51,483 results match your criteria Circulation[Journal]
Circulation 2018 Jul 30;138(5):548-549. Epub 2018 Jul 30.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Circ Genom Precis Med 2018 Dec;11(12):e002239
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (B.F.V.).
Background: Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits. Read More
Circ Heart Fail 2018 Nov;11(11):e000030
Circ Heart Fail 2018 Nov;11(11):e005459
Department of Cellular and Molecular Medicine, University of Arizona, Tucson.
Circ Cardiovasc Imaging 2018 Dec;11(12):e007653
German Center for Lung Research (DZL), Justus-Liebig University of Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany (B.K., J.W., M.K., H.A.G., F.G., N.W., W.S., R.T.S.).
Background: The use of microscopic computed tomography to assess the key functional parameters of systolic emptying or diastolic filling in small animals has not been previously reported. The aim of the study was to test whether microscopic computed tomography can assess the dynamics of both left ventricle and right ventricle (RV) diastolic filling and systolic emptying in an experimental model of pulmonary arterial hypertension Methods and Results: The Wistar-Kyoto rats were injected subcutaneously with the VEGF (vascular endothelial growth factor)-receptor inhibitor SU5416 (20 mg/kg body weight) and were then exposed to chronic hypoxia (10% oxygen) for 21 days (SU5416-hypoxia) followed by normoxia for an additional 2 weeks. Thereafter, multiphase cine cardiac images were acquired using a microscopic computed tomography scanner in conjunction with a blood-pool iodinated contrast agent. Read More
Circ Cardiovasc Interv 2018 Dec;11(12):e007264
Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain (A.T.-M., D.H.-R., A.V., C.L.-G., M.V., J.M.R.-C., F.M.).
Circulation 2018 11;138(22):2499–2512
Diabetes and Obesity Research Program, University of Helsinki, Finland
Background: Both statins and proprotein convertase subtilisin/
kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these 2 lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of
genetic inhibition of PCSK9, acting as a naturally occurring trial.
Methods: Two hundred twenty-eight circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5359 individuals (2659 on treatment) in the PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) trial at 6 months postrandomization. Read More
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305
Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).
Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006720
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands (E.M.J.P.M., L.J.M.E.v.d.D., E.A.H.L., C.P.T., P.K., N.M.S.d.G.).
Background: Extensiveness of conduction delay and block at the pulmonary vein area (PVA) was quantified in a previous study. We hypothesized that the combination of lines of conduction block with multiple concomitantly entering sinus rhythm wavefronts at the PVA may result in increased arrhythmogenicity and susceptibility to atrial fibrillation (AF).
Methods: Intraoperative high-density epicardial mapping of PVA (N≈450 sites, interelectrode distances: 2 mm) was performed during sinus rhythm in 327 patients (241 male [74%], 67±10 [21-84] years) with and without preoperative AF. Read More
Circ Genom Precis Med 2018 Feb;11(2):e002053
From the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA.
Circ Genom Precis Med 2018 Jun;11(6):e000047
Circ Genom Precis Med 2018 Jan;11(1):e000044
Circulation 2018 Nov;138(19):2076-2078
HCM Institute, Division of Cardiology, Tufts Medical Center, Boston MA (M.S.M., B.J.M.).
Circulation 2018 Nov;138(19):2130-2144
Departments of Cardiothoracic Surgery (D.v.B., H.W., M.J.P., A.B.G., A.E., A.T., L.S., A.N.S., V.N.T., K.J., C.H., Y.J.W.), Stanford University, CA.
Background: Cardiovascular bypass grafting is an essential treatment for complex cases of atherosclerotic disease. Because the availability of autologous arterial and venous conduits is patient-limited, self-assembled cell-only grafts have been developed to serve as functional conduits with off-the-shelf availability. The unacceptably long production time required to generate these conduits, however, currently limits their clinical utility. Read More
Circulation 2018 Nov;138(19):2119-2129
Division of Cardiology (M.L.O., A.C.G., M.J.G., Y.D., J.J.R.), The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania.
Background: The arterial switch operation (ASO) is the gold standard operative correction of neonates with transposition of the great arteries and intact ventricular septum, with excellent operative survival. The associations between patient and surgeon characteristics and outcomes are well understood, but the associations between variation in preoperative care and outcomes are less well studied.
Methods: A multicenter retrospective cohort study of infants undergoing neonatal ASO between January 2010 and September 2015 at hospitals contributing data to the Pediatric Health Information Systems database was performed. Read More
Circulation 2018 Nov;138(19):2104-2105
Department of Cardiac Surgery, Institut Universitaire de Cardiology et Pneumologie de Québec, Québec, Canada.
Circulation 2018 Nov;138(19):2081-2090
Division of Cardiac Surgery (R.V.R., D.Y.T., R.K., R.N., S.E.F.), University of Toronto, Ontario, Canada.
Background: Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial grafts during CABG. Read More
Circulation 2018 Nov;138(19):2079-2080
Peter Munk Cardiac Center, Toronto General Hospital, Ontario, Canada. Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Ontario, Canada (M.E.F.).
Circulation 2018 Nov;138(19):2091-2103
Radiology (M.S.K., N.D., D.M.W.), Michigan Medicine, Ann Arbor.
Background: Immediate open repair of acute type A aortic dissection is traditionally recommended to prevent death from aortic rupture. However, organ failure because of malperfusion syndrome (MPS) might be the most imminent life-threatening problem for a subset of patients.
Methods: From 1996 to 2017, among 597 patients with acute type A aortic dissection, 135 patients with MPS were treated with upfront endovascular reperfusion (fenestration/stenting) followed by delayed open repair (OR). Read More
Circulation 2018 Nov;138(19):2160-2168
University of Oxford, United Kingdom (D.P.T.).
We summarize the evidence on the new strategies for coronary artery bypass grafting (CABG). Hybrid CABG implies surgical grafting of the left anterior descending artery and percutaneous treatment of the other target vessels, with the promise of combining the durable benefits of surgery with the less invasive approach of percutaneous coronary interventions. Robotic CABG and minimally invasive CABG are performed through minimal incision or port access with dedicated equipment and instruments. Read More
Circulation 2018 Nov;138(19):2145-2159
Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA (U.S.T., P.A.G.).
Up to 11% of patients presenting with acute coronary syndromes undergo coronary artery bypass grafting. Guidelines largely recommend a one-size-fits-all preoperative discontinuation period for P2Y receptor blockers to avoid bleeding. These recommendations do not account for highly variable pharmacodynamic responsiveness and for variable recovery of platelet reactivity following discontinuation of P2Y receptor blockers. Read More
Circulation 2018 Nov;138(19):2075
Division of Cardiac Surgery, University of Pennsylvania, Philadelphia (T.J.G.).
Circulation 2018 Nov;138(19):2116-2118
Heart Institute, Cincinnati Children's Hospital Medical Center, OH.
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006754
Weill Cornell Cardiovascular Outcomes Research Group (CORG), Division of Cardiology, Department of Medicine, Weill Cornell Medicine-New York Presbyterian Hospital (J.W.C., J.E.I., G.T., C.F.L., S.M.M., B.B.L., L.K.K.).
Background: Patients undergoing catheter ablation of myocardial infarction-associated ventricular tachycardia (VT) have significant comorbidities that can increase the risks of adverse outcomes. The rates of readmissions after VT ablation are unknown. We sought to examine in-hospital outcomes, costs, and 30-day readmissions after catheter ablation of myocardial infarction-associated VT. Read More
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006714
The Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.N., G.E.D., A.K., R.M.J., G.F.M., W.G.S.).
Background: Percutaneous pericardial access for catheter ablation is associated with a bleeding risk. We sought to elucidate the relation of hemorrhagic and thromboembolic events associated with epicardial procedures to anticoagulation strategy.
Methods: Anticoagulation strategy before and during pericardial access for 355 patients (57±14 years old) who had ventricular arrhythmia mapping and ablation were reviewed. Read More
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006692
Department of Biomedical Engineering, George Washington University, Washington, DC.
Background: Abnormal QT intervals, long QT or short QT, have been epidemiologically linked with sudden cardiac death because of ventricular fibrillation (VF). Consequently, Food and Drug Administration recommends testing all pharmacological agents for QT toxicity as a risk factor for cardiac toxicity. Such tests assess QT/QTc interval, which represents ventricular depolarization and repolarization. Read More
Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006681
Heart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Germany (T.D., K.N., A.B., K.S., E.E., B.P., F.F., A.-K.B., P.H.).
Background: Endoscopically detected thermal esophageal lesions (EDEL) after ablation of atrial fibrillation may be precursors of atrioesophageal fistula and esophageal luminal temperature monitoring has previously failed to decrease thermal damage.
Methods: Sixty-three patients undergoing their first pulmonary vein isolation using radiofrequency point-by-point catheter ablation were prospectively included in the HEAT-AF study (High-Resolution Esophageal Assessment of Esophageal Temperature During Atrial Fibrillation Ablation) and esophageal temperatures were continuously monitored using a novel infrared thermography system (IRTS). Peak esophageal temperature (Tpeak) was correlated to postablation endoscopy results characterizing patients as EDEL positive or negative. Read More
Circulation 2018 Oct;138(18):2071-2072
Son Espases University Hospital, Mallorca, Spain.
Circulation 2018 Oct;138(18):2036-2050
Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the left atrial appendage (LAA) has become very important. The potential deleterious effects of this chamber in patients with atrial fibrillation have led to the development of specific treatments for this structure. It has been established that the LAA is the area where the vast majority of thrombi in nonvalvular atrial fibrillation are formed and that some LAA morphologies may actually facilitate thrombi formation and risk stratification for thromboembolic events in patients with low CHADS-VASc scores. Read More
Circulation 2018 Oct;138(18):2069-2070
Icahn School of Medicine at Mount Sinai, New York, and Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY.
Circulation 2018 Oct;138(18):2073-2074
Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain (B.A.-R., P.S.-B., M.O., A.A., J.T.).
Circulation 2018 Oct;138(18):2064-2066
Departments of Cardiovascular Medicine (J.M., S. Takada, S.K., T.F., H.N., N.K., M.T., A.F., T.Y., T.A.), Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Circulation 2018 Oct;138(18):2061-2063
Department of Internal Medicine, Division of Cardiology (R.V., J.A.J., J.A.d.L., S.R.D), University of Texas Southwestern Medical Center, Dallas.
Circulation 2018 Oct;138(18):1948-1950
Valve Science Center, Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, MN.
Circulation 2018 Oct;138(18):2003-2006
Inserm, UMR-S 1180, Univ. Paris-Sud, Université Paris-Saclay, F-92296, Châtenay-Malabry, France.
Circulation 2018 Oct;138(18):2051-2056
Circulation 2018 Oct;138(18):2057-2060
Department of Cardiovascular Medicine/Heart Rhythm Center, Tokyo Medical and Dental University, Japan.
Circulation 2018 Oct;138(18):2067-2068
Division of Cardiology, Electrophysiology, and Pacing, Queen's University, Kingston General Hospital, Ontario, Canada (A.B.).
Circulation 2018 Oct;138(18):1920-1922
Kupat Holim Meuhedet, Jerusalem District, Israel.
Circulation 2018 Oct;138(18):1917-1919
Department of Molecular Medicine, Sapienza University of Rome, Italy. Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.
Circulation 2018 Aug;138(7):724-726
Department of Medicine I, Medical University of Vienna, Austria (P.A.K., S.E.).
Circulation 2018 Aug;138(7):692-695
Advanced Center for Chronic Diseases, Faculty Chemical and Pharmaceutical Sciences and Faculty of Medicine, University of Chile, Santiago (J.A.R., S.L.).
Circulation 2018 Aug;138(7):663-665
Department of Internal Medicine, Cardiology Division (V.G.Z., J.A.H.).
Circulation 2018 Aug;138(7):743-745
Department of Internal Medicine and Clinical Immunology (C.A., O.B., Y.A.).
Circulation 2018 Aug;138(7):746-748
Cincinnati Children's Hospital, OH (S.B., J.R.D., A.T., N.A., G.R.V.).
Circulation 2018 Aug;138(7):666-668
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (B.L.E.).
Circulation 2018 Aug;138(7):735-742
Cardiovascular Disease Unit, Ospedale Policlinico San Martino IRCCS & Laboratory of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Italy (E.B., M.C., P.A.).
Recent epidemiological analyses suggest that incident cancer may be more common among patients with preexisting heart failure (HF) than in patients without HF. Arguments against this notion have been the increased chance of co-occurrence of 2 high-prevalence conditions and increased tumor detection in patients with HF because of intensified medical observation. However, biological data lend support to the hypothesis that HF is an oncogenic condition. Read More
Circulation 2018 Aug;138(7):727-734
Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology (C.E.H., R.Q., M.J.B., R.S.B., E.D.M., M.C.-A.).
Cardiovascular disease (CVD) and cancer continue to be the 2 leading causes of death in developed countries despite significant improvements in the prevention, screening, and treatment of both diseases. They remain significant public health problems, growing in importance globally. Despite this threat, the fields of cardiology and oncology have been relatively disconnected. Read More
Circulation 2018 Aug;138(8):767-769
Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD (R.S.B., K.N., S.S.M.).
Circulation 2018 Aug;138(8):806-808
University of Cincinnati and Cincinnati Children's Hospital Medical Center, OH (B.D.M., J.D.M.).