Search our Database of Scientific Publications and Authors

I’m looking for a

    49630 results match your criteria Circulation[Journal]

    1 OF 993

    Incremental Value of Repeated Risk Factor Measurements for Cardiovascular Disease Prediction in Middle-Aged Korean Adults: Results From the NHIS-HEALS (National Health Insurance System-National Health Screening Cohort).
    Circ Cardiovasc Qual Outcomes 2017 Nov;10(11)
    From the Division of Cardiology, Severance Cardiovascular Hospital (I.-J.C., J.M.S., H.-J.C., N.C., H.C.K.), Severance Biomedical Science Institute (H.-J.C.), and Department of Preventive Medicine (H.C.K.), Yonsei University College of Medicine, Seoul, Republic of Korea.
    Background: Increasing evidence suggests that repeatedly measured cardiovascular disease (CVD) risk factors may have an additive predictive value compared with single measured levels. Thus, we evaluated the incremental predictive value of incorporating periodic health screening data for CVD prediction in a large nationwide cohort with periodic health screening tests.

    Methods And Results: A total of 467 708 persons aged 40 to 79 years and free from CVD were randomly divided into development (70%) and validation subcohorts (30%). Read More

    Availability, Sales, and Affordability of Tobacco Cessation Medicines in Kerala, India.
    Circ Cardiovasc Qual Outcomes 2017 Nov;10(11)
    From the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (S. Sarma, A.S.B., M.D.H.); Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India (S.H.); Public Health Foundation of India and Centre for Chronic Disease Control, Gurgaon, Haryana, India (R.D., D.P.); Public Health Foundation of India, Gurgaon, Haryana, India (A.M.); Public Health Foundation of India, Delhi, India (S. Selvaraj); Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA (M.K.A.); and Department of Cardiology, Westfort Hi-Tech Hospital Ltd, Thrissur, Kerala, India (P.P.M.).
    Background: India is the world's second largest consumer of tobacco, but tobacco cessation remains uncommon due, at least in part, to underutilization of cessation pharmacotherapy. We evaluated the availability, sales, and affordability of nicotine replacement therapy, bupropion, and varenicline in the South Indian state of Kerala to understand potential reasons for underutilization.

    Methods And Results: From November 2016 to April 2017, we collected data on availability, inventory, and pricing of cessation medication through a cross-sectional survey of 199 public, semiprivate (Karunya), and private pharmacies across 5 districts in Kerala using World Health Organization/Health Action International methodology. Read More

    Disparities in Management of Cardiovascular Disease in Rural South Africa: Data From the HAALSI Study (Health and Aging in Africa: Longitudinal Studies of International Network for the Demographic Evaluation of Populations and Their Health Communities).
    Circ Cardiovasc Qual Outcomes 2017 Nov;10(11)
    From the Department of Cardiovascular Medicine, Brigham & Women's Hospital, Boston, MA (T.V.J., S.R., T.A.G.); Center for Health Decision Science (T.V.J., S.A.-G., T.A.G.), Department of Global Health and Population (J.S.), and Center for Population and Development Studies (F.X.G.-O.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Chemical Pathology, National Health Laboratory Service and Faculty of Health Sciences (N.J.C.) and Medical Research Council/University of the Witwatersrand Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences (A.W., F.X.G.-O., S.T.), University of the Witwatersrand, Johannesburg, South Africa; International Network for the Demographic Evaluation of Populations and Their Health Network, Accra, Ghana (F.X.G.-O.).
    Background: Optimal secondary prevention is critical for the reduction of repeated cardiovascular events, and the control of cardiovascular risk factors in this context is essential. Data on secondary prevention of cardiovascular disease (CVD) in sub-Saharan Africa are needed to inform intervention strategies with a particular focus on local disparities. The aim of this study was to assess CVD management in a rural community in northeast South Africa. Read More

    Migration and Cardiovascular Disease Risk Among Ghanaian Populations in Europe: The RODAM Study (Research on Obesity and Diabetes Among African Migrants).
    Circ Cardiovasc Qual Outcomes 2017 Nov;10(11)
    From Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (D.B., D.E.G., K.K.-G.); School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana (D.B., P.A.B., E.O.-D.); Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, The Netherlands (C.A., E.B., K.M., K.S.); Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom (L.S., J.A.); Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (M.S., C.G., I.D.); Regional Institute for Population Studies, University of Ghana, Legon, Ghana (A.d.-G.A.); Mother Kevin Postgraduate Medical School, Uganda Martyrs University, Kampala (S.B.); Kumasi Centre for Collaborative Research, Kwame NKrumah University of Science and Technology, Ghana (E.O.-D.); Institute of Tropical Medicine and International Health, Charité-University Medicine Berlin, Germany (F.P.M.); Charite Center for Cardiovascular Research, Berlin, Germany (J.S.); Non-Communicable Disease Research Unit, South African Medical Research Council, Cape Town, South Africa (A.P.K.); and Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (K.K.-G.).
    Background: For migrant populations from sub-Saharan Africa, adverse cardiovascular disease (CVD) risk factors have been observed to be higher than found in their home country-based counterparts or among the host populations in high-income countries. Differences in absolute overall CVD risk, however, remain largely unexplained. We, therefore, predicted the differences in 10-year CVD risk among sub-Saharan African migrants (Ghanaians) living in 3 European cities and Ghana. Read More

    Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure.
    Circ Cardiovasc Qual Outcomes 2017 Nov;10(11)
    From the Department of Medicine, Duke-NUS Medical School, Singapore (Y.M.F.C., C.W.L.C., E.A.F., C.S.P.L.); Department of Cardiology, National Heart Centre Singapore (T.-H.K.T., W.T.T., C.W.L.C., J.Y., C.S.P.L.); School of Population Health, The University of Western Australia, Perth (T.-H.K.T.); Department of Cardiology, National University Heart Centre Singapore (E.S.J.T., A.M.R., L.H.L.); Cardiovascular Research Institute, National University of Singapore (A.M.R., L.H.L., C.S.P.L.); Christchurch Heart Institute, University of Otago, New Zealand (A.M.R.); Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (W.S.); Department of Cardiology, Sejong General Hospital, Bucheon, Korea (S.W.P.); Department of Cardiology, Mackay Memorial Hospital, Taipei, Taiwan (C.-L.H.); Department of Cardiovascular Disease, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (T.N.); National Heart Institute, Institut Jantung Negara, Kuala Lumpur, Malaysia (R.O.); Department of Cardiology, National Cardiovascular Center Universitas Indonesia, Jakarta (B.B.S.); Department of Cardiology, CARE Hospital, Hyderabad, Telangana, India (C.N.); Department of Cardiology, Manila Doctors Hospital, Philippines (E.B.R.); Department of Cardiology, Prince of Wales Hospital, The Chinese University of Hong Kong, The People's Republic of China (C.-M.Y.); Department of Cardiology, Hong Kong Baptist Hospital, The People's Republic of China (C.-M.Y.); Department of Cardiology, VA Medical Center, University of Minnesota, MN (I.A.); Department of Cardiology, Changi General Hospital, Singapore (M.R.M.); and Department of Cardiology, Fuwai Hospital, Beijing, China (S.Z.).
    Background: Implantable cardioverter defibrillators (ICDs) are lifesaving devices for patients with heart failure (HF) and reduced ejection fraction. However, utilization and determinants of ICD insertion in Asia are poorly defined. We determined the utilization, associations of ICD uptake, patient-perceived barriers to device therapy and, impact of ICDs on mortality in Asian patients with HF. Read More

    Long Term Outcomes in Patients with Type 2 Myocardial Infarction and Myocardial Injury.
    Circulation 2017 Nov 17. Epub 2017 Nov 17.
    BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
    Background -Type 2 myocardial infarction and myocardial injury are common in clinical practice, but long-term consequences are uncertain. We aimed to define long-term outcomes and explore risk stratification in patients with type 2 myocardial infarction and myocardial injury. Methods -We identified consecutive patients (n=2,122) with elevated cardiac troponin I concentrations (≥0. Read More

    PCSK9 Variants, LDL-Cholesterol, and Neurocognitive Impairment: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
    Circulation 2017 Nov 16. Epub 2017 Nov 16.
    University of Alabama at Birmingham, Birmingham, AL
    Background -Despite concerns about adverse neurocognitive events raised by prior trials, pharmacologic PCSK9 inhibition was not associated with neurocognitive effects in a recent phase 3 randomized trial. PCSK9 loss-of-function (LOF) variants that result in life-long exposure to low LDL-C can provide information on the potential long-term effects of low LDL-C on neurocognitive impairment and decline. Methods -We investigated the association between PCSK9 LOF variants and neurocognitive impairment and decline among African-American REasons for Geographic and Racial Differences in Stroke (REGARDS) study participants with (n=241) and without (n=10,454) C697X or Y142X LOF variants. Read More

    Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection.
    Circulation 2017 Nov 16. Epub 2017 Nov 16.
    Beijing Anzhen Hospital, Capital Medical University; Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education; Beijing Collaborative Innovation Centre for Cardiovascular Disorders, Beijing, China & Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China
    Background -Misdiagnosis of acute aortic dissection (AAD) can lead to significant morbidity and death. Soluble ST2 (sST2) is a cardiovascular injury-related biomarker. The extent to which sST2 is elevated in AAD and whether sST2 can discriminate AAD from other causes of sudden-onset severe chest pain is unknown. Read More

    Culprit Vessel-Only Versus Multivessel Percutaneous Coronary Intervention in Patients With Cardiogenic Shock Complicating ST-Segment-Elevation Myocardial Infarction: A Collaborative Meta-Analysis.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Department of Medicine, Division of Cardiology, Brown University, Providence, RI (D.K., H.D.A., J.D.A.); Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City (P.S., T.O.); Department of Medicine, Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla (S.K., W.S.A., D.J., J.A.P., W.H.F.); Department of Cardiology, Institut für Herzinfarktforschung Ludwigshafen, Germany (U.Z., M.H.); Department of Cardiology, University Heart Center Lübeck, Medical Clinic II, University Hospital Schleswig-Holstein, Germany (H.T.); German Cardiovascular Research Center (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (H.T.); AMIS Plus Data Center, University of Zurich, Switzerland (D.R., P.E.); Department of Cardiology, Falun Hospital, Sweden (K.H.); Department of Medical Sciences, Uppsala University, Sweden (K.H., S.J.); Department of Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands (B.E.C., J.P.S.H.); Department of Cardiology, Galway University Hospital, SAOLTA Healthcare Group, National University of Ireland (D.M.); Department of Cardiology, Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Hopital Privé Jacques Cartier, Massy, France (P.G.); Department of Medicine, Division of Cardiology, David-Geffen School of Medicine, University of California at Los Angeles (G.C.F.); and Department of Medicine, Division of Cardiology, Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA (D.L.B.).
    Background: The optimal revascularization strategy in patients with multivessel disease presenting with cardiogenic shock complicating ST-segment-elevation myocardial infarction remains unknown.

    Methods And Results: Databases were searched from 1999 to October 2016. Studies comparing immediate/single-stage multivessel percutaneous coronary intervention (MV-PCI) versus culprit vessel-only PCI (CO-PCI) in patients with multivessel disease, ST-segment-elevation myocardial infarction, and cardiogenic shock were included. Read More

    Predictors and Long-Term Clinical Outcome of Longitudinal Stent Deformation: Insights From Pooled Analysis of Korean Multicenter Drug-Eluting Stent Cohort.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Republic of Korea (T.-M.R., K.W.P., H.-J.K., B.-K.K., H.-S.K.); Heart Vascular Stroke Institute, Samsung Medical Center, Seoul, Republic of Korea (J.M.L.); Division of Cardiology, UCLA Medical Center, Los Angeles, CA (M.S.L.); Sejong Heart Institute, Sejong General Hospital, Bucheon, Republic of Korea (K.-H.J.); Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Republic of Korea (J.Y.R.); Department of Internal Medicine, Busan National University Hospital, Republic of Korea (K.S.C.); Department of Internal Medicine, Konyang University Hospital, Daejeon, Republic of Korea (J.-H.B.); Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea (K.-R.H.); Department of Internal Medicine, Ewha Woman's University Mokdong Hospital, Seoul, Republic of Korea (S.-H.P.); Department of Internal Medicine, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea (W.-J.P); Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea (S.-W.R.); Department of Internal Medicine, Wonkwang University Hospital, Iksan, Republic of Korea (S.-K.O.); Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (H.M.K.); Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea (K.-B.S.); Department of Internal Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea (T.A.); and Department of Internal Medicine, Boramae Medical Center, Seoul, Republic of Korea (S.-H.K.).
    Background: There are limited data on the frequency of and factors associated with quantitative coronary angiography (QCA)-defined longitudinal stent deformation (LSD) in various contemporary drug-eluting stents platforms. This study sought to evaluate the predictors of LSD and its long-term clinical implication.

    Methods And Results: A patient-level pooled analysis was performed with 7350 lesions in 5871 patients treated with platinum-chromium-based everolimus-eluting stent (Promus Element), cobalt-chromium-based everolimus-eluting stent (Promus/Xience V), or cobalt-chromium-based zotarolimus-eluting stent (Endeavor Resolute). Read More

    Three-Vessel Assessment of Coronary Microvascular Dysfunction in Patients With Clinical Suspicion of Ischemia: Prospective Observational Study With the Index of Microcirculatory Resistance.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Division of Cardiovascular Medicine, Stanford University, CA (Y.K., W.F.F., T.N., D.-H.C.); Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Seoul, Republic of Korea (J.M.L.); Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea (J.H.L.); Department of Cardiology, Catharina Hospital Eindhoven, the Netherlands (F.M.Z.); Department of Medicine, Seoul National University Hospital, Republic of Korea (J.-H.J., H.-J.L., B.-K.K.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Republic of Korea (E.-S.S.); and Institute of Aging, Seoul National University, Republic of Korea (B.-K.K.).
    Background: Difficulty directly visualizing the coronary microvasculature as opposed to the epicardial coronary artery makes its assessment challenging. The goal of this study is to measure the index of microcirculatory resistance (IMR) in all 3 major coronary vessels to identify the clinical and angiographic predictors of an abnormal IMR.

    Methods And Results: Ninety-three patients who underwent coronary physiological assessment in all 3 major coronary vessels were prospectively enrolled (59. Read More

    Relationships Between Baseline Q Waves, Time From Symptom Onset, and Clinical Outcomes in ST-Segment-Elevation Myocardial Infarction Patients: Insights From the Vital Heart Response Registry.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Canadian VIGOUR Centre (Y.Z., K.R.B., P.W.A., R.C.W.) and Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry (K.R.B., B.D.T., N.B., P.W.A., R.C.W.), University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, Edmonton, Canada (K.R.B., R.C.W.); and CK Hui Heart Centre, Edmonton, Alberta, Canada (B.D.T., N.B.).
    Background: Using a comprehensive ST-segment-elevation myocardial infarction registry, we evaluated the relationships of baseline Q waves, time from symptom onset, and reperfusion strategy with in-hospital clinical outcomes.

    Methods And Results: Consecutive ST-segment-elevation myocardial infarction patients from a defined health region were classified by the presence of baseline Q waves and additionally into primary percutaneous coronary intervention, fibrinolysis, or no reperfusion. ECGs were collected at baseline, after reperfusion, and analyzed for the presence of Q waves using Selvester criteria. Read More

    Percutaneous Left Atrial Appendage Closure: Current Devices and Clinical Outcomes.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Quebec Heart and Lung Institute, Laval University, Quebec City, Canada.
    Chronic oral anticoagulation therapy is the standard therapy for preventing thromboembolic events in patients with atrial fibrillation. However, oral anticoagulation has been associated with an increased risk of bleeding events, and despite the improvements linked to the introduction of direct oral anticoagulants, more than one third of atrial fibrillation patients still remain untreated. Over the past decade, percutaneous left atrial appendage closure has emerged as a valid alternative to anticoagulation therapy for the prevention of stroke/systemic embolism in patients with atrial fibrillation. Read More

    Prognostic Stratification of Patients With ST-Segment-Elevation Myocardial Infarction (PROSPECT): A Cardiac Magnetic Resonance Study.
    Circ Cardiovasc Imaging 2017 Nov;10(11)
    From the Centro Cardiologico Monzino, IRCCS, Milan, Italy (G.P., D.A., M.G., A.B., L.F., S.M., E.C., A.A., A.F., M.E.M., M.V., N.C., G.M., P.A., A.L.B., M.P.); Yonsei University Health System, Seoul, South Korea (G.P.); Department of Emergency and Organ Transplantation, Institute of Cardiovascular Disease, University Hospital Policlinico Consorziale of Bari, Italy (A.I.G.); Department of Medical and Surgical Sciences, University of Foggia, Italy (A.I.G.); Dipartimento di Cardiologia, Policlinico Universitario Paolo Giaccone, Palermo, Italy (G.F., P.C., F.F.); Centro Medico Polispecialistico, Torre Annunziata (Naples), Italy (G.M.); Istituto di Management, Scuola Superiore Sant'Anna, Pisa, Italy (V.L.); Multimodality Cardiac Imaging Section, IRCCS, Policlinico San Donato, Milan, Italy (S.P.); Loyola University of Chicago, IL (M.G.R.); Edward Hines Jr. Veterans Administration Hospital, IL (M.G.R.); Luigi Sacco Department of Biomedical and Clinical Sciences (A.L.B.) and Department of Cardiovascular Sciences and Community Health (D.A., P.A.), University of Milan, Italy; and Division of Cardiology, Centre of Cardiac Magnetic Resonance, University Hospital Lausanne, Switzerland (P.G.M.).
    Background: Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement.

    Methods And Results: Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61. Read More

    A Transcatheter InterAtrial Shunt Device for the Treatment of Heart Failure with Preserved Ejection Fraction (REDUCE LAP-HF I): A Phase 2, Randomized, Sham-Controlled Trial.
    Circulation 2017 Nov 15. Epub 2017 Nov 15.
    Northwestern University Feinberg School of Medicine, Chicago, IL
    Background -In non-randomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), less symptoms, and greater quality of life and exercise capacity in patients with heart failure (HF) and mid-range or preserved ejection fraction (EF ≥ 40%). We conducted the first randomized, sham-controlled trial to evaluate the IASD in HF with EF ≥ 40%. Methods -REDUCE LAP-HF I was a phase 2, randomized, parallel-group, blinded multicenter trial in patients with New York Heart Association (NYHA) class III or ambulatory class IV HF, EF ≥ 40%, exercise PCWP ≥ 25 mmHg, and PCWP-right atrial pressure gradient ≥ 5 mmHg. Read More

    Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled Trial.
    Circulation 2017 Nov 15. Epub 2017 Nov 15.
    Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    Background -We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. Methods -We performed an eighteen-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to iso-caloric low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet+28g walnuts/day with/without added moderate physical activity (PA;80% aerobic; supervised/free gym membership). Read More

    Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events: Result of the Heinz Nixdorf Recall (HNR) Study.
    Circulation 2017 Nov 15. Epub 2017 Nov 15.
    Institute for Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
    Background -Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular (CV) events. Methods -In 3281 participants (45-74 years), free from CV disease until the 2(nd) visit, risk factors and CTs at baseline (b) and after a mean of 5. Read More

    Is There a Sweet Spot for Left Ventricular Assist Devices and Diabetes Mellitus?
    Circ Heart Fail 2017 Nov;10(11)
    From the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, the Kaufman Center for Heart Failure, and the Endocrinology and Metabolism and Heart and Vascular Institutes of the Cleveland Clinic, OH (J.B.Y.); and the Division of Cardiology, The CardioVascular Center, Tufts Medical Center, Boston, MA (A.V.).

    Multicenter Evaluation of Octreotide as Secondary Prophylaxis in Patients With Left Ventricular Assist Devices and Gastrointestinal Bleeding.
    Circ Heart Fail 2017 Nov;10(11)
    From The Pauley Heart Center (K.B.S., S.G., P.A.U., M.L.S.), Department of Pharmacotherapy and Outcomes Research (D.F.B.), and Division of Gastroenterology (G.B.S.), Virginia Commonwealth University, Richmond; Division of Cardiovascular Medicine, The Ohio State University, Columbus (S.E.); McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA (M.K.K.); Division of Cardiology, University of Chicago, IL (N.U.); Division of Cardiology, Columbia University, New York, NY (P.C.C.); and Abbott, Pleasanton, CA (J.C., D.J.F.).
    Background: Gastrointestinal (GI) bleeding is one of the most common complications after continuous-flow left ventricular assist device implantation. More than one third of patients with incident bleed go on to develop recurrent GI bleeding. Octreotide, a somatostatin analog, is proposed to reduce the risk of recurrent GI bleeding in this population. Read More

    Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial).
    Circ Heart Fail 2017 Nov;10(11)
    From the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
    Background: An enhanced inflammatory response predicts worse outcomes in heart failure (HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist (anakinra) could inhibit the inflammatory response and improve peak aerobic exercise capacity in patients with recently decompensated systolic HF.

    Methods And Results: We randomly assigned 60 patients with reduced left ventricular ejection fraction (<50%) and elevated C-reactive protein levels (>2 mg/L), within 14 days of hospital discharge, to daily subcutaneous injections with anakinra 100 mg for 2 weeks, 12 weeks, or placebo. Read More

    Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy.
    Circ Heart Fail 2017 Nov;10(11)
    From the BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (L.S., P.S.J., J.J.V.M.); Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (F.R.); Instituto DAMIC/Fundacion Rusculleda, Cordoba, Argentina (F.M.); Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil (L.C.B.); Grupo de Ciencias Cardiovasculares, Fundación Cardiovascular de Colombia, Santander (L.E.E.); Clinica Shaio, Bogota, Colombia (E.A.G.); Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus (W.T.A.); Stavanger University Hospital, University of Bergen, Norway (K.D.); Rigshospitalet Copenhagen University Hospital, Denmark (L.K.); Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.); Institut de Cardiologie de Montréal, Université de Montréal, Canada (J.L.R.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA (S.D.S.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden (K.S.); National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.); Medical University of South Carolina and Ralph H. Johnson Veterans Administration Medical Center, Charleston (M.R.Z.); and Novartis Pharma, Basel, Switzerland (C.R.G.).
    Background: Chagas' disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas' disease, with other etiologies, in the era of modern HF therapies.

    Methods And Results: This study included 2552 Latin American patients randomized in the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) and ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure) trials. Read More

    Impact of Diabetes Mellitus on Outcomes in Patients Supported With Left Ventricular Assist Devices: A Single Institutional 9-Year Experience.
    Circ Heart Fail 2017 Nov;10(11)
    From the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
    Background: Diabetes mellitus (DM) is a risk factor for morbidity and mortality in patients with heart failure. The effect of DM on post-left ventricular assist device (LVAD) implantation outcomes is unclear. This study sought to investigate whether patients with DM had worse outcomes than patients without DM after LVAD implantation and whether LVAD support resulted in a better control of DM. Read More

    Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome.
    Circ Arrhythm Electrophysiol 2017 Nov;10(11)
    From the Division of Heart Rhythm Services, Department of Cardiovascular Diseases (A.S., P.A.N., V.K., B.Q., Z.I.A., P.B., S.J.A., P.A.F., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (R.K.R., J.M.B., S.J.A., M.J.A.), and Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Windland Smith Rice Sudden Death Genomics Laboratory, and Division of Biomedical Statistics and Informatics (C.G.S.), Mayo Clinic, Rochester, MN; Czech Institute of Informatics, Robotics, and Cybernetics, Czech Technical University in Prague (V.K.); and Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel (Y.S.).
    Background: Although the hallmark of long-QT syndrome (LQTS) is abnormal cardiac repolarization, there are varying degrees of phenotypic expression and arrhythmic risk. Our aim was to evaluate the performance of a morphological T-wave analysis program in defining breakthrough LQTS arrhythmic risk beyond the QTc value.

    Methods And Results: We analyzed 407 genetically confirmed patients with LQT1 (n=246; 43% men) and LQT2 (n=161; 41% men) over the mean follow-up period of 6. Read More

    STABLE-SR (Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm) for the Treatment of Nonparoxysmal Atrial Fibrillation: A Prospective, Multicenter Randomized Clinical Trial.
    Circ Arrhythm Electrophysiol 2017 Nov;10(11)
    From the Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, China (B.Y., G.Y., M.C.); Department of Cardiology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.J.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (Y.L.); Department of Cardiology, Ningbo First Hospital, Zhejiang University, Ningbo, China (H. Chu); Department of Cardiology, General Hospital, Tianjin Medical University, China (H. Cai); Department of Cardiology, Tianjin Chest Hospital, China (F.L.); Department of Cardiology, Guangdong Province People's Hospital, Guangzhou, China (X.Z.); Department of Cardiology, Anhui Provincial Hospital, Hefei, China (J.X.); Department of Cardiology, Renji Hospital, Shanghai Jiaotong University, China (X.W.); Department of Cardiology, National Heart Centre Singapore (C.-K.C.); Department of Electrophysiology and Cardiac Pacing, Medanta, The Medicity Hospital, Gurgaon, Haryana, India (B.S.); and Department of Cardiology, Korea University Hospital, Seoul (Y.-H.K.).
    Background: Circumferential pulmonary vein isolation (CPVI) alone or combined with adjuvant substrate modifications is unsatisfactory for atrial fibrillation (AF) control in nonparoxysmal AF patients. Ablation targeting the fibrotic areas after CPVI (STABLE-SR [Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm]) is a newly evolved substrate modification strategy.

    Methods And Results: In this multicenter, randomized clinical trial, 229 symptomatic nonparoxysmal AF patients were 1:1 randomized to STABLE-SR group (n=114) or conventional STEPWISE group (n=115). Read More

    Treatment of Atrial Fibrillation and Concordance With the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines: Findings From ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation).
    Circ Arrhythm Electrophysiol 2017 Nov;10(11)
    From the Duke Center for Atrial Fibrillation, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (A.S.B., S.K., L.E.T., E.D.P., J.P.P.); Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center (G.C.F.); Columbia University College of Physicians and Surgeons, New York, NY (J.A.R.); University of Colorado School of Medicine, Aurora (L.A.A.); Yale University School of Medicine, New Haven, CT (J.V.F.); Penn State Hershey Heart and Vascular Institute (G.N.); Stanford University School of Medicine, CA (K.W.M.); Kaiser Permanente Division of Research, Oakland, CA (A.S.G.); Lankenau Institute for Medical Research and Jefferson Medical College, Philadelphia, PA (P.R.K.); Hofstra Northwell School of Medicine, New York, NY (J.E.A.); Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN (B.J.G.); and Boston University Medical Center, MA (E.M.H.).
    Background: It is unclear how frequently patients with atrial fibrillation receive guideline-concordant (GC) care and whether guideline concordance is associated with improved outcomes.

    Methods And Results: Using data from ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation), we determined how frequently patients received care that was concordant with 11 recommendations from the 2014 American Heart Association/American College of Cardiology/Heart Rhythm Society atrial fibrillation guidelines pertaining to antithrombotic therapy, rate control, and antiarrhythmic medications. We also analyzed the association between GC care and clinical outcomes at both the patient level and center level. Read More

    Cerebral Oxygenation Measurements by Magnetic Resonance Imaging in Fetuses With and Without Heart Defects.
    Circ Cardiovasc Imaging 2017 Nov;10(11):e006459
    From Pediatrics and Adolescent Medicine, Neonatal and Intensive Care Unit (M.H.L., T.B.H.), Department of Obstetrics and Gynecology (N.U., O.B.P.), Department of Pediatrics, Perinatal Epidemiology Research Unit (T.B.H., N.B.M.), Department of Radiology (B.S.-G.), and Department of Cardio-Thoracic and Vascular Surgery (V.E.H.), Aarhus University Hospital, Denmark; Institute for Clinical Medicine (M.H.L., N.U., S.R., V.E.H.) and the MR Research Centre (S.R.), Aarhus University, Denmark; and Department of Clinical Engineering, Central Denmark Region, Aarhus (D.A.P.).
    Background: Children with major congenital heart defects are risking impaired cerebral growth, delayed cerebral maturation, and neurodevelopmental disorders. We aimed to compare the cerebral tissue oxygenation of fetuses with major heart defects to that of fetuses without heart defects as estimated by the magnetic resonance imaging modality T2*. T2* is low in areas with high concentrations of deoxyhemoglobin. Read More

    ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway.
    Circulation 2017 Nov 14. Epub 2017 Nov 14.
    Emergency Department, Waitakere Hospital, Auckland, New Zealand.
    BACKGROUND : Efforts to safely reduce length of stay for emergency department patients with symptoms suggestive of acute coronary syndrome (ACS) have had mixed success. Few system-wide efforts affecting multiple hospital emergency departments have ever been evaluated. We evaluated the effectiveness of a nationwide implementation of clinical pathways for potential ACS in disparate hospitals. Read More

    Impact of Regionalization of ST Elevation Myocardial Infarction Care on Treatment Times and Outcomes for Emergency Medical Services Transported Patients Presenting to Hospitals with Percutaneous Coronary Intervention: Mission: Lifeline Accelerator-2.
    Circulation 2017 Nov 14. Epub 2017 Nov 14.
    Duke Clinical Research Institute, Duke University, Durham, NC.
    Background: Regional variations in reperfusion times and mortality in patients with ST-segment elevation myocardial infarction (STEMI) are influenced by differences in coordinating care between emergency medical services (EMS) and hospitals. Building on the Accelerator-1 Project, we hypothesized that time to reperfusion could be further reduced with enhanced regional efforts. Methods: Between April 2015 and March 2017, we worked with 12 metropolitan regions across the United States with 132 PCI-capable hospitals and 946 EMS agencies. Read More


    Clinical Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.
    Circ Cardiovasc Interv 2017 Nov;10(11)
    From the Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (Y.A., T.C., W.C., J.S.F., R.R.M.); Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC (S.V., Z.L.); Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, NC (R.A.M.); Department of Surgery, Duke University Medical Center, Durham, NC (A.W.); Heart and Vascular Institute, Cleveland Clinic, OH (S.K.); Division of Cardiology, Mayo Clinic, Rochester, MN (D.H.); University of Texas Memorial Hermann Heart and Vascular Institute, Houston (R.S.); Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA (V.T.); Heart Hospital Baylor Plano, Baylor Healthcare System, TX (M.M.); and Division of Cardiology, Columbia University Medical Center, New York, NY (M.L.).
    Background: Diabetes mellitus (DM) adversely affects morbidity and mortality for cardiovascular diseases and procedures. Data evaluating the outcomes of transcatheter aortic valve replacement (TAVR) in diabetic patients are limited by small sample size and contradictory results. We aimed to establish the magnitude of risk and the incremental influence of insulin dependency by examining short- and long-term adverse outcomes according to DM status and therapy in the world's largest TAVR registry. Read More

    Do We Finally Have the A to Z of Z Scores?
    Circ Cardiovasc Imaging 2017 Nov;10(11)
    From the Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's and St Thomas' NHS Trust, London, UK (J.M.S.); Division of Imaging Sciences and Biomedical Engineering, King's College London, United Kingdom (H.C.); and Department of Paediatric Cardiology, Great Ormond Street Hospital, London, United Kingdom (H.C.).

    Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database.
    Circ Cardiovasc Imaging 2017 Nov;10(11)
    From the Nicklaus Children's Hospital, Miami, FL (L.L.); Boston Children's Hospital, MA (S.C., A.P.); National Heart, Lung, and Blood Institute, Bethesda, MD (M.S., G.P.); New England Research Institutes, Watertown, MA (S.G., F.T.); Children's Hospital of Wisconsin, Milwaukee (P.F., M.F.); Ann & Robert Lurie Children's Hospital, Chicago, IL (J. Camarda); Cincinnati Children's Hospital Medical Center, OH (J. Cnota); Children's Hospital of Philadelphia, PA (M.C.); Hospital for Sick Children, Toronto, ON, Canada (A.D.); Texas Children's Hospital, Houston (O.G., R.P.); Riley Hospital for Children at Indiana University Health, Indianapolis (T.J.); Children's Hospital of Orange County, CA (W.L.); Children's Hospital at Montefiore, Bronx, NY (J.M.); Children's Healthcare of Atlanta, GA (R.S.); Seattle Children's Hospital, WA (B.S.); Vanderbilt University Medical Center, Nashville, TN (J.S.); Children's National Health System, Washington, DC (C.S.); Mount Sinai Medical Center, New York, NY (S.S.); Medical University of South Carolina, Charleston (C.T.); Children's Health Dallas, TX (P.T.); CS Mott Children's Hospital, Ann Arbor, MI (M.v.d.V.); and University of Utah, Salt Lake City (L.M.).
    Background: Published nomograms of pediatric echocardiographic measurements are limited by insufficient sample size to assess the effects of age, sex, race, and ethnicity. Variable methodologies have resulted in a wide range of Z scores for a single measurement. This multicenter study sought to determine Z scores for common measurements adjusted for body surface area (BSA) and stratified by age, sex, race, and ethnicity. Read More

    Head-to-Head Comparison of Global and Regional Two-Dimensional Speckle Tracking Strain Versus Cardiac Magnetic Resonance Tagging in a Multicenter Validation Study.
    Circ Cardiovasc Imaging 2017 Nov;10(11)
    From the Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Service de Cardiologie, Université Catholique de Louvain, Brussels, Belgium (M.S.A., L.B., A.S., C.R., C.d.M., A.P., D.V., A.-C.P., J.-L.J.V., B.L.G.); Philips Clinical Research Board, Paris, France (H.L.); University Hospital of Caen, France (E.S.); EA 4650, Caen University, FHU REMOD-VHF, France (A.M.); and Philips Research, Medical Imaging (Medisys), Suresnes, France (P.A., M.D.C.).
    Background: Despite widespread use to characterize and refine prognosis, validation data of two-dimensional (2D) speckle tracking (2DST) echocardiography myocardial strain measurement remain scarce.

    Methods And Results: Global and regional subendocardial peak-systolic Lagrangian longitudinal (LS) and circumferential strain (CS) by 2DST and 2D-tagged (2DTagg) cardiac magnetic resonance imaging were compared against sonomicrometry in a dynamic heart phantom and among each other in 136 patients included prospectively at 2 centers. The ability of regional LS and CS 2DST and 2DTagg to identify late gadolinium enhancement was compared using receiver operating characteristics curves. Read More

    1 OF 993