17,344 results match your criteria Circulation research[Journal]


Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart.

Circ Res 2019 Apr 15. Epub 2019 Apr 15.

Cardiovascular Research Center, Temple University School of Medicine.

Rationale: Protein Kinase A (PKA) is a major mediator of β-adrenergic (βAR) regulation of cardiac function but other mediators have also been suggested. Reduced PKA basal activity and activation are linked to cardiac diseases. However, how complete loss of PKA activity impacts on cardiac physiology and if it causes cardiac dysfunction have never been determined. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313417DOI Listing
April 2019
1 Read
11.019 Impact Factor

Letter by Cristóbal et al Regarding Article, "Protein Phosphatase 2A Regulates Cardiac Na Channels".

Circ Res 2019 Apr;124(8):e59

Translational Oncology Division, Oncohealth Institute, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.31490
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http://dx.doi.org/10.1161/CIRCRESAHA.119.314905DOI Listing
April 2019
1 Read

Human Embryonic Stem Cell-Derived Cardiomyocytes.

Circ Res 2019 Apr;124(8):1157-1159

From the Institute of Molecular Cardiology, University of Louisville, KY.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314869DOI Listing

Inflammation and Its Role in Regeneration and Repair.

Authors:
John P Cooke

Circ Res 2019 Apr;124(8):1166-1168

From the Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314669DOI Listing

Contrasting Effects on Mortality of Monounsaturated Fatty Acid Intake Depending on Vegetable or Animal Sources.

Authors:
Emilio Ros

Circ Res 2019 Apr;124(8):1154-1156

From the Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain; and CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314842DOI Listing

Meet the First Author.

Authors:

Circ Res 2019 Apr;124(8):1142-1145

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http://dx.doi.org/10.1161/RES.0000000000000269DOI Listing

High-Throughput Contractility Assay for Human Stem Cell-Derived Cardiomyocytes.

Circ Res 2019 Apr;124(8):1146-1148

From the Department of Bioengineering (J.W.M., D.-H.K.), University of Washington, Seattle.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461366PMC

Maintaining Matrix Composure Under Stress.

Circ Res 2019 Apr;124(8):1149-1150

From the Departments of Medicine and Pathology, University of Washington School of Medicine, Seattle.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314843DOI Listing

Diabetic Cardiomyopathy.

Circ Res 2019 Apr;124(8):1160-1162

From the Division of Endocrinology/Metabolism, Department of Medicine, University of California, San Diego, La Jolla.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31466
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314665DOI Listing
April 2019
1 Read

Response by El Refaey et al to Letter Regarding Article, "Protein Phosphatase 2A Regulates Cardiac Na Channels".

Circ Res 2019 Apr;124(8):e60-e61

The Dorothy M. Davis Heart & Lung Research Institute, The Frick Center for Heart Failure and Arrhythmia, Department of Internal Medicine, Department of Physiology and Cell Biology, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314938DOI Listing
April 2019
5 Reads

Endothelial-to-Mesenchymal Transition.

Authors:
Joyce Bischoff

Circ Res 2019 Apr;124(8):1163-1165

From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Department of Surgery, Harvard Medical School, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314813DOI Listing

Sarcomere-Directed Calcium Reporters in Cardiomyocytes.

Circ Res 2019 Apr;124(8):1151-1153

The Jackson Laboratory for Genomic Medicine, Farmington, CT (J.T.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314877DOI Listing

William Harvey and the Discovery of the Circulation of the Blood.

Authors:
Roberto Bolli

Circ Res 2019 Apr;124(8):1169-1171

From the Institute of Molecular Cardiology, University of Louisville, KY.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.31497
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http://dx.doi.org/10.1161/CIRCRESAHA.119.314976DOI Listing
April 2019
1 Read

Letter by Lou and Zhou Regarding Article, "NHLBI-Sponsored Randomized Trial of Postconditioning During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction".

Circ Res 2019 Apr;124(8):e55-e56

Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314734DOI Listing
April 2019
2 Reads

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study.

Circ Res 2019 Apr 11. Epub 2019 Apr 11.

Genetics, University Medical Center Groningen.

Rationale: Altered gut microbial composition has been linked to cardiovascular diseases (CVD), but its functional links to host metabolism and immunity in relation to CVD development remain unclear.

Objective: To systematically assess functional links between the microbiome and the plasma metabolome, cardiometabolic phenotypes and CVD risk and to identify diet-microbe-metabolism-immune interactions in well-documented cohorts.

Methods And Results: We assessed metagenomics-based microbial associations between 231 plasma metabolites and microbial species and pathways in the population-based Lifelines-DEEP cohort (n=978) and a clinical obesity cohort (n=297). Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314642DOI Listing
April 2019
2 Reads

Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury.

Circ Res 2019 Apr 9. Epub 2019 Apr 9.

Center for Metabolic Disease Research, Temple University School of Medicine.

Rationale: Embryonic heart is characterized by of rapidly dividing cardiomyocytes required to build a working myocardium. Cardiomyocytes retain some proliferative capacity in the neonates but lose it in adulthood. Consequently, a number of signaling hubs including microRNAs are altered during cardiac development that adversely impacts regenerative potential of cardiac tissue. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314223DOI Listing
April 2019
1 Read
11.019 Impact Factor

Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid Hemorrhage.

Circ Res 2019 Apr 5. Epub 2019 Apr 5.

Hans Berger Department of Neurology, University Hospital Jena.

Rationale: Delayed ischemic neurological deficit is the most common cause of neurological impairment and unfavorable prognosis in subarachnoid hemorrhage (SAH) patients. Despite the existence of neuroimaging modalities that depict the onset of the accompanying cerebral vasospasm, preventive and therapeutic options are limited and fail to improve outcome owing to an insufficient pathomechanistic understanding of the delayed perfusion deficit. Previous studies have suggested that bilirubin oxidation products (BOXes), originating from released heme surrounding ruptured blood vessels, are involved in arterial vasoconstriction. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314160DOI Listing
April 2019
4 Reads

CRRL269: A Novel Particulate Guanylyl Cyclase A Receptor Peptide Activator For Acute Kidney Injury.

Circ Res 2019 Apr 1. Epub 2019 Apr 1.

Cardiorenal Research Laboratory, Mayo Clinic.

Rationale: Acute kidney injury (AKI) has a high prevalence and mortality in critically ill patients. It is also a powerful risk factor for heart failure (HF) incidence driven by hemodynamic changes and neurohormonal activation. However, no drugs have been approved by the FDA. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314164DOI Listing
April 2019
2 Reads

Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease.

Circ Res 2019 Apr 1. Epub 2019 Apr 1.

Nephrology, Technical University of Munich.

Rationale: Patients with end-stage renal disease (ESRD) are characterized by increased cardiovascular (CV) and all-cause mortality due to advanced remodeling of the macro- and microvascular beds.

Objective: The aim of this study was to determine whether retinal microvascular function can predict all-cause and CV mortality in patients with ESRD.

Methods And Results: In the multicenter prospective observational ISAR (Risk Stratification in End-Stage Renal Disease) study, data on dynamic retinal vessel analysis (DVA) was available in a sub-cohort of 214 dialysis patients (mean age 62. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314318DOI Listing
April 2019
1 Read
11.019 Impact Factor

Combined Intrahospital Remote Ischemic Perconditioning and Postconditioning Improves Clinical Outcome in ST-Elevation Myocardial Infarction: Long-Term Results of the LIPSIA CONDITIONING Trial.

Circ Res 2019 Apr 1. Epub 2019 Apr 1.

Medical Clinic II, University Heart Center Lübeck.

Rationale: Remote ischemic conditioning (RIC) and/or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-elevation myocardial infarction (STEMI).

Objective: To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneous coronary intervention (PCI) reduce long-term clinical events after STEMI.

Methods And Results: The present study is a post-hoc analysis of a prospective trial which randomized 696 STEMI patients with symptoms <12 hours 1:1:1 to either combined RIC and PostC in addition to primary PCI, PostC alone in addition to primary PCI, or conventional PCI (control). Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314500DOI Listing

Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Circ Res 2019 Mar 29. Epub 2019 Mar 29.

Medicine, Queen's University.

Rationale: Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMC). Hypoxia dilates systemic arteries, including renal arteries. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31428
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314284DOI Listing
March 2019
2 Reads

Impact of Cell Therapy on Cardiovascular Outcomes in Patients With Refractory Angina: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Circ Res 2019 Mar 29. Epub 2019 Mar 29.

Cardiology, Barts Heart Centre.

Rationale: Cell based therapies are a novel potential treatment for refractory angina (RFA) and have been found to improve markers of angina. However, the effects on mortality and major adverse cardiac events (MACE) have not been definitively investigated.

Objective: To investigate the efficacy and safety of stem cell treatment compared with optimal medical treatment (OMT) for RFA by conducting an updated meta-analysis, looking at clinical outcomes. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31411
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314118DOI Listing
March 2019
1 Read

New Blood Pressure Guidelines Pose Difficult Choices for Australian Physicians.

Circ Res 2019 Mar;124(7):975-977

the Professorial Unit (J.C.), The George Institute for Global Health, University of NSW, Sydney, Australia.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314637DOI Listing

Blood Pressure Measurement and Treatment Decisions.

Circ Res 2019 Mar;124(7):990-1008

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (L.T., J.A.S.).

White-coat and masked hypertension are important hypertension phenotypes. Out-of-office blood pressure measurement is essential for the accurate diagnosis and monitoring of these conditions. This review summarizes literature related to the detection and diagnosis, prevalence, epidemiology, prognosis, and treatment of white-coat and masked hypertension. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313219DOI Listing

Implications of Guidelines for Hypertension Management in Europe.

Circ Res 2019 Mar;124(7):972-974

From the Department of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Italy (M.V., G.G., A.B., G.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314724DOI Listing
March 2019
11.019 Impact Factor

Two-Drug Combinations as First-Step Antihypertensive Treatment.

Circ Res 2019 Mar;124(7):1113-1123

Department of Medicine and Surgery Clinica Medica (G.G.), University of Milano-Bicocca, Italy.

Blood pressure (BP) control in patients with hypertension is variable worldwide, and in general, it results largely unsatisfactory. Factors responsible for this phenomenon include insufficient national cardiovascular healthcare policies for prevention, poor patient compliance with prescribed treatment schedules, and the reluctance of physicians to modify treatment strategies when BP is still elevated, that is, the so-called therapeutic inertia. A further important factor favoring poor BP control is the limited use of combination drug treatment, despite evidence of its superior ability to control BP in patients with difficult-to-treat hypertension. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313294DOI Listing

Neurovascular and Cognitive Dysfunction in Hypertension.

Circ Res 2019 Mar;124(7):1025-1044

Departments of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD.

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people. Thus, although midlife hypertension is a risk factor for late-life dementia, hypertension may also promote the neurodegenerative pathology underlying Alzheimer disease. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313260DOI Listing
March 2019
1 Read

Hypertension Management in Older and Frail Older Patients.

Circ Res 2019 Mar;124(7):1045-1060

University of Helsinki, Clinicum, and Helsinki University Hospital, Finland (T.S.).

The prevalence of arterial hypertension, particularly systolic hypertension, is constantly rising worldwide. This is mainly the clinical expression of arterial stiffening as a result of the population's aging. Chronic elevation in blood pressure represents a major risk factor not only for cardiovascular morbidity and mortality but also for cognitive decline and loss of autonomy later in life. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313236DOI Listing
March 2019
1 Read

Recent Guidelines for Hypertension.

Circ Res 2019 Mar;124(7):984-986

World Hypertension League/South Asia Office, Apollo Hospitals, and Apollo Medical College, Hyderabad, India (C.V.S.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314789DOI Listing
March 2019
1 Read

Similarities and Differences Between the ACC/AHA and ESH/ESC Guidelines for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.

Authors:
George Bakris

Circ Res 2019 Mar;124(7):969-971

From the Department of Medicine, AHA Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, University of Chicago Medicine, IL.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314664DOI Listing

Introduction to a Compendium on the Pathophysiology and Treatment of Hypertension.

Circ Res 2019 Mar;124(7):967-968

Department of Physiology and Biophysics and Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson (J.E.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314953DOI Listing
March 2019
1 Read

Treatment of Resistant and Refractory Hypertension.

Circ Res 2019 Mar;124(7):1061-1070

From the Department of Medicine, Division of Cardiovascular Disease, Vascular Biology and Hypertension Program, University of Alabama at Birmingham.

Resistant hypertension (RHTN) is defined as uncontrolled blood pressure despite the use of ≥3 antihypertensive agents of different classes, including a diuretic, usually thiazide-like, a long-acting calcium channel blocker, and a blocker of the renin- angiotensin system, either an ACE (angiotensin-converting enzyme) inhibitor or an ARB (angiotensin receptor blocker), at maximal or maximally tolerated doses. Antihypertensive medication nonadherence and the white coat effect, defined as elevated blood pressure when measured in clinic but controlled when measured outside of clinic, must be excluded to make the diagnosis. RHTN is a high-risk phenotype, leading to increased all-cause mortality and cardiovascular disease outcomes. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469348PMC

Precision Medicine.

Authors:
Joseph Loscalzo

Circ Res 2019 Mar;124(7):987-989

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314403DOI Listing

Comments on 2018 ESC/ESH Hypertension Guidelines: Chinese Perspective.

Circ Res 2019 Mar;124(7):978-980

From the Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Y.Z., L.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314997DOI Listing

Viewpoint on Guidelines for Treatment of Hypertension in Japan.

Circ Res 2019 Mar;124(7):981-983

Tohoku University Graduate School of Medicine, Sendai, Japan (S.I.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314991DOI Listing

Metabolic Surgery for Hypertension in Patients With Obesity.

Circ Res 2019 Mar;124(7):1009-1024

Bariatric and Metabolic Institute, Cleveland Clinic, OH (P.R.S.).

The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most research has been directed toward the glycemic effects of weight loss surgery, there has been a growing interest in exploring its potential blood pressure-reducing properties. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31332
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313320DOI Listing
March 2019
1 Read

Device-Based Neuromodulation for Resistant Hypertension Therapy.

Circ Res 2019 Mar;124(7):1071-1093

From the Department of Physiology and Biophysics (T.E.L., J.E.H.), University of Mississippi Medical Center, Jackson.

Despite availability of effective drugs for hypertension therapy, significant numbers of hypertensive patients fail to achieve recommended blood pressure levels on ≥3 antihypertensive drugs of different classes. These individuals have a high prevalence of adverse cardiovascular events and are defined as having resistant hypertension (RHT) although nonadherence to prescribed antihypertensive medications is common in patients with apparent RHT. Furthermore, apparent and true RHT often display increased sympathetic activity. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442942PMC

Preeclampsia.

Circ Res 2019 Mar;124(7):1094-1112

Departments of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (S.A.K.).

Hypertensive disorders of pregnancy-chronic hypertension, gestational hypertension, and preeclampsia-are uniquely challenging as the pathology and its therapeutic management simultaneously affect mother and fetus, sometimes putting their well-being at odds with each other. Preeclampsia, in particular, is one of the most feared complications of pregnancy. Often presenting as new-onset hypertension and proteinuria during the third trimester, preeclampsia can progress rapidly to serious complications, including death of both mother and fetus. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313276DOI Listing
March 2019
2 Reads

Adherence in Hypertension.

Circ Res 2019 Mar;124(7):1124-1140

Department of Medicine, Care Coordination Institute, University of South Carolina School of Medicine, Greenville, SC (B.M.E.).

The global epidemic of hypertension is largely uncontrolled and hypertension remains the leading cause of noncommunicable disease deaths worldwide. Suboptimal adherence, which includes failure to initiate pharmacotherapy, to take medications as often as prescribed, and to persist on therapy long-term, is a well-recognized factor contributing to the poor control of blood pressure in hypertension. Several categories of factors including demographic, socioeconomic, concomitant medical-behavioral conditions, therapy-related, healthcare team and system-related factors, and patient factors are associated with nonadherence. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313220DOI Listing

Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury.

Circ Res 2019 Mar 27. Epub 2019 Mar 27.

Institute of Pharmacology and Clinical Pharmacology, Heinrich-Heine-University Düsseldorf.

Rationale: Immediate changes in the extracellular matrix (ECM) microenvironment occur after myocardial ischemia and reperfusion injury (I/R).

Objective: Aim of this study was to unravel the role of the early hyaluronan (HA)-rich ECM after I/R.

Methods And Results: Genetic deletion of HA synthase 2 (Has2) and Has1 were used in a murine model of cardiac I/R. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31328
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313285DOI Listing
March 2019
10 Reads

Heterocellular Contact Can Dictate Arterial Function.

Circ Res 2019 Mar 22. Epub 2019 Mar 22.

Molecular Physiology and Biological Physics, University of Virginia School of Medicine.

Rationale: Resistance arteries and conduit arteries rely upon different relative contributions of endothelial derived hyperpolarization (EDH) versus nitric oxide (NO) to achieve dilatory heterocellular signaling. Anatomically, resistance arteries use myoendothelial junctions (MEJs), endothelial cell (EC) projections that make contact with smooth muscle cells (SMCs). Conduit arteries have very few to no MEJs. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313926DOI Listing
March 2019
1 Read
11.019 Impact Factor

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.

Circ Res 2019 Mar 21. Epub 2019 Mar 21.

Pharmacology, Shandong University School of Basic Medical Science.

Rationale: Endothelial dysfunction is an important determinant risk factor for the development of hypertension and its complications. Thus, identification of potential therapeutic targets for preventing endothelial dysfunction has major clinical importance. Emerging evidence indicates that epigenetic modifications are closely associated with the regulation of endothelial function. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314032DOI Listing
March 2019
2 Reads
11.019 Impact Factor

The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program.

Circ Res 2019 Mar 20. Epub 2019 Mar 20.

National Heart and Lung Institute, Vascular Sciences, Imperial College London.

Rationale: The ETS transcription factor (TF) ERG is essential for endothelial homeostasis, driving expression of lineage genes and repressing pro-inflammatory genes. Loss of ERG expression is associated with diseases including atherosclerosis. ERG's homeostatic function is lineage-specific, since aberrant ERG expression in cancer is oncogenic. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31378
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313788DOI Listing
March 2019
1 Read

Prostate-Specific Antigen Within the Reference Range, Subclinical Coronary Atherosclerosis, and Cardiovascular Mortality: A Cohort Study.

Circ Res 2019 Mar 19. Epub 2019 Mar 19.

Occupational and Environmental Medicine, Kangbuk Samsung Hospital.

Rationale: Although prostate-specific antigen (PSA), a tumor marker for prostate cancer, has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited.

Objective: We examined the association of total serum PSA within the reference range with coronary artery calcium (CAC) score and CVD mortality.

Methods And Results: A cross-sectional study was performed in 88,203 Korean men who underwent a health checkup exam including cardiac tomography estimation of CAC score. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313413DOI Listing
March 2019
1 Read
11.019 Impact Factor

Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling.

Circ Res 2019 Mar 18. Epub 2019 Mar 18.

School of Cardiovascular Medicine and Sciences, King's College London BHF Centre.

Rationale: RNA helicases, highly conserved enzymes, are currently believed to be not only involved in RNA modulation, but also in other biological processes. We recently reported that RNA helicase DEAD-box protein 5 (DDX5) is required for maintaining the homeostasis of vascular smooth muscle cells (SMCs). However, the expression and function of RNA helicase in vascular physiology and disease is unknown. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314062DOI Listing
March 2019
3 Reads

Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection.

Circ Res 2019 Mar 18. Epub 2019 Mar 18.

School of Aerospace Medicine, Fourth Military Medical University.

Rationale: Exercise training, in addition to reducing cardiovascular risk factors, confers direct protection against myocardial ischemia/reperfusion (MI/R) injury and has been associated with improved heart-attack survival in humans. However, the underlying mechanisms of exercise-afforded cardioprotection are still unclear.

Objective: To investigate the role of exercise-derived circulating exosomes in cardioprotection and the molecular mechanisms involved. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314635DOI Listing
March 2019
2 Reads
11.019 Impact Factor

Clinical Translation of Stem Cells for Regenerative Medicine.

Authors:
Deepa Bhartiya

Circ Res 2019 03;124(6):840-842

From the Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313823DOI Listing
March 2019
1 Read

Precision Medicine in Pulmonary Arterial Hypertension.

Circ Res 2019 Mar;124(6):832-833

From the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419751PMC
March 2019
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