83 results match your criteria Circulation: Heart Failure [Journal]


Stem Cell and Left Ventricular Assist Device Combination Therapy.

Circ Heart Fail 2019 Feb;12(2):e005454

Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Slovenia (G.P., B.V.).

Ventricular assist device (VAD) technology has evolved significantly over the past decades and currently represents one of the most important treatment strategies for patients with advanced chronic heart failure. There is increasing evidence that in selected patients undergoing long-term VAD support, improvement of myocardial structure and function may occur. However, there seems to be a significant discrepancy between structural and functional recovery of the failing myocardium, as only a small fraction of VAD-supported patients demonstrate reverse structural remodeling and eventually reach clinically significant and stable, functional improvement. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005454DOI Listing
February 2019
1 Read

Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization.

Circ Heart Fail 2018 Nov;11(11):e005531

Departments of Medicine, ontreal Heart Institute, University of Montreal, Canada (N.B., J.L.R.).

Background: The STICH trial (Surgical Treatment for Ischemic Heart Failure) demonstrated a survival benefit of coronary artery bypass grafting in patients with ischemic cardiomyopathy and left ventricular dysfunction. The Society of Thoracic Surgeons (STS) risk score and the EuroSCORE-2 (ES2) are used for risk assessment in cardiac surgery, with little information available about their accuracy in patients with left ventricular dysfunction. We assessed the ability of the STS score and ES2 to evaluate 30-day postoperative mortality risk in STICH and a contemporary cohort (CC) of patients with a left ventricle ejection fraction ≤35% undergoing coronary artery bypass grafting outside of a trial setting. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309904PMC
November 2018
14 Reads
5.891 Impact Factor

Targeting All Heart Failure Patients With Exercise Training: Is it Safe and Efficacious?

JACC Heart Fail 2018 Dec;6(12):1020-1022

Bremer Institute for Heart and Circulation Research at the Klinikum Links der Weser, Bremen, Germany.

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http://dx.doi.org/10.1016/j.jchf.2018.10.005DOI Listing
December 2018
1 Read

Forgotten No More: A Focused Update on the Right Ventricle in Cardiovascular Disease.

JACC Heart Fail 2018 Nov 10;6(11):891-903. Epub 2018 Oct 10.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California; Stanford Cardiovascular Institute, Stanford, California; Vera Moulton Wall Center at Stanford, Stanford, California. Electronic address:

In the last decade, there has been renewed interest in the study of the right ventricle. It is now well established that right ventricular function is a strong predictor of mortality, not only in heart failure but also in pulmonary hypertension, congenital heart disease, and cardiothoracic surgery. The right ventricle is part of a cardiopulmonary unit with connections to the pulmonary circulation, venous return, atria, and left ventricle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779183053
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http://dx.doi.org/10.1016/j.jchf.2018.05.022DOI Listing
November 2018
5 Reads

Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices.

Circ Heart Fail 2018 Jun;11(6):e004670

Division of Cardiology, Department of Medicine (S.N.P., W.K.C, A.V.A.)

Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole. Although outcomes and durability have improved with CF-LVADs, patients supported with CF-LVADs have a high rate of complications that were not as frequently observed with older pulsatile devices, including gastrointestinal bleeding from arteriovenous malformations, pump thrombosis, and stroke. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007027PMC
June 2018
26 Reads

Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support.

Circ Heart Fail 2018 May;11(5):e004491

Division of Cardiology, Department of Medicine (A.V.A., M.L., S.N.P., K.S.M.).

Background: Coronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD.

Methods And Results: Coronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group). Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941935PMC
May 2018
5 Reads

Apophenia and the Crafting of a Issue.

Authors:
Nancy K Sweitzer

Circ Heart Fail 2018 Mar;11(3):e005027

From the Division of Cardiovascular Medicine, Sarver Heart Center, University of Arizona, Tucson.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005027DOI Listing
March 2018
3 Reads

Hemodynamics of Fontan Failure: The Role of Pulmonary Vascular Disease.

Circ Heart Fail 2017 Dec;10(12)

From the Department of Cardiovascular Medicine (A.C.E., H.M.C., W.R.M., N.M.A., B.A.B.) and Division of Pediatric Cardiology (D.J.H.), Mayo Clinic, Rochester, MN; and Department of Pediatrics, Cincinnati Children's Hospital, OH (B.A.B.).

Background: Nonpulsatile pulmonary blood flow in Fontan circulation results in pulmonary vascular disease, but the potential relationships between pulmonary vascular resistance index (PVRI) and Fontan failure have not been studied. The objective was to determine whether the absence of subpulmonary ventricle in the Fontan circulation would make patients more vulnerable to even low-level elevations in PVRI, and when coupled with low cardiac index, this would identify patients at increased risk of Fontan failure.

Methods And Results: Two hundred sixty-one adult Fontan patients underwent cardiac catheterization; age 26±3 years, men 146 (56%), atriopulmonary Fontan 144 (55%). Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739063PMC
December 2017
9 Reads

Hemodynamic Phenotyping of Pulmonary Hypertension in Left Heart Failure.

Circ Heart Fail 2017 Sep;10(9)

From the Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Brussels, Belgium (R.N., J.-L.V., S.C.); Department of Internal Medicine II, Division of Cardiology, General Hospital of Vienna (AKH-Wien), Medical University of Vienna, Austria (M.G., C.G., I.M.L.); and Department of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano, Milan, Italy (S.C.).

Increased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary hypertension (PH). The diagnosis of PH due to left heart disease relies on a clinical probability assessment followed by the invasive measurements of a mean pulmonary artery pressure (PAP) ≥25 mm Hg and mean wedged PAP (PAWP) >15 mm Hg. A combination of mean PAP and mean PAWP defines postcapillary PH. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004082DOI Listing
September 2017
11 Reads

Intrarenal Flow Alterations During Transition From Euvolemia to Intravascular Volume Expansion in Heart Failure Patients.

JACC Heart Fail 2017 09 12;5(9):672-681. Epub 2017 Jul 12.

Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium; Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Electronic address:

Objectives: The goal of this study was to assess: 1) the intrarenal flow in heart failure (HF) patients during the transition from euvolemia to intravascular volume overload; and 2) the relationship between intrarenal flow and diuretic efficiency.

Background: Intrarenal blood flow alterations may help to better understand impaired volume handling in HF.

Methods: Resistance index (RI) and venous impedance index (VII) were assessed in 6 healthy subjects, 40 euvolemic HF patients with reduced ejection fraction (HFrEF), and 10 HF patients with preserved ejection fraction (HFpEF). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779173033
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http://dx.doi.org/10.1016/j.jchf.2017.05.006DOI Listing
September 2017
5 Reads

The Fastest Way to the Failing Heart Is Through the Kidneys.

JACC Heart Fail 2017 09 12;5(9):682-683. Epub 2017 Jul 12.

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2017.06.001DOI Listing
September 2017
3 Reads

Balancing Bleeding and Clotting: The Known Unknowns of Mechanically Assisted Circulation.

Authors:
Joseph G Rogers

Circ Heart Fail 2017 05;10(5)

From the Division of Cardiology, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004097DOI Listing
May 2017
28 Reads

Extracorporeal Membrane Oxygenation in New York State: Trends, Outcomes, and Implications for Patient Selection.

Circ Heart Fail 2016 12;9(12)

From the Department of Cardiovascular Surgery (J.B., N.T., S.I., J.C.) and Department of Population Health Science and Policy (N.N.E.), Icahn School of Medicine at Mount Sinai, New York, NY; and Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA (A.B.G.).

Background: Utilization of extracorporeal membrane oxygenation (ECMO) is expanding despite limited outcome data defining appropriate use.

Methods And Results: To quantify determinants of early and 1-year survival after ECMO in adult patients, we conducted a retrospective cohort analysis of 1286 patients aged ≥18 years who underwent ECMO in New York State from 2003 to 2014. Median follow-up time was 4. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003179DOI Listing
December 2016
14 Reads

Characteristics and Outcomes of Patients With Myocarditis Listed for Heart Transplantation.

Circ Heart Fail 2016 12;9(12)

From the Advanced Heart Failure and Transplant Center, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, OH.

Background: Myocarditis can cause dilated cardiomyopathy resulting in end-stage heart failure requiring advanced therapies. There is little contemporary information on the clinical progression, need for mechanical circulatory support, and outcomes of orthotopic heart transplantation of these patients.

Methods And Results: We queried the UNOS database (United Network for Organ Sharing) for all adults listed for orthotopic heart transplantation (2000-2015) with a listed diagnosis of myocarditis. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003259DOI Listing
December 2016
12 Reads

Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?

Circ Heart Fail 2016 09;9(9)

From the Department of Cardiology (M.S., T.S.B., S.W., T.F., N.M., A.L., G.S., V.A.) and Department of Cardiac Surgery (M.-T.D.), University of Leipzig, Heart Center, Germany; Department of Circulation and Medical Imaging, Faculty of Medicine, K.G. Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology, Trondheim, Norway (N.R., U.W.); Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan (T.H.); Department of Prevention, Rehabilitation and Sports Medicine, Else Kröner-Fresenius-Zentrum, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany (M.H.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany (M.H.).

Background: A greater understanding of the different underlying mechanisms between patients with heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction is urgently needed to better direct future treatment. However, although skeletal muscle impairments, potentially mediated by inflammatory cytokines, are common in both HFrEF and HFpEF, the underlying cellular and molecular alterations that exist between groups are yet to be systematically evaluated. The present study, therefore, used established animal models to compare whether alterations in skeletal muscle (limb and respiratory) were different between HFrEF and HFpEF, while further characterizing inflammatory cytokines. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003027DOI Listing
September 2016
26 Reads

Deflation Timing Influences Intra-Aortic Balloon Pump-Mediated Carotid Blood Flow Reversal: A Case Report.

Circ Heart Fail 2016 09;9(9)

From the Massachusetts General Hospital and the Harvard Medical School, Boston (R.C.S.); and Houston Methodist DeBakey Heart & Vascular Center, TX (A.B., J.D.E., A.G., B.H.T., Z.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003474DOI Listing
September 2016
4 Reads

Fluid Volume Overload and Congestion in Heart Failure: Time to Reconsider Pathophysiology and How Volume Is Assessed.

Authors:
Wayne L Miller

Circ Heart Fail 2016 08;9(8):e002922

From the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.

Volume regulation, assessment, and management remain basic issues in patients with heart failure. The discussion presented here is directed at opening a reassessment of the pathophysiology of congestion in congestive heart failure and the methods by which we determine volume overload status. Peer-reviewed historical and contemporary literatures are reviewed. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002922DOI Listing
August 2016
59 Reads

Zooming in on the Microvasculature in Heart Failure With Preserved Ejection Fraction.

Circ Heart Fail 2016 07;9(7)

From the MedStar Cardiovascular Research Network, Washington, DC (S.F.M., D.T.M.); and Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN (M.M.R.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070465PMC
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003272DOI Listing
July 2016
6 Reads

Reduced Myocardial Flow in Heart Failure Patients With Preserved Ejection Fraction.

Circ Heart Fail 2016 07;9(7)

From the Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada.

Background: There remains limited insight into the pathophysiology and therapeutic advances directed at improving prognosis for patients with heart failure with preserved ejection fraction (HFpEF). Recent studies have suggested a role for coronary microvascular dysfunction in HFpEF. Rb-82 cardiac positron emission tomography imaging is a noninvasive, quantitative approach to measuring myocardial flow reserve (MFR), a surrogate marker for coronary vascular health. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002562DOI Listing
July 2016
21 Reads

Oxygen Therapy in Patients With Acute Heart Failure: Friend or Foe?

JACC Heart Fail 2016 10 8;4(10):783-790. Epub 2016 Jun 8.

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Supplemental oxygen, a therapy that has been used for more than a century, is recommended in all practice guidelines in the management of hypoxemic (peripheral oxygen saturation <90% to 94% or partial arterial oxygen pressure <60 mm Hg) patients with acute heart failure, but its use in normoxemic patients is controversial. Several pre-clinical and early clinical studies have shown the detrimental effects of oxygen therapy and subsequent hyperoxia in patients with normal oxygen saturation levels. These effects are suggested to be gauged by the increased production of reactive oxygen species and the related oxidative stress and by the reductions in coronary blood flow and myocardial oxygen consumption resulting from hyperoxia-induced vasoconstriction in the cerebral, coronary, and systemic vasculature. Read More

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http://dx.doi.org/10.1016/j.jchf.2016.03.026DOI Listing
October 2016
6 Reads

Right Ventricular Contractile Reserve and Pulmonary Circulation Uncoupling During Exercise Challenge in Heart Failure: Pathophysiology and Clinical Phenotypes.

JACC Heart Fail 2016 08 11;4(8):625-35. Epub 2016 May 11.

Heart Failure Unit, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.

Objectives: Right ventricular (RV) exercise contractile reserve (RVECR), its phenotypes, and its functional correlates are among the unresolved issues with regard to the role of the right ventricle in heart failure (HF) syndrome, and understanding these issues constitutes the objective of this study.

Background: Although the role of the right ventricle in HF syndrome might be fundamental, the pathophysiology of the failing right ventricle has not been extensively investigated.

Methods: Ninety-seven patients with HF (mean age 64 years, 70% men, mean left ventricular ejection fraction 33 ± 10%) underwent maximal exercise stress echocardiographic and cardiopulmonary exercise testing. Read More

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http://dx.doi.org/10.1016/j.jchf.2016.03.007DOI Listing
August 2016
26 Reads

Operating in the Dark: When Is Surgery Necessary for Left Ventricular Assist Device Hemolysis?

Circ Heart Fail 2016 05;9(5)

From the Division of Cardiology, Tufts Cardiovascular Center, Boston, MA (M.S.K.); and Division of Cardiology, University of North Carolina, Chapel Hill (J.N.K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003141DOI Listing
May 2016
7 Reads

Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial.

Circ Heart Fail 2016 Apr;9(4):e002729

From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.H., S.F.M., B.A.B., M.M.R.); Temple University, Philadelphia, PA (P.R.F.); Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (G.D.L.); Duke Clinical Research Institute, Durham, NC (D.S.G.).

Background: Right ventricular (RV) dysfunction (RVD) is a poor prognostic factor in heart failure with preserved ejection fraction (HFpEF). The physiological perturbations associated with RVD or RV function indexed to load (RV-pulmonary arterial [PA] coupling) in HFpEF have not been defined. HFpEF patients with marked impairment in RV-PA coupling may be uniquely sensitive to sildenafil. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831074PMC
April 2016
34 Reads

Development of a Transplantation Risk Index in Patients With Mechanical Circulatory Support: A Decision Support Tool.

JACC Heart Fail 2016 Apr 10;4(4):277-86. Epub 2016 Feb 10.

Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Objectives: The aim of this study was to develop a risk index specific to patients on mechanical circulatory support that accurately predicts 1-year mortality after orthotopic heart transplantation using the United Network for Organ Sharing database.

Background: Few clinical tools are available to aid in the decision between continuing long-term device support and performing transplantation in patients bridging with mechanical circulatory support.

Methods: Using a prospectively collected, open cohort, 6,036 patients receiving mechanical circulatory support who underwent orthotopic heart transplantation between 2000 and 2013 were evaluated and randomly separated into derivation (80%) and validation (20%) groups. Read More

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http://dx.doi.org/10.1016/j.jchf.2015.11.009DOI Listing
April 2016
11 Reads

Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.

Circ Heart Fail 2016 Jan;9(1):e002424

From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD (T.M.L.).

Background: Diabetic heart disease is associated with tetrahydrobiopterin oxidation and high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin (SEP) is a tetrahydrobiopterin precursor, and L-citrulline (L-Cit) is converted to endothelial nitric oxide synthase substrate, L-arginine. Whether SEP and L-Cit are effective at reducing diabetic heart disease is not known. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714787PMC
January 2016
19 Reads

Circulation: Heart Failure.

Authors:

Circ Heart Fail 2016 Jan;9(1):e000010

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http://dx.doi.org/10.1161/HHF.0000000000000010DOI Listing
January 2016
1 Read

Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.

Circ Heart Fail 2016 Jan 23;9(1):e002314. Epub 2015 Dec 23.

From the Department of Pharmacology, Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans (C.L.O., H.O., S.B., J.B., R.T., D.J.P., D.J.L.); Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (Z.W., W.H.W.T., S.L.H.); and Department of Mathematics, Cleveland State University, OH (Y.W.).

Background: Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis. In animal studies, dietary choline or TMAO significantly accelerates atherosclerotic lesion development in ApoE-deficient mice, and reduction in TMAO levels inhibits atherosclerosis development in the low-density lipoprotein receptor knockout mouse.

Methods And Results: C57BL6/J mice were fed either a control diet, a diet containing choline (1. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943035PMC
January 2016
58 Reads

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction.

JACC Heart Fail 2016 Apr 9;4(4):312-24. Epub 2015 Dec 9.

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands; Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.

Objectives: The present study investigated whether systemic, low-grade inflammation of metabolic risk contributed to diastolic left ventricular (LV) dysfunction and heart failure with preseved ejection fraction (HFpEF) through coronary microvascular endothelial activation, which alters paracrine signalling to cardiomyocytes and predisposes them to hypertrophy and high diastolic stiffness.

Background: Metabolic risk is associated with diastolic LV dysfunction and HFpEF.

Methods: We explored inflammatory endothelial activation and its effects on oxidative stress, nitric oxide (NO) bioavailability, and cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signalling in myocardial biopsies of HFpEF patients and validated our findings by comparing obese Zucker diabetic fatty/Spontaneously hypertensive heart failure F1 hybrid (ZSF1)-HFpEF rats to ZSF1-Control (Ctrl) rats. Read More

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http://dx.doi.org/10.1016/j.jchf.2015.10.007DOI Listing
April 2016
38 Reads

Pro-Atrial Natriuretic Peptide: A Novel Guanylyl Cyclase-A Receptor Activator That Goes Beyond Atrial and B-Type Natriuretic Peptides.

JACC Heart Fail 2015 Sep;3(9):715-23

Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Objectives: The aim of this study was to determine if the atrial natriuretic peptide (ANP) precursor proANP is biologically active compared with ANP and B-type natriuretic peptide (BNP).

Background: ProANP is produced in the atria and processed to ANP and activates the guanylyl cyclase receptor-A (GC-A) and its second messenger, cyclic guanosine monophosphate (cGMP). ProANP is found in the human circulation, but its bioavailability is undefined. Read More

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http://dx.doi.org/10.1016/j.jchf.2015.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568029PMC
September 2015
7 Reads

No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure.

Circ Heart Fail 2015 Nov 2;8(6):1088-93. Epub 2015 Sep 2.

From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine (S.D., O.J.R., M.M., M.R., E.S., H.W., H.A., T.D.K., S.N.) and Department of Physiology, Anatomy, and Genetics (C.J.H., L.E.C., K.C.), Oxford University, Oxford, United Kingdom.

Background: Whether the myocardium in nonischemic heart failure experiences oxygen limitation remains a long-standing controversy. We addressed this question in patients with dilated cardiomyopathy (DCM) using a dual approach. First, we tested the changes in myocardial oxygenation between rest and stress states, using oxygenation-sensitive cardiovascular magnetic resonance. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645953PMC
November 2015
28 Reads

Changing the Carburetor Without Changing the Plugs: The Intersection of Stock Car Racing With Mechanically Assisted Circulation.

Authors:
Joseph G Rogers

JACC Heart Fail 2015 Sep 12;3(9):712-4. Epub 2015 Aug 12.

Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2015.07.001DOI Listing
September 2015
5 Reads

Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.

Circ Heart Fail 2015 Sep 31;8(5):980-7. Epub 2015 Jul 31.

From the Center for Systems Biology, Massachusetts General Hospital, Boston (S.H., B.G.C., A.F., A.A., M.N., I.H., Y.S., Y.-X.Y., Y.I., B.T., R.W., M.N., F.K.S.); Biological Sciences, GlaxoSmithKline, Collegeville, PA (M.B.); Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.); GlaxoSmithKline, King of Prussia, PA (C.M.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.L.).

Background: Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6C(high) and reparative Ly-6C(low) monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 phases, impairs infarct healing, and contributes to left ventricle remodeling and heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a member of the phospholipase A2 family of enzymes, produced predominantly by leukocytes, participates in host defenses and disease. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568849PMC
September 2015
26 Reads

Extracorporeal Membrane Oxygenation as a Bridge to Pediatric Heart Transplantation: Effect on Post-Listing and Post-Transplantation Outcomes.

Circ Heart Fail 2015 Sep 23;8(5):960-9. Epub 2015 Jul 23.

From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.I.D.); Children's Healthcare of Atlanta, GA (W.T.M.); University of Alabama at Birmingham (M.T., D.C.N., J.K.K., E.P.); Stanford University, Palo Alto, CA (C.A.); and Vanderbilt University School of Medicine, Nashville, TN (S.A.W.).

Background: Current organ allocation algorithms direct hearts to the sickest recipients to mitigate death while waiting. This may result in lower post-transplant (Tx) survival for high-risk candidates mandating close examination to determine the appropriateness of different technologies as a bridge to Tx.

Methods And Results: We analyzed all patients (<18 years old) from the Pediatric Heart Transplant Study (PHTS) database listed for heart Tx (1993-2013) to determine the effect of extracorporeal membrane oxygenation (ECMO) support at the time of listing and the time of Tx on waitlist mortality and post-Tx outcomes. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.114
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001553DOI Listing
September 2015
10 Reads

Forum for Early Career Clinical Investigation: New Section for Circulation: Heart Failure.

Circ Heart Fail 2015 Jul;8(4):689-90

Editors, Circulation: Heart Failure.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002445DOI Listing
July 2015
5 Reads

Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis.

Circ Heart Fail 2015 Sep 1;8(5):970-9. Epub 2015 Jul 1.

From the Department of Physiology (D.F., A.T., M.S., X.W., Z.K.), Division of Cardiology, Department of Medicine (W.W., R.B., G.Y.O.), Cardiovascular Research Center (D.F., A.T., M.S., X.W., Z.K., W.W., R.B.), Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

Background: A disintegrin and metalloproteinase 17 (ADAM17) is a membrane-bound enzyme that mediates shedding of many membrane-bound molecules, thereby regulating multiple cellular responses. We investigated the role of cardiomyocyte ADAM17 in myocardial infarction (MI).

Methods And Results: Cardiomyocyte-specific ADAM17 knockdown mice (ADAM17(flox/flox)/α-MHC-Cre; f/f/Cre) and parallel controls (ADAM17(flox/flox); f/f) were subjected to MI by ligation of the left anterior descending artery. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002029DOI Listing
September 2015
55 Reads

Prognostic Significance and Determinants of the 6-Min Walk Test in Patients With Heart Failure and Preserved Ejection Fraction.

JACC Heart Fail 2015 Jun;3(6):459-466

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria. Electronic address:

Objectives: This study sought to define the prognostic significance and clinical determinants of the 6-min walk distance (6-MWD) in affected patients.

Background: Symptoms of exertional fatigue and dyspnea, as well as a reduced exercise tolerance, are cardinal features of pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF). Mechanisms limiting exercise capacity in this specific entity remain incompletely understood. Read More

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http://heartfailure.onlinejacc.org/data/Journals/JCHF/934093
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http://linkinghub.elsevier.com/retrieve/pii/S221317791500153
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http://dx.doi.org/10.1016/j.jchf.2015.01.010DOI Listing
June 2015
16 Reads

Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction.

Circ Heart Fail 2015 May 9;8(3):542-50. Epub 2015 Apr 9.

From the Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, MN (M.J.A., S.-J.H., G.C.K., V.M., T.P.O., K.F., B.A.B.); The Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (M.A.J.); The Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea (S.-J.H.); and Department of Cardiology, Institute of Clinical and Experimental Medicine-IKEM, Prague, Czech Republic (V.M.).

Background: Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction (HFpEF), yet their underlying mechanisms remain poorly understood. We sought to examine RV-pulmonary artery (PA) functional reserve responses and RV-PA coupling at rest and during β-adrenergic stimulation in subjects with earlier stage HFpEF.

Methods And Results: In a prospective trial, subjects with HFpEF (n=39) and controls (n=18) underwent comprehensive invasive and noninvasive hemodynamic assessment using high fidelity micromanometer catheters, echocardiography, and expired gas analysis at rest and during dobutamine infusion. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002114DOI Listing
May 2015
45 Reads

Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.

Circ Heart Fail 2015 May 2;8(3):565-71. Epub 2015 Apr 2.

From the Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (J.O.M.O., S.A., J.D.W.E., R.B., M.M.); Department of Cardiothoracic Surgery, Queen Elizabeth Hospital Birmingham NHS Trust, Birmingham, United Kingdom (M.M., R.S.B.); Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (B.O.F., M.F.); and Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom (M.P.F.).

Background: Nitrite exhibits hypoxia-dependent vasodilator properties, selectively dilating capacitance vessels in healthy subjects. Unlike organic nitrates, it seems not to be subject to the development of tolerance. Currently, therapeutic options for decompensated heart failure (HF) are limited. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.114
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435579PMC
May 2015
26 Reads
13 Citations
5.891 Impact Factor

Survival and neurocognitive outcomes after cardiac extracorporeal life support in children less than 5 years of age: a ten-year cohort.

Circ Heart Fail 2015 Mar 9;8(2):312-21. Epub 2015 Jan 9.

From the Department of Pediatrics (L.M.R., G.G.G., A.R.J., C.M.T.R., L.L.), Department of Public Health Sciences (I.A.D.), and Department of Surgery (I.M.R., D.B.R.), University of Alberta, Edmonton, Alberta, Canada; Pediatric Rehabilitation Outcomes Evaluation and Research Unit, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada (C.M.T.R., G.Y.A.); and Pediatric Critical Care Unit, Stollery Children's Hospital, Edmonton, Alberta, Canada (D.G.).

Background: Survival after pediatric cardiac extracorporeal life support (ECLS) is guarded, and neurological morbidity varies widely. Our objective is to report our 10-year experience with cardiac ECLS, including survival and kindergarten entry neurocognitive outcomes; to identify predictors of mortality or adverse neurocognitive outcomes; and to compare 2 eras, before and after 2005.

Methods And Results: From 2000 to 2009, 98 children had venoarterial cardiac ECLS. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001503DOI Listing
March 2015
15 Reads

Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction.

Circ Heart Fail 2015 Mar 30;8(2):278-85. Epub 2014 Dec 30.

From the Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Porto, Portugal (M.S.); Pulmonary and Critical Care Medicine (J.T., A.B.W., D.M.S.) and Division of Cardiovascular Medicine (A.R.O., A.M.S.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Cardiology, Boston Children's Hospital, MA (A.R.O.).

Background: The mechanism of functional limitation in heart failure with preserved ejection fraction remains controversial. We examined the contributions of central cardiac and peripheral mechanisms and hypothesized that the pulmonary vascular response to exercise is an important determinant of aerobic capacity among patients with exertional pulmonary venous hypertension (ePVH).

Methods And Results: We compared 31 ePVH patients (peak VO2<80% of predicted and peak pulmonary arterial wedge pressure≥20 mm Hg) with 31 age- and sex-matched controls (peak VO2>80% predicted) who underwent invasive cardiopulmonary exercise testing for unexplained exertional intolerance. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936392PMC
March 2015
13 Reads

Cerebral hypoperfusion is exaggerated with an upright posture in heart failure: impact of depressed cardiac output.

JACC Heart Fail 2015 Feb 31;3(2):168-75. Epub 2014 Oct 31.

Schlegel-University of Waterloo Research Institute for Aging, Faculty of Applied Health Sciences, Waterloo, Ontario, Canada. Electronic address:

Objectives: The purpose of this study was to examine cerebral blood flow (CBF) supine and during upright sitting in HF patients and control subjects to test the hypothesis that patients with HF will have a greater reduction in CBF from supine to seated compared with the control group.

Background: Reduced CBF has been reported in patients with heart failure (HF). However, previous work has only examined CBF while supine, although an upright posture common to daily living may lead to further reductions. Read More

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http://dx.doi.org/10.1016/j.jchf.2014.07.017DOI Listing
February 2015
9 Reads

Patients with heart failure with reduced ejection fraction have exaggerated reductions in cerebral blood flow during upright posture.

JACC Heart Fail 2015 Feb 31;3(2):176-9. Epub 2014 Oct 31.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas; Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22131779140044
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http://dx.doi.org/10.1016/j.jchf.2014.10.006DOI Listing
February 2015
8 Reads

Effect of macitentan on hospitalizations: results from the SERAPHIN trial.

JACC Heart Fail 2015 Jan 11;3(1):1-8. Epub 2014 Nov 11.

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University Hospital, Bologna, Italy.

Objectives: This study sought to evaluate the effect of macitentan on hospitalization of patients with symptomatic pulmonary arterial hypertension (PAH).

Background: PAH is a progressive, life-threatening disease often requiring hospitalization.

Methods: In the multicenter, double-blind, randomized, event-driven, phase III SERAPHIN (Study with an Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome) trial, patients with symptomatic PAH were randomized (1:1:1) to receive placebo or 3 mg or 10 mg of macitentan. Read More

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http://dx.doi.org/10.1016/j.jchf.2014.07.013DOI Listing
January 2015
37 Reads

Characterization of pulmonary hypertension in heart failure using the diastolic pressure gradient: limitations of a solitary measurement.

JACC Heart Fail 2015 Jan 11;3(1):17-21. Epub 2014 Nov 11.

Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2014.09.002DOI Listing
January 2015
6 Reads

Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure.

Circ Heart Fail 2015 Jan 22;8(1):89-97. Epub 2014 Oct 22.

From the Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN.

Background: We have reported that pro-B-type natriuretic peptide (BNP)-1-108 circulates and is processed to mature BNP1-32 in human blood. Building on these findings, we sought to determine whether proBNP1-108 processed forms in normal circulation are biologically active and stimulate cGMP, and whether proBNP1-108 processing and activity are altered in human heart failure (HF) compared with normal. Because BNP1-32 is deficient whereas proBNP1-108 is abundant in HF, we hypothesize that proBNP1-108 processing and degradation are impaired in HF patients ex vivo. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303547PMC
January 2015
9 Reads

Clinical outcomes after continuous-flow left ventricular assist device: a systematic review.

Circ Heart Fail 2014 Nov 7;7(6):1003-13. Epub 2014 Oct 7.

From the Division of Cardiology (C.K.M., A.V.A., L.A.A.), Adult and Child Center for Health Outcomes Research and Delivery Science (K.H.M., J.S.T.), and Division of General Internal Medicine (D.D.M.), University of Colorado School of Medicine, Aurora; Brown University, School of Public Health, Providence, RI (K.H.M.); and Colorado Cardiovascular Outcomes Research Consortium, Denver (C.K.M., D.D.M., L.A.A.).

Background: Conveying the complex trade-offs of continuous-flow left ventricular assist devices is challenging and made more difficult by absence of an evidence summary for the full range of possible outcomes. We aimed to summarize the current evidence on outcomes of continuous-flow left ventricular assist devices.

Methods And Results: PubMed and Cochrane Library were searched from January 2007 to December 2013, supplemented with manual review. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.114
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241134PMC
November 2014
11 Reads

Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study.

Circ Heart Fail 2014 Nov 6;7(6):994-1002. Epub 2014 Oct 6.

From the University of Groningen, University Medical Center Groningen, The Netherlands (A.A.V., S.M., R.H.J.A.S., G.J.N.); Novartis Pharma AG, Basel, Switzerland (M.D., A.J., D.L.); Institute of Cardiology, Warsaw, Poland (J.S.); University of Maryland, Baltimore (S.S.G.); and Novartis Pharmaceuticals, East Hanover, NJ (Y.Z.).

Background: Serelaxin is a promising therapy for acute heart failure. The renal hemodynamic effects of serelaxin in patients with chronic heart failure are unknown.

Methods And Results: In this double-blind, randomized, placebo-controlled, multicenter study, patients with New York Heart Association Class II to III chronic heart failure, left ventricular ejection fraction ≤45%, and estimated glomerular filtration rate (GFR) 30 to 89 mL/min per 1. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001536DOI Listing
November 2014
26 Reads

Pulmonary hypertension is related to peripheral endothelial dysfunction in heart failure with preserved ejection fraction.

Circ Heart Fail 2014 Sep 21;7(5):791-8. Epub 2014 Jul 21.

From the Heart Failure and Heart Transplantation Program, Cardiology Department, Hospital Clinic (M.F., E.S., M.C., M.A.C., F.P.-V.), and Pulmonary Medicine Department, Hospital Clinic (I.B., J.A.B.), Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS) (I.B., M.B., J.A.B., F.P.-V.); Cardiac Imaging Section, Cardiology Department, Hospital Clinic (B.V.), Barcelona, Spain; and Biomedical Research Networking Centers on Respiratory Diseases (CIBERES) (I.B., J.A.B.), Madrid, Spain.

Background: Pulmonary hypertension (PH) and collagen metabolism abnormalities are prevalent in patients with heart failure with preserved ejection fraction (HFpEF). Peripheral endothelial dysfunction (PED) has been described in HF and in pulmonary arterial hypertension. Our aim is to determine whether PH is associated with PED and impaired collagen metabolism in patients with HFpEF. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000942DOI Listing
September 2014
14 Reads

Coronary microvascular dysfunction is related to abnormalities in myocardial structure and function in cardiac amyloidosis.

JACC Heart Fail 2014 Aug 9;2(4):358-67. Epub 2014 Jul 9.

Cardiovascular Division and Cardiac Amyloidosis Program, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: The purpose of this study was to test the hypothesis that coronary microvascular function is impaired in subjects with cardiac amyloidosis.

Background: Effort angina is common in subjects with cardiac amyloidosis, even in the absence of epicardial coronary artery disease (CAD).

Methods: Thirty-one subjects were prospectively enrolled in this study, including 21 subjects with definite cardiac amyloidosis without epicardial CAD and 10 subjects with hypertensive left ventricular hypertrophy (LVH). Read More

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http://dx.doi.org/10.1016/j.jchf.2014.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127145PMC
August 2014
25 Reads