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    1 OF 34

    Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women.
    Climacteric 2017 Nov 9:1-7. Epub 2017 Nov 9.
    a Department of Obstetrics and Gynecology , Severance Hospital, Yonsei University College of Medicine , Seoul , Republic of Korea.
    Objective: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. Read More

    Menopause, lung function and obstructive lung disease outcomes: a systematic review.
    Climacteric 2017 Nov 6:1-10. Epub 2017 Nov 6.
    a Allergy and Lung Health Unit, Centre for Epidemiology & Biostatistics , Melbourne School of Population & Global Health, The University of Melbourne , Melbourne , VIC , Australia.
    Background: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies.

    Objective: To systematically summarize the literature regarding the impact of menopause status on respiratory health outcomes.

    Methods: PubMed was searched systematically to identify population-based studies investigating the associations between menopause status and respiratory outcomes including asthma, chronic obstructive pulmonary disease (COPD), respiratory symptoms and lung function. Read More

    Prediction of age at menopause in women with polycystic ovary syndrome.
    Climacteric 2017 Nov 6:1-6. Epub 2017 Nov 6.
    d Endocrine Research Center, Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , I.R. Iran.
    Objective: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later.

    Methods: In total, 1162 women aged 20-50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria. Read More

    Screening for general anxiety disorders in postmenopausal women with symptomatic pelvic organ prolapse.
    Climacteric 2017 Nov 2:1-5. Epub 2017 Nov 2.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , PR China.
    Objective: This study aimed to investigate the prevalence of general anxiety disorder (GAD) among postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify its associated factors.

    Methods: A cross-sectional study was conducted among postmenopausal women with symptomatic POP. Sociodemographic data and medical histories were obtained. Read More

    Metabolic syndrome in menopause and associated factors: a meta-analysis.
    Climacteric 2017 Dec 24;20(6):583-591. Epub 2017 Oct 24.
    a State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology , The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing Medical University , Nanjing , China.
    Objective: Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease and diabetes. Menopause is associated with an increased risk for MetS. The purpose of this meta-analysis is to better understand the relationship between MetS and menopause. Read More

    No increased death toll for long-term menopausal hormone therapy.
    Climacteric 2017 Dec 23;20(6):531-532. Epub 2017 Oct 23.
    a Sackler School of Medicine , Tel-Aviv University , Tel-Aviv , Israel.
    It took many years since the initial publication of data from the Women's Health Initiative (WHI) study until further analyses and additional accumulated clinical information allowed realization of the full scope of its results. At first, the focus was on morbidity, mainly the slightly higher incidence of cardiovascular events and breast cancer cases among postmenopausal hormone users. Then, the age factor became evident, and the good safety profile of hormone therapy in healthy women initiating treatment near menopause and using it for up to 10 years eased the previous concerns. Read More

    Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?
    Climacteric 2017 Dec 17;20(6):505-509. Epub 2017 Oct 17.
    a Department of Investigative Medicine , Imperial College London , London , UK.
    Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Read More

    Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis.
    Climacteric 2017 Dec 16;20(6):522-527. Epub 2017 Oct 16.
    c Department of Nutrition , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
    Aim: There is conflicting evidence regarding the effects of omega-3 fatty acids on bone turnover markers in postmenopausal women. Thus, we systematically reviewed the efficacy of omega-3 fatty acids by conducting a meta-analysis of available randomized controlled trials.

    Methods: PubMed, Embase, Cochrane Library and Scopus were searched in December 2016. Read More

    FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women.
    Climacteric 2017 Dec 5;20(6):577-582. Epub 2017 Oct 5.
    d Department of Neurology, Faculty of Medicine Universitas Indonesia , Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
    Objective: To determine the role of anthropometric measurement, menopausal symptoms and biochemical marker changes as screening methods for mild cognitive impairment (MCI) in postmenopausal women Methods: A cross-sectional study included 282 postmenopausal women in Jakarta, further classified into two groups, with and without MCI. Some related variables such as age, body mass index (BMI), duration of menopause, vasomotor symptoms, hormone levels such as follicle stimulating hormone (FSH), luteinizing hormone, leptin, estradiol, and cognitive status, were assessed and analyzed.

    Results: The FSH levels significantly correlated with MCI incidence (p = 0. Read More

    The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women.
    Climacteric 2017 Dec 22;20(6):552-557. Epub 2017 Sep 22.
    a Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology , Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
    Objective: The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women.

    Methods: A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level >5. Read More

    Foot problems in older women.
    Climacteric 2017 Dec 21;20(6):518-521. Epub 2017 Sep 21.
    a Department of Obstetrics and Gynecology, Faculty of Health Sciences , University of Witwatersrand , Parktown, Johannesburg , South Africa.
    Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated with other co-morbid diseases of the foot. Read More

    The influence of unilateral oophorectomy on the age of menopause.
    Climacteric 2017 Dec 21;20(6):540-544. Epub 2017 Sep 21.
    a Department of Gynecology , Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark.
    Objective: To determine the age of menopause after premenopausal unilateral oophorectomy (UO) and to establish whether UO at a young age leads to menopause at a younger age than if UO occurs at an older age.

    Methods: A cohort of 28 731 women, of whom 17 781 (62%) were menopausal, was investigated. Information on menopause was obtained from self-reported questionnaires. Read More

    Influence of menopausal symptoms on perceived work ability among women in a Nigerian University.
    Climacteric 2017 Dec 21;20(6):558-563. Epub 2017 Sep 21.
    b Department of Family Medicine , Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC) , Ile-Ife , Nigeria.
    Objectives: This study investigated the menopausal symptoms experienced by women of menopausal age in Ekiti State, Nigeria and the influence on their perceived work ability.

    Method: A descriptive cross-sectional research design was employed and the study was conducted among 200 working-class women aged 45 years and above who had experienced at least 12 continuous months of amenorrhea in Ekiti State University, Ado Ekiti. A semi-structured questionnaire adapted from the Greene Climacteric Scale and the work ability index was used to assess menopausal symptoms and work ability, respectively. Read More

    17β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
    Climacteric 2017 Dec 21;20(6):571-576. Epub 2017 Sep 21.
    c Department of Pathology and Oncology , University of Occupational and Environmental Health, School of Medicine , Kitakyushu , Japan.
    Objective: The aim of this report was to evaluate the impact of hormone replacement therapy (HRT) on lymphocytic infiltration of the endometrium in postmenopausal women.

    Method: This study included 58 Japanese patients who had undergone hysterectomy at the University Hospital of Occupational and Environmental Health, Japan. Before surgery, nine patients had received 17β-estradiol (E2), 0. Read More

    Nordic walking increases circulating VEGF more than traditional walking training in postmenopause.
    Climacteric 2017 Dec 17;20(6):533-539. Epub 2017 Sep 17.
    a Department of Medicine and Aging Science , University "G. d'Annunzio", Chieti-Pescara , Chieti , Pescara , Italy.
    Objectives: Nordic walking (NW) is widely practiced by postmenopausal women. Its effects are peculiar owing to the involvement of more muscle groups than in traditional walking training (WT). Since mechanical load promotes secretion of vascular endothelial growth factor (VEGF) from both skeletal muscle and muscle endothelium, the aim of the study was to compare the effect of NW and WT on VEGF levels. Read More

    Native tissue repair versus mesh repair in pelvic organ prolapse surgery.
    Climacteric 2017 Dec 5;20(6):510-517. Epub 2017 Sep 5.
    d 2nd Department of Obstetrics and Gynecology , Hippokratio University Hospital , Thessaloniki , Greece.
    In pelvic organ prolapse, the anatomical defects develop at the anterior (anterior vaginal wall), the posterior (posterior vaginal wall) and the apical (the uterus/cervix or the apex of the vagina, vaginal vault or cuff scar after hysterectomy) compartments. These defects occur in more than one compartment. Treatment of pelvic organ prolapse is commonly surgical, aiming to restore the anatomy of structures supporting the pelvic organs. Read More

    Effects of soy isoflavones on the concentration of hyaluronic acid in the vagina of type 1 diabetic rats.
    Climacteric 2017 Dec 2;20(6):564-570. Epub 2017 Sep 2.
    a Department of Morphology and Genetics , Paulista School of Medicine/Federal University of São Paulo, EPM/UNIFESP , São Paulo , Brazil.
    Objective: To assess the effects of isoflavones and 17β-estradiol on the vaginal epithelium extracellular matrix and hyaluronic acid (HA) in the diabetic rat model.

    Methods: Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups of ten animals each: GI, sham ovariectomized control animals; GII, sham ovariectomized control diabetic animals; GIII, control ovariectomized rats receiving propylene glycol vehicle; GIV, control ovariectomized diabetic animals receiving propylene glycol vehicle; GV, diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage); GVI, ovariectomized diabetic rats treated with estrogen (17β-estradiol, 10 mg/kg, subcutaneously). Treatment took place over 30 consecutive days. Read More

    Experience of menopause in women with inflammatory bowel disease: pilot study.
    Climacteric 2017 Dec 17;20(6):545-551. Epub 2017 Aug 17.
    a Department of Obstetrics & Gynecology, Department of Medicine, Faculty of Medicine and Dentistry , University of Alberta , Edmonton , Canada.
    Objective: Inflammatory bowel diseases (IBD) are debilitating chronic intestinal diseases requiring extensive medical intervention. Little is known how IBD symptoms and treatments affect menopause experience and quality of life. The study's goal was to investigate the relationship between IBD and menopause. Read More

    Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
    Climacteric 2017 Oct 14;20(5):402-413. Epub 2017 Aug 14.
    i Professor Emeritus, Reproductive Biology , Case Western Reserve University , Cleveland , OH , USA.
    The US Preventive Services Task Force (USPSTF) Draft Recommendation statement on Menopausal Hormone Therapy: Primary Prevention for Chronic Diseases, released in May 2017, perpetuates a major disconnect between the primary population affected, women within roughly 10 years of menopause, and the data cited. Furthermore, major elements of the evidence relied upon have been misinterpreted or misstated, particularly in regard to coronary heart disease and breast cancer, for which there is no statistically significant evidence of harm. As currently drafted, the recommendations reiterate the USPSTF statements of 2012, 2005 and 2002, and will perpetuate egregious harm to the public health. Read More

    Age-related differences in left ventricular structure and function between healthy men and women.
    Climacteric 2017 Oct 8;20(5):476-483. Epub 2017 Aug 8.
    a Department of Physiology and Health, Cardiff School of Sport , Cardiff Metropolitan University , Cardiff , UK.
    Objectives: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group.

    Methods: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Read More

    Abnormal uterine bleeding in perimenopause.
    Climacteric 2017 Oct 7;20(5):414-420. Epub 2017 Aug 7.
    b Professor of Medical Education and Gynaecology, Lead for Reproductive and Maternal Medicine, School of Medicine , University of Glasgow , Glasgow , UK.
    Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Read More

    Dependency of cardiovascular risk on reproductive stages and on age among middle-aged Chinese women.
    Climacteric 2017 Oct 3;20(5):484-490. Epub 2017 Aug 3.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
    Objective: To assess the 10-year cardiovascular risk in middle-aged Chinese women living in the same community and the impact of reproductive aging and age.

    Methods: This was a cross-sectional study in the Yuetan Community of Beijing. Data on lifestyle habits, prevalence and treatment of chronic diseases with significance for cardiovascular disease (CVD) development were collected by interview. Read More

    Increased detection of co-morbidities with evaluation at a dedicated adult Turner syndrome clinic.
    Climacteric 2017 Oct 28;20(5):442-447. Epub 2017 Jul 28.
    a Menopause Unit, Monash Medical Centre , Monash Health , Clayton , VIC , Australia.
    Objectives: Turner syndrome (TS), resulting from complete/partial X chromosomal monosomy, is associated with multiple co-morbidities and increased mortality. Although multidisciplinary management is recommended, TS women's health care is sub-optimal. This study evaluates a multidisciplinary adult TS service. Read More

    Factors associated with complementary and alternative medicine use among women at midlife.
    Climacteric 2017 Oct 8;20(5):421-426. Epub 2017 Jul 8.
    a School of Kinesiology and Health Science , York University , Toronto , ON , Canada.
    Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. Read More

    Lichen sclerosus in women: a review.
    Climacteric 2017 Aug 29;20(4):339-347. Epub 2017 Jun 29.
    b Lower Genital Tract Disease Unit , Centro Hospitalar de São João , Porto , Portugal.
    Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Read More

    The UK breast screening program - what you need to know.
    Climacteric 2017 Aug 29;20(4):313-320. Epub 2017 Jun 29.
    a Radiology Department , Norfolk and Norwich University Hospital , Norwich , UK.
    Breast cancer is the most commonly diagnosed cancer in women with a lifetime risk of 1 in 8 in the UK. The disease is associated with considerable morbidity and mortality. The UK breast screening program has been in place for almost 30 years and has evolved with improved diagnostic imaging. Read More

    Monurelle Biogel(®) vaginal gel in the treatment of vaginal dryness in postmenopausal women.
    Climacteric 2017 Oct 28;20(5):467-475. Epub 2017 Jun 28.
    h Zambon SpA , Bresso , Milan , Italy.
    Objectives: To evaluate efficacy, tolerability and safety of Monurelle Biogel(®) vaginal gel for treatment of vaginal dryness.

    Methods: Multicenter, national, randomized, controlled vs. no-treatment, open-label study. Read More

    The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
    Climacteric 2017 Aug 16;20(4):321-330. Epub 2017 Jun 16.
    d Department of Gynecology , University of La Sabana Clinic , Bogota , Colombia.
    Objectives: To evaluate the efficacy and safety of estriol for the treatment of vulvovaginal atrophy in postmenopausal women.

    Methods: A systematic literature review was performed. We searched the following electronic databases: Medline, Cochrane, Embase, Lilacs, CINHAL and Google Scholar. Read More

    Analysis of differential genetic expression in endometrial polyps of postmenopausal women.
    Climacteric 2017 Oct 16;20(5):462-466. Epub 2017 Jun 16.
    a Department of Obstetrics and Gynecology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , SP , Brazil.
    Objectives: To evaluate the expression of four genetic markers (PTEN, BCL2, MLH1, and CTNNB1), linked to endometrial carcinogenesis, in endometrial polyps of patients with and without postmenopausal bleeding in order to determine whether symptomatic endometrial polyps have a genetic phenotype similar to that of endometrial cancer.

    Methods: Samples were obtained hysteroscopically from endometrial polyps of postmenopausal patients, and the expression of genetic markers involved in the pathogenesis of endometrial cancer (PTEN, BCL2, MLH1, and CTNNB1) was analyzed. The expression of these markers was then compared between patients with and without symptoms, which was characterized as postmenopausal bleeding. Read More

    Sleep duration and midlife women's health.
    Climacteric 2017 Dec 14;20(6):528-530. Epub 2017 Jun 14.
    a Sackler Faculty of Medicine , Tel-Aviv University , Tel-Aviv , Israel.
    Sleep is mandatory for life and therefore any sleep deprivation or disruption might carry ill-health outcomes. The optimal night's sleep duration seems to be around 7 h, as too little sleep and too much sleep have been found to be associated with a variety of changes in well-being, physical and psychological parameters. This mini-review enlightens the potential health consequences of sleep disturbance relevant to menopause and midlife women's health. Read More

    Association of objectively measured physical activity and physical fitness with menopause symptoms. The Flamenco Project.
    Climacteric 2017 Oct 3;20(5):456-461. Epub 2017 Jun 3.
    c Department of Physical Education and Sports, Faculty of Sport Sciences , University of Granada , Granada , Spain.
    Objective: The primary aim was to analyze the association of moderate-to-vigorous physical activity (MVPA) with menopause symptomatology and its overall impact. A secondary/exploratory aim was to assess the association of different components of physical fitness with menopause symptomatology.

    Methods: This cross-sectional study comprised 191 perimenopausal women from Southern Spain (age range 45-60 years, mean age 52. Read More

    Low bone mineral density is associated with breast cancer in postmenopausal women: a case-control study.
    Climacteric 2017 Oct 1;20(5):491-497. Epub 2017 Jun 1.
    a Department of Gynecology and Obstetrics , Botucatu Medical School, Sao Paulo State University - UNESP , Sao Paulo , Brazil.
    Objective: To evaluate risk factors for low bone mineral density (BMD) in postmenopausal breast cancer survivors compared with postmenopausal women without breast cancer (controls).

    Method: In this study, 112 breast cancer survivors were compared to 224 women (controls). Inclusion criteria were amenorrhea ≥12 months, age 45-75 years, treated for breast cancer, and metastasis-free for at least 5 years. Read More

    The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis.
    Climacteric 2017 Oct 1;20(5):448-455. Epub 2017 Jun 1.
    b Department of Oncology , Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University , Beijing , China.
    Objectives: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer. Read More

    Water- versus land-based treatment for postural control in postmenopausal osteoporotic women: a randomized, controlled trial.
    Climacteric 2017 Oct 25;20(5):427-435. Epub 2017 May 25.
    b Physical Therapy Department , Federal University of São Carlos , São Carlos , SP , Brazil.
    Objective: To compare the effects of water-based and land-based physical therapy on postural control of older women with osteoporosis.

    Methods: Thirty-six postmenopausal women with osteoporosis were allocated into two groups: land-based or water-based. Volunteers received 12 weeks of a supervised land-based or water-based physical therapy treatment. Read More

    Prevention of postmenopausal osteoporosis in Chinese women: a 5-year, double-blind, randomized, parallel placebo-controlled study.
    Climacteric 2017 Aug 19;20(4):391-396. Epub 2017 May 19.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , People's Republic of China.
    Objectives: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT.

    Design: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group. Read More

    Delay in estrogen commencement is associated with lower bone mineral density in Turner syndrome.
    Climacteric 2017 Oct 19;20(5):436-441. Epub 2017 May 19.
    b Department of Endocrinology , Monash Health , Clayton , VIC , Australia.
    Objective: Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures. We investigated the prevalence and risk factors for low bone density and fractures in a TS cohort.

    Methods: We included 76 TS patients (median age 28. Read More

    Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
    Climacteric 2017 Jun 2;20(3):212-221. Epub 2017 Mar 2.
    a Department of Gynecology , The Netherlands Cancer Institute , Amsterdam , The Netherlands.
    Objectives: To describe implications of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on quality of life, endocrine symptoms, sexual function, osteoporosis, cardiovascular health, metabolic syndrome, cognitive impairment and safety of hormone replacement therapy.

    Methods: We searched the following electronic databases: The Cochrane Library, EMBASE, PsycInfo, and MEDLINE. We selected controlled and uncontrolled trials of premenopausal women undergoing RRSO. Read More

    Custom-compounded bioidentical hormone therapy: why so popular despite potential harm? The case against routine use.
    Climacteric 2017 Jun 9;20(3):205-211. Epub 2017 Feb 9.
    a Service de Gynécologie-Obstétrique , CHU Brugmann, Université Libre de Bruxelles , Bruxelles , Belgium.
    Wide rejection of conventional hormone therapy (HT) after the initial publication of the Women's Health Initiative (WHI) led to unjustified use of custom-compounded bioidentical hormones. In the USA, it became an unregulated drug manufacturer industry in disguise, without proper control and making false claims and misleading advertisements. Manufacturing quality is not ensured. Read More

    Fractional CO2 laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women.
    Climacteric 2017 Aug 15;20(4):379-384. Epub 2017 May 15.
    b Obstetrics and Gynaecology Unit, Umberto I Hospital, Department of Surgical Sciences, School of Medicine , University of Turin , Turin , Italy.
    Objective: To evaluate the effects of CO2 laser in the treatment of vulvovaginal atrophy (VVA) in postmenopausal women.

    Methods: VVA was assessed in 87 postmenopausal women (mean age 58.6 ± 6. Read More

    Tissue-specific effects of estrogen on glycerol channel aquaporin 7 expression in an ovariectomized mouse model of menopause.
    Climacteric 2017 Aug 10;20(4):385-390. Epub 2017 May 10.
    a Department of Reproductive Endocrinology , Zhejiang Provincial People's Hospital , Hangzhou , Zhejiang , PR China.
    Objective: Elevated fat mass and redistribution of body fat are commonly observed in postmenopausal women. Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset of obesity. We hypothesized that estrogen supplementation could counteract this fat accumulation and redistribution through tissue-specific modulation of AQP7. Read More

    Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?
    Climacteric 2017 Jun 29;20(3):222-227. Epub 2017 Apr 29.
    a Department of Reproductive Medicine and Gynecology , University Medical Center Utrecht , Utrecht , The Netherlands.
    To date, the world's leading cause of death amongst women is cardiovascular disease. Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile in early life. Apart from dyslipidemia, obesity and onset of type 2 diabetes mellitus, androgens are thought to influence cardiovascular health. Read More

    Vasomotor symptoms in menopause: a biomarker of cardiovascular disease risk and other chronic diseases?
    Climacteric 2017 Aug 28;20(4):306-312. Epub 2017 Apr 28.
    f Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences , University of Pavia , Pavia , Italy.
    Menopausal disorders may include shorter-term symptoms, such as hot flushes and night sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as cardiovascular disease (CVD), osteoporosis, and cognitive impairment. Initially, no clear link between the shorter-term symptoms and longer-term chronic conditions was evident and these disorders seemed to occur independently from each other. However, there is a growing body of evidence demonstrating that VMS may be a biomarker for chronic disease. Read More

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