418,368 results match your criteria Circulation journal : official journal of the Japanese Circulation Society[Journal]


Current Paradigms and New Perspectives on Fetal Hypoxia: Implications for Fetal Brain Development in Late Gestation.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Pharmacodynamics, University of Florida, United States.

The availability of oxygen to the fetus is limited by the route taken by oxygen from atmosphere to fetal tissues, aided or diminished by pregnancy-associated changes in maternal physiology, and ultimately a function of atmospheric pressure and composition of the mother's inspired gas. Much of our understanding of the fetal physiological response to hypoxia comes from experiments designed to elucidate the cardiovascular and endocrine responses to transient hypoxia. Complementing this work is equally impactful research into the origins of intrauterine growth restriction, using animal models designed to restrict the transfer of oxygen from maternal to fetal circulation. Read More

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http://dx.doi.org/10.1152/ajpregu.00008.2019DOI Listing

Implication of the whitefly, , collagen protein in begomoviruses acquisition and transmission.

Phytopathology 2019 Apr 24. Epub 2019 Apr 24.

University of Delhi, 28742, Gut Biology Laboratory, Room No. 117, Department of Zoology, Delhi, Delhi, India ;

Begomoviruses are the largest group of plant viruses, transmitted exclusively by the whitefly, (Gennadius) in a persistent, circulative and non-propagative manner. Begomoviruses, in association with cause enormous loss to world agricultural crops. Transmission, retention and circulation of begomovirus in are facilitated by its interaction with several proteins of the insect and its endosymbionts. Read More

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http://dx.doi.org/10.1094/PHYTO-03-18-0082-RDOI Listing

Chronic inflammation during Osteoarthritis is associated with an increased expression of CD161 during advanced stage.

Scand J Immunol 2019 Apr 24:e12770. Epub 2019 Apr 24.

Department of Anatomy, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Increasing evidence suggests a role of inflammation during the pathogenesis of Osteoarthritis (OA). The local and systemic inflammation was studied in 33 patients of different KL grades, grade2 (n=11), grade3 (n=6) and grade4 (n=16). The levels of cytokines, adipokines, and matrixmetalloproteinases (MMPs) were measured in serum and synovial fluid (SF) by flow cytometry and ELISA respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12770
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http://dx.doi.org/10.1111/sji.12770DOI Listing
April 2019
1 Read

Mechanisms of Drug-Induced Cholestasis.

Methods Mol Biol 2019 ;1981:1-14

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Cholestasis can be defined as any situation of impaired bile secretion with concomitant accumulation of bile acids in the liver or in the systemic circulation. A variety of factors may evoke cholestasis, including genetic disorders, metabolic pathologies, infectious diseases, immunogenic stimuli, and drugs. Drug-induced cholestasis is a mechanistically complex process. Read More

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http://link.springer.com/10.1007/978-1-4939-9420-5_1
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http://dx.doi.org/10.1007/978-1-4939-9420-5_1DOI Listing
January 2019
1 Read

All things bleak and bare beneath a brazen sky: practice and place in the analysis of Australopithecus.

Authors:
Paige Madison

Hist Philos Life Sci 2019 Apr 23;41(2):19. Epub 2019 Apr 23.

Arizona State University, P.O. Box 874601, Tempe, AZ, 85287, USA.

The fossilized primate skull known as the Taungs Baby, discovered in South Africa, was put forward in 1925 as a controversial 'missing link' between humans and apes. This essay examines the controversy generated by the fossil, with a focus on practice and the circulation of material objects. Viewing the Taungs story from this perspective provides a new outlook on debates, one that suggests that attention to the importance of place, particularly the ways that specific localities shape scientific practices, is crucial to understanding such controversies. Read More

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http://dx.doi.org/10.1007/s40656-019-0258-xDOI Listing

Invasion reproductive numbers for discrete-time models.

Infect Dis Model 2019 4;4:44-72. Epub 2019 Apr 4.

Department of Mathematics, University of Texas at Arlington, 411 South Nedderman Drive Box 19408, Arlington, TX 76019, USA.

Although invasion reproductive numbers (IRNs) are utilized frequently in continuous-time models with multiple interacting pathogens, they are yet to be explored in discrete-time systems. Here, we extend the concept of IRNs to discrete-time models by showing how to calculate them for a set of two-pathogen SIS models with coinfection. In our exploration, we address how sequencing events impacts the basic reproductive number (BRN) and IRN. Read More

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http://dx.doi.org/10.1016/j.idm.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468161PMC

Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation.

Adv Sci (Weinh) 2019 Apr 19;6(8):1802104. Epub 2019 Feb 19.

Biotechnology Center Center for Molecular and Cellular Bioengineering TU Dresden Tatzberg 47-49 01307 Dresden Germany.

Human bone marrow mesenchymal stromal cells (MSCs) are used in clinical trials for the treatment of systemic inflammatory diseases due to their regenerative and immunomodulatory properties. However, intravenous administration of MSCs is hampered by cell trapping within the pulmonary capillary networks. Here, it is hypothesized that traditional 2D plastic-adherent cell expansion fails to result in appropriate morphorheological properties required for successful cell circulation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.2018021
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http://dx.doi.org/10.1002/advs.201802104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469243PMC
April 2019
1 Read

Septic Pulmonary Embolism Secondary to Epididymitis: Case Report and Literature Review.

Case Rep Radiol 2019 19;2019:5395090. Epub 2019 Mar 19.

Hospital Universitario Mayor Méderi, Universidad del Rosario, Bogotá, Colombia.

Background: Septic pulmonary embolism (SPE) is defined as the occurrence of septic thrombi in the pulmonary circulation. We report a case of SPE secondary to epididymitis.

Case Presentation: A 74-year-old male with a history of diabetes mellitus experienced SPE secondary to epididymitis, with isolation of in blood and presence of lung nodules, with a chest computed tomography showing the halo and reversed halo signs. Read More

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http://dx.doi.org/10.1155/2019/5395090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444252PMC

primarily forages in residential areas in Kandal, Cambodia.

Ecol Evol 2019 Apr 13;9(7):4181-4191. Epub 2019 Mar 13.

Institut Pasteur du Cambodge Phnom Penh Cambodia.

Bats are the second most species-rich Mammalian order and provide a wide range of ecologically important and economically significant ecosystem services. Nipah virus is a zoonotic emerging infectious disease for which pteropodid bats have been identified as a natural reservoir. In Cambodia, Nipah virus circulation has been reported in , but little is known about the spatial distribution of the species and the associated implications for conservation and public health. Read More

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http://dx.doi.org/10.1002/ece3.5046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468066PMC

Upward elevation and northwest range shifts for alpine species in the Himalaya-Hengduan Mountains region.

Ecol Evol 2019 Apr 11;9(7):4055-4064. Epub 2019 Mar 11.

Germplasm Bank of Wild Species Kunming Institute of Botany, Chinese Academy of Sciences Kunming Yunnan China.

Climate change may impact the distribution of species by shifting their ranges to higher elevations or higher latitudes. The impacts on alpine plant species may be particularly profound due to a potential lack of availability of future suitable habitat. To identify how alpine species have responded to climate change during the past century as well as to predict how they may react to possible global climate change scenarios in the future, we investigate the climatic responses of seven species of , a representative genus endemic in the alpine meadow and subnival region of the Himalaya-Hengduan Mountains. Read More

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http://dx.doi.org/10.1002/ece3.5034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467849PMC

Diversity of PEGylation methods of liposomes and their influence on RNA delivery.

Medchemcomm 2019 Mar 12;10(3):369-377. Epub 2019 Feb 12.

NRC Institute of Immunology FMBA of Russia , Moscow , Russia . Email:

Gene therapy is a promising approach for personalized medicine, but its application in humans requires development of efficient and safe vehicles. PEGylated liposomes are some of the most suitable delivery systems for nucleic acids because of their stability under physiological conditions and prolonged circulation time, compared to conventional and other types of "stealth" liposomes. / activity of PEGylated liposomes is highly dependent on PEG motif abundance. Read More

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http://dx.doi.org/10.1039/c8md00515jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457174PMC

Updated NACI recommendations for measles post-exposure prophylaxis.

Can Commun Dis Rep 2018 Sep 6;44(9):226-230. Epub 2018 Sep 6.

Public Health Agency of Canada, Centre for Immunization and Respiratory Infectious Diseases, Ottawa, ON.

Background: Human immune globulin (Ig) products are currently recommended as post-exposure prophylaxis (PEP) for measles in certain susceptible groups. However, successful measles vaccination programs in North America have led to low circulation of measles virus and most blood donors now have vaccine-derived immunity. Concurrently, the concentrations of anti-measles antibodies in human Ig products have shown trends of gradual decline and previously recommended doses and routes of administration may no longer be optimally protective. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449113PMC
September 2018

Radiation-induced vascular changes in the intracranial irradiation field in medulloblastoma survivors: An MRI study.

Radiother Oncol 2019 Apr 10;136:50-55. Epub 2019 Apr 10.

Department of Pediatric Hematology/Oncology/Hemostaseology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.

Background And Purpose: While survival times after treatment of medulloblastoma are increasing, little is known about radiochemotherapy (RCT)-induced cerebrovascular changes. High resolution vessel wall imaging (VWI) sequences are an emerging tool for the evaluation of cerebrovascular diseases. We performed VWI in medulloblastoma long-term survivors to screen for late sequelae of RCT. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.017DOI Listing

Towards high quality real-time whole genome sequencing during outbreaks using Usutu virus as example.

Infect Genet Evol 2019 Apr 20. Epub 2019 Apr 20.

ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands. Electronic address:

Recently, protocols for amplicon based whole genome sequencing using Nanopore technology have been described for Ebola virus, Zika virus, yellow fever virus and West Nile virus. However, there is some debate regarding reliability of sequencing using this technology, which is important for applications beyond diagnosis such as linking lineages to outbreaks, tracking transmission pathways and pockets of circulation, or mapping specific markers. To our knowledge, no in depth analyses of the required read coverage to compensate for the error profile in Nanopore sequencing have been described. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.015DOI Listing

Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow.

Crit Rev Oncol Hematol 2019 May 1;137:43-56. Epub 2019 Mar 1.

School of Pharmacy and Medical Sciences, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, SA, 5001, Australia. Electronic address:

Despite more attention to cell migration from circulation into the bone marrow (BM), particularly homing of haematopoietic stem/progenitor cells, the process and mechanisms of cell mobilisation from the BM into the circulation remain largely underexplored. The process of cell mobilisation or transcellular cell migration from BM into the circulation (cell egress) is a crucial biological process in mammals as it is important to maintain homeostasis of various physiological functions including, but not limited to, the immune system, erythropoiesis, platelet release, and stem cell migration. The BM microvascular system composes of a monolayer of specialized endothelial cells, called sinusoidal endothelial cells (SECs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428183019
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http://dx.doi.org/10.1016/j.critrevonc.2019.01.024DOI Listing
May 2019
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One Health approach for West Nile virus surveillance in the European Union: relevance of equine data for blood safety.

Euro Surveill 2019 Apr;24(16)

European Centre for Disease Prevention and Control (ECDC), Stockholm.

West Nile virus (WNV) infection is notifiable in humans and equids in the European Union (EU). An area where a human case is detected is considered affected until the end of the mosquito transmission season (week 48) and blood safety measures have to be implemented. We used human and equine case notifications between 2013 and 2017 to define the WNV distribution in the EU and to investigate the relevance of using equine cases as a complementary trigger for blood safety measures. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.16.1800349DOI Listing

The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model.

Ren Fail 2019 Nov;41(1):278-283

a Department of Critical Care Medicine , Second Affiliated Hospital of Guangxi Medical University , Nanning , P.R. China.

Objective: In the current study, we investigated the incidence of acute kidney injury (AKI) induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) and whether such an AKI can recover spontaneously in rats.

Methods: We used transesophageal alternating current stimulation to establish 7 min of CA rat model followed by conventional CPR. The experimental rats were randomly divided into three groups (n = 20 per group) according to the different time points after restoration spontaneous circulation (ROSC): the ROSC 24 h, ROSC 48 h, and ROSC 72 h group. Read More

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https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1
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http://dx.doi.org/10.1080/0886022X.2019.1596819DOI Listing
November 2019
1 Read

Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Pathology and Cytology, Göteborg, Sweden.

Background: The actin-binding protein filamin A (FLNA) regulates signal transduction important for cell locomotion, but the role of macrophage-specific FLNA during atherogenesis has not been explored.

Methods: We analyzed FLNA expression in human carotid atherosclerotic plaques by immunofluorescence. We also produced mice with Flna-deficient macrophages by breeding conditional Flna-knockout mice ( Flnao/ ) with mice expressing Cre from the macrophage-specific lysosome M promoter (LC). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039697DOI Listing
April 2019
2 Reads

Cardiac Troponin T and Troponin I in the General Population: Comparing and Contrasting their Genetic Determinants and Associations with Outcomes.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: There is great interest in widening the use of high sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it is not clear whether cardiac troponin T (cTnT) and troponin I (cTnI) are equivalent measures of risk in this setting. We aimed to compare and contrast i) the association of cTnT and cTnI with CVD and non-CVD outcomes, and ii) their determinants in a Genome wide association study (GWAS). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038529DOI Listing

Efficacy and Safety of Firibastat, a First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins A Phase 2, Open-Label, Multicenter, Dose-Titrating Study.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

University of Texas Southwestern Medical Center, Dallas, TX.

Background: Despite existing therapy, successful control of hypertension [HTN] in the United States is estimated at less than 50%. In Blacks, HTN occurs earlier, is more severe, controlled less often and has a higher morbidity and mortality than in Whites. Blacks are also less responsive to monotherapy with angiotensin-I converting enzyme [ACE] inhibitors or angiotensin-II receptor type 1 blockers [ARBs]. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040070DOI Listing

Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice.

Iran J Pharm Res 2018 ;17(Suppl2):111-123

Department of Pharmaceutics, School of Pharmacy & Protein Technology Research Center, Shahid Beheshti University of Medical Sciences,Tehran, Iran.

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MTX-PEG5000 was studied at 37 °C and the results indicated its high stability in plasma (T = 144 h) and a relatively rapid degradation in tissue homogenate (T = 24 h). Read More

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January 2018

Clinical features and prognosis of microscopic polyangiitis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

Clin Respir J 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory and Critical Care Medicine, Beijing, Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, Chao-Yang Hospital-Beijing Institute of Respiratory Medicine, Capital Medical University, No. 8 Gongren Tiyuchang South Road, Beijing, 100020, P.R. China.

Introduction: Pulmonary involvement in microscopic polyangiitis (MPA) is common, little is known about the clinical features of MPA with interstitial pneumonia (MPA-IP).

Objectives: This study aimed to explore the prevalence of microscopic polyangiitis associated usual interstitial pneumonia (UIP)(MPA-UIP) and compare its clinical features and prognosis with those of MPA-non-UIP and idiopathic pulmonary fibrosis (IPF).

Methods: A total of 73 patients with MPA-IP were identified and divided into MPA-UIP patients and MPA-non-UIP patients. Read More

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http://dx.doi.org/10.1111/crj.13032DOI Listing

Prosthetic Valve Endocarditis after Transcatheter Aortic Valve Implantation Complicated by Paravalvular Abscess and Treated by Pericardial Patches and Sutureless Valve Replacement.

Heart Surg Forum 2019 Apr 4;22(2):E155-E158. Epub 2019 Apr 4.

Cardiac Surgery Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Background: Endocarditis is a rare complication of transcatheter aortic valve implantation (TAVI), with an estimated 1-year incidence of 0.50% [Circulation 2015]. However, ensuing consequences are often dire, and its surgical treatment poses unique problems, due to the frequent underlying frailty of TAVI recipients. Read More

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http://dx.doi.org/10.1532/hsf.2347DOI Listing
April 2019
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The End of a Never-Ending Story.

Circulation 2019 Apr;139(17):2069-2072

Department of Electrophysiology, Heart Center - University of Leipzig, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039992DOI Listing

Putting the Measurement of Physical Capacity of Older Adults in Its Place.

Circulation 2019 Apr;139(17):2000-2002

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039116DOI Listing

Correction to: A Peculiar Wide Complex Tachycardia.

Authors:

Circulation 2019 Apr;139(17):e890

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http://dx.doi.org/10.1161/CIR.0000000000000693DOI Listing

Highlights From the Circulation Family of Journals.

Authors:

Circulation 2019 Apr;139(17):2064-2068

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041038DOI Listing

Letter by Romaguera et al Regarding Article, "Newer Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease: Meta-Analysis of Randomized Trials".

Circulation 2019 Apr;139(17):2081-2082

Heart Diseases Institute, Hospital de Bellvitge - IDIBELL (Institut d'Investigació Biomédica de Bellvitge), University of Barcelona, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038410DOI Listing

Regime shifts of Mediterranean forest carbon uptake and reduced resilience driven by multidecadal ocean surface temperatures.

Glob Chang Biol 2019 Apr 23. Epub 2019 Apr 23.

Department of Geography, Grumets Research Group, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain.

The mechanisms translating global circulation changes into rapid abrupt shifts in forest carbon capture in semi-arid biomes remain poorly understood. Here we report unprecedented multidecadal shifts in forest carbon uptake in semi-arid Mediterranean pine forests in Spain over 1950-2012. The averaged carbon sink reduction varies between 31-37%, and reaches values in the range of 50% in the most affected forest stands. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14664
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http://dx.doi.org/10.1111/gcb.14664DOI Listing
April 2019
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Left Ventricular Hemodynamics with an Implanted Assist Device: An In Vitro Fluid Dynamics Study.

Ann Biomed Eng 2019 Apr 22. Epub 2019 Apr 22.

PoF, UTwente, Drienerlolaan 5, 7522NB, Enschede, The Netherlands.

Left ventricle assist devices (VADs) aid the heart pumping blood into the systemic circulation and grant the required cardiac output (CO) when the heart itself cannot provide it. However, it is unclear how effective these devices are at restoring not only physiological CO values but also normal intraventricular hemodynamics. In this work, the modified hemodynamics due to a VAD implantation is studied in vitro using an elastic ventricle made of silicone, which is incorporated into a pulse-duplicator setup prescribing a realistic pulsatile flow. Read More

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http://dx.doi.org/10.1007/s10439-019-02273-6DOI Listing

Bithalamic Infarction (Artery of Percheron Occlusion) after Anterior Cervical Discectomy and Fusion.

Case Rep Neurol Med 2019 18;2019:9438089. Epub 2019 Mar 18.

Neurosurgery Department, Bonifatius Hospital, Lingen, Germany.

Bithalamic infarction resulting from occlusion of the artery of Percheron after cervical spine surgery is a rare pathological entity. Diagnosis and early detection are challenging. Prompt management may help to improve the outcome. Read More

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http://dx.doi.org/10.1155/2019/9438089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442480PMC

Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions.

Proc Natl Acad Sci U S A 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180;

Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains of heparan sulfate into the circulation. These domains are oligosaccharides rich in heparin-like trisulfated disaccharide repeating units. Using a chemoenzymatic approach, an undecasaccharide containing a uniformly C-labeled internal 2-sulfoiduronic acid residue was synthesized on a -nitrophenylglucuronide acceptor. Read More

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http://dx.doi.org/10.1073/pnas.1902227116DOI Listing
April 2019
1 Read

Bicarbonate Resensitization of Methicillin-Resistant to β-Lactam Antibiotics.

Antimicrob Agents Chemother 2019 Apr 22. Epub 2019 Apr 22.

Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA.

Endovascular infections caused by methicillin-resistant () are a major healthcare concern, especially infective endocarditis (). Standard antimicrobial susceptibility testing () defines most MRSA strains as 'resistant' to β-lactams, often leading to use of costly and/or toxic treatment regimens. In this investigation, five prototype MRSA strains, representing the range of genotypes in current clinical circulation, were studied. Read More

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http://dx.doi.org/10.1128/AAC.00496-19DOI Listing

Repetitive Episodic Isolated Vertigo in a Patient with Cerebellar Infarction.

J Stroke Cerebrovasc Dis 2019 Apr 19. Epub 2019 Apr 19.

Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Isolated vertigo is an important symptom of posterior circulation stroke. It has been reported that 11.3% of patients with isolated vertigo have a stroke and that most lesions are located in the cerebellum, particularly in the posterior inferior cerebellar artery. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.051DOI Listing

Treatment and Prevention of Hypertensive Disorders During Pregnancy.

Clin Perinatol 2019 Jun 30;46(2):173-185. Epub 2019 Mar 30.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of South Florida, Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.

This article reviews the pharmacology of the most commonly used antihypertensive medications during pregnancy; their mechanism of action; and the effects on the mother, the fetus, and lactation. Each class of antihypertensive pharmacologic agents have specific mechanisms of action by which they exert their antihypertensive effect. β-Adrenoreceptor antagonists block these receptors in the peripheral circulation. Read More

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http://dx.doi.org/10.1016/j.clp.2019.02.002DOI Listing

Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases.

Lipids Health Dis 2019 Apr 22;18(1):104. Epub 2019 Apr 22.

Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou, 225009, China.

Background: In recent years, an increasing number of studies have proved that circulating miRNAs could be used for the early diagnosis of cardiovascular diseases and even play vital roles in the evaluation of therapeutic effects or prognosis. This study was conducted to examine the correlation between serum microRNAs and hyperlipidemia to provide a theoretical basis for the early screening and intervention of atherosclerotic cardiovascular diseases (ASCVD).

Methods: The serum samples and clinical data of 122 patients with hyperlipidemia and 168 healthy subjects were collected. Read More

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http://dx.doi.org/10.1186/s12944-019-1046-zDOI Listing

Application of the Orthogonal Polynomial Fitting Method in Estimating PM Concentrations in Central and Southern Regions of China.

Int J Environ Res Public Health 2019 Apr 19;16(8). Epub 2019 Apr 19.

Physical Oceanography Laboratory/CIMST, Ocean University of China and Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China.

Sufficient and accurate air pollutant data are essential to analyze and control air contamination problems. An orthogonal polynomial fitting (OPF) method using Chebyshev basis functions is introduced to produce spatial distributions of fine particle (PM) concentrations in central and southern regions of China. Idealized twin experiments (IE1 and IE2) are designed to validate the feasibility of the OPF method. Read More

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http://dx.doi.org/10.3390/ijerph16081418DOI Listing

Tumor-Associated Neutrophils in Cancer: Going Pro.

Cancers (Basel) 2019 Apr 19;11(4). Epub 2019 Apr 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, USA.

The progression of cancer is not only about the tumor cell itself, but also about other involved players including cancer cell recruited immune cells, their released pro-inflammatory factors, and the extracellular matrix. These players constitute the tumor microenvironment and play vital roles in the cancer progression. Neutrophils-the most abundant white blood cells in the circulation system-constitute a significant part of the tumor microenvironment. Read More

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http://dx.doi.org/10.3390/cancers11040564DOI Listing

First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain.

Viruses 2019 Apr 19;11(4). Epub 2019 Apr 19.

Arbovirus and Imported Viral Diseases Laboratory, National Centre of Microbiology, Majadahonda, 28220 Madrid, Spain.

Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats ( = 60), common serotine bats ( = 10) as controls, and humans ( = 22) using an immunoblot assay. We found antibodies against LLOV GP in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. Read More

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http://dx.doi.org/10.3390/v11040360DOI Listing

Polyphenol Microbial Metabolites Exhibit Gut and Blood⁻Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation.

Metabolites 2019 Apr 19;9(4). Epub 2019 Apr 19.

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.

Increasing evidence supports the beneficial effects of polyphenol-rich diets, including the traditional Mediterranean diet, for the management of cardiovascular disease, obesity and neurodegenerative diseases. However, a common concern when discussing the protective effects of polyphenol-rich diets against diseases is whether these compounds are present in systemic circulation in their intact/parent forms in order to exert their beneficial effects in vivo. Here, we explore two common classes of dietary polyphenols, namely isoflavones and lignans, and their gut microbial-derived metabolites for gut and blood-brain barrier predicted permeability, as well as protection against neuroinflammatory stimuli in murine BV-2 microglia. Read More

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http://dx.doi.org/10.3390/metabo9040078DOI Listing

The Crosstalk Between Cell Adhesion and Cancer Metabolism.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Ipatimup-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.

Cancer cells preferentially use aerobic glycolysis over mitochondria oxidative phosphorylation for energy production, and this metabolic reprogramming is currently recognized as a hallmark of cancer. Oncogenic signaling frequently converges with this metabolic shift, increasing cancer cells' ability to produce building blocks and energy, as well as to maintain redox homeostasis. Alterations in cell-cell and cell-extracellular matrix (ECM) adhesion promote cancer cell invasion, intravasation, anchorage-independent survival in circulation, and extravasation, as well as homing in a distant organ. Read More

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http://dx.doi.org/10.3390/ijms20081933DOI Listing

Cervical artery dissection after sports - An analytical evaluation of 190 published cases.

Eur Stroke J 2017 Dec 10;2(4):335-345. Epub 2017 Jul 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Introduction: Cervical artery dissections may be preceded by mechanical trigger events, often related to sports.

Methods: Using the MEDLINE database, we identified case reports and case series of sports-related cervical artery dissections. Information of the type of sport, age and gender of the patient, affected vessels, associated infarction, time delay, and neurological sequelae were extracted. Read More

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http://dx.doi.org/10.1177/2396987317720544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453193PMC
December 2017

Increased risk for posterior circulation ischaemia in patients with vertebral artery hypoplasia: A systematic review and meta-analysis.

Eur Stroke J 2017 Jun 20;2(2):171-177. Epub 2017 Mar 20.

Department of Neurology, University of Ioannina School of Medicine, Ioannina, Greece.

Introduction: Although several study protocols reported that vertebral artery hypoplasia can predispose to posterior circulation ischaemia, the role of vertebral artery hypoplasia in the risk of posterior circulation ischaemia still remains controversial. The aim of the present meta-analysis was to investigate the association of vertebral artery hypoplasia and posterior circulation ischaemia.

Patients And Methods: We performed a systematic review and random effects meta-analysis of all eligible observational study protocols reporting prevalence rates of vertebral artery hypoplasia in patients with anterior circulation ischaemia and posterior circulation ischaemia. Read More

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http://dx.doi.org/10.1177/2396987317700540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453216PMC

Improving reperfusion time within the ESCAPE Endovascular Clinical Trial.

Eur Stroke J 2017 Mar 30;2(1):64-69. Epub 2016 Nov 30.

Departments of Clinical Neurosciences, Medicine, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.

Introduction: Endovascular treatment of acute ischemic stroke is more effective when performed quickly. In this report, we describe quality interventions to ensure fast endovascular treatment times in the ESCAPE (Endovascular Treatment for Small Core and Anterior circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times) trial.

Methods: An "audit and feedback" intervention using webinar and letter was used to improve treatment time over the course of the trial. Read More

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http://dx.doi.org/10.1177/2396987316681176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453179PMC

Clot length predicts recanalisation but not outcome after basilar artery occlusion.

Eur Stroke J 2016 Dec 12;1(4):330-336. Epub 2016 Oct 12.

Brain Center Rudolf Magnus, Department Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Introduction: The aim of our study was to evaluate the effect of clot length on both recanalisation and outcome in acute basilar artery occlusion (BAO).

Patients And Methods: One hundred forty-nine patients with an acute basilar artery occlusion from the Basilar Artery International Cooperation Study (BASICS) were included. Clot length was assessed on computed tomographic angiography. Read More

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http://dx.doi.org/10.1177/2396987316673265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301249PMC
December 2016
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