330,265 results match your criteria Cirrhosis


Incretin-based Therapies for the Management of NAFLD in Patients with Type 2 Diabetes.

Authors:
Kenneth Cusi

Hepatology 2019 Apr 21. Epub 2019 Apr 21.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL.

The prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2DM) is believed to be ~70% and that of advanced fibrosis ~20%. Given the magnitude of the problem, there is a real sense of urgency to identify the best pharmacological approach for to treat both diabetes and NASH in this population. Vitamin E is recommended for patients with biopsy-proven NASH without diabetes but did not have similar efficacy in a recent proof-of-concept RCT in patients with T2DM. Read More

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http://dx.doi.org/10.1002/hep.30670DOI Listing

Impact of CFTR-modulating drugs on GH-IGF-1 axis impairment in adult patients with cystic fibrosis.

J Endocrinol Invest 2019 Apr 20. Epub 2019 Apr 20.

Section of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy.

Introduction: A new class of drugs in the treatment of cystic fibrosis (CF) includes two agents: lumacaftor, which corrects CFTR channel protein, and ivacaftor, which increases CFTR channel activity. In our previous study we recruited 50 stable adults with CF and 16 of them showed growth hormone deficit (GHD): 7 patients severe and 9 patients partial GHD.

Material And Methods: We decided to re-evaluate ten patients with the GHRH + arginine test of whom only five were treated with lumacaftor/ivacaftor. Read More

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http://dx.doi.org/10.1007/s40618-019-01051-4DOI Listing

Pleuroparenchymal fibroelastosis (PPFE) treated with lung transplantation and review of the literature.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

A 26-year-old woman presented with a 15-year history of non-progressive dyspnoea. Chest imaging showed bilateral apical pleural and parenchymal scarring, pleural thickening and bronchiectasis. Pulmonary function tests showed a moderate restrictive defect. Read More

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http://dx.doi.org/10.1136/bcr-2019-229402DOI Listing

Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Loeffler endocarditis is an uncommon restrictive cardiomyopathy associated with eosinophilia and endomyocardial fibrosis causing diastolic restriction, predominantly involving the right ventricle. Cardiac MRI plays a crucial role in early detection of disease. Early disease usually responds well to corticosteroids. Read More

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http://dx.doi.org/10.1136/bcr-2018-227642DOI Listing

Adherence to nutritional supplementation in cystic fibrosis.

J Pediatr Nurs 2019 Apr 18;47:18-22. Epub 2019 Apr 18.

Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA; University of Pennsylvania Perelman School of Medicine, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA.

Purpose: The purpose of this study was to examine patterns of adherence to a novel dietary supplement in pediatric cystic fibrosis. Adherence to dietary supplementation in cystic fibrosis is challenging, and examination of patterns of adherence behavior over time is needed to better characterize subgroups of patients who need self-management support.

Design And Methods: We prospectively examined adherence to Lym-X-Sorb™ (LXS), an organized lipid matrix dietary supplementation for patients with cystic fibrosis (CF) and pancreatic insufficiency (PI), over a 12-month period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08825963183057
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http://dx.doi.org/10.1016/j.pedn.2019.04.011DOI Listing

Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell.

Int Immunopharmacol 2019 Apr 18;72:330-338. Epub 2019 Apr 18.

Department of Pharmacy, The Second Affiliated Hospital Of Bengbu Medical College, Hongye Road, Bengbu 233000, China. Electronic address:

Liver fibrosis is a continuous wound-healing process, which is due to excessive deposition of extracellular matrix (ECM) caused by activated Hepatic Stellate Cells (HSCs). Geniposide (GP) is a naturally occurring iridoid glucoside and is extracted from Gardenia jasminoides Ellis. GP has long been speculated to play a vital role in the treatment of hyperlipidemia and fatty liver. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.016DOI Listing

Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes.

Colloids Surf B Biointerfaces 2019 Apr 14;179:453-461. Epub 2019 Apr 14.

Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

We developed a facile fabrication method for preparing poly(ethylene glycol)(PEG)-coated poly (lactic-co-glycolic acid) (PLGA) microspheres with homogeneous size distribution via a combination of mPEG-b-PLGA and Shirasu Porous Glass membrane emulsification. Subsequently, extracellular matrix (ECM) degrading enzymes, collagenase (COLase) or hyaluronidase (HAse) were loaded into the microspheres. The obtained microspheres exhibited a sustained release of COLase or HAse over 10 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193025
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http://dx.doi.org/10.1016/j.colsurfb.2019.04.028DOI Listing
April 2019
4 Reads

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.

Phytomedicine 2018 Nov 19;58:152764. Epub 2018 Nov 19.

Medical College of China Three Gorges University, Yichang 443002, PR China; Yichang Key Laboratory of ischemic cardiovascular and cerebrovascular disease translational medicine (Three Gorges University), Yichang 443000, PR China. Electronic address:

Background: Myocardial fibrosis is a common pathological manifestation of many cardiovascular diseases at the end stage. Autophagy has been demonstrated to play a protective role in the cardiac fibrosis. Our previous studies have demonstrated that the Saponins from Panax japonicus effectively ameliorated the degree of fibrosis in rat acute myocardial ischemia injury model though the mechanisms are not clear. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.024DOI Listing
November 2018

Robotic complete excision of sacrocolpopexy mesh. Standardized technique.

J Minim Invasive Gynecol 2019 Apr 18. Epub 2019 Apr 18.

From the Department of Gynecology. Mayo Clinic, Phoenix, Arizona.

Study Objective: Description of a standardized technique for robotic complete excision of sacrocolpopexy mesh.

Design: Step by Step video demonstration of the technique.

Setting: Tertiary care academic hospital PATIENTS: Three patients with persistent pain following sacrocolpopexy mesh insertion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15534650193019
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http://dx.doi.org/10.1016/j.jmig.2019.04.016DOI Listing
April 2019
1 Read

Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway.

Toxicol Appl Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China. Electronic address:

Multi-walled carbon nanotubes (MWCNTs) have been developed with numerous beneficial applications. However, rodent models demonstrate that exposure to MWCNTs via respiratory pathways results in pulmonary fibrosis. Therefore, they could elicit a potential risk of pulmonary fibrosis in humans due to occupational or consumer exposure. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.013DOI Listing

Myostatin regulates the fibrogenic phenotype of hepatic stellate cells via c-jun N-terminal kinase activation.

Dig Liver Dis 2019 Apr 17. Epub 2019 Apr 17.

Dipartimento di Medicina Sperimentale Clinica, University of Florence, Florence, Italy; Research Center Denothe, University of Florence, Florence, Italy. Electronic address:

Background & Aims: Myostatin is mainly expressed in skeletal muscle, where it negatively regulates trophism. This myokine is implicated in the pathophysiology of nonalcoholic steatohepatitis, an emerging cause of liver fibrosis. In this study we explored the effects of myostatin on the biology of hepatic stellate cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193011
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http://dx.doi.org/10.1016/j.dld.2019.03.002DOI Listing
April 2019
1 Read

Cystic fibrosis screen positive inconclusive diagnosis (CFSPID): Experience in Tuscany, Italy.

J Cyst Fibros 2019 Apr 17. Epub 2019 Apr 17.

Cystic Fibrosis Centre, Department of Paediatric Medicine, Anna Meyer Children's University Hospital, Florence, Italy.

Objective: The implementation of cystic fibrosis (CF) newborn screening (NBS) has led to identification of infants with a positive NBS test but inconclusive diagnosis classified as "CF screen positive, inconclusive diagnosis" (CFSPID). We retrospectively evaluated the prevalence and clinical outcome of CFSPID infants diagnosed by 2 NBS algorithms in the period from 2011 to 2016 in the Tuscany region of Italy.

Methods: In 2011-2016, we assessed the diagnostic impact of DNA analysis on the NBS 4-tier algorithm [immunoreactive trypsin (IRT) - meconium lactase - IRT2 - sweat chloride (SC)]. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.002DOI Listing

Left Ventricular Noncompaction: Better Alone Than in Bad Company.

JACC Cardiovasc Imaging 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.jcmg.2019.03.012DOI Listing

The role of fibroblast - Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease.

J Mol Cell Cardiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Internal Medicine and Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:

Aims: Atrial contractile dysfunction is associated with increased mortality in heart failure (HF). We have shown previously that a metabolic syndrome-based model of HFpEF and a model of hypertensive heart disease (HHD) have impaired left atrial (LA) function in vivo (rat). In this study we postulate, that left atrial cardiomyocyte (CM) and cardiac fibroblast (CF) paracrine interaction related to the inositol 1,4,5-trisphosphate signalling cascade is pivotal for the manifestation of atrial mechanical dysfunction in HF and that quantitative atrial remodeling is highly disease-dependent. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.016DOI Listing

The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study.

J Clin Neurosci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

The epidemiologic trend of acute bacterial meningitis can change more dramatically than any other bacterial disease, and a decrease in spontaneous adult bacterial meningitis (ABM) has been noted in serial studies of the epidemiologic trend of ABM in Taiwan. The purpose of this study was to analyze the clinical characteristics, laboratory data and therapeutic outcomes of 149 patients with spontaneous Gram-negative (G(-)) ABM collected during a study period of 31 years (1986-2016). The 149 patients included 107 men and 42 women, aged 18-86 years. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.047DOI Listing

Transarterial chemoembolization versus best supportive care for patients with hepatocellular carcinoma with portal vein tumor thrombus:a multicenter study.

Eur J Surg Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China; Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning, China. Electronic address:

Background: This study aims to compare the efficacy and safety of treatment after transarterial chemoembolization(TACE) with best supportive care (BSC) in patients with hepatocellular carcinoma (HCC) with PVTT.

Methods: This retrospective study was conducted on 1,040 patients with HCC with PVTT who were treated either with TACE (n = 675) or BSC (n = 365). BSC did not include sorafenib. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.042DOI Listing

Clinical and biochemical footprints of inherited metabolic diseases. II. Metabolic liver diseases.

Mol Genet Metab 2019 Apr 12. Epub 2019 Apr 12.

Dietmar-Hopp Metabolic Center, University Children's Hospital, Heidelberg, Germany; Division of Metabolism, Children's Hospital, Zürich, Switzerland. Electronic address:

Inherited metabolic diseases account for about one third of pediatric patients with hepatomegaly, acute liver failure, cirrhosis or cholestasis. Specifically for pediatric acute liver failure, they account for 10-15% of cases, with a mortality of 22-65%. The percentage of acute liver failure caused by an inherited metabolic disease in children <2-3 years of age is even higher, ranging from a third to half of all cases. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.04.002DOI Listing
April 2019
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Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage.

Homeopathy 2019 Apr 20. Epub 2019 Apr 20.

Laboratoire d'Hématologie, UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.

Background:  Aspirin is the oldest and possibly the most widely used pharmacologically active substance still used in allopathic medicine. Its effect on fever and inflammation has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested for many years in the University of Bordeaux, in humans as well as in animal models. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1677495
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http://dx.doi.org/10.1055/s-0038-1677495DOI Listing
April 2019
1 Read

Predicting clinical outcomes of cirrhosis patients with hepatic encephalopathy from the fecal microbiome.

Cell Mol Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background & Aims: Gut dysbiosis plays a role in hepatic encephalopathy (HE), while its relationship at the acute episode of overt HE (AHE), the disease progression and clinical outcomes remains unclear. We aimed to identify AHE-specific microbiome and its association to patients' outcomes.

Methods: We profiled fecal microbiome changes for a cohort of 62 patients with cirrhosis and AHE i) before treatment, ii) 2-3 days after medication and iii) 2-3 months after recovery, and three control cohorts i) healthy individuals, patients with ii) compensated or iii) decompensated cirrhosis. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.008DOI Listing
April 2019
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Editorial: Simple clinical tools to predict decompensation in patients with compensated cirrhosis. An unmet need.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Digestive Diseases Section. Yale University School of Medicine, New Haven, CT. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.026DOI Listing

Increased Risk of Death in First Year After Liver Transplantation Among Patients with Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan, United States.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.033DOI Listing
April 2019
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Cirrhosis and the Acute Kidney Injury/Chronic Kidney Disease Continuum: The Path Chosen Matters.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas TX.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.030DOI Listing
April 2019
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.

Matrix Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Virginia, Charlottesville, VA, USA. Electronic address:

The extracellular matrix (ECM) microenvironment is increasingly implicated in the instruction of pathologically relevant cell behaviors, from aberrant transdifferentation to invasion and beyond. Indeed, pathologic ECMs possess a panoply of alterations that provide deleterious instructions to resident cells. Here we demonstrate the precise manner in which the ECM protein fibronectin (FN) undergoes the posttranslational modification citrullination in response to peptidyl-arginine deiminase (PAD), an enzyme associated with innate immune cell activity and implicated in systemic ECM-centric diseases, like cancer, fibrosis and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.matbio.2019.04.002DOI Listing

Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats.

J Ethnopharmacol 2019 Apr 17:111888. Epub 2019 Apr 17.

Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Ethnopharmacological Relevance: Fuzheng-Huayu formula (FZHY) is traditionally used to treat liver fibrosis in clinic. The study was conducted to investigate the metabolic mechanisms of FZHY against liver fibrosis in rats.

Materials And Methods: Rats with CCl -induced liver fibrosis were treated with FZHY and its components, including amygdalin, cordyceps polysaccharide and gypenoside, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183400
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http://dx.doi.org/10.1016/j.jep.2019.111888DOI Listing
April 2019
1 Read

Osteopontin-derived synthetic peptide SVVYGLR has potent utility in the functional regeneration of oral and maxillofacial skeletal muscles.

Peptides 2019 Apr 17. Epub 2019 Apr 17.

The 1st Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamada-oka, Suita, Osaka, 565-0871, Japan. Electronic address:

Oral and maxillofacial skeletal muscles are critical for oral motor functions, and severe damage to these muscles by trauma or surgery may lead to persistent functional impairment. This study investigated the effects of SVVYGLR (SV) peptide, a thrombin-cleaved osteopontin-derived motif, on histopathological wound healing and functional repair after severe injury of skeletal muscles. A rat model of volumetric muscle loss bilateral masseter muscle was developed. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.013DOI Listing

An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis.

J Control Release 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Clinical Pharmacy and Adverse Drug Reaction; Department of Pharmacy, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Activation of hepatic stellate cells (HSCs) contributes to the development of liver fibrosis. Because of a relatively small population of HSCs in the liver and the lack of specific membrane targeting proteins, HSC-targeted therapy remains a major clinical challenge. Here we first showed that a hallmark of activated HSC (aHSC) is their increased expression of integrin αvβ3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.022DOI Listing
April 2019
5 Reads

Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Aims And Methods: Acute myocardial infarction (AMI) is a common cardiovascular disease with high mortality. Astragaloside IV (AS-IV) was reported to have cardioprotective effect after AMI. We hypothesize that the cardioprotective role of AS-IV is exerted by enhancing angiogenesis via regulating PTEN/PI3K/Akt signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.040DOI Listing
April 2019
2 Reads

Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.

Objective: Connective tissue growth factor (CTGF) is an important regulator of fibrogenesis in many organs. This study evaluated the interrelationship among adipose tissue CTGF expression, fat mass, and insulin resistance in humans.

Methods: This study examined (1) CTGF gene expression in human subcutaneous preadipocytes before and after inducing adipogenesis; (2) relationships among abdominal subcutaneous adipose tissue CTGF gene expression, body fat mass, and indices of insulin sensitivity, including the hepatic insulin sensitivity index and the hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotope glucose tracer infusion, in 72 people who had marked differences in adiposity and insulin sensitivity; (3) localization of CTGF protein in subcutaneous adipose tissue; and (4) effect of progressive (5%, 11%, and 16%) weight loss on adipose tissue CTGF gene expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22463
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http://dx.doi.org/10.1002/oby.22463DOI Listing
April 2019
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Drugs in Development for Acute Kidney Injury.

Drugs 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, Department of Medicine, University of Virginia Health System, 135 Hospital Drive, Suite 1031, Charlottesville, VA, 22908, USA.

The care of patients with acute kidney injury (AKI) has been limited due to the lack of effective therapeutics that can either prevent AKI during high-risk situations or treat AKI once established. A revolution in the scientific understanding of the pathogenesis of AKI has led to the identification of potential therapeutic targets. These targets include pathways involved in inflammation, cellular repair and fibrosis, cellular metabolism and mitochondrial function, oxidative stress, apoptosis, and hemodynamics and oxygen delivery. Read More

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http://dx.doi.org/10.1007/s40265-019-01119-8DOI Listing

A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.

Arch Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

Previous epidemiological studies have suggested a link between high-cholesterol intake and liver disease progression, including hepatocellular carcinoma (HCC). However, the precise mechanism of hepatotoxicity and hepatocarcinogenesis caused by excessive cholesterol consumption remains unclear. We aimed to investigate the impact of dietary cholesterol using hepatitis C virus core gene transgenic (HCVcpTg) mice, which spontaneously developed HCC with age. Read More

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http://dx.doi.org/10.1007/s00204-019-02440-7DOI Listing
April 2019
5.980 Impact Factor

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Charité Center 11, Charité-University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany.

Aims: Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and PAR2 have not been studied in HFpEF, age-dependent cardiac fibrosis, or diastolic dysfunction (DD). Read More

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz117DOI Listing
April 2019
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The role of sphingosine kinase 2 in alcoholic liver disease.

Dig Liver Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology and Immunology, Medical College of Virginia and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address:

Alcoholic liver disease (ALD) is one of the most common liver diseases worldwide. However, the exact mechanisms underlying ALD remain unclear. Previous studies reported that sphingosine kinase 2 (SphK2) plays an essential role in regulating hepatic lipid metabolism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193052
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http://dx.doi.org/10.1016/j.dld.2019.03.020DOI Listing
April 2019
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Addressing lung transplant with adults with cystic fibrosis: A qualitative analysis of patients' perspectives and experiences.

J Cyst Fibros 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA, USA.

Referral for lung transplantation is a complex process that typically begins with a discussion in cystic fibrosis (CF) clinic. We performed a secondary analysis of interviews conducted at the University of Washington CF Clinic as part of a study of unmet palliative care needs, June 2015 - January 2016, among adults with moderate-to-severe CF-related lung disease. Content analysis methods were used to identify themes related to discussion of lung transplant in CF clinic. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.007DOI Listing

Characteristics and association with survival of respiratory-related hospitalization in Japanese idiopathic pulmonary fibrosis patients.

Respir Investig 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Osakasayama, Osaka, Japan. Electronic address:

Background: The characteristics and significance of respiratory-related hospitalization in patients with idiopathic pulmonary fibrosis (IPF) in Asian countries remain unknown. The purpose of this study was to define the characteristics of respiratory-related hospitalization and to inspect the relationship between respiratory-related hospitalization and subsequent survival in patients with IPF in Japanese general practice.

Methods: Patients with IPF who underwent clinical evaluation between February 2008 and August 2017 were screened. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183031
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http://dx.doi.org/10.1016/j.resinv.2019.03.005DOI Listing
April 2019
1 Read

Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia.

Respir Investig 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-higashi, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address:

Background: Some cases of idiopathic fibrotic nonspecific interstitial pneumonia (f-NSIP) show a progressive course that is similar to that of idiopathic pulmonary fibrosis. However, it is difficult to predict poor patient outcomes. This study aimed to evaluate whether serial changes in serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) can predict disease progression. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.03.006DOI Listing

"No-No" Head Tremor-A Nod to the Diagnosis.

Pediatr Neurol 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology and Neurophysiology, Temple Street Children's University Hospital, Dublin, Ireland; Academic Centre on Rare Diseases, School of Medicine and Medical Science, University College Dublin, Ireland.

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https://linkinghub.elsevier.com/retrieve/pii/S08878994193002
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.007DOI Listing
March 2019
1 Read

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. Read More

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http://dx.doi.org/10.3390/nu11040872DOI Listing

Does austerity really kill?

Econ Hum Biol 2019 Mar 4;33:211-223. Epub 2019 Mar 4.

Centre for Health Economics, University of York, York, United Kingdom; Luxembourg Institute for Socio-Economic Research, Esch-sur-Alzette/Belval, Luxembourg.

A growing body of the literature has argued that austerity has been bad for health, though without directly measuring austerity. This paper explicitly distinguishes the association of mortality with macroeconomic fluctuations from that with fiscal policy measures, using data for 28 European Union (EU) countries covering the period 1991-2013. The main results present a nuanced, complex picture about the mortality impact of fiscal policies. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.03.002DOI Listing

Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways.

Pharmacol Rep 2019 Jan 15;71(3):409-416. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: Liver fibrosis is a chronic lesion which ultimately results in cirrhosis and possible death. Although the high incidence and lethality, few therapies are effective for liver fibrosis. Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a natural product extracted from cortex fraxini, has exhibited a significant hepatoprotective and anti-fibrotic properties. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.008DOI Listing
January 2019

Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway.

Exp Gerontol 2019 Apr 16. Epub 2019 Apr 16.

The First Affiliated Hospital of Chongqing Medical University, Friendship Road 1, YuZhong District, Chongqing 400016, China. Electronic address:

Sarcopenia is an age-related syndrome characterized by a gradual loss of muscle mass and function, but its pathophysiological mechanism remains unclear. Skeletal muscle extracellular matrix (ECM) remodeling is an important pathological change in sarcopenia, and fibrosis is the most obvious manifestation of this change. We found that the expression of the immunoreceptor Toll-like receptor 9 (TLR9) is significantly increased in skeletal muscle in aged mice and is positively related to muscle fibrosis. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.008DOI Listing

The wound healing and antibacterial potential of triple-component nanocomposite (chitosan-silver-sericin) films loaded with moxifloxacin.

Int J Pharm 2019 Apr 16;564:22-38. Epub 2019 Apr 16.

Department of Pharmacy, COMSATS University Islamabad, Lahore Campus 54000, Pakistan. Electronic address:

Aim: The current study reports the development and evaluation of chitosan-sericin-silver nanocomposite (CSSN) films without and with moxifloxacin (Mox).

Methodology: The film preparation method involved the in-situ synthesis of silver nanoparticles within the chitosan-sericin colloidal composite followed by preparation into a film by solvent casting technique. In-situ formation and the particle size analysis of the silver nanoparticles was performed via UV-Visible and zeta-size spectrometer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193030
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.046DOI Listing
April 2019
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Response to letter to Editor "Validation study of elastographies in patients with nonalcoholic fatty liver disease for detecting liver fibrosis".

Clin Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193041
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http://dx.doi.org/10.1016/j.cgh.2019.04.027DOI Listing
April 2019
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Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (girls), Al-Azhar University, Cairo, Egypt.

Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain. This study investigated the neuroprotective effect of pregabalin in an experimental model of diabetic retinopathy and tested some possible mechanisms underlying the putative neuroprotective effect. Male Wistar rats received streptozotocin (45 mg/kg) to induce type 1 diabetes mellitus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183023
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http://dx.doi.org/10.1016/j.exer.2019.04.014DOI Listing
April 2019
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Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011385. Epub 2019 Apr 19.

Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT.

Background: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. Read More

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http://doi.wiley.com/10.1002/14651858.CD011385.pub3
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http://dx.doi.org/10.1002/14651858.CD011385.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474399PMC
April 2019
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External Validation of a Pre-Transplant Biomarker Model (REVERSE) Predictive of Renal Recovery after Liver Transplantation.

Hepatology 2019 Apr 19. Epub 2019 Apr 19.

Baylor University Medical Center, Dallas, TX, United States.

In patients with end stage liver disease, the ability to predict recovery of renal function following liver transplantation alone (LTA) remains elusive. However, several important clinical decisions depend on whether renal dysfunction is recoverable after LTA. We used a cohort of patients undergoing LT to independently validate a pre-LT model predictive of post-LTA renal recovery (REVERSE: high osteopontin (OPN) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels, age <57, no diabetes). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30667
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http://dx.doi.org/10.1002/hep.30667DOI Listing
April 2019
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The interplay between microbiota-dependent metabolite trimethylamine N-oxide, Transforming growth factor β/SMAD signaling and inflammasome activation in chronic kidney disease patients: A new mechanistic perspective.

J Cell Biochem 2019 Apr 19. Epub 2019 Apr 19.

Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Chronic kidney disease (CKD) signifies a frequently life-threatening condition influencing kidney structure and function. Despite its irrefutable importance, its exact pathogenesis is not completely clarified. However, CKD is known to be associated with accumulated uremic toxins/metabolites, interstitial fibrosis, and systemic inflammation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28707
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http://dx.doi.org/10.1002/jcb.28707DOI Listing
April 2019
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Investigating the potential benefit of second biopsy of residual mass in pediatric mature B cell non-Hodgkin lymphoma.

Pediatr Hematol Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

a Department of Hematology/Oncology , Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China.

Objectives: To assess the impact of second-look biopsy of residual mass during or after chemotherapy in pediatric mature B-cell NHL.

Methods: Patients with mature B-cell non-Hodgkin lymphoma (NHL) who were suspicious of radiological residual mass at mid or end of treatment and subjected to second biopsy were treated at our center between January 2001 and December 2015. Their clinical characteristics, imaging findings, pathological changes, management, and prognosis were reviewed retrospectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2019.1
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http://dx.doi.org/10.1080/08880018.2019.1597231DOI Listing
April 2019
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NAKα2 inhibits fibrosis formation and protects against cardiomyocyte hypertrophy by suppressing hypertrophy associated molecules and activating LTCC/NCX signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3021-3033

Geriatric Department of The First Hospital Affiliated To AMU, Chongqing, China.

Objective: Cardiomyocyte hypertrophy is considered to be a compensatory process of heart suffering from pathological damages. This study aimed to evaluate effects of Na+/K+ APTaseα2 (NAKα2) on isoprenaline (ISO) induced cardiomyocyte hypertrophy.

Materials And Methods: Mouse atrial cardiomyocytes were cultured and treated with ISO to establish cardiomyocyte hypertrophy model. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17584DOI Listing

[Myocardial Contractile Function in Patients with Liver Cirrhosis and Syndrome of Bacterial Overgrowth Syndrome].

Kardiologiia 2019 Apr 17;59(4):67-73. Epub 2019 Apr 17.

Sechenov First Moscow State Medical University (Sechenov University).

Objective: to study myocardial contractile function in patients with liver cirrhosis and ascites in the presence of bacterial overgrowth syndrome (BOS) and pathological bacterial translocation.

Materials And Methods: We included in this study 59 patients with Child-Pugh class B and C liver cirrhosis (LC) of various etiology and ascites. Control group comprised 12 patients with ischemic heart disease complicated by chronic heart failure (CHF). Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10252DOI Listing
April 2019
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