52,522 results match your criteria Circulation[Journal]


HLA-B*54:01 Is Associated With Susceptibility to Kawasaki Disease.

Circ Genom Precis Med 2019 Jan;12(1):e002365

Asan Institute for Life Sciences (Y.-C.K., B.K.S., J.-K.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1161/CIRCGEN.118.002365DOI Listing
January 2019

Contemporary Use of Embolic Protection Devices During Saphenous Vein Graft Intervention.

Circ Cardiovasc Interv 2019 May;12(5):e007636

Department of Medicine, Division of Cardiology, Rocky Mountain Regional VA Medical Center, Aurora, CO (J.A.V., T.J.G., E.J.A., S.W.W.).

Background: Guidelines recommend use of embolic protection devices during percutaneous coronary intervention of saphenous vein grafts, but the use of these devices in contemporary practice is unclear. We thus sought to evaluate the patient characteristics and clinical outcomes associated with embolic protection device use during contemporary saphenous vein graft percutaneous coronary intervention.

Methods And Results: We identified patients undergoing isolated saphenous vein graft percutaneous coronary intervention in the Veterans Affairs Healthcare System from January 2008 to June 2017. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007636DOI Listing

Embolic Protection Devices in Saphenous Vein Graft Intervention.

Circ Cardiovasc Interv 2019 May;12(5):e007879

University of Missouri-Kansas City (D.J.C.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007879DOI Listing

Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women.

Circ Cardiovasc Interv 2019 May;12(5):e007086

Department of Medicine, Duke University Medical Center, Durham, NC (J.A.R., A.K., M.W.K., S.V.R).

Background: SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women), a randomized controlled trial comparing radial and femoral access in women undergoing cardiac catheterization or percutaneous coronary intervention (PCI), was terminated early for lower than expected event rates. Whether this was because of patient selection or better access site practice among trial patients is unknown.

Methods And Results: SAFE-PCI was conducted within the National Cardiovascular Data Registry CathPCI registry. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007086DOI Listing

Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Pathology and Cytology, Göteborg, Sweden.

Background: The actin-binding protein filamin A (FLNA) regulates signal transduction important for cell locomotion, but the role of macrophage-specific FLNA during atherogenesis has not been explored.

Methods: We analyzed FLNA expression in human carotid atherosclerotic plaques by immunofluorescence. We also produced mice with Flna-deficient macrophages by breeding conditional Flna-knockout mice ( Flnao/ ) with mice expressing Cre from the macrophage-specific lysosome M promoter (LC). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039697DOI Listing
April 2019
2 Reads

Cardiac Troponin T and Troponin I in the General Population: Comparing and Contrasting their Genetic Determinants and Associations with Outcomes.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: There is great interest in widening the use of high sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it is not clear whether cardiac troponin T (cTnT) and troponin I (cTnI) are equivalent measures of risk in this setting. We aimed to compare and contrast i) the association of cTnT and cTnI with CVD and non-CVD outcomes, and ii) their determinants in a Genome wide association study (GWAS). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038529DOI Listing

Efficacy and Safety of Firibastat, a First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins A Phase 2, Open-Label, Multicenter, Dose-Titrating Study.

Circulation 2019 Apr 24. Epub 2019 Apr 24.

University of Texas Southwestern Medical Center, Dallas, TX.

Background: Despite existing therapy, successful control of hypertension [HTN] in the United States is estimated at less than 50%. In Blacks, HTN occurs earlier, is more severe, controlled less often and has a higher morbidity and mortality than in Whites. Blacks are also less responsive to monotherapy with angiotensin-I converting enzyme [ACE] inhibitors or angiotensin-II receptor type 1 blockers [ARBs]. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040070DOI Listing

The End of a Never-Ending Story.

Circulation 2019 Apr;139(17):2069-2072

Department of Electrophysiology, Heart Center - University of Leipzig, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039992DOI Listing

Putting the Measurement of Physical Capacity of Older Adults in Its Place.

Circulation 2019 Apr;139(17):2000-2002

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039116DOI Listing

Correction to: A Peculiar Wide Complex Tachycardia.

Authors:

Circulation 2019 Apr;139(17):e890

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http://dx.doi.org/10.1161/CIR.0000000000000693DOI Listing

Highlights From the Circulation Family of Journals.

Authors:

Circulation 2019 Apr;139(17):2064-2068

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041038DOI Listing

Letter by Romaguera et al Regarding Article, "Newer Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease: Meta-Analysis of Randomized Trials".

Circulation 2019 Apr;139(17):2081-2082

Heart Diseases Institute, Hospital de Bellvitge - IDIBELL (Institut d'Investigació Biomédica de Bellvitge), University of Barcelona, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038410DOI Listing

Predicting 30-Day Readmissions in Older Adults With Acute Myocardial Infarction.

Authors:
Michael W Rich

Circ Cardiovasc Qual Outcomes 2019 May;12(5):e005627

Department of Medicine, Division of Cardiology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005627DOI Listing

Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2019 May;12(5):e005320

Leon H. Charney Division of Cardiology, Department of Medicine; Division of Healthcare Delivery Science, Department of Population Health, New York University School of Medicine (J.A.D.).

Background: Early readmissions among older adults hospitalized for acute myocardial infarction (AMI) are costly and difficult to predict. Aging-related functional impairments may inform risk prediction but are unavailable in most studies. Our objective was to, therefore, develop and validate an AMI readmission risk model for older patients who considered functional impairments and was suitable for use before hospital discharge. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005320DOI Listing
May 2019
1 Read

Temporal Trends of Percutaneous Coronary Interventions in Older Adults With Acute Myocardial Infarction.

Circ Cardiovasc Interv 2019 May;12(5):e007812

Sinai Hospital of Baltimore, LifeBridge Health Cardiovascular Institute, MD (M.M.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007812DOI Listing

Possible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects.

Circulation 2019 Apr;139(17):1985-1987

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038881DOI Listing

Consumption of Meat, Fish, Dairy Products, Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409,885 Participants in the Pan-European EPIC Cohort.

Circulation 2019 Apr 22. Epub 2019 Apr 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Background: There is uncertainty about the relevance of animal foods to the etiology of ischemic heart disease (IHD). We examined meat, fish, dairy products and eggs and risk for IHD in the pan-European EPIC cohort.

Methods: A prospective study of 409,885 men and women in nine European countries. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038813DOI Listing

Postinfarction Myocardial Calcifications on Cardiac Computed Tomography.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007023

Division of Cardiovascular Medicine (D.M.A., K.C.S., G.S.D., M.Y., M.N., F.M., F.B.), University of Michigan, Ann Arbor.

Background: Postinfarction ventricular tachycardia (VT) generally involves myocardial fibers surrounded by scar. Calcification of scar tissue has been described, but the relationship between calcifications within endocardial scar and VTs is unclear. The purpose of this study was to assess the prevalence of myocardial calcifications as detected by cardiac computed tomography (CT) and the benefit for mapping and ablation focusing on nontolerated VTs. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.007023DOI Listing

Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and Myocardial Wall Thinning.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007175

Cardiovascular Division, Department of Medicine (J.J., E.L., L.H.N., U.N., S.N., F.P., W.J.M., E.A., R.N.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

Background: Conduction velocity (CV) is an important property that contributes to the arrhythmogenicity of the tissue substrate. The aim of this study was to investigate the association between local CV versus late gadolinium enhancement (LGE) and myocardial wall thickness in a swine model of healed left ventricular infarction.

Methods: Six swine with healed myocardial infarction underwent cardiovascular magnetic resonance imaging and electroanatomic mapping. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.007175DOI Listing

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007280

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (J.M.B., R.K.R., M.J.A.), Mayo Clinic, Rochester, MN.

Background: Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients with sodium channel-mediated type 3 long QT syndrome (LQT3). The potential role of sodium channel blockers in patients with potassium channel-mediated long QT syndrome (ie, LQT1 and LQT2) has not been investigated in detail. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.007280DOI Listing

Role of Calcification in Patients With Healed Infarcts Experiencing Ventricular Tachycardia.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007349

Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCEP.119.007349DOI Listing

Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children: Prevalence, Predictors of Survival, and Implications for Hospital Profiling.

Circulation 2019 Apr 22. Epub 2019 Apr 22.

Mid-America Heart Institute, Kansas City, MO & Division of Cardiology, Department of Internal Medicine, University of Missouri-Kansas City, MO.

Background: Cardiopulmonary resuscitation (CPR) is initiated in hospitalized children with bradycardia and poor perfusion. However, their rate of progression to pulseless cardiac arrest despite CPR, and differences in survival compared with initially pulseless arrest are unknown. We examined the prevalence and predictors of survival of children who progress from bradycardia to pulseless in-hospital cardiac arrest despite CPR. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039048DOI Listing

Yield of Clinical Screening for Hypertrophic Cardiomyopathy in Child First-Degree Relatives: Evidence for a Change in Paradigm.

Circulation 2019 Apr 22. Epub 2019 Apr 22.

Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK; Institute of Cardiovascular Sciences, University College London, UK; Member of ERN GUARD-HEART (European Reference Network for Rare and Complex Diseases of the Heart.

Background: Hypertrophic Cardiomyopathy (HCM) is a heritable myocardial disease with age related penetrance. Current guidelines recommend clinical screening of relatives from the age of 10 years onwards but the clinical value of this approach has not been systematically evaluated.

Methods: Anonymized, clinical data were collected from children referred for family screening between 1994-2017 following diagnosis of HCM in a first-degree relative. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038846DOI Listing

Association of Echocardiographic Parameters of Right Ventricular Remodeling and Myocardial Performance With Modified Task Force Criteria in Adolescents With Arrhythmogenic Right Ventricular Cardiomyopathy.

Circ Cardiovasc Imaging 2019 Apr;12(4):e007693

Department of Pediatrics, Labatt Family Heart Centre (G.E.P., L.G.-W., M.H., M.F., P.C., C.S., W.H., C.-P.S.F., C.M., L.M., R.H., M.K.F.), Hospital for Sick Children, University of Toronto, ON, Canada.

Background: The usefulness of echocardiographic indices, including those already used by modified Task Force Criteria (mTFC), and others such as strain imaging, to identify arrhythmogenic right ventricular cardiomyopathy (ARVC) in adolescence is not well established.

Methods: Echocardiograms from 120 adolescents investigated for ARVC (13±4 years) were retrospectively analyzed. According to the mTFC, patients were classified into definite (n=38), borderline (n=39), or possible (n=43) ARVC. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007693DOI Listing

Association Between Secondary Prevention Medication Use and Outcomes in Frail Older Adults After Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e004942

Division of Geriatrics, University of California, San Francisco and San Francisco VA Medical Center, San Francisco (M.A.S., S.J.L.).

Background Secondary prevention medications are often not prescribed to frail, older adults following acute myocardial infarction, potentially because of the absence of data to support use, perceived lack of benefit, and concern over possible harms. We examined the effect of using more guideline-recommended medications after myocardial infarction on mortality, rehospitalization, and functional decline in the frailest and oldest segment of the US population-long-stay nursing home residents. Methods and Results We conducted a retrospective cohort study of nursing home residents aged ≥65 years using 2007 to 2010 national US Minimum Data Set clinical assessment data and Medicare claims. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.004
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004942DOI Listing
April 2019
1 Read

Massive Pulmonary Artery Aneurysm.

Circ Cardiovasc Imaging 2019 Apr;12(4):e008677

Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, Wisconsin (A.W.H., F.S., S.C.P., A.J.T.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008677DOI Listing
April 2019
1 Read

Left Ventricular Twist Mechanics to Identify Left Ventricular Noncompaction in Childhood.

Circ Cardiovasc Imaging 2019 Apr;12(4):e007805

Department of Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom (J.S., G.D.S., S.K., A.F., C.P., V.B., M.J., J.P., D.S., I.V., S.P., P.D.).

Background: Left ventricular noncompaction cardiomyopathy (LVNC) is associated with poor clinical outcome in childhood. Standard diagnostic criteria are still controversial, especially in young patients. Recent studies in adults demonstrated that left ventricular (LV) twist is abnormal in LVNC, but it has not been investigated in pediatric patients to date. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.118.0078
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http://dx.doi.org/10.1161/CIRCIMAGING.118.007805DOI Listing
April 2019
2 Reads

Twist Mechanics of the Left Ventricle.

Circ Cardiovasc Imaging 2019 Apr;12(4):e009085

Istituto Auxologico Italiano, IRCCS, Dipartimento di Scienze Cardiovascolari, Neurologiche, Metaboliche, Ospedale S. Luca, Milano, Italy.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.009085DOI Listing

Challenge of Early Identification of Arrhythmogenic (Right Ventricular) Cardiomyopathy.

Circ Cardiovasc Imaging 2019 Apr;12(4):e009084

Division of Cardiology, Cardiothoracovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste, Italy.

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.119.0090
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http://dx.doi.org/10.1161/CIRCIMAGING.119.009084DOI Listing
April 2019
1 Read

More or Less Medication: Is One Better than the Other?

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005530

Department of Medicine (Geriatrics) (M.K.A.), Dalhousie University, Halifax, NS.

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.119.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005530DOI Listing
April 2019
1 Read

Clinical and Angiographic Predictors of Patient-Reported Angina 1 Year After Coronary Artery Bypass Graft Surgery.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005119

Northport Veterans Affairs Medical Center, Northport, NY (B.M.C., M.B., A.L.W.S.).

Background: Studies of the relationship between patient self-reported angina symptoms using the Seattle Angina Questionnaire (SAQ) and angiographic findings after coronary artery bypass grafting surgery (CABG) are lacking. Nested within a randomized controlled trial, this prospective observational cohort comparison study aimed to assess which clinical characteristics and angiographic findings are associated with self-reported angina 1 year after CABG.

Methods And Results: Patients from the ROOBY trial (Randomized On/Off Bypass) with protocol-specified 1-year post-CABG coronary angiography and SAQ assessments were included (n=1258). Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005119DOI Listing

Streamlining Evaluation and Management Payment to Reduce Clinician Burden.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005426

American College of Cardiology, Regulatory Affairs, Washington, DC (J.J.V.).

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005426DOI Listing
April 2019
1 Read

The CHAT Trial:Time for a Heart to Heart Talk.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005643

Division of Cardiovascular Diseases, Department of Internal Medicine (J.R.G., B.K.N.), University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478447PMC

In This Issue of the Journal.

Authors:
Robert J Gropler

Circ Cardiovasc Imaging 2019 Apr;12(4):e009162

Editor-in-Chief, Circulation: Cardiovascular Imaging.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.009162DOI Listing

Hearts Donated After Circulatory Death and Reconditioned Using Normothermic Regional Perfusion Can Be Successfully Transplanted Following an Extended Period of Static Storage.

Circ Heart Fail 2019 Apr;12(4):e005364

Division of Cardiovascular Surgery (R.V.P.R., J.S.A., F.Y., M.B.A., N.F., V.B., V.R., M.V.B.), Toronto General Hospital, University Health Network, ON, Canada.

Background: There has been an increased interest in donation after circulatory death (DCD) to expand donor pool for cardiac transplantation. Normothermic regional perfusion (NRP) allows in situ assessment of DCD hearts, allowing only acceptable organs to be procured. We sought to determine if extended cold storage was possible for DCD hearts following NRP and to compare hearts stored using standard cold storage with a novel cardioprotective solution designed for room temperature storage. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005364DOI Listing
April 2019
6 Reads

Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005616

Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (E.S.S., Q.D., H.M.K.).

Background: Mobile health technologies are low cost, scalable interventions with the potential to promote patient engagement and behavior change. We aimed to test whether a culturally sensitive text messaging intervention supporting secondary prevention improves the control of risk factors in patients with coronary heart disease in China.

Methods And Results: In this multicenter, single-blinded randomized controlled trial, 822 patients (mean age, 56. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.119.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005616DOI Listing
April 2019
1 Read

Transplantation of Hearts Donated After Circulatory-Determined Death.

Circ Heart Fail 2019 Apr;12(4):e005991

Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, United Kingdom (M.C.P.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.005991DOI Listing
April 2019
1 Read

Effect of Public Reporting on the Utilization of Coronary Angiography After Out-of-Hospital Cardiac Arrest.

Circ Cardiovasc Interv 2019 Apr;12(4):e007564

Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia (A.S.N., S.A.K., J.G.).

Background: Public reporting of cardiovascular outcomes has been associated with risk aversion for potentially lifesaving procedures and may have spillover effects on nonreported but related procedures.

Methods And Results: A cross-sectional analysis of the utilization of coronary angiography among patients presenting with out-of-hospital cardiac arrest between 2005 and 2011 in states with public reporting of percutaneous coronary intervention outcomes (New York and Massachusetts) versus neighboring states without public reporting of percutaneous coronary intervention outcomes (Delaware, Connecticut, Maine, Vermont, Maryland, and Rhode Island) was performed using the Nationwide Inpatient Sample. We analyzed 50 125 admission records with out-of-hospital cardiac arrest between 2005 and 2011. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007564DOI Listing

Assessment of Long-Term Structural Deterioration of Transcatheter Aortic Bioprosthetic Valves Using the New European Definition.

Circ Cardiovasc Interv 2019 Apr;12(4):e007597

Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Department of Cardiology, FHU REMOD-VHF, France (E.D., A.S., C.T., P.Y.L., G.A., A.C., H.E.).

Background: The durability of transcatheter aortic bioprosthetic valves is a crucial issue, but data are scarce, especially beyond 5 years of follow-up. We aimed to assess long-term (7 years) structural valve deterioration (SVD) and bioprosthetic valve failure of transcatheter aortic bioprosthetic valves.

Methods And Results: Consecutive patients with at least 5-year follow-up available undergoing transcatheter aortic valve implantation from April 2002 to December 2011 in 5 French centers were included. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007597DOI Listing
April 2019
1 Read

Clopidogrel Pharmacogenetics.

Circ Cardiovasc Interv 2019 Apr;12(4):e007811

Peter Munk Cardiac Centre, Heart and Stroke Richard Lewar Centre, University of Toronto, Canada (M.E.F.).

Common genetic variation in CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) *2 and *3 alleles leads to a loss of functional protein, and carriers of these loss-of-function alleles when treated with clopidogrel have significantly reduced clopidogrel active metabolite levels and high on-treatment platelet reactivity resulting in increased risk of major adverse cardiovascular events, especially after percutaneous coronary intervention. The Food and Drug Administration has issued a black box warning advising practitioners to consider alternative treatment in CYP2C19 poor metabolizers who might receive clopidogrel and to identify such patients by genotyping. However, routine clinical use of genotyping for CYP2C19 loss-of-function alleles in patients undergoing percutaneous coronary intervention is not recommended by clinical guidelines because of lack of prospective evidence. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007811DOI Listing
April 2019
3 Reads

Heart Transplantation With Donation After Circulatory Death.

Circ Heart Fail 2019 Apr;12(4):e005517

Department of Cardiovascular Surgery, Inselspital, Bern University Hospital and Department for BioMedical Research, University of Bern, Switzerland (P.N., E.F., M.D., T.P.C., H.T.T.S., S.L.L.).

Heart transplantation remains the preferred option for improving quality of life and survival for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of cardiac grafts has become an obstacle. Increasing organ availability with donation after circulatory death (DCD) may be a promising option to overcome the organ shortage. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005517DOI Listing
April 2019
2 Reads

Letter by Sherrid et al Regarding Article, "Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock".

Circ Cardiovasc Interv 2019 Apr;12(4):e007977

Hypertrophic Cardiomyopathy Program, Leon H. Charney Division of Cardiology (M.V.S., L.R., D.M.), Department of Medicine, New York University School of Medicine.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007977DOI Listing
April 2019
1 Read

Impact of Race and Ethnicity on the Clinical and Angiographic Characteristics, Social Determinants of Health, and 1-Year Outcomes After Everolimus-Eluting Coronary Stent Procedures in Women.

Circ Cardiovasc Interv 2019 Apr;12(4):e006918

Interventional Heart Program, Inova Health System, Inova Heart & Vascular Institute, Falls Church, VA (W.B.).

Background The impact of race/ethnicity on coronary stent outcomes in women is unknown. We compared baseline characteristics, social determinants of health, and 1-year outcomes in female African Americans (AA) and Hispanic/Latinas (HL) versus white women after coronary everolimus-eluting stent implantation in all-comer patients. Methods and Results We pooled 1863 women from the PLATINUM Diversity (n=1057 women) and PROMUS ELEMENT PLUS (n=806 women) postapproval studies, with some overlap in study sites. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
Publisher Site
http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006918DOI Listing
April 2019
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Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts.

Circ Heart Fail 2019 Apr;12(4):e005565

Department of Medicine, Aab Cardiovascular Research Institute (R.M.B., J.K.L., D.M.M., E.M.S.), University of Rochester, NY.

Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility. Cardiac fibrosis arises from a pathological attempt to repair tissue damaged during maladaptive remodeling. Treatment options to block or reverse fibrosis have proven elusive. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005565DOI Listing
April 2019
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