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    16850 results match your criteria Circulation research[Journal]

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    Endothelial TFEB Positively Regulates Post-Ischemic Angiogenesis.
    Circ Res 2018 Feb 21. Epub 2018 Feb 21.
    Cardiovascular Center, University of Michigan Medical Center
    Post-ischemic angiogenesis is critical to limit the ischemic tissue damage and improve the blood flow recovery. The regulation and the underlying molecular mechanisms of post-ischemic angiogenesis are not fully unraveled. Transcription factor-EB (TFEB) is emerging as a master gene for autophagy and lysosome biogenesis. Read More

    Reflection of Cardioprotection by Remote Ischemic Perconditioning in Attenuated ST-Segment Elevation During Ongoing Coronary Occlusion in Pigs: Evidence for Cardioprotection from Ischemic Injury.
    Circ Res 2018 Feb 21. Epub 2018 Feb 21.
    Institute for Pathophysiology, University of Essen Medical School
    Reduction of infarct size (IS) by remote ischemic per-conditioning (perRIC) is evident only after several hours reperfusion.To develop a potential real-time estimate of cardioprotection by perRIC we have analyzed the time course of ST-segment elevation.Anesthetized open-chest pigs were subjected to 60 min coronary occlusion and 180 min reperfusion (placebo; PLA; n=19). Read More

    Specific Activation of the Alternative Cardiac Promoter ofby the Mineralocorticoid Receptor.
    Circ Res 2018 Feb 21. Epub 2018 Feb 21.
    Inserm UMR-S 1180
    The mineralocorticoid receptor (MR) antagonists belong to the current therapeutic armamentarium for the management of cardiovascular diseases, but the mechanisms conferring their beneficial effects are poorly understood. Part of the cardiovascular effects of MR are due to the regulation of L-type Ca1.2 Cachannel expression, which is generated by tissue-specific alternative promoters as a long 'cardiac' (Ca1. Read More

    Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity.
    Circ Res 2018 Feb;122(4):624-638
    From the Diabetes and Cardiovascular Research Center (G.J., J.R.S.) and Department of Medical Pharmacology and Physiology (M.A.H., J.R.S.), University of Missouri School of Medicine, Columbia; Dalton Cardiovascular Research Center, University of Missouri, Columbia (M.A.H., J.R.S.); and Research Service, Truman Memorial Veterans Hospital, Columbia, MO (G.J., J.R.S.).
    Heart failure and related morbidity and mortality are increasing at an alarming rate, in large part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes associated with heart failure are considerably worse for patients with diabetes mellitus than for those without diabetes mellitus. In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia, has led to the descriptive terminology, diabetic cardiomyopathy. Read More

    Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility.
    Circ Res 2018 Feb 15. Epub 2018 Feb 15.
    Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
    The promising clinical benefits of delivering human mesenchymal stem cells (hMSCs) for treating heart disease warrant a better understanding of underlying mechanisms of action. hMSC exosomes increase myocardial contractility; however, the exosomal cargo responsible for these effects remains unresolved.This study aims to identify lead cardioactive hMSC exosomal microRNAs to provide a mechanistic basis for optimizing future stem cell-based cardiotherapies. Read More

    Non-Invasive Immuno-Metabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance.
    Circ Res 2018 Feb 12. Epub 2018 Feb 12.
    Physiology, Anatomy and Genetics, University of Oxford
    Current cardiovascular clinical imaging techniques offer only limited assessment of innate immune cell driven inflammation, which is a potential therapeutic target in myocardial infarction (MI) and other diseases. Hyperpolarized magnetic resonance (MR) is an emerging imaging technology that generates contrast agents with 10-20,000 fold improvements in MR signal, enabling cardiac metabolite mapping.To determine whether hyperpolarized MR using [1-C]pyruvate can assess the local cardiac inflammatory response following MI. Read More

    Network Analysis to Risk Stratify Patients with Exercise Intolerance.
    Circ Res 2018 Feb 5. Epub 2018 Feb 5.
    Cardiovascular Medicine, Brigham and Women's Hospital
    Current methods assessing clinical risk due to exercise intolerance in cardiopulmonary disease patients rely on a small subset of traditional variables. Alternative strategies incorporating the spectrum of factors underlying prognosis in at-risk patients may be useful clinically, but are lacking.Use unbiased analyses to identify variables that correspond to clinical risk in patients with exercise intolerance. Read More

    Impaired Production and Diurnal Regulation of Vascular RvDIncreases Systemic Inflammation and Cardiovascular Disease.
    Circ Res 2018 Feb 5. Epub 2018 Feb 5.
    William Harvey Research Institute, Queen Mary University of London
    Diurnal mechanisms are central to regulating host responses. Recent studies uncovered a novel family of mediators termed as specialized pro-resolving mediators (SPM) that terminate inflammation without interfering with the immune response. Little is known on their diurnal regulation. Read More

    Deficiency of Complement C3a and C5a Receptors Prevents Angiotensin II-Induced Hypertension via Regulatory T Cells.
    Circ Res 2018 Feb 5. Epub 2018 Feb 5.
    Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine
    Inflammation and immunity play crucial roles in the development of hypertension. Complement activation-mediated innate immune response is involved in the regulation of hypertension and target organ damage. However, whether complement-mediated T cell functions could regulate blood pressure (BP) elevation in hypertension is still unclear. Read More

    Deletion of IRF8-Dependent Dendritic Cells Abrogates Pro-Atherogenic Adaptive Immunity.
    Circ Res 2018 Feb 7. Epub 2018 Feb 7.
    Cardiovascular Medicine, University of Cambridge
    Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood.Here, we address the role of IRF8-dependent DCs (lymphoid CD8αand their developmentally related non-lymphoid CD103DCs) in the induction of pro-atherogenic immune responses during high fat feeding.Using a fate mapping technique to track DCs originating from a DNGR1precursor (mice), we first show that YFPMCD11cMHCIIDCs are present in the atherosclerotic aorta of low-density lipoprotein receptor deficient () mice and are CD11b-CD103IRF8Restricted deletion of IRF8 in DCs () reduces the accumulation of CD11cMHCIIDCs in the aorta without affecting CD11bCD103DCs or macrophages, but completely abolishes the accumulation of aortic CD11bCD103DCs. Read More

    Do Dipeptidyl Peptidase-4 Inhibitors Cause Heart Failure Events by Promoting Adrenergically-Mediated Cardiotoxicity? Clues from Laboratory Models and Clinical Trials.
    Circ Res 2018 Feb 7. Epub 2018 Feb 7.
    Baylor Heart and Vascular Institute, Baylor University Medical Center
    Dipeptidyl peptidase-4 (DPP-4) inhibitors have increased the risk of heart failure events in both randomized clinical trials and observational studies, but the mechanisms that underlie their deleterious effect remain to be elucidated. Previous work has implicated a role of these drugs to promote cardiac fibrosis.This paper postulates that DPP-4 inhibitors increase the risk of heart failure events by activating the sympathetic nervous system to stimulate cardiomyocyte cell death, and it crystallizes the findings from both experimental studies and clinical trials that support the hypothesis. Read More

    Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.
    Circ Res 2018 Feb;122(3):523-532
    From the Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA.
    Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of aging, its relevance in cardiovascular disease or other age-related conditions has been, with the exception of cancer, largely unexplored. Here, we review recent clinical and preclinical studies that have identified acquired mutations in hematopoietic stem cells and subsequent clonal hematopoiesis as a new cardiovascular risk factor and a potential major driver of atherosclerosis. Read More

    Translational Implications of Platelets as Vascular First Responders.
    Circ Res 2018 Feb;122(3):506-522
    From the Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, OH (R.C.B.); and Gill Heart and Vascular Institute (T.S., S.S.S.) and Lexington VA Medical Center (T.S., S.S.S.), University of Kentucky School of Medicine.
    Platelets play a vital role in normal hemostasis to stem blood loss at sites of vascular injury by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the developing clot, releasing vasoactive small molecules and proteins, and assembling and activating plasma coagulation proteins in a tightly regulated temporal and spatial manner. In synchrony with specific end products of coagulation, primarily cross-linked fibrin, a stable thrombus quickly forms. Far beyond physiological hemostasis and pathological thrombosis, emerging evidence supports platelets playing a pivotal role in vascular homeostasis, inflammation, cellular repair, regeneration, and wide range of autocrine and paracrine functions. Read More

    New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
    Circ Res 2018 Feb;122(3):489-505
    From the Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (S.S., G.F.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (S.S., M.F., G.F.); and Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark (J.S.).
    The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2). In the cardiovascular system, the mTOR pathway regulates both physiological and pathological processes in the heart. Read More

    Boosting Endothelial Autophagy by MicroRNA Delivery Quenches Vascular Inflammation.
    Circ Res 2018 Feb;122(3):388-390
    From the Toronto General Hospital Research Institute, University Health Network, Canada (K.R., J.E.F.); Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada (K.R., J.E.F.); and Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada (J.E.F.).

    Enhanced Redox State and Efficiency of Glucose Oxidation with miR Based Suppression of Maladaptive NADPH-Dependent Malic Enzyme 1 Expression in Hypertrophied Hearts.
    Circ Res 2018 Jan 31. Epub 2018 Jan 31.
    Internal Medicine, The Ohio State University Wexner Medical Center
    Metabolic remodeling in hypertrophic hearts includes inefficient glucose oxidation via increased anaplerosis fueled by pyruvate carboxylation. Pyruvate carboxylation to malate through elevated malic enzme-1 (ME1) consumes NADPH necessary for reduction of glutathione and maintenance of intracellular redox state.To elucidate upregulated ME1 as a potential maladaptive mechanism for inefficient glucose oxidation and compromised redox state in hypertrophied hearts. Read More

    Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart.
    Circ Res 2018 Jan 26. Epub 2018 Jan 26.
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    Endocardium is the major source of coronary endothelial cells in the fetal and neonatal hearts. It remains unclear whether endocardium in the adult stage is also the main origin of neovascularization after cardiac injury.To define the vascular potential of adult endocardium in homeostasis and after cardiac injuries by fate mapping studies. Read More

    Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.
    Circ Res 2018 Jan 26. Epub 2018 Jan 26.
    Institute of Pharmacology and Structural Biology, UMR5089 CNRS/UPS.
    Heart development involves differentiation of cardiac progenitors and assembly of the contractile sarcomere apparatus of cardiomyocytes. However, little is known about the mechanisms that regulate actin cytoskeleton remodeling during cardiac cell differentiation.The Asb2α Cullin5 RING E3 ubiquitin ligase triggers polyubiquitylation and subsequent degradation by the proteasome of filamins. Read More

    Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis.
    Circ Res 2018 Jan 24. Epub 2018 Jan 24.
    Internal Medicine, Radboud University Medical Center
    There is strong epidemiological evidence for an association between acute and chronic infections and the occurrence of atherosclerotic cardiovascular disease (ASCVD). The underlying pathophysiological mechanisms remain unclear. Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. Read More

    Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease.
    Circ Res 2018 Jan 24. Epub 2018 Jan 24.
    Regenerative Medicine, Okayama University Hospital
    Intracoronary administration of cardiosphere-derived cells (CDCs) in patients with single ventricles resulted in a short-term improvement in cardiac function.To test the hypothesis that CDC infusion is associated with improved cardiac function and reduced mortality in patients with heart failure.We evaluated the effectiveness of CDCs using an integrated cohort study in 101 patients with single ventricles, including 41 patients that received CDC infusion and 60 controls treated with staged palliation alone. Read More

    Down Syndrome Critical Region 1 Gene,, Helps Maintain a More Fused Mitochondrial Network.
    Circ Res 2018 Jan 23. Epub 2018 Jan 23.
    Internal Medicine, University of Texas Southwestern Medical Center
    The Regulator of Calcineurin 1 (RCAN1) inhibits calcineurin (CN), a Ca-activated protein phosphatase important in cardiac remodeling. In humans,is located on chromosome 21 in proximity to the "Down syndrome critical region." The hearts and brains ofKO mice are more susceptible to damage from ischemia/reperfusion (I/R), however, the underlying cause is not known. Read More

    Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization.
    Circ Res 2018 Jan 22. Epub 2018 Jan 22.
    Institute for Cardiovascular Regeneration, Goethe University
    Vascularization is critical to maintain organ function. Although many molecular pathways were shown to control vessel growth, the genuine process of capillary formation under different conditions is unclear.Here, we elucidated whether clonal expansion contributes to vessel growth by using Confetti mice for genetic tracing of clonally expanding endothelial cells. Read More

    E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells.
    Circ Res 2018 Jan 22. Epub 2018 Jan 22.
    Biomedical Engineering, University of Alabama at Birmingham
    The majority of current cardiovascular cell-therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major barriers to the success of this promising therapy. We have previously reported that the E2F transcription factor 1 (E2F1) is a repressor of neovascularization following ischemic injury.We sought to define the role of E2F1 in the regulation of BM PC function. Read More

    Inflammatory Pathways Regulated By Tumor-Necrosis Receptor Associated Factor 1 Protect From Metabolic Consequences In Diet-Induced Obesity.
    Circ Res 2018 Jan 22. Epub 2018 Jan 22.
    Inflammation Biology, La Jolla Institute.
    The co-incidence of inflammation and metabolic derangements in obese adipose tissue has sparked the concept of met-inflammation. Previous observations, however, suggest that inflammatory pathways may not ultimately cause dysmetabolism.We have revisited the relationship between inflammation and metabolism by testing the role of Tumor-Necrosis Receptor associated Factor (TRAF)-1, an inhibitory adapter of inflammatory signaling of TNFα, IL-1β, and TLRs. Read More

    Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis.
    Circ Res 2018 Jan 19. Epub 2018 Jan 19.
    Physiology and Biophysics, Rush University
    Atrial fibrillation (AF) is the most common arrhythmia and advanced age is an inevitable and predominant AF risk factor. However, the mechanisms that couple aging and AF propensity remain unclear, making targeted therapeutic interventions unattainable.To explore the functional role of an important stress-response c-Jun N-terminal kinase (JNK) in sarcoplasmic reticulum (SR) Cahandling and consequently Ca-mediated atrial arrhythmias. Read More

    Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health: A Review of Emerging Biologic Pathways.
    Circ Res 2018 Jan;122(2):369-384
    From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.); and the George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (J.H.Y.W.).
    A growing body of nutritional science highlights the complex mechanisms and pleiotropic pathways of cardiometabolic effects of different foods. Among these, some of the most exciting advances are occurring in the area of flavonoids, bioactive phytochemicals found in plant foods; and in the area of dairy, including milk, yogurt, and cheese. Many of the relevant ingredients and mechanistic pathways are now being clarified, shedding new light on both the ingredients and the pathways for how diet influences health and well-being. Read More

    Hypertension and Atrial Fibrillation: Doubts and Certainties From Basic and Clinical Studies.
    Circ Res 2018 Jan;122(2):352-368
    From the Struttura Complessa di Medicina, Dipartimento di Medicina, Ospedale di Assisi, Italy (P.V.); and Struttura Complessa di Cardiologia e Fisiopatologia Cardiovascolare, Dipartimento di Cardiologia (F.A.) and Dipartimento di Medicina Interna (G.R.), Università di Perugia, Italy.
    Hypertension and atrial fibrillation (AF) are 2 important public health priorities. Their prevalence is increasing worldwide, and the 2 conditions often coexist in the same patient. Hypertension and AF are strikingly related to an excess risk of cardiovascular disease and death. Read More

    Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis.
    Circ Res 2018 Jan;122(2):337-351
    From the Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester.
    Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets' role in the vasculature has led to many advances in understanding not only how platelets interact with the vessel wall but also how they convey changes in the environment to other circulating cells. Read More

    Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.
    Circ Res 2018 Jan;122(2):319-336
    From the Department of Medicine, Division of Cardiology, Birmingham Veteran Affairs Medical Center (L.J.D.), Division of Cardiovascular Disease, Department of Medicine (L.J.D.), and Department of Cell, Developmental and Integrative Biology (J.F.C.), University of Alabama at Birmingham; and Division of Surgical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (C.M.F.).
    Chymase is the most efficient Ang II (angiotensin II)-forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions. Largely thought to be the product of mast cells, the identification of other cellular sources including cardiac fibroblasts and vascular endothelial cells demonstrates a more widely dispersed production and distribution system in various tissues. Furthermore, newly emerging evidence for its intracellular presence in cardiomyocytes and smooth muscle cells opens an entirely new compartment of chymase-mediated actions that were previously thought to be limited to the extracellular space. Read More

    Translational Research in Cardiovascular Repair: A Call for a Paradigm Shift.
    Circ Res 2018 Jan;122(2):310-318
    From the Department of Cardiology (S.A.J.C., M.v.d.N., A.O.K.) and Regenerative Medicine Center Utrecht (S.A.J.C., M.v.d.N.), University Medical Center Utrecht, The Netherlands; European Society of Cardiology Working Group on Cardiovascular Regenerative and Reparative Medicine (CARE), Biot, France (S.A.J.C., A.M.C., F.F.-A.); Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV, Madrid, Spain (A.M.C., F.F.-A.); Department of Health Evidence, SYRCLE, Radboud University Medical Center, Nijmegen, The Netherlands (K.E.W.); Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands (D.J.D.); The Netherlands Heart Institute, Utrecht (D.J.D.); and Division of Cardiology, Department of Medicine, Institute of Molecular Cardiology, University of Louisville, KY (R.B.).
    The international consortium TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) has recently addressed key priorities in the field of cell-based therapy for cardiac repair, identifying the efficacy of translational research as one of the main challenges to ultimately improve the quality of life of patients with ischemic disease. Much of the controversy and confusion surrounding cardiac regenerative therapy stems from insufficient rigor in the conduct of preclinical studies, and there is an increasing recognition of a number of problems that undermine its quality that may contribute to translational failure. Here, we introduce well defined stages for preclinical research, and put forth proposals that should promote more rigorous preclinical work, in an effort to improve its quality and translatability. Read More

    Reducing Cardiovascular Disparities Through Community-Engaged Implementation Research: A National Heart, Lung, and Blood Institute Workshop Report.
    Circ Res 2018 Jan;122(2):213-230
    From the Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (G.A.M., L.N.P., M.C.G.P., B.J.N., R.A.R., M.M.E.); Loyola University Medical School, Department of Public Health Sciences, Chicago, IL (R.S.C.); University of Virginia School of Nursing, Charlottesville (A.M.S.-R.); Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD (L.A.C.); Johns Hopkins Bloomberg School of Public Health, Department of Health, Behavior, and Society, Baltimore, MD (L.A.C.); Center for Prevention Implementation Methodology (Ce-PIM), Northwestern University Feinberg School of Medicine, Chicago, IL (J.D.S., C.H.B.); Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora (J.M.W.); Morehouse School of Medicine, Department of Medicine, Atlanta, GA (E.O.O.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (S.A., C.R.N., N.R., M.L.A.-S., J.P.R., C.A.P., D.C.G.); University of Mississippi Medical Center, John D. Bower School of Population Health, Jackson (B.M.B.); University of North Carolina at Chapel Hill School of Nursing (J.L.B.); Michigan State University College of Human Medicine, Department of Epidemiology and Biostatistics, East Lansing (D.F.-H.); National Human Genome Research Institute, Bethesda, MD (S.Y.G.); School of Public Health, University of Illinois at Chicago (W.H.G., K.S.W.); Office of the Director, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD (R.S.J., E.J.P.-S.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (T.T.L.); Institute for Health Metrics and Evaluation, University of Washington, Seattle (A.H.M.); Department of Neurology, University of Louisville, KY (K.D.M.); Department of Population Health, Center for Healthful Behavior Change, New York University School of Medicine, New York (J.E.R.); Community-Campus Partnerships for Health, Raleigh, NC (A.R.); UK Medical Center, University of Kentucky, Department of Medical Behavioral Science, Lexington (N.E.S.); Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center (M.S.); Office of Health Equity, Health Resources and Services Administration, Rockville, MD (G.K.S.); National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (A.E.S.); and Social and Health Research Center, San Antonio, TX (R.P.T.).
    Cardiovascular disparities remain pervasive in the United States. Unequal disease burden is evident among population groups based on sex, race, ethnicity, socioeconomic status, educational attainment, nativity, or geography. Despite the significant declines in cardiovascular disease mortality rates in all demographic groups during the last 50 years, large disparities remain by sex, race, ethnicity, and geography. Read More

    T4 Translational Moonshot: Making Cardiovascular Discoveries Work for Everyone.
    Circ Res 2018 Jan;122(2):210-212
    From the Department of Family Medicine, High Plains Research Network, Farley Health Policy Center, University of Colorado Anschutz Medical Campus, Aurora (J.M.W.); and Center for Translation Research and Implementation Science (CTRIS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland (G.A.M.).

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