740 results match your criteria Classification and Complications of Traumatic Brain Injury


The impact of pre-morbid headaches on headache features and long-term health outcomes following traumatic brain injury: Insights from the American Registry for Migraine Research.

Headache 2022 May;62(5):566-576

Mayo Clinic, Phoenix, Arizona, USA.

Objective: To investigate the impact of having headaches prior to traumatic brain injury (TBI) on headache features and long-term patient health outcomes.

Background And Methods: This was an exploratory analysis of patients with TBI who were enrolled in the American Registry for Migraine Research (ARMR), a multicenter, prospective, longitudinal patient registry composed of patients with International Classification of Headache Disorders, 3rd edition (ICHD-3)-defined headache diagnoses. The ARMR study enrolled 2,707 patients between February 1, 2016 and May 6, 2020, 565 of whom qualified for this analysis. Read More

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Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders.

JAMA Netw Open 2022 04 1;5(4):e229478. Epub 2022 Apr 1.

Harvard Medical School, Boston, Massachusetts.

Importance: Increased risk of neurological and psychiatric conditions after traumatic brain injury (TBI) is well-defined. However, cardiovascular and endocrine comorbidity risk after TBI in individuals without these comorbidities and associations with post-TBI mortality have received little attention.

Objective: To assess the incidence of cardiovascular, endocrine, neurological, and psychiatric comorbidities in patients with mild TBI (mTBI) or moderate to severe TBI (msTBI) and analyze associations between post-TBI comorbidities and mortality. Read More

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Performance on, and correlates of, the Brief Visuospatial Memory Test-Revised after traumatic brain injury.

J Clin Exp Neuropsychol 2022 Feb 24;44(1):42-49. Epub 2022 Apr 24.

Jacobs School of Medicine and Behavioral Sciences, SUNY Buffalo, NY, USA.

Objective: This study investigated the performance on, and correlates of, the Brief Visuospatial Memory Test - Revised (BVMT-R) in patients with traumatic brain injury (TBI).

Methods: Participants included 100 patients with TBI and 100 demographically matched controls. We first used regression analysis to determine predictors of BVMT-R performance in the clinical group. Read More

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February 2022

Early Intervention of Perioperative Delirium in Older Patients (>60 years) with Hip Fracture: A Randomized Controlled Study.

Orthop Surg 2022 May 19;14(5):885-891. Epub 2022 Apr 19.

Wuhan Mental Health Center, Wuhan, China.

Objective: To explore the effect of early intervention for perioperative delirium in older (> 60 years) hip fracture patients.

Methods: This prospective study enrolled hip fracture patients aged ≥60 years who were admitted into our hospital between July 2011 and August 2019. Hip fractures were classified according to the Arbeitsgemeinschaft für Osteo-synthesefragen (AO) classification. Read More

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Compound elevated skull fractures: a retrospective descriptive study.

Br J Neurosurg 2022 Apr 13:1-6. Epub 2022 Apr 13.

Department of Neurosurgery, University of Kwa Zulu Natal, Durban, South Africa.

Background: Traumatic skull fractures have been traditionally classified into those that involve the base or vault with distinct entities linear or depressed. Compound elevated skull fracture is a newer entity with scanty reports in the literature.

Objective: To describe the clinical presentation, neuro-radiology findings by development of a classification system, medical and surgical management, and complications of patients with compound elevated skull fractures at a tertiary referral neurosurgical department. Read More

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Recovery of symptoms, neurocognitive and vestibular-ocular-motor function and academic ability after sports-related concussion (SRC) in university-aged student-athletes: a systematic review.

Brain Inj 2022 Mar 4;36(4):455-468. Epub 2022 Apr 4.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

Background: Physiological differences between a maturing and matured brain alters how Sports-Related Concussion (SRC) affects different age groups; therefore, a review specific to university-aged student-athletes is needed.

Objectives: Determine time to recovery for symptom burden, neurocognitive and Vestibular-Ocular-Motor (VOM) function and academic impact in university-aged student-athletes.

Methods: Searches were conducted in PubMed, SpringerLink, PsycINFO, Science Direct, Scopus, Cochrane, Web of Science and EMBASE. Read More

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Post-traumatic headaches and vision: A review.

NeuroRehabilitation 2022 ;50(3):297-308

Ophthalmology & Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Post-traumatic headache is the most common sequela of brain injury and can last months or years after the damaging event. Many headache types are associated with visual concerns also known to stem from concussion.

Objectives: To describe the various headache types seen after head injury and demonstrate how they impact or are impacted by the visual system. Read More

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"Decision tree analysis for assessing the risk of post-traumatic haemorrhage after mild traumatic brain injury in patients on oral anticoagulant therapy".

BMC Emerg Med 2022 03 24;22(1):47. Epub 2022 Mar 24.

Academy of Emergency Medicine and Care (AcEMC), Pavia, Italy.

Background: The presence of oral anticoagulant therapy (OAT) alone, regardless of patient condition, is an indication for CT imaging in patients with mild traumatic brain injury (MTBI). Currently, no specific clinical decision rules are available for OAT patients. The aim of the study was to identify which clinical risk factors easily identifiable at first ED evaluation may be associated with an increased risk of post-traumatic intracranial haemorrhage (ICH) in OAT patients who suffered an MTBI. Read More

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Compliance with venous thromboembolism chemoprophylaxis guidelines in non-operative traumatic brain injury.

Clin Neurol Neurosurg 2022 04 15;215:107212. Epub 2022 Mar 15.

Department of Neurological Surgery, Mount Sinai Health System, New York, NY, USA.

Objective: To determine the level of compliance of The American College of Surgeons (ACS) Trauma Quality Improvement Program (TQIP) for initiation of venous thromboembolism (VTE) prophylaxis after non-operative traumatic brain injury (TBI) and the explanation for the deviations.

Methods: A retrospective review from May 2018 to February 2020 in a Level II trauma center for patients with TBI and length of stay of more than 24 h. We performed an analysis of overall and subgroup compliance with guidelines. Read More

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Posttraumatic Amnesia: A Systematic Review and Meta-Analysis. Proposal for a New Severity Classification.

World Neurosurg 2022 Jun 11;162:e369-e393. Epub 2022 Mar 11.

School of Medicine and Dentistry, James Cook University, Douglas, Townsville, Queensland, Australia; Department of Neurosurgery, The University Townsville Hospital, Douglas, Townsville, Queensland, Australia. Electronic address:

Background: Posttraumatic amnesia (PTA) duration is used to predict outcome after traumatic brain injury (TBI): however, no meta-analysis exists.

Methods: A systematic review was performed following PRISMA reporting guidelines. The databases Scopus-1966, PubMed/MEDLINE, CINAHL, PsycINFO, and Embase were searched for relevant texts. Read More

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Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury.

JAMA Neurol 2022 04;79(4):334-341

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Importance: Early posttraumatic seizures (EPS) that may occur following a traumatic brain injury (TBI) are associated with poorer outcomes and development of posttraumatic epilepsy (PTE).

Objective: To evaluate risk factors for EPS, associated morbidity and mortality, and contribution to PTE.

Design, Setting, And Participants: Data were collected from an Australian registry-based cohort study of adults (age ≥18 years) with moderate to severe TBI from January 2005 to December 2019, with 2-year follow-up. Read More

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Beliefs affecting concussion reporting among military cadets: advanced observations through machine learning.

Brain Inj 2022 01 8;36(2):156-165. Epub 2022 Feb 8.

Department of Behavioral Science and Leadership, United States Air Force Academy, USAF, Colorado Springs, CO, USA.

Background: Untreated concussions are an important health concern. The number of concussions sustained each year is difficult to pinpoint due to diverse reporting routes and many people not reporting. A growing body of literature investigates the motivations for concussion under-reporting, proposing ties with knowledge of concussion outcomes and concussion culture. Read More

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January 2022

Clinical features of dementia cases ascertained by ICD coding in LIMBIC-CENC multicenter study of mild traumatic brain injury.

Brain Inj 2022 Apr 2;36(5):644-651. Epub 2022 Feb 2.

Department of Physical Medicine and Rehabilitation (PM&R), School of Medicine, Virginia Commonwealth University, and Central Virginia VA Healthcare System, Richmond, Virginia, USA.

Objective: Describe dementia cases identified through International Classification of Diseases (ICD) coding in the Long-term Impact of Military-relevant Brain Injury Consortium - Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter prospective longitudinal study (PLS) of mild traumatic brain injury (mTBI).

Design: Descriptive case series using cross-sectional data.

Methods: Veterans Affairs (VA) health system data including ICD codes were obtained for 1563 PLS participants through the VA Informatics and Computing Infrastructure (VINCI). Read More

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Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review.

Neurosurgery 2022 02;90(2):170-179

Department of Medicine, University Division of Anaesthesia, University of Cambridge, Cambridge, UK.

Background: Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear.

Objective: To perform a systematic review of the relationship between blood biomarkers and intracranial lesion types, intracranial lesion injury patterns, volume/number of intracranial lesions, and imaging classification systems. Read More

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February 2022

A multicenter cohort study of early complications after cranioplasty: results of the German Cranial Reconstruction Registry.

J Neurosurg 2021 Dec 17:1-8. Epub 2021 Dec 17.

12Department of Neurosurgery, Georg-August-University, Goettingen, Germany.

Objective: Cranioplasty (CP) is a crucial procedure after decompressive craniectomy and has a significant impact on neurological improvement. Although CP is considered a standard neurosurgical procedure, inconsistent data on surgery-related complications after CP are available. To address this topic, the authors analyzed 502 patients in a prospective multicenter database (German Cranial Reconstruction Registry) with regard to early surgery-related complications. Read More

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December 2021

Preventable Etiologies of Epilepsies in Saudi Arabia: A Tertiary Care Experience.

Prim Care Companion CNS Disord 2021 Dec 9;23(6). Epub 2021 Dec 9.

Department of Neurology, College of Medicine, Imam Abdul Rahman Bin Faisal University, King Fahd University Hospital, Dammam, Saudi Arabia.

To determine the etiologies of epilepsy in a cohort of patients using the International League Against Epilepsy 2017 classification system and to determine frequencies of preventable causes and their clinical characteristics.

Epileptic patients in neurology clinics at a tertiary care hospital were prospectively recruited from June 1, 2018, to November 30, 2018. Patients were divided according to their respective etiologic categories. Read More

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December 2021

Functional Outcome After Primary Decompressive Craniectomy for Acute Subdural Hematoma in Severe Traumatic Brain Injury.

Turk Neurosurg 2022 ;32(2):211-220

Zagazig University, Faculty of Medicine, Department of Neurosurgery, Egypt.

Aim: To evaluate the impact of primary decompressive craniectomy (DC) on the functional outcome in patients with post traumatic acute subdural hematoma (SDH).

Material And Methods: A retrospective cohort analysis of 92 patients with post traumatic acute SDH who underwent primary DC and evacuation of SDH. The primary outcome variable is Glasgow outcome scale at 6 months follow up, while exposure variables are demographic data (age and gender), initial Glasgow coma scale, Marshall Classification Score of traumatic brain injury, midline shift, side of the lesion, surgery related complications and time of cranioplasty. Read More

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Traumatic brain injury in the elderly with high Glasgow coma scale and low injury severity scores: Factors influencing outcomes.

Am J Emerg Med 2022 Jan 8;51:354-357. Epub 2021 Nov 8.

Ascension Genesys Hospital, Department of Clinical & Academic Research, Grand Blanc, MI, United States of America.

Background: Current trauma activation guidelines do not clearly address age as a risk factor when leveling trauma patients. Glasgow coma scale (GCS) and mode of injury play a major role in leveling trauma patients. We studied the above relationship in our elderly patients presenting with traumatic head injury. Read More

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January 2022

The radiological interpretation of possible microbleeds after moderate or severe traumatic brain injury: a longitudinal study.

Neuroradiology 2022 Jun 31;64(6):1145-1156. Epub 2021 Oct 31.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Introduction: In order to augment the certainty of the radiological interpretation of "possible microbleeds" after traumatic brain injury (TBI), we assessed their longitudinal evolution on 3-T SWI in patients with moderate/severe TBI.

Methods: Standardized 3-T SWI and T1-weighted imaging were obtained 3 and 26 weeks after TBI in 31 patients. Their microbleeds were computer-aided detected and classified by a neuroradiologist as no, possible, or definite at baseline and follow-up, separately (single-scan evaluation). Read More

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Proteomic Discovery of Noninvasive Biomarkers Associated With Sport-Related Concussions.

Neurology 2022 01 21;98(2):e186-e198. Epub 2021 Oct 21.

From the Vascular Biology Program (C.C.D., S.V., K.K., M.A.M.), Division of Sports Medicine (D.R.H., W.P.M.), Department of Orthopaedics, Brain Injury Center (D.R.H., R.M., W.P.M.), Sports Concussion Clinic (R.M.), Division of Sports Medicine, Division of Emergency Medicine (R.M.), Department of Urology (R.S.L., J.W.F.), Department of Anesthesia (D.Z.), and Department of Surgery (M.A.M.), Boston Children's Hospital; The Micheli Center for Sports Injury Prevention (D.R.H., R.M., W.P.M.), Waltham, MA; Sports Medicine Center (D.R.H.), Children's Hospital Colorado; Department of Orthopedics (D.R.H.), University of Colorado School of Medicine, Aurora; Departments of Pediatrics (W.P.M.), and Orthopaedic Surgery (W.P.M.), and Surgery (R.S.L., J.W.F., D.Z., M.A.M.), Harvard Medical School; and Harvard Sports Medicine (F.W., B.B.), Boston, MA.

Background And Objectives: Sport-related concussions affect millions of individuals across the United States each year, and current techniques to diagnose and monitor them rely largely on subjective measures. Our goal was to discover and validate objective, quantifiable noninvasive biomarkers with the potential to be used in sport-related concussion diagnosis.

Methods: Urine samples from a convenience series of healthy control collegiate athletes who had not sustained a concussion and athletes who sustained a concussion as diagnosed by a sports medicine physician within 7 days were collected prospectively and studied. Read More

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January 2022

Rapid detection of platelet inhibition and dysfunction in traumatic brain injury: A prospective observational study.

J Trauma Acute Care Surg 2022 01;92(1):167-176

From the Department of Surgery (J.A., M.Z., A.H., H.P., M.D.N.), University of Pittsburgh Medical Center; University of Pittsburgh School of Medicine (I.C.), Pittsburgh, Pennsylvania; Department of Surgery (J.O.J.), University of Alabama at Birmingham, Birmingham, Alabama; and Department of Neurological Surgery (D.O.O.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: Rapid platelet function testing is frequently used to determine platelet function in patients with traumatic intracranial hemorrhage (tICH). Accuracy and clinical significance of decreased platelet response detected by these tests is not well understood. We sought to determine whether VerifyNow and whole blood aggregometry (WBA) can detect poor platelet response and to elucidate its clinical significance for tICH patients. Read More

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January 2022

Sport-Specific Increased Risk of Anterior Cruciate Ligament Injury Following a Concussion in Collegiate Female Lacrosse.

Curr Sports Med Rep 2021 Oct;20(10):520-524

Department of Psychology, Davidson College, Davidson, NC.

Abstract: Poor neurocognitive performance has been associated with a greater risk of musculoskeletal injury, and anterior cruciate ligament (ACL) injury prevention protocols include exercises to improve neuromuscular control. Research shows that a concussion elevates the risk for subsequent lower-extremity injury, because concussions lead to lower neurocognitive performance. Studies have been conducted using data within individual male sports, such as football and rugby, or across collegiate sports in aggregate; no study has focused on women's sports. Read More

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October 2021

Measuring the effects of institutional pediatric traumatic brain injury volume on outcomes for rural-dwelling children.

J Neurosurg Pediatr 2021 Oct 1:1-9. Epub 2021 Oct 1.

4Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

Objective: Rural-dwelling children may suffer worse pediatric traumatic brain injury (TBI) outcomes due to distance from and accessibility to high-volume trauma centers. This study aimed to compare the impacts of institutional TBI volume and sociodemographics on outcomes between rural- and urban-dwelling children.

Methods: This retrospective study identified patients 0-19 years of age with ICD-9 codes for TBI in the 2012-2015 National Inpatient Sample database. Read More

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October 2021

Eastern Association for the Surgery of Trauma Multicenter Trial: Comparison of pre-injury antithrombotic use and reversal strategies among severe traumatic brain injury patients.

J Trauma Acute Care Surg 2022 01;92(1):88-92

From the Department of Surgery (B.K.Y., M.C., A.J.K.), University of Florida College of Medicine-Jacksonville, Jacksonville, Florida; Trauma Division (D.M.T.), Our Lady of the Lake RMC, Baton Rouge, Louisiana; Department of Surgery (S.T.), Tulane School of Medicine, New Orleans, Louisiana; Department of Surgery (T.J.S.), UC Health Memorial Hospital, Colorado Springs, Colorado; Department of Surgery (M.R.N., F.H.P.), Allegheny Health Network, Pittsburgh, Pennsylvania; Division of Trauma/Acute Care Surgery (N.B.), Tufts Medical Center, Boston, Massachusetts; Department of Surgery (K.M., M.B.), Loma Linda University Medical Center, Loma Linda, California; Department of Surgery (A.W.O.), Reading Hospital Tower Health, Reading, Pennsylvania; Department of Surgery (A.R.), Crozer Keystone Health System, Upland, Pennsylvania; Tulane University Medical School (K.D.N.), New Orleans, Louisiana; Department of Surgery (M.M.C.), Medical City Plano, Plano, Texas; Department of Surgery (J.M.H., K.L.L.), Via Christi Hospitals Wichita, Wichita, Kansas; Department of Surgery (L.L., R.B.), St. Mary's Medical Center, West Palm Beach, Florida; Department of Surgery (D.C.C.), Maine Medical Center, Portland, Maine; Department of Surgery (J.D.B., D.R.M.), Broward Health Medical Center, Fort Lauderdale, Florida; Department of Surgery (T.Z.H.), Indiana University School of Medicine, Eskenazi Health, Indianapolis, Indiana.

Background: Trauma teams are often faced with patients on antithrombotic (AT) drugs, which is challenging when bleeding occurs. We sought to compare the effects of different AT medications on head injury severity and hypothesized that AT reversal would not improve mortality in severe traumatic brain injury (TBI) patients.

Methods: An Eastern Association for the Surgery of Trauma-sponsored prospective, multicentered, observational study of 15 trauma centers was performed. Read More

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January 2022

Analysis of changes in the volume of edema around brain contusions and the influencing factors: A single-center, retrospective, observational study.

Medicine (Baltimore) 2021 Sep;100(38):e27246

Department of Neurosurgery of the 900th Hospital, Fuzong Clinical Medical School of Fujian Medical University, Fuzhou, Fujian Province, China.

Abstract: Traumatic brain injury (TBI), a common neurosurgical condition, has well-known treatment guidelines. However, the mechanisms underlying the varying severity of brain edema secondary to TBI are largely unknown, leading to controversial treatments.This study seeks to measure edema volumes around brain contusions in different regions, analyze factors related to differences in edema volume and provide a theoretical basis for brain edema treatment. Read More

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September 2021

Cytotoxic Edema Associated with Hemorrhage Predicts Poor Outcome after Traumatic Brain Injury.

J Neurotrauma 2021 11;38(22):3107-3118

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Magnetic resonance imaging (MRI) is used rarely in the acute evaluation of traumatic brain injury (TBI) but may identify findings of clinical importance not detected by computed tomography (CT). We aimed to characterize the association of cytotoxic edema and hemorrhage, including traumatic microbleeds, on MRI obtained within hours of acute head trauma and investigated the relationship to clinical outcomes. Patients prospectively enrolled in the Traumatic Head Injury Neuroimaging Classification study (NCT01132937) with evidence of diffusion-related findings or hemorrhage on neuroimaging were included. Read More

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November 2021

Thromboembolic complications among multiple injured patients with pelvic injuries: identifying risk factors for possible patient-tailored prophylaxis.

World J Emerg Surg 2021 08 26;16(1):42. Epub 2021 Aug 26.

Department of Orthopedics and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.

Background: Patients with pelvic and/or acetabular fractures are at high risk of developing thromboembolic (TE) complications. In our study we investigate TE complications and the potential negative effects of concomitant pelvic or acetabular injuries in multiple injured patients according to pelvic/acetabular injury severity and fracture classification.

Methods: The TraumaRegister DGU® was analyzed between 2010 and 2019. Read More

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Photophobia Associated with Traumatic Brain Injury: A Systematic Review and Meta-analysis.

Optom Vis Sci 2021 08;98(8):891-900

Department of Defense/Veterans Affairs Vision Center of Excellence, Bethesda, Maryland.

Significance: This study reports the prevalence and relative risk of photophobia in patients with traumatic brain injury (TBI).

Objectives: This study aimed to conduct a systematic review and meta-analysis to determine the prevalence and relative risk of photophobia in patients with TBI.

Data Sources: Three databases were used for literature search: PubMed, EMBASE, and Cochrane Library. Read More

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Long-term cognitive deficits after traumatic brain injury associated with microglia activation.

Clin Immunol 2021 09 30;230:108815. Epub 2021 Jul 30.

Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon; Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Lebanon. Electronic address:

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases of the central nervous system. We hypothesize that microglia may play a beneficial or detrimental role in TBI depending on their state of activation and duration. Read More

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September 2021

Local Skull Thinning is One of Risks for the Ruptured Arachnoid Cysts With Chronic Subdural Hematoma in Adults: Thirty-two Clinical Reports.

J Craniofac Surg 2022 Mar-Apr 01;33(2):e102-e105

Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objective: Chronic subdural hematomas (CSDHs) in young people are uncommon, rupture of arachnoid cysts (ACs) is one of the reasons for young patients. The detailed features of CSDHs associated with ACs remain poorly understood. The objective of this study is to analyze the characteristics of risks for the rupture of ACs with CSDH in Adults. Read More

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