orlando Marques de Paiva 87, São Paulo, Brazil.

Congenital malformations (CMs) or developmental abnormalities are pathological processes defined as morphological defects that originate during embryonic stages. A wide variety of CMs is observed in reptiles, most of which are incompatible with normal life. Characterization of CMs and their pathogenesis are of great importance for the conservation of reptiles, including neotropical viperids (NVs). Read More

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November 2018

Utility of flow cytometry in canine primary cutaneous and matched nodal mast cell tumor.

Vet J 2018 Dec 12;242:15-23. Epub 2018 Oct 12.

Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, Turin, Italy. Electronic address:

Mast cell tumors (MCT) are among the most frequent tumors in dogs, but studies regarding canine mast cell immunophenotype are lacking. The aim of this study was to assess the feasibility of flow cytometric analysis of MCTs, to describe canine MCTs immunophenotype(s), and to evaluate the ability of flow cytometry to detect mast cells in lymph node aspirates. Thirty-four primary canine MCTs and 12 draining lymph nodes were evaluated regarding the expression of CD117, IgE, CD11b, CD18, CD44, CD34, CD25 and CD45. Read More

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December 2018

[Obstructive tracheobronchitis due to Aspergillus fumigatus in an immunocompetent patient].

Rev Iberoam Micol 2018 Nov 29. Epub 2018 Nov 29.

Servicio de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, España; Instituto de Investigación Biomédica de Cádiz (INiBICA), Cádiz, España.

Background: Aspergillus tracheobronchitis (ATB) is an uncommon type of invasive pulmonary aspergillosis in which fungal involvement is limited to the tracheobronchial tree. While the more severe forms, such as pseudomembranous and ulcerative ATB, occur almost exclusively in immunocompromised patients, the milder obstructive form may occur in patients without immune deficiency.

Case Report: The case of a 32 year-old man with no previous history of illness, who was evaluated for recurrent right lower lobe pneumonia, is presented. Read More

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November 2018

Correction of Trapdoor Effect Following Nasal Pyramid Reconstruction With a Transposition Flap.

Authors:
P Redondo

Actas Dermosifiliogr 2018 Nov 28. Epub 2018 Nov 28.

Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Navarra, España. Electronic address:

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November 2018

Choroideraemia: A case report.

Arch Soc Esp Oftalmol 2018 Nov 29. Epub 2018 Nov 29.

Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, España; Departamento de Cirugía, Universidad de Sevilla, Sevilla, España.

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November 2018

Lymphocyte proliferation and apoptosis of lymphocyte subpopulations in bovine leukemia virus-infected dairy cows with high and low proviral load.

Vet Immunol Immunopathol 2018 Dec 3;206:41-48. Epub 2018 Nov 3.

Laboratorio de Virología, Centro de Investigación Veterinaria de Tandil (CIVETAN, CONICET-UNCPBA-CICPBA), Facultad de Cs. Veterinarias, UNCPBA, Paraje Arroyo Seco s/n, 7000, Tandil, Argentina. Electronic address:

Bovine leukemia virus (BLV) is one of the most important virus in dairy cattle. The infection behavior follows what we call the iceberg phenomenon: 60% of infected animals do not show clinical signs; 30% develop persistent lymphocytosis (PL); and the remaining 10%, die due to lymphosarcoma. BLV transmission depends on infected cell exchange and thus, proviral load is determinant. Read More

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December 2018

Somatic Mutations in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Semin Hematol 2018 Oct 17;55(4):215-222. Epub 2018 Apr 17.

Serviço de Hematologia e Transplantação de Medula, Hospital de Santa Maria, Lisboa, Portugal.

Myeloproliferative neoplasms (MPN) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPN are characterized by clonal proliferation of myeloid progenitors leading to erythrocytosis, thrombocytosis, or leukocytosis, and risk of hemorrhagic and thrombotic events, as well as myelofibrosis and blast transformation. The discovery of somatic mutations in MPN, namely JAK2 V617F, JAK2 exon 12, MPL, and CALR mutations, has permitted a more specific approach to diagnosis and treatment. Read More

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October 2018

Factors associated with mortality in severe community-acquired pneumonia: A multicenter cohort study.

J Crit Care 2018 Nov 22;50:82-86. Epub 2018 Nov 22.

Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Postgraduate Program, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil.

Objective: Describe characteristics and outcomes of CAP admitted to public ICUs in Brazil.

Methods: Retrospective cohort study in 4 Tertiary Public Hospitals in Rio de Janeiro, Brazil during 2016. Patients admitted to ICUs with a diagnosis of community-acquired pneumonia were included. Read More

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November 2018

Appendiceal Mucocele - Unexpected Finding in Colonoscopy.

Clin Gastroenterol Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Hospital Garcia de Orta, Gastroenterology department, Almada, Portugal; CUF Almada Clínica, Gastroenterology department, Almada, Portugal.

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November 2018
2 Reads

Ovarian Function In Adolescents Conceived By Assisted Reproductive Technologies.

J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Maternal and Child Research, School of Medicine, University of Chile.

Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).

Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.

Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More

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November 2018

Microperimetry and swept-source optical coherence tomography in the assessment of the preferred retinal locus in a child with macular retinoblastoma in the remaining eye.

J AAPOS 2018 Nov 28. Epub 2018 Nov 28.

Moorfields Eye Hospital, Moorfields NHS Trust, London, United Kingdom; Retinoblastoma Unit, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom; National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital, NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

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November 2018

Diagnostic role of tumor markers.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Dirección Regional para la Seguridad del Paciente, Consejería de Salud, Junta de Andalucía, Sevilla, España; Comisión de Seguridad del Paciente, Sociedad Española de Bioquímica Clínica y Medicina del Laboratorio, Barcelona, España.

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November 2018

Late Shoulder-Arm Morbidity Using Ultrasound Scalpel in Axillary Dissection for Breast Cancer: A Retrospective Analysis.

J Surg Res 2019 Jan 17;233:88-95. Epub 2018 Aug 17.

Dipartimento di Scienze Cardiotoraciche e Respiratorie, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italia.

Background: We aimed to assess whether the use of the harmonic scalpel (HS) in axillary dissection would reduce long-term shoulder-arm morbidity compared to traditional instruments (TIs).

Materials And Methods: A retrospective analysis on 180 patients who underwent standard axillary dissection for breast cancer between 2007 and 2015 was carried out. All patients were evaluated for postoperative pain, impairment of shoulder-arm mobility, seroma formation in axilla, frozen shoulder, and lymphedema. Read More

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January 2019

Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology.

Glob Heart 2018 Nov 27. Epub 2018 Nov 27.

Centre for Global Chronic Conditions, London School of Hygiene and Tropical Medicine, London, United Kingdom.

The burden of cardiovascular diseases (CVD) is increasing, particularly in low-middle-income countries such as most of Latin America. This region presents specific socioeconomic characteristics, generating a high incidence of CVD despite efforts to control the problem. A consensus statement has been developed by Inter-American Society of Cardiology with the aim of answering some important questions related to CVD in this region and the role of the polypill in cardiovascular (CV) prevention as an intervention to address these issues. Read More

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November 2018

Using a Chagas disease hospital database: a clinical and epidemiological patient profile.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):831-835

Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Introduction: Chagas disease (CD) prevention and control rely on studies of its distribution, characteristics of individuals affected and mode of transmission. CD data in Brazil are scarce; a retrospective analysis of the clinical characteristics of 80 patients treated at the Clinical Hospital of UNICAMP, Campinas, Brazil, was performed.

Methods: Patient data records were analyzed. Read More

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December 2017
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Prevalence and risk factors of toxoplasmosis among adults in a small Brazilian city.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):781-787

Departamento de Oftalmologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Introduction: The prevalence of Toxoplasma gondii infection varies markedly among different populations, especially depending on factors related to socioeconomic development and eating habits. Cássia dos Coqueiros is a small city in Brazil with rural characteristics and increased risk factors traditionally associated with T. gondii infection. Read More

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May 2018
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Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):769-780

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Rio de Janeiro, RJ, Brasil.

Introduction: Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations.

Methods: A retrospective review of medical records was conducted to compare the therapeutic response to 5 mg Sbv/kg/day MA treatment among 36 patients who acquired ATL in Brazilian states other than Rio de Janeiro (OS group) and 72 patients from Rio de Janeiro (RJ group).

Results: One course of 5 mg Sbv/kg/day MA cured 72. Read More

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December 2017
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Quality of life predictors for people living with HIV/AIDS in an impoverished region of Brazil.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):743-751

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Quality of life (QoL) is important for people living with HIV/AIDS, particularly as the disease progresses. This study evaluated the QoL of people living with HIV/AIDS (PLWHA), as well as its predictors, in one of the most impoverished regions of Brazil.

Methods: This cross-sectional study was conducted with patients older than 18 years with HIV/AIDS from two specialized HIV/AIDS care centers in the city of Montes Claros between 2013 and 2014. Read More

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December 2017
3 Reads