17,265 results match your criteria Circulation research[Journal]


Precision Versus Traditional Medicine-Clinical Questions Trigger Progress in Basic Science.

Circ Res 2019 Feb;124(4):459-461

Laboratory of Cardiovascular Genetics (P.J.S., L.S.), Milan, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314629DOI Listing
February 2019

2018 BCVS Honorees: Louis N. and Arnold M. Katz Basic Research Prize.

Authors:

Circ Res 2019 Feb;124(4):477-480

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http://dx.doi.org/10.1161/RES.0000000000000260DOI Listing
February 2019

Meet the First Authors.

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Circ Res 2019 Feb;124(4):452-455

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http://dx.doi.org/10.1161/RES.0000000000000261DOI Listing
February 2019

Introduction to the Compendium on Aortic Aneurysms.

Circ Res 2019 Feb;124(4):470-471

From the Division of Cardiology, Department of Medicine (R.A.Q., W.R.T.), Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314765DOI Listing
February 2019

Michelle Parvatiyar.

Circ Res 2019 Feb;124(4):475-476

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314764DOI Listing
February 2019

Circular RNA Control of Vascular Smooth Muscle Cell Functions.

Circ Res 2019 Feb;124(4):456-458

From the Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314521DOI Listing
February 2019

Another Notch in the Genetic Puzzle of Tetralogy of Fallot.

Circ Res 2019 Feb;124(4):462-464

From the Center for Cardiovascular Research and Heart Center, Nationwide Children's Hospital, Columbus, OH (A.M.-N., J.Y., V.G.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314520DOI Listing
February 2019

Pharmacologic Management of Aneurysms.

Circ Res 2019 Feb;124(4):631-646

Division of Vascular Surgery, School of Medicine and Public Health, University of Wisconsin, Madison (J.S.M.).

Current management of aortic aneurysms relies exclusively on prophylactic operative repair of larger aneurysms. Great potential exists for successful medical therapy that halts or reduces aneurysm progression and hence alleviates or postpones the need for surgical repair. Preclinical studies in the context of abdominal aortic aneurysm identified hundreds of candidate strategies for stabilization, and data from preoperative clinical intervention studies show that interventions in the pathways of the activated inflammatory and proteolytic cascades in enlarging abdominal aortic aneurysm are feasible. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312439DOI Listing
February 2019

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.

Circ Res 2019 Feb;124(4):619-630

From the Wallace H. Coulter Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta (S.K., H.J.).

Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312438DOI Listing
February 2019

Genetics of Thoracic and Abdominal Aortic Diseases.

Circ Res 2019 Feb;124(4):588-606

From the Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School; University of Texas Health Science Center at Houston (A.P., D.M.M.).

Dissections or ruptures of aortic aneurysms remain a leading cause of death in the developed world, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Genetic variants predispose individuals to these aortic diseases. In the case of thoracic aortic aneurysm and dissections (thoracic aortic disease), genetic data can be used to identify some at-risk individuals and dictate management of the associated vascular disease. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312436DOI Listing
February 2019

Cardiovascular Physio-Pathology by Leonardo Da Vinci (1452-1519).

Circ Res 2019 Feb;124(4):472-474

From the Policlinico Umberto I, University of Rome Sapienza, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314390DOI Listing
February 2019

Leducq Transatlantic Network on Clonal Hematopoiesis and Atherosclerosis.

Circ Res 2019 Feb;124(4):481-483

Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY (A.R.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314677DOI Listing
February 2019

Cardiovascular Leaders Are Made, not Born.

Circ Res 2019 Feb;124(4):484-487

From the Heart, Lung and Vascular Institute and Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314611DOI Listing
February 2019

Concept Framework of Vaccines-Like Administration to Preatherosclerosis.

Authors:
Yue Zheng Tong Li

Circ Res 2019 Feb;124(4):488-490

Department of Cardiology, Third Central Hospital of Tianjin, China (T.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314633DOI Listing
February 2019

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.

Circ Res 2019 Feb;124(4):467-469

From the Center for Interdisciplinary Cardiovascular Sciences (M.C.B., E.A.), Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314596DOI Listing
February 2019

Depression Depresses Vasodilation.

Authors:
Michael J Joyner

Circ Res 2019 Feb;124(4):465-466

From the Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, MN 55905.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314595DOI Listing
February 2019

Cellular Mechanisms of Aortic Aneurysm Formation.

Circ Res 2019 Feb;124(4):607-618

From the Division of Cardiology, Department of Medicine (R.A.Q., W.R.T.), Emory University School of Medicine, Atlanta, GA.

Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the United States annually. Although thoracic and abdominal aortic aneurysms share some common characteristics, including the gross anatomic appearance, alterations in extracellular matrix, and loss of smooth muscle cells, they are distinct diseases. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313187DOI Listing
February 2019

Open and Endovascular Management of Aortic Aneurysms.

Circ Res 2019 Feb;124(4):647-661

From the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Aneurysmal disease can affect any segment of the aorta, from the aortic root to the aortic bifurcation. The treatment of aortic aneurysms has evolved dramatically in the past 3 decades, with the introduction of endovascular aneurysm repair using stent grafts causing a major paradigm shift in the field of aortic aneurysm surgery. While the technical details of the management of aortic aneurysms vary greatly depending on the location of an aneurysm, the principles remain the same. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313186DOI Listing
February 2019

Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair: Implications for Stimulating Neomyogenesis with Cell-Based Therapy.

Circ Res 2019 Feb 12. Epub 2019 Feb 12.

Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, UNITED STATES.

Rationale: Although rare cardiomyogenesis is reported in the adult mammalian heart, whether this results from differentiation or proliferation of cardiomyogenic cells remains controversial. The tumor suppressor genes RB1 and CDKN2a are critical cell-cycle regulators, but their roles in human cardiomyogenesis remains unclear.

Objective: We hypothesized that developmental activation of RB1 and CDKN2a cooperatively cause permanent cell-cycle withdrawal of human cardiac precursors (CPCs) driving terminal differentiation into mature cardiomyocytes (CM), and that dual inactivation of these tumor suppressor genes promotes myocyte cell-cycle re-entry. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314063DOI Listing
February 2019

Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes is Associated with Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.

Circ Res 2019 Feb 11. Epub 2019 Feb 11.

Center for Cardiovascular Genetics, The University of Texas Health Sciences Center at Houston.

Rationale: Lamin A/C (LMNA), a nuclear membrane protein, interacts with genome through lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA gene cause a diverse array of diseases, including dilated cardiomyopathy (DCM). DCM is the leading cause of death in laminopathies. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314177DOI Listing
February 2019
1 Read

Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury.

Circ Res 2019 Feb 11. Epub 2019 Feb 11.

Surgery, University of Wisconsin School of Medicine and Public Health.

Rationale: Regeneration of denuded or injured endothelium is an important component of vascular injury response. Cell-cell communication between endothelial cells (ECs) and smooth muscle cells (SMCs) plays a critical role not only in vascular homeostasis but also in disease. We have previously demonstrated that protein kinase C-delta (PKCδ) regulates multiple components of vascular injury response including apoptosis of SMCs and production of chemokines, thus is an attractive candidate for a role in SMC-EC communication. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314567DOI Listing
February 2019

Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction.

Circ Res 2019 Feb 8. Epub 2019 Feb 8.

Chemistry, University of Florence.

Rationale: Despite major advances in cardiovascular medicine, heart disease remains a leading cause of death worldwide. However, the field of tissue engineering has been growing exponentially in the last decade and restoring heart functionality is now an affordable target; yet, new materials are still needed for effectively provide rapid and long-lasting interventions. Liquid Crystalline Elastomers (LCEs) are biocompatible polymers able to reversibly change shape in response to a given stimulus, and generate movement. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31388
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313889DOI Listing
February 2019
1 Read

Measurement of Myofilament-Localised Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.

Circ Res 2019 Feb 8. Epub 2019 Feb 8.

Cardiovascular Medicine, University of Oxford.

Rationale: Subcellular Ca indicators have yet to be developed for the myofilament where disease mutation, or small molecules may alter contractility through myofilament Ca sensitivity. Here we develop and characterise genetically encoded Ca indicators restricted to the myofilament to directly visualise Ca2 changes in the sarcomere.

Objective: To produce and validate myofilament restricted Ca imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil and levosimendan) or following co-transduction of two established hypertrophic cardiomyopathy (HCM) disease causing mutants (cTnT R92Q and cTnI R145G) that alter myofilament Ca handling. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314600DOI Listing
February 2019

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.

Circ Res 2019 Feb 8. Epub 2019 Feb 8.

Immunology, Genetics, and Pathology, Uppsala University.

Rationale: Aberrant formation of blood vessels precedes a broad spectrum of vascular complications, however, the cellular and molecular events governing vascular malformations are not yet fully understood.

Objective: Here, we investigated the role of CDC42 during vascular morphogenesis and its relative importance for the development of cerebrovascular malformations.

Methods And Results: In order to avoid secondary systemic effects often associated with embryonic gene deletion we generated an endothelial-specific and inducible knockout approach to study postnatal vascularization of the mouse brain. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31430
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314300DOI Listing
February 2019
2 Reads
11.019 Impact Factor

High-Risk Human Papillomavirus Infection and the Risk of Cardiovascular Disease in Korean Women: A Cohort Study.

Circ Res 2019 Feb 7. Epub 2019 Feb 7.

Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.

Rationale: Until now, no cohort studies have evaluated the relationship between high-risk human papillomavirus (HPV) infection and new-onset cardiovascular diseases (CVD).

Objective: We investigated an association between high-risk HPV infection and the development of CVD.

Methods And Results: We conducted a cohort study of 63,411 women aged 30 or older without CVD at baseline who underwent a high-risk HPV test and were followed annually or biennially from 2011 to 2016. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313779DOI Listing
February 2019

Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development.

Circ Res 2019 Feb 1. Epub 2019 Feb 1.

Comparative Medicine, Yale University School of Medicine.

Rationale: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient mice are predisposed to the development of obesity and metabolic dysfunction. The pro-atherogenic effects of miR-33 are thought to be in large part due to its repression of macrophage cholesterol efflux, through targeting of ATP Binding Cassette Subfamily A Member 1 ( Abca1). However, targeting of other factors may also be required for the beneficial effects of miR-33 and currently available approaches have not allowed researchers to determine the specific impact of individual miRNA target interactions in vivo. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314415DOI Listing
February 2019

Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function.

Circ Res 2019 Feb 1. Epub 2019 Feb 1.

Pediatrics, Emory University.

Rationale: Endothelial barrier function depends on the proper localization and function of the adherens junction protein VE-cadherin. Previous studies have suggested a functional relationship between integrin-mediated adhesion complexes and VE-cadherin yet the underlying molecular links are unclear. Binding of the cytoskeletal adaptor protein talin to the β integrin cytoplasmic domain is a key final step in regulating the affinity of integrins for extracellular ligands (activation) but the role of integrin activation in VE-cadherin mediated endothelial barrier function is unknown. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314560DOI Listing
February 2019

Synergy of Dual Pathway Inhibition in Chronic Cardiovascular Disease.

Circ Res 2019 Feb;124(3):416-425

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.I.W., J.W.A.E.).

Although acetylsalicylic acid is of proven benefit for secondary prevention in patients with cardiovascular disease, the risk of recurrent ischemic events remains high. Intensification of antithrombotic therapy with more potent antiplatelet drugs, dual antiplatelet therapy, or vitamin K antagonists further reduces the risk of major adverse cardiovascular events compared with acetylsalicylic acid alone but increases the risk of bleeding without reducing mortality. In patients with prior coronary artery disease or peripheral arterial disease the COMPASS (Cardiovascular Outcomes for People Using Anticoagulation Strategies) trial revealed that compared with acetylsalicylic acid alone, dual pathway inhibition with low-dose rivaroxaban (2. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313141DOI Listing
February 2019
1 Read

Lipid-Lowering Agents.

Circ Res 2019 Feb;124(3):386-404

Sulpizio Cardiovascular Center, Vascular Medicine Program, University of California San Diego, La Jolla (S.T.).

Several new or emerging drugs for dyslipidemia owe their existence, in part, to human genetic evidence, such as observations in families with rare genetic disorders or in Mendelian randomization studies. Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipoprotein[a]), with some sustained programs on agents to raise HDL (high-density lipoprotein) cholesterol. Lomitapide, mipomersen, AAV8. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313171DOI Listing
February 2019

Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis

Authors:
Paul M Ridker

Circ Res 2019 02;124(3):437-450

From the Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Medicine and Preventive Medicine, Brigham and Women's Hospital, Boston, MA.

The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated through both adaptive and innate immunity has led to the hypothesis that anticytokine therapies targeting specific IL (interleukin) signaling pathways could serve as powerful adjuncts to lipid lowering in the prevention and treatment of cardiovascular disease. Cytokines involved in human atherosclerosis can be broadly classified as proinflammatory and proatherogenic (such as IL-1, IL-6, and TNF [tumor necrosis factor]) or as anti-inflammatory and antiatherogenic (such as IL-10 and IL-1rA). The recent CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study) has shown that specific targeting of IL-1β can significantly reduce cardiovascular event rates without lipid or blood pressure lowering. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313129DOI Listing
February 2019

Cholesterol-Lowering Agents.

Circ Res 2019 Feb;124(3):364-385

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (W.K.).

Loss-of-function variants in PCSK9 (proprotein convertase subtilisin-kexin type 9) are associated with lower lifetime risk of atherosclerotic cardiovascular disease) events. Confirmation of these genetic observations in large, prospective clinical trials in participants with atherosclerotic cardiovascular disease has provided guidance on risk stratification and enhanced our knowledge on hitherto unresolved and contentious issues concerning the efficacy and safety of markedly lowering LDL-C (low-density lipoprotein cholesterol). PCSK9 has a broad repertoire of molecular effects. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313238DOI Listing
February 2019
1 Read

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circ Res 2019 Feb;124(3):405-415

From the Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla.

The prevalence of calcific aortic valve disease is increasing with aging of the population. Current treatment options for advanced or symptomatic aortic stenosis are limited to traditional surgical or percutaneous aortic valve replacement. Medical therapies that impact the progression of calcific aortic valve disease do not currently exist. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361547PMC
February 2019
2 Reads

Overview of Therapeutic Approaches for Cholesterol Lowering and Attenuation of Thrombosis for Prevention of Atherothrombosis.

Circ Res 2019 Feb;124(3):351-353

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland (S.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314576DOI Listing
February 2019

Cholesterol-Lowering Agents.

Circ Res 2019 Feb;124(3):354-363

From the Department of Primary Care and Public Health, Imperial College, London, United Kingdom.

Cardiovascular disease (CVD) remains the leading cause of death worldwide. To date, decades of research has established LDL-C (low-density lipoprotein cholesterol) as a causal factor in the development of atherosclerotic CVD. Statin therapy, supported by a broad evidence base, has demonstrated its superior efficacy in reducing LDL-C and subsequent cardiovascular risk. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313245DOI Listing
February 2019
1 Read

Antithrombotic Agents.

Circ Res 2019 Feb;124(3):426-436

From the Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Recent advances in our understanding of the contribution of thrombin generation to arterial thrombosis and the role of platelets in venous thrombosis have prompted new treatment paradigms. Nonetheless, bleeding remains the major side effect of such treatments spurring the quest for new antithrombotic regimens with better benefit-risk profiles and for safer anticoagulants for existing and new indications. The aims of this article are to review the results of recent trials aimed at enhancing the benefit-risk profile of antithrombotic therapy and explain how these findings are changing our approach to the management of arterial and venous thrombosis. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313155DOI Listing
February 2019
7 Reads

SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes.

Circ Res 2019 Jan 31. Epub 2019 Jan 31.

Genetics, Harvard Medical School, UNITED STATES.

Rationale: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in combination with CRISPR/Cas9 genome editing provide unparalleled opportunities to study cardiac biology and disease. However, sarcomeres, the fundamental units of myocyte contraction, are immature and nonlinear in hiPSC-CMs, which technically challenges accurate functional interrogation of contractile parameters in beating cells. Furthermore, existing analysis methods are relatively low-throughput, indirectly assess contractility, or only assess well-aligned sarcomeres found in mature cardiac tissues. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
January 2019
1 Read

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated with Lamin A/C Mutations.

Circ Res 2019 Jan 30. Epub 2019 Jan 30.

Center for Cardiovascular Genetics, University of Texas Health Sciences Center at Houston.

Rationale: Mutations in the LMNA gene, encoding lamin A/C (LMNA), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies.

Objective: To gain insights into the molecular pathogenesis of DCM in laminopathies. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31423
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314238DOI Listing
January 2019
12 Reads

Associations of Monounsaturated Fatty Acids from Plant and Animal Sources with Total and Cause-Specific Mortality in Two US Prospective Cohort Studies.

Circ Res 2019 Jan 28. Epub 2019 Jan 28.

Channing Division of Network Medicine, Brigham and Women's Hospital.

Rationale: Dietary monounsaturated fatty acids (MUFAs) can come from both plant and animal sources with divergent nutrient profiles that may potentially obscure the associations of total MUFAs with chronic diseases.

Objective: To investigate the associations of cis-MUFA intake from plant (MUFA-P) and animal (MUFA-A) sources with total and cause-specific mortality.

Methods And Results: We followed 63,412 women from the Nurses' Health Study (1990-2012) and 29,966 men from the Health Professionals Follow-Up Study (1990-2012). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31399
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313996DOI Listing
January 2019
2 Reads

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program.

Circ Res 2019 Jan 28. Epub 2019 Jan 28.

The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine.

Rationale: The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors and neurohumoral mediators stimulate fibroblast activation, inducing extracellular matrix protein synthesis, and promoting fibrosis and diastolic dysfunction. Members of the Transforming Growth Factor (TGF)-β family are upregulated and activated in the remodeling myocardium and modulate phenotype and function of all myocardial cell types through activation of intracellular effector molecules, the Smads, and through Smad-independent pathways. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314438DOI Listing
January 2019
1 Read

Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.

Circ Res 2019 Jan 21. Epub 2019 Jan 21.

Pulmonary and Critical Care Medicine, Stanford University.

Rationale: Accumulating evidence implicates inflammation in pulmonary arterial hypertension (PAH) and therapies targeting immunity are under investigation, though it remains unknown if distinct immune phenotypes exist.

Objective: Identify PAH immune phenotypes based on unsupervised analysis of blood proteomic profiles.

Methods And Results: In a prospective observational study of Group 1 PAH patients evaluated at Stanford University (discovery cohort, n=281) and University of Sheffield (validation cohort, n=104) between 2008-2014, we measured a circulating proteomic panel of 48 cytokines, chemokines, and factors using multiplex immunoassay. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31391
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313911DOI Listing
January 2019
3 Reads

Extreme Levels of Air Pollution Associated with Changes in Biomarkers of Atherosclerotic Plaque Vulnerability and Thrombogenicity in Healthy Adults: The Beijing AIRCHD Study.

Circ Res 2019 Jan 21. Epub 2019 Jan 21.

Occupational and Environmental Health, Peking University School of Public Health, CHINA.

Rationale: The pathophysiologic mechanisms of air pollution associated exacerbation of cardiovascular events remain incompletely understood.

Objective: To assess whether ambient air pollution can be a trigger of the vulnerable plaque and heightened thrombogenicity through systemic inflammatory pathways.

Methods And Results: In Beijing AIRCHD study, seventy-three healthy adults (mean {plus minus} standard deviation, 23. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31394
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313948DOI Listing
January 2019
6 Reads
11.019 Impact Factor

Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart.

Circ Res 2019 Jan 21. Epub 2019 Jan 21.

Center for Cardiovascular Research, Washington University School of Medicine.

Rationale: Paradigm shifting studies have revealed that the heart contains functionally diverse populations of macrophages derived from distinct embryonic and adult hematopoietic progenitors. Under steady state conditions, the heart is largely populated by CCR2- macrophages of embryonic descent. Following tissue injury, a dramatic shift in macrophage composition occurs whereby CCR2+ monocytes are recruited to the heart and differentiate into inflammatory CCR2+ macrophages that contribute to heart failure progression. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314030DOI Listing
January 2019
2 Reads

James McNamara.

Circ Res 2019 Jan;124(2):192-193

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314628DOI Listing
January 2019
1 Read

The Kindlin Family of Adapter Proteins.

Circ Res 2019 Jan;124(2):202-204

From the Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314362DOI Listing
January 2019
2 Reads

Immunity and Inflammation in Atherosclerosis.

Circ Res 2019 Jan;124(2):315-327

Division of Inflammation Biology, La Jolla Institute for Immunology, CA (K.L.).

There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31359
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342482PMC
January 2019
5 Reads

Paul Simpson and Scientific Rigor.

Authors:
Roberto Bolli

Circ Res 2019 Jan;124(2):194

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314621DOI Listing
January 2019
1 Read

Statin Toxicity.

Circ Res 2019 Jan;124(2):328-350

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora (R.H.E.).

There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs frequently prescribed to lower cholesterol. However, in spite of their wide-spread use, discontinuation and nonadherence remains a major gap in both the primary and secondary prevention of atherosclerotic cardiovascular disease. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312782DOI Listing
January 2019
3 Reads

Very Small Embryonic-Like Stem Cells (VSELs).

Circ Res 2019 Jan;124(2):208-210

From the Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, KY (M.Z.R., J.R., M.K.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314287DOI Listing
January 2019
1 Read

Paul Simpson.

Authors:
Jaclyn M Jansen

Circ Res 2019 Jan;124(2):195-198

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314619DOI Listing
January 2019
1 Read