48,155 results match your criteria Clear Cell Renal Cell Carcinoma


loss sensitizes cells to PI3Kβ and AKT inhibition.

Oncotarget 2019 Jan 18;10(6):647-659. Epub 2019 Jan 18.

Vanderbilt-Ingram Cancer Center, Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville 37232, TN, USA.

Upregulation of the PI3K pathway has been implicated in the initiation and progression of several types of cancer, including renal cell carcinoma (RCC). Although several targeted therapies have been developed for RCC, durable and complete responses are exceptional. Thus, advanced RCC remains a lethal disease, underscoring the need of robust biomarker-based strategies to treat RCC. Read More

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http://dx.doi.org/10.18632/oncotarget.26567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363018PMC
January 2019

Synchronous bilateral renal cell carcinomas in "Asynchrony of metabolism".

World J Nucl Med 2019 Jan-Mar;18(1):63-65

Department of Nuclear Medicine and PET/CT, Basavatarakam Indo-American Cancer Hospital, Hyderabad, Telangana, India.

Here, we present a case of bilateral synchronous renal cell carcinoma in a 52-year-old male patient, who underwent fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) scan followed by surgical removal of both tumors. On PET scan, left renal mass showed intense FDG uptake while uptake in the right renal mass was minimal. Histopathologically, both tumors were conventional clear cell carcinoma (Fuhrman Grade III). Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357702PMC
February 2019

The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature.

Onco Targets Ther 2019 30;12:953-958. Epub 2019 Jan 30.

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China,

A combination of a Wilms' tumor (WT) and renal cell carcinoma (RCC) is an extremely rare pediatric renal neoplasm. Its prognosis and clinicopathological features remain unclarified. Herein, we describe a case of the coexistence of a WT and an RCC in a male child aged 5 years and 10 months. Read More

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http://dx.doi.org/10.2147/OTT.S186102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361228PMC
January 2019

Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener's granulomatosis: how much radiation dose is needed?

Onco Targets Ther 2019 23;12:753-757. Epub 2019 Jan 23.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, Italy,

Wegener's granulomatosis (WG) is an autoimmune disorder characterized by necrotizing granulomas involving mainly the upper-lower respiratory and renal tracts, albeit a potentially life-threatening involvement of other body parts is not rare. Furthermore, there are several reports accounting for an increased risk of solid malignancies due to the autoimmune disease per se, or the immunosuppressive therapies. Among treatments, radiotherapy could be a therapeutic option as proven by its use in typical WG lesions such as solitary granulomas or subglottic stenosis, successfully treated with low radiation dose. Read More

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http://dx.doi.org/10.2147/OTT.S182011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352862PMC
January 2019

Low Expression of ATM Indicates a Poor Prognosis in Clear Cell Renal Cell Carcinoma.

Clin Genitourin Cancer 2019 Jan 10. Epub 2019 Jan 10.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan Province, PR China. Electronic address:

Introduction: The study was carried out to examine the expression of ataxia telangiectasia mutant (ATM) of clear cell renal cell carcinoma (ccRCC), and to explore the relationship between the expression of ATM and the clinicopathologic parameters and prognosis of ccRCC.

Materials And Methods: Clinicopathologic data of the patients with ccRCC were collected from January 2011 to August 2015 in Xiangya Hospital, Central South University. The immunohistochemical method was used to detect the expression of ATM in ccRCC and adjacent tissues. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.01.003DOI Listing
January 2019

TOX3 Inhibits Cancer Cell Migration and Invasion via Transcriptional Regulation of SNAI1 and SNAI2 in Clear Cell Renal Cell Carcinoma.

Cancer Lett 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, PR China. Electronic address:

Studies on the mechanism of clear cell renal cell carcinoma (ccRCC) progression are lacking. In this study, TOX3 was identified as a novel cancer suppressor gene in ccRCC. Hypermethylation of CpG probes in the promoter region was associated with the functional loss of TOX3 in ccRCC cancer tissues. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.020DOI Listing
February 2019

Essential Research Priorities in Renal Cancer: A Modified Delphi Consensus Statement.

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

Background: Identification of clear and focused research priorities is crucial to drive research forward.

Objective: To identify research priorities in renal cell carcinoma (RCC) through a multidisciplinary collaboration between clinicians, researchers, and patients.

Design, Setting, And Participants: In phase I, 44 RCC experts provided 24 literature reviews within their field, summarising research gaps (RGs). Read More

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http://dx.doi.org/10.1016/j.euf.2019.01.014DOI Listing
February 2019

Impact of Disagreement Between Two Risk Group Models on Prognosis in Patients With Metastatic Renal-Cell Carcinoma.

Clin Genitourin Cancer 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Purpose: To investigate the impact of the risk group disagreement between the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) models on prognosis.

Patients And Methods: We retrospectively evaluated 176 patients with metastatic renal-cell carcinoma who were treated with tyrosine kinase inhibitors as first-line therapy in 5 hospitals between October 2008 and August 2018. The risk group classification differences between the MSKCC and the IMDC models were evaluated using criteria of agreement (identical risk group in both the MSKCC and IMDC models) and disagreement (not identical risk group in both the MSKCC and IMDC models). Read More

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http://dx.doi.org/10.1016/j.clgc.2019.01.006DOI Listing
January 2019

ERK Inhibitor Enhances Everolimus Efficacy through the Attenuation of dNTP Pools in Renal Cell Carcinoma.

Mol Ther Nucleic Acids 2019 Jan 10;14:550-561. Epub 2019 Jan 10.

Department of Urology and Andrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. Electronic address:

The clinical efficiency of everolimus, an mammalian target of rapamycin (mTOR) inhibitor, is palliative as sequential or second-line therapy for renal cell carcinoma (RCC). However, the limited response of everolimus in RCC remains uncertain. In the present study, everolimus-resistant RCC models were established to understand the mechanisms and to seek combination approaches. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.001DOI Listing
January 2019

Association Between Activation of the Programmed Cell Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) Pathway and Pain in Patients with Cancer.

Med Sci Monit 2019 Feb 16;25:1275-1282. Epub 2019 Feb 16.

Department of Palliative Care, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. Read More

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http://dx.doi.org/10.12659/MSM.912632DOI Listing
February 2019

Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer.

Cell Death Dis 2019 Feb 15;10(3):154. Epub 2019 Feb 15.

Department of Urology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, 200003, Shanghai, China.

Long noncoding RNAs (lncRNAs) are implicated in renal cell carcinoma (RCC), but remain largely unclear. Using publicly available transcriptome sequencing data from renal cancer (n = 703) and integrating bioinformatics analyses, we screened and identified a valuable lncRNA, EGFR-AS1. In our validation cohort (n = 204), EGFR-AS1 was significantly upregulated in RCC tissues (P < 0. Read More

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http://www.nature.com/articles/s41419-019-1331-9
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http://dx.doi.org/10.1038/s41419-019-1331-9DOI Listing
February 2019
1 Read
5.014 Impact Factor

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.

Cell Death Dis 2019 Feb 15;10(3):159. Epub 2019 Feb 15.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LXRs) and the NLRP3 inflammasome have been the research hotspots in recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments and biological function experiments to study the roles of LXRα and the NLRP3 inflammasome in RCC. Read More

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http://dx.doi.org/10.1038/s41419-019-1345-3DOI Listing
February 2019

Unexpected Prolonged Survival After Extended and Emergent Resection of Pancreatic Metastases from Renal Cell Carcinoma.

J Gastrointest Cancer 2019 Feb 15. Epub 2019 Feb 15.

Policlinico Umberto I, University "La Sapienza", Rome, Italy.

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http://link.springer.com/10.1007/s12029-019-00209-w
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http://dx.doi.org/10.1007/s12029-019-00209-wDOI Listing
February 2019
1 Read

[Ⅳ. Current Economic Issues in Treatment for Metastatic Renal Cell Carcinoma].

Gan To Kagaku Ryoho 2019 Jan;46(1):50-53

Dept. of Urology, Keio University, School of Medicine.

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January 2019

[Ⅲ. HowWill the Appearance of New Immunotherapeutic Drugs Change the Treatment against Metastatic Renal Cell Carcinoma ?]

Authors:
Nobuo Shinohara

Gan To Kagaku Ryoho 2019 Jan;46(1):45-49

Dept. of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.

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January 2019

[Ⅱ. How Has the Treatment Outcomes for Advanced Renal Cell Carcinoma Improved in the 10 Years after Approval of Targeted Therapy ?]

Gan To Kagaku Ryoho 2019 Jan;46(1):40-44

Dept. of Urology, Graduate School of Medical Sciences, Kyushu University.

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January 2019

[Ⅰ. Are There Any Changes in the Epidemiological Trends in Renal Cell Carcinoma in Japan ?]

Authors:
Hideaki Miyake

Gan To Kagaku Ryoho 2019 Jan;46(1):36-39

Dept. of Urology, Hamamatsu University School of Medicine.

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January 2019

Detection of circulating tumour cells and their potential use as a biomarker for advanced renal cell carcinoma.

Can Urol Assoc J 2019 Jan 21. Epub 2019 Jan 21.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Introduction: The aim of this study was to detect circulating tumour cells (CTCs) in patients with advanced renal cell carcinoma (RCC) using a novel CTC detection platform. Furthermore, we evaluated the clinical outcomes associated with a CTC-positive status.

Methods: A total of 34 patients with advanced RCC (stage III or IV) were prospectively enrolled, and 104 peripheral blood samples were analyzed for the presence of CTCs at various time points. Read More

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http://dx.doi.org/10.5489/cuaj.5605DOI Listing
January 2019
1 Read

Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome-Associated Renal Cell Carcinoma Showing High FDG Uptake.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal-dominant disease, characterized by the development of cutaneous and uterine leiomyomas and renal cell carcinoma (RCC). Approximately 20% to 30% of patients with HLRCC syndrome develop RCC resembling sporadic type 2 papillary RCC, which is aggressive and associated with a poor prognosis. Information on the clinical usefulness of FDG PET/CT in HLRCC syndrome-associated RCC is limited. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002495DOI Listing
February 2019

18F-FDG PET/CT Demonstrates Renal Cell Cancer in a Transplant With Synchronous Intestinal Infection.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Nuclear Medicine and PET/CT, and.

We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002482DOI Listing
February 2019

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report.

Medicine (Baltimore) 2019 Feb;98(7):e14533

Department of Pathology.

Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors.

Patient Concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. Read More

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http://dx.doi.org/10.1097/MD.0000000000014533DOI Listing
February 2019

The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014436DOI Listing
February 2019

Volume Computed Tomography Perfusion Imaging: Evaluation of the Significance in Oncologic Follow-up of Metastasizing Renal Cell Carcinoma in the Early Period of Targeted Therapy - Preliminary Results.

J Comput Assist Tomogr 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiology, and.

Introduction: The aim of this study was to assess the significance of volume computed tomography perfusion imaging of metastasizing renal cell carcinoma (mRCC) in the early period after the initiation of targeted therapy.

Methods: Blood flow (BF), blood volume, and clearance (CL) were calculated in 10 patients with histologically verified mRCC before and 1 month after initiation of targeted therapy using compartmental analysis algorithms. In addition, the longest diameter of tumor was measured for both time points and compared. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000848DOI Listing
February 2019

[Nephron-sparing surgery for renal tumors].

Urologiia 2018 Oct(4):142-146

Republican Hospital , Yakutsk, Russia.

This review article presents the data on the epidemiology of renal cell carcinoma and describes minimally invasive surgery for this disease. The authors discuss the use of warm and cold ischemia, vascular microdissection, and artery embolization in renal tumor surgery, and analyze treatment outcomes. Read More

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October 2018

The diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: Report of the UK experience in the SIOP UK WT 2001 trial.

Pediatr Blood Cancer 2019 Feb 13:e27627. Epub 2019 Feb 13.

Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.

Introduction: The International Society of Paediatric Oncology (SIOP) protocols recommend preoperative chemotherapy appropriate for Wilms tumors (WTs) in children with renal tumors aged ≥6 months, reserving biopsy for "atypical" cases. The Children's Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation.

Method: Retrospective study of concordance between locally reported renal tumor biopsies and central pathology review nephrectomy diagnoses of children enrolled by CCLG centers in the SIOP-WT-2001 study. Read More

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http://dx.doi.org/10.1002/pbc.27627DOI Listing
February 2019
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Pre-cryoablation Embolization of Renal Tumors: Decreasing Probes and Saving Loads.

Cureus 2018 Dec 3;10(12):e3676. Epub 2018 Dec 3.

Radiology, University of Florida College of Medicine, Jacksonville, USA.

The use of adjuvant pre-ablation embolization for renal tumors has been reported in endophytic, centrally located lesions to reduce the risk of injuring the renal collecting system during subsequent cryoablation. In this technical report, we present another utilization of adjuvant pre-ablation embolization, applied for the purpose of decreasing the number of cryoablation probes needed in the ablation intervention. This novel procedural protocol not only decreases the cost of the procedure, but also preserves more normal renal parenchyma, and decreases the risk of injuries related to probe positioning. Read More

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http://dx.doi.org/10.7759/cureus.3676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367110PMC
December 2018

Renal Cell Carcinoma Metastases to the Pancreas and the Thyroid Gland: A Case Report and Review of the Literature.

Cureus 2018 Dec 1;10(12):e3667. Epub 2018 Dec 1.

Surgery, University of North Texas Health Science Center, Fort Worth, USA.

Renal cell carcinoma (RCC) is known for having unpredictable clinical behavior. Metastases can occur in unusual locations with a long-time lag after the treatment of the primary cancer. Despite being a sign of poor prognosis, aggressive metastasectomy may prolong survival. Read More

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http://dx.doi.org/10.7759/cureus.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364949PMC
December 2018

Accumulation of fructose 1,6-bisphosphate protects clear cell renal cell carcinoma from oxidative stress.

Lab Invest 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.

Clear cell renal cell carcinoma (ccRCC) is characterized by the activation of hypoxia-inducible factors and enhanced aerobic glycolysis. In our previous study, metabolic profiling revealed a threefold increase of fructose 1,6-bisphosphate (FBP) in ccRCC tissue compared with normal kidney tissue. As an important intermediate metabolite, its role in cancer development remains unknown. Read More

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http://dx.doi.org/10.1038/s41374-019-0203-3DOI Listing
February 2019

Clear cell renal cell carcinoma bone metastasis: What should be considered in prognostic evaluation.

Eur J Surg Oncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Urology, Peking University People's Hospital, Beijing, 100044, China. Electronic address:

Introduction: Knowledge of clear cell renal cell carcinoma bone metastasis (ccRCC-BM) remains scarce. This study depicts clinical, pathological and outcome features of the disease and provides suggestions to establish prognosis prediction system more appropriate for ccRCC-BM.

Materials And Methods: Patients with ccRCC-BM had clinical, pathological data collected. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.221DOI Listing
February 2019

Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus.

BMC Cancer 2019 Feb 13;19(1):144. Epub 2019 Feb 13.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Panjiayuan Nanli 17#, Chaoyang District, 100021, People's Republic of China.

Background: Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few studies have focused on postoperative long-term survival of RCC patients exclusively with RVTT. Our aim was to investigate the independent prognostic factors for locally advanced RCC with RVTT in China. Read More

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http://dx.doi.org/10.1186/s12885-019-5359-0DOI Listing
February 2019

Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

World J Urol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., J8.130, Dallas, TX, 75390-9110, USA.

Purpose: To evaluate the prognostic value of BRCA1-associated protein-1 (BAP1) expression in upper tract urothelial carcinoma (UTUC), as BAP1 mutations have been associated with prognostic implications in urologic and non-urologic malignancies.

Methods: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy (RNU) for high-grade UTUC from 1990-2008. Immunohistochemistry (IHC) for BAP1 was performed on tissue microarrays. Read More

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http://link.springer.com/10.1007/s00345-019-02678-x
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http://dx.doi.org/10.1007/s00345-019-02678-xDOI Listing
February 2019
2 Reads

STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target VHL-inactivated cells.

Am J Physiol Cell Physiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9. Atlantic Cancer Research Institute, Moncton, E1C 8X3, Canada.

Autophagy is a highly conserved, homeostatic process by which cytosolic components reach lysosomes for degradation. The roles that play different autophagic processes in cancer are complex and remain cancer-type and -stage dependent. Renal cell carcinoma (RCC) is the most common subtype of kidney cancer and is characterized by the inactivation of the VHL tumor suppressor. Read More

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http://dx.doi.org/10.1152/ajpcell.00483.2018DOI Listing
February 2019

Adjuvant therapy in renal cell carcinoma: the perspective of urologists.

Int J Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Ludwig Maximilian University, Marchioninistr. 15, 81377, Munich, Germany.

Background: Until recently, there was no approved adjuvant therapy (AT) for renal cell carcinoma (RCC) unless sunitinib was approved in the US. We evaluated clinical opinion and estimated use regarding different treatment options and patient selection of AT in RCC patients based on current scientific data and individual experience in Germany.

Methods: We conducted an anonymous survey during a national urology conference in 01/2017. Read More

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http://dx.doi.org/10.1007/s10147-019-01398-xDOI Listing
February 2019

Preoperative controlling nutritional status (CONUT) score as a novel immune-nutritional predictor of survival in non-metastatic clear cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.

J Cancer Res Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Purpose: This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.

Methods: We retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005-2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up < 12 months. We defined high and low CONUT according to cut-off of (2). Read More

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http://dx.doi.org/10.1007/s00432-019-02846-xDOI Listing
February 2019
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Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma.

Cancer Immunol Immunother 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Purpose: Hypoxia-inducible factor 2α (HIF-2α) overexpression leads to activation of angiogenic pathways. However, little is known about the association between HIF-2α expression and anti-tumor immunity in clear cell renal cell carcinoma (ccRCC). We aimed to explore how HIF-2α influenced the microenvironment and the underlying mechanisms. Read More

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http://dx.doi.org/10.1007/s00262-019-02314-yDOI Listing
February 2019

Economic evaluation of sunitinib versus pazopanib and best supportive care for the treatment of metastatic renal cell carcinoma in Chile: cost-effectiveness analysis and a mixed treatment comparison.

Expert Rev Pharmacoecon Outcomes Res 2019 Feb 13. Epub 2019 Feb 13.

a Health Technology Assessment Unit, Center of Clinical Research, Faculty of Medicine , Pontificia Universidad Católica de Chile.

Backgroud: Sunitinib and Pazopanib are two metastatic renal cell carcinoma (MRCC) treatment alternatives, however the health system in Chile does not consider coverage for any. The cost-effectiveness versus relevant comparator was assessed to support evidence-based decision making.

Methods: A four health states Markov model was built: first, second line treatments, BSC and death. Read More

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http://dx.doi.org/10.1080/14737167.2019.1580572DOI Listing
February 2019

Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.

PeerJ 2019 6;7:e6396. Epub 2019 Feb 6.

Urology, Tongji Hospital,Tongji Medical College, Huazhong University of Science Technology, Wuhan, Hubei, China.

Background: Histone lysine methyltransferases (HMTs), a category of enzymes, play essential roles in regulating transcription, cellular differentiation, and chromatin construction. The genomic landscape and clinical significance of HMTs in renal cell carcinoma (RCC) remain uncovered.

Methods: We conducted an integrative analysis of 50 HMTs in RCC and discovered the internal relations among copy number alterations (CNAs), expressive abundance, mutations, and clinical outcome. Read More

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http://dx.doi.org/10.7717/peerj.6396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368835PMC
February 2019

Accuracy of renal tumour biopsy for the diagnosis and subtyping of papillary renal cell carcinoma: analysis of paired biopsy and nephrectomy specimens with focus on discordant cases.

J Clin Pathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

Aims: Renal tumour biopsy (RTB) is increasingly recognised as a useful diagnostic tool in the management of small renal masses, particularly those that are incidentally found. Intratumoural heterogeneity with respect to morphology, grade and molecular features represents a frequently identified limitation to the use of RTB. While previous studies have evaluated pathological correlation between RTB and nephrectomy, no studies to date have focused specifically on the role of RTB for the diagnosis of papillary renal cell carcinoma (PRCC) and its further subclassification into clinically relevant subtypes. Read More

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2018-205655
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http://dx.doi.org/10.1136/jclinpath-2018-205655DOI Listing
February 2019
2 Reads

A simple three-dimensional hydrogel platform enables ex vivo cell culture of patient and PDX tumors for assaying their response to clinically relevant therapies.

Mol Cancer Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, Cedars-Sinai Medical Center

A cell culture platform that enables ex vivo tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g. Temozolomide, TMZ) in a clinically relevant timeframe would be very useful in translational research and personalized medicine. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0359DOI Listing
February 2019

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell 2019 Feb;35(2):204-220.e9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Alterations in chromatin remodeling genes have been increasingly implicated in human oncogenesis. Specifically, the biallelic inactivation of the SWI/SNF subunit SMARCB1 results in the emergence of extremely aggressive pediatric malignancies. Here, we developed embryonic mosaic mouse models of malignant rhabdoid tumors (MRTs) that faithfully recapitulate the clinical-pathological features of the human disease. Read More

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http://dx.doi.org/10.1016/j.ccell.2019.01.006DOI Listing
February 2019
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PET imaging in renal cancer.

Curr Opin Oncol 2019 Feb 11. Epub 2019 Feb 11.

Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Denmark.

Purpose Of Review: Worldwide, over 400 000 new cases of kidney cancer were diagnosed and over 175 000 deaths anticipated in 2018. It is ranked as the 14th most common cancer in women and 9th most common in men. Imaging is important for initial detection, staging, and monitoring to assist treatment planning, but conventional anatomic imaging is limited. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000518DOI Listing
February 2019
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Influence of segmentation margin on machine learning-based high-dimensional quantitative CT texture analysis: a reproducibility study on renal clear cell carcinomas.

Eur Radiol 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Objective: To determine the possible influence of segmentation margin on each step (feature reproducibility, selection, and classification) of the machine learning (ML)-based high-dimensional quantitative computed tomography (CT) texture analysis (qCT-TA) of renal clear cell carcinomas (RcCCs).

Materials And Methods: For this retrospective study, 47 patients with RcCC were included from a public database. Two segmentations were obtained by two radiologists for each tumour: (i) contour-focused and (ii) margin shrinkage of 2 mm. Read More

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http://dx.doi.org/10.1007/s00330-019-6003-8DOI Listing
February 2019
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Metastatic tumors in the pancreas: the role of endoscopic ultrasound-guided fine-needle aspiration.

Rev Esp Enferm Dig 2019 Feb 11. Epub 2019 Feb 11.

Aparato Digestivo, Clínica Universidad de Navarra.

Background And Objectives: there are few published data on the use of EUS guided fine-needle aspiration in secondary pancreatic lesions. We describe the largest series published so far in a European country.

Patients And Methods: a retrospective review of the cases identified in our institution from 2004 to 2016 has been recorded. Read More

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http://dx.doi.org/10.17235/reed.2019.5914/2018DOI Listing
February 2019
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FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis.

Int J Biol Sci 2019 24;15(3):647-656. Epub 2019 Jan 24.

Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong Province, China.

F-box only protein 22 (FBXO22), a substrate receptor of the SKP1-Cullin 1-F-box protein (SCF) E3 ubiquitin ligase that targets key regulators of cellular activities for ubiquitylation and degradation, plays important roles in the progression of human cancer. However, little is known about the role of FBXO22 in renal cell carcinoma (RCC). This study aims to explore the biological function of FBXO22 in RCC progression and its specific regulation mechanism. Read More

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http://www.ijbs.com/v15p0647.htm
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http://dx.doi.org/10.7150/ijbs.31293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367582PMC
January 2019
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Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2.

Int J Biol Sci 2019 1;15(3):617-627. Epub 2019 Jan 1.

Department of Ultrasonography, China-Japan Union Hospital, Jilin University, Changchun, China.

Metformin, a common therapeutics for type 2 diabetics, was recently demonstrated to possess antitumor activity in various cancer types. However, its therapy effect in renal cell carcinoma (RCC) still remains controversial. In this study, we found that metformin treatment in RCC cells lead to activation of AMPK, which suppressed the cell proliferation under normal condition, but enhanced cell proliferation under glucose deprivation (GD) condition. Read More

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http://dx.doi.org/10.7150/ijbs.29689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367591PMC
January 2019
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TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway.

Int J Biol Sci 2019 1;15(3):587-597. Epub 2019 Jan 1.

Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China.

Tribbles pseudokinase 3 (TRIB3) is a member of the mammalian pseudokinase tribbles family and is involved in multiple biological processes. However, the role of TRIB3 in renal cell carcinoma (RCC) remains unclear. In this study, we aimed to elucidate the biological functions of TRIB3 in RCC and explore its underlying mechanisms. Read More

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http://www.ijbs.com/v15p0587.htm
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http://dx.doi.org/10.7150/ijbs.29737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367588PMC
January 2019
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Natural history of renal tumours in von Hippel-Lindau disease: a large retrospective study of Chinese patients.

J Med Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

Background: Historically, renal cell carcinoma (RCC) is one of the main causes of death in von Hippel-Lindau (VHL) disease. However, the natural history of VHL-related RCC has not been thoroughly elucidated to date. This report described the natural history of VHL-related RCC in a large Chinese VHL cohort and might be helpful in the surveillance and treatment of VHL disease. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105567DOI Listing
February 2019
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3-weekly or weekly cisplatin concurrently with radiotherapy for patients with squamous cell carcinoma of the head and neck - a multicentre, retrospective analysis.

Radiat Oncol 2019 Feb 11;14(1):32. Epub 2019 Feb 11.

Department Internal Medicine, University Hospital Basel, Medical Oncology, Petersgraben 4, 4031, Basel, Switzerland.

Background: Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-risk features. The standard regimen includes 3-weekly cisplatin, but weekly regimens are often used to lower toxicity. Reaching a cumulative dose of ≥200 mg/m cisplatin was shown being associated with improved outcome. Read More

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http://dx.doi.org/10.1186/s13014-019-1235-yDOI Listing
February 2019
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Oncogenic PITX2 Facilitates Tumor Cell Drug Resistance by Inverse Regulation of hOCT3/SLC22A3 and ABC Drug Transporters in Colon and Kidney Cancers.

Cancer Lett 2019 Feb 8. Epub 2019 Feb 8.

Institute of Physiology, Pathophysiology and Toxicology, Centre of Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Strasse 12, Witten, Germany. Electronic address:

Oncogenic pituitary homeobox 2 (PITX2), a de facto master regulator of developmental organ asymmetry, previously upregulated multidrug resistance (MDR) P-glycoprotein (ABCB1) in A498 renal cell carcinoma (RCC) cells. The role of PITX2 isoforms in MDR cancers was investigated. Data mining correlated elevated PITX2 in >30% of cancers analyzed, maximally in colon (4. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.044DOI Listing
February 2019
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