413,428 results match your criteria Circulation journal : official journal of the Japanese Circulation Society[Journal]


Middle Meningeal Artery to Premeatal Anterior Inferior Cerebellar Artery Bypass Via Anterior Petrosectomy: An Anatomic Feasibility Study.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, University of California, San Francisco, California, USA; Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA. Electronic address: http://skullbaselab.ucsf.edu.

Introduction: Anterior-inferior cerebellar artery (AICA) aneurysms are rare with no optimal consensus on management strategies. When the treatment requires parent artery occlusion post-operative ischemic or neuropathic, complications can occur.

Objective: To evaluate the feasibility of direct revascularization of premeatal AICA using the middle meningeal artery (MMA) as the donor through an anterior petrosectomy (APA) window. Read More

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December 2018

Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle.

Eur J Pharm Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

The aim of this study was to identify critical steps to protein stability during spray drying using two different nozzle types: a vibrating mesh nozzle and a standard two-fluid nozzle in a Büchi B-90 spray dryer. l-Lactic dehydrogenase was used as a model protein as it is a heat and shear stress sensitive protein. Trehalose was used as excipient because of its excellent stabilizing capacities. Read More

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December 2018

Polyethylene glycol-decorated doxorubicin/carboxymethyl chitosan/gold nanocomplex for reducing drug efflux in cancer cells and extending circulation in blood stream.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea. Electronic address:

Polyethylene glycol (PEG)-decorated doxorubicin (Dox)/carboxymethyl chitosan (CMC)/gold nanoparticles (AuNPs) have been developed for cancer therapy. CMC was used as a reducing and stabilizing agent for the fabrication of AuNPs and Dox was loaded onto AuNPs as a chemotherapeutic agent. Dox-loaded CMC-stabilized AuNPs (Dox/CMC-AuNPs) with a mean diameter of 104. Read More

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December 2018
4 Reads

A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.

Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Arboviruses represent a group of pathogens that can spread efficiently throughout human populations by hematophagous arthropod vectors. The mosquito-borne (re)emerging Chikungunya and Dengue viruses belong to the alphavirus and flavivirus genus, respectively, with no approved therapeutics or safe vaccines for humans. Transmitted by the same vector Aedes spp. Read More

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December 2018
1 Read

PEG-grafted phospholipids in vesicles: Effect of PEG chain length and concentration on mechanical properties.

Chem Phys Lipids 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. Electronic address:

Incorporation of low molecular weight poly-ethylene glycol (PEG) - grafted phospholipids in vesicle bilayers is known to increase the circulation time of liposomal drug delivery vehicles. Mechanical properties of giant unilamellar DPPC vesicles containing varying concentrations of DSPE-PEG (PEG MW: 550, 1000 and 2000) were measured by micropipette aspiration assay or osmotic swelling. While the area compressibility modulus did not change significantly, the bending modulus and water permeability of the bilayer was found to increase with increasing mole fraction of DSPE-PEG. Read More

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December 2018

Association of colorectal polyps and cancer with low-dose persistent organic pollutants: A case-control study.

PLoS One 2018 6;13(12):e0208546. Epub 2018 Dec 6.

Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Low-dose persistent organic pollutants (POPs) have recently been linked to immunosenescence, a key mechanism in carcinogenesis, as well as many aging-related chronic diseases. Since feces are the main excretion route of POPs, the large intestine is a potential target organ for these pollutants. We performed a case-control study to evaluate whether exposure to low-dose POPs is related to the risk of colorectal polyps and cancer. Read More

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December 2018

Plasma donor-derived cell-free DNA kinetics after kidney transplantation using a single tube multiplex PCR assay.

PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.

Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.

Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.

Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More

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December 2018

Antibody-assisted delivery of a peptide-drug conjugate for targeted cancer therapy.

Mol Pharm 2018 Dec 6. Epub 2018 Dec 6.

A number of cancer-targeting peptide-drug conjugates (PDCs) have been explored as alternatives to antibody-drug conjugates (ADCs) for targeted cancer therapy. However, the much shorter circulation half-life of PDCs compared with ADCs in vivo has limited their therapeutic value and thus their translation into the clinic, highlighting the need to develop new approaches for extending the half-life of PDCs. Here, we report a new strategy for targeted cancer therapy of a PDC based on a molecular hybrid between an anti-hapten antibody and a hapten-labeled PDC. Read More

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December 2018
3 Reads

Graphene Quantum Dots-Mediated Theranostic Penetrative Delivery of Drug and Photolytics in Deep Tumors by Targeted Biomimetic Nanosponges.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

Dual targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects and improve the unique features required for precision medicine. To realize this aim, however, the hybrids which are often rapidly removal from circulation and piled up tumors periphery near the blood vessels must address the difficulties in low blood half-lives and tumor penetration. In this study, a sponge-inspired carbon composites-supported red blood cell (RBC) membrane that doubles as a stealth agent and photolytic carrier that transports tumor-penetrative agents (graphene quantum dots and docetaxel (GQD-D)) and heat with irradiation was developed. Read More

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December 2018

Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Heretofore, conjugated polymers (CPs) attract considerable attention in photothermal therapy (PTT). Although various CPs with different structures have been reported, the suboptimal circulation persistence and biodistribution limit their efficacy in tumor treatment. Human serum albumin (HSA), an endogenous plasm protein, has been widely functioned as a carrier for therapeutic agents. Read More

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December 2018

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ultrasound Diagnosis, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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December 2018

Abstract 79: Chronic and Acute Hypertension in Ischemic Stroke Are Distinct Markers of Impaired Collateral Circulation.

Stroke 2018 Jan;49(Suppl_1):A79

Univ of Vermont, Burlington, VT.

Background: Acute blood pressure (BP) elevation in acute ischemic stroke (AIS) is common, yet the link with collateral circulation remains elusive due to lack of longitudinal data on premorbid hypertension (HTN) and serial BP changes within an individual. Precision medicine for AIS and management of HTN requires an understanding of collateral circulation.

Methods: The Interventional Management of Stroke III angiography core lab prospectively evaluated collateral circulation utilizing the ASITN scale prior to endovascular therapy. Read More

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January 2018
1 Read

Metabolomics study on promoting blood circulation and ameliorating blood stasis: investigating the mechanism of Angelica sinensis and its processed products.

Biomed Chromatogr 2018 Dec 5:e4457. Epub 2018 Dec 5.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, PR China.

Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG (CDG) were main processed products of DG, which were used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on a rats acute BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Read More

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December 2018

Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke.

Angiogenesis 2018 Dec 5. Epub 2018 Dec 5.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 6309 MBRB, Chapel Hill, NC, 27599-7545, USA.

Vascular dysfunction contributes to the progression and severity of Alzheimer's disease (AD). Patients with AD also sustain larger infarctions after ischemic stroke; however, the responsible mechanisms are unknown. Pial collaterals are the primary source of protection in stroke. Read More

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December 2018

Profound bilateral post-partum retinal circulation ischemia in two diabetic mothers with pre-eclampsia.

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

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West Nile virus in Algeria: a comprehensive overview.

New Microbes New Infect 2019 Jan 21;27:9-13. Epub 2018 Oct 21.

UMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée-Infection, Marseille, France.

West Nile virus (WNV) is a mosquito-borne virus belonging to the genus related to the Japanese encephalitis antigenic complex of family. It is transmitted by the bite of infected mosquitoes. The virus is maintained in a mosquito-bird-mosquito transmission cycle. Read More

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January 2019
2 Reads

Preliminary insights into the genetics of bank vole tolerance to Puumala hantavirus in Sweden.

Ecol Evol 2018 Nov 26;8(22):11273-11292. Epub 2018 Oct 26.

CBGP, INRA, CIRAD, IRD, Montpellier SupAgro Univ. Montpellier Montpellier France.

Natural reservoirs of zoonotic pathogens generally seem to be capable of tolerating infections. Tolerance and its underlying mechanisms remain difficult to assess using experiments or wildlife surveys. High-throughput sequencing technologies give the opportunity to investigate the genetic bases of tolerance, and the variability of its mechanisms in natural populations. Read More

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November 2018

Transient Anarthria and Quadriplegia in a Patient with Basilar Artery Hypoplasia and Coincidental Intracranial Lipoma: A Case Report.

Case Rep Neurol 2018 Sep-Dec;10(3):322-327. Epub 2018 Nov 14.

Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Cerebral ischemia may be rarely associated with a hypoplastic vertebrobasilar system. Intracranial lipoma is also a very rare congenital malformation. We report the case of a 52-year-old woman with vertebrobasilar transient ischemic attack associated with basilar artery hypoplasia and coincidental intracranial lipoma. Read More

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November 2018
1 Read

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation.

J Pain Res 2018 13;11:2809-2819. Epub 2018 Nov 13.

InterVivo Solutions Inc, Toronto, ON, Canada.

Purpose: Prescription and OTC non-steroidal anti-inflammatory drugs (NSAIDs) are ubiquitous treatments for pain and inflammation; however, oral administration of these drugs may produce gastrointestinal (GI) side effects. Transdermal (TD) administration of NSAIDs circumvents these adverse events by avoiding the GI tract and, presumably, achieves regional drug levels of therapeutic effect and thereby, fewer off-target complications.

Methods: A drug quantification method was developed for ibuprofen and celecoxib in canine plasma and synovial fluid using liquid chromatography and mass spectrometry. Read More

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November 2018

Complex mammalian-like haematopoietic system found in a colonial chordate.

Nature 2018 Dec 5. Epub 2018 Dec 5.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life. Although there have been comprehensive studies on self-renewal, differentiation, physiological regulation and niche occupation in vertebrate HSCs, relatively little is known about the evolutionary origin and niches of these cells. Read More

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December 2018
2 Reads

p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton.

Cell Death Dis 2018 Dec 5;9(12):1183. Epub 2018 Dec 5.

Instituto de Biomedicina (IBIOMED) and Departamento de Biología Molecular, Universidad de León, Campus de Vegazana, 24071, León, Spain.

Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct cerebrospinal fluid circulation. Thus, PCP disruption results in ciliopathies and hydrocephalus. Read More

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December 2018
1 Read

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.

Nat Commun 2018 Dec 5;9(1):5191. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, Duke University, Durham, 27710, USA.

The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells produce factors that promote osteoblast differentiation of old bone marrow stromal cells. Heterochronic parabiosis exploiting young mice in which macrophages can be depleted and fractionated bone marrow transplantation experiments show that young macrophages rejuvenate fracture repair, and old macrophage cells slow healing in young mice. Read More

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December 2018
10.742 Impact Factor

Zhongfenggao protects brain microvascular endothelial cells from oxygen-glucose deprivation/reoxygenation-induced injury by angiogenesis.

Biol Pharm Bull 2018 Dec 5. Epub 2018 Dec 5.

Department of encephalopathy, Gansu Provincial Hospital of Traditional Chinese Medicine.

Zhongfenggao (ZFG) is prescribed for the treatment of cerebrovascular diseases in critical projects of the State Administration of Traditional Chinese Medicine. ZFG has been found to nourish qi, activate blood circulation, remove blood stasis, dredge collaterals, and strengthen the brain and mind. The present study investigated the effects of ZFG on oxygen-glucose deprivation/reoxygenation (OGD/R) induced injury to brain microvascular endothelial cells (BMECs), and the mechanisms underlying such effects. Read More

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December 2018

First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies.

Vet Res 2018 Dec 5;49(1):118. Epub 2018 Dec 5.

Unité de Virologie et Immunologie Moléculaires, INRA, Université Paris-Saclay, 78350, Jouy-en-Josas, France.

The presence of pneumoviruses in pigs is poorly documented. In this study, we used the published sequence of the nucleoprotein (N) of the recently identified Swine Orthopneumovirus (SOV) to express and purify SOV N as a recombinant protein in Escherichia coli. This protein was purified as nanorings and used to set up an enzyme-linked immunosorbent assay, which was used to analyse the presence of anti-pneumovirus N antibodies in swine sera. Read More

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December 2018
1 Read

Epidemiological features and spatial clusters of hand, foot, and mouth disease in Qinghai Province, China, 2009-2015.

BMC Infect Dis 2018 Dec 5;18(1):624. Epub 2018 Dec 5.

Institute for Infectious Disease Control and Prevention, Qinghai Provincial Center for Disease Control and Prevention, Xining, Qinghai, China.

Background: Hand, Foot, and Mouth Disease (HFMD) is most frequently caused by Enterovirus71 (EV-A71) or Coxsackie virus A16 (CV-A16), infants and young children are at greatest risk. Describing the epidemiology of HFMD can help develop and better target interventions, including the use of pediatric EV-A71 vaccination.

Methods: We obtained data from the national surveillance system for HFMD cases with onset dates from 2009 to 2015. Read More

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December 2018
2 Reads

Diagnostic and prognostic value of the optic nerve sheath diameter with respect to the intracranial pressure and neurological outcome of patients following hemicraniectomy.

BMC Neurol 2018 Dec 5;18(1):199. Epub 2018 Dec 5.

Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou City, 310009, Zhejiang Province, China.

Background: In cases showing cerebrospinal fluid (CSF) redistribution as a compensatory mechanism in acute intracranial hypertension, the optic nerve sheath diameter (ONSD) can be used to estimate intracranial pressure (ICP). However, it remains unclear whether the ONSD can be applied in patients with skull defects after a craniectomy, because the primary injury or surgical craniectomy may alter the dynamics of the CSF circulation or structure of the optical nerve sheath. This study explored the value of the ONSD in patients after a hemicraniectomy. Read More

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December 2018

Growth Behavior of Human Adipose Tissue-Derived Stromal/Stem Cells at Small Scale: Numerical and Experimental Investigations.

Bioengineering (Basel) 2018 Dec 4;5(4). Epub 2018 Dec 4.

Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences, 8820 Wädenswil, Switzerland.

Human adipose tissue-derived stromal/stem cells (hASCs) are a valuable source of cells for clinical applications, especially in the field of regenerative medicine. Therefore, it comes as no surprise that the interest in hASCs has greatly increased over the last decade. However, in order to use hASCs in clinically relevant numbers, in vitro expansion is required. Read More

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December 2018
1 Read

Hydrodynamic Aspects at Vitória Bay Mouth, ES.

An Acad Bras Cienc 2014 Jun;86(2):555-570

Departamento de Oceanografia e Ecologia, Universidade Federal do Espírito Santo, Goiabeiras, ES, Brasil.

Understading the hydrodynamic behavior and suspended particulated matter (SPM) transport are of great importance in port regions such as Vitória Harbor, which is located at Vitória Bay, Vitória - ES, Brazil. Vitória Bay is an estuary that has not been systematically assessed through a temporal analysis in order to identify its hydrodynamics characteristics and SPM exchange. This study aims to investigate salt and suspended particulate matter flux at the estuarine mouth of Vitória Bay by understanding the temporal variation of salinity, temperature and tidal currents within the water column and at the channel crosssection. Read More

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June 2014
1 Read

Glutamate Supply and Metabolism in Infants.

Ann Nutr Metab 2018 3;73 Suppl 5:29-35. Epub 2018 Dec 3.

Glutamate (Glu) is the most abundant amino acid (AA) in human milk. Available information on Glu supply and metabolism was reviewed, based on an electronic literature search. In 22 cross-sectional global studies with 4,747 women, free Glu increases with lactation duration and contributes to about 38% of total and 63% of dispensable milk AA. Read More

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December 2018

Metabolism of Dietary Glutamate in Adults.

Authors:
Luc Cynober

Ann Nutr Metab 2018 3;73 Suppl 5:5-14. Epub 2018 Dec 3.

Clinical Chemistry Department, Cochin Hospital, AP-HP, Paris,

Background: Glutamate is a non-essential amino acid at the crossroads of nitrogen and energy metabolism. Glutamate metabolism is characterized by reactions that may be anabolic or catabolic in nature depending on the tissue (i.e. Read More

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December 2018
2 Reads

Endocardial transvenous pacing in patients with surgically palliated univentricular hearts: A review on different techniques, problems and management.

Indian Pacing Electrophysiol J 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatric Cardiology, Madras Medical Mission, Chennai, India. Electronic address:

Fontan surgery and its modifications have improved survival in various forms of univentricular hearts. A regular atrial rhythm with atrioventricular synchrony is one of the most important prerequisite for the long-term effective functioning of this preload dependent circulation. A significant proportion of these survivors need various forms of pacing for bradyarrhythmias, often due to sinus nodal dysfunction and sometimes due to atrioventricular nodal block. Read More

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November 2018

Long-Term Performance of a Pneumatically Actuated Soft Pump Manufactured by Rubber Compression Molding.

Soft Robot 2018 Dec 1. Epub 2018 Dec 1.

1 Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering , ETH Zurich, Zurich, Switzerland .

We present a long-term performance study on a pneumatically actuated soft pump (SP). The pump was manufactured by adapting rubber compression technology. Important parameters influencing pump performance (e. Read More

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December 2018

Increased Hematocrit Due to Electrical-Waveform Exposures in Splenectomized Sus scrofa.

J Forensic Sci 2018 Dec 3. Epub 2018 Dec 3.

Bioeffects Division, Airman Systems Directorate, 711th Human Performance Wing, U.S. Air Force Research Laboratory, Joint Base San Antonio, Fort Sam Houston, Texas, 78234.

In laboratory studies of the pig Sus scrofa, hematocrit has consistently increased after conducted-electrical-weapon (CEW) exposures, possibly due to contraction of the spleen. Splenectomized animals and intact sham control animals were exposed, each for 30 sec, to a benchtop-produced electrical waveform of net charge levels similar to those of some CEWs. Changes in the blood were compared statistically. Read More

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December 2018

Detection of Apoptotic Circulating Tumor Cells Using in vivo Fluorescence Flow Cytometry.

Cytometry A 2018 Dec 3. Epub 2018 Dec 3.

Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205.

Most cancer patients die from metastatic disease as a result of a circulating tumor cell (CTC) spreading from a primary tumor through the blood circulation to distant organs. Many studies have demonstrated the tremendous potential of using CTC counts as prognostic markers of metastatic development and therapeutic efficacy. However, it is only the viable CTCs capable of surviving in the blood circulation that can create distant metastasis. Read More

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December 2018

Epidemiological characteristics and determinants of dengue transmission during epidemic and non-epidemic years in Fortaleza, Brazil: 2011-2015.

PLoS Negl Trop Dis 2018 Dec 3;12(12):e0006990. Epub 2018 Dec 3.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: After being eliminated during the 1950s, dengue reemerged in Brazil in the 1980s. Since then, incidence of the disease has increased, as serotypes move within and between cities. The co-circulation of multiple serotypes contributes to cycles of epidemic and interepidemic years, and a seasonal pattern of transmission is observed annually. Read More

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December 2018

Rationale for vaccination with trivalent or quadrivalent live attenuated influenza vaccines: Protective vaccine efficacy in the ferret model.

PLoS One 2018 3;13(12):e0208028. Epub 2018 Dec 3.

International Institutional Cooperation, Institut national de la santé et de la recherche médicale (INSERM), Paris, France.

Background And Aim: The majority of seasonal influenza vaccines are trivalent, containing two A virus strains (H1N1 and H3N2) and one B virus strain. The co-circulation of two distinct lineages of B viruses can lead to mismatch between the influenza B virus strain recommended for the trivalent seasonal vaccine and the circulating B virus. This has led some manufacturers to produce quadrivalent influenza vaccines containing one strain from each B lineage in addition to H1N1 and H3N2 strains. Read More

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December 2018
3 Reads

Weight cycling and cardiovascular outcome in women with suspected ischemia: A report from the NHLBI-sponsored WISE Study.

PLoS One 2018 3;13(12):e0207223. Epub 2018 Dec 3.

Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, United States of America.

Background: We previously reported in a cross-sectional analysis an adverse relationship between weight cycling and HDL-cholesterol but not angiographic obstructive coronary artery disease (CAD) among women undergoing coronary angiography for suspected ischemia in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE). We now examine the relationship between weight cycling and prospective adverse cardiovascular outcome in this group.

Methods: 795 women enrolled between 1996-2001 in the WISE undergoing coronary angiography for evaluation of suspected ischemia and followed for a median of 6. Read More

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December 2018
2 Reads

Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: A cross-sectional study.

PLoS One 2018 3;13(12):e0207324. Epub 2018 Dec 3.

Clinical Development, Biogen, Cambridge, Massachusetts, United States of America.

Background: Systemic sclerosis (SSc) is characterized by excessive fibrosis throughout the body. This leads to the release of extracellular matrix (ECM) fragments into circulation, where they may be quantified as biomarkers. The objectives were to investigate levels of ECM turnover biomarkers and the diagnostic power of these. Read More

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December 2018

Can Blood Flow be Used to Monitor Changes in Peripheral Vascular Function That Occur in Response to Segmental Vibration Exposure?

J Occup Environ Med 2018 Nov 29. Epub 2018 Nov 29.

Engineering Controls and Technology Branch (Dr Krajnak, Ms Waugh); Biostatistics and Epidemiology Branch (Mr Sarkisian), National Institute for Occupational Safety and Health, Morgantown, West Virginia.

Objectives: Laser Doppler blood flow measurements have been used for diagnosis or detection of peripheral vascular dysfunction. This study used a rat tail model of vibration-induced vascular injury to determine how laser Doppler measurements were affected by acute and repeated exposures to vibration, and to identify changes in the Doppler signal that were associated with the exposure.

Methods: Blood flow was measured immediately after a single exposure to vibration, or before vibration exposure on days 1, 5, 10, 15, and 20 of a 20 days exposure. Read More

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November 2018

Managing Patients With Diabetic Foot Ulcers.

Authors:
Laura Bolton

Wounds 2018 Dec;30(12):380-381

Adjunct Associate Professor, Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Diabetic foot ulcers (DFUs) remain a challenge for clinicians despite decades of study. Clinicians now realize that healing strategies should focus on the patient as well as the ulcer. The search continues for interventions that affected individuals and their care providers can count on to heal and manage these challenging wounds, stopping the dreaded progression to amputation and death. Read More

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December 2018

Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification.

J Proteome Res 2018 Dec 3. Epub 2018 Dec 3.

Cystic fibrosis (CF) is a complex multi-organ disorder that is among the most common fatal genetic diseases benefiting from therapeutic interventions early in life. Newborn screening (NBS) for pre-symptomatic detection of CF currently relies on a two-stage immunoreactive trypsinogen (IRT) and cystic fibrosis transmembrane conductance regulator (CFTR) mutation panel algorithm that is sensitive, but not specific for identifying affected neonates with a low positive predictive value. For the first time, we report the discovery of a panel of CF-specific metabolites from a single 3. Read More

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December 2018

Anesthesia for endovascular treatment in anterior circulation stroke: A systematic review and meta-analysis.

Brain Behav 2018 Dec 3:e01178. Epub 2018 Dec 3.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Endovascular treatment in patients with acute anterior circulation stroke could be performed under either conscious sedation (CS) or general anesthesia (GA). Although several studies have investigated the association between the clinical outcomes and the two anesthesia methods, consensus is lacking.

Methods: PubMed and EMBASE searches were used to select full-text articles comparing the effects of GA and CS on functional outcome and complications in patients with anterior circulation ischemic stroke. Read More

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December 2018

Increased Interleukin-23 Receptor (IL-23R) Expression is Associated with Disease Severity in Acute-on-Chronic Liver Failure.

Liver Int 2018 Dec 2. Epub 2018 Dec 2.

Dept. of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Th17 cells mediated immune response is important in chronic hepatitis B (CHB) infection and inflammation associated diseases, however, little is known about their immunopathogenic role in acute-on-chronic liver failure (ACLF). Interleukin-23 receptor (IL-23R) is essential for the generation of pathogenic Th17 cells, therefore, we aimed to evaluate IL-23R expression and its correlation with disease severity in ACLF.

Methods: Forty two patients with ACLF (HBV and alcohol-related), thirty two with CHB and twenty healthy controls (HC) were studied. Read More

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December 2018

Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study.

JPEN J Parenter Enteral Nutr 2018 Dec 2. Epub 2018 Dec 2.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.

Background: Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions.

Methods: This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery. Read More

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December 2018

Detection of West Nile virus lineage 2 in North-Eastern Spain (Catalonia).

Transbound Emerg Dis 2018 Dec 1. Epub 2018 Dec 1.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Bellaterra, Spain.

In September 2017, WNV lineage 2 was detected in Catalonia (Northern Spain) in northern goshawks by passive surveillance. The phylogenetic analyses showed that it was related to the Central/Southern European strains, evidencing WNV lineage 2 spread to Western Europe. WNV local transmission was later detected in bearded vultures housed at the Wildlife Recovery center where the goshawk was transferred to. Read More

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December 2018
1 Read

Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters.

Pflugers Arch 2018 Dec 1. Epub 2018 Dec 1.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

Alpha-Klotho is a member of the Klotho family consisting of two other single-pass transmembrane proteins: βKlotho and γKlotho; αKlotho has been shown to circulate in the blood. Fibroblast growth factor (FGF)23 is a member of the FGF superfamily of 22 genes/proteins. αKlotho serves as a co-receptor with FGF receptors (FGFRs) to provide a receptacle for physiological FGF23 signaling including regulation of phosphate metabolism. Read More

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December 2018