44,470 results match your criteria Cleft Palate-Craniofacial Journal[Journal]


The Effectiveness of an International Cleft Mission Model in Asia: An Update.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S23-S28

Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Background: Cleft lip/palate is a congenital craniofacial anomaly affecting patients physically and psychosocially and has contributed to the global burden of surgical disease, especially in underprivileged areas. For 20 years, Noordhoff Craniofacial Foundation (NCF) and the Chang Gung Craniofacial Center (CGCFC) have carried out missions to these areas. Rather than implementing short-term missions that lack proper follow-up care, the team has provided an effective, long-term, and multidisciplinary approach for the treatment of patients with cleft lip/palate. Read More

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January 2019
1 Read

Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN.

FASEB J 2018 Dec 12:fj201800926R. Epub 2018 Dec 12.

School of Biological Sciences, Seoul National University, Seoul, South Korea; and.

SRC-family kinases (SFKs) have been implicated in Alzheimer's disease (AD), but their mode of action was scarcely understood. Here, we show that LYN plays an essential role in amyloid β (Aβ)-triggered neurotoxicity and tau hyperphosphorylation by phosphorylating Fcγ receptor IIb2 (FcγRIIb2). We found that enzyme activity of LYN was increased in the brain of AD patients and was promoted in neuronal cells exposed to Aβ 1-42 (Aβ). Read More

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December 2018
1 Read

Systematic deletions in the cellobiohydrolase (CBH) Cel7A from the fungus reveal flexible loops critical for CBH activity.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.

Glycoside hydrolase family 7 (GH7) cellulases are some of the most efficient degraders of cellulose, making them particularly relevant for industries seeking to produce renewable fuels from lignocellulosic biomass. The secretome of the cellulolytic model fungus Trichoderma reesei contains two GH7s, termed TrCel7A and TrCel7B. Despite having high structural and sequence similarities, the two enzymes are functionally quite different. Read More

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December 2018

Parental-Caregivers Perceptions Questionnaire (P-CPQ): translation and evaluation of psychometric properties of the French version of the questionnaire.

BMC Oral Health 2018 Dec 11;18(1):211. Epub 2018 Dec 11.

Universite Paris Diderot, Paris, France.

Background: The Parental-Caregivers Perceptions Questionnaire (P-CPQ) is a measure of parental/caregivers' perceptions of the impact of children's oral health on quality of life. The aim of the study was evaluate the psychometric properties of the French version of the P-CPQ.

Method: The original P-CPQ was developed in English language and has 31 items divided into four sub-scales. Read More

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December 2018

Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis.

Cleft Palate Craniofac J 2018 Dec 11:1055665618815400. Epub 2018 Dec 11.

2 Division of Plastic and Reconstructive Surgery, Centre for Craniofacial Care and Research, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Introduction:: Assessment of cranial dysmorphism in sagittal synostosis is often subjective but objective measures can be applied. These include cephalic index (CI) and midsagittal vector analysis (MSVA).

Objective:: To assess discriminant validity, construct validity, and responsiveness of CI and MSVA measured from computed tomography (CT) in patients with sagittal synostosis. Read More

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December 2018

Quantitative Evaluation of Cephalometric Radiographs of Patients With Hemifacial Microsomia.

Cleft Palate Craniofac J 2018 Dec 11:1055665618813453. Epub 2018 Dec 11.

4 Department of Oral and Maxillofacial Surgery, Toya Kyokai Hospital, Toyako-cho, Abuta-gun, Japan.

Objective:: To clarify the morphological characteristics of hemifacial microsomia (HFM) by quantitative analysis of cephalometric radiographs.

Design:: Retrospective study of imaging data.

Setting:: Imaging data were obtained from the records of Sapporo Medical University Hospital. Read More

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December 2018

Endoscopic endonasal resection of symptomatic Rathke cleft cysts: clinical outcomes and prognosis.

Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More

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December 2018
1 Read

Prenatal diagnosis of cleft lip and cleft lip palate - a case series.

Med Ultrason 2018 Dec;20(4):531-535

University of Medicine and Pharmacy Tirgu Mures, Romania.

Aim: Orofacial clefts comprise cleft lip (CL) or cleft lip-palate (CLP) and are the most frequently encountered malformation of the facial region, accounting for approximately 1-2.2/1,000 live births. The aim of this study was to reveal the particularities regarding the prenatal diagnosis of orofacial clefts in a series of 11 cases diagnosed in a tertiary center. Read More

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December 2018

Regional anesthesia to ameliorate postoperative analgesia outcomes in pediatric surgical patients: an updated systematic review of randomized controlled trials.

Local Reg Anesth 2018 15;11:91-109. Epub 2018 Nov 15.

Department of Anesthesiology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA,

Regional anesthesia is becoming increasingly popular among anesthesiologists in the management of postoperative analgesia following pediatric surgery. The main objective of this review was to systematically evaluate the last 5 years of randomized controlled trials on the role of regional anesthesia techniques in alleviating postoperative pain associated with various pediatric surgical procedures. Forty studies on 2,408 pediatric patients were evaluated. Read More

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November 2018

OSC10: Observation of the Teeth Position in Cleft Lip and Palate Patients using Three-Dimensional Assessment.

J Indian Prosthodont Soc 2018 Oct;18(Suppl 1):S11

Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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October 2018

Ultrasound-guided trigeminal nerve block and its comparison with conventional analgesics in patients undergoing faciomaxillary surgery: Randomised control trial.

Indian J Anaesth 2018 Nov;62(11):871-875

Department of Dentistry, AIIMS, Patna, Bihar, India.

Background And Aims: Ultrasound (USG)-guided injection in pterygopalatine fossa is an indirect approach to block the trigeminal nerve. Trigeminal nerve block for maxillofacial surgeries may provide preemptive analgesia, reduce opioid consumption and opioid-related adverse effects.

Methods: In this randomised, prospective double-blind study, 60 American Society of Anesthesiologists I/II patients, within the age group of 18-60 years scheduled for faciomaxillary surgery (fracture/pathological lesion of maxilla or mandible and cleft lip), were recruited. Read More

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November 2018
1 Read

Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Years Follow-up of Treatment Protocol.

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

Plastic & Reconstructive Surgery, and Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. Email:

Background: The treatment plan for cleft lip and palate varies among centers, and requires long-term evaluation of its final outcome.

Methods: A consecutive patients born in 1994 to 1996 were reviewed. Inclusion criteria were complete unilateral cleft lip and palate, receiving all treatment procedures in the team and continuous follow-ups until 20 years of age. Read More

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November 2018

Combined Primary Cleft Lip and Palate Repair: Is It Safe?

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY.

Background: Single-stage primary cleft lip and palate (PCLP) repair is controversial in the United States, and most patients are treated with a staged approach. In this study, early postoperative complications of the single-stage approach as compared to primary cleft lip (PCL) or primary cleft palate (PCP) alone were evaluated. This study represents the largest cohort of patients undergoing combined cleft lip and palate repair. Read More

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December 2018

Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.

J Mol Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Julius-von-Sachs-Platz 2, D-97082, Wuerzburg, Germany. Electronic address:

Interleukin-5 (IL-5) is a T2 cytokine involved in many aspects of eosinophil life. Eosinophilic granulocytes play a pathogenic role in the progression of atopic diseases, such as allergy, asthma and atopic dermatitis and hypereosinophilic syndromes. Here, eosinophils upon activation degranulate leading to the release of proinflammatory proteins and mediators stored in intracellular vesicles termed granula thereby causing local inflammation, which when persisting leads to tissue damage and organ failure. Read More

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December 2018
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Anti-biofilm and anti-adherence properties of novel cyclic dipeptides against oral pathogens.

Bioorg Med Chem 2018 Nov 29. Epub 2018 Nov 29.

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420, rue de la Terrasse, Québec, QC G1V 0A6, Canada. Electronic address:

Microorganisms embedded in a biofilm are significantly more resistant to antimicrobial agents and the defences of the human immune system, than their planktonic counterpart. Consequently, compounds that can inhibit biofilm formation are of great interest for novel therapeutics. In this study, a screening approach was used to identify novel cyclic dipeptides that have anti-biofilm activity against oral pathogens. Read More

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November 2018

Velopharyngeal insufficiency after maxillary advancement in patients with cleft palate - a survey of risk assessment in the United Kingdom and Ireland.

Br J Oral Maxillofac Surg 2018 Dec 7. Epub 2018 Dec 7.

Northern and Yorkshire Cleft Lip and Palate Service, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Great George St, Leeds LS1 3EX.

Patients with cleft lip and palate may require orthognathic surgery to correct severe impairments in midfacial growth. Maxillary advancement in this group, however, is linked to deterioration in velopharyngeal function (VPF), and it is not clear how cleft teams assess this risk. We therefore surveyed surgeons from 15 cleft units who provide orthognathic treatment, to gain an understanding of current practice in the UK and Ireland. Read More

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December 2018

Secondary alveolar bone grafting in cleft lip and palate: A comparative analysis of donor site morbidity in different age groups.

J Craniomaxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Department of Pediatric Surgery (Head: Professor Ewa Sawicka), Institute of Mother and Child Warsaw, Poland.

Introduction: There is no consensus regarding the optimal timing for secondary alveolar bone grafting for clefts defects. We aimed to investigate the potential correlation between the age of patients during surgery, donor site symptoms, surgical time and hospitalization following this procedure.

Material And Methods: The outcome of 195 consecutive alveolar bone grafting procedures among different age groups (mean: 7. Read More

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November 2018

Comment on Malmborn, Becker, and Klintö: Problems With Reliability of Speech Variables for Use in Quality Registries for Cleft Lip and Palate-Experiences From the Swedish Cleft Lip and Palate Registry, CPCJ 2018.

Authors:
Anette Lohmander

Cleft Palate Craniofac J 2018 Dec 9:1055665618817654. Epub 2018 Dec 9.

1 Division of Speech & Language Pathology, CLINTEC, Karolinska Institutet, Stockholm, Sweden.

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December 2018

A Programmable Expander for Patients With Cleft Lip and Palate.

Cleft Palate Craniofac J 2018 Dec 9:1055665618815398. Epub 2018 Dec 9.

3 Children's Hospital Los Angeles (CHLA), University of Southern California, Los Angeles, CA, USA.

This report describes a method to expand cleft segments of patients with cleft lip and palate prior to the secondary alveolar bone graft (ABG) using a reprogrammable nickel titanium expander. The expander can be reprogrammed with electric current to the desired width for each patient and delivers a gradual slow expansive spring force that expands and aligns the segments without further adjustments. Reprogramming the expander eliminates the need for multiple appliances and reduces chair time and patient appointments. Read More

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December 2018

Clinical Outcomes Utilizing a "Modified Latham" Appliance for Presurgical Infant Orthopedics in Patients With Unilateral Complete Cleft Lip and Palate.

Cleft Palate Craniofac J 2018 Dec 9:1055665618816892. Epub 2018 Dec 9.

1 Division of Plastic and Reconstructive Surgery, Johns Hopkins All Children's Hospital, St Petersburg, FL, USA.

Presurgical infant orthopedic manipulation is utilized prior to cleft lip/nasal repair to facilitate a gingivoperiosteoplasty (GPP) and primary nasolabial repairs. The Latham dentomaxillary advancement appliance uses a screw that must be tightened daily to approximate the cleft segments in unilateral complete clefts. Our cleft center has been utilizing a "modified Latham" appliance since 1987, including an orthodontic elastic power chain to close the gap in a shorter amount of time. Read More

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December 2018

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.

Nucleic Acids Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.

During protein synthesis, ribosomes discriminate chirality of amino acids and prevent incorporation of D-amino acids into nascent proteins by slowing down the rate of peptide bond formation. Despite this phenomenon being known for nearly forty years, no structures have ever been reported that would explain the poor reactivity of D-amino acids. Here we report a 3. Read More

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December 2018
2 Reads
9.112 Impact Factor

Dento-skeletal characteristics of cleft patients with missing teeth.

Clin Cosmet Investig Dent 2018 8;10:237-244. Epub 2018 Nov 8.

Advanced Education Program in Orthodontics and Dentofacial Orthopedics, UMKC School of Dentistry, Kansas City, MO, USA.

Objective: The objective of this study was to compare the cephalometric skeletal and dental characteristics of unilateral complete cleft lip and palate (UCCLP) subjects with and without missing teeth.

Design: A retrospective records review was conducted for patients who are being treated at the cleft lip and palate (CLP) clinics in the College of Dentistry.

Methods: Ninety-six consecutive records of non-syndromic UCCLP subjects were recruited (33 subjects without missing teeth, 50 subjects with only one missing tooth, and 13 subjects with two or more missing teeth). Read More

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November 2018

Probing the interface structure of adhering cells by contrast variation neutron reflectometry.

Langmuir 2018 Dec 5. Epub 2018 Dec 5.

Cellular adhesion is a central element in tissue mechanics, biological cell-cell signaling, and cell motility. In this context, the cell-substrate distance has been investigated in the past by studying natural cells and biomimetic cell models adhering on solid substrates. The amount of water in the membrane substrate gap, however, is difficult to determine. Read More

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December 2018
3 Reads

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Authors:
Robert Roskoski

Pharmacol Res 2018 Nov 30. Epub 2018 Nov 30.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC, 28742-8814, United States. Electronic address:

Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle. The concentrations of the CDKs are generally constant, but their activities are controlled by the oscillation of the cyclin levels during each cell cycle. Additional CDK family members play significant roles in a wide range of activities including gene transcription, metabolism, and neuronal function. Read More

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November 2018
1 Read

Intravenous Lidocaine Administered as Twice Daily Bolus and Continuous Infusion for Intractable Cancer Pain and Wound Care Pain.

J Palliat Med 2018 Dec 1. Epub 2018 Dec 1.

3 Spectrum Health Medical Group , Palliative Care Medicine, Grand Rapids, Michigan.

Introduction: Intravenous lidocaine is an option for intractable pain caused by advancing cancer and wound care. We report a case of intractable cancer pain and wound care pain managed with concurrent use of lidocaine administered as a twice daily intravenous bolus in addition to continuous intravenous infusion.

Case Description: A 31-year-old male with rapidly progressing locally advanced squamous cell cancer affecting the gluteal area developed extensive painful and purulent ulcerating wounds affecting the coccyx, superior gluteal cleft, and buttocks. Read More

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December 2018
4 Reads

New Technique for Closure of Alveolar Cleft With Umbilical Cord Stem Cells.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic and Reconstructive Surgery, Hospital de San José, Fundación Universitaria de Ciencias de la Salud, Servicio Cirugía Plástica Estética y Reconstructiva - Pabellón Arcadio Forero.

This article presents the case of a newly born female patient with a cleft of the primary palate (alveolar cleft), with an in utero diagnosis of the described cleft, from whom umbilical cord stem cells are obtained and cryopreserved. The patient is managed with nasoalveolar molding, and at 5 months of age, she is taken to surgery for cheiloplasty and gingivoperiostioplasty with umbilical cord stem cells. A radiographic and CT follow-up is carried out on the described cleft. Read More

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November 2018
2 Reads

A Novel Approach for the Reconstruction of Premaxilla by Archwise Distraction in Bilateral Cleft Lip and Palate.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthodontics, Faculty of Dentistry, Okan University, Istanbul, Turkey.

Interdental distraction osteogenesis has been introduced as a successful treatment protocol for repairing large clefts. In this article, a new method for reconstruction of the premaxilla in 2 bilateral cleft lip and palate patients is introduced. The aim was to distract the lateral segments through the curve of the dental arch, achieve complete closure of the gaps, and use the premaxilla as a bone graft. Read More

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November 2018

The rhinologist's role in the management of rathke's cleft cysts.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 16. Epub 2018 Nov 16.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadephia, Pennsylvania, USA.

Purpose Of Review: To review the recent literature regarding the growing role of rhinologists and otolaryngologists with neurosurgeons in the joint multidisciplinary team approach for managing patients with Rathke's cleft cysts (RCC).

Recent Findings: The transnasal endoscopic approach to the skull base has become relatively mainstream for surgical treatment of RCCs. Suprasellar lesions, especially those that are purely suprasellar, are associated with higher recurrence rates, though an extended approach may improve dissection and access and therefore aid in lesion removal. Read More

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November 2018
1 Read

NTN1 gene was risk to NSCLO among Han Chinese Population.

Oral Dis 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of cleft lip and palate, West China Hospital of Stomatology, Sichuan University.

Objective: Genome wide association studies (GWAS) found NTN1, NOG and the region between CREBBP and ADCY9 were risks to non-syndromic cleft lip with or without cleft palate (NSCL/P). However, the association of single nucleotide polymorphisms (SNPs) in these genes with NSCL/P in Western China is unknown.

Subjects And Methods: We selected seven SNPs in NTN1, NOG and between CREBBP and ADCY9, then performed transmission disequilibrium test (TDT), parent-of-origin effect and sliding window haplotype analysis to test the associations among 302 NSCL/P case-parent trios from Western Han Chinese. Read More

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December 2018
1 Read

United Reference Method for three-dimensional treatment evaluation.

Prog Orthod 2018 Dec 3;19(1):47. Epub 2018 Dec 3.

Head of Orthodontic Division and Chair of the Postgraduate Orthodontic Program, Department of Orthodontics, University of Campania Luigi Vanvitelli, Via L. De Crecchio 6, 80138, Naples, Italy.

Background: Reproducible and descriptive Three-dimensional treatment evaluation can enhance future treatment based on realistic results. So, the purpose of this study was to describe a new method for three-dimensional treatment evaluation showing how to use fully-automated craniofacial superimposition of CBCT records combined with reference system to obtain descriptive and comparable results. This new method was named United Reference Method (URM). Read More

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December 2018

Untreated incomplete isolated cleft palate: cadaveric findings.

Anat Sci Int 2018 Nov 30. Epub 2018 Nov 30.

Seattle Science Foundation, 550 17th Avenue, Suite 600, Seattle, WA, 98122, USA.

Isolated cleft palate without cleft lip is a rare deformity. Cleft lip and cleft palate can sometimes develop in combination with a syndrome due to genetic causes. Affected patients have morbidity through life from birth and experience comprehensive treatment for such clefts including surgery. Read More

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November 2018
1 Read

The refinement of the median tubercle of cleft lip.

Authors:
Jyotsna Murthy

Indian J Plast Surg 2018 May-Aug;51(2):131-136

Department of Plastic Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Aim: Repair of cleft lip aims to bring symmetry and provide normal aesthetics for the lip. Several techniques have been employed; however, the finer aspect of median lip tubercle has not been emphasised in cleft lip repair.

Materials And Methods: We have modified cleft lip repair, both unilateral and bilateral, preserving all the tissues of the median tubercle to provide normal-looking median tubercle of the lip. Read More

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December 2018
1 Read

Localizing proton-mediated inhibitory feedback at the retinal horizontal cell-cone synapse with genetically-encoded pH probes.

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Vision Science Graduate Program, University of California, Berkeley

Lateral inhibition in the vertebrate retina depends on a negative feedback synapse between horizontal cells (HCs) and rod and cone photoreceptors. A change in pH is thought to be the signal for negative feedback, but its spatial profile in the synaptic cleft is unknown. Here we use 3 different membrane proteins, each fused to the same genetically-encoded pH-sensitive GFP (pHluorin), to probe synaptic pH in retina from transgenic zebrafish () of either sex. Read More

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November 2018
6.344 Impact Factor

Cement distribution patterns in osteoporotic vertebral compression fractures with intravertebral cleft: effect on therapeutic efficacy.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, People's Republic of China. Electronic address:

Objective: To determine cement distribution patterns on therapeutic efficacy after percutaneous vertebroplasty (PVP) treatment of osteoporotic vertebral compression fractures (OVCFs) with intravertebral cleft (IVC).

Methods: Patients who were treated with PVP for single OVCFs with IVC and met this study's inclusion criteria were retrospectively reviewed. The follow-up period was at least 2 years. Read More

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November 2018

Phenylephrine, a small molecule, inhibits pectin methylesterases.

Biochem Biophys Res Commun 2018 Nov 27. Epub 2018 Nov 27.

Department of Agricultural Chemistry (BK21 plus), Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju, 52828, Republic of Korea. Electronic address:

Pectin methylesterases (PMEs) catalyze pectin demethylation and facilitate the determination of the degree of methyl esterification of cell wall in higher plants. The regulation of PME activity through endogenous proteinaceous PME inhibitors (PMEIs) alters the status of pectin methylation and influences plant growth and development. In this study, we performed a PMEI screening assay using a chemical library and identified a strong inhibitor, phenylephrine (PE). Read More

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November 2018
2 Reads

Philtrum reconstruction in unilateral cleft lip repair.

Authors:
S Naidoo K-W Bütow

Int J Oral Maxillofac Surg 2018 Nov 27. Epub 2018 Nov 27.

Facial Cleft Deformity Clinic, Department of Maxillofacial and Oral Surgery, University of Pretoria, Pretoria, South Africa; Life Wilgers Hospital, Pretoria, South Africa.

The philtrum is an important aesthetic structure in the midface. A number of philtrum reconstruction techniques have been advocated for secondary cleft lip revision procedures. Conventional surgical management involves end-to-end orbicularis oris muscle approximation during primary cleft lip repair, often resulting in a flat lip appearance that requires secondary revision surgery at a later stage. Read More

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November 2018

Schizencephaly: A Review of 734 Patients.

Pediatr Neurol 2018 Oct 8;87:23-29. Epub 2018 Aug 8.

Pediatric Oncology Institute/GRAACC, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Schizencephaly is a rare congenital cerebral malformation associated with serious neurological manifestations. The number of studies regarding schizencephaly is limited.

Methods: We conducted a literature review and extracted data from the case reports. Read More

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October 2018
1 Read

Osteogenesis of Multipotent Progenitor Cells using the Epigallocatechin Gallate-Modified Gelatin Sponge Scaffold in the Rat Congenital Cleft-Jaw Model.

Int J Mol Sci 2018 Nov 29;19(12). Epub 2018 Nov 29.

Department of Oral Implantology, Osaka Dental University, 8-1, Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.

Cost-effective and functionalized scaffolds are in high demand for stem-cell-based regenerative medicine to treat refractory bone defects in craniofacial abnormalities and injuries. One potential strategy is to utilize pharmacological and cost-effective plant polyphenols and biocompatible proteins, such as gelatin. Nevertheless, the use of chemically modified proteins with plant polyphenols in this strategy has not been standardized. Read More

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November 2018
3 Reads

Quality of life and mastication in denture wearers and cleft lip and palate adults.

Braz Oral Res 2018 Nov 29;32:e113. Epub 2018 Nov 29.

Pontifícia Universidade Católica do Rio Grande do Sul - PUC-RS, Dental School, Porto Alegre, RS, Brazil.

The impact of oral rehabilitation on masticatory function and oral health-related quality of life (OHRQoL) may vary with the experience of the individual with tissue loss. Our hypothesis is that patient-centered outcomes vary among adults who have experienced large defects in the maxilla due to congenital or acquired conditions even after oral rehabilitation to restore aesthetics and function. This study compared OHRQoL, perceived masticatory ability, maximum bite force (MBF), and symptoms of pain and depression among subjects with acquired (edentulous maxilla) and congenital (cleft lip and palate) loss of oral tissues in the maxilla after dental treatment. Read More

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November 2018
1 Read

Special education use in elementary school by children with nonsyndromic orofacial clefts.

Birth Defects Res 2018 Dec 5. Epub 2018 Dec 5.

School of Dentistry and UNC Craniofacial Center, University of North Carolina, Chapel Hill, North Carolina.

Background: Children with nonsyndromic orofacial clefts (NS OFCs) may require exceptional children's (EC) services for academic delays. We examined EC service use of children with and without NS OFCs in NC in elementary school.

Methods: We included 559 children with NS OFCs and 6,822 children without birth defects who had NC educational records. Read More

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December 2018
2 Reads

Reductive Nitric Oxide Coupling at a Dinickel Core: Isolation of a Key cis-Hyponitrite Intermediate en route to N2O Formation.

Angew Chem Int Ed Engl 2018 Dec 5. Epub 2018 Dec 5.

Georg-August-Universität, Institut für Anorganische Chemie, Tammannstrasse 4, 37077, Göttingen, GERMANY.

Reductive coupling of nitric oxide (NO) to give N2O is an important reaction in the global nitrogen cycle. Here, a dinickel(II) dihydride complex 1 that releases H2 upon substrate binding and serves as a dinickel(I) scaffold is shown to reductively couple two molecules of NO within the bimetallic cleft. The resulting hyponitrite complex 2 features an unprecedented cis-[N2O2]2- binding mode that has been computationally proposed as a key intermediate in flavodiiron nitric oxide reductases (FNORs). Read More

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December 2018

Russell-Silver syndrome with cleft palate: a case report.

Oral Maxillofac Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi, 755-8505, Japan.

Background: Russell-Silver syndrome (RSS) is characterized by intrauterine growth retardation, short stature without postnatal catch-up growth, and an inverted triangular face with relative macrocephaly. There have been few case reports of RSS with cleft palate, in which perioperative problems such as difficult intubation due to trismus and impossibility to wear a mouth gag due to growth failure of the mandible were described. The case of a female RSS patient with cleft palate who underwent palatoplasty is reported. Read More

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December 2018
2 Reads

PseudoGTPase domains in p190RhoGAP proteins: a mini-review.

Biochem Soc Trans 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, U.S.A.

Pseudoenzymes generally lack detectable catalytic activity despite adopting the overall protein fold of their catalytically competent counterparts, indeed 'pseudo' family members seem to be incorporated in all enzyme classes. The small GTPase enzymes are important signaling proteins, and recent studies have identified many new family members with noncanonical residues within the catalytic cleft, termed pseudoGTPases. To illustrate recent discoveries in the field, we use the p190RhoGAP proteins as an example. Read More

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December 2018
1 Read

Early Weight Gain in Infants With Cleft Lip and Palate Treated With and Without Nasoalveolar Molding: A Retrospective Study.

Cleft Palate Craniofac J 2018 Dec 4:1055665618815396. Epub 2018 Dec 4.

1 Department of Orthodontics, Oregon Health & Science University, Portland, OR, USA.

Objective:: To assess weight gain of infants with cleft lip and/or palate (CL ± P) treated with nasoalveolar molding (NAM).

Design:: Retrospective, case-control chart review.

Setting:: Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon. Read More

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December 2018

A New Paradigm in Cleft Lip Procedural Excellence: Creation and Preliminary Digital Validation of a Lifelike Simulator.

Plast Reconstr Surg 2018 Nov;142(5):1300-1304

Boston, Mass. From the Department of Plastic and Oral Surgery, the Simulator Program (SIMPeds), and the Department of Anesthesiology, Critical Care, and Pain Medicine, Division of Critical Care Medicine, Boston Children's Hospital; and Harvard Medical School.

Simulation is becoming an increasingly important tool for hands-on surgical education in a no-risk environment. Cleft lip repair is a common procedure where precise technique is needed to achieve optimal outcome, making it an ideal candidate for simulation. A digital simulated patient with a typical unilateral complete cleft lip and alveolus was constructed using existing three-dimensional imaging studies. Read More

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November 2018
1 Read

Structural studies of a glycoside hydrolase family 3 β-glucosidase from the model fungus Neurospora crassa.

Acta Crystallogr F Struct Biol Commun 2018 Dec 26;74(Pt 12):787-796. Epub 2018 Nov 26.

Department of Molecular Sciences, Swedish University of Agricultural Sciences, PO Box 7015, SE-750 07 Uppsala, Sweden.

The glycoside hydrolase family 3 (GH3) β-glucosidases are a structurally diverse family of enzymes. Cel3A from Neurospora crassa (NcCel3A) belongs to a subfamily of key enzymes that are crucial for industrial biomass degradation. β-Glucosidases hydrolyse the β-1,4 bond at the nonreducing end of cellodextrins. Read More

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December 2018
1 Read

Structures of endo-1,5-α-L-arabinanase mutants from Bacillus thermodenitrificans TS-3 in complex with arabino-oligosaccharides.

Acta Crystallogr F Struct Biol Commun 2018 Dec 26;74(Pt 12):774-780. Epub 2018 Nov 26.

Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

The thermostable endo-1,5-α-L-arabinanase from Bacillus thermodenitrificans TS-3 (ABN-TS) hydrolyzes the α-1,5-L-arabinofuranoside linkages of arabinan. In this study, the crystal structures of inactive ABN-TS mutants, D27A and D147N, were determined in complex with arabino-oligosaccharides. The crystal structures revealed that ABN-TS has at least six subsites in the deep V-shaped cleft formed across one face of the propeller structure. Read More

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December 2018
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Association between SATB2 gene polymorphism and cleft palate only risk in eastern Guangdong population and a meta-analysis.

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):101-107. Epub 2018 Nov 30.

The Second Affiliated Hospital of Shantou University Medical College, Department of Burns and Plastic Surgery & Cleft Lip and Palate Treatment Center Shantou, Guangdong, CN.

To characterize the associations between the cleft palate (CPO) and single nucleotide polymorphisms (SNPs) of special AT-rich sequence-binding protein 2 (SATB2). We recruited 241 CPO and performed a case-control study with 242 controls. Concurrently, 103 of the patients and their normal parents were recruited to perform a case-parent trio study. Read More

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November 2018
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The role of external aetiological factors in dental anomalies in non-syndromic cleft lip and palate patients.

Eur Arch Paediatr Dent 2018 Dec 3. Epub 2018 Dec 3.

Orthodontics Department, Central Research Institute of Dentistry and Maxillofacial Surgery, 119991, T. Frunze St., 16, Moscow, Russia.

Aim: The hypothesis tested was whether proper tooth development in cleft lip and palate (CLP) patients is affected by early orthopaedic treatment (EOT), primary surgical interventions and palatal defects after primary palatoplasty.

Methods: The prospective study groups comprised 369 CLP children (aged 11.0 ± 4. Read More

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December 2018
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Olfactory cleft proteome does not reflect olfactory performance in patients with idiopathic and postinfectious olfactory disorder: A pilot study.

Sci Rep 2018 Dec 3;8(1):17554. Epub 2018 Dec 3.

Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.

Technical advances including liquid chromatography-tandem mass spectrometry and its data analysis enable detailed proteomic analysis of the nasal mucus. Alterations of the nasal mucus proteome may provoke substantial changes of the nasal physiology and have already been associated with rhinologic diseases such as allergic rhinitis. This study was conducted as a pilot study to map the olfactory cleft proteome using current techniques for proteomic analysis. Read More

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December 2018