351,849 results match your criteria Clear Cell Sarcoma of the Kidney


Impaired Consciousness in the Emergency Department.

Eur Neurol 2018 Dec 12;80(3-4):179-186. Epub 2018 Dec 12.

Department of Neurology, Hospital of the Ludwig-Maximilians-University (LMU), Munich,

Background: The approach to unconscious patients in the emergency department (ED) is difficult, often depends on local resources and interests, and workup strategies often lack standardization. One reason for this is that data on causes, management, and outcome of patients who present to the ED with sudden onset unconsciousness of unknown cause is limited.

Objectives: This study was performed to analyze the causes of acute impaired consciousness in patients in an interdisciplinary ED. Read More

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December 2018
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Electroluminescence of intrashell transitions in Eu doped single ZnO nanowires.

Nanotechnology 2018 Dec 12. Epub 2018 Dec 12.

Institute for Solid State Physics, Friedrich-Schiller Universitat Jena, Max-Wien-Platz 1, D-07743 Jena, Jena, GERMANY.

Tunable nanoscale light emitters are essential to accomplish future multifunctional optoelectronic nano-devices. Here, we present an approach for achieving red electroluminescence from single ZnO nanowires implanted with Europium ions. The electroluminescence is emitted mainly from the end facets of ZnO nanowires at room temperature under the application of an AC voltage. Read More

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December 2018

Isolated Tear of the Teres Major Muscle.

Authors:
Katsumi Takase

Orthopedics 2018 Dec 11:1-3. Epub 2018 Dec 11.

Rotator cuff tears are frequently treated in daily clinical practice. However, there have been few reports of tears around the shoulder involving the latissimus dorsi and teres major muscles. The author reports the rare case of an isolated tear of the teres major muscle with symptom onset during ordinary sports activities without a clear traumatic mechanism. Read More

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December 2018

Femoral Nerve Palsy With Concomitant Patellar Dislocation in a Ballet Dancer.

Orthopedics 2018 Dec 11:1-3. Epub 2018 Dec 11.

Femoral nerve palsy with concomitant patellar dislocation is a rare clinical entity that has not previously been well documented. The authors present the case of a 16-year-old female ballet dancer who sustained a patellar dislocation with concomitant femoral nerve palsy. She experienced muscle weakness after the initial injury and developed neuropathic symptoms through the anterior left thigh. Read More

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December 2018

Inferring symmetric and asymmetric interactions between animals and groups from positional data.

PLoS One 2018 12;13(12):e0208202. Epub 2018 Dec 12.

Department of Mathematics and Statistics, University of Western Australia, Nedlands, Perth, WA, Australia.

Interactions between domestic and wild species has become a global problem of growing interest. Global Position Systems (GPS) allow collection of vast records of time series of animal spatial movement, but there is need for developing analytical methods to efficiently use this information to unravel species interactions. This study assesses different methods to infer interactions and their symmetry between individual animals, social groups or species. Read More

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December 2018

Can patients be trained to expect shared decision making in clinical consultations? Feasibility study of a public library program to raise patient awareness.

PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.

Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).

Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More

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December 2018

First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children.

PLoS One 2018 12;13(12):e0208328. Epub 2018 Dec 12.

Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.

Background: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20-25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.

Methodology: We conducted the first Phase IIb clinical trial assessing the safety, immunogenicity and efficacy of ChAd63 MVA ME-TRAP in 700 healthy malaria exposed children aged 5-17 months in a highly endemic malaria transmission area of Burkina Faso. Read More

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December 2018

Atorvastatin improves doxorubicin-induced cardiac dysfunction by modulating Hsp70, Akt and MAPK signalling pathways.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, The Second Hospital of Shandong University, Jinan, China.

Atorvastatin is a lipid-regulating drug that is commonly used in clinical practice and can stabilize plaques. Increasing evidence shows that statins have anti-heart failure effects, but their specific mechanism is not clear. The purpose of this study was to investigate the cardioprotective effects of atorvastatin on heart failure in rats and its mechanism. Read More

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December 2018
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Substantial differences in serum concentrations of psychoactive drugs measured in samples stored for two days or more on standard serum tubes versus serum tubes containing gel separators.

Ther Drug Monit 2018 Dec 11. Epub 2018 Dec 11.

Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

Background: Drugs may potentially adsorb to blood collection tubes containing gel separators in the pre-analytical phase of therapeutic drug monitoring (TDM). The aim of this study was to compare measured concentrations of 28 psychoactive drugs and 13 metabolites in spiked serum samples stored on standard (plain) tubes vs. barrier gel tubes during a 2-6 days period at room temperature. Read More

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December 2018

Molecular Mechanism of the Cell Membrane Pore Formation Induced by Bubble Stable Cavitation.

J Phys Chem B 2018 Dec 12. Epub 2018 Dec 12.

Microbubbles in combination with ultrasound provides a new and promising way to deliver drugs to living cells. It has been believed that the stable vibration or the collapse of the bubbles under the ultrasound are the two main mechanisms that induce the formation of pores in the cell membrane, through which drugs may get inside the cell cytoplasm. The bubble collapse hypothesis is not only intuitively clear because released shock waves easily penetrate and create pores in the membrane, but also confirmed by both experiment and theory. Read More

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December 2018

Lasing Supraparticles Self-Assembled from Nanocrystals.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

One of the most attractive foreseen commercial applications of semiconductor nanocrystals (NCs) is their use in lasers. Thanks to their high quantum yield, tunable optical properties, photostability and wet-chemical processability, NCs have arisen as promising gain material. Most of these applications, however, rely on incorporation of NCs in lasing cavities separately produced using sophisticated fabrication methods and often difficult to manipulate. Read More

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December 2018

[Close-to-win evaluations are affected by the outcome and delay between stopping the wheels in slot machines].

Psychiatr Hung 2018 ;33(4):340-346

Debreceni Egyetem, Pszichologiai Intezet, Szemelyiseg- es Klinikai Pszichologia Tanszek, Debrecen, Hungary, E-mail:

Introduction: Distinct structural characteristics of gambling may affect the development of gambling addiction differently. The current study is dealing with the frequency of near-miss outcomes which works like secondary reinforcement and thus may contribute to gambling addiction. Authors of this paper argue that different near miss configurations should specifically alter the experiences of the player and this phenomenon can be proved experimentally Methods: Participants played with a computer-simulated slot machine. Read More

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January 2018

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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December 2018

Variation in the prevalence and abundance of acanthocephalans in brown-nosed coatis Nasua nasua and crab-eating foxes Cerdocyon thous in the Brazilian Pantanal.

Braz J Biol 2018 Dec 10. Epub 2018 Dec 10.

Laboratório de Biologia e Parasitologia de Mamíferos Silvestre Reservatórios, Instituto Oswaldo Cruz - IOC, Fundação Oswaldo Cruz - FIOCRUZ, Avenida Brasil, 4365, Manguinhos, CEP 21045-900, Rio de Janeiro, RJ, Brasil.

Host infection by parasites is influenced by an array of factors, including host and environmental features. We investigated the relationship between host sex, body size and age, as well as seasonality on infection patterns by acanthocephalan in coatis (Procyonidae: Nasua nasua) and in crab-eating foxes (Canidae: Cerdocyon thous ) from the Brazilian Pantanal wetlands. Between 2006 and 2009, we collected faecal samples from these hosts and analyzed for the presence of acanthocephalan eggs. Read More

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December 2018

Nursing students' perception about humanized care: an integrative review.

Rev Bras Enferm 2018 ;71(suppl 6):2800-2807

Universidade Federal Fluminense, School of Nursing. Niterói, Rio de Janeiro, Brazil.

Objective: To analyze the productions of knowledge about the students' perception of humanized care.

Method: Study of bibliographical revision of the integrative type. The databases Pubmed, Lilacs, Cuiden and the SciELO virtual library were chosen for selection in October 2017, using the health descriptors "Students, Nursing", "Perception" and "Humanization of assistance", in the languages Portuguese, English and Spanish. Read More

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January 2018

One-pot stapling of interchain disulfides of antibodies using an isobutylene motif.

Org Biomol Chem 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.

Monoclonal antibodies have emerged as an important class of therapeutics in oncological and autoimmune diseases due to their several attractive properties, such as high binding affinity and specificity. However, it has recently become clear that antibodies recovered from serum show a significantly decreased potency owing to various reasons, including deamidation, oxidation, fragment antigen binding (Fab) exchange, and disulfide shuffling. Fab exchange and disulfide shuffling result because of the instability of disulfides in serum. Read More

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December 2018

Network strategy to investigate differential pathways in sporadic amyotrophic lateral sclerosis.

J Cancer Res Ther 2018 Dec;14(Supplement):S1057-S1062

Department of Internal Medicine of TCM, Zhonglu Hospital, Shandong University of TCM, Jinan, Shandong Province, China.

Objective: The objective of this paper was to investigate differential pathways in sporadic amyotrophic lateral sclerosis (SALS) based on pathway network analysis.

Materials And Methods: To achieve this goal, first, differentially expressed genes (DEGs) between SALS and normal controls were identified, and a target network was defined as DEGs correlated interactions from the search tool for the retrieval of interacting genes/proteins (STRING). Second, topological centrality analysis was conducted on the target network to identify hub genes and hub network. Read More

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December 2018

Expression and localization of absent in melanoma 2 in the injured spinal cord.

Neural Regen Res 2019 Mar;14(3):542-552

Clinical Laboratory, the First Affiliated Hospital of Bengbu Medical College; Anhui Key Laboratory of Tissue Transplantation, the First Affiliated Hospital of Bengbu Medical College; Department of Immunology, Bengbu Medical College, and Anhui Key Laboratory of Infection and Immunity at Bengbu Medical College, Bengbu, Anhui Province, China.

In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is similar to that of brain injury, the expression and cellular localization of AIM2 after spinal cord injury is still not very clear. In the present study, we used a rat model of T9 spinal cord contusive injury, produced using the weight drop method. Read More

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March 2019
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Cotranslational Folding of a Pentarepeat β-Helix Protein.

J Mol Biol 2018 Dec 27;430(24):5196-5206. Epub 2018 Oct 27.

Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden; Science for Life Laboratory Stockholm University, Box 1031, SE-171 21 Solna, Sweden. Electronic address:

It is becoming increasingly clear that many proteins start to fold cotranslationally before the entire polypeptide chain has been synthesized on the ribosome. One class of proteins that a priori would seem particularly prone to cotranslational folding is repeat proteins, that is, proteins that are built from an array of nearly identical sequence repeats. However, while the folding of repeat proteins has been studied extensively in vitro with purified proteins, only a handful of studies have addressed the issue of cotranslational folding of repeat proteins. Read More

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December 2018

Cardiac magnetic resonance T1 mapping. Part 1: Aspects of acquisition and evaluation.

Eur J Radiol 2018 Dec 13;109:223-234. Epub 2018 Oct 13.

Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 19/P, 8036 Graz, Austria. Electronic address:

While an enormous number of studies have documented pathological alterations of the myocardial native longitudinal relaxation time (T1) and the fraction of the extracellular myocardial volume (ECV), it has also become clear that continuously evolving T1 mapping sequence, acquisition and evaluation techniques have a substantial impact on quantitative results, making the translation of reported findings into routine clinical use particularly challenging. To provide a basis for the discussion of pathological myocardial T1 and ECV alterations, the present review aims to summarize the methodological aspects of myocardial T1 mapping along with technical and physiological factors influencing results and normal ranges of myocardial native T1 and ECV reported across studies. Read More

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December 2018

Relationship between amikacin blood concentration and ototoxicity in low birth weight infants.

J Infect Chemother 2019 Jan 24;25(1):17-21. Epub 2018 Oct 24.

Department of Pharmacy, Yamanashi Prefectural Central Hospital, Yamanashi, 400-8506, Japan.

Amikacin (AMK) is used as empiric therapy for severe infections such as sepsis in low birth weight (LBW) infants. AMK administered once daily (OD) in adults is reported to be therapeutically effective and prevent side effects, however, evidence on AMK administration in LBW infants is limited, with no clear indications of effectiveness. We performed therapeutic drug monitoring analysis of 20 infants treated with AMK OD for severe infections such as bacteremia. Read More

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January 2019

Status one year after fertility assessment and counselling in women of reproductive age-a qualitative study.

Ups J Med Sci 2018 Dec 12:1-7. Epub 2018 Dec 12.

d Department of Public Health , University of Copenhagen , Copenhagen , Denmark.

Introduction: Over the past 50 years women and men have postponed family formation in high-income societies. Fertility assessment and counselling has been suggested as a method to reduce delayed childbearing and its consequences. This study explored women's perceptions of how attending a fertility assessment intervention influenced their decisions and choices regarding family formation and childbearing. Read More

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December 2018

Sequence effect in the treatment of proliferative diabetic retinopathy with intravitreal ranibizumab and panretinal photocoagulation.

Eur J Ophthalmol 2018 Dec 12:1120672118812270. Epub 2018 Dec 12.

In-Patient Department 2, Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China.

Purpose:: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy.

Methods:: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group). Each subject received three intravitreal ranibizumabs that were interleaved with three panretinal photocoagulations. Read More

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December 2018

Electron transport in nanoporous graphene: Probing the Talbot effect.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

Electrons in graphene can show diffraction and interference phenomena fully analogous to light thanks to their Dirac-like energy dispersion. However it is not clear how this optical analogy persists in nanostructured graphene, e.g. Read More

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December 2018
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A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.

Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.

Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More

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December 2018

Antioxidant enzyme activity in responses to environmentally induced oxidative stress in the 5th instar nymphs of Aiolopus thalassinus (Orthoptera: Acrididae).

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Physiology and Ecotoxicology, University of Silesia in Katowice, Katowice, Poland.

The response of antioxidant enzymes to oxidative environmental stress was determined in 5th instar nymphs of Aiolopus thalassinus (Orthoptera: Acrididae) collected from sites with different level of pollution with heavy metals, PO, and SO. The high polluted site induced higher DNA damage to individuals compared to the control site. The highest values of tail length (TL), tail moment (TM), and percent of DNA in tail (TDNA) were found in the gut of 5th instar nymphs from a high polluted site. Read More

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December 2018

Abnormal Iodine Nutrition-Induced ER Stress Upregulates MCP-1 Expression Through P38/MAPK Signaling Pathway in Thyroid Cells.

Biol Trace Elem Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, NO.34 North Zhongshan Road, Quanzhou City, Fujian Province, People's Republic of China.

Iodine is an important chemical for thyroid hormone synthesis. The association between iodine nutrition status and the risk of disease present U-shaped curve, as either low or high iodine nutrition status will increase the risk of thyroid diseases. Endoplasmic reticulum stress (ER stress), which can induce over expressions of inflammation factors, like monocyte chemo-attractant protein-1 (MCP-1), is related to the pathogenesis of thyroid disease. Read More

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December 2018

What is a cognitive map? Unravelling its mystery using robots.

Cogn Process 2018 Dec 11. Epub 2018 Dec 11.

Centre for Artificial Intelligence Research, Auckland University of Technology, Auckland, New Zealand.

Despite years of research into cognitive mapping, the process remains controversial and little understood. A computational theory of cognitive mapping is needed, but developing it is difficult due to the lack of a clear interpretation of the empirical findings. For example, without knowing what a cognitive map is or how landmarks are defined, how does one develop a computational theory for it? We thus face the conundrum of trying to develop a theory without knowing what is computed. Read More

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December 2018

Sagittal craniosynostosis associated with midline cephalhematoma or vice versa, case report and a review of the literature.

Childs Nerv Syst 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic.

Introduction: Sagittal craniosynostosis associated with midline cephalhematoma is a rare finding. Despite the controversy regarding its etiopathogenesis, this condition represents a clear indication for surgery.

Case Report: We present a case of a 10-week-old boy with an ossified midline vertex cephalhematoma and sagittal craniosynostosis. Read More

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December 2018
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Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

Glycerol inhibition of melanin biosynthesis in the environmental Aeromonas salmonicida 34mel.

Appl Microbiol Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

The environmental strain Aeromonas salmonicida subsp. pectinolytica 34mel produces abundant melanin through the homogentisate pathway in several culture media, but unexpectedly not when grown in a medium containing glycerol. Using this observation as a starting point, this study investigated the underlying causes of the inhibition of melanin synthesis by glycerol, to shed light on factors that affect melanin production in this microorganism. Read More

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December 2018
2 Reads

IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response.

J Immunol Res 2018 13;2018:1827901. Epub 2018 Nov 13.

Life Science School, Liaoning University, Shenyang 110036, China.

Background: Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis. Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis. So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice. Read More

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November 2018

Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles.

Biomed Res Int 2018 13;2018:3591086. Epub 2018 Nov 13.

Faculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstrated that the endocannabinoid system (ECS) plays a central role in male reproductive biology, particularly in the testicular compartment, to date no data point to a role for ECS in the etiopathogenesis of varicocele. Therefore, the present research has been designed to investigate the relationship between testicular ECS gene expression and fertility, using a validated animal model of experimental varicocele (VAR), taking advantage of traditional statistical approaches and artificial neural network (ANN). Read More

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November 2018
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Helping Parents Understand Applied Behavior Analysis: Creating a Parent Guide in 10 Steps.

Behav Anal Pract 2018 Dec 24;11(4):496-503. Epub 2018 Sep 24.

2Department of Educational Studies, The Ohio State University, A356 PAES Bldg, 305 Annie & John Glenn Ave, Columbus, OH 43210 USA.

Interventions based on applied behavior analysis (ABA) have been shown to be effective for children with a wide range of cognitive, adaptive, and functional abilities. Many special education teachers understand the principles of ABA and are adept at implementing ABA interventions for students. However, as the principles of ABA can be complex, communicating with parents about ABA interventions can be challenging. Read More

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December 2018

Factors Affecting the Outcome of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment.

J Ophthalmol 2018 13;2018:9016302. Epub 2018 Nov 13.

MD Ophthalmology Resident, Bharatpur Eye Hospital, Bharatpur-10, 44207 Chitwan, Nepal.

Introduction: Scleral buckle surgery retains a special place in treatment of retinal detachment despite development of new and advanced vitreoretinal surgical techniques. The outcome of any retinal detachment surgery depends on correct selection of patient, type and nature of detachment, and the expertise. This study aims to evaluate various other parameters that determine the outcome of scleral buckle surgery. Read More

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November 2018

Variations in Soil Bacterial Community Diversity and Structures Among Different Revegetation Types in the Baishilazi Nature Reserve.

Front Microbiol 2018 27;9:2874. Epub 2018 Nov 27.

College of Land and Environment, Shenyang Agriculture University, Shenyang, China.

We compared patterns of soil bacterial community diversity and structure in six secondary forests (JM, ; QM, ; MB, mixed Broadleaf forest; BE, ; CB, conifer-broadleaf forest; PT, ) and two plantation forests (LG, Larix gmelinii; PK, ) of the Baishilazi Nature Reserve, China, based on the 16S rRNA high-throughput Illumina sequencing data. The correlations between the bacterial community and soil environmental factors were also examined. The results showed that the broadleaf forests (JM, QM, MB) had higher levels of total C (TC), total N (TN), available N (AN), and available K (AK) compared to the coniferous forests (PT, LG, PK) and conifer-broadleaf forest (CB). Read More

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November 2018

The Functions of Prospection - Variations in Health and Disease.

Front Psychol 2018 27;9:2328. Epub 2018 Nov 27.

The University of Sydney, Brain and Mind Centre, School of Psychology, Sydney, NSW, Australia.

Much of human life revolves around anticipating and planning for the future. It has become increasingly clear that this capacity for is a core adaptive function of the mind. Here, we review the role of prospection in two key functional domains: goal-directed behavior and flexible decision-making. Read More

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November 2018

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic.

Front Pharmacol 2018 27;9:1381. Epub 2018 Nov 27.

Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by mutations in the CF Transmembrane-Conductance Regulator () gene. Unrelenting airway disease begins in infancy and produces a steady deterioration in quality of life, ultimately leading to premature death. While life expectancy has improved, current treatments for CF are neither preventive nor curative. Read More

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November 2018

Altered epidermal fatty acid-binding protein expression in hepatocellular carcinoma predicts unfavorable outcomes.

Cancer Manag Res 2018 23;10:6275-6284. Epub 2018 Nov 23.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China,

Objective: Hepatocellular carcinoma (HCC) is a rapidly proliferating malignancy that requires large amounts of fatty acids to synthesize cellular membranes and provide energy. Epidermal fatty acid-binding protein (EFABP) is uniquely expressed in epidermal cells, but its role and expression in HCC are not clear.

Subjects And Methods: A total of 804 HCC specimens were collected to construct a tissue microarray (TMA) and for immunohistochemistry (IHC) analysis. Read More

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November 2018

Notch signaling promotes serrated neoplasia pathway in colorectal cancer through epigenetic modification of EPHB2 and EPHB4.

Cancer Manag Res 2018 22;10:6129-6141. Epub 2018 Nov 22.

Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, China,

Background: Dysregulation of erythropoietin-producing hepatoma (Eph) proteins in human cancers is extensively documented but not clear in colorectal cancer (CRC). In this study, we aimed to investigate the role of Notch signaling pathway and epigenetic modification of EPHB2 and EPHB4 expression in serrated neoplasia development.

Methods: The expression of EPHB2 and EPHB4 in CRC clinical specimens and cell lines were determined by immunohistochemistry, Western blot, and real-time PCR. Read More

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November 2018

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients' survival.

Cancer Manag Res 2018 20;10:5951-5964. Epub 2018 Nov 20.

Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China,

Background And Aim: Tripartite motif containing (TRIM) family protein has been involved in multiple pathogenesis of cancers. TRIM2 is a member of the family, and its role in clear cell renal cell carcinoma (ccRCC) remains to be unclarifid. Here, we showed the clinical value and biological role of TRIM2 in ccRCC. Read More

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November 2018

Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis.

Onco Targets Ther 2018 21;11:8251-8263. Epub 2018 Nov 21.

School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China,

Background: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. Read More

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November 2018

Childhood-onset growth hormone deficiency and the transition to adulthood: current perspective.

Ther Clin Risk Manag 2018 23;14:2283-2291. Epub 2018 Nov 23.

Development Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK,

Childhood-onset growth hormone deficiency (CO-GHD) is an endocrine condition associated with a broad range of health issues from childhood through to adulthood, which requires particular attention during the transition period from adolescence to young adulthood. There is uncertainty in the clinical practice of the management of CO-GHD during transition regarding the clinical assessment and management of individual patients during and after transition to obtain optimal follow-up and improved health outcomes. Despite the availability of clinical guidelines providing the framework for transition of young adults with CO-GHD, there remains substantial variation in approaching transitional care among pediatric and adult services. Read More

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November 2018

Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts.

Int J Nanomedicine 2018 19;13:7647-7656. Epub 2018 Nov 19.

Department of Micro- and Nanotechnology, DTU Nanotech, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark,

Background: Active, ligand-mediated, targeting of functionalized liposomes to folate receptors (FRs) overexpressed on cancer cells could potentially improve drug delivery and specificity. Studies on folate-targeting liposomes (FTLs) have, however, yielded varying results and generally fail to display a clear benefit of FR targeting.

Method: Tumor accumulating potential of FTLs and NTLs were investigated in a FR overex-pressing xenograft model by positron emission tomography/computed tomography imaging. Read More

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November 2018

Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India.

Indian J Surg Oncol 2018 Dec 22;9(4):558-564. Epub 2018 Sep 22.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh India.

To study the current trends of renal cell carcinoma (RCC) in terms of demographic characteristics, clinical presentation, staging, mode of management, histopathology, and survival characteristics from a high volume tertiary care teaching institute in North India. We retrospectively reviewed the records of all patients of RCC between January 2006 and December 2015 and variables like age, gender, symptoms, tumor size/location/number, stage, type of surgery, histopathology, and survival characteristics were studied. One hundred forty-four patients were included in the study. Read More

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December 2018

Margin Status and Duration of Surgery in Resection of Tongue Carcinoma with Ultrasound Coagulation Device: a Comparative Study.

Indian J Surg Oncol 2018 Dec 20;9(4):501-504. Epub 2018 Jul 20.

Department of Otolaryngology and Head Neck Surgery, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India.

Tongue is one of the most common subsites involved by oral cancer. Improved surgical care and adjuvant therapy, along with better rehabilitation has significantly improved long-term survival and quality of life in patients with oral cancer. Primary surgical treatment is the preferred modality of treatment in cancers of the oral tongue. Read More

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December 2018

Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathological Characteristics and Long-Term Outcome: a Single-Center Experience.

Indian J Surg Oncol 2018 Dec 18;9(4):483-487. Epub 2018 May 18.

Department of Radiology, GIPMER, New Delhi, India.

Solid pseudopapillary neoplasm is a rare tumor of the pancreas. These tumors are considered to have low malignant potential with good prognosis. Due to its rarity, details about clinical presentation and management of the disease are not very clear. Read More

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December 2018

Transanal Total Mesorectal Excision for Treatment of Carcinoma in the Middle or Lower Third Rectum: the Technical Feasibility of the Procedure, Pathological Results, and Clinical Outcome.

Indian J Surg Oncol 2018 Dec 4;9(4):442-451. Epub 2018 Aug 4.

3Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

We are trying to illustrate operative, short-term, and pathological outcomes of transanal total mesorectal excision (TaTME) as a surgical procedure for patients who are suffering cancer in the lower or middle rectum. This study included 25 consecutive patients who underwent TaTME for the mid and low cancer rectum. The primary outcome measures included frequency of postoperative (PO) bleeding, leakage, ileus, days to regain bowel function, days for Foley's removal, and erectile function. Read More

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December 2018

Mammal collections of the Western Hemisphere: a survey and directory of collections.

J Mammal 2018 Dec;99(6):1307-1322

Department of Biology, Angelo State University, San Angelo, TX, USA.

As a periodic assessment of the mammal collection resource, the Systematic Collections Committee (SCC) of the American Society of Mammalogists undertakes decadal surveys of the collections held in the Western Hemisphere. The SCC surveyed 429 collections and compiled a directory of 395 active collections containing 5,275,155 catalogued specimens. Over the past decade, 43 collections have been lost or transferred and 38 new or unsurveyed collections were added. Read More

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December 2018

Preferential attentional engagement drives attentional bias to snakes in Japanese macaques (Macaca fuscata) and humans (Homo sapiens).

Sci Rep 2018 Dec 11;8(1):17773. Epub 2018 Dec 11.

School of Psychology, Curtin University, Perth, Western Australia, Australia.

In humans, attentional biases have been shown to negative (dangerous animals, physical threat) and positive (high caloric food, alcohol) stimuli. However, it is not clear whether these attentional biases reflect on stimulus driven, bottom up, or goal driven, top down, attentional processes. Here we show that, like humans, Japanese macaques show an attentional bias to snakes in a dot probe task (Experiment 1). Read More

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December 2018