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    Effects of black cohosh and estrogen on core body and tail-skin temperatures in ovariectomized rats by telemetric monitoring with dual thermistor probes.
    Climacteric 2018 Jan 11:1-7. Epub 2018 Jan 11.
    e Department of Physiology and Pathophysiology, School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.
    Objectives: To investigate the effects of black cohosh and estrogen on the temperature in ovariectomized rats, the core body temperature (CBT) and tail-skin temperature (TST) were simultaneously monitored and the relationship between these two temperatures was explored.

    Methods: Twenty-four female Sprague-Dawley rats aged 8 weeks were randomly divided into four groups: sham-operated (SHAM), ovariectomized (OVX), OVX treated with estradiol valerate (OVX + E), and OVX treated with isopropanolic black cohosh extract (OVX + ICR). Rats were sham-operated or ovariectomized and were implanted with telemetry transmitters with dual thermistor probes. Read More

    The effect of programmed exercise over anxiety symptoms in midlife and older women: a meta-analysis of randomized controlled trials.
    Climacteric 2018 Jan 8:1-9. Epub 2018 Jan 8.
    a Facultad de Medicina , Universidad de Zaragoza & Instituto Aragonés de Ciencias de la Salud (IACS) , Zaragoza , Spain.
    We aimed to perform a systematic review and meta-analysis in order to clarify the effect of programmed exercise over mild-to-moderate anxiety symptoms (ASs) in midlife and older women. A structured search of PubMed, Medline, Web of Science, Scopus, Embase, Cochrane Library, Scielo, and the US, UK and Australian Clinical Trials databases (from inception through July 27, 2017) was performed, with no language restriction using the following terms: 'anxiety', 'anxiety symptoms', 'exercise', 'physical activity', 'menopause', and 'randomized controlled trial' (RCTs) in mid-aged and older women. We assessed RCTs that compared the effect of exercise for at least 6 weeks versus no intervention over ASs as outcome (as defined by trial authors). Read More

    Clinicopathological and prognostic significance of platelet count in patients with ovarian cancer.
    Climacteric 2018 Feb 12;21(1):60-68. Epub 2017 Dec 12.
    a Department of Gynecology and Obstetrics , The People's Hospital of Three Gorges University/The First People's Hospital of Yichang , Yichang , China.
    Aim: Increasing evidence indicates that platelet count is a useful biomarker of long-term outcomes in patients with ovarian cancer. However, the prognostic value of platelet count in patients with ovarian cancer remains controversial. We therefore conducted a meta-analysis aimed to investigate the prognostic role of the platelet count in patients with ovarian cancer. Read More

    Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats.
    Climacteric 2018 Feb 12;21(1):75-81. Epub 2017 Dec 12.
    a Universidade Federal de São Paulo. Escola Paulista de Medicina , Departamento de Morfologia e Genética , São Paulo , Brasil.
    Aim: To evaluate the combined effects of streptozotocin-induced diabetes (Di) and ovariectomy in the articular cartilage of rats.

    Methods: Forty adult female Wistar rats were ovariectomized (OVX) or sham-operated. After recovery from surgery, the animals were assigned randomly into four groups: OVX control (OVX-C); OVX treated with 10 µg/kg/day of 17β-estradiol (OVX-E); sham-operated subjected to Di (Sham-Di); and OVX subjected to Di (OVX-Di). Read More

    Predictors of malignancy in endometrial polyps: study of 421 women with postmenopausal bleeding.
    Climacteric 2018 Feb 8;21(1):82-87. Epub 2017 Dec 8.
    a Institute of Cancer and Genomic Sciences , University of Birmingham , Birmingham , UK.
    Objective: There is lack of consensus as whether benign-looking endometrial polyps should be removed in postmenopausal women. To help inform clinical practice, this study was conducted to quantify the prevalence and identify the predictors of hyperplasia and cancer in polyps.

    Methods: The data of 2625 consecutive women attending a postmenopausal bleeding clinic were collected prospectively in a UK teaching hospital between January 2011 and December 2015. Read More

    The futile case of the aging ovary: is it mission impossible? A focused review.
    Climacteric 2018 Feb 8;21(1):22-28. Epub 2017 Dec 8.
    a Department of Reproductive Medicine , Gynaecworld , Mumbai , India.
    Despite immense and impressive progress in the field of reproductive medicine, little has been achieved in terms of replenishing aged ovaries and improving their reproductive outcome. Age causes irreversible damage to human eggs in terms of quantity as well as quality. Nature probably designed women to reproduce best in their twenties and thirties. Read More

    Efficacy and safety evaluation of Cimicifuga foetida extract in menopausal women.
    Climacteric 2018 Feb 4;21(1):69-74. Epub 2017 Dec 4.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China.
    Objective: The aim of this study was to evaluate the efficacy and safety of long-term treatment with Cimicifuga foetida extract in menopausal women.

    Methods: A prospective, randomized, controlled clinical trial was conducted. A total of 96 early postmenopausal women were randomly assigned to three groups: group A received 1 mg estradiol valerate daily plus 4 mg medroxyprogesterone acetate on days 19-30; group B received 1 mg estradiol valerate daily plus 100 mg micronized progesterone on days 19-30; group C received 100 mg C. Read More

    Pregnancy history, coronary artery calcification and bone mineral density in menopausal women.
    Climacteric 2018 Feb 30;21(1):53-59. Epub 2017 Nov 30.
    b Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester , MN , USA.
    Objective: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women.

    Methods: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4-9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Read More

    Depressive symptoms and their risk factors in midlife women in the Middle East: a systematic review.
    Climacteric 2018 Feb 30;21(1):13-21. Epub 2017 Nov 30.
    e Women's Health Research Program, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.
    Introduction: Women may experience different menopausal symptoms across different cultures around the world. The purpose of this study was to determine the prevalence and contributing factors of depression in midlife women in the Middle East.

    Methods: Electronic databases including PubMed, Medline, PsycINFO, CINAHL, Web of Science, SCOPUS, and Google scholar were searched. Read More

    Endometriosis resembling endometrial cancer in a postmenopausal patient.
    Climacteric 2018 Feb 23;21(1):88-91. Epub 2017 Nov 23.
    a 1st Department of Obstetrics and Gynecology , Warsaw Medical University , Warsaw , Poland.
    Endometriosis occurs in 2-4% of postmenopausal women. There have been a few reports of endometriosis in women in whom neither history nor diagnostic imaging indicated the presence of this disease, either at reproductive age or after menopause. A case is described of an 84-year-old patient with extensive deep pelvic endometriosis imitating advanced neoplastic process. Read More

    The use and discontinuation of hormone replacement therapy in women in South China.
    Climacteric 2018 Feb 23;21(1):47-52. Epub 2017 Nov 23.
    a School of Medicine , Women's Hospital, Zhejiang University , Hangzhou , PR China.
    Objective: The use of hormone replacement therapy (HRT) started later in China than in European countries. The purpose of the present study was to investigate HRT patterns and reasons for the initiation and discontinuation of HRT among women in South China.

    Methods: A telephone survey about menopausal status, the use of HRT, reasons for HRT discontinuation and duration of HRT treatment was conducted in 2014. Read More

    Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women.
    Climacteric 2018 Feb 9;21(1):40-46. Epub 2017 Nov 9.
    a Department of Obstetrics and Gynecology , Severance Hospital, Yonsei University College of Medicine , Seoul , Republic of Korea.
    Objective: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. Read More

    Menopause, lung function and obstructive lung disease outcomes: a systematic review.
    Climacteric 2018 Feb 6;21(1):3-12. Epub 2017 Nov 6.
    a Allergy and Lung Health Unit, Centre for Epidemiology & Biostatistics , Melbourne School of Population & Global Health, The University of Melbourne , Melbourne , VIC , Australia.
    Background: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies.

    Objective: To systematically summarize the literature regarding the impact of menopause status on respiratory health outcomes.

    Methods: PubMed was searched systematically to identify population-based studies investigating the associations between menopause status and respiratory outcomes including asthma, chronic obstructive pulmonary disease (COPD), respiratory symptoms and lung function. Read More

    Prediction of age at menopause in women with polycystic ovary syndrome.
    Climacteric 2018 Feb 6;21(1):29-34. Epub 2017 Nov 6.
    d Endocrine Research Center, Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , I.R. Iran.
    Objective: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later.

    Methods: In total, 1162 women aged 20-50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria. Read More

    Screening for general anxiety disorders in postmenopausal women with symptomatic pelvic organ prolapse.
    Climacteric 2018 Feb 2;21(1):35-39. Epub 2017 Nov 2.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , PR China.
    Objective: This study aimed to investigate the prevalence of general anxiety disorder (GAD) among postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify its associated factors.

    Methods: A cross-sectional study was conducted among postmenopausal women with symptomatic POP. Sociodemographic data and medical histories were obtained. Read More

    Metabolic syndrome in menopause and associated factors: a meta-analysis.
    Climacteric 2017 Dec 24;20(6):583-591. Epub 2017 Oct 24.
    a State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology , The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing Medical University , Nanjing , China.
    Objective: Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease and diabetes. Menopause is associated with an increased risk for MetS. The purpose of this meta-analysis is to better understand the relationship between MetS and menopause. Read More

    No increased death toll for long-term menopausal hormone therapy.
    Climacteric 2017 Dec 23;20(6):531-532. Epub 2017 Oct 23.
    a Sackler School of Medicine , Tel-Aviv University , Tel-Aviv , Israel.
    It took many years since the initial publication of data from the Women's Health Initiative (WHI) study until further analyses and additional accumulated clinical information allowed realization of the full scope of its results. At first, the focus was on morbidity, mainly the slightly higher incidence of cardiovascular events and breast cancer cases among postmenopausal hormone users. Then, the age factor became evident, and the good safety profile of hormone therapy in healthy women initiating treatment near menopause and using it for up to 10 years eased the previous concerns. Read More

    Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?
    Climacteric 2017 Dec 17;20(6):505-509. Epub 2017 Oct 17.
    a Department of Investigative Medicine , Imperial College London , London , UK.
    Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Read More

    Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis.
    Climacteric 2017 Dec 16;20(6):522-527. Epub 2017 Oct 16.
    c Department of Nutrition , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
    Aim: There is conflicting evidence regarding the effects of omega-3 fatty acids on bone turnover markers in postmenopausal women. Thus, we systematically reviewed the efficacy of omega-3 fatty acids by conducting a meta-analysis of available randomized controlled trials.

    Methods: PubMed, Embase, Cochrane Library and Scopus were searched in December 2016. Read More

    FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women.
    Climacteric 2017 Dec 5;20(6):577-582. Epub 2017 Oct 5.
    d Department of Neurology, Faculty of Medicine Universitas Indonesia , Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
    Objective: To determine the role of anthropometric measurement, menopausal symptoms and biochemical marker changes as screening methods for mild cognitive impairment (MCI) in postmenopausal women Methods: A cross-sectional study included 282 postmenopausal women in Jakarta, further classified into two groups, with and without MCI. Some related variables such as age, body mass index (BMI), duration of menopause, vasomotor symptoms, hormone levels such as follicle stimulating hormone (FSH), luteinizing hormone, leptin, estradiol, and cognitive status, were assessed and analyzed.

    Results: The FSH levels significantly correlated with MCI incidence (p = 0. Read More

    The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women.
    Climacteric 2017 Dec 22;20(6):552-557. Epub 2017 Sep 22.
    a Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology , Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
    Objective: The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women.

    Methods: A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level >5. Read More

    Foot problems in older women.
    Climacteric 2017 Dec 21;20(6):518-521. Epub 2017 Sep 21.
    a Department of Obstetrics and Gynecology, Faculty of Health Sciences , University of Witwatersrand , Parktown, Johannesburg , South Africa.
    Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated with other co-morbid diseases of the foot. Read More

    The influence of unilateral oophorectomy on the age of menopause.
    Climacteric 2017 Dec 21;20(6):540-544. Epub 2017 Sep 21.
    a Department of Gynecology , Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark.
    Objective: To determine the age of menopause after premenopausal unilateral oophorectomy (UO) and to establish whether UO at a young age leads to menopause at a younger age than if UO occurs at an older age.

    Methods: A cohort of 28 731 women, of whom 17 781 (62%) were menopausal, was investigated. Information on menopause was obtained from self-reported questionnaires. Read More

    Influence of menopausal symptoms on perceived work ability among women in a Nigerian University.
    Climacteric 2017 Dec 21;20(6):558-563. Epub 2017 Sep 21.
    b Department of Family Medicine , Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC) , Ile-Ife , Nigeria.
    Objectives: This study investigated the menopausal symptoms experienced by women of menopausal age in Ekiti State, Nigeria and the influence on their perceived work ability.

    Method: A descriptive cross-sectional research design was employed and the study was conducted among 200 working-class women aged 45 years and above who had experienced at least 12 continuous months of amenorrhea in Ekiti State University, Ado Ekiti. A semi-structured questionnaire adapted from the Greene Climacteric Scale and the work ability index was used to assess menopausal symptoms and work ability, respectively. Read More

    17β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
    Climacteric 2017 Dec 21;20(6):571-576. Epub 2017 Sep 21.
    c Department of Pathology and Oncology , University of Occupational and Environmental Health, School of Medicine , Kitakyushu , Japan.
    Objective: The aim of this report was to evaluate the impact of hormone replacement therapy (HRT) on lymphocytic infiltration of the endometrium in postmenopausal women.

    Method: This study included 58 Japanese patients who had undergone hysterectomy at the University Hospital of Occupational and Environmental Health, Japan. Before surgery, nine patients had received 17β-estradiol (E2), 0. Read More

    Nordic walking increases circulating VEGF more than traditional walking training in postmenopause.
    Climacteric 2017 Dec 17;20(6):533-539. Epub 2017 Sep 17.
    a Department of Medicine and Aging Science , University "G. d'Annunzio", Chieti-Pescara , Chieti , Pescara , Italy.
    Objectives: Nordic walking (NW) is widely practiced by postmenopausal women. Its effects are peculiar owing to the involvement of more muscle groups than in traditional walking training (WT). Since mechanical load promotes secretion of vascular endothelial growth factor (VEGF) from both skeletal muscle and muscle endothelium, the aim of the study was to compare the effect of NW and WT on VEGF levels. Read More

    Native tissue repair versus mesh repair in pelvic organ prolapse surgery.
    Climacteric 2017 Dec 5;20(6):510-517. Epub 2017 Sep 5.
    d 2nd Department of Obstetrics and Gynecology , Hippokratio University Hospital , Thessaloniki , Greece.
    In pelvic organ prolapse, the anatomical defects develop at the anterior (anterior vaginal wall), the posterior (posterior vaginal wall) and the apical (the uterus/cervix or the apex of the vagina, vaginal vault or cuff scar after hysterectomy) compartments. These defects occur in more than one compartment. Treatment of pelvic organ prolapse is commonly surgical, aiming to restore the anatomy of structures supporting the pelvic organs. Read More

    Effects of soy isoflavones on the concentration of hyaluronic acid in the vagina of type 1 diabetic rats.
    Climacteric 2017 Dec 2;20(6):564-570. Epub 2017 Sep 2.
    a Department of Morphology and Genetics , Paulista School of Medicine/Federal University of São Paulo, EPM/UNIFESP , São Paulo , Brazil.
    Objective: To assess the effects of isoflavones and 17β-estradiol on the vaginal epithelium extracellular matrix and hyaluronic acid (HA) in the diabetic rat model.

    Methods: Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups of ten animals each: GI, sham ovariectomized control animals; GII, sham ovariectomized control diabetic animals; GIII, control ovariectomized rats receiving propylene glycol vehicle; GIV, control ovariectomized diabetic animals receiving propylene glycol vehicle; GV, diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage); GVI, ovariectomized diabetic rats treated with estrogen (17β-estradiol, 10 mg/kg, subcutaneously). Treatment took place over 30 consecutive days. Read More

    Experience of menopause in women with inflammatory bowel disease: pilot study.
    Climacteric 2017 Dec 17;20(6):545-551. Epub 2017 Aug 17.
    a Department of Obstetrics & Gynecology, Department of Medicine, Faculty of Medicine and Dentistry , University of Alberta , Edmonton , Canada.
    Objective: Inflammatory bowel diseases (IBD) are debilitating chronic intestinal diseases requiring extensive medical intervention. Little is known how IBD symptoms and treatments affect menopause experience and quality of life. The study's goal was to investigate the relationship between IBD and menopause. Read More

    Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
    Climacteric 2017 Oct 14;20(5):402-413. Epub 2017 Aug 14.
    i Professor Emeritus, Reproductive Biology , Case Western Reserve University , Cleveland , OH , USA.
    The US Preventive Services Task Force (USPSTF) Draft Recommendation statement on Menopausal Hormone Therapy: Primary Prevention for Chronic Diseases, released in May 2017, perpetuates a major disconnect between the primary population affected, women within roughly 10 years of menopause, and the data cited. Furthermore, major elements of the evidence relied upon have been misinterpreted or misstated, particularly in regard to coronary heart disease and breast cancer, for which there is no statistically significant evidence of harm. As currently drafted, the recommendations reiterate the USPSTF statements of 2012, 2005 and 2002, and will perpetuate egregious harm to the public health. Read More

    Age-related differences in left ventricular structure and function between healthy men and women.
    Climacteric 2017 Oct 8;20(5):476-483. Epub 2017 Aug 8.
    a Department of Physiology and Health, Cardiff School of Sport , Cardiff Metropolitan University , Cardiff , UK.
    Objectives: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group.

    Methods: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Read More

    Abnormal uterine bleeding in perimenopause.
    Climacteric 2017 Oct 7;20(5):414-420. Epub 2017 Aug 7.
    b Professor of Medical Education and Gynaecology, Lead for Reproductive and Maternal Medicine, School of Medicine , University of Glasgow , Glasgow , UK.
    Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Read More

    Dependency of cardiovascular risk on reproductive stages and on age among middle-aged Chinese women.
    Climacteric 2017 Oct 3;20(5):484-490. Epub 2017 Aug 3.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
    Objective: To assess the 10-year cardiovascular risk in middle-aged Chinese women living in the same community and the impact of reproductive aging and age.

    Methods: This was a cross-sectional study in the Yuetan Community of Beijing. Data on lifestyle habits, prevalence and treatment of chronic diseases with significance for cardiovascular disease (CVD) development were collected by interview. Read More

    Increased detection of co-morbidities with evaluation at a dedicated adult Turner syndrome clinic.
    Climacteric 2017 Oct 28;20(5):442-447. Epub 2017 Jul 28.
    a Menopause Unit, Monash Medical Centre , Monash Health , Clayton , VIC , Australia.
    Objectives: Turner syndrome (TS), resulting from complete/partial X chromosomal monosomy, is associated with multiple co-morbidities and increased mortality. Although multidisciplinary management is recommended, TS women's health care is sub-optimal. This study evaluates a multidisciplinary adult TS service. Read More

    Factors associated with complementary and alternative medicine use among women at midlife.
    Climacteric 2017 Oct 8;20(5):421-426. Epub 2017 Jul 8.
    a School of Kinesiology and Health Science , York University , Toronto , ON , Canada.
    Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. Read More

    Lichen sclerosus in women: a review.
    Climacteric 2017 Aug 29;20(4):339-347. Epub 2017 Jun 29.
    b Lower Genital Tract Disease Unit , Centro Hospitalar de São João , Porto , Portugal.
    Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Read More

    The UK breast screening program - what you need to know.
    Climacteric 2017 Aug 29;20(4):313-320. Epub 2017 Jun 29.
    a Radiology Department , Norfolk and Norwich University Hospital , Norwich , UK.
    Breast cancer is the most commonly diagnosed cancer in women with a lifetime risk of 1 in 8 in the UK. The disease is associated with considerable morbidity and mortality. The UK breast screening program has been in place for almost 30 years and has evolved with improved diagnostic imaging. Read More

    Monurelle Biogel® vaginal gel in the treatment of vaginal dryness in postmenopausal women.
    Climacteric 2017 Oct 28;20(5):467-475. Epub 2017 Jun 28.
    h Zambon SpA , Bresso , Milan , Italy.
    Objectives: To evaluate efficacy, tolerability and safety of Monurelle Biogel® vaginal gel for treatment of vaginal dryness.

    Methods: Multicenter, national, randomized, controlled vs. no-treatment, open-label study. Read More

    The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
    Climacteric 2017 Aug 16;20(4):321-330. Epub 2017 Jun 16.
    d Department of Gynecology , University of La Sabana Clinic , Bogota , Colombia.
    Objectives: To evaluate the efficacy and safety of estriol for the treatment of vulvovaginal atrophy in postmenopausal women.

    Methods: A systematic literature review was performed. We searched the following electronic databases: Medline, Cochrane, Embase, Lilacs, CINHAL and Google Scholar. Read More

    Analysis of differential genetic expression in endometrial polyps of postmenopausal women.
    Climacteric 2017 Oct 16;20(5):462-466. Epub 2017 Jun 16.
    a Department of Obstetrics and Gynecology , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , SP , Brazil.
    Objectives: To evaluate the expression of four genetic markers (PTEN, BCL2, MLH1, and CTNNB1), linked to endometrial carcinogenesis, in endometrial polyps of patients with and without postmenopausal bleeding in order to determine whether symptomatic endometrial polyps have a genetic phenotype similar to that of endometrial cancer.

    Methods: Samples were obtained hysteroscopically from endometrial polyps of postmenopausal patients, and the expression of genetic markers involved in the pathogenesis of endometrial cancer (PTEN, BCL2, MLH1, and CTNNB1) was analyzed. The expression of these markers was then compared between patients with and without symptoms, which was characterized as postmenopausal bleeding. Read More

    Sleep duration and midlife women's health.
    Climacteric 2017 Dec 14;20(6):528-530. Epub 2017 Jun 14.
    a Sackler Faculty of Medicine , Tel-Aviv University , Tel-Aviv , Israel.
    Sleep is mandatory for life and therefore any sleep deprivation or disruption might carry ill-health outcomes. The optimal night's sleep duration seems to be around 7 h, as too little sleep and too much sleep have been found to be associated with a variety of changes in well-being, physical and psychological parameters. This mini-review enlightens the potential health consequences of sleep disturbance relevant to menopause and midlife women's health. Read More

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