416,065 results match your criteria Circulation journal : official journal of the Japanese Circulation Society[Journal]


Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.

J Nutr Biochem 2019 Jan 7;66:70-78. Epub 2019 Jan 7.

Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory on Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.. Electronic address:

Oxidative stress is considered an important pathogenic process of cardiac hypertrophy. Lycopene is a kind of carotenoid antioxidant that protects the cardiovascular system, so we hypothesized that lycopene might inhibit cardiac hypertrophy by attenuating oxidative stress. Phenylephrine and pressure overload were used to set up the hypertrophic models in vitro and in vivo respectively. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.002DOI Listing
January 2019

Hydrodynamic modelling of a polluted tropical bay: Assessment of anthropogenic impacts on freshwater runoff and estuarine water renewal.

J Environ Manage 2019 Feb 14;236:695-714. Epub 2019 Feb 14.

Universidad EAFIT, School of Sciences, Department of Earth Sciences, Carrera 49 #7S-50, A.A.3300, Medellín, Colombia.

A bay's capacity to buffer fluvial fluxes between the land and sea is sensitive to hydrological changes that can affect its water renewal rates. In Cartagena Bay, Colombia, pollution issues have been associated with freshwater fluxes which are projected to increase in future years. This has led to plans to reduce freshwater flows by constructing upstream hydraulic doors. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.01.104DOI Listing
February 2019

Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo.

J Colloid Interface Sci 2019 Jan 23;542:469-482. Epub 2019 Jan 23.

Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR-7504, CNRS-Université de Strasbourg, 23 rue du Loess, BP 34 67034, Strasbourg Cedex 2, France. Electronic address:

The engineering of luminescent nanoplatforms for biomedical applications displaying ability for scaling-up, good colloidal stability in aqueous solutions, biocompatibility, and providing an easy detection in vivo by fluorescence methods while offering high potential of functionalities, is currently a challenge. The original strategy proposed here involves the use of large pore (ca. 15 nm) mesoporous silica (MS) nanoparticles (NPs) having a stellate morphology (denoted STMS) on which fluorescent InP/ZnS quantum dots (QDs) are covalently grafted with a high yield (≥90%). Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.098DOI Listing
January 2019

Heparin during endovascular stroke treatment seems safe Heparin during endovascular stroke treatment does not ameliorate clinical outcome and is associated with lower chance of reperfusion.

J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

Comprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. Electronic address:

Background And Purpose: the effect of intravenous heparin during mechanical thrombectomy for acute ischemic stroke is not clear. We aimed to study efficacy and safety of heparin use during endovascular stroke treatment in a real-world setting.

Materials And Methods: patients with anterior circulation stroke were divided, based on the use of intraprocedural heparin, in those treated and those untreated. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.01.095DOI Listing
February 2019

The Circle of Life: Vieussens' Arterial Ring.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2018.12.016DOI Listing
February 2019

In utero intervention for severe congenital heart disease.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 17. Epub 2019 Jan 17.

The Fetal Center, Children's Memorial Hermann Hospital and the Department of Obstetrics and Gynecology, McGovern Medical School, UTHealth, Houston, TX, USA. Electronic address:

The aim of foetal cardiac therapy is to treat an abnormality at the developmental stage so that the process of cardiac growth, which is complex and relies on the volume and direction of circulating blood as well as genetic determinants, can continue. In reality, most cardiac interventions are palliative; hence, major abnormalities are still present at birth. Nevertheless, tangible benefits following successful foetal intervention include improved haemodynamics and reduction in secondary damage leading to better postnatal outcomes. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.007DOI Listing
January 2019

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract.

Authors:
Robert O Gilbert

J Dairy Sci 2019 Feb 13. Epub 2019 Feb 13.

Ross University School of Veterinary Medicine, PO Box 334, Basseterre, St. Kitts and Nevis, West Indies. Electronic address:

Diseases of postpartum dairy cows impair reproductive processes, resulting in prolonged anestrus, reduced conception, and increased pregnancy attrition, regardless of whether the initial disease precedes insemination (even by many weeks), occurs close to insemination, or follows fertilization. Bacteria and their products activate pattern recognition receptors that respond to pathogen-associated molecular patterns (PAMP). These receptors include toll-like receptors (TLR), nucleotide-binding oligomerization domain (NOD)-like receptors and others, and their activation culminates in upregulation of proinflammatory cytokines such as IL-1β, IL-18, and tumor necrosis factor-α. Read More

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http://dx.doi.org/10.3168/jds.2018-15602DOI Listing
February 2019

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.

Redox Biol 2019 Jan 29;22:101128. Epub 2019 Jan 29.

Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Av. Salvador 486, Providencia 7500922, Santiago, Chile; International Center for Andean Studies (INCAS), Universidad de Chile, Baquedano s/n, Putre, Chile. Electronic address:

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties that decrease oxidative stress and improves pulmonary vascular function when administered postnatally. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101128DOI Listing
January 2019
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Guideline removal of atropine and survival after adult in-hospital cardiac arrest with a non-shockable rhythm.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus Universitsy Hospital, Aarhus, Denmark; Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Aim: To determine whether the removal of atropine from the 2010 ACLS guidelines for non-shockable cardiac arrests was associated with a change in survival.

Methods: Using the Get With The Guidelines®-Resuscitation registry, we included adults with an index in-hospital cardiac arrest between 2006 and 2015. The primary outcome was survival to hospital discharge. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.002DOI Listing
February 2019

Variability in survival and post-cardiac arrest care following successful resuscitation from out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Aim Of The Study: Regionalization of care for out-of-hospital cardiac arrests (OHCA) may improve patient outcomes. We evaluated inter-hospital variations in post-arrest care provision and the relation between hospital case volume and survival in Pennsylvania.

Methods: This retrospective study (2013-2017) used data from adult OHCA cases in Pennsylvania from the Cardiac Arrest Registry to Enhance Survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.004DOI Listing
February 2019

Effect of cancer history on post-resuscitation treatments in out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Medicine, Seoul National University Hospital, Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Objectives: There is growing evidence that optimal post-resuscitation treatment is a significant factor for overall survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA). However, there is also growing evidence of disparities in treatments in vulnerable populations such as elderly individuals or patients with underlying diseases, including cancer.

Aim: The aim of this study was to evaluate the influence of cancer status on post-resuscitation therapies among OHCA patients. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.005DOI Listing
February 2019

Randomized Trial of Miniaturized versus Standard Extracorporeal Circulation in Aortic Valve Surgery.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Dept. of Cardio-Thoracic Surgery, Thoraxcentrum Twente, Medisch Spectrum Twente Hospital, P.O. Box 50 000, 7500 KA Enschede, The Netherlands; Dept. of Cardio-Thoracic Surgery, University Medical Center Groningen, P.O. Box 30 001, 9700 RB Groningen, The Netherlands.

Background: Complications related to extracorporeal circulation remain serious. While a Minimal Invasive Extra Corporeal Circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.019DOI Listing
February 2019

Randomized Trial of Miniaturized versus Standard Extracorporeal Circulation in Aortic Valve Surgery (Commentary).

Authors:
William L Holman

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

University of Alabama at Birmingham, Department of Surgery, 1530 3rd Avenue South - ZRB 719, Birmingham, AL. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.026DOI Listing
February 2019

Nox2-mediated platelet activation by glycoprotein (GP) VI: effect of rivaroxaban alone and in combination with aspirin.

Biochem Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Electronic address:

Factor Xa (FXa) has been reported to activate platelet via interaction with glycoprotein (GP) VI but the underlying mechanism has not been fully elucidated. We investigated if Nox2-derived oxidative stress is implicated in FXa-induced platelet aggregation (PA), and the effect of a FXa inhibitor, namely rivaroxaban, with or without aspirin (ASA), on PA. We performed an in vitro study measuring convulxin-induced PA, thromboxane (Tx) B and isoprostanes biosynthesis, soluble Nox2-dp (sNox2-dp), a marker of Nox2 activation, soluble GPVI (sGPVI) and PLA activation in platelets from healthy subjects (n=5) added with and without a Nox2 inhibitor. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.016DOI Listing
February 2019

Sensitivity and reliability of cerebral oxygenation responses to postural changes measured with near-infrared spectroscopy.

Eur J Appl Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Heijendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

Purpose: Cerebral oxygenation as measured by near-infrared spectroscopy (NIRS) might be useful to discriminate between physiological and pathological responses after standing up in individuals with orthostatic hypotension. This study addressed the physiological sensitivity of the cerebral oxygenation responses as measured by NIRS to different types and speeds of postural changes in healthy adults and assessed the reliability of these responses.

Methods: Cerebral oxygenated hemoglobin (OHb), deoxygenated hemoglobin (HHb) and tissue saturation index (TSI) were measured bilaterally on the forehead of 15 healthy individuals (12 male, age range 18-27) using NIRS. Read More

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http://dx.doi.org/10.1007/s00421-019-04101-0DOI Listing
February 2019

Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation.

Pediatr Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Child Development and Exercise Center, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB, Utrecht, The Netherlands.

There are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory fitness in children and young adults with a Fontan circulation. Altogether, 17 Fontan patients and 26 healthy controls (16 females and 27 males aged 8-40 years) participated in this cross-sectional study. Read More

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http://dx.doi.org/10.1007/s00246-019-02065-8DOI Listing
February 2019

Impact of the Atlantic Multidecadal Oscillation on the Pacific North Equatorial Current bifurcation.

Sci Rep 2019 Feb 15;9(1):2162. Epub 2019 Feb 15.

Department of Oceanography, University of Hawaii at Manoa, Honolulu, Hawaii, USA.

Variability in surface currents is mainly induced by the time-varying wind forcing. Recent studies have revealed robust pronounced changes in the atmospheric circulation over the Pacific came with the Pacific Decadal Oscillation (PDO). However, the PDO is a climate index based on sea surface temperature (SST) variations, and may not be appropriately considered as a climate forcing. Read More

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http://dx.doi.org/10.1038/s41598-019-38479-wDOI Listing
February 2019

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.021DOI Listing
February 2019

Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions.

J Chem Phys 2019 Feb;150(6):064909

The Rudolf Peierls Centre for Theoretical Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, United Kingdom.

We numerically study the dynamics of two-dimensional blue phases in active chiral liquid crystals. We show that introducing contractile activity results in stabilised blue phases, while small extensile activity generates ordered but dynamic blue phases characterised by coherently moving half-skyrmions and disclinations. Increasing extensile activity above a threshold leads to the dissociation of the half-skyrmions and active turbulence. Read More

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http://dx.doi.org/10.1063/1.5085282DOI Listing
February 2019

Alveolar-Capillary Membrane-Related Pulmonary Cells as a Target in Endotoxin-Induced Acute Lung Injury.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Physiology and Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.

The main function of the lungs is oxygen transport from the atmosphere into the blood circulation, while it is necessary to keep the pulmonary tissue relatively free of pathogens. This is a difficult task because the respiratory system is constantly exposed to harmful substances entering the lungs by inhalation or via the blood stream. Individual types of lung cells are equipped with the mechanisms that maintain pulmonary homeostasis. Read More

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http://dx.doi.org/10.3390/ijms20040831DOI Listing
February 2019

Identification and Extraction Optimization of Active Constituents in Seib ex TANAKA Peel and Its Biological Evaluation.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Korea.

Seib ex TANAKA possesses various biological effects. It has been used in oriental remedies for blood circulation and the common cold. Recently, biological effects of peel have been reported. Read More

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http://dx.doi.org/10.3390/molecules24040680DOI Listing
February 2019
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Selective photochromism in self-coated WO3/WO3-x homojunction: enhanced solar modulation efficiency, high luminous transmittance and fast self-bleaching rate.

Nanotechnology 2019 Feb 15. Epub 2019 Feb 15.

Shanghai Institute of Ceramics Chinese Academy of Sciences, Changning District, Shanghai, CHINA.

Pursuing excellent photochromic (PC) property is still a longstanding challenge for energy-efficient smart coatings. Herein, we have prepared a novel series of self-coated crystalline WO3-amorphous WO3-x homojunction by one-step hydrothermal process, in which oxalic acid was used for a capping agent to prevent polycondenstation and crystallization of [WO6]. The as-prepared nanopowders have large specific surface area and rich surface electron, which lead to a dramatic photochromic property reaching up to △Tsol=64. Read More

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http://dx.doi.org/10.1088/1361-6528/ab0778DOI Listing
February 2019

Retinal capillary perfusion: Spatial and temporal heterogeneity.

Prog Retin Eye Res 2019 Feb 12. Epub 2019 Feb 12.

Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia; Lions Eye Institute, The University of Western Australia, Perth, Australia.

The central role of the cardiovascular system is to maintain adequate capillary perfusion. The spatially and temporally heterogeneous nature of capillary perfusion has been reported in some organs. However, such heterogeneous perfusion properties have not been sufficiently explored in the retina. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.01.001DOI Listing
February 2019

Does increased 11 β HSD- 1 activity induce adverse metabolic phenotype only in lean ?

Clin Endocrinol (Oxf) 2019 Feb 15. Epub 2019 Feb 15.

Medical College and Hospital Kolkata, Department of Endocrinology and Metabolism, Kolkata, West Bengal, India.

We read with interest article by Crowley et al (1). The authors a found an apparent decrease in 11 β HSD- 1 expression in subcutaneous adipose tissue (SAT) of deteriorators as compared to improvers. They explained it as compensatory decrease of 11 β HSD- 1 activity as consequence of overall adverse metabolic phenotype. Read More

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http://dx.doi.org/10.1111/cen.13950DOI Listing
February 2019

Long-Term Effect of Decompressive Craniectomy on Intracranial Pressure and Possible Implications for Intracranial Fluid Movements.

Neurosurgery 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.

Background: Decompressive craniectomy (DC) is used in cases of severe intracranial hypertension or impending intracranial herniation. DC effectively lowers intracranial pressure (ICP) but carries a risk of severe complications related to abnormal ICP and/or cerebrospinal fluid (CSF) circulation, eg, hygroma formation, hydrocephalus, and "syndrome of the trephined."

Objective: To study the long-term effect of DC on ICP, postural ICP regulation, and intracranial pulse wave amplitude (PWA). Read More

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http://dx.doi.org/10.1093/neuros/nyz049DOI Listing
February 2019

Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.

Food Funct 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China and National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China and Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

The management of lead (Pb) exposure and toxicity remains a major public health priority worldwide. In our previous study, the probiotic strain Lactobacillus plantarum CCFM8661 prevented Pb absorption in mice via intestinal sequestration. This follow-up study aimed to evaluate the additional protective mechanism of L. Read More

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http://dx.doi.org/10.1039/c8fo02554aDOI Listing
February 2019

Self-imaging of tailored vortex pulse arrays and spectral Gouy rotation echoes.

Opt Lett 2019 Feb;44(4):1047-1050

Self-imaging of femtosecond pulses with orbital angular momentum is studied in spectral domain by illuminating the orthogonal arrays of spiral gratings. Spectral Gouy rotation, i.e. Read More

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http://dx.doi.org/10.1364/OL.44.001047DOI Listing
February 2019

Proximal pressure reducing effect of wave reflection in the pulmonary circulation disappear in obstructive disease: insight from a rabbit model.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

IBiTech-bioMMeda, Ghent University, Belgium.

Locating the site of increased resistance within the vascular tree in pulmonary arterial hypertension (PAH), could assist in both patient diagnosis and tailoring treatment. Wave intensity analysis (WIA) is a wave analysis method that may be capable of localizing the major site of reflection within a vascular system. We investigated the contribution of WIA to the analysis of the pulmonary circulation in a rabbit model with animals subjected to variable occlusive pulmonary disease. Read More

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http://dx.doi.org/10.1152/ajpheart.00635.2018DOI Listing
February 2019

Finding Roles of Players in Football Using Automatic Practice Swarm Optimization-Clustering Algorithm.

Big Data 2019 Feb 15. Epub 2019 Feb 15.

3 KDD Lab, ISTI-CNR, Pisa, Italy.

Recently, professional team sport organizations have invested their resources to analyze their own and opponents' performance. So, developing methods and algorithms for analyzing team sports has become one of the most popular topics among data scientists. Analyzing football is hard because of its complexity, number of events in each match, and constant flow of circulation of the ball. Read More

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http://dx.doi.org/10.1089/big.2018.0069DOI Listing
February 2019

Diagnostic value of eye movement and vestibular function tests in patients with posterior circulation infarction.

Acta Otolaryngol 2019 Feb 15:1-11. Epub 2019 Feb 15.

a Peking University Aerospace School of Clinical Medicine , Beijing , P.R. China.

Objective: To evaluate the diagnostic value of eye movements and vestibular function tests in PCI patients.

Methods: Thirty-eight PCI patients and 31 patients with unilateral vestibular neuritis (UVN) were enrolled and underwent eye movement tests and vestibular function tests (spontaneous nystagmus [SN], head-shaking nystagmus [HSN]).

Results: The rates of eye movement abnormality were 78. Read More

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https://www.tandfonline.com/doi/full/10.1080/00016489.2018.1
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http://dx.doi.org/10.1080/00016489.2018.1552367DOI Listing
February 2019
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Nanostructured cochleates: A multi-layered platform for cellular transportation of therapeutics.

Drug Dev Ind Pharm 2019 Feb 15:1-37. Epub 2019 Feb 15.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM's NMIMS , V. L. Mehta Road , Vile Parle (W), Mumbai , India.

Among lipid-based nanocarriers, multi-layered cochleates emerge as a novel delivery system because of prevention of oxidation of hydrophobic and hydrophilic drugs, enhancement in permeability and reduction in dose of drugs. It also improves oral bioavailability and increases the safety of a drug by targeting at a specific site with less side effects. Nanostructured cochleates are used as a carrier for the delivery of water-insoluble or hydrophobic drugs of anti-cancer, antiviral and anti-inflammatory action. Read More

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http://dx.doi.org/10.1080/03639045.2019.1583757DOI Listing
February 2019

Expression of Concern

Authors:

Circulation 2019 Jan;139(3):e5-e6

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January 2019

Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction

Circulation 2018 Dec;138(24):2754-2762

Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden

Background: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036220DOI Listing
December 2018

Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems' Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial.

Cardiovasc Intervent Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: To investigate the safety and toxicity of percutaneous hepatic perfusion with melphalan (M-PHP) with the Delcath Systems' second-generation (GEN 2) filter and compare the outcomes with historical data from studies using the first-generation filter.

Materials And Methods: A prospective, single-arm, single-center phase II study was carried out including 35 patients with unresectable, histologically confirmed liver metastases from ocular melanoma between February 2014 and June 2017. Main exclusion criteria were extrahepatic disease and age > 75 years. Read More

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http://dx.doi.org/10.1007/s00270-019-02177-xDOI Listing
February 2019

Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.

Hepatol Commun 2019 Feb 17;3(2):227-245. Epub 2018 Dec 17.

Institute of Molecular Biosciences University of Graz Graz Austria.

Murine hepatic carboxylesterase 2c () and the presumed human ortholog carboxylesterase 2 () have been implicated in the development of nonalcoholic fatty liver disease (NAFLD) in mice and obese humans. These studies demonstrated that hydrolyzes triglycerides (TGs) in hepatocytes. Interestingly, / is most abundantly expressed in the intestine, indicating a role of / in intestinal TG metabolism. Read More

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http://dx.doi.org/10.1002/hep4.1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357831PMC
February 2019

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects.

J Ophthalmol 2019 15;2019:7419470. Epub 2019 Jan 15.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA).

Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. Read More

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http://dx.doi.org/10.1155/2019/7419470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350555PMC
January 2019

Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair.

Stem Cells Int 2019 15;2019:9310318. Epub 2019 Jan 15.

Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, Universites of Paris-Descartes, Pierre and Marie Curie and Paris-Diderot, 15 rue de l'école de médecine, Paris, France.

A large array of therapeutic procedures is available to treat cartilage disorders caused by trauma or inflammatory disease. Most are invasive and may result in treatment failure or development of osteoarthritis due to extensive cartilage damage from repeated surgery. Despite encouraging results of early cell therapy trials that used chondrocytes collected during arthroscopic surgery, these approaches have serious disadvantages, including morbidity associated with cell harvesting and low predictive clinical outcomes. Read More

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http://dx.doi.org/10.1155/2019/9310318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350557PMC
January 2019

Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria.

Afr Health Sci 2018 Dec;18(4):1134-1143

Department of Virology, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity.

Objectives: This study was designed to identify the circulating influenza virus in Ibadan, Nigeria during the 2006/2007 season.

Methods: Throat swab samples were collected from patients presenting with acute respiratory tract infection at the Out-Patient Departments of major hospitals in Ibadan over a period of seven months from November 2006 to May 2007. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354865PMC
December 2018

Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.

Sci Rep 2019 Feb 14;9(1):2034. Epub 2019 Feb 14.

Department of Congenital Heart Disease and Pediatric Cardiology, DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3, Kiel, Germany.

The Fontan procedure provides relief from cyanosis in patients with univentricular hearts. A major clinical unmet need is to understand whether the venous flow patterns of the Fontan circulation lead to the development of congestive hepatopathy and other life-threatening complications. Currently, there is no consensus on whether heart beat or respiration is the main driving force of venous return and which one affects the periodic flow changes for the most (i. Read More

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http://dx.doi.org/10.1038/s41598-019-38848-5DOI Listing
February 2019

Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of Re radionuclide for cancer therapy.

Sci Rep 2019 Feb 14;9(1):2017. Epub 2019 Feb 14.

MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia.

Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic Re radionuclide. Read More

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http://dx.doi.org/10.1038/s41598-018-38474-7DOI Listing
February 2019

Inferring Earth's discontinuous chemical layering from the 660-kilometer boundary topography.

Science 2019 Feb;363(6428):736-740

Department of Geosciences, Princeton University, Princeton, NJ 08544, USA.

Topography, or depth variation, of certain interfaces in the solid Earth can provide important insights into the dynamics of our planet interior. Although the intermediate- and long-range topographic variation of the 660-kilometer boundary between Earth's upper and lower mantle is well studied, small-scale measurements are far more challenging. We found a surprising amount of topography at short length scale along the 660-kilometer boundary in certain regions using scattered seismic waves. Read More

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http://dx.doi.org/10.1126/science.aav0822DOI Listing
February 2019

Predictors and Clinical Impact of Delayed Stent Thrombosis after Thrombectomy for Acute Stroke with Tandem Lesions.

AJNR Am J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

From the Interventional Neuroradiology Department (R.P., D.M., M.M., J.S.R., R.B.).

Background And Purpose: There are very few published data on the patency of carotid stents implanted during thrombectomies for tandem lesions in the anterior circulation. We aimed to communicate our experience of stenting in the acute setting with systematic follow-up of stent patency and discuss predictors and clinical repercussions of delayed stent thrombosis.

Materials And Methods: We performed a retrospective study of stroke thrombectomies in a single center between January 2009 and April 2018. Read More

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http://dx.doi.org/10.3174/ajnr.A5976DOI Listing
February 2019

An Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid.

J Nanosci Nanotechnol 2019 Jul;19(7):3720-3733

Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700032, India.

Among the different types of polymeric vehicles, (PLGA) is biodegradable and has emerged as promising tool for the delivery of cancer therapeutics. The salient features of PLGA micro carriers include prolonged circulation time, increased tumor localization and biodegradability and effectiveness of the therapeutics. We have synthesized PLGA microspheres where curcumin can be loaded and thereby increases its bioavailability. Read More

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http://dx.doi.org/10.1166/jnn.2019.16292DOI Listing

Twenty-and-a-half syndrome: a case report.

J Med Case Rep 2019 Feb 15;13(1):35. Epub 2019 Feb 15.

Department of Neurology, Sri Aurobindo Medical College & P.G. Institute, 4th Floor, Sanwer Road, Indore, MP, 453555, India.

Background: In the list of named numerical neuro-ophthalmological syndromes, such as one-and-a-half syndrome and others, we report for the first time twenty-and-a-half syndrome, which is characterized by one-and-a-half syndrome with bilateral seventh and right fifth nerve palsy (1.5 + 7 + 7 + 5 = 20.5) in a patient with ischemic stroke. Read More

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http://dx.doi.org/10.1186/s13256-019-1980-4DOI Listing
February 2019

Circulation of influenza A and B in the Czech Republic from 2000-2001 to 2015-2016.

BMC Infect Dis 2019 Feb 14;19(1):160. Epub 2019 Feb 14.

Department of Infectious Diseases Epidemiology, National Institute of Public Health, Prague, Czech Republic.

Background: To improve national influenza vaccination recommendations, additional data on influenza A and B virus circulation are needed. Here, we describe the circulation of influenza A and B in the Czech Republic during 16 seasons.

Methods: This was a retrospective analysis of data collected from the 2000-2001 to 2015-2016 influenza seasons by the Czech Republic national influenza surveillance network. Read More

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http://dx.doi.org/10.1186/s12879-019-3783-zDOI Listing
February 2019

High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Cedars-Sinai Smidt Heart Institute, CA.

Background: Hookah smoking is marketed to youth as a harmless alternative to cigarettes. While cigarette smoking acutely impairs endothelial function, the effect of smoking fruit flavored hookah tobacco is unknown. Because charcoal traditionally is used to heat the hookah tobacco in the waterpipe, hookah smoke delivers tobacco toxicants and nicotine plus charcoal combustion products: not only carbon-rich nanoparticles-oxidants that may destroy nitric oxide and impair endothelial function-but also large amounts of carbon monoxide (CO), a putative vasodilator molecule. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037375DOI Listing
February 2019

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Biochemistry, Osaka University Graduate School of Medicine, Japan.

Background: Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia has identified a growing number of causative gene mutations. Since the only ultimate treatment for symptomatic bradyarrhythmia has been invasive surgical implantation of a pacemaker, the discovery of novel therapeutic molecular targets is necessary to improve prognosis and quality of life. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036761DOI Listing
February 2019

Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Department of Experimental and Clinical Medicine-Section of Anatomy and Histology, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

The morpho-functional recovery of injured skeletal muscle still represents an unmet need. None of the therapeutic options so far adopted have proved to be resolutive. A current scientific challenge remains the identification of effective strategies improving the endogenous skeletal muscle regenerative program. Read More

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http://dx.doi.org/10.3390/ijms20030683DOI Listing
February 2019

Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M.

Cells 2019 Feb 5;8(2). Epub 2019 Feb 5.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, L8S 4L8, Canada.

The accumulation of extracellular matrix in lung diseases involves numerous factors, including cytokines and chemokines that participate in cell activation in lung tissues and the circulation of fibrocytes that contribute to local fibrotic responses. The transient overexpression of the gp130 cytokine Oncostatin M can induce extracellular matrix (ECM) accumulation in mouse lungs, and here, we assess a role for IL-13 in this activity using gene deficient mice. The endotracheal administration of an adenovirus vector encoding Oncostatin M (AdOSM) caused increases in parenchymal lung collagen accumulation, neutrophil numbers, and CXCL1/KC chemokine elevation in bronchioalveolar lavage fluids. Read More

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http://dx.doi.org/10.3390/cells8020126DOI Listing
February 2019