1,812 results match your criteria Climacteric[Journal]


Menopause-specific Quality of Life Questionnaire: factor and Rasch analytic approach.

Climacteric 2018 Dec 11:1-7. Epub 2018 Dec 11.

b Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

Objective: The study aimed to assess the psychometric properties of the Menopause-specific Quality of Life Questionnaire (MENQOL) in Serbian climacteric women.

Methods: Two hundred mid-aged (40-65 years) women filled out a general sociodemographic and medical questionnaire, the MENQOL, the Short Form-36 questionnaire (SF-36), and Beck's Depression Inventory (BDI). The MENQOL was translated according to recommended methodology and its psychometric properties (internal consistency, discriminant, construct and criterion validity, factor and Rasch analyses) were assessed. Read More

View Article
December 2018

Analysis of factors that influence the quality of sexual life of climacteric women in China.

Climacteric 2018 Nov 30:1-6. Epub 2018 Nov 30.

a Department of Gynecology and Obstetrics , Peking University People's Hospital , Beijing , P. R. China.

Objective: The study aimed to identify the factors associated with the sexual lives of perimenopausal and postmenopausal women in China.

Methods: A total of 426 participants were approached about this study from May 2012 to August 2013. In total, 252 cases were included in this study. Read More

View Article
November 2018
1 Read

Impact of micronized progesterone on body weight, body mass index, and glucose metabolism: a systematic review.

Climacteric 2018 Nov 27:1-14. Epub 2018 Nov 27.

a Department of Obstetrics and Gynecology , University of Bern , Bern , Switzerland.

In women, body weight increases with age. Often menopausal hormone therapy (MHT) is blamed for enhancing this effect. In recent years, the debate on bioidentical MHT including micronized progesterone (MP) has increased. Read More

View Article
November 2018
1 Read

What should guide our patient management of vulvovaginal atrophy?

Authors:
M Shapiro

Climacteric 2018 Nov 19:1-6. Epub 2018 Nov 19.

a Department of Family and Community Medicine , University of Toronto , Toronto , ON , Canada.

Genitourinary syndrome of menopause including vulvovaginal atrophy is commonly experienced by postmenopausal women, reducing their quality of life. The aim of this review is to assess current treatment options within the framework of recent management guidelines. Recommendations include use of treatments addressing both symptoms and the underlying pathophysiology, and proactive patient discussion. Read More

View Article
November 2018
3 Reads

An epidemiologic study of pelvic organ prolapse in postmenopausal women: a population-based sample in China.

Climacteric 2018 Nov 19:1-6. Epub 2018 Nov 19.

a Department of Gynecology and Obstetrics, Peking Union Medical College Hospital , Peking Union Medical College , Beijing , People's Republic of China.

Objective: This study aimed to assess the prevalence and factors associated with symptomatic pelvic organ prolapse (POP) in a representative sample of postmenopausal Chinese women.

Methods: A total of 20,008 postmenopausal Chinese women were recruited to this cross-sectional study between February 2014 and March 2016. The prevalence of symptomatic POP, defined as any stage II or higher POP resulting in symptoms, was assessed using questionnaires and physical examinations. Read More

View Article
November 2018
3 Reads

Optimizing quality of life in perimenopause: lessons from the East.

Authors:
X Wang S Ran Q Yu

Climacteric 2018 Nov 8:1-4. Epub 2018 Nov 8.

a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.

As global life expectancy improves, women are expected to spend more than one-third of their lives in the status of menopause. In China, many women suffer from menopausal symptoms during this period, which impacts their well-being and quality of life. However, most Chinese women simply endure menopausal symptoms. Read More

View Article
November 2018
2 Reads

Effects of concurrent exercise on cardiometabolic status during perimenopause: the FLAMENCO Project.

Climacteric 2018 Nov 5:1-7. Epub 2018 Nov 5.

a Department of Physiology, Faculty of Pharmacy, and Institute of Nutrition and Food Technology , University of Granada , Granada , Spain.

Objectives: The aim of this study was to evaluate the influence of a 4-month concurrent exercise training program on cardiometabolic status in perimenopausal women.

Methods: The participants (n = 150) were randomized into counseling (n = 75) and exercise (n = 75) groups. The exercise group followed 4-month (3 days/week, 60 min/session) concurrent training. Read More

View Article
November 2018
5 Reads

Sexual quality of life in men and women after cancer.

Authors:
L R Schover

Climacteric 2018 Oct 31:1-5. Epub 2018 Oct 31.

a Will2Love, LLC , Houston , TX , USA.

More than 60% of people treated for cancer have long-term sexual dysfunction. However, fewer than 25% of those with sexual problems get help from a health professional. Although cancer-related sexual problems usually begin with physiological damage from cancer treatment, a patient's coping skills and the quality of the sexual relationship are crucial in sexual rehabilitation. Read More

View Article
October 2018
6 Reads

Cause or prevention of breast cancer with estrogens: analysis from tumor biologic data, growth kinetic model and Women's Health Initiative study.

Authors:
R J Santen W Yue

Climacteric 2018 Nov 1:1-10. Epub 2018 Nov 1.

a Division of Endocrinology and Metabolism , University of Virginia Health Science System , Charlottesville , VA , USA.

The existing medical literature suggests that estrogens may cause breast cancer but, paradoxically, can also prevent this neoplasm under specific circumstances. Appropriate interpretation of this complex data requires an understanding of emerging concepts of tumor biology. A substantial body of data, including animal models and epidemiologic studies, suggests that estrogens contribute to the development of breast cancer. Read More

View Article
November 2018
2 Reads

Effects of different menopausal hormone replacement regimens on body composition in Chinese women.

Climacteric 2018 Oct 31:1-6. Epub 2018 Oct 31.

a Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College , Chinese Academy of Medical Sciences , Beijing , China.

Purpose: The aim of this study was to determine the effects of different menopausal hormone therapy regimens on body composition in healthy postmenopausal Chinese women.

Materials And Methods: One hundred and twenty-three healthy postmenopausal Chinese women were randomly assigned to either group A (0.625 mg conjugated equine estrogens [CEE] plus 100 mg micronized progesterone [MP]), group B (0. Read More

View Article
October 2018
2 Reads

Endocrinopathies and cardiopathies in patients with Turner syndrome.

Climacteric 2018 Nov 1:1-6. Epub 2018 Nov 1.

a Center of Genetic and Prenatal Diagnosis, Department of Gynecology , The First Affiliated Hospital of Zhengzhou University , Henan Province , China.

Ovarian dysgenesis, short stature, and infertility are common features of Turner syndrome (TS). Endocrinopathies and cardiopathies are less common, but may induce significant complications, and are the leading cause of mortality in TS patients. Endocrine abnormality including osteoporosis occurs in up to 60% of patients, hypothyroidism at an incidence of 3. Read More

View Article
November 2018
2 Reads

Case report of the first successful cryopreserved ovarian tissue retransplantation in China.

Climacteric 2018 Oct 31:1-4. Epub 2018 Oct 31.

a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.

Ovarian tissue cryopreservation and retransplantation has been offered as a fertility preservation approach for over a decade. At least 130 live births have been reported after frozen-thawed ovarian tissue transplantation worldwide. The first International Fertility Protection Center in China was established in 2015. Read More

View Article
October 2018
1 Read

Psychometric evaluation of electronic diaries assessing side-effects of hormone therapy.

Climacteric 2018 Oct 29:1-7. Epub 2018 Oct 29.

a Adelphi Mill , Adelphi Values , Bollington , Cheshire , UK.

Objectives: Postmenopausal women (PMW) can experience side-effects (breast pain/tenderness and vaginal spotting/bleeding) associated with estrogen plus progestin therapies (EPTs). To assess these outcomes, the Breast Pain and Tenderness Daily Diary (BPT-DD) and the Vaginal Bleeding and Spotting Daily Diary (VBS-DD) were developed for electronic completion. This study evaluated the psychometric properties of the diaries. Read More

View Article
October 2018
5 Reads

Authors' reply.

Climacteric 2018 Oct 9:1-2. Epub 2018 Oct 9.

a Physical Therapy Department , Federal University of São Carlos , São Carlos , São Paulo , Brazil.

View Article
October 2018
3 Reads

Royal jelly does not prevent bone loss but improves bone strength in ovariectomized rats.

Climacteric 2018 Oct 9:1-6. Epub 2018 Oct 9.

a Department of Obstetrics and Gynecology, School of Medicine , Aichi Medical University , Nagakute , Japan.

Objective: Royal jelly (RJ) has been used for medical and nutritional purposes, and previous studies have indicated that it may have estrogenic activity. The present study investigated the effects of RJ on bone metabolism in ovariectomized (OVX) rats.

Methods: Rats (12 weeks old) were randomly divided into four groups, namely Baseline, Sham, OVX, and OVX + RJ groups. Read More

View Article
October 2018
3 Reads

Menopausal hormone therapy and breast cancer: what is the evidence from randomized trials?

Climacteric 2018 Oct 9:1-8. Epub 2018 Oct 9.

b Department of Obstetrics, Gynecology, and Reproductive Sciences , Yale University School of Medicine , New Haven , CT , USA.

The relationship between menopausal hormone therapy (HT) and breast cancer is complex and further complicated by misinformation, perception, and overgeneralization of data. These issues are addressed in this mini-review through the lens of the Women's Health Initiative (WHI) that has colored the view of HT and breast cancer. In the WHI, unopposed conjugated equine estrogen (CEE) reduced breast cancer risk and mortality. Read More

View Article
October 2018
2 Reads

Thyroid disease in the perimenopause and postmenopause period.

Climacteric 2018 Oct 8:1-7. Epub 2018 Oct 8.

c Department of Internal Medicine, Division of Metabolic Diseases and Endocrinology , Marmara University Hospital , Istanbul , Turkey.

The interpretation of thyroid function tests should be cautiously made during the perimenopause and postmenopause period bearing in mind that physiologic changes do exist in this group of women in terms of secretion and metabolism of thyrotropin and thyroid hormones. Moreover the incidence of thyroid disorders increases in postmenopausal and elderly women. There is no consensus for screening postmenopausal women even though there is well-known evidence about the effect of thyroid status on cognitive function, cardiovascular risk, bone turnover, and longevity. Read More

View Article
October 2018
9 Reads

The use of estradiol metered-dose transdermal spray in clinical practice.

Climacteric 2018 Oct 8:1-5. Epub 2018 Oct 8.

a Department of Gynecology and Obstetrics, 2nd Faculty of Medicine and Faculty Hospital Motol , Charles University Prague , Czech Republic.

Objective: The aim of this study was to evaluate the use of novel estradiol metered-dose transdermal spray (EMDTS) in the treatment of acute climacteric syndrome.

Methods: A multicenter open-label trial was conducted with a 24-week intervention. EMDTS 1. Read More

View Article
October 2018
3 Reads

Evaluation of a crosswalk between the European Quality of Life Five Dimension Five Level and the Menopause-Specific Quality of Life questionnaire.

Climacteric 2018 Oct 8:1-8. Epub 2018 Oct 8.

d Pfizer Ltd , Tadworth , Surrey , UK.

Objectives: Postmenopausal (PM) women taking therapies using estrogens plus progestogens (EPTs) can experience side effects (breast pain, vaginal spotting/bleeding). Sensitivity of the European Quality of Life Five Dimension Five Level (EQ-5D-5L) in measuring quality of life of PM women experiencing side effects of EPTs is unknown. A crosswalk between the Menopause-Specific Quality of Life (MENQOL) questionnaire and the EQ-5D-5L was assessed. Read More

View Article
October 2018
2 Reads

Concerns about the review of vaginal progesterone and the vaginal first-pass effect.

Climacteric 2018 Oct 8. Epub 2018 Oct 8.

a Department of Ob/Gyn and Centre for Perinatal and Reproductive Medicine , Santa Maria della Misericordia University Hospital , Perugia , Italy.

View Article
October 2018
2 Reads

Gynecological-endocrinological aspects in women carriers of BRCA1/2 gene mutations.

Climacteric 2018 Oct 8:1-7. Epub 2018 Oct 8.

d Endocrinology Department, Faculty of Medicine , Pontificia Universidad Católica de Chile , Santiago , Chile.

Women carriers of mutations in the genes BRCA1 and BRCA2 coding for tumor suppressor proteins are at high risk of developing breast and ovarian cancers. Hereditary breast and ovarian cancers due to BRCA pathogenic mutations occur at earlier ages: mean age 43 years at diagnosis of breast cancer for BRCA1 mutations; onset of ovarian cancer up to 10-21% by age 50 years. Preventive strategies are then defined in the reproductive years. Read More

View Article
October 2018
3 Reads

Author's reply.

Climacteric 2018 Oct 8. Epub 2018 Oct 8.

a Department of Endocrinology , Columbia University Medical Center , New York , NY , USA.

View Article
October 2018
1 Read

Does anti-Müllerian hormone predict change in menopausal symptoms following risk-reducing salpingo-oophorectomy? A prospective observational study.

Climacteric 2018 Oct 8:1-7. Epub 2018 Oct 8.

e Department of Laboratory Medicine , The Netherlands Cancer Institute , Amsterdam , the Netherlands.

Objectives: The aim of this study was to investigate whether serum anti-Müllerian hormone (AMH) predicts symptom burden after risk-reducing salpingo-oophorectomy (RRSO) in order to individualize counseling.

Methods: Patient-reported menopausal symptoms, sexual functioning, and psychological distress (depression and anxiety) were assessed 1 day before (T0) and 6 weeks (T1) and 7 months (T2) after RRSO. AMH was assessed before RRSO. Read More

View Article
October 2018
5 Reads

Multichannel electromyography for the assessment of pelvic floor muscle function.

Climacteric 2018 Oct 2:1-2. Epub 2018 Oct 2.

a Division of Gynecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia.

View Article
October 2018
9 Reads
2.260 Impact Factor

The Menopause Visual Analogue Scale: a new tool for measuring the severity and response to treatment of symptoms throughout the menopausal transition.

Climacteric 2018 Oct;21(5):502-508

b Women's Health Concerns Clinic , St. Joseph's Healthcare Hamilton , Hamilton , ON , Canada.

Objectives: This study aimed to assess the reliability and validity of the Menopause Visual Analogue Scale (MVAS) in measuring symptoms throughout the menopausal transition.

Methods: Two independent samples of women undergoing the menopausal transition completed both the MVAS and the Greene Climacteric Scale (GCS) at a women's mental health clinic between 2008 and 2016. Data for the first sample were obtained using a retrospective chart review of patients seen between 2008 and 2012 (N = 75) and data for the second sample came from a prospective study conducted between 2013 and 2016 (N = 86). Read More

View Article
October 2018
2 Reads

Effects of red clover on perimenopausal and postmenopausal women's blood lipid profile: A meta-analysis.

Climacteric 2018 Oct;21(5):446-453

b Centro de Matemática e Aplicações (CMA-UBI) , Universidade da Beira Interior , Covilhã , Portugal.

The study aimed to perform a systematic review with meta-analysis of randomized controlled trials (RCTs) to access the effects of red clover isoflavones on the blood lipid profile of both perimenopausal and postmenopausal women. PubMed, Web of Science, Scopus, SciELO, and Cochrane Library were searched for the terms 'red clover', 'Trifolium pratense', and 'randomized controlled trial' during November 2017. Summary measures were reported as weighted mean differences (WMD) with 95% confidence interval (CI). Read More

View Article
October 2018

Correlation of plasma microRNA-21 expression and bone turnover markers in postmenopausal women.

Climacteric 2018 Sep 20:1-5. Epub 2018 Sep 20.

a Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Objectives: This study assessed the correlation of plasma microRNA-21 expression and bone turnover markers (BTMs: CTx, P1NP) in healthy Thai postmenopausal women. We secondarily compared microRNA-21 expression between participants with normal and low bone mineral density (BMD: osteopenia and osteoporosis).

Methods: Postmenopausal women who had never been diagnosed with fracture or never used anti-osteoporosis drugs were included in this study. Read More

View Article
September 2018
1 Read

Risk factors of long-term mortality in middle-aged women: a 27-year follow-up cohort.

Climacteric 2018 Sep 5:1-5. Epub 2018 Sep 5.

d Clínica Quilín, Facultad de Medicina , Universidad de Chile , Santiago de Chile , Chile.

Objective: This study aimed to evaluate the impact of different risk factors on long-term mortality in middle-aged women.

Methods: Women who received preventive health care control between 1990 and 1993 were recruited. Anamnesis and physical examination were recorded. Read More

View Article
September 2018
2 Reads

Microsatellite variation of ESR1, ESR2, and AR in Serbian women with primary ovarian insufficiency.

Climacteric 2018 Oct 29;21(5):472-477. Epub 2018 Aug 29.

a Gynaecology Research Unit , University Hospitals of Leicester , Leicester , UK.

Objective: This study aimed to investigate the potential role of microsatellite polymorphisms of the estrogen receptor alpha gene (ESR1) TA repeat, estrogen receptor beta gene (ESR2) CA repeat, and androgen receptor gene (AR) CAG and GGN repeats among Serbian women with primary ovarian insufficiency (POI). These microsatellites have been reported to be associated with POI in different racial/ethnic populations.

Methods: A cohort of 196 POI cases matched with 544 fertile controls was recruited by the Institute for Endocrinology, Diabetes and Metabolic Disorders of Serbia between 2007 and 2010. Read More

View Article
October 2018
12 Reads

Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis.

Climacteric 2018 Oct 29;21(5):437-445. Epub 2018 Aug 29.

b Department of Nursing and Midwifery, Razi School of Nursing and Midwifery , Kerman University of Medical Sciences , Kerman , Iran.

Objective: This systematic review and meta-analysis aimed to critically evaluate the effectiveness of phytoestrogens on sexual disorders and severity of dyspareunia.

Materials And Methods: Relevant studies were identified through a systematic search of major databases such as PubMed, Cochrane Library, ISI Web of Science, and Scopus up to 29 September 2017, without any time limit. Two independent reviewers screened all abstracts and full-text articles. Read More

View Article
October 2018
8 Reads

Effects of oral contraceptives on ovulation induction.

Climacteric 2018 Aug 29. Epub 2018 Aug 29.

a Lisbon , Portugal.

View Article
August 2018
1 Read

Bothersome menopausal symptoms amongst postmenopausal Iranian women.

Climacteric 2018 Aug 26:1-8. Epub 2018 Aug 26.

a Women's Health Research Program , School of Public Health and Preventive Medicine, Monash University , Melbourne , Australia.

Objectives: This study was undertaken to determine the impact of menopause on middle-eastern women.

Methods: This was a cross-sectional study of 1520 women, aged 40-64 years, living in Sari, Northern Iran, recruited by multistage cluster sampling between October 2016 and April 2017. All women completed the Menopause Quality of Life Questionnaire (MENQOL) and Beck Depression Inventory-II (BDI-II). Read More

View Article
August 2018
1 Read

'Long-term effects of vaginal erbium laser in the treatment of genitourinary syndrome of menopause': pelvic organ prolapse classification issues.

Climacteric 2018 Oct 20;21(5):515. Epub 2018 Aug 20.

a Department of Obstetrics and Gynecology , Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan.

View Article
October 2018
2 Reads

Author's reply.

Authors:
M Gambacciani

Climacteric 2018 Oct 20;21(5):515-516. Epub 2018 Aug 20.

a Department of Obstetrics and Gynecology , University Hospital of Pisa , Pisa , Italy.

View Article
October 2018
7 Reads

Association between nonalcoholic fatty liver disease and bone mineral density in postmenopausal women.

Climacteric 2018 Oct 20;21(5):498-501. Epub 2018 Aug 20.

d Department of Molecular Cell Biology , Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Suwon , Republic of Korea.

Objective: Growing evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with reduced bone mineral density (BMD). This study examined the association between NAFLD and BMD in postmenopausal Korean women.

Methods: This retrospective cross-sectional study analyzed 3739 postmenopausal women aged 50-59 years who visited a health promotion center for a routine checkup from 2009 to 2014. Read More

View Article
October 2018
3 Reads

Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women.

Climacteric 2018 Oct 14;21(5):509-514. Epub 2018 Aug 14.

c Department of Family Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.

Objective: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women.

Methods: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46. Read More

View Article
October 2018
9 Reads

The effect of vitamin D2 supplementation on muscle strength in early postmenopausal women: a randomized, double-blind, placebo-controlled trial.

Climacteric 2018 Oct 10;21(5):491-497. Epub 2018 Aug 10.

a Reproductive Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been shown to be associated with low muscle mass and loss of muscle strength, resulting in increased disability and frailty in older men and women. Vitamin D deficiency is common in postmenopausal women. The primary objective of the present study was to evaluate the effects of vitamin D supplementation on muscle strength in early postmenopausal women. Read More

View Article
October 2018
7 Reads

Care of the adult woman with Turner syndrome.

Climacteric 2018 Oct 10;21(5):428-436. Epub 2018 Aug 10.

a Department of Endocrinology , Monash Health , Clayton , Victoria , Australia.

Turner syndrome (TS) is the most common chromosomal abnormality in females, affecting up to 1/2000 live female births. TS is associated with partial or complete loss of the second X-chromosome in phenotypic females and is associated with increased morbidity and mortality. There are many challenges in providing optimal care for the adult TS women. Read More

View Article
October 2018
2 Reads

Lack of research reproducibility, the rise of open science and the need for continuing education in research methods.

Authors:
R Haring R J Bell

Climacteric 2018 Oct 22;21(5):413-414. Epub 2018 Jul 22.

a Women's Health Research Program, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

In this opinion piece, we discuss the issue of lack of reproducibility in medical research and the different approaches that are being taken to address this problem. One general approach involves much greater transparency including the pre-publication of a study protocol, analysis plan and analysis code as well as the ultimate sharing of data, doing away with the concept of the 'single wrap-up publication'. The other change required is to support the training and mentorship of young researchers and ensure that they are not working in isolation. Read More

View Article
October 2018
3 Reads

Identification of the first homozygous POLG mutation causing non-syndromic ovarian dysfunction.

Climacteric 2018 Oct 11;21(5):467-471. Epub 2018 Jul 11.

a Department of Obstetrics and Gynecology , Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University , Hefei , China.

Objective: To investigate the genetic cause of non-syndromic ovarian dysfunction in a patient from a consanguineous family.

Methods: This study examined a patient with irregular menstrual cycles and abnormal oocytes. The patient had undergone irregular hormone replacement therapy over 3 years to adjust the menstrual cycle and improve ovarian function. Read More

View Article
October 2018
43 Reads

Progesterone.

Authors:
James H Pickar

Climacteric 2018 Aug;21(4):305

View Article
August 2018
2 Reads

Menopause - a new beginning.

Authors:
Susan R Davis

Climacteric 2018 Aug;21(4):306-307

a President, International Menopause Society.

View Article
August 2018
5 Reads

Sexual well-being after menopause: An International Menopause Society White Paper.

Climacteric 2018 Oct 10;21(5):415-427. Epub 2018 Jul 10.

j Menopause Unit , Mount Sinai Hospital , Toronto , Canada.

Sexual well-being frequently declines following the menopause transition and can be associated with significant personal and relationship distress. This distress is the hallmark of female sexual dysfunction (FSD). FSD is highly prevalent in postmenopausal women. Read More

View Article
October 2018
2 Reads

Progesterone for the prevention and treatment of osteoporosis in women.

Authors:
J C Prior

Climacteric 2018 Aug 2;21(4):366-374. Epub 2018 Jul 2.

a Centre for Menstrual Cycle and Ovulation Research, Department of Medicine, Division of Endocrinology , University of British Columbia , Vancouver , BC , Canada.

Estradiol (E2) is women's dominant 'bone hormone' since it is essential for development of adolescent peak bone mineral density (BMD) and physiological levels prevent the rapid (3-week) bone resorption that causes most adult BMD loss. However, deceasing E2 levels trigger bone resorption/loss. Progesterone (P4) is E2's physiological partner, collaborating with E2 in every cell/tissue; its bone 'job' is to increase P4-receptor-mediated, slow (3-4 months) osteoblastic new bone formation. Read More

View Article
August 2018
4 Reads

Progesterone for treatment of symptomatic menopausal women.

Authors:
J C Prior

Climacteric 2018 Aug 2;21(4):358-365. Epub 2018 Jul 2.

a Centre for Menstrual Cycle and Ovulation Research, Endocrinology and Metabolism , University of British Columbia , Vancouver , BC , Canada.

This review's purpose is to highlight evidence that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely safe in menopausal women (who are more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCT) supplemented with basic science, population and observational data as needed. The barrier to use of progesterone is lack of awareness that safety concerns with estrogen-including 'menopausal hormone therapy' (MHT) are not applicable to progesterone. Read More

View Article
August 2018
2 Reads

Health-related quality of life and its associated factors in Chinese middle-aged women.

Climacteric 2018 Oct 1;21(5):483-490. Epub 2018 Jun 1.

a Department of Gynecology, Women's Hospital, School of Medicine , Zhejiang University , Hangzhou , People's Republic of China.

Objective: The aim of this study was to compare health-related quality of life (HRQOL) by menopausal stage and investigate its associated factors in middle-aged Chinese women.

Method: This was a cross-sectional, community-based study involving 868 participants aged 40-60 years in Gongshu District, Hangzhou, Zhejiang, PR China. HRQOL was assessed by the Short-Form Health Survey (SF-36). Read More

View Article
October 2018
2 Reads

Progesterone, progestins and the breast in menopause treatment.

Climacteric 2018 Aug 1;21(4):326-332. Epub 2018 Jun 1.

a Unité de Gynécologie Endocrinienne, Université Paris Descartes Hôpitaux, Universitaires Port Royal-Cochin , Paris , France.

Breast cancer is the main risk associated with menopause hormone therapy (MHT). It is a hormone-dependent cancer. In postmenopausal women, about 80% of cases are estradiol receptor-positive. Read More

View Article
August 2018
6 Reads

Progesterone and human cognition.

Authors:
V W Henderson

Climacteric 2018 Aug 1;21(4):333-340. Epub 2018 Jun 1.

a Departments of Health Research & Policy (Epidemiology) and of Neurology & Neurological Sciences , Stanford University , Stanford , CA , USA.

Progesterone is a neurosteroid and a neuroactive steroid, produced primarily by the corpus luteum and the placenta. In some animal models, progesterone affects cognitive performance, and its potential role in human cognition is especially germane to women. This role can be investigated through associations between peripheral concentrations of progesterone in blood or saliva and neuropsychological test results, through differences in cognitive profiles between women using menopausal hormone therapy with and without a progestogen, and through clinical trials. Read More

View Article
August 2018
2 Reads

The history of natural progesterone, the never-ending story.

Authors:
P Piette

Climacteric 2018 Aug 28;21(4):308-314. Epub 2018 May 28.

a Consultant at Besins Healthcare Global , Department of R & D, Scientific & Medical Affairs , Brussels , Belgium.

The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium. Read More

View Article
August 2018
5 Reads