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    The European Vulvovaginal Epidemiological Survey (EVES): prevalence, symptoms and impact of vulvovaginal atrophy of menopause.
    Climacteric 2018 Mar 19:1-6. Epub 2018 Mar 19.
    f Imperial College London , London , UK.
    Objectives: The primary objective of the European Vulvovaginal Epidemiological Survey (EVES) was to assess, at a country level, the prevalence of postmenopausal women with vulvovaginal atrophy (VVA) confirmed by gynecological clinical assessment among all postmenopausal women attending menopause centers.

    Method: Women aged 45-75 years old with their last menstrual period more than 12 months before and who attended menopause or gynecology centers were included. If they had at least one VVA symptom, women filled a number of questionnaires including the EuroQoL-EQ-5D3L and Day-to-Day Impact of Vaginal Aging (DIVA). Read More

    Endothelial dysfunction and menopause: is exercise an effective countermeasure?
    Climacteric 2018 Mar 15:1-9. Epub 2018 Mar 15.
    b Department of Kinesiology , University of Massachusetts Amherst , Amherst , MA , USA.
    Cardiovascular disease is the leading cause of death in women. There is a dramatic rise in risk factors for cardiovascular disease during the menopausal transition that is independent of aging. Endothelial dysfunction is an early hallmark of developing cardiovascular disease and has been shown to increase across the stages of menopause. Read More

    Influence of hormone therapy or C. foetida extract on breast tenderness in postmenopausal women.
    Climacteric 2018 Mar 15:1-6. Epub 2018 Mar 15.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China.
    Objective: To evaluate the prevalence of breast tenderness in a population treated with menopausal hormone therapy (MHT) or Cimicifuga foetida extract.

    Methods: A prospective, randomized, controlled trial was conducted. Ninety-six postmenopausal women were randomly assigned to three groups: group A, 1 mg estradiol valerate daily plus 4 mg medroxyprogesterone acetate (MPA), days 19-30; group B, 1 mg estradiol valerate daily plus 100 mg micronized progesterone (MP), days 19-30; group C, 100 mg C. Read More

    Menopausal hormone therapy: a better and safer future.
    Climacteric 2018 Mar 11:1-8. Epub 2018 Mar 11.
    a Faculty of Health Sciences , University of Cape Town , Western Cape , South Africa.
    Major advances in menopause hormone therapy (MHT) hold promise in the future of better and safer care for women at and after the menopause. The principal advances are: (1) the critical window or 'window of opportunity' in the 10 years or so after the menopause, during which the benefits of MHT in healthy women exceed any risks; (2) use of transdermal instead of oral administration of estrogen to reduce the risk of venous thromboembolism; (c) investigation of the use of oral micronized progesterone (MP) and vaginal MP to prevent endometrial hyperplasia and carcinoma without any increased risk of breast cancer and venous thromboembolism in postmenopausal women receiving estrogens; vaginal MP prevents endometrial proliferation in the short term but the long-term effects in MHT remain to be established; (4) investigation into the use of intrauterine levonorgestrel-releasing devices (LNG-IUDs), which are an attractive form of MHT in perimenopausal women, providing contraception and reducing uterine bleeding, although the risk of breast cancer with LNG-IUDs requires clarification. Women in the future can look forward to a symptom-free menopause and to safer and more beneficial MHT. Read More

    Migraine, hormones and the menopausal transition.
    Climacteric 2018 Mar 9:1-11. Epub 2018 Mar 9.
    c Department of Gynecology , Université Paris Descartes, HUPC , Paris , France.
    Migraine is a common, disabling and incapacitating headache disorder that may be triggered by many factors, such as hormones especially during the perimenopausal period, where large alterations in estradiol levels can occur. The evidence implies that hormonal fluctuations are one of the important triggers of migraine. During reproductive life and during hormonal contraception, the course of migraine can be impacted. Read More

    Carotid intima-media thickness and osteoporosis in postmenopausal women: a cross-sectional study.
    Climacteric 2018 Mar 9:1-6. Epub 2018 Mar 9.
    c Department of Orthopaedics, Faculty of Medicine , Khon Kaen University , Khon Kaen , Thailand.
    Objectives: To explore the difference in carotid intima-media thickness (CIMT) between postmenopausal women with and without osteoporosis and the risk of elevated CIMT and plaque presentation.

    Method: A cross-sectional study was conducted including 46 postmenopausal women with osteoporosis and 45 non-osteoporotic postmenopausal women. CIMT was measured using B-mode ultrasound. Read More

    Surgical challenges in the treatment of perimenopausal and postmenopausal endometriosis.
    Climacteric 2018 Mar 1:1-6. Epub 2018 Mar 1.
    c Department of Obstetrics and Gynecology , Egemed Hospital , Aydin , Turkey.
    Endometriosis is classically defined as a chronic, recurrent and progressive disease. It is known to be estrogen-dependent, but can still be observed during the peri- and postmenopausal periods. Medical management of endometriosis is palliative symptomatic relief. Read More

    The role of transvaginal ultrasound in screening for ovarian cancer.
    Climacteric 2018 Mar 1:1-6. Epub 2018 Mar 1.
    b Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health , University College London , London , UK.
    Ovarian cancer is a low-prevalence postmenopausal cancer with a high mortality rate and is the fifth most lethal cancer in women. The most common serous subtype with TP53 mutations spreads rapidly throughout the peritoneal cavity (stage III/IV) when 5-year survival is 10%. If diagnosed while confined to the ovary (stage I), the survival rate exceeds 90%. Read More

    Effects of oral contraceptives on ovulation induction in in vitro fertilization patients with premature ovarian insufficiency.
    Climacteric 2018 Feb 28:1-4. Epub 2018 Feb 28.
    a Navy Clinical Medical School , Anhui Medical University , Hefei , China.
    Objective: To report a case series of in vitro fertilization patients with premature ovarian insufficiency, who were treated with oral contraceptives to reduce follicle stimulating hormone levels.

    Method: This was a consecutive case series in a tertiary teaching hospital in China. Twenty-two women with refractory and idiopathic premature ovarian insufficiency were administered a drospirenone/ethinylestradiol oral contraceptive orally. Read More

    Innovative approaches to cervical cancer screening in low- and middle-income countries.
    Climacteric 2018 Feb 28:1-4. Epub 2018 Feb 28.
    a Sexual and Reproductive Health Unit , Papua New Guinea Institute of Medical Research , Goroka , Papua New Guinea.
    The estimated cervical cancer burden is over ten-fold greater in low- and middle-income countries (LMICs) than in high-income countries. This health gap is thought to be primarily due to limited access to effective screening and treatment programs for cervical pre-cancer and cancer in such settings. The World Health Organization advocates a policy of 'screen and treat' approach to cervical screening in LMICs and subsequently visual inspection of the cervix with acetic acid (VIA) or Lugo's iodine (VILI), followed by ablative cervical cryotherapy if indicated, and this policy has been implemented in many high-burden settings. Read More

    Should women be screened for osteoporosis at midlife?
    Climacteric 2018 Feb 15:1-4. Epub 2018 Feb 15.
    a Department of Gynecology, Faculty of Health Sciences , Stellenbosch University , Stellenbosch , South Africa.
    Osteoporosis and associated fractures are common in women after midlife and will increase as the population ages. Osteoporosis-related fractures cause a significant increase in morbidity and mortality. Osteoporosis decreases the quality of life and productivity of many older women, with an increasing burden on health-care resources. Read More

    Role of breast density measurement in screening for breast cancer.
    Climacteric 2018 Feb 15:1-7. Epub 2018 Feb 15.
    a Centre for Genetic Origins of Health and Disease , Curtin University and The University of Western Australia , Perth , WA , Australia.
    Mammographic breast density is an established risk factor for breast cancer and significantly reduces the sensitivity of mammography, yet its use within breast cancer screening programs in Australia is limited. We provide a contemporary snapshot of the role of breast density measurement in screening for breast cancer and review the recent evidence for an increasing role of breast density measurement as: a predictor of breast cancer risk, a predictor of 'masking', and a biomarker to monitor effectiveness of intervention strategies for primary prevention or improved breast cancer outcomes. Read More

    Long-term effects of vaginal erbium laser in the treatment of genitourinary syndrome of menopause.
    Climacteric 2018 Apr 13;21(2):148-152. Epub 2018 Feb 13.
    c Department of Obstetrics and Gynecology , Catholic University of the Sacred Heart , Rome , Italy.
    Objectives: To evaluate the long-term efficacy of a second generation of vaginal laser treatment, the vaginal erbium laser, as a non-ablative photothermal therapy for the management of genitourinary syndrome of menopause.

    Methods: The study was performed using an erbium laser crystal yttrium-aluminum-garnet (XS Fotona Smooth™, Fotona, Ljubljana, Slovenia) with a wavelength of 2940 nm. Postmenopausal women (n = 205) were treated with three laser applications at 30-day intervals. Read More

    Romosozumab treatment in postmenopausal women with osteoporosis: a meta-analysis of randomized controlled trials.
    Climacteric 2018 Apr 9;21(2):189-195. Epub 2018 Feb 9.
    b Department of Pharmacy , Sun-Yat-Sen Memorial Hospital, Sun Yat-sen University , Guangzhou , PR China.
    Aim: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of romosozumab in the treatment of postmenopausal osteoporosis.

    Method: A comprehensive literature review was performed of PubMed, EMBASE, Cochrane Controlled Trials Registry, and Web of Science for RCTs. Outcome measures were changes in lumbar spine, total hip and femoral neck bone mineral density (BMD), incidence of fractures and adverse events. Read More

    Decision-making about mammographic screening: pursuing informed choice.
    Climacteric 2018 Feb 8:1-5. Epub 2018 Feb 8.
    a Wiser Healthcare, School of Public Health , The University of Sydney , Sydney , Australia.
    For decades, persuasive techniques have been used to communicate to women about breast cancer screening with the aim of maximizing screening uptake. However, more recently this has shifted to an approach which recognizes that it is important for women to be aware of harms, such as overdiagnosis, as well as benefits of breast screening. There is a lack of consensus in the literature around whether benefits clearly outweigh harms for population-based breast cancer screening. Read More

    Genitourinary syndrome of menopause. Prevalence and quality of life in Spanish postmenopausal women. The GENISSE study.
    Climacteric 2018 Apr 7;21(2):167-173. Epub 2018 Feb 7.
    g Departamento Médico , ITF Research Pharma S.L.U. , Madrid , Spain.
    Objective: To determine the prevalence of genitourinary syndrome of menopause (GSM) and urogynecological conditions associated with menopause, and to evaluate the impact of GSM on quality of life in a cohort of Spanish postmenopausal women.

    Methods: Multicenter, cross-sectional, and observational study involving 430 women.

    Results: The prevalence of GSM was 70%. Read More

    Depressive symptoms affect outcomes of pessary use in postmenopausal women with uterine prolapse.
    Climacteric 2018 Apr 3;21(2):184-188. Epub 2018 Feb 3.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , PR China.
    Objective: This study aimed to investigate the impact of depressive symptoms on successful pessary treatment for postmenopausal women with symptomatic pelvic organ prolapse (POP).

    Methods: We performed a prospective study involving postmenopausal women with POP who visited our clinic seeking pessary treatment. Demographic information and medical histories were collected. Read More

    Vasomotor symptoms: natural history, physiology, and links with cardiovascular health.
    Climacteric 2018 Apr 2;21(2):96-100. Epub 2018 Feb 2.
    a Departments of Psychiatry, Psychology, and Epidemiology , University of Pittsburgh , Pittsburgh , PA , USA.
    Vasomotor symptoms (VMS), or hot flushes and night sweats, are the classic symptom of menopause. Recent years have brought key advances in the knowledge about VMS. VMS last longer than previously thought, on average 7-10 years for frequent or moderate to severe VMS. Read More

    Association of body composition with menopausal symptoms in (peri-)menopausal women.
    Climacteric 2018 Apr 2;21(2):179-183. Epub 2018 Feb 2.
    a Department of Gynecology and Obstetrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , People's Republic of China.
    Objective: To explore the correlation of body composition with the severity of menopausal symptoms, as well as each classic menopausal symptom.

    Methods: A total of 758 (peri-)menopausal women were recruited (aged from 40 to 67 years) from the Menopause Clinic in the Shanghai Sixth People's Hospital. Different regions of fat mass, lean mass and fat-free mass were measured by bioelectrical impedance analysis, while menopausal symptoms were evaluated by valid modified Kupperman's index (KMI) in the Chinese version. Read More

    The impact of micronized progesterone on breast cancer risk: a systematic review.
    Climacteric 2018 Apr 31;21(2):111-122. Epub 2018 Jan 31.
    c Clinic for Gynecological Endocrinology and Reproductive Medicine , RWTH University of Aachen , Aachen , Germany.
    Postmenopausal women with an intact uterus using estrogen therapy should receive a progestogen for endometrial protection. The debate on bioidentical hormones including micronized progesterone has increased in recent years. Based on a systematic literature review on the impact of menopausal hormone therapy (MHT) containing micronized progesterone on the mammary gland, an international expert panel's recommendations are as follows: (1) estrogens combined with oral (approved) or vaginal (off-label use) micronized progesterone do not increase breast cancer risk for up to 5 years of treatment duration; (2) there is limited evidence that estrogens combined with oral micronized progesterone applied for more than 5 years are associated with an increased breast cancer risk; and (3) counseling on combined MHT should cover breast cancer risk - regardless of the progestogen chosen. Read More

    Influence of menopausal status on the main contributors of muscle quality.
    Climacteric 2018 Jan 30:1-5. Epub 2018 Jan 30.
    b Department of Physical Activity Sciences , University of Quebec in Montreal , Montreal , QC , Canada.
    Background: Muscle quality is a strong independent predictor of physical function. Body mass and fatness, muscle mass and cardiorespiratory fitness are known to influence muscle quality.

    Objective: To identify the contributors of muscle quality in young and postmenopausal women and whether hormone replacement therapy (HT) could influence this relationship at the age of menopause. Read More

    Treatment of vaginal atrophy with estriol and lactobacilli combination: a clinical review.
    Climacteric 2018 Apr 30;21(2):140-147. Epub 2018 Jan 30.
    d Department of Obstetrics & Gynecology , University Medical Center Regensburg , Regensburg , Germany.
    In recent years, a vast quantity of clinical data has been accumulated on the pathophysiology of symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) in peri- and postmenopausal women and on the treatment options for these conditions. Guidelines from several societies have recently been updated in favor of VVA/GSM vaginal therapy with the lowest possible doses of estrogens. The combination of a vaginal ultra-low dose of 0. Read More

    Female hormonal factors and osteoarthritis of the knee, hip and hand: a narrative review.
    Climacteric 2018 Apr 30;21(2):132-139. Epub 2018 Jan 30.
    a School of Public Health and Preventive Medicine , Monash University , Melbourne , VIC , Australia.
    Osteoarthritis is a leading cause of disability with no cure. The incidence of osteoarthritis is sexually dimorphic: women have a higher rate of osteoarthritis than men after the age of 50. Research has investigated the contribution of sex hormones, reproductive factors and hormone supplementation to osteoarthritis. Read More

    Role of topical oxytocin in improving vaginal atrophy in postmenopausal women: a randomized, controlled trial.
    Climacteric 2018 Apr 19;21(2):174-178. Epub 2018 Jan 19.
    e Department of Pathology , Cairo University , Cairo , Egypt.
    Objective And Design: Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women.

    Patients And Methods: A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination were performed before and after treatment. Read More

    Effects of physical and depressive symptoms on the sexual life of Turkish women in the climacteric period.
    Climacteric 2018 Apr 18;21(2):160-166. Epub 2018 Jan 18.
    a Faculty of Health Science, Obstetrics and Gynaecology Nursing , Manisa Celal Bayar University , Manisa , Turkey.
    Objective: To assess the effects of physical and depressive symptoms on the sexual life of women in the climacteric period.

    Methods: This study was conducted with 572 women at a university hospital. The Beck Depression Inventory (BDI), Menopause Rating Scale (MRS) and Female Sexual Function Index (FSFI) were used to evaluate depressive symptoms, intensity of menopausal symptoms and sexual function. Read More

    Experiences of menopause, self-management strategies for menopausal symptoms and perceptions of health care among immigrant women: a systematic review.
    Climacteric 2018 Apr 18;21(2):101-110. Epub 2018 Jan 18.
    a School of Public Health and Preventive Medicine, Jean Hailes Research Unit , Monash University Faculty of Medicine Nursing and Health Sciences , Melbourne , VIC , Australia.
    Objective: To systematically review the published literature relating to experiences of menopause, self-management strategies for menopausal symptoms and health-care needs among immigrant women.

    Methods: A systematic literature search of English-language publications was performed using Medline, Embase, PsychInfo, Cinahl and Scopus. Twenty-four papers reporting on 19 studies met our inclusion criteria and investigated immigrant women's experiences of menopause and/or their self-management strategies for menopausal symptoms and/or their perceptions of menopause-specific health care. Read More

    The role of screening mammography in the era of modern breast cancer treatment.
    Climacteric 2018 Jan 17:1-5. Epub 2018 Jan 17.
    a Dalla Lana School of Public Health , University of Toronto , Toronto , ON , Canada.
    The evidence is reviewed on the efficacy and effectiveness of mammography screening derived from randomized screening trials and from the surveillance of populations where mammography screening for breast cancer has been introduced. Nearly all the trials were performed in the era before modern adjuvant therapy for breast cancer was introduced, apart from the Canadian National Breast Screening Study and the UK Age trial. The former found no benefit from annual mammography screening for 5 years in women age 40-59 years, the latter, a non-significant benefit from screening women by annual mammography for 7 years from ages 39 to 41 years. Read More

    Selective progesterone receptor modulators: current applications and perspectives.
    Climacteric 2018 Jan 17:1-5. Epub 2018 Jan 17.
    b Endocrinology Unit , University Hospital Paris Est, Saint Antoine APHP, University Pierre and Marie Curie , Paris , France.
    Selective progesterone receptor modulators (SPRMs) are steroid progesterone receptor ligands able to induce agonistic or antagonistic activities. Mifepristone, the class leader, was primarily used for pregnancy termination from the 1980s. Emergency contraception with extended activity was the second major development 30 years later, with mifepristone in some countries and ulipristal acetate world-wide. Read More

    Effects of black cohosh and estrogen on core body and tail-skin temperatures in ovariectomized rats by telemetric monitoring with dual thermistor probes.
    Climacteric 2018 Apr 11;21(2):153-159. Epub 2018 Jan 11.
    e Department of Physiology and Pathophysiology, School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.
    Objectives: To investigate the effects of black cohosh and estrogen on the temperature in ovariectomized rats, the core body temperature (CBT) and tail-skin temperature (TST) were simultaneously monitored and the relationship between these two temperatures was explored.

    Methods: Twenty-four female Sprague-Dawley rats aged 8 weeks were randomly divided into four groups: sham-operated (SHAM), ovariectomized (OVX), OVX treated with estradiol valerate (OVX + E), and OVX treated with isopropanolic black cohosh extract (OVX + ICR). Rats were sham-operated or ovariectomized and were implanted with telemetry transmitters with dual thermistor probes. Read More

    The effect of programmed exercise over anxiety symptoms in midlife and older women: a meta-analysis of randomized controlled trials.
    Climacteric 2018 Apr 8;21(2):123-131. Epub 2018 Jan 8.
    a Facultad de Medicina , Universidad de Zaragoza & Instituto Aragonés de Ciencias de la Salud (IACS) , Zaragoza , Spain.
    We aimed to perform a systematic review and meta-analysis in order to clarify the effect of programmed exercise over mild-to-moderate anxiety symptoms (ASs) in midlife and older women. A structured search of PubMed, Medline, Web of Science, Scopus, Embase, Cochrane Library, Scielo, and the US, UK and Australian Clinical Trials databases (from inception through July 27, 2017) was performed, with no language restriction using the following terms: 'anxiety', 'anxiety symptoms', 'exercise', 'physical activity', 'menopause', and 'randomized controlled trial' (RCTs) in mid-aged and older women. We assessed RCTs that compared the effect of exercise for at least 6 weeks versus no intervention over ASs as outcome (as defined by trial authors). Read More

    Clinicopathological and prognostic significance of platelet count in patients with ovarian cancer.
    Climacteric 2018 Feb 12;21(1):60-68. Epub 2017 Dec 12.
    a Department of Gynecology and Obstetrics , The People's Hospital of Three Gorges University/The First People's Hospital of Yichang , Yichang , China.
    Aim: Increasing evidence indicates that platelet count is a useful biomarker of long-term outcomes in patients with ovarian cancer. However, the prognostic value of platelet count in patients with ovarian cancer remains controversial. We therefore conducted a meta-analysis aimed to investigate the prognostic role of the platelet count in patients with ovarian cancer. Read More

    Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats.
    Climacteric 2018 Feb 12;21(1):75-81. Epub 2017 Dec 12.
    a Universidade Federal de São Paulo. Escola Paulista de Medicina , Departamento de Morfologia e Genética , São Paulo , Brasil.
    Aim: To evaluate the combined effects of streptozotocin-induced diabetes (Di) and ovariectomy in the articular cartilage of rats.

    Methods: Forty adult female Wistar rats were ovariectomized (OVX) or sham-operated. After recovery from surgery, the animals were assigned randomly into four groups: OVX control (OVX-C); OVX treated with 10 µg/kg/day of 17β-estradiol (OVX-E); sham-operated subjected to Di (Sham-Di); and OVX subjected to Di (OVX-Di). Read More

    Predictors of malignancy in endometrial polyps: study of 421 women with postmenopausal bleeding.
    Climacteric 2018 Feb 8;21(1):82-87. Epub 2017 Dec 8.
    a Institute of Cancer and Genomic Sciences , University of Birmingham , Birmingham , UK.
    Objective: There is lack of consensus as whether benign-looking endometrial polyps should be removed in postmenopausal women. To help inform clinical practice, this study was conducted to quantify the prevalence and identify the predictors of hyperplasia and cancer in polyps.

    Methods: The data of 2625 consecutive women attending a postmenopausal bleeding clinic were collected prospectively in a UK teaching hospital between January 2011 and December 2015. Read More

    The futile case of the aging ovary: is it mission impossible? A focused review.
    Climacteric 2018 Feb 8;21(1):22-28. Epub 2017 Dec 8.
    a Department of Reproductive Medicine , Gynaecworld , Mumbai , India.
    Despite immense and impressive progress in the field of reproductive medicine, little has been achieved in terms of replenishing aged ovaries and improving their reproductive outcome. Age causes irreversible damage to human eggs in terms of quantity as well as quality. Nature probably designed women to reproduce best in their twenties and thirties. Read More

    Efficacy and safety evaluation of Cimicifuga foetida extract in menopausal women.
    Climacteric 2018 Feb 4;21(1):69-74. Epub 2017 Dec 4.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China.
    Objective: The aim of this study was to evaluate the efficacy and safety of long-term treatment with Cimicifuga foetida extract in menopausal women.

    Methods: A prospective, randomized, controlled clinical trial was conducted. A total of 96 early postmenopausal women were randomly assigned to three groups: group A received 1 mg estradiol valerate daily plus 4 mg medroxyprogesterone acetate on days 19-30; group B received 1 mg estradiol valerate daily plus 100 mg micronized progesterone on days 19-30; group C received 100 mg C. Read More

    Pregnancy history, coronary artery calcification and bone mineral density in menopausal women.
    Climacteric 2018 Feb 30;21(1):53-59. Epub 2017 Nov 30.
    b Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester , MN , USA.
    Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women.

    Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4-9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Read More

    Depressive symptoms and their risk factors in midlife women in the Middle East: a systematic review.
    Climacteric 2018 Feb 30;21(1):13-21. Epub 2017 Nov 30.
    e Women's Health Research Program, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.
    Introduction: Women may experience different menopausal symptoms across different cultures around the world. The purpose of this study was to determine the prevalence and contributing factors of depression in midlife women in the Middle East.

    Methods: Electronic databases including PubMed, Medline, PsycINFO, CINAHL, Web of Science, SCOPUS, and Google scholar were searched. Read More

    Endometriosis resembling endometrial cancer in a postmenopausal patient.
    Climacteric 2018 Feb 23;21(1):88-91. Epub 2017 Nov 23.
    a 1st Department of Obstetrics and Gynecology , Warsaw Medical University , Warsaw , Poland.
    Endometriosis occurs in 2-4% of postmenopausal women. There have been a few reports of endometriosis in women in whom neither history nor diagnostic imaging indicated the presence of this disease, either at reproductive age or after menopause. A case is described of an 84-year-old patient with extensive deep pelvic endometriosis imitating advanced neoplastic process. Read More

    The use and discontinuation of hormone replacement therapy in women in South China.
    Climacteric 2018 Feb 23;21(1):47-52. Epub 2017 Nov 23.
    a School of Medicine , Women's Hospital, Zhejiang University , Hangzhou , PR China.
    Objective: The use of hormone replacement therapy (HRT) started later in China than in European countries. The purpose of the present study was to investigate HRT patterns and reasons for the initiation and discontinuation of HRT among women in South China.

    Methods: A telephone survey about menopausal status, the use of HRT, reasons for HRT discontinuation and duration of HRT treatment was conducted in 2014. Read More

    Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women.
    Climacteric 2018 Feb 9;21(1):40-46. Epub 2017 Nov 9.
    a Department of Obstetrics and Gynecology , Severance Hospital, Yonsei University College of Medicine , Seoul , Republic of Korea.
    Objective: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. Read More

    Menopause, lung function and obstructive lung disease outcomes: a systematic review.
    Climacteric 2018 Feb 6;21(1):3-12. Epub 2017 Nov 6.
    a Allergy and Lung Health Unit, Centre for Epidemiology & Biostatistics , Melbourne School of Population & Global Health, The University of Melbourne , Melbourne , VIC , Australia.
    Background: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies.

    Objective: To systematically summarize the literature regarding the impact of menopause status on respiratory health outcomes.

    Methods: PubMed was searched systematically to identify population-based studies investigating the associations between menopause status and respiratory outcomes including asthma, chronic obstructive pulmonary disease (COPD), respiratory symptoms and lung function. Read More

    Prediction of age at menopause in women with polycystic ovary syndrome.
    Climacteric 2018 Feb 6;21(1):29-34. Epub 2017 Nov 6.
    d Endocrine Research Center, Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , I.R. Iran.
    Objective: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later.

    Methods: In total, 1162 women aged 20-50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria. Read More

    Screening for general anxiety disorders in postmenopausal women with symptomatic pelvic organ prolapse.
    Climacteric 2018 Feb 2;21(1):35-39. Epub 2017 Nov 2.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , PR China.
    Objective: This study aimed to investigate the prevalence of general anxiety disorder (GAD) among postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify its associated factors.

    Methods: A cross-sectional study was conducted among postmenopausal women with symptomatic POP. Sociodemographic data and medical histories were obtained. Read More

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