351,239 results match your criteria Cirrhosis


[News for usage of albumin in patients with liver disease].

Dtsch Med Wochenschr 2020 Jun 3;145(11):722-726. Epub 2020 Jun 3.

Universitätsklinikum Frankfurt am Main - Medizinische Klinik I, Goethe-Universität Frankfurt am Main.

The recommended indications for short-term use of human albumin in patients with decompensated cirrhosis are the following: prevention of paracenteses induced circulatory dysfunction, treatment of hypovolemia, prevention of hepatorenal syndrome in high-risk patients with spontaneous bacterial peritonitis, as well as treatment of hepatorenal syndrome. Liver cirrhosis is associated with systemic inflammation, which is further increased in decompensated cirrhosis and acute-on-chronic liver failure. Besides its function as plasma expander, albumin is known to have pleiotropic non-oncotic properties. Read More

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http://dx.doi.org/10.1055/a-1012-6991DOI Listing

How Much Liver Tissue Is Required for Sufficient Histological Staging in Patients with Primary Biliary Cholangitis?

Digestion 2020 Jun 3:1-9. Epub 2020 Jun 3.

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany,

Introduction: Histological alterations in primary biliary cholangitis (PBC) are heterogeneously distributed throughout the liver. Thus, the quality of histological staging is probably dependent on the available amount of liver tissue. The goals of this study were to test this hypothesis and to define biopsy conditions for obtaining sufficient tissue. Read More

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http://dx.doi.org/10.1159/000507392DOI Listing

Provision of information on transplantation to cystic fibrosis patients and their relatives: Overview of French practices and recommendations.

Respir Med Res 2020 Jan 23;77:79-88. Epub 2020 Jan 23.

Service d'Évaluation Médicale et d'Épidémiologie, CHU de Nantes, Nantes, France; UMR Inserm 1246-Methods in Patient-Centered Outcomes and Health Research (SPHERE), Nantes, France.

Background: How health-care professionals inform cystic fibrosis patients and their relatives about transplantation is not well known. Such information may not be provided in a timely or satisfactory manner. We conducted a survey about patient information practices among professionals from all French cystic fibrosis centers and transplant centers, to determine how they might be improved. Read More

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http://dx.doi.org/10.1016/j.resmer.2019.12.002DOI Listing
January 2020

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.

Cell Rep 2020 Jun;31(9):107721

Program in Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B. cenocepacia can survive inside infected macrophages within the B. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107721DOI Listing

Two hits to the renin-angiotensin system may play a key role in severe COVID-19.

Kaohsiung J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

The spike glycoprotein on the virion surface docking onto the angiotensin-converting enzyme (ACE) 2 dimer is an essential step in the process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in human cells-involves downregulation of ACE2 expression with systemic renin-angiotensin system (RAS) imbalance and promotion of multi-organ damage. In general, the RAS induces vasoconstriction, hypertension, inflammation, fibrosis, and proliferation via the ACE/Ang II/Ang II type 1 receptor (AT1R) axis and induces the opposite effects via the ACE2/Ang (1-7)/Mas axis. The RAS may be activated by chronic inflammation in hypertension, diabetes, obesity, and cancer. Read More

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http://dx.doi.org/10.1002/kjm2.12237DOI Listing

Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.

J Biochem 2020 Jun 3. Epub 2020 Jun 3.

Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, Japan.

A role of 12-lipoxygenase in the progression of nonalcoholic steatohepatitis (NASH) is suggested, although the underlying mechanism is not entirely understood. The catalytic activity of 12S-lipoxygenase which was hardly observed in liver cytosol of normal chow-fed mice was clearly detectable in that of NASH model mice prepared by feeding a methionine and choline-deficient (MCD) diet. The product profile, substrate specificity and immunogenicity indicated that the enzyme was the platelet-type isoform. Read More

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http://dx.doi.org/10.1093/jb/mvaa062DOI Listing

Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.

PLoS One 2020 3;15(6):e0234038. Epub 2020 Jun 3.

Second Genome Inc., South San Francisco, California, United States of America.

Extracellular adenosine triphosphate (eATP) released by damaged cells, and its purinergic receptors, comprise a crucial signaling network after injury. Purinergic receptor P2X7 (P2RX7), a major driver of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and IL-1β processing, has been shown to play a role in liver injury in murine diet- and chemically-induced liver injury models. It is unclear, however, whether P2RX7 plays a role in non-alcoholic steatohepatitis (NASH) and which cell type is the main target of P2RX7 pharmacological inhibition. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234038PLOS

Protein Tyrosine Phosphatase-α Amplifies TGF-β-Dependent Pro-Fibrotic Signaling in Lung Fibroblasts.

Am J Physiol Lung Cell Mol Physiol 2020 Jun 3. Epub 2020 Jun 3.

Academic Affairs, National Jewish Health, United States.

Idiopathic Pulmonary Fibrosis (IPF) is a progressive fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β, are central to its pathogenesis. Protein Tyrosine Phosphatase-alpha (PTPα) has emerged as a key regulator of fibrogenic signaling in fibroblasts. Read More

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http://dx.doi.org/10.1152/ajplung.00235.2019DOI Listing

Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis.

Physiol Int 2020 Mar;107(1):67-81

2Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Betanin is a betacyanin with antioxidant and anti-inflammatory activities whose effects were investigated in a nonalcoholic steatohepatitis (NASH) model.

Main Methods: Ninety-six male naval medical research institute (NMRI) mice were divided into eight groups (n = 12) including normal control, high fat diet (HFD), Sham, and positive control treated with trans-chalcone. Three experimental groups were treated with 5 mg/kg, 10 mg/kg or 20 mg/kg betanin, and a betanin protective group was also defined. Read More

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http://dx.doi.org/10.1556/2060.2020.00001DOI Listing

Identifying an Optimal Liver Frailty Index Cutoff to Predict Waitlist Mortality in Liver Transplant Candidates.

Hepatology 2020 Jun 3. Epub 2020 Jun 3.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California-San Francisco, San Francisco, California, United States.

Background&aims: Frailty, as measured by the liver frailty index (LFI), is associated with liver transplant (LT) waitlist mortality. We sought to identify an optimal LFI cutoff that predicts waitlist mortality.

Approach&results: Adults with cirrhosis awaiting LT without hepatocellular carcinoma at 9 LT centers in the United States with LFI assessments were included. Read More

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http://dx.doi.org/10.1002/hep.31406DOI Listing

Reliability of acoustic radiation force impulse shear wave elastography in the evaluation of liver stiffness in morbidly obese patients.

J Clin Ultrasound 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose: To evaluate technical and patient-related factors that can affect the reliability of acoustic radiation force impulse shear wave elastography (ARFI-SWE) in morbidly obese patients.

Methods: A prospective single-center study was performed on 41 patients (32 females, 78%) presenting for preoperative evaluation for bariatric surgery. ARFI-SWE was performed using a 6 to 1. Read More

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http://dx.doi.org/10.1002/jcu.22837DOI Listing

PANCREATIC STEATOSIS: A NEW DIAGNOSIS AND THERAPEUTIC CHALLENGE IN GASTROENTEROLOGY.

Arq Gastroenterol 2020 May 20. Epub 2020 May 20.

Department of Gastroenterology, University Hospital of North Cumbria, UK.

Fat infiltration in the pancreas is called pancreatic steatosis and it has several synonyms such as pancreatic lipomatosis, non-alcoholic fatty pancreatic disease, lipomatous pseudohypertrophy, fatty replacement, fatty pancreas and fatty infiltration. Pancreatic steatosis describes a disease ranging from infiltration of fat in the pancreas to pancreatic inflammation, and development of pancreatic fibrosis. There are multiple aetiologies of this condition, such as metabolic syndrome, alcohol intake, viral infections, toxins, congenital syndromes, etc. Read More

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http://dx.doi.org/10.1590/s0004-2803.202000000-27DOI Listing

Sodium-Glucose Cotransporter-2(SGLT2-I) inhibitor are not the magic pills for control of ascites in cirrhosis and diabetes.

Hepatology 2020 Jun 3. Epub 2020 Jun 3.

Asian Institute of Gastroenterology, Hyderabad, India.

We read with great interest the case series by Gordon et al. It is indeed very interesting to know that sodium-glucose cotransporter-2 inhibitors (SGLT2-I) can improve ascites control and pedal edema along with achieving adequate glycemic control in patients with cirrhosis and type 2 diabetes mellitus(T2DM) (1). But there are certain concerns which we would like highlight. Read More

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http://dx.doi.org/10.1002/hep.31399DOI Listing

Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.

Clin Sci (Lond) 2020 Jun 3. Epub 2020 Jun 3.

Dept. of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical Univ., 72 Guangzhou Road, Nanjing 210029, Jiangsu Province, China.

Non-specific inhibition of Rho-associated kinases (ROCKs) alleviated renal fibrosis in the unilateral ureteral obstruction (UUO) model, while genetic deletion of ROCK1 did not affect renal pathology in mice. Thus, whether ROCK2 plays a role in renal tubulointerstitial fibrosis needs to be clarified. In this study, a selective inhibitor against ROCK2 or genetic approach was used to investigate the role of ROCK2 in renal tubulointerstitial fibrosis. Read More

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http://dx.doi.org/10.1042/CS20200030DOI Listing

USPIO-PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis.

J Mater Chem B 2020 Jun 3. Epub 2020 Jun 3.

Sorbonne Université, CNRS, Laboratoire de la Chimie de la Matière Condensée (LCMCP), Paris, F-75005, France.

Fibrosis is characterized by a pathologic deposition of collagen I, leading to impaired function of organs. Tissue biopsy is the gold standard method for the diagnosis of fibrosis but this is an invasive procedure, subject to sampling errors. Several non-invasive techniques such as magnetic resonance imaging (MRI) using non-specific probes have been developed but they are not fully satisfying as they allow diagnosis at a late stage. Read More

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http://dx.doi.org/10.1039/d0tb00887gDOI Listing

Evolving thresholds for liver transplantation in hepatocellular carcinoma: A Western experience.

Ann Gastroenterol Surg 2020 May 11;4(3):208-215. Epub 2020 Feb 11.

Division of Surgical Oncology Department of Surgery University of Texas Southwestern Medical Center Dallas Texas.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Once considered an experimental treatment with dismal survival rates, liver transplantation for HCC entered a new era with the establishment of the Milan criteria over 20 years ago. In the modern post-Milan-criteria era, 5-year survival outcomes are now upwards of 70% in select patients. Read More

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http://dx.doi.org/10.1002/ags3.12316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240148PMC

Nonalcoholic Fatty Liver Disease and Alcoholic Liver Disease are Major Drivers of Liver Mortality in the United States.

Hepatol Commun 2020 Jun 4;4(6):890-903. Epub 2020 Apr 4.

Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.

In the United States, chronic viral hepatitis B and C (CHB and CHC), nonalcoholic fatty liver disease (NAFLD), and alcohol-related liver disease (ALD) are the main causes of liver deaths attributable to hepatocellular carcinoma (HCC) and cirrhosis. Our aim was to assess the changes in the rates of mortality and years of potential life lost (YLL) for HCC and cirrhosis due to different liver diseases. We used multiple-cause mortality data (2007-2017) from the National Center for Health Statistics. Read More

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http://dx.doi.org/10.1002/hep4.1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262283PMC

Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans.

Hepatol Commun 2020 Jun 21;4(6):859-875. Epub 2020 Apr 21.

Department of Pathology University of Pittsburgh Pittsburgh PA.

Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α-based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients with advanced cirrhosis, HNF4α RNA expression levels decrease as hepatic function deteriorates, and protein expression is found in the cytoplasm. These findings could explain impaired hepatic function in patients with degenerative liver disease. Read More

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http://dx.doi.org/10.1002/hep4.1505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262291PMC

Comprehensive Health-State Utilities in Contemporary Patients With Cirrhosis.

Hepatol Commun 2020 Jun 2;4(6):852-858. Epub 2020 Apr 2.

Division of Gastroenterology and Hepatology University of Michigan Ann Arbor MI.

Cost-effectiveness analysis depends on generalizable health-state utilities. Unfortunately, the available utilities for cirrhosis are dated, may not reflect contemporary patients, and do not capture the impact of cirrhosis symptoms. We aimed to determine health-state utilities for cirrhosis, using both the standard gamble (SG) and visual analog scale (VAS). Read More

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http://dx.doi.org/10.1002/hep4.1512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262287PMC

Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.

Hepatol Commun 2020 Jun 16;4(6):834-851. Epub 2020 Apr 16.

Department of Internal Medicine III University Hospital RWTH Aachen Aachen Germany.

Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO) mice, focusing on liver damage, cell death, compensatory proliferation, fibrogenesis, and tumor development. Read More

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http://dx.doi.org/10.1002/hep4.1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262317PMC

A Telephone and Mail Outreach Program Successfully Increases Uptake of Hepatocellular Carcinoma Surveillance.

Hepatol Commun 2020 Jun 24;4(6):825-833. Epub 2020 Apr 24.

Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine University of California Los Angeles Los Angeles CA.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Society guidelines recommend surveillance with abdominal ultrasound with or without serum alpha-fetoprotein every 6 months for adults at increased risk of developing HCC. However, adherence is often suboptimal. Read More

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http://dx.doi.org/10.1002/hep4.1511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262281PMC

Allele-Specific Prevention of Nonsense-Mediated Decay in Cystic Fibrosis Using Homology-Independent Genome Editing.

Mol Ther Methods Clin Dev 2020 Jun 12;17:1118-1128. Epub 2020 May 12.

Program in Genetics and Genome Biology, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.

Nonsense-mediated decay (NMD) is a major pathogenic mechanism underlying a diversity of genetic disorders. Nonsense variants tend to lead to more severe disease phenotypes and are often difficult targets for small molecule therapeutic development as a result of insufficient protein production. The treatment of cystic fibrosis (CF), an autosomal recessive disease caused by mutations in the gene, exemplifies the challenge of therapeutically addressing nonsense mutations in human disease. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256445PMC

Assessment of myocardial extracellular volume on body computed tomography in breast cancer patients treated with anthracyclines.

Quant Imaging Med Surg 2020 May;10(5):934-944

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milan, Italy.

Background: Cancer treatment with anthracyclines may lead to an increased incidence of cardiac disease due to cardiotoxicity, as they may cause irreversible myocardial fibrosis. So far, the proposed methods for screening patients for cardiotoxicity have led to only limited success, while the analysis of myocardial extracellular volume (mECV) at cardiac magnetic resonance (CMR) has shown promising results, albeit requiring a dedicated exam. Recent studies have found strong correlations between mECV values obtained through computed tomography (CT), and those derived from CMR. Read More

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http://dx.doi.org/10.21037/qims.2020.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242290PMC

Ceftolozane/tazobactam for pulmonary exacerbation in a 63-year-old cystic fibrosis patient with renal insufficiency and an elevated MIC to .

IDCases 2020 18;21:e00830. Epub 2020 May 18.

Adult Cystic Fibrosis Center, Pensacola Lung Group, Pensacola, FL, United States.

Cystic fibrosis (CF) is a progressive genetic disorder caused by mutations in a gene encoding the cystic fibrosis transmembrane regulator (CFTR) protein leading to persistent and difficult to treat lower airway infections. Multi-drug resistant is becoming increasingly more common as a cause of pulmonary exacerbations, and newer agents such as ceftolozane/tazobactam (C/T) are being sought for treatment. There is currently little published data regarding its use in cystic fibrosis, particularly in the setting of reduced renal clearance. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256659PMC

Assessment of Eustachian tube functioning following surgical intervention of Oral Submucus Fibrosis by using tympanometry & audiometry.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):241-245. Epub 2019 Nov 27.

Department of Speech Audiology, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal, India.

Oral Submucus fibrosis has been reported to cause variation in hearing sensitivity & changes in middle ear function. This study was conducted to validate the influence of OSMF and its surgical correction on middle ear function and hearing sensitivity. In this study, 20 patients (40 ears) suffering from biopsy proven OSMF (Group 2 & 3) were tested for Middle ear dysfunction and hearing sensitivity using Tympanometry & Audiometry. Read More

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http://dx.doi.org/10.1016/j.jobcr.2019.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254461PMC
November 2019

Expression of transforming growth factor beta in oral submucous fibrosis.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):166-170. Epub 2020 Apr 13.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Background: Oral submucous fibrosis (OSMF) is a premalignant condition mainly caused by areca nut chewing and is characterized by progressive fibrosis of submucosal tissues and epithelial atrophy. Activation of transforming growth factor beta (TGF-β) signaling is considered main causative event for increased collagen production and fibrosis. In this study, molecular pathogenesis of OSMF was investigated based on the expression of the TGF-β genes in OSMF tissues compared to normal controls. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254463PMC

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective.

Glob Heart 2020 Feb 12;15(1):15. Epub 2020 Feb 12.

Department of Medicine, Harvard Medical School, Boston, US.

Non-communicable diseases (NCDs) are the second common cause of death in sub-Saharan Africa (SSA) accounting for about 35% of all deaths, after a composite of communicable, maternal, neonatal, and nutritional diseases. Despite prior perception of low NCDs mortality rates, current evidence suggests that SSA is now at the dawn of the epidemiological transition with contemporary double burden of disease from NCDs and communicable diseases. In SSA, cardiovascular diseases (CVDs) are the most frequent causes of NCDs deaths, responsible for approximately 13% of all deaths and 37% of all NCDs deaths. Read More

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http://dx.doi.org/10.5334/gh.403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218780PMC
February 2020

Effect of Shakuyaku-kanzo-to in patients with muscle cramps: A systematic literature review.

J Gen Fam Med 2020 May 16;21(3):56-62. Epub 2020 Feb 16.

Department of Emergency Medicine Osaka Medical College Takatsuki Japan.

Background: Previous clinical studies have reported that Shakuyaku-kanzo-to (SKT) has a therapeutic effect on muscle cramps, but few studies have clarified how SKT acts to treat muscle cramps. The aim of this study was to perform an updated systematic review of clinical trials for SKT in patients with muscle cramps.

Methods: The literature was systematically reviewed to assess the effects of SKT in patients with muscle cramps. Read More

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http://dx.doi.org/10.1002/jgf2.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260166PMC

Managing Acute Portal Hypertensive Gastropathy Bleed During the Time of COVID-19 Pandemic: Novelty or Necessity?

Cureus 2020 May 28;12(5):e8333. Epub 2020 May 28.

Gastroenterology, Cochin Gastroenterology Group, Kochi, IND.

Acute bleeding from portal hypertensive gastropathy (PHG) is an extremely rare event in the natural history of cirrhosis. The treatment recommendations include portal pressure reduction strategies including pharmacotherapy with vasoactive agents and beta-blockers and interventional strategies such as transjugular intrahepatic portosystemic shunt placement. In this report, we present the case of a patient with cirrhosis in whom acute PHG-related bleed was managed with endoscopic band ligation, a therapeutic modality which has not been described in current literature. Read More

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http://dx.doi.org/10.7759/cureus.8333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255538PMC

Hemorrhagic Cholecystitis in a Patient with Cirrhosis and Rectal Cancer.

Cureus 2020 Apr 29;12(4):e7882. Epub 2020 Apr 29.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Hemorrhagic cholecystitis is a rare presentation of acute calculous cholecystitis which presents with abdominal pain, jaundice, and gastrointestinal bleeding. It is a challenging diagnosis to make because it present similar to other common disorders such as calculous cholecystitis. We present a unique case of hemorrhagic cholecystitis in a patient with cirrhosis and rectal cancer. Read More

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http://dx.doi.org/10.7759/cureus.7882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255552PMC

Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice.

Aging Dis 2020 May 9;11(3):588-602. Epub 2020 May 9.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control. We investigated the renoprotective effects of DPP-4 inhibitors on aging mice mediated by the renin-angiotensin system (RAS). C57BL/6 mice were divided into three groups: the two-month-old mice (YM group), the eighteen-month-old mice (AM group) and the eighteen-month-old, linagliptin-treated mice (AM + LIN group). Read More

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http://dx.doi.org/10.14336/AD.2019.0620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220286PMC

Incorporation of frailty estimated by gait speed within MELD-Na and the predictive potential for mortality in cirrhosis.

Ther Adv Chronic Dis 2020 18;11:2040622320922023. Epub 2020 May 18.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China.

Background: The 5 m gait speed (5MGS), a simple and reliable performance metric and surrogate indicator of frailty, consistently predicts adverse events in elders. Additionally, MELD-Na (model for end-stage liver disease-sodium) scores fail to capture nutritional and functional decline of cirrhotic patients that may confer excess mortality. We hypothesized that 5MGS might be associated with all-cause mortality, and that inclusion of frailty assessment within MELD-Na could improve the prediction of mortality in cirrhosis. Read More

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http://dx.doi.org/10.1177/2040622320922023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238306PMC

Biochemical and computational study of an alginate lyase produced by strain S21.

Iran J Basic Med Sci 2020 Apr;23(4):454-460

Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.

Objectives: Alginates play a key role in mucoid colonization, biofilm formation, and driving out of cationic antibiotics. alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Read More

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http://dx.doi.org/10.22038/ijbms.2020.37277.8874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239423PMC

Rationale and protocol design for the TORG1835/NEXT-SHIP study: a phase II study of carboplatin, etoposide and nintedanib for unresectable limited/extensive disease small cell lung cancer with idiopathic pulmonary fibrosis.

Ther Adv Med Oncol 2020 18;12:1758835920923431. Epub 2020 May 18.

Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.

Background: Interstitial pneumonia (IP) is one of the most common and poor prognostic comorbidities in patients with small cell lung cancer (SCLC). The pharmacotherapy for SCLC occasionally induces fatal acute exacerbation of comorbid IP, especially in patients with idiopathic pulmonary fibrosis (IPF). Safe and effective pharmacotherapy is of greater importance in patients with SCLC and IPF, because SCLC presents a poor prognosis without systemic treatment. Read More

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http://dx.doi.org/10.1177/1758835920923431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238300PMC

Cisplatin-induced renal toxicity in elderly people.

Ther Adv Med Oncol 2020 18;12:1758835920923430. Epub 2020 May 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Despite available prevention and treatment measures, such as hydration, diuresis, magnesium supplementation, and amifostine, renal toxicity is still one of the major dose-limiting side effects of cisplatin. The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Read More

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http://dx.doi.org/10.1177/1758835920923430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238313PMC

[Recent advances in treatment of viral pneumonia using Chinese patent medicine].

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(7):1509-1514

Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.

Viral pneumonia is caused by a spreading of lung infection caused by respiratory viruses. Some virus infections were found to be highly aggressive, leading to lung inflammation and severe damage in respiratory system with high fatality rate. Currently, there is no effective therapeutic drugs in the clinic. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200312.502DOI Listing

[Discovery of intervention effect of Chinese herbal formulas on COVID-19 pulmonary fibrosis treated by VEGFR and FGFR inhibitors].

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(7):1481-1487

State Administration of Traditional Chinese Medicine, Research Center of Traditional Chinese Medicine-Information Engineering,Key Technology of Traditional Chinese Medicine Pharmacy and New Drug Development Engineering Research Center of Ministry of Education, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.

Since February 2020, a large number of patients infected with new coronavirus has been cured and discharged with the controlling of epidemic. Pulmonary fibrosis, which may be one of the sequela caused by COVID-19, not only brings dyspnea and deterioration of lung function, but also affects patients' life because of its high mortality and poor prognosis. Vascular endothelial growth factor receptor(VEGFR) and fibroblast growth factor receptor(FGFR) can inhibit the proliferation, activation and migration of fibroblasts by regulating the signal transduction pathway involved in the process of pulmonary fibrosis. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200315.401DOI Listing

Antifibrotics Effect of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide in Mice with BCG-Induced Granulomatosis Depends on Administration Route.

Bull Exp Biol Med 2020 Jun 2. Epub 2020 Jun 2.

Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

We studied the response of the extracellular matrix of the lungs and liver in mice with BCGinduced granulomatosis (3 months) after inhalation and intraperitoneal administration of liposome-encapsulated dextrazide (LEDZ): a conjugate of oxidized dextran (40 kDa) and isonicotinic acid hydrazide (INH). LEDZ inhalation proved to be more effective in reducing fibrosis severity, both in the lungs and liver. However, the mechanisms of the antifibrotic effect were different: increased degradation and reduced collagen synthesis in the lungs and reduced collagen synthesis and collagen degradation in the liver. Read More

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http://dx.doi.org/10.1007/s10517-020-04827-4DOI Listing

Protective effects of cardiac resynchronization therapy in a canine model with experimental heart failure by improving mitochondrial function: a mitochondrial proteomics study.

J Interv Card Electrophysiol 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Purpose: Cardiac resynchronization therapy (CRT) is well acknowledged as an effective treatment for dyssynchronous heart failure. However, the molecular mechanism is unclear to date. Mitochondrial dysfunction and impaired energetic metabolism are two important mechanisms that lead to heart failure. Read More

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http://dx.doi.org/10.1007/s10840-020-00768-0DOI Listing

Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination.

Gastric Cancer 2020 Jun 2. Epub 2020 Jun 2.

Division of Cancer Medicine, Department of Gastroenterological Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objectives: Interleukin-17A (IL-17A) is pro-inflammatory cytokine and acts as profibrotic factor in the fibrosis of various organs. Fibrosis tumor-like peritoneal dissemination of gastric cancer interferes with drug delivery and immune cell infiltration because of its high internal pressure. In this study, we examined the relationship between IL-17A and tissue fibrosis in peritoneal dissemination and elucidated the mechanism of fibrosis induced by IL-17A using human peritoneal mesothelial cells (HPMCs) and a mouse xenograft model. Read More

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http://dx.doi.org/10.1007/s10120-020-01092-2DOI Listing

Laparoscopic Central Bisectionectomy Including Resection of the Segment 7 Using the Extrahepatic Glissonean Approach and Hepatic Vein Guidance.

Ann Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, Police General Hospital, Bangkok, Thailand.

Background: Certain variations in liver anatomy can aid in parenchymal-preserving hepatectomy.1,2 Inferior right hepatic vein (IRHV) is an accessory vein in the right side of liver draining segment 6.2 We present a case of 67-year-old man with HBV cirrhosis. Read More

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http://dx.doi.org/10.1245/s10434-020-08668-3DOI Listing