61,463 results match your criteria Clinica Chimica Acta [Journal]


Nutrition and its role in human evolution.

J Intern Med 2019 Feb 17. Epub 2019 Feb 17.

Vice Chancellor and Dean for Agriculture and Life Sciences, Texas A&M AgriLife, College Station, TX, USA.

Our understanding of human evolution has improved rapidly over recent decades, facilitated by large-scale cataloguing of genomic variability amongst both modern and archaic humans. It seems clear that the evolution of the ancestors of chimpanzees and hominins separated 7-9 million years ago with some migration out of Africa by the earlier hominins; Homo sapiens slowly emerged as climate change resulted in drier, less forested African conditions. The African populations expanded and evolved in many different conditions with slow mutation and selection rates in the human genome, but with much more rapid mutation occurring in mitochondrial DNA. Read More

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http://dx.doi.org/10.1111/joim.12878DOI Listing
February 2019

Acquired and progressive myelinated retinal nerve fibers in neurofibromatosis type 1.

J AAPOS 2019 Feb 14. Epub 2019 Feb 14.

Hospital de Santa Maria, Lisboa, Portugal; Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal .

Acquired myelinated retinal nerve fibers (MRNF) is rare. The reported cases occur after optic disk injuries. We describe a case of a patient with neurofibromatosis type 1 and bilateral optic pathway glioma, who after 3 years' follow-up developed unilateral MRNF. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.01.012DOI Listing
February 2019

Sequential administrations of trifluoroacetate induce tolerance to Palicourea maccgravii, a monofluoroacetate-containing plant, in calves.

Toxicon 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil. Electronic address:

Monofluoroacetate (MFA) is considered one of the most toxic substances known. It is found naturally in plants, and causes sudden death syndrome in ruminants. Due to hyperacute evolution of poisoning and the absence of effective treatment, induction of resistance in animals might be the best tool to control MFA poisoning in ruminants. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.02.005DOI Listing
February 2019

General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.

Parkinsonism Relat Disord 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany. Electronic address:

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.

Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.019DOI Listing
February 2019

[Use of off-label drugs in neonatal intensive care].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Epidemiología Clínica y Bioestadística, Complexo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica A Coruña (INIBIC) Sergas, A Coruña, España.

Objective: To evaluate the prevalence of non-approved prescriptions (off-label and unlicensed) in a Neonatal Intensive Care Unit (NICU), and to describe factors of the neonate associated with its use.

Materials And Methods: Observational prospective study in a level III NICU during a 6-month period. Every prescription was analysed using the summary of product characteristics as a reference. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.12.015DOI Listing
February 2019

A giant retroperitoneal liposarcoma with renal involvement: A case report and literature review.

Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Endoscopia y Departamento de Gastroenterología, Hospital CIMA Sanitas, Barcelona, España.

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http://dx.doi.org/10.1016/j.gastrohep.2019.01.003DOI Listing
February 2019

[Prevalence of dementia in the elderly in Latin America: A systematic review].

Rev Esp Geriatr Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Fundación Oftalmológica de Santander, Clínica Carlos Ardila Lulle-FOSCAL, Departamento de Medicina Interna y Geriatria, Bucaramanga, Colombia.

Background And Objective: Dementia is a growing public health problem. It involves the impairment of several cognitive functions, generating mental and physical disability, and therefore greater functional dependence. There is limited epidemiological information which reveals an approximate prevalence in older adults from Latin America. Read More

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http://dx.doi.org/10.1016/j.regg.2018.12.007DOI Listing
February 2019

Patterns of recovery course in early intervention for FIRST episode non-affective psychosis patients: The role of timing.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain.

Background: Prevention of symptom relapse and promotion of functional recovery are the two main goals of early intervention following a first episode of non-affective psychosis (FEP). The identification of patterns of recovery is important in developing and implementing recovery focused interventions at set time interval.

Method: Patterns of recovery course, in terms of symptomatic and functional remission, were explored at 1 and 3-year follow-up in a sample of 373 consecutive FEP patients. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.032DOI Listing
February 2019

Advanced magnetic resonance imaging techniques for tumors of the head and neck.

Radiologia 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Radiología, Clínica Universitaria de Navarra Campus Madrid, Madrid, España.

Magnetic resonance imaging has become a fundamental tool for the evaluation of head and neck tumors. The anatomic details that magnetic resonance images provide are fundamental for diagnosing, characterizing, and staging both primary tumors and lymph node metastases. In addition to technical improvements in anatomic sequences, such as Dixon techniques to improve fat suppression, other sequences being developed, such as diffusion and perfusion, provide molecular, biological, and physiological information about the tumor and are yielding imaging biomarkers that can help in determining the tumor's biology at the time of diagnosis and in the follow-up of the disease. Read More

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http://dx.doi.org/10.1016/j.rx.2018.12.004DOI Listing
February 2019

Integral Facial Management of the Aesthetic Patient: The Skin Age Management Protocol.

Actas Dermosifiliogr 2019 Feb 13. Epub 2019 Feb 13.

Clínica Dermatológica Internacional, Madrid, España.

Aesthetic dermatology includes many minimally invasive therapies that can help our patients age gracefully and discreetly. Because it is hard to systematize these treatments to make patients aware of the options they have for the area of the face they want to improve, at Clínica Dermatológica Internacional, we have developed the Skin Age Management (SAM) protocol. In this article, we describe the protocol, which is aimed at helping doctors and patients to better understand and plan available treatments, underlining the advisability of combining techniques with the goal of achieving discreet changes to obtain what we consider to be optimum results, based on our experience at our center. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.016DOI Listing
February 2019

A combined immunodeficiency with severe infections, inflammation and allergy caused by ARPC1B deficiency.

J Allergy Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory AMC, University of Amsterdam, The Netherlands. Electronic address:

We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.003DOI Listing
February 2019

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: Systematic Review and Meta-Analysis.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Instituto de Efectividad Clínica y Sanitaria, Centro de Investigación de Epidemiología y Salud Pública, Argentina.

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature.

Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. Read More

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http://dx.doi.org/10.1111/tmi.13217DOI Listing
February 2019

Efficacy of nintedanib and docetaxel in patients with advanced lung adenocarcinoma treated with first-line chemotherapy and second-line immunotherapy in the nintedanib NPU program.

Clin Transl Oncol 2019 Feb 15. Epub 2019 Feb 15.

M.D. Anderson Cancer Center, Madrid, Spain.

Purpose: Both nintedanib/docetaxel and anti-PD-1/PD-L1 immunotherapies have demonstrated efficacy as second-line treatment of patients with advanced lung adenocarcinoma. This is the first report on the efficacy of the nintedanib/docetaxel combination following first-line platinum-based chemotherapy and subsequent immunotherapy in a real-world setting.

Methods/patients: From May 2014 to December 2015, 390 patients in 108 Spanish centres enrolled in the nintedanib named patient use program. Read More

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http://dx.doi.org/10.1007/s12094-019-02053-7DOI Listing
February 2019

Synovial fluid leukocyte count in asymptomatic hyperuricaemia with crystal deposition: a proof-of-concept study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Sección de Reumatología, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez023DOI Listing
February 2019

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Cell Death Dis 2019 Feb 15;10(3):147. Epub 2019 Feb 15.

Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.

Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cross-linking and proteomics analyses, we characterized a Fhit protein complex involved in triggering Fhit-mediated apoptosis. The complex includes the heat-shock chaperonin pair, HSP60/10, which is likely involved in importing Fhit into the mitochondria, where it interacts with ferredoxin reductase, responsible for transferring electrons from NADPH to cytochrome P450 via ferredoxin, in electron transport chain complex III. Read More

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http://dx.doi.org/10.1038/s41419-019-1414-7DOI Listing
February 2019

Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer.

Breast Cancer Res 2019 Feb 15;21(1):25. Epub 2019 Feb 15.

Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: Although parity and age at first pregnancy are among the most known extrinsic factors that modulate breast cancer risk, their impact on the biology of subsequent breast cancer has never been explored in depth. Recent data suggest that pregnancy-induced tumor protection is different according to breast cancer subtypes, with parity and young age at first pregnancy being associated with a marked reduction in the risk of developing luminal subtype but not triple negative breast cancer. In this study, we investigated the imprint of parity and age at first pregnancy on the pattern of somatic mutations, somatic copy number alterations, transcriptomic profiles, and tumor immune microenvironment by assessing tumor-infiltrating lymphocytes (TILs) levels of subsequent breast cancer. Read More

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http://dx.doi.org/10.1186/s13058-019-1111-6DOI Listing
February 2019

High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

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http://dx.doi.org/10.1093/cid/ciz144DOI Listing
February 2019

Establishing an updated core domain set for studies in juvenile idiopathic arthritis: a report from the OMERACT 2018 JIA Workshop.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

E.M. Morgan MD, Associate Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, J.E. Munro MBBS, Associate Professor, Head of Rheumatology at the Royal Children's Hospital, Melbourne, Australia and Group Leader Arthritis research, Murdoch Children's Research Institute Melbourne Australia, J. Horonjeff, PhD, Instructor, Office of Research, Division of Rheumatology, Columbia University Medical Center, New York, NY, B. Horgan, Consumer Advocate, Consumer and Community Health Research Network, Australia, B. Shea, PhD, Clinical Investigator, Ottawa Hospital Research Institute, Adjunct Professor, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada, B.M. Feldman, MD, MSc, FRCPC, Professor Pediatrics, Medicine, Institute of Health Policy Management & Evaluation, University of Toronto, Head, Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, H. Clairman, M.Sc., Clinical Research Project Coordinator, Child Health Evaluative Sciences, Hospital for Sick Children, Toronto ON, C.O. Bingham III, MD; Professor of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD; S. Thornhill, AA, Qualitative Research Consultant, Thornhill Associates, Hermosa Beach, CA, V. Strand MD, Adjunct Clinical Professor, Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, A. Alongi, PhD Student, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, S. Magni-Manzoni, M.D. Rheumatology Division, Ospedale Pediatrico Bambino Gesù, Roma, Italy, M. A.J. van Rossum, MD PhD, Pediatric Rheumatologist/Immunologist, Amsterdam Rheumatology and Immunology Center / Reade l Emma Children's Hospital Amsterdam Medical Center, Amsterdam, R. Vesely, MD, Head of the Rheumatology, Respiratory, Gastroenterology and Immunology Office Scientific and Regulatory Management Department European Medicines Agency, London, United Kingdom J. Vojinovic, MD PhD, Professor, University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology, Serbia H.I. Brunner, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, J.G. Harris, MD, Assistant Professor, Division of Rheumatology, Children's Mercy - Kansas City, Kansas City, MO, D.B. Horton, MD, MSCE, Assistant Professor, Division of Pediatric Rheumatology, Rutgers Robert Wood Johnson Medical School, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, D.J. Lovell, MD, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, M. Mannion, MD, Assistant Professor of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, H. Rahimi, MD, Assistant Professor, Division of Rheumatology, University of Rochester, Golisano Children's Hospital, Rochester, NY; A. Ravelli, MD, Professor of Pediatrics, Università degli Studi di Genova and IRCCS Istituto Giannina Gaslini, Genoa, Italy, S. Ringold, MD, Assistant Professor, Division of Rheumatology, Seattle Children's, Seattle, WA, Nicolino Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, M.S. Schrandt, J.D., Director, Patient Engagement, Arthritis Foundation, Atlanta, GA, S. Shenoi, MBBS, MS Associate Professor, Seattle Children's Hospital, Seattle, WA Natalie J. Shiff, MD, University of Florida, Shands Children's Hospital, Gainesville, FL, K. Toupin-April, PhD, Associate Scientist, Children's Hospital of Eastern Ontario Research Institute, Assistant Professor, Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada, N. Tzaribachev, MD, Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, P. Weiss, MD, MSCE, Associate Professor, Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, A. Consolaro, MD, PhD, Assistant Professor, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, Address correspondence to: E.M. Morgan MD, Associate Professor of Pediatrics, Division of Rheumatology Cincinnati Children's Hospital Medical Center 3333 Burnet Ave, MLC 4010, Cincinnati, OH 45229; Email:

Objective: The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCTs) and longitudinal observational studies (LOS) was developed without input of patients/parents. At OMERACT 2016, a special interest group voted to reconsider the core set incorporating broader stakeholder input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting. Read More

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http://dx.doi.org/10.3899/jrheum.181088DOI Listing
February 2019

Bacteremia caused by Herbaspirillum huttiense in a newborn.

Enferm Infecc Microbiol Clin 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología y Parasitología Clínica, Hospital Universitario La Paz, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2018.12.011DOI Listing
February 2019

Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Laboratorio de Lípidos y Aterosclerosis, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina.

Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adipose tissue expansion, liver fibrosis, and atherosclerotic plaque development and vulnerability. Read More

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http://dx.doi.org/10.3390/cells8020158DOI Listing
February 2019

Semaglutide as a promising antiobesity drug.

Obes Rev 2019 Feb 15. Epub 2019 Feb 15.

School of Medicine, University of Ioannina, Ioannina, Greece.

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a long elimination half-life, allowing subcutaneous (sc) administration once per week. Both the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) recently approved once-weekly sc semaglutide for the treatment of type 2 diabetes mellitus (T2DM). The weight loss efficacy of once-weekly sc semaglutide appears to be superior compared with the other once-weekly GLP-1 RAs in patients with T2DM. Read More

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http://dx.doi.org/10.1111/obr.12839DOI Listing
February 2019

Transfixion technique for the treatment of silicone oil pupillary block glaucoma refractory to Nd-YAG iridotomy.

Cir Cir 2019 ;87(2):215-218

Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

Background: Pupillary block induced by silicon oil in vitrectomized patients is a common condition usually treated with Nd-YAG laser iridotomy or with surgical removal of silicon oil.

Case Report: A case of silicone oil pupillary block glaucoma successfully treated with a 30 G needle transfixion technique is described. We performed a non-complicated vitrectomy surgery for retinal detachment with proliferative vitreoretinopathy that included lensectomy, inferior peripheral iridectomy, and silicone oil injection. Read More

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http://www.cirugiaycirujanos.com/frame_esp.php?id=130
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http://dx.doi.org/10.24875/CIRU.18000386DOI Listing
January 2019
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Application of the Kiewiet-Van Ruler model to predict the need for relaparotomy in patients with secondary peritonitis.

Cir Cir 2019 ;87(2):158-163

Clínica de Sepsis Abdominal, Departamento de Cirugía General. Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

Introduction: It is crucial the timely detection of a new infection or the persistence of it to improve the survival rates, there is no index that can determine the need for relaparotomy.

Objective: To evaluate the diagnostic certainty of the model elaborated by Kiewiet-Van Ruler.

Method: A retrospective, descriptive, cross-sectional study, patients diagnosed with abdominal sepsis who underwent exploratory laparotomy between January 2013 to and May 2015. Read More

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http://dx.doi.org/10.24875/CIRU.18000284DOI Listing
January 2019

Inflammatory biomarkers, depressive symptoms and falls among the elderly in Panama.

Curr Aging Sci 2019 Feb 15. Epub 2019 Feb 15.

Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber. Panama.

Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.

Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.

Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. Read More

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http://dx.doi.org/10.2174/1874609812666190215125104DOI Listing
February 2019

Safety and Efficacy of Polymer-Free Drug-Eluting Stents.

Circ Cardiovasc Interv 2019 Feb;12(2):e007311

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (M.C., C.A.P., G.G.S.).

Background Polymer-free drug-eluting stents are based on different technologies for drug binding and release without the use of polymer coatings. It is unknown whether different polymer-free drug-eluting stents are comparable in terms of safety and efficacy profiles. Methods and Results Polymer-free BioFreedom biolimus-eluting stents (BES) and polymer-free Cre8 amphilimus-eluting stents (AES) were investigated in 2 recent multicenter registries including 2320 all-comer patients undergoing percutaneous coronary interventions at 22 Italian centers. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007311DOI Listing
February 2019

Simultaneous occurrence of peri-mitral flutter using an epicardial connection and pulmonary vein trigger driving atrial fibrillation in the posterior wall of the left atrium.

J Cardiovasc Electrophysiol 2019 Feb 14. Epub 2019 Feb 14.

Clinica Montevergine, Mercogliano (AV), Italy.

It is not unusual to find areas of organized atrial activity in the left atrium during atrial fibrillation but when it happens these rhythms are mostly interrelated. Our report shows that extensive ablation can dissociate different portions of the same chamber to the point that simultaneous occurring atrial flutter and atrial fibrillation can be studied and terminated independently from each other This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/jce.13877DOI Listing
February 2019

Post-traumatic lymphedema treatment with superficial circumflex iliac artery perforator lymphatic free flap: A case report.

Microsurgery 2019 Feb 15. Epub 2019 Feb 15.

Department of Plastic Surgery and Burns, Hospital del Trabajador, Santiago, Chile.

Post-traumatic lymphedema is poorly understood. It is rarely considered in limb reconstruction decision-making approach. We report a case of a 41-year-old female who presented with right upper extremity lymphedema after degloving injury and split thickness skin graft, successfully treated with a superficial circumflex iliac artery perforator (SCIP) free flap restoring the lymphatic drainage. Read More

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http://dx.doi.org/10.1002/micr.30437DOI Listing
February 2019

Critical Care Aspects of Gallstone Disease.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):6-18. Epub 2019 Feb 4.

Department of Medicine, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, "Albert Einstein" College of Medicine, Bronx, NY 10461, USA.

Approximately twenty per cent of adults have gallstones making it one of the most prevalent gastrointestinal diseases in Western countries. About twenty per cent of gallstone patients requires medical, endoscopic, or surgical therapies such as cholecystectomy due to the onset of gallstone-related symptoms or gallstone-related complications. Thus, patients with symptomatic, uncomplicated or complicated gallstones, regardless of the type of stones, represent one of the largest patient categories admitted to European hospitals. Read More

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http://dx.doi.org/10.2478/jccm-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369569PMC
January 2019

Epiretinal Membrane Surgery in Daily Clinical Practice: Results of a Proposed Management Scheme.

J Ophthalmol 2019 10;2019:8246858. Epub 2019 Jan 10.

Clínica Rementería, Madrid, Spain.

Purpose: To report the results of the epiretinal membrane (ERM) management guidelines followed in our center.

Methods: Patients with ERM seen between 2014 and 2015, with ≥2 years follow-up or who had undergone ERM surgery, were included. Corrected visual acuity (VA), lens status, and ERM configuration were recorded at each visit. Read More

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http://dx.doi.org/10.1155/2019/8246858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350604PMC
January 2019

International radical trachelectomy assessment: IRTA study.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000273DOI Listing
February 2019

[Quality of life of parents of school age children with a birth weight less than 1500 grams].

An Pediatr (Barc) 2019 Feb 11. Epub 2019 Feb 11.

Facultad de Psicología, Instituto de Neurociencias del Principado de Asturias (INEUROPA), Universidad de Oviedo, Oviedo, España.

Introduction: The birth of a preterm child has a high family emotional cost. The aim of this study is to assess the quality of life of parents of children aged 5-7 years born prematurely (<1500g).

Participants And Methods: This is a cross-sectional study of a sample of parents of preterm infants admitted to a third level hospital in Spain between 2009 and 2011. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.10.013DOI Listing
February 2019

[Clinical validation of 2 morbidity groups in the primary care setting].

Aten Primaria 2019 Feb 11. Epub 2019 Feb 11.

Coordinador general de las tecnologías de la información y comunicación, Departamento de Salud de la Generalidad de Cataluña, Barcelona, España.

Introduction: Adjusted Morbidity Groups (GMAs) and the Clinical Risk Groups (CRGs) are population morbidity based stratification tools which classify patients into mutually exclusive categories.

Objetive: To compare the stratification provided by the GMAs, CRGs and that carried out by the evaluators according to the levels of complexity.

Design: Random sample stratified by morbidity risk. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.09.016DOI Listing
February 2019

Clinical results of pulsed signal therapy on patellofemoral syndrome with patellar chondropathy.

Bioelectromagnetics 2019 Feb 14. Epub 2019 Feb 14.

Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

This study was designed to evaluate the effect of pulsed signal therapy (PST) on patellofemoral pain syndrome associated with patellar chondropathy. A prospective randomized double-blind placebo controlled trial included 25 patients (41 knees) between 20 and 50 years with pain due to isolated patellofemoral syndrome with chondropathy. PST group received nine 60-min daily sessions of PST treatment. Read More

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http://dx.doi.org/10.1002/bem.22172DOI Listing
February 2019

Renal and Vascular Effects of Kallikrein Inhibition in a Model of Lonomia obliqua Venom-Induced Acute Kidney Injury.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007197. Epub 2019 Feb 14.

Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), Porto Alegre, RS, Brazil.

Background: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007197DOI Listing
February 2019

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

A Maia, INTERNAL MEDICINE, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, Porto Alegre, 90035-003, Brazil.

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. Read More

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http://dx.doi.org/10.1530/EC-18-0506DOI Listing
February 2019

Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic -infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0982DOI Listing
February 2019

Clinical applications of microenvironment-controlled immunosuppressive properties of mesenchymal stem cells-derived exosomes: a review.

J Biol Regul Homeost Agents 2018 Jul-Aug;32(4 Suppl. 1):15-20

Dipartimento di Area Medica, Università degli Studi di Udine, Udine, Italy.

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February 2019

Effect of the catechol-O-methyltransferase Val Met polymorphism on theory of mind in obesity.

Eur Eat Disord Rev 2019 Feb 13. Epub 2019 Feb 13.

Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain.

Obesity is often accompanied with psychosocial adjustment problems, such as difficulties in social interactions and social withdrawal. A key aspect of social cognition is theory of mind, which allows inferring mental states, feelings, motivations, and beliefs of others and to use this information to predict their future behaviour. Theory of mind is highly dependent on prefrontal dopaminergic neurotransmission, which is regulated by catechol-O-methyltransferase (COMT) activity. Read More

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http://dx.doi.org/10.1002/erv.2665DOI Listing
February 2019

Neutrophils Which Migrate to Lymph Nodes Modulate CD4 T Cell Response by a PD-L1 Dependent Mechanism.

Front Immunol 2019 29;10:105. Epub 2019 Jan 29.

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

It is well known that neutrophils are rapidly recruited to a site of injury or infection and perform a critical role in pathogen clearance and inflammation. However, they are also able to interact with and regulate innate and adaptive immune cells and some stimuli induce the migration of neutrophils to lymph nodes (LNs). Previously, we demonstrated that the immune complex (IC) generated by injecting OVA into the footpad of OVA/CFA immunized mice induced the migration of OVA neutrophils to draining LNs (dLNs). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362305PMC
January 2019

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.

Front Immunol 2019 29;10:80. Epub 2019 Jan 29.

Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Innate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson's disease (PD) and may contribute to the pathophysiology of the disease. The discovery of misfolded alpha-synuclein (αSYN) protein aggregates, which amplify in a "prion-like" fashion, has led us to consider that pathogenic αSYN might be hijacking the activation and mobilization mechanism of the peripheral immune system to reach and disseminate within the CNS. Furthermore, our lab and other groups have recently shown that αSYN can adopt distinct fibril conformations or "strains" with varying levels of pathogenic impact. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361759PMC
January 2019

Quality of Life in Brain Cancer: Clinical Validation of the Mexican-Spanish Version of the EORTC QLQ-BN20 Questionnaire.

Front Neurol 2019 30;10:40. Epub 2019 Jan 30.

Subdirección de Investigación Clínica, Instituto Nacional de Cancerología, Mexico City, Mexico.

Overall survival (OS) of patients with Brain Cancer (BC) is slowly increasing. The disease itself and its treatments deeply impact patient Health-related quality of life (HRQL). Therefore, valid and reliable instruments are needed. Read More

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http://dx.doi.org/10.3389/fneur.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363944PMC
January 2019

Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis.

Front Neurol 2019 29;10:30. Epub 2019 Jan 29.

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy.

Disease course of multiple sclerosis (MS) is negatively influenced by proinflammatory molecules released by activated T and B lymphocytes and local immune cells. The endovanilloid system plays different physiological functions, and preclinical data suggest that transient receptor potential vanilloid type 1 (TRPV1) could modulate neuroinflammation in this disorder. The effect of TRPV1 activation on the release of two main proinflammatory cytokines, tumor necrosis factor (TNF) and interleukin (IL)-6, was explored in activated microglial cells. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00030
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http://dx.doi.org/10.3389/fneur.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361812PMC
January 2019
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Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease.

Front Cell Neurosci 2019 29;13. Epub 2019 Jan 29.

Departamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CNS. The latter requires a fine coordinated intercellular communication with neurons and other glial cell types, including astrocytes. Read More

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http://dx.doi.org/10.3389/fncel.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361860PMC
January 2019

One-Year Clinical Outcomes of the Legflow Drug-Coated Balloon for the Treatment of Femoropopliteal Occlusions Registry.

J Endovasc Ther 2019 Feb;26(1):26-30

1 Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.

Purpose: To report the 1-year outcomes of the prospective Legflow drug-coated balloon (DCB) registry, which evaluated the safety and 12-month efficacy of the Legflow balloon in the treatment of femoropopliteal disease.

Methods: The Legflow is a new generation of DCB that has a homogenous, stable surface coating incorporating 0.1-µm paclitaxel particles. Read More

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http://dx.doi.org/10.1177/1526602818823557DOI Listing
February 2019

Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.

J Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory Medicine Unit, Department of Medicine, University of Padova, Padua, Italy.

Background And Aims: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00595-1DOI Listing
February 2019

Atrial high rate episodes in patients with cardiac implantable electronic devices: implications for clinical outcomes.

Clin Res Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

Background: Atrial high rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are associated with an increased risk of stroke. However, the impact of AHRE on improving stroke risk stratification scheme remains uncertain.

Objective: The purpose of this study was to assess the impact of AHRE on prognosis in relation with cardiovascular events and risk stratification. Read More

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http://dx.doi.org/10.1007/s00392-019-01432-yDOI Listing
February 2019

Metastatic seeding after a stereotactically-guided biopsy followed by gamma knife surgery.

Arq Neuropsiquiatr 2019 Jan;77(1):64

Hospital-Clínica Kennedy, Department of Neurological Sciences, Guayaquil, Ecuador.

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http://dx.doi.org/10.1590/0004-282X20180136DOI Listing
January 2019