1,879 results match your criteria Climacteric[Journal]


Conflicts of interest and the ICMJE disclosure form.

Authors:
James H Pickar

Climacteric 2019 Mar 25:1-2. Epub 2019 Mar 25.

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http://dx.doi.org/10.1080/13697137.2019.1589837DOI Listing

Women and diabetes: disparity in treatment.

Climacteric 2019 Mar 25. Epub 2019 Mar 25.

a Department of Surgical, Medical and Dental Department of Morphological Sciences related to Transplant , Oncology and Regenerative Medicine, University of Modena and Reggio Emilia , Modena , Italy.

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http://dx.doi.org/10.1080/13697137.2019.1588243DOI Listing

Diagnosis of endometriosis in the 21st century.

Authors:
L Kiesel M Sourouni

Climacteric 2019 Mar 25:1-7. Epub 2019 Mar 25.

a Department of Gynecology and Obstetrics , University Hospital of Münster , Münster , Germany.

Endometriosis is a common disease but, due to the wide spectrum of symptoms, diagnosis can be delayed 8-12 years. Laparoscopy is nowadays the gold standard for diagnosis. A less invasive method could shorten the time to diagnosis. Read More

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http://dx.doi.org/10.1080/13697137.2019.1578743DOI Listing
March 2019
1 Read

Safety of hormone replacement therapy following risk-reducing salpingo-oophorectomy: systematic review of literature and guidelines.

Climacteric 2019 Mar 25:1-9. Epub 2019 Mar 25.

a Department of Gynecology , The Netherlands Cancer Institute , Amsterdam , the Netherlands.

Background: Women at high risk to develop ovarian cancer opt for risk-reducing salpingo-oophorectomy (RRSO) to reduce the risk by 80-96%. RRSO leads to a direct onset of menopause in premenopausal women. Hormone replacement therapy (HRT) can be used to mitigate menopausal symptoms after RRSO. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1582622DOI Listing
March 2019
3 Reads

A comparison of three outcome measures of the impact of vasomotor symptoms on women's lives.

Climacteric 2019 Mar 25:1-5. Epub 2019 Mar 25.

c Department of Nursing , Swansea University , Swansea , UK.

Objective: Measures of the impact of vasomotor symptoms (VMS) have been used as outcomes in clinical trials but have not been compared. This study compares the Hot Flush Rating Scale (HFRS), the Hot Flash Related Daily Interference Scale (HFRDIS), and the shorter Hot Flash Interference (HFI) scale.

Methods: Baseline data were taken from two studies including healthy women (menopause transition or postmenopause) and breast cancer patients experiencing VMS. Read More

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http://dx.doi.org/10.1080/13697137.2019.1580258DOI Listing
March 2019
3 Reads

Sexuality in premature ovarian insufficiency.

Climacteric 2019 Mar 22:1-7. Epub 2019 Mar 22.

a Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Obstetrics and Gynecology Unit, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences , University of Pavia , Pavia , Italy.

Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Read More

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http://dx.doi.org/10.1080/13697137.2019.1575356DOI Listing
March 2019
6 Reads

Factors associated with long-term pessary use in women with symptomatic pelvic organ prolapse.

Climacteric 2019 Mar 21:1-5. Epub 2019 Mar 21.

a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China.

Objectives: This study aimed to evaluate the continuation rate and identify the factors associated with long-term pessary use, which are essential for counseling women with symptomatic pelvic organ prolapse (POP) seeking long-term pessary treatment.

Methods: This prospective observational study included 277 patients who had successful pessary fittings between April 2015 and November 2016. All patients were followed until April 2018. Read More

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http://dx.doi.org/10.1080/13697137.2019.1582623DOI Listing
March 2019
1 Read

Bone health in women with breast cancer.

Climacteric 2019 Mar 21:1-7. Epub 2019 Mar 21.

a Department of Endocrinology , Austin Health , Heidelberg , VIC , Australia.

Women with early, estrogen receptor-positive breast cancer are treated with adjuvant endocrine therapy, using aromatase inhibitors or selective estradiol receptor modulators such as tamoxifen, to deprive breast tissue from the deleterious effects of estradiol action, hence improving long-term prognosis. Aromatase inhibitors and, in premenopausal women, tamoxifen accelerate bone loss and increase fracture risk. Therefore, all women commencing endocrine therapy need a targeted work-up to assess the baseline fracture risk, and monitoring of bone health during endocrine therapy should be individualized based on this baseline risk. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1580257DOI Listing
March 2019
10 Reads

Beyond estrogen: advances in tissue selective estrogen complexes and selective estrogen receptor modulators.

Climacteric 2019 Apr;22(2):140-147

a Department of Obstetrics and Gynecology, Division of Midlife Health , University of Virginia Health System , Charlottesville , VA , USA.

Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have variable estrogen agonist and antagonist activities in different target tissues. Tamoxifen is an anti-estrogen in the breast used for treatment and prevention of breast cancer, with estrogen agonist activity in the uterus. Raloxifene prevents and treats osteoporosis and prevents breast cancer, and can be safely combined with vaginal but not systemic estrogen. Read More

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http://dx.doi.org/10.1080/13697137.2019.1568403DOI Listing
April 2019
3 Reads

Publishing in Climacteric.

Authors:
James H Pickar

Climacteric 2019 Apr;22(2):109-110

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http://dx.doi.org/10.1080/13697137.2019.1560925DOI Listing

The association between sexual dysfunction and metabolic syndrome among Turkish postmenopausal women.

Climacteric 2019 Mar 20:1-6. Epub 2019 Mar 20.

c Department of Obstetrics and Gynaecology , Maltepe University Hospital , Istanbul , Turkey.

Objective: The aim of this study is to determine the association between sexual dysfunction and metabolic syndrome (MS) among Turkish postmenopausal women Methods: In total, 290 postmenopausal women between the ages of 50 and 70 years and 265 premenopausal women between the ages of 30 and 49 years who applied to Menopause and Gynecology Clinics at Marmara University-affiliated Pendik Education and Research Hospital, Istanbul, Turkey were included in this prospective survey. Sexual function was assessed using the Female Sexual Function Index (FSFI). A FSFI total score of <26. Read More

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http://dx.doi.org/10.1080/13697137.2019.1580256DOI Listing
March 2019
2 Reads

Identification of functional estrogen response elements in glycerol channel Aquaporin-7 gene.

Climacteric 2019 Mar 19:1-6. Epub 2019 Mar 19.

a Department of Reproductive Endocrinology , Zhejiang Provincial People's Hospital, Hangzhou Medical College , Hangzhou , Zhejiang , P.R. China.

Objective: We previously reported that tissue-specific effects of estrogen on Aquaporin-7 (AQP7) expression are associated with the development of menopausal obesity. The current study was designed to identify the estrogen response elements (EREs) in the promoter of Aqp7 and investigate the role of AQP7 in the regulation of estrogen-induced anti-adipogenesis.

Methods: We measured AQP7 expression and intracellular fat accumulation in 3T3-L1 adipocytes either silenced with shRNA or treated with estrogen receptor (ER)-specific antagonists or agonists before exposure to estrogen. Read More

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http://dx.doi.org/10.1080/13697137.2019.1580255DOI Listing

PGRMC1 can trigger estrogen-dependent proliferation of breast cancer cells: estradiol vs. equilin vs. ethinylestradiol.

Climacteric 2019 Mar 12:1-6. Epub 2019 Mar 12.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: Previous studies have shown that progesterone receptor membrane component 1 (PGRMC1) expressed in breast cancer tissue can predict a worse prognosis for breast cancer patients. Moreover, we demonstrated that PGRMC1 can increase the proliferation of progestogens. However, the role of PGRMC1 in terms of estrogen-induced proliferation and comparing different estrogens is still unclear. Read More

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http://dx.doi.org/10.1080/13697137.2019.1582624DOI Listing
March 2019
5 Reads

TX-004HR clinically improves symptoms of vulvar and vaginal atrophy in postmenopausal women.

Climacteric 2019 Mar 12:1-7. Epub 2019 Mar 12.

e TherapeuticsMD , Boca Raton , FL , USA.

Objective: This study aimed to evaluate improvement of dyspareunia and associated vaginal dryness with a 17β-estradiol softgel vaginal insert (TX-004HR; TherapeuticsMD, Boca Raton, FL, USA) in women with postmenopausal vulvar and vaginal atrophy (VVA).

Methods: Postmenopausal women with VVA and moderate to severe dyspareunia received TX-004HR (4, 10, or 25 μg) or placebo in the 12-week, randomized, double-blind, placebo-controlled, phase 3 REJOICE trial. Post hoc analyses examined improvement levels in dyspareunia and concurrent vaginal dryness with TX-004HR and assessed the effects of patient characteristics on vaginal dryness treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1577379DOI Listing
March 2019
3 Reads

Pelvic floor dysfunction in midlife women.

Authors:
S L Johnston

Climacteric 2019 Mar 11:1-7. Epub 2019 Mar 11.

a Department of Obstetrics and Gynaecology , Queen's University , Kingston , ON , Canada.

Pelvic floor dysfunction in women includes urinary incontinence and pelvic organ prolapse. In midlife, genitourinary atrophy is commonly associated with these conditions and can practically be considered part of the overall condition. The pelvic floor tissues share a common hormone responsiveness and as such respond collectively to midlife estrogen loss. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1568402DOI Listing
March 2019
3 Reads

The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis.

Climacteric 2019 Mar 4:1-9. Epub 2019 Mar 4.

e Midwifery and Reproductive Health Research Center and Department of Midwifery and Reproductive Health, School of Nursing and Midwifery , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Objective: The aim of this study was to estimate the global prevalence of primary ovarian insufficiency (POI) and early menopause (EM).

Methods: A comprehensive literature search was performed in several databases to retrieve relevant English articles published between 1980 and 2017. To assess the methodological quality of the studies, the Newcastle-Ottawa Scale was used. Read More

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http://dx.doi.org/10.1080/13697137.2019.1574738DOI Listing
March 2019
2 Reads

What can we learn from the vaginal mesh story?

Climacteric 2019 Mar 4:1-6. Epub 2019 Mar 4.

b Immediate Past President of the International Urogynecological Association, Department of Women's Health , Middlemore Hospital , Auckland , New Zealand.

The use of vaginal mesh in prolapse surgery has created enormous controversy and unprecedented media interest; it has become the most emotive topic in urogynecology today. The US Food and Drug Administration 510(k) system allowed the proliferation of mesh products which were rapidly adopted by surgeons internationally. The importance of a firm understanding of the biomechanical properties of tissue and implants, surgical skill, patient selection, communication skills, informed consent, and high-quality research are all important lessons we can learn from the mesh story. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1575355DOI Listing
March 2019
10 Reads

Construct validity of the Menopause Rating Scale in Indonesia.

Climacteric 2019 Feb 27:1-6. Epub 2019 Feb 27.

a School of Nursing, College of Nursing , Taipei Medical University , Taipei , Taiwan.

Objective: This study assessed the construct validity of the Menopause Rating Scale (MRS) in Indonesia.

Methods: The study included 240 women aged over 45 years in Indonesia. The MRS measures psychological, somatic-vegetative, and urogenital symptoms using 11 items obtained from participants' daily symptom records. Read More

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http://dx.doi.org/10.1080/13697137.2019.1574737DOI Listing
February 2019
1 Read

Women's rights in Asia and elsewhere - a fact or an illusion?

Authors:
D Shah

Climacteric 2019 Feb 27:1-6. Epub 2019 Feb 27.

a Gynaecworld , Mumbai , India.

More than one-third of the world's population resides in Asia. China and India have the largest population densities and the focus of this article is on these two countries. In the seventeenth century, women were globally treated as inferior and subordinate to men. Read More

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http://dx.doi.org/10.1080/13697137.2019.1574739DOI Listing
February 2019
1 Read

Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women.

Climacteric 2019 Feb 27:1-6. Epub 2019 Feb 27.

a Menopause Research Unit, Reproductive Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Objective: This study aimed to study the efficacy and safety of estrogen plus low-dose testosterone gel in improving sexual function in postmenopausal women.

Methods: A double-blind, randomized, active-controlled trial was conducted. Seventy postmenopausal women with low sexual function were randomized into two groups. Read More

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http://dx.doi.org/10.1080/13697137.2019.1577378DOI Listing
February 2019
2 Reads

Getting it right: translating research into better health outcomes.

Authors:
Rod Baber

Climacteric 2018 Dec;21(6):517-518

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http://dx.doi.org/10.1080/13697137.2018.1545499DOI Listing
December 2018
2 Reads

SCD1 methylation in subcutaneous adipose tissue associated with menopausal age.

Climacteric 2019 Feb 19:1-8. Epub 2019 Feb 19.

a Department of Obstetrics and Gynecology , Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital) , Hangzhou , China.

Objective: This study was designed to investigate associations between menopausal age and the DNA methylation levels of stearoyl-coenzyme A desaturase 1 (SCD1, selected by the Illumina Human Methylation 450 K Bead Chip) and explore the changes in mRNA levels of SCD1 and DNA methyltransferases (DNMTs) in response to estrogen replacement therapy (ERT).

Methods: In the human experiment, we performed subcutaneous adipose tissue DNA extraction on 85 menopausal women. Methylation of SCD1 was measured by MethyLight polymerase chain reaction. Read More

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http://dx.doi.org/10.1080/13697137.2019.1571028DOI Listing
February 2019
3 Reads

Current treatments for female primary stress urinary incontinence.

Climacteric 2019 Feb 18:1-7. Epub 2019 Feb 18.

a Department of Obstetrics and Gynaecology, Helsinki University Hospital , Helsinki University , Helsinki , Finland.

Stress urinary incontinence (SUI) affects millions of women worldwide. Pelvic floor muscle training is the first-line treatment for SUI, and if this fails, midurethral sling surgery has become the gold-standard treatment. More recently, complications from midurethral mesh slings, particularly chronic pain and dyspareunia, have become a major concern. Read More

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http://dx.doi.org/10.1080/13697137.2019.1568404DOI Listing
February 2019
4 Reads

On the human condition.

Authors:
Rod Baber

Climacteric 2019 Feb;22(1):1-2

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http://dx.doi.org/10.1080/13697137.2019.1558875DOI Listing
February 2019
2 Reads

Advances in surgical strategies for prolapse.

Climacteric 2019 Feb;22(1):60-64

a Division of Obstetrics and Gynecology, Department of Experimental and Clinical Medicine , University of Pisa , Pisa , Italy.

Pelvic floor dysfunctions are a complex condition in elderly women; pelvic organ prolapse, urinary or fecal incontinence, constipation, pelvic pain, and sexual dysfunction are common problems. The goal of surgical treatment is functional reconstruction with symptom management and repair of anatomic defects. The recent advancements in surgical treatment of pelvic floor dysfunction allow several good options for choosing the best surgery for each patient. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543266DOI Listing
February 2019
9 Reads

Uterine transplantation.

Authors:
V Gomel

Climacteric 2019 Apr 4;22(2):117-121. Epub 2019 Feb 4.

a Department of Obstetrics & Gynecology , University of British Columbia , Vancouver , BC , Canada.

Successful human uterine transplantation followed by subsequent pregnancy and live birth in a woman for whom this would otherwise have been impossible is a laudable goal. Research programs have been developed in several countries aimed at achieving this goal. The pioneering Swedish program has reported live births in six women, two of whom had a second pregnancy and birth. Read More

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http://dx.doi.org/10.1080/13697137.2018.1564271DOI Listing
April 2019
7 Reads

Hierarchical measurement structure in the Women's Health Questionnaire: a confirmatory factor analysis.

Climacteric 2019 Feb 4:1-6. Epub 2019 Feb 4.

c Medicine Department , University of Southern California , Los Angeles , CA , USA.

Purpose: This study conducted confirmatory factor analysis (CFA) to examine the measurement structure of the Women's Health Questionnaire (WHQ) and how its components were organized.

Methods: Participants were 448 postmenopausal women, with a mean age of 63.3 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1564270DOI Listing
February 2019
1 Read

Metabolic syndrome during female midlife: what are the risks?

Climacteric 2019 Apr 4;22(2):127-132. Epub 2019 Feb 4.

b Department of Obstetrics and Gynecology , University of Zaragoza Faculty of Medicine and Lozano-Blesa University Hospital , Zaragoza , Spain.

The metabolic syndrome (METS) is an entity diagnosed by three or more of the following factors: abdominal obesity, low high-density lipoprotein cholesterol, and high serum triglycerides, fasting glucose, and/or blood pressure levels. Abdominal obesity is the most prevalent component of the syndrome that favors insulin resistance and a proinflammatory and prothrombotic status, and the risk of developing diabetes, hypertension, and other chronic conditions. During the menopausal transition, women tend to gain weight and this has been related to an increase in the prevalence of the METS. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561666DOI Listing
April 2019
4 Reads

The evolution of the human menopause.

Climacteric 2019 Apr 4;22(2):111-116. Epub 2019 Feb 4.

b Department of Obstetrics and Gynaecology , Princess Royal Maternity Hospital , Glasgow , UK.

The females of most species die soon after ceasing to reproduce, their purpose in life being to ensure survival of their kin. Human females may live more than one-third of their lives after they cease to reproduce, a property shared by few species, one of which is Orca whales. Orcas have been extensively studied because families live together in stable units or pods and individual whales have distinctive markings, enabling them to be identified. Read More

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http://dx.doi.org/10.1080/13697137.2018.1547701DOI Listing
April 2019
8 Reads

Esmirtazapine treatment of postmenopausal vasomotor symptoms: two randomized controlled trials.

Climacteric 2019 Feb 4:1-11. Epub 2019 Feb 4.

e MSD , Munich , Germany.

Objectives: Two identical 12-week, randomized, double-blind, placebo-controlled, multi-arm, parallel-group Phase III studies (Study P012, NCT00560833; Study P013, NCT00535288) evaluated the efficacy and safety of esmirtazapine, an investigational medicine, for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women.

Methods: Participants were randomized to placebo or esmirtazapine (2.25, 4. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561664DOI Listing
February 2019
2 Reads

Do we have new preventive strategies for optimizing cardiovascular health in women?

Authors:
C A Stuenkel

Climacteric 2019 Apr 4;22(2):133-139. Epub 2019 Feb 4.

a Department of Medicine, Division of Endocrinology and Metabolism , University of California, San Diego, School of Medicine , La Jolla , CA , USA.

Over the past decades, progress in efforts to reduce cardiovascular morbidity and mortality has been achieved, although a disturbing trend for stagnation of cardiovascular mortality rates among younger women compared with those in younger men has been identified. While the menopause transition has traditionally offered an unequivocal opportunity to assess cardiovascular risk and counsel women to adopt preventive strategies, the veritable 'window of opportunity', usually applied to the concept of timing the initiation of menopausal hormone therapy, must be opened much wider to encompass younger women including those who have experienced adverse events during pregnancy, treatment for breast cancer, and premature menopause. Collaborative efforts by a number of expert medical groups provide encouragement and justification for an aggressive approach to identify and modify cardiovascular risk earlier in younger women, starting at age 20 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561665DOI Listing
April 2019
12 Reads

Rationale and design for fractional microablative CO laser versus photothermal non-ablative erbium:YAG laser for the management of genitourinary syndrome of menopause: a non-inferiority, single-blind randomized controlled trial.

Climacteric 2019 Jan 24:1-5. Epub 2019 Jan 24.

c First Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens , Athens , Greece.

Genitourinary syndrome of menopause (GSM) is a common condition affecting up to 50% of postmenopausal women and up to 70% of postmenopausal breast cancer survivors. GSM is a chronic condition with a significant impact on sexual health and quality of life. The mainstay of treatment has been with symptomatic relief using topical emollients or lubricants. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1559806DOI Listing
January 2019
4 Reads

Ovarian tissue cryopreservation for patients with premature ovary insufficiency caused by cancer treatment: optimal protocol.

Climacteric 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: Premature ovary insufficiency is frequent after chemotherapy/radiotherapy in cancer patients. Ovarian tissue (OT) cryopreservation and later retransplantation, the routine method in Europe, has recently been implemented at the first center in China. We investigated the protective effect of the antioxidant N-acetyl-l-cysteine (NAC) during the decisive freezing-thawing steps. Read More

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http://dx.doi.org/10.1080/13697137.2018.1554644DOI Listing
January 2019
2 Reads

Mediterranean diet is associated with bone mineral density and muscle mass in postmenopausal women.

Climacteric 2019 Apr 21;22(2):162-168. Epub 2019 Jan 21.

a Gynecological Endocrinology Unit, Division of Endocrinology , Hospital de Clínicas de Porto Alegre (HCPA) , Porto Alegre , Brazil.

Purpose: This study aimed to investigate the association between the Mediterranean diet (MD), body composition, and bone mineral density (BMD) in postmenopausal women.

Methods: In this cross-sectional study, 105 apparently healthy postmenopausal women aged between 45 and 65 years were included. BMD, percentage body fat, and appendicular lean mass index (ALMI, appendicular lean mass/height squared) were assessed by dual-energy X-ray absorptiometry. Read More

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http://dx.doi.org/10.1080/13697137.2018.1529747DOI Listing
April 2019
4 Reads

Cerebrovascular reactivity after cessation of menopausal hormone treatment.

Climacteric 2019 Apr 21;22(2):182-189. Epub 2019 Jan 21.

e Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester , MN , USA.

Objective: Women who are currently using menopausal hormone therapy (MHT) have higher cerebrovascular reactivity when compared with postmenopausal women who are not taking MHT; however, the effect of cessation of MHT on cerebrovascular reactivity is not known. Given that MHT can have structural and activational effects on vascular function, this study was performed to characterize cerebrovascular reactivity following cessation of MHT in women at low risk for cerebrovascular disease.

Methods: Cerebrovascular reactivity was measured in a subset of women from the Kronos Early Estrogen Prevention Study (KEEPS) 3 years after cessation of the study drug (oral conjugated equine estrogen, transdermal 17β-estradiol, or placebo [PLA]). Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1538340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428595PMC
April 2019
21 Reads

Keeping the pelvic floor healthy.

Climacteric 2019 Jan 17:1-6. Epub 2019 Jan 17.

a School of Rehabilitation, Faculty of Medicine , University of Montreal, Research Centre of the Institut Universitaire de Gériatrie de Montréal , Montreal , QC, Canada.

Female pelvic floor muscles form a diaphragm that spans the entire pelvic cavity. They consist of the fibers of the coccygeus and the levator ani muscles, the latter of which is composed of five parts. Together with their fascia, the pelvic floor muscles provide support for the urethra, the vagina, and the rectum and constrict the urethral, vaginal, and anal orifices. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1552934DOI Listing
January 2019
12 Reads

Factors related to muscle strength in postmenopausal women aged younger than 65 years with normal vitamin D status.

Climacteric 2019 Jan 17:1-5. Epub 2019 Jan 17.

b Department of Obstetrics and Gynaecology , Hospital Universitario Lozano-Blesa, University of Zaragoza Faculty of Medicine , Zaragoza , Spain.

Objective: The study aimed to determine the impact of age, age at menopause, body mass index (BMI), and lumbar and hip bone mineral density (BMD) on muscle strength in young postmenopausal women with normal vitamin D levels.

Methods: This was a cross-sectional study performed in 392 postmenopausal women aged <65 years with normal serum 25-hydroxyvitamin D levels (≥30 ng/ml) and no physical disabilities. The following variables were recorded: age, age at menopause, BMI, BMD (measured by dual-energy X-ray absorptiometry [DXA] scanning and expressed as lumbar and hip T-scores), and dominant hand grip strength (measured with a digital dynamometer). Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1554645DOI Listing
January 2019
7 Reads

Association of mindfulness and stress with menopausal symptoms in midlife women.

Climacteric 2019 Jan 17:1-6. Epub 2019 Jan 17.

a Division of General Internal Medicine, Menopause & Women's Sexual Health Clinic , Mayo Clinic , Rochester , MN , USA.

Purpose: Midlife women frequently experience stress and menopausal symptoms. Mindfulness is thought to mitigate stress by avoiding emotional reactivity and ruminative thinking. We sought to assess the association of mindfulness and stress on menopausal symptoms among midlife women. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551344DOI Listing
January 2019
14 Reads

Higher intake of dietary n-3 PUFA and lower MUFA are associated with fewer menopausal symptoms.

Climacteric 2019 Apr 10;22(2):195-201. Epub 2019 Jan 10.

a Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.

Objective: This study aimed to investigate the association between dietary fat quality and menopausal symptoms.

Methods: We carried out a cross-sectional study with 393 Iranian postmenopausal women. Dietary intakes and menopausal symptoms were assessed, using a validated food frequency questionnaire and a menopausal rating scale (MRS) questionnaire, respectively. Read More

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http://dx.doi.org/10.1080/13697137.2018.1547700DOI Listing
April 2019
1 Read

Endometriosis: seeking optimal management in women approaching menopause.

Climacteric 2019 Jan 10:1-10. Epub 2019 Jan 10.

k Department of Biomedicine and Prevention , Università degli studi di Roma 'Tor Vergata' , Rome , Italy.

The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably poor attention. Disease management is problematic for these women due to increased contraindications regarding hormonal treatment and the possibility for malignant transformation, considering the increased cancer risk in patients with a long-standing history of the disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1549213DOI Listing
January 2019
13 Reads

Hormone replacement therapy and prevention of chronic conditions.

Climacteric 2019 Jan 10:1-4. Epub 2019 Jan 10.

c Department of Obstetrics and Gynecology, Policlinico Gemelli , Rome , Italy.

Nowadays, postmenopausal women are largely undertreated. Analysis of conflicting results among different studies suggests that hormone replacement therapy (HRT) can prevent osteoporosis and cardiovascular disease in symptomatic, early postmenopausal women. In fact, climacteric symptoms are related to an increased risk of chronic conditions, including hypertension and cardiovascular disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551347DOI Listing
January 2019
9 Reads

Benefit-risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John's wort in breast cancer patients.

Climacteric 2019 Jan 10:1-9. Epub 2019 Jan 10.

e Medical Service , Schaper & Brümmer GmbH & Co. KG , Salzgitter , Germany.

Endocrine therapy in breast cancer survivors can cause severe 'climacteric' symptoms, which may compromise therapy adherence. To determine whether such symptoms can be treated with herbal medication containing black cohosh in the form of isopropanolic Cimicifuga racemosa extract (iCR) alone or in fixed combination with St John's wort (Hypericum perforatum [HP]) (iCR + HP), a systematic literature search was conducted. Results were viewed in relation to experimental data and metabolism of endocrine therapies. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551346DOI Listing
January 2019
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Association of VDR and OPG gene polymorphism with osteoporosis risk in Chinese postmenopausal women.

Climacteric 2019 Apr 9;22(2):208-212. Epub 2019 Jan 9.

a Department of Gynecology and Obstetrics , Beijing Hospital, National Center of Gerontology , Beijing , China.

Aims: The underlying mechanisms of vitamin D receptor (VDR) and osteoprotegerin (OPG) genetic variation associated with bone mineral density and osteoporosis remain uncertain. This study aimed to investigate the association of VDR and OPG gene polymorphism as well as gene-gene interaction and their haplotype combination with the risk of osteoporosis.

Methods: Polymerase chain reaction restriction fragment length polymorphism was carried out for single nucleotide polymorphism (SNP) detection. Read More

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http://dx.doi.org/10.1080/13697137.2018.1554643DOI Listing
April 2019
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Atherosclerotic disease and cardiovascular risk factors in postmenopausal breast cancer survivors: a case-control study.

Climacteric 2019 Apr 9;22(2):202-207. Epub 2019 Jan 9.

a Department of Gynecology and Obstetrics , Sao Paulo State University - UNESP , Sao Paulo , Brazil.

Objective: Breast cancer (BC) therapies and the longevity that the women achieve imply a higher cardiovascular risk. The aim of the study was to evaluate the frequency of atherosclerotic disease and its association with cardiovascular risk factors in postmenopausal breast cancer survivors (BCS) compared to postmenopausal women without BC.

Methods: In this study, 96 women with BC (case group) were compared to 192 women without BC (control group), age range 45-75 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551345DOI Listing
April 2019
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The etiology and management of recurrent urinary tract infections in postmenopausal women.

Authors:
C Jung L Brubaker

Climacteric 2019 Jan 9:1-8. Epub 2019 Jan 9.

a Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery , University of California San Diego , La Jolla , CA , USA.

Urinary tract infections (UTIs) are one of the most common infections and affect up to 50% of women in their lifetime, with almost half of these women experiencing a recurrence in 6-12 months. Menopause predisposes women to recurrent UTI (rUTI), as normally lower levels of estrogen lead to changes in the urogenital epithelium and subsequently urogenital microbiome. The recently discovered urobiome is now known to have different compositions in both healthy and unhealthy bladders, including a role in the pathophysiology of rUTI, and may be a therapeutic target for prevention and treatment options for rUTI. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551871DOI Listing
January 2019
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Assessment and hormonal management of osteoporosis.

Authors:
F Trémollieres

Climacteric 2019 Apr 9;22(2):122-126. Epub 2019 Jan 9.

a Menopause Center, Hôpital Paule de Viguier , University Hospital of Toulouse , Toulouse , France.

Postmenopausal osteoporosis is a frequent health issue in women. Because osteoporosis-related fractures cause a significant increase in mortality and morbidity, it is clinically important to identify as soon as possible women at increased risk for future fracture so that preventive measures can be instituted. At the beginning of menopause, evaluation of the subsequent risk of fracture is not so easy. Read More

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http://dx.doi.org/10.1080/13697137.2018.1555582DOI Listing
April 2019
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Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549214DOI Listing
January 2019
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Maintaining sexual function after pelvic floor surgery.

Authors:
S Jha

Climacteric 2019 Jan 7:1-6. Epub 2019 Jan 7.

a Department of Urogynaecology , Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield , UK.

Sexual dysfunction in women with prolapse and incontinence is well documented in the literature, but the impact of treatment, particularly surgical correction, remains very limited and confusing. Age, on the other hand, has been shown to be an independent risk factor for deteriorating sexual function, with all aspects of the sexual function (i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551870DOI Listing
January 2019
17 Reads

Assessment of sexual activity and menopausal symptoms in middle-aged Chinese women using the Menopause Rating Scale.

Climacteric 2019 Jan 7:1-7. Epub 2019 Jan 7.

a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Dalian Medical University , Dalian , P.R. of China.

Objectives: This study aimed to assess sexual activity and menopausal symptoms in middle-aged Chinese women and to correlate this with their vaginal maturation status (VMS).

Methods: 120 women aged 45-60 years were assigned to four groups: premenopause (Pre-M), perimenopause (Peri-M), early postmenopause (Post-EM), and late postmenopause (Post-LM). The menopausal symptoms were assessed using the Menopause Rating Scale. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1547702DOI Listing
January 2019
12 Reads