395,438 results match your criteria Cirrhosis

Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching.

Ann Rheum Dis 2022 May 20. Epub 2022 May 20.

Research Center Borstel Leibniz Lung Center, Borstel, Germany.

Objective: To determine contributions and functions of autoantibodies (Abs) directed to the angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis of AT1R Abs-related diseases such as systemic sclerosis (SSc).

Methods: C57BL/6J mice were immunised with membrane-embedded human AT1R or empty membrane as control. Mice deficient for CD4 or CD8 T cells and B cells were immunised with membrane-embedded AT1R or an AT1R peptide proposed to be a dominant T cell epitope. Read More

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Percutaneous Radiofrequency Ablation to Occlude the Thoracic Duct: Preclinical Studies in Swine for a Potential Alternative to Embolization.

J Vasc Interv Radiol 2022 May 17. Epub 2022 May 17.

Department of Medical Imaging, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724.

Purpose: To investigate the feasibility of percutaneous radiofrequency ablation (RFA) to occlude the thoracic duct (TD) in a swine model with imaging and histologic correlation.

Materials And Methods: Six swine underwent TD RFA. Two terminal (4 hours; 1 open, 1 percutaneous) and four survival (30 days; all percutaneous) studies were performed. Read More

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Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model.

Radiother Oncol 2022 May 17. Epub 2022 May 17.

Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Purpose: Preclinical studies indicate a normal tissue sparing effect when ultra-high dose rate (FLASH) radiation is used, while tumor response is maintained. This differential response has promising perspectives for improved clinical outcome. This study investigates tumor control and normal tissue toxicity of pencil beam scanning (PBS) proton FLASH in a mouse model. Read More

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Proton Pump Inhibitors for Patients with Cirrhosis: Good Medicine or Poison?

Gastroenterology 2022 May 17. Epub 2022 May 17.

Xingtai Key Laboratory of Precision Medicine for Liver Cirrhosis and Portal Hypertension, Xingtai People's Hospital of Hebei Medical University, Xingtai, Hebei, China.

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Hepatic cortical blindness: a case report and comprehensive literature review.

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Gastroenterology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an, Shaanxi, China.

Hepatic cortical blindness is an unusual clinical complication of hepatic encephalopathy, and its epidemiology has not been studied in detail. Herein, we present a case report of a 37-year-old male with liver cirrhosis and immunoglobulin A nephropathy who noted visual impairment after eating high-protein food. In addition to the case report, all previously documented cases of hepatic cortical blindness occurring across the globe published from inception until August 2019 were reviewed. Read More

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Oral submucous fibrosis induced by graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

Oral Oncol 2022 May 17;130:105919. Epub 2022 May 17.

Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University & Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha 410008, China. Electronic address:

Graft-versus-host disease (GVHD) is one of the most common and serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). About 45%∼83% of patients develop GVHD in the oral cavity. There has no medical records of oral submucous fibrosis (OSF) induced by GVHD after allo-HSCT, which should be brought to the attention of dentists. Read More

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Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis.

Thromb Res 2022 May 17;215:19-29. Epub 2022 May 17.

Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, NG7 2UH, UK. Electronic address:

Background And Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles to evaluate epidemiology of venous thromboembolism (VTE) in chronic liver disease (CLD). Read More

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Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.

Biomed Pharmacother 2022 May 17;151:113111. Epub 2022 May 17.

Department of Hepatology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan; Center for Regenerative Medicine, Kanazawa Medical University Hospital, Uchinada, Ishikawa 920-0293, Japan.

Osteopontin (OPN) is a matricellular cytokine and a stress-induced profibrogenic molecule that promotes activation of stellate cells during the pathogenesis of hepatic fibrosis. We studied the protective effects of epigallocatechin-3-gallate (EGCG) to suppress oxidative stress, inhibit OPN expression, and prevent experimentally induced hepatic fibrosis. Liver injury was induced with intraperitoneal injections of N-nitrosodimethylamine (NDMA) in a dose of 1 mg/100 g body weight on 3 consecutive days of a week for 28 days. Read More

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Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats.

Biomed Pharmacother 2022 May 17;151:113133. Epub 2022 May 17.

Department of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan. Electronic address:

Plumbagin, a natural bicyclic naphthoquinone, has diverse pharmacological properties and biological benefits against a number of disorders, including liver disease. Though plumbagin's hepatoprotective potential attracts attention, currently no experimental evidence exists on its effectiveness against cholestatic liver injury. The present study investigated its hepatoprotection in the rat model of extrahepatic cholestasis using Bile Duct Ligation (BDL). Read More

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Low-dose X-ray irradiation combined with FAK inhibitors improves the immune microenvironment and confers sensitivity to radiotherapy in pancreatic cancer.

Biomed Pharmacother 2022 May 17;151:113114. Epub 2022 May 17.

Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address:

Radiation therapy offers limited clinical benefits for patients with pancreatic cancer, partly as a result of the predominantly immunosuppressive microenvironment characteristic of this specific type of cancer. A large number of abnormal blood vessels and high-density fibrous matrices in pancreatic cancer will lead to hypoxia within tumor tissue and hinder immune cell infiltration. We used low-dose X-ray irradiation, also known as low-dose radiation therapy (LDRT), to normalize the blood vessels in pancreatic cancer, while simultaneously administering an inhibitor of focal adhesion kinase (FAK) to reduce pancreatic cancer fibrosis. Read More

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The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis.

Biomed Pharmacother 2022 May 17;151:113101. Epub 2022 May 17.

Dept. of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Nintedanib is an oral small-molecule kinase inhibitor and first-line treatment for idiopathic pulmonary fibrosis. Nintedanib is a substrate of the drug efflux transporter ABCB1. Green tea flavonoids --especially epigallocatechin gallate (EGCG)-- are potent ABCB1 modulators. Read More

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Enhanced liver fibrosis score stratifies hepatocellular carcinoma risk in patients with hepatitis B surface antigen seroclearance.

Clin Infect Dis 2022 May 20. Epub 2022 May 20.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

In this prospective study involving 337 chronic hepatitis B patients who achieved spontaneous HBsAg seroclearance (SC), serum Enhanced Liver Fibrosis (ELF) before SC was associated with hepatocellular carcinoma (HCC) (hazard ratio 2.588), and ELF <10.8 was associated with >97% reduction in risk of HCC development in patients with ageSC≥50 (n = 190). Read More

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Simplifying Treatment Criteria in Chronic Hepatitis B: Reducing Barriers to Elimination.

Clin Infect Dis 2022 May 20. Epub 2022 May 20.

Hepatitis B Foundation, Doylestown, PA, USA.

Background: Early, sustained hepatitis B virus (HBV) DNA suppression reduces long-term risks of hepatocellular carcinoma. Chronic hepatitis B (CHB) treatment criteria are complex. Simplifying criteria will improve timely linkage-to-therapy. Read More

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Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering.

Diabetes 2022 May 20. Epub 2022 May 20.

Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Patients with type 2 diabetes have a substantial risk of developing cardiovascular disease. Phosphodiesterase 4 (PDE4) dysregulation is of pathophysiological importance in metabolic disorders. To determine the role of PDE4 in diabetic cardiac dysfunction, mice fed with high-fat diet (HFD) were treated by pharmacological inhibition of PDE4 or cardiac specific knocking down of PDE4D. Read More

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3,3'-Diindolylmethane attenuates inflammation and fibrosis in radiation-induced lung injury by regulating NF-κB/TGF-β/Smad signaling pathways.

Exp Lung Res 2022 May 20:1-11. Epub 2022 May 20.

Department of Radiation Therapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang Province, China.

Objective: This study aims to investigate the protective effect of 3,3'-diindolylmethane (DIM) on the radiation-induced lung injury (RILI) model and to explore its possible mechanism. A mouse model of RILI was established by thoracic irradiation, and dexamethasone was used as a positive drug to investigate the effect of DIM on RILI mice. Lung histopathology was analyzed by HE staining and Masson staining. Read More

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Collagen 3D matrices as a model for the study of cell behavior in pulmonary fibrosis.

Exp Lung Res 2022 May 20:1-11. Epub 2022 May 20.

National Consortium of Research in Respiratory Diseases, CIBERES Instituto de Salud Carlos III, Madrid, Spain.

Idiopathic pulmonary fibrosis (IPF) is a complex progressive chronic lung disease where epithelial to mesenchymal interaction, extracellular matrix (ECM) contact, and pro-fibrotic cytokines dynamics take part in the development of the disease. The study of IPF in the widespread two-dimensional (2 D) culture fails to explain the interaction of cells with the changing environment that occurs in fibrotic lung tissue. A three-dimensional (3 D) co-culture model might shed light on the pathogenesis of IPF by mimicking the fibrotic environment. Read More

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Adipose Tissue in Lymphedema: A Central Feature of Pathology and Target for Pharmacologic Therapy.

Lymphat Res Biol 2022 May 20. Epub 2022 May 20.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Lymphedema is a chronic condition of impaired lymphatic flow that results in limb swelling and debilitation. The pathophysiology of lymphedema is characterized by lymphatic stasis that triggers inflammation, fibrosis, and adipose tissue deposition in the extremities. Most often, this condition occurs in cancer survivors in the years after treatment with combinations of surgery, radiation, or chemotherapy, with the major risk factor being lymph node dissection. Read More

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Effect of airway clearance therapies on mucociliary clearance in adults with cystic fibrosis: A randomized controlled trial.

PLoS One 2022 20;17(5):e0268622. Epub 2022 May 20.

Department of Medicine, University of North Carolina (UNC), Chapel Hill, North Carolina, United States of America.

Background: Cystic fibrosis (CF) is an inherited disorder causing impaired mucociliary clearance within the respiratory tract, and is associated with bronchiectasis, chronic respiratory infections, and early death. Airway clearance therapies have long been a cornerstone of management of individuals with CF, although evidence supporting their use is lacking. We designed a randomized controlled trial to quantitatively compare the effects of different forms of airway clearance on mucociliary clearance. Read More

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P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis.

PLoS One 2022 20;17(5):e0259727. Epub 2022 May 20.

Center of Excellence in Molecular Biology (CEMB), University of Punjab, Lahore, Pakistan.

Background & Aims: Major HCV infections lead to chronic hepatitis, which results in progressive liver disease including fibrosis, cirrhosis and eventually hepatocellular carcinoma (HCC). P2X4 and P2X7 are most widely distributed receptors on hepatocytes.

Methods: Full length P2X4 (1. Read More

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Erratum: A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease.


J Vis Exp 2022 May 20(183). Epub 2022 May 20.

An erratum was issued for: A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease. The Introduction and Protocol were updated. The first sentence of the Introduction was updated from: Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) are chronic inflammatory disorders of the gastrointestinal tract affecting approximately 20 per 1,00,000 in Europe and USA. Read More

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Incidence and Progression of Alcohol-Associated Liver Disease After Medical Therapy for Alcohol Use Disorder.

JAMA Netw Open 2022 May 2;5(5):e2213014. Epub 2022 May 2.

Alcohol Liver Center, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Alcohol-associated liver disease (ALD) is one of the most devastating complications of alcohol use disorder (AUD), an increasingly prevalent condition. Medical addiction therapy for AUD may play a role in protecting against the development and progression of ALD.

Objective: To ascertain whether medical addiction therapy was associated with an altered risk of developing ALD in patients with AUD. Read More

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Comparison between CT volumetry and extracellular volume fraction using liver dynamic CT for the predictive ability of liver fibrosis in patients with hepatocellular carcinoma.

Eur Radiol 2022 May 20. Epub 2022 May 20.

Departments of Digestive Surgery Nihon University School of Medicine, Tokyo, Japan.

Objectives: To compare the predictive ability of liver fibrosis (LF) by CT-volumetry (CTV) for liver and spleen and extracellular volume fraction (ECV) for liver in patients undergoing liver resection.

Methods: We retrospectively analysed 90 consecutive patients who underwent CTV and ECV. Manually placed region-of-interest ECV (manual-ECV), rigid-registration ECV (rigid-ECV), and nonrigid-registration ECV (nonrigid-ECV) were calculated as ECV(%) = (1-haematocrit) × (ΔHU/ΔHU), where ΔHU = subtraction of unenhanced phase from equilibrium phase (240 s). Read More

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Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis.

Geroscience 2022 May 20. Epub 2022 May 20.

Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute On Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1 mouse model of congenital hepatic fibrosis.

FASEB J 2022 Jun;36(6):e22364

Department of Molecular Medicine (DMM), University of Padova, Padova, Italy.

Congenital hepatic fibrosis (CHF), a genetic cholangiopathy characterized by fibropolycystic changes in the biliary tree, is caused by mutations in the PKHD1 gene, leading to defective fibrocystin (FPC), changes in planar cell polarity (PCP) and increased β-catenin-dependent chemokine secretion. In this study, we aimed at understanding the role of Scribble (a protein involved in PCP), Yes-associated protein (YAP), and β-catenin in the regulation of the fibroinflammatory phenotype of FPC-defective cholangiocytes. Immunohistochemistry showed that compared with wild type (WT) mice, in FPC-defective (Pkhd1 ) mice nuclear expression of YAP/TAZ in cystic cholangiocytes, significantly increased and correlated with connective tissue growth factor (CTGF) expression and pericystic fibrosis, while Scribble expression on biliary cyst cells was markedly decreased. Read More

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Morphological and immunophenotypic characteristics of the liver of swine naturally infected with hepatitis E virus.

Vet Ital 2021 Dec 31;57(4):287-295. Epub 2021 Dec 31.

University Clinical Center of Serbia, Clinic for Digestive Surgery, Belgrade, Serbia.

Hepatitis E virus (HEV), the zoonotic agent of infectious hepatitis, is present in swine farms in different geographical areas. Little is known about the mechanism of liver damage and type of local immune response by HEV in swine. Therefore, the aim of this study was to determine the morphological and immunophenotypic characteristics of hepatic lesions caused by hepatitis E virus in naturally infected swine. Read More

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December 2021

An update on the functional roles of long non‑coding RNAs in ischemic injury (Review).

Int J Mol Med 2022 Jul 20;50(1). Epub 2022 May 20.

Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang, Jiangxi 330006, P.R. China.

Ischemic injuries result from ischemia and hypoxia in cells. Tissues and organs receive an insufficient supply of nutrients and accumulate metabolic waste, which leads to the development of inflammation, fibrosis and a series of other issues. Ischemic injuries in the brain, heart, kidneys, lungs and other organs can cause severe adverse effects. Read More

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Towards a more precise classification of esophageal motility disorders in patients with systemic sclerosis.

Neurogastroenterol Motil 2022 May 20:e14416. Epub 2022 May 20.

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Systemic sclerosis (SSc) is a chronic and generalized disease affecting the connective tissue of the skin and many internal organs, in particular the gastrointestinal tract. The esophagus is involved in up to 80% of the cases and represents a major cause of serious morbidities that deeply impact on the quality of life and survival of patients. Indeed, the presence of esophageal dysfunction is a good prognostic indicator in SSc, primarily due to its impact on pulmonary disease. Read More

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