636 results match your criteria Classification and Complications of Traumatic Brain Injury


Isolated severe blunt traumatic brain injury: effect of obesity on outcomes.

J Neurosurg 2020 Jun 12:1-8. Epub 2020 Jun 12.

2Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, LAC+USC Medical Center, University of Southern California, Los Angeles, California.

Objective: Obesity has been widely reported to confer significant morbidity and mortality in both medical and surgical patients. However, contemporary data indicate that obesity may confer protection after both critical illness and certain types of major surgery. The authors hypothesized that this "obesity paradox" may apply to patients with isolated severe blunt traumatic brain injuries (TBIs). Read More

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http://dx.doi.org/10.3171/2020.3.JNS193458DOI Listing

Chemoprophylaxis and Venous Thromboembolism in Traumatic Brain Injury at Different Trauma Centers.

Am Surg 2020 Apr;86(4):362-368

From the *Department of Trauma, Burns and Surgical Critical Care, University of California, Irvine Medical Center, Orange, California; and.

Patients with severe traumatic brain injury (TBI) are at an increased risk of venous thromboembolism (VTE). Because of concerns of worsening intracranial hemorrhage, clinicians are hesitant to start VTE chemoprophylaxis in this population. We hypothesized that ACS Level I trauma centers would be more aggressive with VTE chemoprophylaxis in adults with severe TBI than Level II centers. Read More

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Thirty- and 90-Day Readmissions After Treatment of Traumatic Subdural Hematoma: National Trend Analysis.

World Neurosurg 2020 Apr 6. Epub 2020 Apr 6.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Radiology & Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address:

Objective: Subdural hematoma (SDH), a form of traumatic brain injury, is a common disease that requires extensive patient management and resource utilization; however, there remains a paucity of national studies examining the likelihood of readmission in this patient population. The aim of this study is to investigate differences in 30- and 90-day readmissions for treatment of traumatic SDH using a nationwide readmission database.

Methods: The Nationwide Readmission Database years 2013-2015 were queried. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.168DOI Listing

Investigation of Machine Learning Approaches for Traumatic Brain Injury Classification via EEG Assessment in Mice.

Sensors (Basel) 2020 Apr 4;20(7). Epub 2020 Apr 4.

Department of Electrical Engineering and Computer Science, University of California, Irvine, CA 92607, USA.

Due to the difficulties and complications in the quantitative assessment of traumatic brain injury (TBI) and its increasing relevance in today's world, robust detection of TBI has become more significant than ever. In this work, we investigate several machine learning approaches to assess their performance in classifying electroencephalogram (EEG) data of TBI in a mouse model. Algorithms such as decision trees (DT), random forest (RF), neural network (NN), support vector machine (SVM), K-nearest neighbors (KNN) and convolutional neural network (CNN) were analyzed based on their performance to classify mild TBI (mTBI) data from those of the control group in wake stages for different epoch lengths. Read More

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http://dx.doi.org/10.3390/s20072027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180997PMC

Traumatic brain injury preceding clinically diagnosed α-synucleinopathies: A case-control study.

Neurology 2020 02 28;94(8):e764-e773. Epub 2020 Jan 28.

From the Alix School of Medicine (S.H.), Department of Health Sciences Research (M.M.M., R.S.), and Department of Neurology (P.T., J.E.A., J.H.B., R.S.), Mayo Clinic, Rochester, MN.

Objective: To determine the association between traumatic brain injury (TBI) and any clinically diagnosed α-synucleinopathy including Parkinson disease (PD), dementia with Lewy bodies (DLB), PD dementia (PDD), and multiple system atrophy (MSA).

Methods: Using the medical records-linkage system of the Rochester Epidemiology Project, we identified incident cases of α-synucleinopathies in Olmsted County, Minnesota, from 1991 to 2010, matching by age (±1 year) at symptom onset and sex to controls. We reviewed records of cases and controls to detect TBI prior to clinical-motor onset of any α-synucleinopathies. Read More

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http://dx.doi.org/10.1212/WNL.0000000000008995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136055PMC
February 2020

Admission Perfusion CT for Classifying Early In-Hospital Mortality of Patients With Severe Traumatic Brain Injury: A Pilot Study.

AJR Am J Roentgenol 2020 04 28;214(4):872-876. Epub 2020 Jan 28.

Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada.

The purposes of this study were to assess the feasibility and safety of perfusion CT of patients with severe traumatic brain injury (TBI) at hospital admission and to examine whether early in-hospital mortality could be characterized with perfusion CT (PCT). The hypothesis was that PCT can be used to characterize brain death, when present, in patients with severe TBI at hospital admission. In this prospective cohort pilot study, PCT was performed on patients with severe TBI at first imaging workup at hospital admission. Read More

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http://dx.doi.org/10.2214/AJR.19.21599DOI Listing

Risk factors associated with the progression of extra-axial hematoma in the original frontotemporoparietal site after contralateral decompressive surgery in traumatic brain injury patients.

Chin J Traumatol 2020 Feb 3;23(1):45-50. Epub 2020 Jan 3.

Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China. Electronic address:

Purpose: To introduced our experience with progressive extra-axial hematoma (EAH) in the original frontotemporoparietal (FTP) site after contralateral decompressive surgery (CDS) in traumatic brain injury patients and discuss the risk factors associated with this dangerous situation.

Methods: This retrospective study was conducted on 941 patients with moderate or severe TBI treated in Daping Hospital, Army Medical University, Chongqing, China in a period over 5 years (2013-2017). Only patients with bilateral lesion, the contralateral side being the dominant lesion, and decompressive surgery on the contralateral side conducted firstly were included. Read More

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http://dx.doi.org/10.1016/j.cjtee.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049639PMC
February 2020

Application of Mismatch Negative in Evaluation of Severity of Mental Disorders due to Traumatic Brain Injury.

Fa Yi Xue Za Zhi 2019 Dec 25;35(6):695-700. Epub 2019 Dec 25.

Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Abstract: Objective To explore the applied value of mismatch negative (MMN) in evaluation of severity of mental disorders due to traumatic brain injury. Methods Thirty-five patients(case group) that conform to the diagnostic criteria of organic (traumatic brain injury) mental disorder in ICD-10 Classification of Mental and Behavioural Disorders criteria were selected. Twenty-four healthy subjects (normal control group) that matched the case group in terms of gender, age composition ratio and educational level were selected. Read More

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http://dx.doi.org/10.12116/j.issn.1004-5619.2019.06.009DOI Listing
December 2019

Predicting outcome in patients with moderate to severe traumatic brain injury using electroencephalography.

Crit Care 2019 Dec 11;23(1):401. Epub 2019 Dec 11.

Clinical Neurophysiology Group, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, the Netherlands.

Background: Better outcome prediction could assist in reliable quantification and classification of traumatic brain injury (TBI) severity to support clinical decision-making. We developed a multifactorial model combining quantitative electroencephalography (qEEG) measurements and clinically relevant parameters as proof of concept for outcome prediction of patients with moderate to severe TBI.

Methods: Continuous EEG measurements were performed during the first 7 days of ICU admission. Read More

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http://dx.doi.org/10.1186/s13054-019-2656-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907281PMC
December 2019

Surgical treatment of traumatic distal anterior cerebral artery aneurysm: a report of nine cases from a single centre.

Acta Neurochir (Wien) 2020 03 4;162(3):523-529. Epub 2019 Dec 4.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, HuBei Province, People's Republic of China.

Background: Traumatic distal anterior cerebral artery (dACA) aneurysm is rare and can be easily neglected and misdiagnosed in patients with trauma. The aim of this study was to explore the radiologic characteristics of and therapeutic strategies for traumatic dACA aneurysm and to improve our understanding of unusual complications after trauma.

Methods: The clinical data of nine cases of traumatic dACA aneurysm from our neurosurgical department from July 1, 2010, to July 1, 2018, were retrospectively analysed. Read More

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http://dx.doi.org/10.1007/s00701-019-04121-xDOI Listing

Risks, costs, and outcomes of cerebrospinal fluid leaks after pediatric skull fractures: a MarketScan analysis between 2007 and 2015.

Neurosurg Focus 2019 11;47(5):E10

Objective: Skull fractures are common after blunt pediatric head trauma. CSF leaks are a rare but serious complication of skull fractures; however, little evidence exists on the risk of developing a CSF leak following skull fracture in the pediatric population. In this epidemiological study, the authors investigated the risk factors of CSF leaks and their impact on pediatric skull fracture outcomes. Read More

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http://dx.doi.org/10.3171/2019.8.FOCUS19543DOI Listing
November 2019

Resective surgery for drug-resistant posttraumatic epilepsy: predictors of seizure outcome.

J Neurosurg 2019 Oct 4:1-8. Epub 2019 Oct 4.

1Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University.

Objective: The object of this study was to evaluate surgical outcomes and prognosis factors in patients with drug-resistant posttraumatic epilepsy (PTE) who had undergone resective surgery.

Methods: The authors retrospectively reviewed the records of all patients with drug-resistant PTE who had undergone resective surgery at Sanbo Brain Hospital, Capital Medical University, in the period from January 2008 to December 2016. All patients had a follow-up period of at least 2 years. Read More

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http://dx.doi.org/10.3171/2019.7.JNS191233DOI Listing
October 2019
1 Read

Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage.

BMC Neurosci 2019 09 18;20(1):49. Epub 2019 Sep 18.

Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany.

Background: In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is the reported use of analgesics. We determined surrogate parameters of pain and general well-being after subarachnoid hemorrhage (SAH), as well as the potential for improvement by different systemic analgesia paradigms. Read More

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http://dx.doi.org/10.1186/s12868-019-0531-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751841PMC
September 2019
1 Read

Investigating the incidence and magnitude of heterotopic ossification with and without joints involvement in patients with a limb fracture and mild traumatic brain injury.

Bone Rep 2019 Dec 13;11:100222. Epub 2019 Aug 13.

Centre de Recherche de l'Hôpital Sacré-Coeur de Montréal, Montréal, Québec, Canada.

Objectives: This study seeks to evaluate the incidence rate of heterotopic ossification (HO) formation in patients afflicted by an isolated limb fracture (ILF) and a concomitant mild traumatic brain injury (mTBI).

Methods: The current study is an observational study including ILF patients with or without a concomitant mTBI recruited from an orthopedic clinic of a Level 1 Trauma Hospital. Patients were diagnosed with a mTBI according to the American Congress of Rehabilitation Medicine (ACRM) criteria. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706636PMC
December 2019
1 Read

Discrepancy Between Internal and External Intracranial Pressure Transducers: Quantification of an Old Source of Error in EVDs?

World Neurosurg 2020 Jan 5;133:e18-e25. Epub 2019 Aug 5.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Intracranial pressure monitoring remains the foundation for prevention of secondary injury after traumatic brain injury and is most commonly performed using an external ventricular drain or intraparenchymal pressure monitor. The Integra Flex ventricular catheter combines an external ventricular catheter with a pressure transducer embedded in the tip of the catheter to allow continuous pressure readings while simultaneously draining cerebrospinal fluid. Discrepancies between measurements from the continuously reported internal pressure transducer and intermittently assessed and externally transduced ventricular drain prompted an analysis and characterization of pressures transduced from the same ventricular source. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.213DOI Listing
January 2020

Sex Differences in In-hospital Complications Among Older Adults After Traumatic Brain Injury.

J Surg Res 2019 11 3;243:427-433. Epub 2019 Jul 3.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Older adults have the highest rates of hospitalization and mortality after traumatic brain injury (TBI) and suffer poorer outcomes compared with younger adults with similar injuries. Non-neurological complications can significantly impact outcomes. Evidence suggests that women may have better outcomes after TBI. Read More

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http://dx.doi.org/10.1016/j.jss.2019.05.053DOI Listing
November 2019
4 Reads

Craniocerebral disproportion after decompressive craniectomy in infants: The hidden enemy of cranial repair?

Childs Nerv Syst 2019 09 27;35(9):1467-1471. Epub 2019 May 27.

Pediatric Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Introduction: Cranioplasty aims at restoring the physiological integrity and volume of the skull. Any disproportion between the intracranial content and the volume of the container may favor the occurrence of complications. A classification of volume mismatches is proposed. Read More

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http://dx.doi.org/10.1007/s00381-019-04166-4DOI Listing
September 2019
5 Reads

The Bell Has Rung: Answering the Door for Student-Athlete Concussion Issues in the National Collegiate Athletic Association.

Authors:
Aaron Caputo

J Law Health 2019 ;32(1):58-88

Cleveland-Marshall College of Law.

This Note examines the NCAA's unwillingness to enforce the requirement that all NCAA institutions must implement a concussion management plan; the NCAA's refusal to apply its appropriate enforcement mechanism when member institutions violate their concussion management plans, which are instituted in order to protect student-athletes from concussions; how both of these failures result in more concussions and a higher probability of debilitating long-term effects; and solutions to remedy this grave injustice. Part II describes what a concussion is, the long-term effects of concussions, the NCAA's management of concussions, and lawsuits challenging the NCAA in relation to concussions. Part III analyzes the inefficiencies of the NCAA in its management of concussions, the previous and current lawsuits' failure to stimulate change within the NCAA, and the proposed solutions that will help create a safe environment for student-athletes. Read More

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December 2019

Health Care Utilization and Mental Health Diagnoses Among Veterans With Tinnitus.

Am J Audiol 2019 Apr;28(1S):181-190

VA Rehabilitation Research & Development Service, National Center for Rehabilitative Auditory Research, VA Portland Health Care System, OR.

Purpose Tinnitus is prevalent among military Veterans and may frequently co-occur with mental health disorders. This study examined health care utilization and mental health diagnoses among Veterans with and without tinnitus who receive Department of Veterans Affairs (VA) health care. Method We randomly sampled 10% of VA health care users for a 5-year period between 2011 and 2016. Read More

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http://pubs.asha.org/doi/10.1044/2018_AJA-TTR17-18-0042
Publisher Site
http://dx.doi.org/10.1044/2018_AJA-TTR17-18-0042DOI Listing
April 2019
19 Reads

Prediction of Early Intracranial Hypertension After Severe Traumatic Brain Injury: A Prospective Study.

World Neurosurg 2019 Jul 19;127:e1242-e1248. Epub 2019 Apr 19.

Department of Anaesthesiology and Critical Care Medicine, Surgical Intensive Care Unit - Trauma Center, Créteil, France.

Objective: This study aimed to assess the reliability of clinical features, noninvasive transcranial Doppler-related pulsatility index (PI) calculation, and optic nerve sheath diameter (ONSD) measured by ultrasound (US) and initial computed tomography (CT) scan (Marshall CT scan classification) in predicting the occurrence of early (<24 hours) high intracranial pressure (EHICP) (>20 mm Hg) after severe traumatic brain injury (TBI).

Methods: We conducted an observational prospective study in a level 1 trauma center. Patients were measured simultaneously for PI and US ONSD in the triage zone. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.121DOI Listing
July 2019
1 Read

Polyarticular Neurogenic Heterotopic Ossification in a Spinal Cord Injury: A Case Report from Saudi Arabia.

Cureus 2019 Feb 5;11(2):e4019. Epub 2019 Feb 5.

Physical Medicine and Rehabilitation, King Fahad Medical City, Riyadh, SAU.

A 33-year-old male victim of a motor vehicle accident, who presented with a T12 (thoracic 12 vertebra) burst fracture (ISNCSCI T11 AIS-A: International Standards for Neurological Classification of Spinal Cord Injury T11 ASIA Impairment Scale), was admitted to a rehabilitation hospital. A stage-II left ischial pressure ulcer was also reported. An X-ray of the pelvis revealed bilateral neurogenic heterotopic ossification (NHO) in both hips and knees, which was further confirmed by TC-99m methylene diphosphonate (MDP) bone scintigraphy. Read More

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http://dx.doi.org/10.7759/cureus.4019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453613PMC
February 2019
10 Reads

Speech-based markers for posttraumatic stress disorder in US veterans.

Depress Anxiety 2019 07 22;36(7):607-616. Epub 2019 Apr 22.

Stanford Research Institute International, Menlo Park, California.

Background: The diagnosis of posttraumatic stress disorder (PTSD) is usually based on clinical interviews or self-report measures. Both approaches are subject to under- and over-reporting of symptoms. An objective test is lacking. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22890
Publisher Site
http://dx.doi.org/10.1002/da.22890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602854PMC
July 2019
28 Reads

Spinal trauma in Tanzania: current management and outcomes.

J Neurosurg Spine 2019 04;31(1):103-111

Departments of1Neurological Surgery and.

Objective: Spinal trauma is a major cause of disability worldwide. The burden is especially severe in low-income countries, where hospital infrastructure is poor, resources are limited, and the volume of cases is high. Currently, there are no reliable data available on incidence, management, and outcomes of spinal trauma in East Africa. Read More

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http://dx.doi.org/10.3171/2018.12.SPINE18635DOI Listing
April 2019
26 Reads

SIAXI: Placebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea.

Neurology 2019 04 27;92(17):e1982-e1991. Epub 2019 Mar 27.

From the Parkinson-Klinik Ortenau (W.H.J.), Wolfach, Germany; Department of Neurology (A.F.), Faculty of Health Science, Medical University of Warsaw, Poland; Department of Otorhinolaryngology (O.M.), University Hospital Brussels, Vrije Universiteit Brussel, Belgium; Neurological Outpatient Clinic for Parkinson's Disease and Deep Brain Stimulation (C.O.), Gera, Germany; Department of Neurological-Psychiatric Nursing (J.S.), Medical University of Gdansk; Neurology Department (J.S.), St. Adalbert Hospital, Gdansk; Department of Extrapyramidal Diseases (A. Bogucki), Medical University of Łódź; Department of Neurology and Stroke Unit (S.O.), Medical University of Silesia, Katowice; Department of Neurology (M.B.), Collegium Medicum, Jagiellonian University, Krakow, Poland; Department of Neurology (F.P.), Georgetown University Hospital, Washington, DC; Merz Pharmaceuticals GmbH (B.F.-B., J.C.), Frankfurt am Main, Germany; Complete Medical Communications (C.J.C.), Glasgow, UK; Department of Otolaryngology/Head and Neck Surgery (A. Blitzer), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (A. Blitzer), Icahn School of Medicine at Mt. Sinai, New York; and NY Center for Voice and Swallowing Disorders (A. Blitzer), New York, NY.

Objective: This pivotal phase III study, SIAXI, investigated the efficacy and safety of incobotulinumtoxinA for the treatment of chronic sialorrhea due to Parkinson disease (PD), atypical parkinsonism, stroke, or traumatic brain injury (TBI).

Methods: Adult patients with PD (70.7%), atypical parkinsonism (8. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511076PMC
April 2019
9 Reads

Predictive Power of Head Impact Intensity Measures for Recognition Memory Performance.

Mil Med 2019 03;184(Suppl 1):206-217

Walter Reed Army Institute of Research, Center for Military Psychiatry and Neuroscience, 503 Robert Grant Ave, Silver Spring, MD.

Subconcussive head injuries are connected to both short-term cognitive changes and long-term neurodegeneration. Further study is required to understand what types of subconcussive impacts might prove detrimental to cognition. We studied cadets at the US Air Force Academy engaged in boxing and physical development, measuring head impact motions during exercise with accelerometers. Read More

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http://dx.doi.org/10.1093/milmed/usy415DOI Listing
March 2019
7 Reads

Relationships and Evidence-Based Theoretical Perspectives on Persisting Symptoms and Functional Impairment Among Mild Traumatic Brain Injury and Behavioral Health Conditions.

Mil Med 2019 03;184(Suppl 1):138-147

Research Service & Center for Innovation and Complex Chronic Healthcare, Edward Hines Jr., VA Hospital, 5000 S 5th Ave, MC 151 H, Hines, IL.

The purpose of this study is to characterize and describe the relationships between symptoms and functional impairment following mild traumatic brain injury (mTBI) and behavioral health conditions (BHCs) in order to inform evidence-based theories on why symptoms and functional impairments persist in some individuals but not others. This is a retrospective, multi-site, cross-sectional study utilizing data collected from a total of 289 Operation Iraqi Freedom/Operation Enduring Freedom Veterans who were classified into diagnostic groups using the symptom attribution and classification algorithm and the VA clinical reminder and comprehensive traumatic brain injury evaluation. The Neurobehavioral Symptom Inventory was used to assess mTBI symptom number and severity. Read More

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https://academic.oup.com/milmed/article/184/Supplement_1/138
Publisher Site
http://dx.doi.org/10.1093/milmed/usy306DOI Listing
March 2019
20 Reads

Biomechanics of Blast TBI With Time-Resolved Consecutive Primary, Secondary, and Tertiary Loads.

Mil Med 2019 03;184(Suppl 1):195-205

DoD Blast Program Coordinating Office, US Army MRMC, 504 Scott Street, Fort Detrick, MD.

Blast-induced traumatic brain injury (bTBI) has become a signature casualty of recent military operations. In spite of significant clinical and preclinical TBI research, current understanding of injury mechanisms and short- and long-term outcomes is limited. Mathematical models of bTBI biomechanics may help in better understanding of injury mechanisms and in the development of improved neuroprotective strategies. Read More

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http://dx.doi.org/10.1093/milmed/usy344DOI Listing
March 2019
4 Reads

Predictive Factors of Poor Prognosis After Surgical Management of Traumatic Acute Subdural Hematomas: A Single-Center Series.

World Neurosurg 2019 Jun 12;126:e944-e952. Epub 2019 Mar 12.

Department of Neurosurgery, North University Hospital, APHM, Aix Marseille University, Marseille, France.

Background: Traumatic acute subdural hematomas (ASDHs) showed the highest mortality of intracranial hematomas. The aim of the current study was to identify predictive factors of poor prognosis among patients who were operated on.

Methods: This is a single-center retrospective cohort study of 82 patients who underwent surgical evacuation of a traumatic ASDH between January 2009 and December 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193063
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http://dx.doi.org/10.1016/j.wneu.2019.02.194DOI Listing
June 2019
26 Reads

Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury: Examining Associations With Demographics, Healthcare Utilization, Institutionalization, and 1-Year Outcomes.

J Head Trauma Rehabil 2019 Jul/Aug;34(4):224-232

Departments of Physical Medicine & Rehabilitation (Drs Kumar, Olsen, and Wagner) and Epidemiology (Dr Kumar), Clinical and Translational Science Institute, Center for Neuroscience, and Safar Center for Resuscitation Research (Dr Wagner), University of Pittsburgh, Pennsylvania; Departments of Physical Medicine and Rehabilitation (Dr Juengst) and Rehabilitation Counseling (Dr Juengst), UT Southwestern, Dallas, Texas; Department of Rehabilitation and Human Performance and Department of Neurology, Icahn School of Medicine at Mount Sinai, New York (Dr Dams-O'Connor); Department of Communication Sciences and Disorders, Northeastern University, Boston, Massachusetts (Dr O'Neil-Pirozzi); Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts (Dr O'Neil-Pirozzi); and Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis (Dr Hammond).

Objectives: To assess the relationship of acute complications, preexisting chronic diseases, and substance abuse with clinical and functional outcomes among adults 50 years and older with moderate-to-severe traumatic brain injury (TBI).

Design: Prospective cohort study.

Participants: Adults 50 years and older with moderate-to-severe TBI (n = 2134). Read More

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http://dx.doi.org/10.1097/HTR.0000000000000470DOI Listing
March 2019
24 Reads
2.920 Impact Factor

Mortality Risk and Risk Factors in Patients with Posttraumatic Epilepsy: A Population-Based Cohort Study.

Int J Environ Res Public Health 2019 02 18;16(4). Epub 2019 Feb 18.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.

Use the National Health Insurance Research Database of Taiwan to determine whether patients with posttraumatic epilepsy (PTE) have an increased risk of mortality. Patients ≥20 years old ever admitted because of head injury (per International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 850⁻854 and 959.01) during 2000⁻2012 were enrolled into a traumatic brain injury (TBI) cohort. Read More

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http://dx.doi.org/10.3390/ijerph16040589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406809PMC
February 2019
15 Reads

Increased Risk of Dementia in Patients with Craniofacial Trauma: A Nationwide Population-Based Cohort Study.

World Neurosurg 2019 05 1;125:e563-e574. Epub 2019 Feb 1.

Division of Trauma Plastic Surgery, Department of Plastic and Reconstructive Surgery, Craniofacial Research Center, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Plastic Surgery, Xiamen Chang Gung Memorial Hospital, Xiamen, China. Electronic address:

Objective: The role of maxillofacial trauma in dementia risk is not well established. The aim of this study was to evaluate the association between craniofacial trauma, including facial bone fracture and traumatic brain injury (TBI), and dementia.

Methods: Using Taiwan's National Health Insurance Research Database, we identified 501,889 adults who had had ≥1 medical record of craniofacial trauma between 2000 and 2010 and did not have a dementia diagnosis at baseline. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.133DOI Listing
May 2019
5 Reads

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.

Epilepsy Res 2019 02 27;150:17-26. Epub 2018 Dec 27.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a National Institutes for Neurological Diseases and Stoke funded Centers-Without-Walls international multidisciplinary study aimed at preventing epileptogenesis. The preclinical biomarker discovery in EpiBios4Rx applies a multicenter study design to allow the number of animals that are required for adequate statistical power for the analysis to be studied in an efficient manner. Further, the use of multiple centers mimics the clinical trial situation, and therefore potentially the chance of successful clinical translation of the outcomes of the study. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818710PMC
February 2019
12 Reads

Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury.

J Transl Med 2018 12 13;16(1):353. Epub 2018 Dec 13.

School of Rehabilitation Medicine, Capital Medical University, No. 10 Jiaomen North Road, Fengtai District, Beijing, 100068, China.

Background: Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel management of male patients with chronic traumatic complete SCI in our centre and perform comparative analysis of the gut microbiota between our patients and healthy males.

Methods: A total of 43 male patients with chronic traumatic complete SCI (20 with quadriplegia and 23 with paraplegia) and 23 healthy male adults were enrolled. Read More

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https://translational-medicine.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12967-018-1735-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293533PMC
December 2018
26 Reads
3.930 Impact Factor

Surveillance Ultrasound in the Neuro Intensive Care Unit: Time to Deep Vein Thrombosis Diagnosis.

Neurocrit Care 2019 06;30(3):645-651

University Health System, San Antonio, TX, USA.

Background/objectives: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are complications of hospitalization leading to increased morbidity and mortality. Routine surveillance ultrasound has become common practice in some intensive care units (ICU) to detect DVT early and initiate anticoagulation, preventing complications. However, initiating anticoagulants for asymptomatic DVT treatment may increase risk of hemorrhage. Read More

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http://dx.doi.org/10.1007/s12028-018-0652-3DOI Listing
June 2019
2 Reads

[Neurotrauma as a factor of epileptogenesis].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10):90-92

Stavropol State Medical University, Stavropol, Russia.

The presented article deals with traumatic brain injury, which can cause convulsive seizures with the subsequent development of epilepsy, which is especially characteristic of young people. The problems of classification of posttraumatic epileptic seizures, development of their mechanisms, characteristics of diagnosis, as well as the stages of epileptogenesis leading to the development of traumatic epilepsy are considered. The variants of therapy are given in view of traumatic brain injury. Read More

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http://dx.doi.org/10.17116/jnevro201811810190DOI Listing
March 2019
32 Reads

Paroxysmal Sympathetic Hyperactivity After Severe Traumatic Brain Injury in Children: Prevalence, Risk Factors, and Outcome.

Pediatr Crit Care Med 2019 03;20(3):252-258

Department of Paediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada.

Objective: To describe paroxysmal sympathetic hyperactivity in pediatric patients with severe traumatic brain injury using the new consensus definition, the risk factors associated with developing paroxysmal sympathetic hyperactivity, and the outcomes associated with paroxysmal sympathetic hyperactivity.

Design: Retrospective cohort study.

Setting: Academic children's hospital PICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001811DOI Listing
March 2019
13 Reads

Risk of Mortality in Individuals with Hip Fracture and Traumatic Brain Injury.

J Am Geriatr Soc 2019 01 24;67(1):124-127. Epub 2018 Nov 24.

Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland.

Objectives: To estimate the prevalence of diagnosed traumatic brain injury (TBI) in individuals hospitalized with hip fracture and examine its association with all-cause mortality.

Design: Nested cohort study.

Setting: National sample of Medicare beneficiaries from 2006 to 2010. Read More

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http://dx.doi.org/10.1111/jgs.15661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436834PMC
January 2019
35 Reads

Concussion BASICS III: Serum biomarker changes following sport-related concussion.

Neurology 2018 12 7;91(23):e2133-e2143. Epub 2018 Nov 7.

From the Departments of Clinical and Health Psychology (B.M.A., R.M.B., A.M.S., G.H.), Neurology (R.M.B., S.T.D., J.R.C.), and Community Health and Family Medicine (J.R.C.), and University Athletic Association (J.K.B., D.N.D., J.R.C.), University of Florida, Gainesville; and Banyan Biomarkers, Inc. (R.L.H.), Alachua, FL.

Objective: To evaluate changes in serum biomarker concentrations (β-amyloid peptide 42 [Aβ], total tau, ubiquitin carboxy-terminal hydrolyzing enzyme L1, S100 calcium binding protein B [S100B], glial fibrillary acidic protein [GFAP], microtubule associated protein 2 [MAP2], and 2',3'-cyclic-nucleotide 3'-phosphodiesterase [CNPase]) after sport-related concussion (SRC) in a sample of collegiate athletes. Associations with clinical outcomes were also investigated.

Methods: Participants in this case-control study included 36 athletes (50% male, 61% white, aged 19. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006617DOI Listing
December 2018
72 Reads

Complications and Mortality Among Correctly Triaged and Undertriaged Severely Injured Older Adults With Traumatic Brain Injuries.

Authors:
Linda J Scheetz

J Trauma Nurs 2018 Nov/Dec;25(6):341-347

Department of Nursing, Lehman College and The Graduate Center, CUNY, Bronx, New York.

Determining differences in clinical outcomes of older adults treated at trauma centers (TCs) and nontrauma centers (NTCs) is imperative considering their persistent undertriage and the projected costs of fixing the problem. This study compared the incidence and predictors of complications and mortality among brain-injured older adults treated at TCs and NTCs. This secondary analysis of New York inpatient data included patients aged 55+ years, primary brain injury diagnosis, and acute care hospital admission. Read More

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http://Insights.ovid.com/crossref?an=00043860-201811000-0000
Publisher Site
http://dx.doi.org/10.1097/JTN.0000000000000399DOI Listing
March 2019
40 Reads

Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer Disease.

Clin Geriatr Med 2018 11 21;34(4):617-635. Epub 2018 Aug 21.

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, 1438 South Grand Boulevard, St Louis, MO 63104, USA.

Traumatic brain injury (TBI) is a major health and economic burden. With increasing aging population, this issue is expected to continue to rise. Neurodegenerative disorders are more common with aging population in general regardless of history of TBI. Read More

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http://dx.doi.org/10.1016/j.cger.2018.06.008DOI Listing
November 2018
12 Reads

A new hybrid classification system for traumatic brain injury which helps predict long-term consciousness: a single-center retrospective study.

Brain Inj 2018 16;32(13-14):1758-1765. Epub 2018 Oct 16.

b Department of Neurosurgery , Wuhan General Hospital of PLA , Wuhan , China.

Background: To develop and validate a refined traumatic brain injury (TBI) classification system to supplement the existing systems which have limited accuracy for predicting long-term consciousness recovery.

Methods: The refined classification system was developed using medical records of 527 patients according to clinical presentations within 12-24 hrs after injury. Multiple linear regression was applied to identify protective and risk factors for Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) score at 12-month follow-up. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2018.1
Publisher Site
http://dx.doi.org/10.1080/02699052.2018.1531146DOI Listing
September 2019
8 Reads
1.861 Impact Factor

Injuries to amateur participants in traditional bullfighting festivals.

Cir Esp 2019 Jan 12;97(1):34-39. Epub 2018 Oct 12.

Sección de Cirugía, Hospital Reina Sofía, Tudela, Navarra, España.

Introduction: To identify the different types of injuries occurred during activities for the general public involving bulls. We analyze the conditions in which these injuries occurred, radiological examinations performed, treatment and complications.

Method: We present a 10-year retrospective study examining 107 patients who came to the Emergency Department of our hospital with pathologies associated with bulls or bull calves over a period of 10years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0009739X183022
Publisher Site
http://dx.doi.org/10.1016/j.ciresp.2018.08.004DOI Listing
January 2019
40 Reads

Nationwide incidence and risk factors for posttraumatic seizures in children with traumatic brain injury.

J Neurosurg Pediatr 2018 Dec;22(6):684-693

2Department of Neurosurgery, University of Kansas Medical Center, Kansas City, Kansas.

OBJECTIVEPosttraumatic seizures (PTSs) are the most common complication following a traumatic brain injury (TBI) and may lead to posttraumatic epilepsy. PTS is well described in the adult literature but has not been studied extensively in children. Here, the authors utilized the largest nationwide registry of pediatric hospitalizations to report the national incidence, risk factors, and outcomes associated with PTS in pediatric TBI. Read More

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http://thejns.org/doi/10.3171/2018.6.PEDS1813
Publisher Site
http://dx.doi.org/10.3171/2018.6.PEDS1813DOI Listing
December 2018
38 Reads

Defining severe traumatic brain injury readmission rates and reasons in a rural state.

Trauma Surg Acute Care Open 2018 8;3(1):e000186. Epub 2018 Sep 8.

Department of Health Policy and Management, UAMS Medical Center, Little Rock, Arkansas, USA.

Background: Readmissions after a traumatic brain injury (TBI) have significant impact on long-term patient outcomes through interruption of rehabilitation. This study examined readmissions in a rural population, hypothesizing that readmitted patients after TBI will be older and have more comorbidities than those not readmitted.

Methods: Discharge data on all patients 15 years and older who were admitted to an Arkansas-based hospital for TBI were obtained from the Arkansas Hospital Discharge Data System from 2010 to 2014. Read More

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http://dx.doi.org/10.1136/tsaco-2018-000186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135415PMC
September 2018
7 Reads

Posttraumatic headache in pediatrics: an update and review.

Authors:
Heidi K Blume

Curr Opin Pediatr 2018 12;30(6):755-763

Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital and Research Institute, Seattle, Washington, USA.

Purpose Of Review: Headache following concussion and mild traumatic brain injury is very common in pediatrics. There is significant concern about appropriate management of acute and persistent headache following mild head injuries in children among affected youth, their families and care providers.

Recent Findings: The current article will review definitions and diagnoses of posttraumatic headache (PTHA), recent research regarding risk factors for persistence of postconcussion symptoms and headaches, current recommendations for the evaluation of youth with PTHA, recent data regarding efficacy of treatment options for PTHA, and current recommendations for the treatment of acute and persistent PTHA. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000691DOI Listing
December 2018
3 Reads

Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial.

Acta Anaesthesiol Scand 2019 02 21;63(2):200-207. Epub 2018 Aug 21.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background: Acute kidney injury (AKI) in traumatic brain injury (TBI) is poorly understood and it is unknown if it can be attenuated using erythropoietin (EPO).

Methods: Pre-planned analysis of patients included in the EPO-TBI (ClinicalTrials.gov NCT00987454) trial who were randomized to weekly EPO (40 000 units) or placebo (0. Read More

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http://dx.doi.org/10.1111/aas.13244DOI Listing
February 2019
11 Reads

Direct oral anticoagulants do not worsen traumatic brain injury after low-level falls in the elderly.

Surgery 2018 10 8;164(4):814-819. Epub 2018 Aug 8.

Saint Joseph Mercy Ann Arbor, Department of Pharmacy, Ann Arbor, MI. Electronic address:

Background: Falls are now the leading cause of trauma and represent the most common type of trauma in the elderly. The use of anticoagulants is increasing in older patients, but there are little data on outcomes after traumatic brain injury while anticoagulated with direct oral anticoagulants compared with warfarin. We hypothesized that anticoagulated patients would have a greater mortality and complications than nonanticoagulated patients, and patients on direct oral anticoagulants would have more fatal outcomes after low-level falls because of lack of reversal agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183032
Publisher Site
http://dx.doi.org/10.1016/j.surg.2018.05.060DOI Listing
October 2018
32 Reads

Imaging Post-Traumatic Headache.

Curr Pain Headache Rep 2018 Jul 30;22(10):64. Epub 2018 Jul 30.

Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.

Purpose Of Review: Headache is a frequent and debilitating symptom after mild traumatic brain injury, yet little is known about its pathophysiology and most effective treatments. The goal of this review is to summarize findings from imaging studies used during the clinical evaluation and research investigation of post-traumatic headache (PTH).

Recent Findings: There are no published recommendations or guidelines for when to acquire imaging studies of the head or neck in patients with PTH. Read More

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http://dx.doi.org/10.1007/s11916-018-0719-zDOI Listing
July 2018
37 Reads

Comparing disability between traumatic brain injury and spinal cord injury using the 12-item WHODAS 2.0 and the WHO minimal generic data set covering functioning and health.

Clin Rehabil 2018 Dec 2;32(12):1676-1683. Epub 2018 Jul 2.

3 Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Objective:: To compare disability between two patient groups using short validated tools based on International Classification of Functioning, Disability and Health (ICF).

Design:: Cross-sectional study.

Setting:: University hospital specialist outpatient clinic. Read More

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http://dx.doi.org/10.1177/0269215518785945DOI Listing
December 2018
4 Reads

Diffuse axonal injury (DAI) in moderate to severe head injured patients: Pure DAI vs. non-pure DAI.

Clin Neurol Neurosurg 2018 08 10;171:116-123. Epub 2018 Jun 10.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea; Division of Neurosurgical Critical Care, Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. Electronic address:

Objective: Diffuse axonal injury (DAI) is known to be associated with poor outcome. DAI often associates with other intracranial injuries but their distinct features have not been established. In this retrospective cohort study, we compared clinical outcomes between pure and non-pure DAI patients. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.06.011DOI Listing
August 2018
59 Reads