52,184 results match your criteria Circulation[Journal]


The Occurrence of Acute Cardiovascular Events in Transgender Individuals Receiving Hormone Therapy: Results from a Large Cohort Study.

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology, VU Medical Centre, NETHERLANDS.

In hypogonadal/postmenopausal individuals, hormone therapy has been associated with an increased risk for cardiovascular events (CVEs). A steeply growing population that often receives exogenous hormones are transgender individuals. While transgender individuals hypothetically have an increased risk of CVEs, there is little known about the occurrence of CVEs in this population(1). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038584DOI Listing
February 2019
1 Read

Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients in Scandinavia: 1-Year Follow-Up of the HITTS Randomized, Controlled Study.

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Background: There is no consensus on how, when, or at what intensity exercise should be performed after heart transplantation (HTx). We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in the maintenance state after HTx, but studies have not investigated HIT effects in the de novo HTx state. We hypothesized that HIT could be introduced early after a HTx, and that it could lead to clinically meaningful increases in exercise capacity and health-related quality of life (HRQoL). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036747DOI Listing
February 2019

Cardio-Obstetrics.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005417

St Vincent Heart Center, Indianapolis, IN (M.N.W.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005417DOI Listing
February 2019

Paradigm Shifts in the Treatment of Stable Ischemic Heart Disease.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005388

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia. Cardiovascular Outcomes, Quality, and Evaluative Research Center and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005388DOI Listing
February 2019

Effect of Coronary Anatomy and Myocardial Ischemia on Long-Term Survival in Patients with Stable Ischemic Heart Disease.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005079

Massachusetts Veterans Epidemiology, Research, and Informatics Center (MAVERIC), VA New England Healthcare System, and Division of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine (W.E.B.).

Background The severity of coronary artery disease (CAD) and of ischemia are evaluated to guide therapy, but their relative prognostic importance remains uncertain. Accordingly, we sought to clarify their association with long-term survival in the COURAGE trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation). Methods and Results Survival data from after the original trial period ended was obtained at 15 Veterans Affairs sites and 13 of 18 United States non-Veterans Affairs sites. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005079DOI Listing
February 2019

Efficacy and Safety of Apixaban versus Warfarin in Patients with Atrial Fibrillation and Extremes in Body Weight: Insights from the ARISTOTLE Trial.

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Cardiology, Duke University, Medical Center, Durham, NC.

Background: Guidelines caution against the use of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with extremely high (>120 kg) or low (≤60 kg) body weight due to lack of data in these populations.

Methods: In a post-hoc analysis of ARISTOTLE (n=18,201), a randomized trial comparing apixaban with warfarin for the prevention of stroke in patients with AF, we estimated the randomized treatment effect (apixaban vs. warfarin) stratified by body weight (≤60, >60-120, >120 kg) using a Cox regression model and tested the interaction between body weight and randomized treatment. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037955DOI Listing
February 2019

Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway.

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Nutrition, Sun Yat-sen University, China.

Background: Elevated levels of S-adenosylhomocysteine (SAH), the precursor of homocysteine, are positively associated with the risk of cardiovascular disease, and with development and progression of atherosclerosis. However, the role of SAH in endothelial dysfunction is unclear.

Methods: Apolipoprotein E-deficient ( apoE) mice received dietary supplementation with SAH hydrolase (SAHH) inhibitor adenosine dialdehyde (ADA), or were intravenously injected with a retrovirus expressing SAHH short hairpin RNA (shRNA). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036336DOI Listing
February 2019

Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice using In Vivo Imaging.

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Department of Nephrology and Hypertension, Kawasaki Medical School, Japan.

Background: Sodium glucose cotransporter 2 (SGLT2) inhibitors may reduce kidney hyperfiltration, thereby preventing diabetic kidney disease (DKD) progression, which may in turn reduce cardiovascular risk, including heart failure. However, the mechanisms that regulate renal function responses to SGLT2 inhibition are not yet fully understood. We explored the renal protective effects of SGLT2 inhibition with empagliflozin (Empa), with a focus on glomerular hemodynamic effects and tubuloglomerular feedback (TGF) using in vivo multiphoton microscope (MPM) imaging techniques. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037418DOI Listing
February 2019

Supporting the Crucible of Peer Review.

Authors:
Sunil V Rao

Circ Cardiovasc Interv 2019 Feb;12(2):e007835

The Duke Clinical Research Institute, Durham, NC.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007835DOI Listing
February 2019

Safety and Efficacy of Polymer-Free Drug-Eluting Stents.

Circ Cardiovasc Interv 2019 Feb;12(2):e007311

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (M.C., C.A.P., G.G.S.).

Background Polymer-free drug-eluting stents are based on different technologies for drug binding and release without the use of polymer coatings. It is unknown whether different polymer-free drug-eluting stents are comparable in terms of safety and efficacy profiles. Methods and Results Polymer-free BioFreedom biolimus-eluting stents (BES) and polymer-free Cre8 amphilimus-eluting stents (AES) were investigated in 2 recent multicenter registries including 2320 all-comer patients undergoing percutaneous coronary interventions at 22 Italian centers. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007311DOI Listing
February 2019

Entering a Polymer-Free Era.

Circ Cardiovasc Interv 2019 Feb;12(2):e007676

Piedmont Heart Institute, Atlanta, GA (D.E.K.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007676DOI Listing
February 2019

Abnormal Fractional Flow Reserve in Nonobstructive Coronary Artery Disease.

Circ Cardiovasc Interv 2019 Feb;12(2):e006961

Division of Cardiology, Gifu Heart Center, Japan (S.I., T.K., Y.K., H.M.).

Background The basis of discordance between invasive coronary angiographic (ICA) anatomic stenosis and fractional flow reserve (FFR) is not fully understood. We analyzed coronary computed tomography angiography (CTA) characteristics of ICA-verified nonobstructive lesions in the proximal or midleft anterior descending artery with FFR ≤0.8, that is, anatomy-physiology mismatch. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006961DOI Listing
February 2019
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Expression of Concern

Authors:

Circulation 2019 Jan;139(3):e5-e6

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January 2019

Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction

Circulation 2018 Dec;138(24):2754-2762

Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden

Background: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036220DOI Listing
December 2018

Sequential Monitoring of the Comparative Effectiveness and Safety of Dabigatran in Routine Care.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005173

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (S.S., C.G., J.M.F., M.K., K.F.H.).

Background The increasing availability of electronic healthcare data enables ongoing monitoring of the effectiveness and safety of newly marketed medications. We sought to demonstrate a 5-year prospective monitoring system of dabigatran for stroke prevention that may expedite discovery and allow ongoing evidence development. Methods and Results Between 2011 and 2015, we conducted 9 sequential analyses of dabigatran versus warfarin users in a sequential cohort design in 2 US claims databases. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005173DOI Listing
February 2019

Developing and Testing a Personalized, Evidence-Based, Shared Decision-Making Tool for Stent Selection in Percutaneous Coronary Intervention Using a Pre-Post Study Design.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005139

Division of Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, MO (A.K.C., C.D., E.G., K.J., P.J., J.A.S.).

Background Drug-eluting stents reduce the risk of restenosis in patients undergoing percutaneous coronary intervention, but their use necessitates prolonged dual antiplatelet therapy, which increases costs and bleeding risk, and which may delay elective surgeries. While >80% of patients in the United States receive drug-eluting stents, less than a third report that their physicians discussed options with them. Methods and Results An individualized shared decision-making (SDM) tool for stent selection was designed and implemented at 2 US hospitals. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005139DOI Listing
February 2019

Shared Decision-Making in Revascularization Decisions.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005446

Salt Lake City VA Informatics Decision-Enhancement and Analytic Sciences (IDEAS) Center for Innovation, and Department of Population Health Sciences, University of Utah School of Medicine (A.F.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005446DOI Listing
February 2019

Comparative Safety of Aspiration Thrombectomy Catheters Utilizing Prospective, Active Surveillance of the NCDR CathPCI Registry.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e004666

Comparative Effectiveness Research Institute, Lahey Hospital and Medical Center, Burlington, MA (A.M., S.R., H.S., F.S.R.).

Background Current strategies for ensuring the postmarket safety of medical devices are limited by small sample size and reliance on voluntary reporting of adverse events. Prospective, active surveillance of clinical registries may provide early warnings in the postmarket evaluation of medical device safety but has not been demonstrated in national clinical data registries. Methods and Results The CathPCI DELTA (Data Extraction and Longitudinal Trend Analysis) study was designed to assess the feasibility of prospective, active safety surveillance of medical devices within a national cardiovascular registry. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004666DOI Listing
February 2019

PREPARED Study: A Study of Shared Decision-Making for Coronary Artery Disease.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005244

Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC (W.S.J., Y.L., M.R.P.).

Background Guidelines recommend patient engagement in shared decision-making regarding coronary revascularization, but studies demonstrate poor patient understanding of risks, benefits, and alternatives. Effective strategies are needed to integrate informed patient preferences into clinical care, particularly for patients undergoing diagnostic coronary angiography. Methods and Results We developed a web-based decision aid to educate patients and survey their treatment preferences before angiography. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005244DOI Listing
February 2019

High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Cedars-Sinai Smidt Heart Institute, CA.

Background: Hookah smoking is marketed to youth as a harmless alternative to cigarettes. While cigarette smoking acutely impairs endothelial function, the effect of smoking fruit flavored hookah tobacco is unknown. Because charcoal traditionally is used to heat the hookah tobacco in the waterpipe, hookah smoke delivers tobacco toxicants and nicotine plus charcoal combustion products: not only carbon-rich nanoparticles-oxidants that may destroy nitric oxide and impair endothelial function-but also large amounts of carbon monoxide (CO), a putative vasodilator molecule. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037375DOI Listing
February 2019

Contemporary Discrepancies of Stenosis Assessment by Computed Tomography and Invasive Coronary Angiography.

Circ Cardiovasc Imaging 2019 Feb;12(2):e007720

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (Y.B.S., A.A.-Z., M.R.O., A.L.V., J.B., J.A.C.L., J.M.M.).

Background Ongoing advancements of coronary computed tomographic angiography (CTA) continue to challenge the role of invasive coronary angiography (ICA) as the gold standard for the evaluation of coronary artery disease (CAD). We sought to investigate the diagnostic accuracy of 320-slice CTA for detecting obstructive CAD in reference to ICA and nuclear myocardial perfusion imaging using single-photon emission computed tomography. Methods For the CORE320 study (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion), 381 patients at 16 centers underwent CTA, nuclear myocardial perfusion imaging by single-photon emission computed tomography, and ICA for the evaluation of CAD. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007720DOI Listing
February 2019

Computed Tomography to Replace Invasive Coronary Angiography?

Authors:
Paul Knaapen

Circ Cardiovasc Imaging 2019 Feb;12(2):e008710

Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.008710DOI Listing
February 2019

Chronic Atrial and Ventricular Pacing in the Mouse.

Circ Heart Fail 2019 Feb;12(2):e005655

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (M.S., R.N., D.B., G.Z., B.L.L., A.S., D.I.L., D.A.K.).

Background: The mouse is the most widely used mammal in experimental biology. Although many clinically relevant in vivo cardiac stressors are used, one that has eluded translation is long-term cardiac pacing. Here, we present the first method to chronically simulate and simultaneously record cardiac electrical activity in conscious mobile mice. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005655DOI Listing
February 2019

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.

Circulation 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Biochemistry, Osaka University Graduate School of Medicine, Japan.

Background: Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia has identified a growing number of causative gene mutations. Since the only ultimate treatment for symptomatic bradyarrhythmia has been invasive surgical implantation of a pacemaker, the discovery of novel therapeutic molecular targets is necessary to improve prognosis and quality of life. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036761DOI Listing
February 2019

The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association.

Circulation 2019 Feb 14:CIR0000000000000630. Epub 2019 Feb 14.

Coronary artery disease is prevalent in different causes of out-of-hospital cardiac arrest (OHCA), especially in individuals presenting with shockable rhythms of ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT). The purpose of this report is to review the known prevalence and potential importance of coronary artery disease in patients with OHCA and to describe the emerging paradigm of treatment with advanced perfusion/reperfusion techniques and their potential benefits on the basis of available evidence. Although randomized clinical trials are planned or ongoing, current scientific evidence rests principally on observational case series with their potential confounding selection bias. Read More

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https://www.ahajournals.org/doi/10.1161/CIR.0000000000000630
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http://dx.doi.org/10.1161/CIR.0000000000000630DOI Listing
February 2019
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MG53, a Novel Regulator of KChIP2 and I Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Department of Pathophysiology, Shenzhen University Health Science Center, China.

Background: KChIP2 (K channel interacting protein) is the auxiliary subunit of the fast transient outward K current (I) in heart, and insufficient KChIP2 expression induces I downregulation and arrhythmogenesis in cardiac hypertrophy. Studies have shown muscle-specific mitsugumin 53 (MG53) has promiscuity of function in the context of normal and diseased heart. This study investigates the possible roles of cardiac MG53 in regulation of KChIP2 expression and I and the arrhythmogenic potential in hypertrophy. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.029413DOI Listing
February 2019

Bioprosthetic Aortic Valve Replacement in Nonelderly Adults.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005481

Department of Cardiothoracic Surgery (J.R.G.E., S.A.H., P.G., B.P., G.P., A.J.J.C.B., J.J.M.T.), Erasmus University Medical Center, Rotterdam, The Netherlands.

Background To support decision-making in aortic valve replacement in nonelderly adults, we aim to provide a comprehensive overview of reported outcome after bioprosthetic aortic valve replacement and to translate this to age-specific patient outcome estimates. Methods and Results A systematic review was conducted for papers reporting clinical outcome after aortic valve replacement with currently available bioprostheses in patients with a mean age <55 years, published between January 1, 2000, and January 9, 2016. Pooled reported event rates and time-to-event data were pooled and entered into a microsimulation model to calculate life expectancy and lifetime event risk for the ages of 25, 35, 45, and 55 years at surgery. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005481DOI Listing
February 2019

Correction to: The Need for Speed: Accelerating Quality of Care in Acute Ischemic Stroke.

Authors:

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e000052

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http://dx.doi.org/10.1161/HCQ.0000000000000052DOI Listing
February 2019

Rural-Urban Differences in Stroke Risk Factors, Incidence, and Mortality in People With and Without Prior Stroke.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e004973

Division of General Internal Medicine, Department of Medicine (M.K.K., J.V.T.), University of Toronto, Toronto, Ontario, Canada.

Background Rural residence is associated with stroke incidence and mortality, but little is known about potential rural/urban differences in ambulatory stroke care. Methods and Results We used the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) cohort, created from linked administrative databases from the province of Ontario, Canada, and divided into primary (N=6 207 032) and secondary (N=75 823) prevention cohorts based on the absence or presence of prior stroke. We defined rural communities as those with a population size of ≤10 000 and within each of the primary and secondary prevention cohorts, compared cardiovascular risk factors and care between rural and urban areas. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004973DOI Listing
February 2019

The Journey, Not the Destination.

Authors:
Alina Wilson

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005523

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005523DOI Listing
February 2019

Look at the Valve but Listen to the Patient.

Authors:
Himanshu J Patel

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005498

University of Michigan Frankel Cardiovascular Center, Ann Arbor.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005498DOI Listing
February 2019

Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, PA.

Background: Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of mid-pregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in mid-pregnancy identify not only a subset of women at risk for pregnancy complications, but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036632DOI Listing
February 2019

Stem Cell and Left Ventricular Assist Device Combination Therapy.

Circ Heart Fail 2019 Feb;12(2):e005454

Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Slovenia (G.P., B.V.).

Ventricular assist device (VAD) technology has evolved significantly over the past decades and currently represents one of the most important treatment strategies for patients with advanced chronic heart failure. There is increasing evidence that in selected patients undergoing long-term VAD support, improvement of myocardial structure and function may occur. However, there seems to be a significant discrepancy between structural and functional recovery of the failing myocardium, as only a small fraction of VAD-supported patients demonstrate reverse structural remodeling and eventually reach clinically significant and stable, functional improvement. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005454DOI Listing
February 2019

BOLA3 Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Vascular Medicine Institute, University of Pittsburgh, PA.

Background: Deficiencies of iron-sulfur (Fe-S) clusters, metal complexes that control redox state and mitochondrial metabolism, have been linked to pulmonary hypertension (PH), a deadly vascular disease with poorly defined molecular origins. The BolA Family Member 3 (BOLA3) regulates Fe-S biogenesis, and mutations in BOLA3 result in multiple mitochondrial dysfunction syndrome, a fatal disorder associated with PH. The mechanistic role of BOLA3 in PH remains undefined. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
February 2019

Elevated Plasma Ceramides Are Associated With Antiretroviral Therapy Use and Progression of Carotid Artery Atherosclerosis in HIV Infection.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, UNITED STATES.

Background: Ceramides have been implicated in the pathophysiology of HIV infection and cardiovascular disease (CVD). However, no study, to our knowledge, has evaluated circulating ceramide levels in association with subclinical CVD risk among HIV-infected individuals.

Methods: Plasma levels of four ceramide species (C16:0, C22:0, C24:0 and C24:1) were measured among 398 women (73% HIV+) and 339 men (68% HIV+) without carotid artery plaques at baseline from the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037487DOI Listing
February 2019
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Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations.

Circ Cardiovasc Imaging 2019 Feb;12(2):e007865

Department of Pediatrics, Division of Pediatric Cardiology, Boston Children's Hospital, Harvard Medical School, MA (J.C.L., J.W.N.).

Background Heart size and function in children with single right ventricle (RV) anomalies may be influenced by shunt type at the Norwood procedure. We sought to identify shunt-related differences during early childhood after staged surgical palliations using echocardiography. Methods We compared echocardiographic indices of RV, neoaortic, and tricuspid valve size and function at 14 months, pre-Fontan, and 6 years in 241 subjects randomized to a Norwood procedure using either the modified Blalock-Taussig shunt or RV-to-pulmonary-artery shunt. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375302PMC
February 2019
5.316 Impact Factor

Risks of the American Lifestyle.

Authors:
Todd C Villines

Circ Cardiovasc Imaging 2019 Feb;12(2):e008810

Cardiology Service, Walter Reed National Military Medical Center, Bethesda, MD.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.008810DOI Listing
February 2019

Shunts and the Single Right Ventricle.

Circ Cardiovasc Imaging 2019 Feb;12(2):e008711

Division of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE (D.A.D.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008711DOI Listing
February 2019

Coronary Artery Calcium Progression Among the US and Japanese Men.

Circ Cardiovasc Imaging 2019 Feb;12(2):e008104

Department of Public Health, Shiga University of Medical Science, Otsu, Japan (T.H., A.F., K.M., H.U.).

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008104DOI Listing
February 2019

Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005293

Harrington Heart and Vascular Institute (A.K., R.A.J., S.G.A.-K.), University Hospitals Cleveland Medical Center, OH.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005293DOI Listing
February 2019

Health-Related Quality of Life at 30 Days Among Indian Patients With Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e004980

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.D.H., A.S.B., L.Z., D.M.L.-J.).

Background: Despite a high cardiovascular disease burden, data on patient-reported health status outcomes among individuals with cardiovascular disease in India are limited.

Methods And Results: Between November 2014 and November 2016, we collected health-related quality of life data among 1261 participants in the ACS QUIK trial (Acute Coronary Syndrome Quality Improvement in Kerala). We used a translated, validated version of the Seattle Angina Questionnaire administered 30 days after discharge for acute myocardial infarction, wherein higher scores represent better health status. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375309PMC
February 2019

Sex-Related Differences in Patients Undergoing Thoracic Aortic Surgery: Evidence from the Canadian Thoracic Aortic Collaborative.

Circulation 2019 Feb 13. Epub 2019 Feb 13.

Surgery, London Health Sciences Center, Canada.

Background: Contemporary outcomes following surgical management of thoracic aortic disease have improved; however, the impact of sex-related differences is poorly understood.

Methods: A total of 1653 patients (498 (30.1%) female) underwent thoracic aortic surgery with hypothermic circulatory arrest between 2002 and 2017 in ten institutions of the Canadian Thoracic Aortic Collaborative. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035805DOI Listing
February 2019
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Enterovirus Persistence in Cardiac Cells of Patients Suffering From Idiopathic Dilated Cardiomyopathy is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities.

Circulation 2019 Feb 13. Epub 2019 Feb 13.

Medical and Molecular Virology EA4684, Laboratoire de Virologie médicale et moléculaire, et EA-4684, Hôpital Robert Debré, France.

Background: Group B enteroviruses are common causes of acute myocarditis which can be a precursor of chronic myocarditis and dilated cardiomyopathy (DCM), leading causes of heart transplantation. To date, the specific viral functions involved in the development of DCM remain unclear.

Methods: Total RNA from cardiac tissue of patients suffering from DCM was extracted, and sequences corresponding to the 5' termini of enterovirus RNAs were identified. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035966DOI Listing
February 2019

His Bundle Pacing Themed Issue.

Authors:
Paul J Wang

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e007209

Editor-in-Chief, Circulation: Arrhythmia and Electrophysiology.

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http://dx.doi.org/10.1161/CIRCEP.119.007209DOI Listing
February 2019

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction.

Circ Heart Fail 2019 Feb;12(2):e005131

Department of Cardiovascular Diseases, (A.H.C., M.M.R.), Mayo Clinic, Rochester, MN.

Background: The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure. We sought to investigate the expression of this pathway along with the expression of mitochondrial biogenesis (PGC-1α [peroxisome proliferator-activated receptor-γ coactivator-1α]), dynamics (DRP-1 [dynamin-related protein 1], OPA-1 [optic atrophy 1], and MFN 2 [mitofusin 2]), and oxidative phosphorylation (citrate synthase and electron transport chain complexes) markers and COX IV (cytochrome C oxidase) activity in myocardium from patients with valvular or ischemic heart disease and heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF).

Methods And Results: Subepicardial left ventricular biopsies (10×1×1 mm) were obtained at aortic valve replacement (HFpEF, n=5; and HFrEF, n=4), coronary artery bypass grafting (HFpEF, n=5; and HFrEF, n=5), or left ventricular assist device implantation (HFrEF, n=4). Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005131DOI Listing
February 2019
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