323,865 results match your criteria Cirrhosis


A 9-months multidisciplinary rehabilitation protocol based on early post-operative mobilization following a chronic-degenerative patellar tendon rupture in a professional soccer player: a case report.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Isolated patellar tendon rupture (PTR) is the final stage of a long-standing tendon chronic degeneration. PTR requires immediate repair in order to avoid important muscle retraction and tendon fibrosis. The aim was to describe the effects of a rehabilitation protocol after chronic-degenerative PTR on subjective functional outcomes, knee range of motion (ROM), size, and strength in a professional football player. Read More

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December 2018

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study.

Adv Ther 2018 Dec 13. Epub 2018 Dec 13.

Novartis Healthcare Pvt Ltd, Hyderabad, India.

Introduction: The aim of this work was to understand how patients with non-alcoholic steatohepatitis (NASH) perceive their disease, unmet needs, and expectations regarding future treatment through online bulletin board (OBB) qualitative research.

Methods: OBB is an asynchronous online qualitative market research tool that provides an open forum for interactive discussion among participants. Patients with NASH were recruited via physician referral and completed a screener questionnaire to ensure their eligibility and willingness to participate. Read More

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December 2018

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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December 2018

Increases in cytosolic Ca induce dynamin- and calcineurin-dependent internalisation of CFTR.

Cell Mol Life Sci 2018 Dec 13. Epub 2018 Dec 13.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previously shown that cigarette smoke (CS) exposure to airway epithelia causes a reduction in plasma membrane CFTR expression which correlated with a decrease in airway surface hydration. The effect of CS on CFTR was dependent on an increase in cytosolic Ca. Read More

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December 2018

Hepatobiliary phase in cirrhotic patients with different Model for End-stage Liver Disease score: comparison of the performance of gadoxetic acid to gadobenate dimeglumine.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.

Objectives: The purpose of this study was to compare the performance of gadobenate dimeglumine-enhanced MRI and gadoxetic acid-enhanced MRI in the hepatobiliary phase (HBP) in cirrhotic patients with different degrees of liver dysfunction.

Methods: In this retrospective cross-sectional study, we analyzed the unenhanced phase and the HBP of 131 gadobenate dimeglumine-enhanced MRI examinations (gadobenate dimeglumine group) and 127 gadoxetic acid-enhanced MRI examinations (gadoxetic acid group) performed in 249 cirrhotic patients (181 men and 68 women; mean age, 64.8 years) from August 2011 to April 2017. Read More

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December 2018

IVIM with fractional perfusion as a novel biomarker for detecting and grading intestinal fibrosis in Crohn's disease.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Objectives: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard.

Methods: Twenty-four adults with CD underwent preoperative IVIM, traditional diffusion-weighted, and contrast-enhanced imaging. Read More

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December 2018

Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

The Role of Anticoagulation in Treating Portal Hypertension.

Curr Hepatol Rep 2018 18;17(3):200-208. Epub 2018 Jun 18.

1Division of Gastroenterology, Azienda Ospedaliero-Universitaria di Modena and University of Modena and Reggio Emilia, Modena, Italy.

Purpose Of Review: To revise experimental and clinical data supporting a less traditional role of anticoagulation for treating portal hypertension in patients with cirrhosis.

Recent Findings: Portal hypertension is the main driver of complications such as ascites, variceal hemorrhage, and hepatic encephalopathy, with inflammation as a key component. The traditional view of cirrhosis as a pro-hemorrhagic condition has recently changed, prothrombotic complications being recognized as frequently as the hemorrhagic ones. Read More

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Fatigued Patients with Chronic Liver Disease Have Subtle Aberrations of Sleep, Melatonin and Cortisol Circadian Rhythms.

Fatigue 2018 3;6(1):5-19. Epub 2017 Dec 3.

Liver & Energy Metabolism Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Aims: We sought to examine whether disturbances in central and peripheral circadian rhythms were related to the experience of fatigue in patients with chronic liver disease (CLD).

Methods: Fatigued and non-fatigued patients with compensated CLD were enrolled in a prospective pilot study. Patients underwent a one week evaluation of free-living sleep and physical activity patterns, followed by a 24-hour admission, during which they underwent serial blood sampling, polysomnography, a 6-minute walk test and continuous core temperature measurements under standardized conditions. Read More

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December 2017
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Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR .

Comput Struct Biotechnol J 2018 10;16:587-599. Epub 2018 Nov 10.

Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville 3010, VIC, Australia.

Polymyxins are amongst the most important antibiotics in modern medicine, in recent times their clinical utility has been overshadowed by nosocomial outbreaks of polymyxin resistant MDR Gram-negative 'superbugs'. An effective strategy to surmount polymyxin resistance is combination therapy with FDA-approved non-antibiotic drugs. Herein we used untargeted metabolomics to investigate the mechanism(s) of synergy between polymyxin B and the selective estrogen receptor modulator (SERM) tamoxifen against a polymyxin-resistant MDR cystic fibrosis (CF) FADDI-PA006 isolate (polymyxin B MIC=8 mg/L , it is an MDR polymyxin resistant isolated from the lungs of a CF patient). Read More

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November 2018

The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury.

Oncotarget 2018 Nov 16;9(90):36185-36201. Epub 2018 Nov 16.

Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.

Renal ischemia/reperfusion (I/R) injury occurs in patients undergoing renal transplantation and with acute kidney injury and is responsible for the development of chronic allograft dysfunction as characterized by parenchymal alteration and fibrosis. Heparanase (HPSE), an endoglycosidase that regulates EMT and macrophage polarization, is an active player in the biological response triggered by ischemia/reperfusion (I/R) injury. I/R was induced by clamping left renal artery for 30 min in wt C57BL/6J mice. Read More

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November 2018

Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma.

Oncotarget 2018 Nov 8;9(90):36057-36066. Epub 2017 Dec 8.

Beijing 302 Hospital, Beijing, 100039, China.

Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long intergenic noncoding RNAs (lincRNAs) play central roles in the development of HCC. Read More

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November 2018

Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma.

Oncol Lett 2018 Dec 3;16(6):7123-7130. Epub 2018 Oct 3.

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China.

Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. Read More

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December 2018

Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.

Oncol Lett 2018 Dec 2;16(6):7057-7067. Epub 2018 Oct 2.

The Gerontology Institute of Anhui Province, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China.

Lung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to determine EGFR mutation characteristics and identify their significance in patients with resected lung MIA. Read More

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December 2018

Rare case of idiopathic sclerosing cholangitis, which was difficult to distinguish from cholangiocarcinoma: A case report.

Exp Ther Med 2018 Dec 5;16(6):5224-5226. Epub 2018 Oct 5.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.

It is often difficult to correctly diagnose patients who present with dilation of the bile duct. Cholangiocarcinoma, primary sclerosing cholangitis (PSC) and immunoglobulin (Ig)G4-related sclerosing cholangitis must be considered as potential diagnoses for these cases. The current study presents a 73-year-old female patient who presented with a high fever and abdominal pain. Read More

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December 2018

Host Regulators of Liver Fibrosis During Human Schistosomiasis.

Front Immunol 2018 28;9:2781. Epub 2018 Nov 28.

Cape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa.

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. Read More

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November 2018

Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis.

Front Pharmacol 2018 28;9:1330. Epub 2018 Nov 28.

Telethon Kids Institute, Perth, WA, Australia.

Antimicrobial-resistant microbes are an increasing threat to human health. In cystic fibrosis (CF), airway infections with remain a key driver of lung damage. With few new antibiotics on the development horizon, alternative therapeutic approaches are needed against antimicrobial-resistant pathogens. Read More

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November 2018
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Complete Recovery of Oxysterol 7α-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review.

J Korean Med Sci 2018 Dec 22;33(51):e324. Epub 2018 Nov 22.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. Read More

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December 2018

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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December 2018

Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation.

Sci Rep 2018 Dec 13;8(1):17834. Epub 2018 Dec 13.

Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Next to progressive airway disease, CF is also associated with intestinal inflammation and dysbiosis. Ivacaftor, a CFTR potentiator, has improved pulmonary and nutritional status but its effects on the intestinal microbiota and inflammation are unclear. Read More

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December 2018
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Publisher Correction: Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function.

Sci Rep 2018 Dec 13;8(1):17946. Epub 2018 Dec 13.

Department of Paediatric Respiratory Medicine, School for Public Health and Primary Health Care (CAPHRI), Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.

J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, University of Michigan, Ann Arbor, Michigan; and

Background: Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a process that includes a decrease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.

Methods: To investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis, we used microarrays to analyze gene expression patterns among fibroblast populations at different stages of injury or repair. Read More

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December 2018

Targeting interleukin-13 in idiopathic pulmonary fibrosis: from promising path to dead end.

Eur Respir J 2018 Dec 13;52(6). Epub 2018 Dec 13.

National Reference Center for Rare Pulmonary Disease, Louis Pradel Hospital; UMR754, Claude Bernard University, Lyon, France.

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December 2018

Influence of Inspiratory/Expiratory CT Registration on Quantitative Air Trapping.

Acad Radiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, University of Michigan, Ann Arbor, MI 48109. Electronic address:

Rationale And Objectives: The aim of this study was to assess variability in quantitative air trapping (QAT) measurements derived from spatially aligned expiration CT scans.

Materials And Methods: Sixty-four paired CT examinations, from 16 school-age cystic fibrosis subjects examined at four separate time intervals, were used in this study. For each pair, visually inspected lobe segmentation maps were generated and expiration CT data were registered to the inspiration CT frame. Read More

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December 2018

Limited performance of subjective global assessment compared to computed tomography-determined sarcopenia in predicting adverse clinical outcomes in patients with cirrhosis.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada. Electronic address:

Background & Aims: The subjective global assessment (SGA) is commonly used to assess nutritional status in patients with cirrhosis. Sarcopenia, a major component of malnutrition, is associated with survival in cirrhosis, and can be objectively diagnosed by computing the skeletal muscle index (SMI) using cross-sectional imaging. The aim of this study was to assess the prevalence of sarcopenia between SGA categories in patients with cirrhosis, and to determine their association with decompensation/mortality. Read More

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November 2018

Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Renal fibrosis is the final common pathway of various renal injuries and it leads to chronic kidney disease. Recent studies reported that FOXD1-lineage pericyte plays a critical role in tubulointerstitial fibrosis (TIF). However the regulatory mechanisms remain unclear. Read More

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December 2018

Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution.

BMC Struct Biol 2018 Dec 13;18(1):17. Epub 2018 Dec 13.

School of Biology, Faculty of Biology Medicine and Health, Michael Smith Building, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: P-glycoprotein (ABCB1) is an ATP-binding cassette transporter that plays an important role in the clearance of drugs and xenobiotics and is associated with multi-drug resistance in cancer. Although several P-glycoprotein structures are available, these are either at low resolution, or represent mutated and/or quiescent states of the protein.

Results: In the post-hydrolytic state the structure of the wild-type protein has been resolved at about 8 Å resolution. Read More

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December 2018

Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature.

Biomedicines 2018 Dec 11;6(4). Epub 2018 Dec 11.

Fondazione Novara Sviluppo, 28100 Novara, Italy.

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Read More

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December 2018
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Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma.

Nutrients 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, Osaka-Rosai Hospital, 1179-3 Nagasone, Kitaku, Sakai, Osaka 591-8025, Japan.

Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis progresses. Whether long-term zinc supplementation improves liver function and reduces the risk of hepatocellular carcinoma (HCC) development remains unknown. Read More

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December 2018

The Role of Occupational and Environmental Exposures in the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Narrative Literature Review.

Medicina (Kaunas) 2018 Dec 10;54(6). Epub 2018 Dec 10.

Birmingham Regional NHS Occupational Lung Disease Service, Birmingham Chest Clinic, Birmingham B33HX, UK.

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by a progressive and irreversible decline in lung function, which is associated with poor long-term survival. The pathogenesis of IPF is incompletely understood. An accumulating body of evidence, obtained over the past three decades, suggests that occupational and environmental exposures may play a role in the development of IPF. Read More

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December 2018

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan.

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO inhibitor administration for IgA nephropathy. We thus investigated whether febuxostat, an XO inhibitor, exerts a protective effect against the development of IgA nephropathy, using gddY mice as an IgA nephropathy rodent model. Read More

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December 2018
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miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.

Nonalcoholic fatty liver disease (NAFLD) defines a wide pathological spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) which may predispose to liver cirrhosis and hepatocellular carcinoma. It represents the leading cause of hepatic damage worldwide. Diagnosis of NASH still requires liver biopsy but due to the high prevalence of NAFLD, this procedure, which is invasive, is not practicable for mass screening. Read More

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December 2018

Cardiac tamponade after radiofrequency ablation for hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Dec;97(49):e13532

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA. Read More

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December 2018

Oral oxymatrine for hepatitis B cirrhosis: A systematic review protocol.

Medicine (Baltimore) 2018 Dec;97(49):e13482

Acupuncture and massage department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance. Read More

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December 2018

Arterial involvement in Erdheim-Chester disease: A retrospective cohort study.

Medicine (Baltimore) 2018 Dec;97(49):e13452

Division of Rheumatology.

Erdheim-Chester disease (ECD) is a rare histiocytosis of the "L" (Langerhans) group with multisystem involvement that can affect the large and medium-sized arteries mimicking vasculitis. Aortic involvement is common but the frequency and outcome of aortic branch vessel abnormalities are less well described.Patients with ECD were retrospectively identified. Read More

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December 2018

Hyponatremia: Prevalence and characteristics in internal medicine patients in southeast of China.

Medicine (Baltimore) 2018 Dec;97(49):e13389

Department of Endocrinology and Metabolism, The First Hospital of Jilin University.

To determine the incidence, clinical features, etiology, risk factors, and mortality in internal medicine patients with hyponatremia (P-Na).A prospective survey was conducted in patients with P-Na, diagnosed at admission in an Internal Medicine Department. 692 patients were then selected and subsequently divided into 3 groups based on the severity of P-Na. Read More

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December 2018

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

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December 2018

Insight into the role of TRAIL in liver diseases.

Biomed Pharmacother 2018 Dec 10;110:641-645. Epub 2018 Dec 10.

Center of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, China. Electronic address:

TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an essential role in viral hepatitis, fatty liver diseases, etc. Read More

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December 2018

Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p/ transforming growth factor β type II receptor axis.

Chemosphere 2018 Dec 3;219:268-276. Epub 2018 Dec 3.

College of Environmental Science and Resources, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:

SO and PAHs are well-known pollutants of coal burning and significant contributors to haze episodes. The purpose of the study is to determine whether the combined effects of SO and BaP are synergetic and to investigate the pro-fibrotic influences and possible mechanism from the aspect of microRNAs. In the present study cellular metabolic activity of BEAS-2B was assessed using MTT probe. Read More

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December 2018

Intravenous Immunoglobulin (IVIG) in the vanguard therapy of Systemic Sclerosis.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Sackler Faculty of Medicine, Tel Aviv University, Israel; Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by a progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to a multisystemic dysfunction. Various pathogenetic mechanisms were described. The lack of a successful therapy make SSc a disease with a poor prognosis. Read More

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December 2018

RIGHT VENTRICULAR FUNCTIONAL RESERVE IN EARLY STAGE IDIOPATHIC PULMONARY FIBROSIS: AN EXERCISE TWO DIMENSIONAL SPECKLE TRACKING DOPPLER ECHOCARDIOGRAPHY STUDY On Behalf of The RIGHT Heart International NETwork (RIGHT-NET) Investigators.

Chest 2018 Dec 10. Epub 2018 Dec 10.

'Cava de' Tirreni and Amalfi Coast' Hospital, Division of Cardiology, Heart Department, University Hospital, Salerno, Italy.

Background: The most important determinant of long term survival in idiopathic pulmonary fibrosis (IPF) patients is the adaptation of the right ventricle (RV) to the increased pulmonary vascular resistance. Our aim was to explore RV contractile reserve during stress echocardiography (SE) in early stage IPF.

Methods: 50 early stage IPF patients and 50 healthy controls underwent rest and SE, including RV 2-dimensional Speckle Tracking Echocardiography (2DSTE). Read More

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December 2018

RE: No Association Between Screening for Hepatocellular Carcinoma and Reduced Cancer-Related Mortality in Patients with Cirrhosis.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Victoria, Australia; Monash University, Melbourne, Victoria, Australia.

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December 2018

Screening For Hepatocellular Carcinoma In Cirrhosis: Challenges And Unresolved Issues.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, Larner College of Medicine, University of Vermont; University of Vermont Medical Center. Electronic address:

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December 2018

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.

Chem Biol Interact 2018 Dec 10. Epub 2018 Dec 10.

College of Pharmacy, Guilin Medical University, Guilin, 541004, PR China. Electronic address:

Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential role in the pathogenesis of liver fibrosis. Methyl ferulic acid (MFA), a biologically active monomer, has a protective effect on liver injury. Read More

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December 2018

Serum alkaline phosphatase levels as a simple and useful test in screening for significant fibrosis in treatment-naive patients with hepatitis B e-antigen negative chronic hepatitis B.

Eur J Gastroenterol Hepatol 2018 Dec 12. Epub 2018 Dec 12.

Background: Staging of liver fibrosis is critical in guiding the treatment of chronic hepatitis B (CHB) virus. Many efforts have been made toward the research of noninvasive techniques, mostly focusing on hepatitis B e-antigen (HBeAg)-positive [HBeAg(+)] CHB patients, whereas HBeAg(+) and HBeA-negative [HBeAg(-)] represent different stages of hepatitis B virus infection. Thus, in this study, we aimed to search for routinely available clinical noninvasive liver fibrosis markers and separately analysed the markers in HBeAg(+) and HBeAg(-) CHB patients. Read More

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December 2018

Liver Repair and Regeneration after Ischemia/Reperfusion Injury is Associated with Prolonged Fibrosis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery and Institute for Military Medicine, University of Cincinnati, United States.

Liver recovery after hepatic ischemia/reperfusion (I/R) injury is characterized by clearance of dead tissue and its replacement with functional liver parenchyma. Previous reports have observed fibrosis after liver I/R. In order to determine if liver fibrosis after I/R was a pathologic consequence of the injury response, we assessed the development of liver fibrosis after I/R and its impact on subsequent insult. Read More

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December 2018

Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2018 Dec 13. Epub 2018 Dec 13.

Brigham and Women\'s Hospital, 1861, Medicine, Boston, Massachusetts, United States ;

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede the development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data from imaging studies.

Objectives: To assess quantitative measures of airway wall thickness (AWT) in populations characterized for interstitial lung abnormalities (ILA) and for IPF.

Methods: Chest computed tomography scans (CTs) and measures of AWT were available on 6073, 615, 1167, and 38 participants from COPDGene, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE), the Framingham Heart Study (FHS), and in IPF patients from the Brigham and Women's Hospital Herlihy Registry, respectively. Read More

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December 2018

2018 Clinical Practice Guideline Summary For Practicing Clinicians: Diagnosis of Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2018 Dec 13. Epub 2018 Dec 13.

University of Washington Medical Center, 21617, Division of Pulmonary and Critical Care Medicine, Seattle, Washington, United States.

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December 2018

Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.

Am J Respir Cell Mol Biol 2018 Dec 13. Epub 2018 Dec 13.

Medical University of South Carolina, Medicine, Charleston, South Carolina, United States.

Idiopathic Pulmonary Fibrosis (IPF) pathogenesis has been postulated to involve a variety of mechanisms associated with the aging process, including loss of protein homeostasis (proteostasis). Heat shock proteins (Hsp) are cellular chaperones that serve a number of vital maintenance and repair functions, including the regulation of proteostasis. Previously published data have implicated Hsp70 in the development of pulmonary fibrosis in animal models. Read More

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December 2018