371,576 results match your criteria Cirrhosis


Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.

Eur J Radiol 2021 May 1;140:109748. Epub 2021 May 1.

Department of Cardiovascular Sciences, University of Leicester and Cardiovascular Theme, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.

Purpose: Myocardial native T1 is a potential measure of myocardial fibrosis, but concerns remain over the potential influence of myocardial edema to increased native T1 signal in subjects prone to fluid overload. This study describes differences in native T2 (typically raised in states of myocardial edema) and native T1 times in patients on hemodialysis by comparing native T1 and native T2 times between subjects on hemodialysis to an asymptomatic control group. Reproducibility of these sequences was tested. Read More

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(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.

Bioorg Chem 2021 Apr 26;112:104950. Epub 2021 Apr 26.

School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China; Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, People's Republic of China. Electronic address:

Five pairs of meroterpenoid enantiomers, (±)-gancochlearols J - N (1-5), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated on the basis of 1D and 2D NMR and HRESIMS data. The absolute configurations of gancochlearols J - M (1-4) were assigned by electronic circular dichroism (ECD) calculations. Read More

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Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of c-Jun N-terminal kinases: Short title: Sestrins ameliorate hepatic lipotoxicity.

Cell Mol Gastroenterol Hepatol 2021 May 4. Epub 2021 May 4.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background & Aims: Sestrin 1/2/3 (Sesn1/2/3) belong to a small family of proteins that have been implicated in the regulation of metabolic homeostasis and oxidative stress. However, the underlying mechanisms remain incompletely understood. The aim of this work was to illustrate the collective function of Sesn1/2/3 in the protection against hepatic lipotoxicity. Read More

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Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy.

Ann Hepatol 2021 May 4:100358. Epub 2021 May 4.

Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile; ANID, Millennium Science Initiative Program, Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile; Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction And Objectives: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver abnormalities including steatosis, steatohepatitis, fibrosis, and cirrhosis. Liver biopsy remains the gold standard method to determine the disease stage in NAFLD but is an invasive and risky procedure. Studies have previously reported that changes in intrahepatic fatty acids (FA) composition are related to the progression of NAFLD, mainly in its early stages. Read More

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CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis.

Toxicol Lett 2021 May 4. Epub 2021 May 4.

School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China. Electronic address:

For smoking-induced pulmonary fibrosis (PF), a serious disease endangering human health, there is no effective clinical treatment. Aberrant epithelium-fibroblast cross-talk is involved in formation of the excessive extracellular matrix (ECM) that contributes to PF. Circular RNAs have been associated with various pulmonary diseases. Read More

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The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways.

Toxicol Lett 2021 May 4. Epub 2021 May 4.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Liver fibrosis is the conjoint consequence of almost all chronic liver diseases. Cholestatic liver injury is a significant stimulus for fibrotic liver. This study was conducted to investigate the hepatoprotective effect of niclosamide as a NOTCH inhibitor and on the Wnt pathway against cholestatic liver fibrosis (CLF) which was experimentally induced by bile duct ligation (BDL). Read More

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A radiomic approach to predict myocardial fibrosis on coronary CT angiography in hypertrophic cardiomyopathy.

Int J Cardiol 2021 May 4. Epub 2021 May 4.

Department of Radiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 197 Ruijin 2nd Rd, Shanghai 200025, China. Electronic address:

Background: Late gadolinium enhancement (LGE) derived from cardiac magnetic resonance (CMR) represents myocardial fibrosis (MF) and is associated with prognosis in hypertrophic cardiomyopathy (HCM). However, it cannot be evaluated when CMR is unavailable. Hence, we aimed to investigate the ability of radiomic features derived from coronary computed tomography angiography (CCTA) to detect the presence and extent of MF in HCM, with LGE as references. Read More

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SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation.

Toxicol Appl Pharmacol 2021 May 4:115559. Epub 2021 May 4.

Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address:

The occurrence and development of silicosis is related to the interaction of multiple cells through signal transmission caused by silica dust. Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts. As a communication medium between cells, exosomes have become a hot research topic. Read More

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UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.

Biochem Pharmacol 2021 May 4:114592. Epub 2021 May 4.

Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:

UGT1A1 is the only enzyme that can metabolize bilirubin, and its encoding gene is frequently mutated. UGT1A1*6 (G71R) is a common mutant in Asia which leads to the decrease of UGT1A1 activity and abnormal bilirubin metabolism. However, it is not clear whether low UGT1A1 activity-induced bilirubin metabolism disorder increases hepatocyte fragility. Read More

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Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach.

Lancet Gastroenterol Hepatol 2021 May 4. Epub 2021 May 4.

Department of Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.

Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This narrative Review provides an overview of the current literature to support the notion that NAFLD is a multisystem disease. Convincing evidence shows a strong association between NAFLD and the risk of developing multiple extrahepatic complications such as type 2 diabetes, cardiovascular disease (ie, the predominant cause of mortality in people with NAFLD), chronic kidney disease, and some types of extrahepatic malignancies. Read More

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Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C.

PLoS One 2021 7;16(5):e0251392. Epub 2021 May 7.

Helsinki University Hospital, Helsinki, Finland.

Chronic kidney disease (CKD) is one of the most well-known extrahepatic manifestations caused by hepatitis C infection (HCV). CKD is typically discovered at a late stage. HCV-nephropathy may show different histopathologic patterns, as both glomerular and tubulointerstitial damage have been described. Read More

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Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study.

PLoS One 2021 7;16(5):e0250531. Epub 2021 May 7.

Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Read More

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Increased risk of Alzheimer's disease among patients with age-related macular degeneration: A nationwide population-based study.

PLoS One 2021 7;16(5):e0250440. Epub 2021 May 7.

School of Chinese Medicine, China Medical University, Taichung, Taiwan.

Objective: This study aimed to investigate the risk of Alzheimer's disease among patients with age-related macular degeneration and its association with confounding comorbidities.

Method: This was a population-based, retrospective cohort study. By accessing data from the National Health Insurance Research Database of Taiwan, we identified 10,578 patients aged 50-100 years who were newly diagnosed with age-related macular degeneration between 2000 and 2012 and 10,578 non- age-related macular degeneration individuals. Read More

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Propranolol-induced hallucinations mimicking encephalopathy in a patient with liver cirrhosis.

Scand J Gastroenterol 2021 May 7:1-3. Epub 2021 May 7.

Department of Medicine, gastroenterology and hepatology unit, Sahlgrenska University Hospital, Gothenburg, Sweden.

Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis, which is mostly characterized by psychomotor slowing. However, psychotic symptoms such as visual and olfactory hallucinations may sometimes also be present. In contrast, auditory hallucinations are uncommon in chronic liver disease. Read More

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Keloid tissue analysis discredits a role for myofibroblasts in disease pathogenesis.

Wound Repair Regen 2021 May 7. Epub 2021 May 7.

Centre for Inflammation Biology & Cancer Immunology, Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London, London, UK.

Myofibroblasts, renowned for their contractility and extracellular matrix production, are widely considered the key effector cells for nearly all scars resulting from tissue repair processes, ranging from normal scars to extreme fibrosis. For example, it is often assumed that myofibroblasts underpin the characteristics of keloid scars, which are debilitating pathological skin scars lacking effective treatments because of a poor understanding of the disease mechanisms. Here, we present primary and published transcriptional and histological evidence that myofibroblasts are not consistently present in primary keloid lesions, and when alpha-smooth muscle actin (αSMA)-positive cells are detected, they are not greater in number or expressing more αSMA than in normal or hypertrophic scars. Read More

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The Emerging Role of B Cells in the Pathogenesis of NAFLD.

Hepatology 2021 May 7. Epub 2021 May 7.

Department of Integrative Biology & Physiology, University of Minnesota, United States.

Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of abnormal liver function worldwide. NAFLD refers to a group of liver conditions ranging from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), which involves inflammation, hepatocellular damage, and fibrosis. Triggering of inflammation in NASH is a key event in the progression of the disease and identifying the factors that initiate or dysregulate this process is needed to develop strategies for its prevention or treatment. Read More

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Current and past infections of hepatitis B virus do not increase mortality in patients with COVID-19.

Hepatology 2021 May 7. Epub 2021 May 7.

Department of Medicine and Therapeutics, Hong Kong SAR, China.

Background & Aims: We compared risk of acute liver injury and mortality in COVID-19 patients with current, past, and no hepatitis B virus (HBV) infection.

Approach & Results: This was a territory-wide retrospective cohort study in Hong Kong. COVID-19 patients between 23 January 2020 and 1 January 2021 were identified. Read More

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Host Trait Prediction from High-Resolution Microbial Features.

Authors:
Giovanni Bacci

Methods Mol Biol 2021 ;2242:185-202

Department of Biology, University of Florence, Sesto Fiorentino, Italy.

Predicting host traits from metagenomes presents new challenges that can be difficult to overcome for researchers without a strong background in bioinformatics and/or statistics. Profiling bacterial communities using shotgun metagenomics often leads to the generation of a large amount of data that cannot be used directly for training a model. In this chapter we provide a detailed description of how to build a working machine learning model based on taxonomic and functional features of bacterial communities inhabiting the lungs of cystic fibrosis patients. Read More

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January 2021

Coexistent Alcohol-Related Liver Disease and Alcohol-Related Pancreatitis: Analysis of a Large Heath Care System Cohort.

Dig Dis Sci 2021 May 7. Epub 2021 May 7.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: Although coexistence of alcohol-related liver disease (ALD) and pancreatitis (ALP) is seen in clinical practice, a clear understanding of the overlap between these diseases is lacking. Moreover, the relative risks for certain population groups have not been studied. We determined the prevalence and coexistence of ALD and ALP in patients with an alcohol use disorder using retrospective analysis of a large patient cohort from Western Pennsylvania. Read More

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Real-World Data from Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?

Turk J Gastroenterol 2021 Feb;32(2):155-163

Department of Infectious Diseases and Clinical Microbiology, Kütahya Health Sciences University Faculty of Medicine, Kütahya, Turkey.

Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice.

Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Read More

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February 2021

Preoperative Alpha-Fetoprotein Has No Prognostic Role in Small Hepatocellular Carcinoma in Non-Cirrhotic Patients After Surgical Resection.

Turk J Gastroenterol 2021 Feb;32(2):133-140

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, China.

Background: Alpha-fetoprotein (AFP) has been widely used as a tumor marker in the treatment of hepatocellular carcinoma (HCC) in patients with cirrhosis. However, a large number of HCC patients are diagnosed without cirrhosis, and the prognostic capability of AFP was unclear in HCC patients without cirrhosis. Our purpose was to investigate the prognostic efficiency of AFP in patients with non-cirrhosis, single, and small HCC who were treated with surgical resection. Read More

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February 2021

AI in colonoscopy and beyond: On the cusp of clinical implementation?

United European Gastroenterol J 2021 May 7. Epub 2021 May 7.

Liver Transplantation Unit, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

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Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan.

J Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Department of Gastroenterology, Kanazawa University Hospital.

Objective: This study aimed to reveal the timing of bleeding and thromboembolism associated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC).

Methods: We retrospectively reviewed 10,320 patients who underwent ESD for EGC during November 2013-October 2016. We evaluated overall bleeding rates and their inter-group differences. Read More

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Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice.

J Neurosci Res 2021 May 7. Epub 2021 May 7.

Normandie Univ, UNIROUEN, EA3830-GRHV, Rouen, France.

Spinal cord injury (SCI) is a debilitating condition, which leads to a permanent loss of functions below the injury site. The events which take place after SCI are characterized by cellular death, release of inhibitory factors, and inflammation. Many therapies have been studied to cure SCI, among them magnetic stimulation aims to reduce the secondary damages in particular by decreasing apoptosis, while, cellular transplantation promotes neuroregeneration by enhancing axonal regrowth. Read More

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Sudden death due to cardiac contusion: Forensic implications in a rare pediatric case.

J Forensic Sci 2021 May 7. Epub 2021 May 7.

Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni, Università degli Studi di Milano, Milano, Italy.

Blunt chest trauma (BCT) often results in blunt cardiac injuries of little clinical concern, but cases of severe heart damage with high mortality rates have also been described. In particular, BCT should never be underestimated, especially when it is located in the anterior thoracic region. Among traffic accidents, motorcyclists are the most vulnerable and at the greatest risk. Read More

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Molecular genetics of renal ciliopathies.

Biochem Soc Trans 2021 May 7. Epub 2021 May 7.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Central Parkway, Newcastle Upon Tyne NE1 3BZ, U.K.

Renal ciliopathies are a heterogenous group of inherited disorders leading to an array of phenotypes that include cystic kidney disease and renal interstitial fibrosis leading to progressive chronic kidney disease and end-stage kidney disease. The renal tubules are lined with epithelial cells that possess primary cilia that project into the lumen and act as sensory and signalling organelles. Mutations in genes encoding ciliary proteins involved in the structure and function of primary cilia cause ciliopathy syndromes and affect many organ systems including the kidney. Read More

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Unmet needs in the treatment of hypertrophic cardiomyopathy.

Future Cardiol 2021 May 7. Epub 2021 May 7.

Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.

Hypertrophic cardiomyopathy (HCM) is a complex heterogeneous cardiovascular disorder characterized by hypertrophied and disorganized myocytes with varying degrees of interstitial fibrosis. The current management strategies include genetic and familial screening, symptom control and prevention of sudden cardiac death in those at high risk. Until recently, septal reduction therapy and heart transplantation were the only disease modifying treatments available to manage HCM, but emerging pharmacotherapies show promising results in controlled clinical trials. Read More

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Physician Palliative Education Associated With High Use of Hospice Care Service.

Am J Hosp Palliat Care 2021 May 7:10499091211014160. Epub 2021 May 7.

Superintendent Office & Division of Neurosurgery, Department of Surgery, 38010Taipei City Hospital, Taipei.

Background: Taiwan's National Health Insurance provides coverage for palliative and hospice care. The following 10 types of diseases have been added to the National Health Insurance reimbursement regulation: end-stage cancer, motor neuron disease, organic psychosis, brain degeneration, heart failure, chronic airway obstruction diseases, other lung diseases, chronic liver disease and cirrhosis, acute renal failure, and chronic renal failure.

Objective: This study aimed to determine the association between physicians' palliative education and use of hospice care in hospitalized patients at the end of life. Read More

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Physiotherapist involvement in the pandemic era: a Lombardy region survey.

Monaldi Arch Chest Dis 2021 May 4. Epub 2021 May 4.

Italian Association of Respiratory Physiotherapists (ARIR); Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.

In February 2020 the first COVID-19 case was reported in Italy and afterwards the virus started spreading rapidly, increasing dramatically the number of infected subjects. To face the pandemic outbreak, hospitals converted wards to assure COVID-19 patients' care and adopted measures to reduce virus diffusion. The aim of this study was to determine how many physiotherapists, in the Lombardy region, worked during pandemic, whether they continued their usual practice or were employed in COVID-19 wards and in which tasks they were involved. Read More

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The GLP-1 Receptor Agonist Semaglutide for the Treatment of Nonalcoholic Steatohepatitis.

Authors:
Laura E Dichtel

Hepatology 2021 May 6. Epub 2021 May 6.

Neuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

"A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis (1)," recently published in the New England Journal of Medicine (online November 2020) by Newsome et al., is an important investigation of the impact of 72 weeks of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide compared to placebo in patients with biopsy proven nonalcoholic steatohepatitis (NASH) and liver fibrosis (F1-3). GLP-1 receptor agonists are slightly modified peptides that are resistant to degradation by the dipeptidyl peptidase-4 enzyme but that mimic the effects of endogenous GLP-1, including increasing insulin secretion, decreasing glucagon production and hepatic glucose production, slowing gastric emptying and decreasing appetite (2). Read More

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