51,483 results match your criteria Circulation[Journal]


Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease.

Circ Genom Precis Med 2018 Dec;11(12):e002239

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (B.F.V.).

Background: Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits. Read More

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December 2018

Linking Clinical Parameters and Genotype in Dilated Cardiomyopathy.

Authors:
Jared M Churko

Circ Heart Fail 2018 Nov;11(11):e005459

Department of Cellular and Molecular Medicine, University of Arizona, Tucson.

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November 2018

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Circ Cardiovasc Imaging 2018 Dec;11(12):e007653

German Center for Lung Research (DZL), Justus-Liebig University of Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany (B.K., J.W., M.K., H.A.G., F.G., N.W., W.S., R.T.S.).

Background: The use of microscopic computed tomography to assess the key functional parameters of systolic emptying or diastolic filling in small animals has not been previously reported. The aim of the study was to test whether microscopic computed tomography can assess the dynamics of both left ventricle and right ventricle (RV) diastolic filling and systolic emptying in an experimental model of pulmonary arterial hypertension Methods and Results: The Wistar-Kyoto rats were injected subcutaneously with the VEGF (vascular endothelial growth factor)-receptor inhibitor SU5416 (20 mg/kg body weight) and were then exposed to chronic hypoxia (10% oxygen) for 21 days (SU5416-hypoxia) followed by normoxia for an additional 2 weeks. Thereafter, multiphase cine cardiac images were acquired using a microscopic computed tomography scanner in conjunction with a blood-pool iodinated contrast agent. Read More

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December 2018

Bleeding Risk Prediction in Patients With Dual Antiplatelet Therapy Undergoing Coronary Artery Bypass Grafting Surgery Using a Rapid Point-of-Care Platelet Function Test.

Circ Cardiovasc Interv 2018 Dec;11(12):e007264

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain (A.T.-M., D.H.-R., A.V., C.L.-G., M.V., J.M.R.-C., F.M.).

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December 2018

Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Circulation 2018 11;138(22):2499–2512

Diabetes and Obesity Research Program, University of Helsinki, Finland

Background: Both statins and proprotein convertase subtilisin/ kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these 2 lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial.

Methods: Two hundred twenty-eight circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5359 individuals (2659 on treatment) in the PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) trial at 6 months postrandomization. Read More

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November 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018
1 Read

Novel Insights in the Activation Patterns at the Pulmonary Vein Area.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006720

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands (E.M.J.P.M., L.J.M.E.v.d.D., E.A.H.L., C.P.T., P.K., N.M.S.d.G.).

Background: Extensiveness of conduction delay and block at the pulmonary vein area (PVA) was quantified in a previous study. We hypothesized that the combination of lines of conduction block with multiple concomitantly entering sinus rhythm wavefronts at the PVA may result in increased arrhythmogenicity and susceptibility to atrial fibrillation (AF).

Methods: Intraoperative high-density epicardial mapping of PVA (N≈450 sites, interelectrode distances: 2 mm) was performed during sinus rhythm in 327 patients (241 male [74%], 67±10 [21-84] years) with and without preoperative AF. Read More

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November 2018
2 Reads

Revealing Pathways of Cardiac Regeneration.

Circ Genom Precis Med 2018 Feb;11(2):e002053

From the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA.

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February 2018

Case for Earlier Surgical Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy.

Circulation 2018 Nov;138(19):2076-2078

HCM Institute, Division of Cardiology, Tufts Medical Center, Boston MA (M.S.M., B.J.M.).

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November 2018
1 Read

Rapid Self-Assembly of Bioengineered Cardiovascular Bypass Grafts From Scaffold-Stabilized, Tubular Bilevel Cell Sheets.

Circulation 2018 Nov;138(19):2130-2144

Departments of Cardiothoracic Surgery (D.v.B., H.W., M.J.P., A.B.G., A.E., A.T., L.S., A.N.S., V.N.T., K.J., C.H., Y.J.W.), Stanford University, CA.

Background: Cardiovascular bypass grafting is an essential treatment for complex cases of atherosclerotic disease. Because the availability of autologous arterial and venous conduits is patient-limited, self-assembled cell-only grafts have been developed to serve as functional conduits with off-the-shelf availability. The unacceptably long production time required to generate these conduits, however, currently limits their clinical utility. Read More

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November 2018
1 Read

Association Between Variation in Preoperative Care Before Arterial Switch Operation and Outcomes in Patients With Transposition of the Great Arteries.

Circulation 2018 Nov;138(19):2119-2129

Division of Cardiology (M.L.O., A.C.G., M.J.G., Y.D., J.J.R.), The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania.

Background: The arterial switch operation (ASO) is the gold standard operative correction of neonates with transposition of the great arteries and intact ventricular septum, with excellent operative survival. The associations between patient and surgeon characteristics and outcomes are well understood, but the associations between variation in preoperative care and outcomes are less well studied.

Methods: A multicenter retrospective cohort study of infants undergoing neonatal ASO between January 2010 and September 2015 at hospitals contributing data to the Pediatric Health Information Systems database was performed. Read More

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November 2018
1 Read

Upfront Interventional Radiology for Acute Type A Dissection With Malperfusion Syndrome.

Circulation 2018 Nov;138(19):2104-2105

Department of Cardiac Surgery, Institut Universitaire de Cardiology et Pneumologie de Québec, Québec, Canada.

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November 2018
2 Reads

Multiple Arterial Grafting Is Associated With Better Outcomes for Coronary Artery Bypass Grafting Patients.

Circulation 2018 Nov;138(19):2081-2090

Division of Cardiac Surgery (R.V.R., D.Y.T., R.K., R.N., S.E.F.), University of Toronto, Ontario, Canada.

Background: Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial grafts during CABG. Read More

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November 2018
2 Reads

Optimal Treatment of Patients With Left Ventricular Dysfunction and Severe Coronary Artery Disease.

Circulation 2018 Nov;138(19):2079-2080

Peter Munk Cardiac Center, Toronto General Hospital, Ontario, Canada. Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Ontario, Canada (M.E.F.).

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November 2018

Endovascular Fenestration/Stenting First Followed by Delayed Open Aortic Repair for Acute Type A Aortic Dissection With Malperfusion Syndrome.

Circulation 2018 Nov;138(19):2091-2103

Radiology (M.S.K., N.D., D.M.W.), Michigan Medicine, Ann Arbor.

Background: Immediate open repair of acute type A aortic dissection is traditionally recommended to prevent death from aortic rupture. However, organ failure because of malperfusion syndrome (MPS) might be the most imminent life-threatening problem for a subset of patients.

Methods: From 1996 to 2017, among 597 patients with acute type A aortic dissection, 135 patients with MPS were treated with upfront endovascular reperfusion (fenestration/stenting) followed by delayed open repair (OR). Read More

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November 2018
4 Reads

New Strategies for Surgical Myocardial Revascularization.

Circulation 2018 Nov;138(19):2160-2168

University of Oxford, United Kingdom (D.P.T.).

We summarize the evidence on the new strategies for coronary artery bypass grafting (CABG). Hybrid CABG implies surgical grafting of the left anterior descending artery and percutaneous treatment of the other target vessels, with the promise of combining the durable benefits of surgery with the less invasive approach of percutaneous coronary interventions. Robotic CABG and minimally invasive CABG are performed through minimal incision or port access with dedicated equipment and instruments. Read More

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November 2018

Is There a Role for Preoperative Platelet Function Testing in Patients Undergoing Cardiac Surgery During Antiplatelet Therapy?

Circulation 2018 Nov;138(19):2145-2159

Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA (U.S.T., P.A.G.).

Up to 11% of patients presenting with acute coronary syndromes undergo coronary artery bypass grafting. Guidelines largely recommend a one-size-fits-all preoperative discontinuation period for P2Y receptor blockers to avoid bleeding. These recommendations do not account for highly variable pharmacodynamic responsiveness and for variable recovery of platelet reactivity following discontinuation of P2Y receptor blockers. Read More

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November 2018
1 Read

Introduction to the 2018 Cardiovascular Surgery-Themed Issue.

Circulation 2018 Nov;138(19):2075

Division of Cardiac Surgery, University of Pennsylvania, Philadelphia (T.J.G.).

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November 2018

Risk Factors and Biomarkers of Poor Outcomes.

Circulation 2018 Nov;138(19):2116-2118

Heart Institute, Cincinnati Children's Hospital Medical Center, OH.

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November 2018
1 Read

Outcomes, Costs, and 30-Day Readmissions After Catheter Ablation of Myocardial Infarct-Associated Ventricular Tachycardia in the Real World.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006754

Weill Cornell Cardiovascular Outcomes Research Group (CORG), Division of Cardiology, Department of Medicine, Weill Cornell Medicine-New York Presbyterian Hospital (J.W.C., J.E.I., G.T., C.F.L., S.M.M., B.B.L., L.K.K.).

Background: Patients undergoing catheter ablation of myocardial infarction-associated ventricular tachycardia (VT) have significant comorbidities that can increase the risks of adverse outcomes. The rates of readmissions after VT ablation are unknown. We sought to examine in-hospital outcomes, costs, and 30-day readmissions after catheter ablation of myocardial infarction-associated VT. Read More

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November 2018
2 Reads

Complications and Anticoagulation Strategies for Percutaneous Epicardial Ablation Procedures.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006714

The Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.N., G.E.D., A.K., R.M.J., G.F.M., W.G.S.).

Background: Percutaneous pericardial access for catheter ablation is associated with a bleeding risk. We sought to elucidate the relation of hemorrhagic and thromboembolic events associated with epicardial procedures to anticoagulation strategy.

Methods: Anticoagulation strategy before and during pericardial access for 355 patients (57±14 years old) who had ventricular arrhythmia mapping and ablation were reviewed. Read More

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November 2018
6 Reads

Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006692

Department of Biomedical Engineering, George Washington University, Washington, DC.

Background: Abnormal QT intervals, long QT or short QT, have been epidemiologically linked with sudden cardiac death because of ventricular fibrillation (VF). Consequently, Food and Drug Administration recommends testing all pharmacological agents for QT toxicity as a risk factor for cardiac toxicity. Such tests assess QT/QTc interval, which represents ventricular depolarization and repolarization. Read More

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November 2018
2 Reads

High-Resolution Infrared Thermal Imaging of the Esophagus During Atrial Fibrillation Ablation as a Predictor of Endoscopically Detected Thermal Lesions.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006681

Heart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Germany (T.D., K.N., A.B., K.S., E.E., B.P., F.F., A.-K.B., P.H.).

Background: Endoscopically detected thermal esophageal lesions (EDEL) after ablation of atrial fibrillation may be precursors of atrioesophageal fistula and esophageal luminal temperature monitoring has previously failed to decrease thermal damage.

Methods: Sixty-three patients undergoing their first pulmonary vein isolation using radiofrequency point-by-point catheter ablation were prospectively included in the HEAT-AF study (High-Resolution Esophageal Assessment of Esophageal Temperature During Atrial Fibrillation Ablation) and esophageal temperatures were continuously monitored using a novel infrared thermography system (IRTS). Peak esophageal temperature (Tpeak) was correlated to postablation endoscopy results characterizing patients as EDEL positive or negative. Read More

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November 2018
4 Reads

Thrombogenic and Arrhythmogenic Roles of the Left Atrial Appendage in Atrial Fibrillation.

Circulation 2018 Oct;138(18):2036-2050

Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the left atrial appendage (LAA) has become very important. The potential deleterious effects of this chamber in patients with atrial fibrillation have led to the development of specific treatments for this structure. It has been established that the LAA is the area where the vast majority of thrombi in nonvalvular atrial fibrillation are formed and that some LAA morphologies may actually facilitate thrombi formation and risk stratification for thromboembolic events in patients with low CHADS-VASc scores. Read More

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October 2018
4 Reads

Letter by Madias Regarding Article, "Cardiac Arrest With ST-Segment-Elevation in V1 and V2: Differential Diagnosis".

Authors:
John E Madias

Circulation 2018 Oct;138(18):2069-2070

Icahn School of Medicine at Mount Sinai, New York, and Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY.

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October 2018
1 Read

Response by Arroyo Rivera et al to Letters Regarding Article, "Cardiac Arrest With ST-Segment-Elevation in V1 and V2: Differential Diagnosis".

Circulation 2018 Oct;138(18):2073-2074

Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain (B.A.-R., P.S.-B., M.O., A.A., J.T.).

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October 2018

Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure.

Circulation 2018 Oct;138(18):2064-2066

Departments of Cardiovascular Medicine (J.M., S. Takada, S.K., T.F., H.N., N.K., M.T., A.F., T.Y., T.A.), Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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October 2018
5 Reads

Not Too Little and Not Too Late.

Circulation 2018 Oct;138(18):1948-1950

Valve Science Center, Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, MN.

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October 2018
2 Reads

Inhibit a Phosphodiesterase to Treat Heart Failure?

Circulation 2018 Oct;138(18):2003-2006

Inserm, UMR-S 1180, Univ. Paris-Sud, Université Paris-Saclay, F-92296, Châtenay-Malabry, France.

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October 2018
21 Reads

Highlights From the Circulation Family of Journals.

Authors:

Circulation 2018 Oct;138(18):2051-2056

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October 2018

Simultaneous Recording of the P Wave During Atrial Fibrillation.

Circulation 2018 Oct;138(18):2057-2060

Department of Cardiovascular Medicine/Heart Rhythm Center, Tokyo Medical and Dental University, Japan.

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October 2018

Letter by Gottschalk et al Regarding Article, "Cardiac Arrest With ST-Segment-Elevation in V1 and V2: Differential Diagnosis".

Circulation 2018 Oct;138(18):2067-2068

Division of Cardiology, Electrophysiology, and Pacing, Queen's University, Kingston General Hospital, Ontario, Canada (A.B.).

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October 2018
1 Read

Management of Pharyngitis.

Authors:
Jonathan Berkley

Circulation 2018 Oct;138(18):1920-1922

Kupat Holim Meuhedet, Jerusalem District, Israel.

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October 2018
6 Reads

Heart, Spleen, Brain.

Circulation 2018 Oct;138(18):1917-1919

Department of Molecular Medicine, Sapienza University of Rome, Italy. Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.

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October 2018

D-Dimer for Long-Term Risk Prediction in Patients After Acute Coronary Syndrome.

Circulation 2018 Aug;138(7):724-726

Department of Medicine I, Medical University of Vienna, Austria (P.A.K., S.E.).

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August 2018
2 Reads

Heart Disease and Cancer.

Circulation 2018 Aug;138(7):692-695

Advanced Center for Chronic Diseases, Faculty Chemical and Pharmaceutical Sciences and Faculty of Medicine, University of Chile, Santiago (J.A.R., S.L.).

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August 2018
4 Reads

Cardio-Oncology .

Circulation 2018 Aug;138(7):663-665

Department of Internal Medicine, Cardiology Division (V.G.Z., J.A.H.).

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August 2018
2 Reads

CHIP (Clonal Hematopoiesis of Indeterminate Potential).

Circulation 2018 Aug;138(7):666-668

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (B.L.E.).

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Linking Heart Failure to Cancer.

Circulation 2018 Aug;138(7):735-742

Cardiovascular Disease Unit, Ospedale Policlinico San Martino IRCCS & Laboratory of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Italy (E.B., M.C., P.A.).

Recent epidemiological analyses suggest that incident cancer may be more common among patients with preexisting heart failure (HF) than in patients without HF. Arguments against this notion have been the increased chance of co-occurrence of 2 high-prevalence conditions and increased tumor detection in patients with HF because of intensified medical observation. However, biological data lend support to the hypothesis that HF is an oncogenic condition. Read More

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August 2018
3 Reads

Synergistic Opportunities in the Interplay Between Cancer Screening and Cardiovascular Disease Risk Assessment.

Circulation 2018 Aug;138(7):727-734

Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology (C.E.H., R.Q., M.J.B., R.S.B., E.D.M., M.C.-A.).

Cardiovascular disease (CVD) and cancer continue to be the 2 leading causes of death in developed countries despite significant improvements in the prevention, screening, and treatment of both diseases. They remain significant public health problems, growing in importance globally. Despite this threat, the fields of cardiology and oncology have been relatively disconnected. Read More

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August 2018
2 Reads
14.430 Impact Factor

Realizing Value With Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors.

Circulation 2018 Aug;138(8):767-769

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD (R.S.B., K.N., S.S.M.).

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August 2018
4 Reads
14.430 Impact Factor

Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.

Circulation 2018 Aug;138(8):806-808

University of Cincinnati and Cincinnati Children's Hospital Medical Center, OH (B.D.M., J.D.M.).

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