1,856 results match your criteria Climacteric[Journal]


Current treatments for female primary stress urinary incontinence.

Climacteric 2019 Feb 18:1-7. Epub 2019 Feb 18.

a Department of Obstetrics and Gynaecology, Helsinki University Hospital , Helsinki University , Helsinki , Finland.

Stress urinary incontinence (SUI) affects millions of women worldwide. Pelvic floor muscle training is the first-line treatment for SUI, and if this fails, midurethral sling surgery has become the gold-standard treatment. More recently, complications from midurethral mesh slings, particularly chronic pain and dyspareunia, have become a major concern. Read More

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http://dx.doi.org/10.1080/13697137.2019.1568404DOI Listing
February 2019
1 Read

On the human condition.

Authors:
Rod Baber

Climacteric 2019 Feb;22(1):1-2

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http://dx.doi.org/10.1080/13697137.2019.1558875DOI Listing
February 2019

Advances in surgical strategies for prolapse.

Climacteric 2019 Feb;22(1):60-64

a Division of Obstetrics and Gynecology, Department of Experimental and Clinical Medicine , University of Pisa , Pisa , Italy.

Pelvic floor dysfunctions are a complex condition in elderly women; pelvic organ prolapse, urinary or fecal incontinence, constipation, pelvic pain, and sexual dysfunction are common problems. The goal of surgical treatment is functional reconstruction with symptom management and repair of anatomic defects. The recent advancements in surgical treatment of pelvic floor dysfunction allow several good options for choosing the best surgery for each patient. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543266DOI Listing
February 2019
2 Reads

Uterine transplantation.

Authors:
V Gomel

Climacteric 2019 Feb 4:1-5. Epub 2019 Feb 4.

a Department of Obstetrics & Gynecology , University of British Columbia , Vancouver , BC , Canada.

Successful human uterine transplantation followed by subsequent pregnancy and live birth in a woman for whom this would otherwise have been impossible is a laudable goal. Research programs have been developed in several countries aimed at achieving this goal. The pioneering Swedish program has reported live births in six women, two of whom had a second pregnancy and birth. Read More

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http://dx.doi.org/10.1080/13697137.2018.1564271DOI Listing
February 2019

Hierarchical measurement structure in the Women's Health Questionnaire: a confirmatory factor analysis.

Climacteric 2019 Feb 4:1-6. Epub 2019 Feb 4.

c Medicine Department , University of Southern California , Los Angeles , CA , USA.

Purpose: This study conducted confirmatory factor analysis (CFA) to examine the measurement structure of the Women's Health Questionnaire (WHQ) and how its components were organized.

Methods: Participants were 448 postmenopausal women, with a mean age of 63.3 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1564270DOI Listing
February 2019

Metabolic syndrome during female midlife: what are the risks?

Climacteric 2019 Feb 4:1-6. Epub 2019 Feb 4.

b Department of Obstetrics and Gynecology , University of Zaragoza Faculty of Medicine and Lozano-Blesa University Hospital , Zaragoza , Spain.

The metabolic syndrome (METS) is an entity diagnosed by three or more of the following factors: abdominal obesity, low high-density lipoprotein cholesterol, and high serum triglycerides, fasting glucose, and/or blood pressure levels. Abdominal obesity is the most prevalent component of the syndrome that favors insulin resistance and a proinflammatory and prothrombotic status, and the risk of developing diabetes, hypertension, and other chronic conditions. During the menopausal transition, women tend to gain weight and this has been related to an increase in the prevalence of the METS. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561666DOI Listing
February 2019
3 Reads

The evolution of the human menopause.

Climacteric 2019 Feb 4:1-6. Epub 2019 Feb 4.

b Department of Obstetrics and Gynaecology , Princess Royal Maternity Hospital , Glasgow , UK.

The females of most species die soon after ceasing to reproduce, their purpose in life being to ensure survival of their kin. Human females may live more than one-third of their lives after they cease to reproduce, a property shared by few species, one of which is Orca whales. Orcas have been extensively studied because families live together in stable units or pods and individual whales have distinctive markings, enabling them to be identified. Read More

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http://dx.doi.org/10.1080/13697137.2018.1547701DOI Listing
February 2019
2 Reads

Esmirtazapine treatment of postmenopausal vasomotor symptoms: two randomized controlled trials.

Climacteric 2019 Feb 4:1-11. Epub 2019 Feb 4.

e MSD , Munich , Germany.

Objectives: Two identical 12-week, randomized, double-blind, placebo-controlled, multi-arm, parallel-group Phase III studies (Study P012, NCT00560833; Study P013, NCT00535288) evaluated the efficacy and safety of esmirtazapine, an investigational medicine, for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women.

Methods: Participants were randomized to placebo or esmirtazapine (2.25, 4. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561664DOI Listing
February 2019
1 Read

Do we have new preventive strategies for optimizing cardiovascular health in women?

Authors:
C A Stuenkel

Climacteric 2019 Feb 4:1-7. Epub 2019 Feb 4.

a Department of Medicine, Division of Endocrinology and Metabolism , University of California, San Diego, School of Medicine , La Jolla , CA , USA.

Over the past decades, progress in efforts to reduce cardiovascular morbidity and mortality has been achieved, although a disturbing trend for stagnation of cardiovascular mortality rates among younger women compared with those in younger men has been identified. While the menopause transition has traditionally offered an unequivocal opportunity to assess cardiovascular risk and counsel women to adopt preventive strategies, the veritable 'window of opportunity', usually applied to the concept of timing the initiation of menopausal hormone therapy, must be opened much wider to encompass younger women including those who have experienced adverse events during pregnancy, treatment for breast cancer, and premature menopause. Collaborative efforts by a number of expert medical groups provide encouragement and justification for an aggressive approach to identify and modify cardiovascular risk earlier in younger women, starting at age 20 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1561665DOI Listing
February 2019
1 Read

Rationale and design for fractional microablative CO laser versus photothermal non-ablative erbium:YAG laser for the management of genitourinary syndrome of menopause: a non-inferiority, single-blind randomized controlled trial.

Climacteric 2019 Jan 24:1-5. Epub 2019 Jan 24.

c First Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens , Athens , Greece.

Genitourinary syndrome of menopause (GSM) is a common condition affecting up to 50% of postmenopausal women and up to 70% of postmenopausal breast cancer survivors. GSM is a chronic condition with a significant impact on sexual health and quality of life. The mainstay of treatment has been with symptomatic relief using topical emollients or lubricants. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1559806DOI Listing
January 2019
3 Reads

Ovarian tissue cryopreservation for patients with premature ovary insufficiency caused by cancer treatment: optimal protocol.

Climacteric 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: Premature ovary insufficiency is frequent after chemotherapy/radiotherapy in cancer patients. Ovarian tissue (OT) cryopreservation and later retransplantation, the routine method in Europe, has recently been implemented at the first center in China. We investigated the protective effect of the antioxidant N-acetyl-l-cysteine (NAC) during the decisive freezing-thawing steps. Read More

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http://dx.doi.org/10.1080/13697137.2018.1554644DOI Listing
January 2019
1 Read

Mediterranean diet is associated with bone mineral density and muscle mass in postmenopausal women.

Climacteric 2019 Jan 21:1-7. Epub 2019 Jan 21.

a Gynecological Endocrinology Unit, Division of Endocrinology , Hospital de Clínicas de Porto Alegre (HCPA) , Porto Alegre , Brazil.

Purpose: This study aimed to investigate the association between the Mediterranean diet (MD), body composition, and bone mineral density (BMD) in postmenopausal women.

Methods: In this cross-sectional study, 105 apparently healthy postmenopausal women aged between 45 and 65 years were included. BMD, percentage body fat, and appendicular lean mass index (ALMI, appendicular lean mass/height squared) were assessed by dual-energy X-ray absorptiometry. Read More

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http://dx.doi.org/10.1080/13697137.2018.1529747DOI Listing
January 2019
2 Reads

Cerebrovascular reactivity after cessation of menopausal hormone treatment.

Climacteric 2019 Jan 21:1-8. Epub 2019 Jan 21.

e Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester , MN , USA.

Objective: Women who are currently using menopausal hormone therapy (MHT) have higher cerebrovascular reactivity when compared with postmenopausal women who are not taking MHT; however, the effect of cessation of MHT on cerebrovascular reactivity is not known. Given that MHT can have structural and activational effects on vascular function, this study was performed to characterize cerebrovascular reactivity following cessation of MHT in women at low risk for cerebrovascular disease.

Methods: Cerebrovascular reactivity was measured in a subset of women from the Kronos Early Estrogen Prevention Study (KEEPS) 3 years after cessation of the study drug (oral conjugated equine estrogen, transdermal 17β-estradiol, or placebo [PLA]). Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1538340DOI Listing
January 2019
12 Reads

Keeping the pelvic floor healthy.

Climacteric 2019 Jan 17:1-6. Epub 2019 Jan 17.

a School of Rehabilitation, Faculty of Medicine , University of Montreal, Research Centre of the Institut Universitaire de Gériatrie de Montréal , Montreal , QC, Canada.

Female pelvic floor muscles form a diaphragm that spans the entire pelvic cavity. They consist of the fibers of the coccygeus and the levator ani muscles, the latter of which is composed of five parts. Together with their fascia, the pelvic floor muscles provide support for the urethra, the vagina, and the rectum and constrict the urethral, vaginal, and anal orifices. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1552934DOI Listing
January 2019
8 Reads

Factors related to muscle strength in postmenopausal women aged younger than 65 years with normal vitamin D status.

Climacteric 2019 Jan 17:1-5. Epub 2019 Jan 17.

b Department of Obstetrics and Gynaecology , Hospital Universitario Lozano-Blesa, University of Zaragoza Faculty of Medicine , Zaragoza , Spain.

Objective: The study aimed to determine the impact of age, age at menopause, body mass index (BMI), and lumbar and hip bone mineral density (BMD) on muscle strength in young postmenopausal women with normal vitamin D levels.

Methods: This was a cross-sectional study performed in 392 postmenopausal women aged <65 years with normal serum 25-hydroxyvitamin D levels (≥30 ng/ml) and no physical disabilities. The following variables were recorded: age, age at menopause, BMI, BMD (measured by dual-energy X-ray absorptiometry [DXA] scanning and expressed as lumbar and hip T-scores), and dominant hand grip strength (measured with a digital dynamometer). Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1554645DOI Listing
January 2019
6 Reads

Association of mindfulness and stress with menopausal symptoms in midlife women.

Climacteric 2019 Jan 17:1-6. Epub 2019 Jan 17.

a Division of General Internal Medicine, Menopause & Women's Sexual Health Clinic , Mayo Clinic , Rochester , MN , USA.

Purpose: Midlife women frequently experience stress and menopausal symptoms. Mindfulness is thought to mitigate stress by avoiding emotional reactivity and ruminative thinking. We sought to assess the association of mindfulness and stress on menopausal symptoms among midlife women. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551344DOI Listing
January 2019
6 Reads

Higher intake of dietary n-3 PUFA and lower MUFA are associated with fewer menopausal symptoms.

Climacteric 2019 Jan 10:1-7. Epub 2019 Jan 10.

a Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.

Objective: This study aimed to investigate the association between dietary fat quality and menopausal symptoms.

Methods: We carried out a cross-sectional study with 393 Iranian postmenopausal women. Dietary intakes and menopausal symptoms were assessed, using a validated food frequency questionnaire and a menopausal rating scale (MRS) questionnaire, respectively. Read More

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http://dx.doi.org/10.1080/13697137.2018.1547700DOI Listing
January 2019
1 Read

Endometriosis: seeking optimal management in women approaching menopause.

Climacteric 2019 Jan 10:1-10. Epub 2019 Jan 10.

k Department of Biomedicine and Prevention , Università degli studi di Roma 'Tor Vergata' , Rome , Italy.

The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably poor attention. Disease management is problematic for these women due to increased contraindications regarding hormonal treatment and the possibility for malignant transformation, considering the increased cancer risk in patients with a long-standing history of the disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1549213DOI Listing
January 2019
8 Reads

Hormone replacement therapy and prevention of chronic conditions.

Climacteric 2019 Jan 10:1-4. Epub 2019 Jan 10.

c Department of Obstetrics and Gynecology, Policlinico Gemelli , Rome , Italy.

Nowadays, postmenopausal women are largely undertreated. Analysis of conflicting results among different studies suggests that hormone replacement therapy (HRT) can prevent osteoporosis and cardiovascular disease in symptomatic, early postmenopausal women. In fact, climacteric symptoms are related to an increased risk of chronic conditions, including hypertension and cardiovascular disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551347DOI Listing
January 2019
5 Reads

Benefit-risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John's wort in breast cancer patients.

Climacteric 2019 Jan 10:1-9. Epub 2019 Jan 10.

e Medical Service , Schaper & Brümmer GmbH & Co. KG , Salzgitter , Germany.

Endocrine therapy in breast cancer survivors can cause severe 'climacteric' symptoms, which may compromise therapy adherence. To determine whether such symptoms can be treated with herbal medication containing black cohosh in the form of isopropanolic Cimicifuga racemosa extract (iCR) alone or in fixed combination with St John's wort (Hypericum perforatum [HP]) (iCR + HP), a systematic literature search was conducted. Results were viewed in relation to experimental data and metabolism of endocrine therapies. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551346DOI Listing
January 2019
2 Reads

Association of VDR and OPG gene polymorphism with osteoporosis risk in Chinese postmenopausal women.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

a Department of Gynecology and Obstetrics , Beijing Hospital, National Center of Gerontology , Beijing , China.

Aims: The underlying mechanisms of vitamin D receptor (VDR) and osteoprotegerin (OPG) genetic variation associated with bone mineral density and osteoporosis remain uncertain. This study aimed to investigate the association of VDR and OPG gene polymorphism as well as gene-gene interaction and their haplotype combination with the risk of osteoporosis.

Methods: Polymerase chain reaction restriction fragment length polymorphism was carried out for single nucleotide polymorphism (SNP) detection. Read More

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http://dx.doi.org/10.1080/13697137.2018.1554643DOI Listing
January 2019
2 Reads

Atherosclerotic disease and cardiovascular risk factors in postmenopausal breast cancer survivors: a case-control study.

Climacteric 2019 Jan 9:1-6. Epub 2019 Jan 9.

a Department of Gynecology and Obstetrics , Sao Paulo State University - UNESP , Sao Paulo , Brazil.

Objective: Breast cancer (BC) therapies and the longevity that the women achieve imply a higher cardiovascular risk. The aim of the study was to evaluate the frequency of atherosclerotic disease and its association with cardiovascular risk factors in postmenopausal breast cancer survivors (BCS) compared to postmenopausal women without BC.

Methods: In this study, 96 women with BC (case group) were compared to 192 women without BC (control group), age range 45-75 years. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551345DOI Listing
January 2019
2 Reads

The etiology and management of recurrent urinary tract infections in postmenopausal women.

Authors:
C Jung L Brubaker

Climacteric 2019 Jan 9:1-8. Epub 2019 Jan 9.

a Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery , University of California San Diego , La Jolla , CA , USA.

Urinary tract infections (UTIs) are one of the most common infections and affect up to 50% of women in their lifetime, with almost half of these women experiencing a recurrence in 6-12 months. Menopause predisposes women to recurrent UTI (rUTI), as normally lower levels of estrogen lead to changes in the urogenital epithelium and subsequently urogenital microbiome. The recently discovered urobiome is now known to have different compositions in both healthy and unhealthy bladders, including a role in the pathophysiology of rUTI, and may be a therapeutic target for prevention and treatment options for rUTI. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551871DOI Listing
January 2019
3 Reads

Assessment and hormonal management of osteoporosis.

Authors:
F Trémollieres

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

a Menopause Center, Hôpital Paule de Viguier , University Hospital of Toulouse , Toulouse , France.

Postmenopausal osteoporosis is a frequent health issue in women. Because osteoporosis-related fractures cause a significant increase in mortality and morbidity, it is clinically important to identify as soon as possible women at increased risk for future fracture so that preventive measures can be instituted. At the beginning of menopause, evaluation of the subsequent risk of fracture is not so easy. Read More

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http://dx.doi.org/10.1080/13697137.2018.1555582DOI Listing
January 2019
3 Reads

Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549214DOI Listing
January 2019
2 Reads

Maintaining sexual function after pelvic floor surgery.

Authors:
S Jha

Climacteric 2019 Jan 7:1-6. Epub 2019 Jan 7.

a Department of Urogynaecology , Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield , UK.

Sexual dysfunction in women with prolapse and incontinence is well documented in the literature, but the impact of treatment, particularly surgical correction, remains very limited and confusing. Age, on the other hand, has been shown to be an independent risk factor for deteriorating sexual function, with all aspects of the sexual function (i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1551870DOI Listing
January 2019
9 Reads

Assessment of sexual activity and menopausal symptoms in middle-aged Chinese women using the Menopause Rating Scale.

Climacteric 2019 Jan 7:1-7. Epub 2019 Jan 7.

a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Dalian Medical University , Dalian , P.R. of China.

Objectives: This study aimed to assess sexual activity and menopausal symptoms in middle-aged Chinese women and to correlate this with their vaginal maturation status (VMS).

Methods: 120 women aged 45-60 years were assigned to four groups: premenopause (Pre-M), perimenopause (Peri-M), early postmenopause (Post-EM), and late postmenopause (Post-LM). The menopausal symptoms were assessed using the Menopause Rating Scale. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1547702DOI Listing
January 2019
8 Reads

Lower expression of prestin and MYO7A correlates with menopause-associated hearing loss.

Climacteric 2019 Jan 7:1-9. Epub 2019 Jan 7.

d Peking University First Hospital , Beijing Shi , China.

Objective: This study aimed to test the hearing function and to investigate the effect of estrogen on prestin and MYO7A expression in hair cells of the cochlea in ovariectomized rats.

Study Design: We compared the hearing function systematically in normal female Sprague-Dawley rats and in ovariectomized rats with or without exogenous β-estradiol administration by auditory brainstem response measurements and distortion product otoacoustic emissions. In addition, a correlation analysis between the functional parameters and cochlear histology was carried out. Read More

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http://dx.doi.org/10.1080/13697137.2018.1547698DOI Listing
January 2019
2 Reads

Circulating androgen levels before and after oophorectomy in premenopausal and postmenopausal women.

Climacteric 2019 Jan 7:1-6. Epub 2019 Jan 7.

a Department of Obstetrics and Gynecology, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.

Objective: This study aimed to determine the effect of oophorectomy on baseline serum levels of androgens and estrogens in premenopausal and postmenopausal women.

Methods: Fourteen premenopausal and 10 postmenopausal women underwent total hysterectomy and bilateral oophorectomy for benign disease of the uterus. Serum levels of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A), testosterone (T), dihydrotestosterone (DHT), 5α-androstane-3α,17β-diol-17β-glucuronide (3α-diol G), estrone (E), estradiol (E), and sex hormone-binding globulin (SHBG) were measured by highly specific immunoassays prior to surgery and 2 weeks afterward. Read More

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http://dx.doi.org/10.1080/13697137.2018.1535584DOI Listing
January 2019
2 Reads

Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women.

Climacteric 2019 Feb 2;22(1):97-104. Epub 2019 Jan 2.

b Genomics of Bone Metabolism Laboratory , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.

Objective: This study aimed to investigate the association of seven single nucleotide polymorphisms (SNPs) on the RMND1, CCDC170, and ESR1 genes with osteoporosis or hip fracture in a postmenopausal Mexican population.

Methods: We included a group of 400 postmenopausal women from the Health Workers Cohort Study from the Mexican Institute of Social Security. As a replication sample, we recruited 423 postmenopausal women from the National Institute of Rehabilitation. Read More

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http://dx.doi.org/10.1080/13697137.2018.1538339DOI Listing
February 2019
3 Reads

Fibroid management in premenopausal women.

Climacteric 2019 Feb 2;22(1):27-33. Epub 2019 Jan 2.

b Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique , Université Catholique de Louvain , Brussels , Belgium.

Uterine fibroids are the most common tumors affecting premenopausal women, responsible for bleeding, pain, and reduced quality of life. When symptomatic, their management mainly involves surgery, which is all too often radical (hysterectomy). While surgical options sparing the uterus (hysteroscopic and laparoscopic myomectomy) and other non-surgical approaches do indeed exist, drug-based therapies are associated with lower costs and morbidity rates. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549216DOI Listing
February 2019
3 Reads

The existence and potential of germline stem cells in the adult mammalian ovary.

Climacteric 2019 Feb 2;22(1):22-26. Epub 2019 Jan 2.

b MRC Centre for Reproductive Health , Queen's Medical Research Institute, University of Edinburgh , Edinburgh , UK.

It has long been accepted that the complement of follicles within the ovary is formed before birth in humans, or shortly after birth in rodents, and that no follicles are formed thereafter. This follows entry of all oogonia into meiosis in fetal life, with no remaining germ stem cells in the ovary, in contrast to the presence of spermatogonia in the testis. This has been brought back into debate in recent years, following the demonstration of isolation of cells expressing both germline and stem markers from the postnatal ovary in several species, including humans. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543264DOI Listing
February 2019
1 Read

Vaginal atrophy across the menopausal age: results from the ANGEL study.

Climacteric 2019 Feb 2;22(1):85-89. Epub 2019 Jan 2.

c Department of Obstetrics, Gynecology and Pediatrics, Institute of Obstetrics and Gynecology , University of Pisa , Pisa , Italy.

Objectives: This study aimed to investigate the prevalence of vaginal atrophy (VA) in women across the menopausal age.

Methods: A multicenter cross-sectional investigation was performed on 747 females, 40-55 years of age, in 30 outpatient public services across the nation. The VA diagnosis was based on the combination of patient sensation of vaginal dryness, an objective sign of VA, and pH >5. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1529748DOI Listing
February 2019
2 Reads

The neurokinin B pathway in the treatment of menopausal hot flushes.

Climacteric 2019 Feb 21;22(1):51-54. Epub 2018 Dec 21.

b Department of Obstetrics and Gynaecology , University of Glasgow , Glasgow , UK.

Hot flushes remain a debilitating aspect of menopause, disrupting daytime activities and sleep, and may last for years. Estrogen replacement is an effective treatment, but takes time to become maximally effective and is contraindicated in a significant proportion of women, most notably after breast cancer. Effective, non-hormonal therapies are therefore required. Read More

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http://dx.doi.org/10.1080/13697137.2018.1540564DOI Listing
February 2019
2 Reads

Surgical management of pelvic organ prolapse.

Climacteric 2018 Dec 21:1-7. Epub 2018 Dec 21.

m Caremeau University Hospital , Nimes , France.

Despite pelvic organ prolapse being a universal problem experienced in nearly 50% of parous women, the surgical management of vaginal prolapse remains an enigma to many, with wide variation in the rates and types of intervention performed. As part of the 6th International Consultation on Incontinence (ICI) our committee, charged with producing an evidence-based report on the surgical management of prolapse, produced a pathway for the surgical management of prolapse. The 2017 ICI surgical management of prolapse evidence-based pathway will be presented and summarized. Read More

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http://dx.doi.org/10.1080/13697137.2018.1551348DOI Listing
December 2018
4 Reads

The prevalence of urinary incontinence.

Authors:
I Milsom M Gyhagen

Climacteric 2018 Dec 21:1-6. Epub 2018 Dec 21.

a Department of Obstetrics & Gynaecology , Sahlgrenska Academy at Gothenburg University , Gothenburg , Sweden.

The reported prevalence of urinary incontinence (UI) among women varies widely in different studies due to the use of different definitions, the heterogenicity of different study populations, and population sampling procedures. Population studies from numerous countries have reported that the prevalence of UI ranged from approximately 5% to 70%, with most studies reporting a prevalence of any UI in the range of 25-45%. Prevalence figures increase with increasing age, and in women aged ≥70 years more than 40% of the female population is affected. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543263DOI Listing
December 2018
3 Reads

Sexual dysfunction in perimenopausal women based on a national epidemiological survey in China.

Climacteric 2018 Dec 21:1-5. Epub 2018 Dec 21.

a Department of Obstetrics & Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Science , Beijing Shi , China.

Objective: Sexual function in premenopausal and postmenopausal women was diverse in previous related literature, and national epidemiological data are rare. The aim of this study was to investigate female sexual dysfunction (FSD) variation in the transition of menopause based on a national epidemiological survey in China.

Methods: A national epidemiological survey on female sexual function was conducted from February 2014 to January 2016 in mainland China. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1547699DOI Listing
December 2018
8 Reads

Investigation of pelvic floor disorders.

Climacteric 2018 Dec 21:1-6. Epub 2018 Dec 21.

a Urogynecology Department , National and Kapodistrian University of Athens, 'Alexandra' Hospital , Athens , Greece.

Pelvic floor disorders (PFDs) are a common and complex problem encompassing a broad spectrum of conditions such as urinary incontinence, voiding difficulties, pelvic organ prolapse, anal incontinence, and chronic pelvic pain. The initial assessment of women with PFDs is based on a detailed and focused history and a holistic clinical evaluation of the pelvic floor. Other investigations may be used in clinical practice for the determination of the pathophysiology and the severity of the PFDs. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549217DOI Listing
December 2018
4 Reads

Menopause research in Latin America.

Climacteric 2019 Feb 21;22(1):17-21. Epub 2018 Dec 21.

b Departamento de Medicina Interna Sur, Facultad de Medicina , Universidad de Chile , Santiago , Chile.

For 15 years, the Collaborative Group for Research of the Climacteric in Latin America (REDLINC) has been conducting research on several topics including age of menopause, metabolic syndrome, quality of life and climacteric symptoms, sexual dysfunction, poor quality of sleep and insomnia, and use of menopausal hormone therapy (MHT) in the general population and among gynecologists. Examples of data to have emerged for this region include the age of menopause (49 years), a high prevalence of metabolic syndrome (42.9%), and a new waist circumference cut-off value for the Latin American population (88 cm). Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1540565DOI Listing
February 2019
10 Reads

Optimizing quality of life through sex steroids by their effects on neurotransmitters.

Climacteric 2019 Feb 20;22(1):55-59. Epub 2018 Dec 20.

a Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine , University of Pisa , Pisa , Italy.

Menopause-related symptoms such as hot flushes, night sweats, weight gain, and decreased sexual functioning all have negative impacts on quality of life and affect daily activities such as sleep, work, and leisure activities. During the menopause transition, neurotransmitters, neuropeptides, and neurosteroids undergo important changes as a consequence of the failure of gonadal hormone production, at a time when many central nervous system activities deteriorate. Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic branching, myelination, and other important mechanisms of neural plasticity. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543265DOI Listing
February 2019
7 Reads

Overview of perimenopausal contraception.

Authors:
J Bitzer

Climacteric 2019 Feb 18;22(1):44-50. Epub 2018 Dec 18.

a Frauenklinik , Universitätsspital Basel , Basel , Switzerland.

The perimenopause is accompanied by important biological and psychosocial changes. The choice of contraceptive methods for women in the perimenopause, none of which is limited by age alone, will depend on the efficacy, safety, tolerability, and potential benefit of each method in relation to the biopsychosocial profile of the individual woman. Copper intrauterine devices are highly effective in the typical user and are a very safe method with, in general, good tolerability but are of limited use in women with heavy menstrual bleeding and subserous myomata. Read More

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http://dx.doi.org/10.1080/13697137.2018.1540566DOI Listing
February 2019
3 Reads

Adjuvant endocrine therapy side-effects among postmenopausal breast cancer patients in Malaysia.

Climacteric 2018 Dec 17:1-7. Epub 2018 Dec 17.

a Faculty of Pharmacy , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.

Objective: This study was conducted to determine the prevalence and severity of menopausal symptoms and their associated risk factors among postmenopausal breast cancer patients receiving adjuvant endocrine therapy.

Methods: Postmenopausal breast cancer patients on endocrine therapy were recruited at three hospitals in Malaysia. Presence and severity of menopausal symptoms were determined using the Menopause Rating Scale. Read More

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http://dx.doi.org/10.1080/13697137.2018.1540563DOI Listing
December 2018
3 Reads

Hormone therapy and breast cancer: risk communication and the 'perfect storm'.

Authors:
R L Reid

Climacteric 2019 Feb 17;22(1):13-16. Epub 2018 Dec 17.

a Division of Reproductive Endocrinology and Infertility , Queen's University , Kingston , ON , Canada.

Many factors are considered when a woman estimates her personal risk of breast cancer. Common to most decisions are four separate influences that have convinced the public and many health-care providers that breast cancer is the greatest concern for menopausal women and that menopausal hormone therapy (MHT) is generally responsible. Historically there have been well-documented situations in which big pharma and doctors have not put patient interests first. Read More

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http://dx.doi.org/10.1080/13697137.2018.1527305DOI Listing
February 2019
9 Reads

Treatment of moderate to severe dyspareunia with intravaginal prasterone therapy: a review.

Climacteric 2019 Feb 17;22(1):65-72. Epub 2018 Dec 17.

d Department of Obstetrics, Gynecology, and Reproductive Sciences , University of California , San Francisco , CA , USA.

The loss of sex steroids (e.g. estradiol, dehydroepiandrosterone [DHEA], progesterone) that causes menopause commonly affects a woman's general health and produces bothersome physical changes that may interfere with normal sexual and genitourinary functioning. Read More

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http://dx.doi.org/10.1080/13697137.2018.1535583DOI Listing
February 2019
3 Reads

Menopause-specific Quality of Life Questionnaire: factor and Rasch analytic approach.

Climacteric 2019 Feb 11;22(1):90-96. Epub 2018 Dec 11.

b Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

Objective: The study aimed to assess the psychometric properties of the Menopause-specific Quality of Life Questionnaire (MENQOL) in Serbian climacteric women.

Methods: Two hundred mid-aged (40-65 years) women filled out a general sociodemographic and medical questionnaire, the MENQOL, the Short Form-36 questionnaire (SF-36), and Beck's Depression Inventory (BDI). The MENQOL was translated according to recommended methodology and its psychometric properties (internal consistency, discriminant, construct and criterion validity, factor and Rasch analyses) were assessed. Read More

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http://dx.doi.org/10.1080/13697137.2018.1535585DOI Listing
February 2019
4 Reads

Analysis of factors that influence the quality of sexual life of climacteric women in China.

Climacteric 2019 Feb 30;22(1):73-78. Epub 2018 Nov 30.

a Department of Gynecology and Obstetrics , Peking University People's Hospital , Beijing , P. R. China.

Objective: The study aimed to identify the factors associated with the sexual lives of perimenopausal and postmenopausal women in China.

Methods: A total of 426 participants were approached about this study from May 2012 to August 2013. In total, 252 cases were included in this study. Read More

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http://dx.doi.org/10.1080/13697137.2018.1514002DOI Listing
February 2019
3 Reads

Impact of micronized progesterone on body weight, body mass index, and glucose metabolism: a systematic review.

Climacteric 2018 Nov 27:1-14. Epub 2018 Nov 27.

a Department of Obstetrics and Gynecology , University of Bern , Bern , Switzerland.

In women, body weight increases with age. Often menopausal hormone therapy (MHT) is blamed for enhancing this effect. In recent years, the debate on bioidentical MHT including micronized progesterone (MP) has increased. Read More

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http://dx.doi.org/10.1080/13697137.2018.1514003DOI Listing
November 2018
4 Reads

What should guide our patient management of vulvovaginal atrophy?

Authors:
M Shapiro

Climacteric 2019 Feb 19;22(1):38-43. Epub 2018 Nov 19.

a Department of Family and Community Medicine , University of Toronto , Toronto , ON , Canada.

Genitourinary syndrome of menopause including vulvovaginal atrophy is commonly experienced by postmenopausal women, reducing their quality of life. The aim of this review is to assess current treatment options within the framework of recent management guidelines. Recommendations include use of treatments addressing both symptoms and the underlying pathophysiology, and proactive patient discussion. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1527306DOI Listing
February 2019
11 Reads

An epidemiologic study of pelvic organ prolapse in postmenopausal women: a population-based sample in China.

Climacteric 2019 Feb 19;22(1):79-84. Epub 2018 Nov 19.

a Department of Gynecology and Obstetrics, Peking Union Medical College Hospital , Peking Union Medical College , Beijing , People's Republic of China.

Objective: This study aimed to assess the prevalence and factors associated with symptomatic pelvic organ prolapse (POP) in a representative sample of postmenopausal Chinese women.

Methods: A total of 20,008 postmenopausal Chinese women were recruited to this cross-sectional study between February 2014 and March 2016. The prevalence of symptomatic POP, defined as any stage II or higher POP resulting in symptoms, was assessed using questionnaires and physical examinations. Read More

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http://dx.doi.org/10.1080/13697137.2018.1520824DOI Listing
February 2019
5 Reads

Optimizing quality of life in perimenopause: lessons from the East.

Authors:
X Wang S Ran Q Yu

Climacteric 2019 Feb 8;22(1):34-37. Epub 2018 Nov 8.

a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.

As global life expectancy improves, women are expected to spend more than one-third of their lives in the status of menopause. In China, many women suffer from menopausal symptoms during this period, which impacts their well-being and quality of life. However, most Chinese women simply endure menopausal symptoms. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1506435DOI Listing
February 2019
13 Reads