413,887 results match your criteria Circulation: Cardiovascular Genetics [Journal]


Safe delayed procedure of nipple reconstruction in poorly circulated nipple.

Breast J 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Nipple-areolar complex reconstruction represents the final step in breast reconstruction. However, there is no gold standard nipple reconstruction technique that addresses the issue of blood circulation in the flap, which is the most basic complication. Nipple reconstruction was performed in 21 patients. Read More

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December 2018

Is Early Compression Therapy after Perforator Flap Safe and Reliable?

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background:  Due to the concern of circulation compromise, many surgeons hesitate to dangle or challenge the flap in the early postoperative phase. In our experience, early compression may have advantages such as collapse of dead space, evacuation of hematoma, reduction of edema, and stabilization of flap when ambulating. In this study, the effect of early compression of flaps with regard to flap physiology and outcome is evaluated. Read More

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December 2018

Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Department of Internal Medicine, Spaarne Gasthuis, Haarlem, The Netherlands.

Background: Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients.

Methods: Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Read More

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December 2018

The Retrotransverse foramen of the atlas is not a modern anatomic variation.

World Neurosurg 2018 Dec 14. Epub 2018 Dec 14.

Department of Human Anatomy and Physiology, Faculty of Health Sciences, University of Johannesburg, Auckland Park, 2006, South Africa.

Background: The retrotransverse foramen (RTF) is a nonmetric variant of the atlas vertebra that consists of an abnormal accessory foramen located on the posterior root of the transverse process and it extends from the posterior root of the transverse process to the root of the posterior arch. Its presence has been related to regional variations of the venous circulation. It is currently unknown whether the RTF is a modern or an ancient anatomic variation. Read More

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December 2018
1 Read

One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

Background: Limited data exist regarding neurobehavioral outcomes of children treated with open-chest cardiopulmonary resuscitation (CPR). Our objective was to describe neurobehavioral outcomes one year post-arrest among children who received open-chest CPR during in-hospital cardiac arrest; and explore factors associated with one-year survival and survival with good neurobehavioral outcome.

Methods: The study is a secondary analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital Trial. Read More

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December 2018

Broad-spectrum monoclonal antibodies against chikungunya virus structural proteins: Promising candidates for antibody-based rapid diagnostic test development.

PLoS One 2018 17;13(12):e0208851. Epub 2018 Dec 17.

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

In response to the aggressive global spread of the mosquito-borne chikungunya virus (CHIKV), an accurate and accessible diagnostic tool is of high importance. CHIKV, an arthritogenic alphavirus, comprises three genotypes: East/Central/South African (ECSA), West African (WA), and Asian. A previous rapid immunochromatographic (IC) test detecting CHIKV E1 protein showed promising performance for detection of the ECSA genotype. Read More

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December 2018

Widespread circulation of West Nile virus, but not Zika virus in southern Iran.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007022. Epub 2018 Dec 17.

Department of Clinical Virology, Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.

West Nile virus (WNV) and Zika virus (ZIKV) are mosquito-borne viral infections. Over the past few decades, WNV has been associated with several outbreaks involving high numbers of neuroinvasive diseases among humans. The recent re-emergence of ZIKV has been associated with congenital malformation and also with Guillain-Barre syndrome in adults. Read More

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December 2018
1 Read

Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006975. Epub 2018 Dec 17.

Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, United States of America.

Background: Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined. Read More

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December 2018

Preparation and in vitro / in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles.

Pharm Dev Technol 2018 Dec 17:1-30. Epub 2018 Dec 17.

a Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering , Jiangsu University , Zhenjiang 212013 , People's Republic of China.

6-Gingerol, an active herbal ingredient of ginger, has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was to enhance the oral bioavailability and brain distribution of 6-Gingerol via polymeric micelles. A polymeric micelles drug delivery system of 6-Gingerol consisting of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Poly (ethylene glycol)-poly (ε-caprolactone) (PEG-PCL) was prepared via solvent injection method. Read More

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December 2018

Ischemic Lesions in Acute and Subacute Perimesencephalic Subarachnoid Hemorrhage.

AJR Am J Roentgenol 2018 Dec 17:1-7. Epub 2018 Dec 17.

5 Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

Objective: Perimesencephalic hemorrhage (PMH) is a subtype of nonaneurysmal subarachnoid hemorrhage (SAH). In patients with aneurysmal SAH, the occurrence of acute ischemic lesions is associated with severity and poor outcome. We investigated the frequency of ischemic lesions on DWI in patients with PMH and compared it with the frequency of ischemic lesions in patients with aneurysmal SAH. Read More

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December 2018

Increased perfusion in dynamic gadolinium-enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease.

J Magn Reson Imaging 2018 Dec 16. Epub 2018 Dec 16.

Department of Hand Surgery, Lund University, Malmö, Sweden.

Background: Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast-enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones. Read More

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December 2018

Meningeal carcinomatosis presenting with leukoencephalopathy-like imaging findings.

eNeurologicalSci 2019 Mar 19;14:21-23. Epub 2018 Nov 19.

Department of Neurology, University of Tsukuba, 1-1-1 Tenodai, Tsukuba-city, Japan.

Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles. Read More

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Cerebral fat embolism syndrome in sickle cell disease without evidence of shunt.

eNeurologicalSci 2019 Mar 22;14:19-20. Epub 2018 Nov 22.

Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA.

Fat embolism syndrome (FES) is a known complication of sickle cell disease (SCD) that occurs secondary to vaso-occlusive crises, bone marrow infarction, and the subsequent release of fat globules into the venous circulation. Although neurologic involvement is common, the pathophysiology of cerebral fat emboli remains controversial. While fat microemboli can enter the arterial circulation through right-to-left shunts, the systemic release of free fatty acids may also cause indirect endothelial damage and disruption of the blood-brain-barrier. Read More

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March 2019
1 Read

Secular decrease of wind power potential in India associated with warming in the Indian Ocean.

Sci Adv 2018 Dec 5;4(12):eaat5256. Epub 2018 Dec 5.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

The Indian government has set an ambitious target for future renewable power generation, including 60 GW of cumulative wind power capacity by 2022. However, the benefits of these substantial investments are vulnerable to the changing climate. On the basis of hourly wind data from an assimilated meteorology reanalysis dataset covering the 1980-2016 period, we show that wind power potential may have declined secularly over this interval, particularly in western India. Read More

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December 2018

Skin as an immune organ and clinical applications of skin-based immunotherapy.

World Allergy Organ J 2018 7;11(1):38. Epub 2018 Dec 7.

5Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo Mexico.

Background: The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food allergy as well as other allergic diseases.

Findings: The skin is a multifunctional organ with unique immunologic properties, making it a favorable administration route for allergen-specific immunotherapy. Read More

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December 2018

A Biomimetic Gold Nanocages-Based Nanoplatform for Efficient Tumor Ablation and Reduced Inflammation.

Theranostics 2018 24;8(19):5362-5378. Epub 2018 Oct 24.

National Engineering Research Center for Nanomedicine, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Gold nanocages (AuNCs), with high photothermal conversion efficiency and unique hollow interiors, have become a promising nanoplatform for synergistic phototheraml therapy (PTT)-chemotherapy. However, the insufficient tumor targeting, in vivo premature drug leakage and low drug loading efficiency responsible for the spatial-temporal un-synchronization of PTT-chemotherapy, as well as inflammatory response might compromise the anticancer treatment of AuNCs-based drug delivery systems. Cancer cell membrane (CCM)-coated AuNCs were developed to load anticancer drug doxorubicin (DOX@CAuNCs) by transmembrane ammonium sulfate gradient method. Read More

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October 2018

Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA.

Theranostics 2018 22;8(19):5276-5288. Epub 2018 Oct 22.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.

Muscle atrophy occurs during chronic diseases, resulting in diminished quality of life and compromised treatment outcomes. There is a high demand for therapeutics that increase muscle mass while abrogating the need for special dietary and exercise requirements. Therefore, we developed an efficient nanomedicine approach capable of increasing muscle mass. Read More

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October 2018

Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment.

Int J Nanomedicine 2018 29;13:8063-8074. Epub 2018 Nov 29.

Department of Bioengineering, Northeastern University, Boston, MA, USA,

Background: PARP inhibitors, such as Olaparib, have advanced the treatment of ovarian cancer by providing patients with an effective and molecularly-targeted maintenance therapy. However, all orally-administered drugs, including Olaparib, must undergo first-pass metabolism. In contrast, a nanoparticle delivery system has the advantage of administering Olaparib directly into the peritoneal cavity for local treatment. Read More

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November 2018
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Vitamin B12 Added as a Fortificant to Flour Retains High Bioavailability when Baked in Bread.

Nucl Instrum Methods Phys Res B 2019 Jan 18;438:136-140. Epub 2018 Jun 18.

USDA, ARS Western Human Nutrition Research Center, Davis, California.

Vitamin B12 deficiency and depletion are common world-wide, particularly in populations that consume low amounts of animal source foods. WHO and the Food Fortification Initiative recommend that wheat flour be fortified with vitamin B12 in regions where intake of B12 is low. The purpose of this pilot study in five participants was to determine if fortification of flour with B12 produced a bread product with intact B12 still present and to determine if healthy elderly absorb sufficient B12 from bread fortified in this manner. Read More

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January 2019

Tissue iron is negatively correlated with TERC or TERT mRNA expression: a heterochronic parabiosis study in mice.

Aging (Albany NY) 2018 Dec 16. Epub 2018 Dec 16.

National Clinical Research Center for Aging and Medicine, Huashan Hostital, Laboratory of Neuropharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PRC.

To test the hypothesis that iron accumulation in tissues with age is a key harmful factor for the development of aging, we established heterochronic parabiosis-pairings and investigated changes in serum iron, the expression of major iron transport proteins and iron contents, as well as telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), and telomere length in the liver, kidney and heart of Y-O(O) (old pairing with young), Y-O(Y) (young pairing with old), O-O (pairings between two old) and Y-Y (pairings between two young) mice. We demonstrated that the reduced serum iron, increased iron and reduced expression of TERT and TERC in the tissues of aged mice are reversible by exposure to a younger mouse's circulation. All of these measurements in young mice are reversible by exposure to an older mouse's circulation. Read More

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December 2018

Cognition in breast cancer survivors: A pilot study of interval and continuous exercise.

J Sci Med Sport 2018 Dec 6. Epub 2018 Dec 6.

UC Research Institute for Sport and Exercise, University of Canberra, Australia; Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Australia.

Objectives: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.

Design: Pilot randomised-controlled trial.

Methods: Seventeen female cancer survivors (mean: 62. Read More

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December 2018

[Biology of metastases and molecular mechanisms of their formation].

Bull Cancer 2018 Dec 13. Epub 2018 Dec 13.

Institut Curie, département de biologie des tumeurs, service de génétique, 26, rue d'Ulm, 75248 Paris, France. Electronic address:

Metastasis in cancer patients is often associated with a poor prognosis. However, we still have limited knowledge of the underlying molecular mechanisms, due to the great complexity of the biological processes involved in the formation of metastases. During tumor progression, the metastatic cells acquire genetic and epigenetic modifications allowing them to adapt to the various environments they will encounter (in the circulation and the host microenvironment) and to resist to the antitumor therapeutic agents. Read More

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December 2018

Wearing compression socks during exercise aids subsequent performance.

J Sci Med Sport 2019 Jan 19;22(1):123-127. Epub 2018 Jun 19.

Physiology, Australian Institute of Sport, Australia; Sport Performance Optimisation Research Team (SPORT), University of Tasmania, Australia.

Objectives: To assess the effect of wearing compression socks on immediate and subsequent 5km running time trials, with particular attention to the influences on physiological, perceptual and performance-based parameters.

Design: Counter-balanced cross-over experiment.

Methods: Twelve male runners (mean±SD 5km run time 19:29±1:18min:s) each completed two experimental sessions. Read More

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January 2019

Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade.

Cytokine 2018 Dec 7;112:21-26. Epub 2018 Jul 7.

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck 23538, Germany. Electronic address:

Polymorphonuclear Neutrophils (PMNs) are metabolically highly active phagocytes, present in abundant numbers in the circulation. These active cells take the onus of clearing invading pathogens by crowding at inflammatory sites in huge numbers. Though PMNs are extremely short living and die upon spontaneous apoptosis, extended lifespan has been observed among those cells arrive at the inflammation sites or tackle intracellular infections or face any microbial challenges. Read More

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December 2018

Characterization of Flow Efficiency, Pulsatility, and Respiratory Variability in Different Types of Fontan Circuits Using Quantitative Parameters.

Yonsei Med J 2019 Jan;60(1):56-64

Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Details on the hemodynamic differences among Fontan operations remain unclear according to respiratory and cardiac cycles. This study was undertaken to investigate hemodynamic characteristics in different types of Fontan circulation by quantification of blood flow with the combined influence of cardiac and respiratory cycles.

Materials And Methods: Thirty-five patients [10 atriopulmonary connections (APC), 13 lateral tunnels (LT), and 12 extracardiac conduits (ECC)] were evaluated, and parameters were measured in the superior vena cava, inferior vena cava (IVC), hepatic vein (HV), baffles, conduits, and left and right pulmonary artery. Read More

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January 2019

Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More

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December 2018

Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D.

J Steroid Biochem Mol Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Calcitroic acid, the excretory form of vitamin D, is the terminal product of a 5-step pathway catalyzed by CYP24A1, commencing with C24-hydroxylation of 1,25-dihydroxyvitamin D (1,25-(OH)D). Catabolism of 25-hydroxyvitamin D (25-OH-D) proceeds via analogous steps culminating in calcioic acid; however this C23-truncated acid has not been reported in the circulation. It has recently been shown that 24,25-dihydroxyvitamin D (24,25-(OH)D) is an important factor in optimal bone fracture healing acting via an effector molecule FAM57B2 to produce lactosylceramide. Read More

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December 2018

Hypothesis II: The majority of VLDL-apoB48 remnants in postprandial plasma are derived from the liver, not from the intestine.

Clin Chim Acta 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan.

We have long thought that remnant lipoproteins (RLP) in the postprandial plasma contain CM remnants (exogenous remnants; RLP-apoB48) and VLDL remnants (endogenous remnants; RLP-apoB100) of different origin, i.e. produced in the intestine and liver, respectively. Read More

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December 2018

The impact of hydroelectric dams on mercury dynamics in South America: A review.

Chemosphere 2018 Dec 6;219:546-556. Epub 2018 Dec 6.

Programa de Pós-Graduação Em Ecologia e Recursos Naturais, Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia, Universidade Estadual Do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000 - Parque Califórnia, CEP: 28013-602, Campos Dos Goytacazes, Rio de Janeiro, Brazil.

The increase in global demand for electric energy is reflected in plans to construct numerous hydroelectric dams in South America that can cause chronic ecological impacts if not built and managed correctly. One of the main impacts generated by hydropower dams is the accumulation of Hg chemical species in their reservoir compartments and the downstream transport of these contaminants. Hg circulation in these environments has been studied for 27 years and this review brings a synthesis of the dynamics that are now well established, so that future studies can focus on gaps and inconsistent results in the literature. Read More

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December 2018
6 Reads

Detection of norovirus epidemic genotypes in raw sewage using next generation sequencing.

Environ Int 2018 Dec 12;123:282-291. Epub 2018 Dec 12.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.

Noroviruses are a leading cause of epidemic and pandemic acute gastroenteritis (AGE) worldwide, and contaminated food and water are important routes for its transmission. Raw sewage has been used for viral surveillance to monitor the emergence of new norovirus strains with the potential to cause epidemics. In this study, we investigated norovirus occurrence and norovirus RNA levels in 156 samples collected from May 2013 to May 2014, across three different stages (52 samples each) of a wastewater treatment plant (WWTP) in Rio de Janeiro, Brazil. Read More

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December 2018
3 Reads

Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions.

Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:

Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More

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November 2018
1 Read

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More

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December 2018
1 Read

Technical Aspects of the Use of the Radial Artery in Coronary Artery Bypass Surgery.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, United States.

Background: The radial artery (RA) has been used for coronary artery bypass surgery for more than 25 years. The recent confirmation of the clinical benefits associated with the use of the artery is likely to drive a new interest toward this conduit in the next few years METHODS: A group of surgeons with extensive experience in the systematic use of the RA summarize here the key technical aspects of the use of the conduit for coronary bypass operations.

Results: Preoperative evaluation of the ulnar collateral circulation and attention to the characteristics of the target vessel are key for the successful use of the radial artery. Read More

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December 2018
1 Read

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany.

Aim: Pharmacologic administration of insulin as nasal spray in humans has demonstrated a modulation of endogenous glucose production via the brain when systemic insulin levels are high. Results are conflicting under fasting insulin concentrations. To evaluate effects of brain insulin on endogenous glucose production in fasting humans with focus on hepatic glucose release, we performed a randomized, placebo controlled, blinded, cross-over experiment. Read More

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December 2018
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Probable reverse zoonosis of influenza A(H1N1)pdm 09 in a striped skunk (Mephitis mephitis).

Zoonoses Public Health 2018 Dec 14. Epub 2018 Dec 14.

Wildlife and Habitat Branch, BC Ministry of Forests, Lands, Natural Resource Operations and Rural Development, Nanaimo, British Columbia, Canada.

Striped skunks (skunks) are susceptible to respiratory infection by influenza A viruses (IAV). As they are common synanthropes, maintenance of IAV in skunks could provide a source of infection for humans. We previously studied the nasal turbinates, lungs and faeces of 50 free-ranging skunks for the presence of IAV and identified two individuals with influenza A(H1N1)pdm09 infection during the 2009/2010 and 2013/2014 flu seasons. Read More

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December 2018

Existence and features of the myodural bridge in Gallus domesticus: indication of its important physiological function.

Anat Sci Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.

The myodural bridge (MDB) is a dense connective tissue that connects muscles with the cervical spinal dura mater via the posterior atlanto-occipital and atlato-axial interspaces. To date, the physiological function of the MDB has not been fully elucidated. Recent studies have identified the presence of the MDB in mammals, but very little information is available on the existence of the MDB in avifauna. Read More

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December 2018

Spatiotemporal dynamics and risk factors of rotavirus A circulation in backyard pig farms in a Philippine setting.

Trop Anim Health Prod 2018 Dec 14. Epub 2018 Dec 14.

School of Management, University of the Philippines Mindanao, Mintal, 8022, Davao City, Philippines.

Rotavirus A is one of the leading etiological agents of porcine gastroenteritis, a condition which results to stunted growth among piglets. Moreover, there is increasing evidence for zoonosis of rotavirus A (RVA), which is also the principal cause of diarrhea in children. In the absence of rigorous animal health monitoring in Philippine backyard farms, there is therefore a strong need for RVA surveillance. Read More

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December 2018
1 Read

Imaging in neurointerventional stroke treatment: review of the recent trials and what your neurointerventionalist wants to know from emergency radiologists.

Emerg Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology and Biomedical Imaging, University of California San Francisco School of Medicine, 550 16th. Street, San Francisco, CA, 94158, USA.

Stroke is one of the leading causes of death and disability worldwide. Standard treatment for stroke is intravenous (IV) injection of tissue plasminogen activator (t-PA) rapidly after symptom onset. However, there are limitations of IV t-PA treatment, such as a short time window for administration and risk for hemorrhage. Read More

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December 2018

Arc of Bühler: the surgical significance of a rare anatomical variation.

Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy and Surgical Anatomy, School of Medicine, National and Kapodistrian University of Athens, Tetrapoleos 18, 75 Mikras Asias Str, 11527, Athens, Greece.

Purpose: The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications. Read More

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December 2018

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Acetaminophen (APAP) is one of the most commonly used analgesics worldwide, and overdoses are associated with lactic acidosis, hepatocyte toxicity, and acute liver failure due to oxidative stress and mitochondrial dysfunction. Hepatoma cell lines typically lack the CYP450 activity to generate the reactive metabolite of APAP observed in vivo, but are still subject to APAP cytotoxicity. In this study, we employed metabolic profiling and isotope labelling approaches to investigate the metabolic impact of acute exposure to cytotoxic doses of APAP on the widely used HepG2 cell model. Read More

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December 2018
1 Read

Along-shelf connectivity and circumpolar gene flow in Antarctic silverfish (Pleuragramma antarctica).

Sci Rep 2018 Dec 14;8(1):17856. Epub 2018 Dec 14.

Department of Biology, University of Padua, Via G. Colombo 3, Padua, 35121, Italy.

The Antarctic silverfish (Pleuragramma antarctica) is a critically important forage species with a circumpolar distribution and is unique among other notothenioid species for its wholly pelagic life cycle. Previous studies have provided mixed evidence of population structure over regional and circumpolar scales. The aim of the present study was to test the recent population hypothesis for Antarctic silverfish, which emphasizes the interplay between life history and hydrography in shaping connectivity. Read More

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December 2018

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos.

Nat Commun 2018 Dec 14;9(1):5314. Epub 2018 Dec 14.

Department of Medicine, University of California-San Diego, La Jolla, CA, 92093, USA.

Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how fates of individual vessels are determined. Read More

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December 2018
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Injury factors alter miRNAs profiles of exosomes derived from islets and circulation.

Aging (Albany NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Islets damage is a major abnormality underling diabetes. Recent studies suggested the value of exosomes in diagnosis. This study aimed to investigate the impact of injury factors on the miRNA profiles of islet exosomes and determine whether circulating exosomal miRNAs is suitable as biomarkers of islets damage. Read More

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December 2018

Molecular identification of enteroviruses from cattle and goat feces and environment in Thailand.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

The identification and characterization of the viruses of the genus in healthy and infected livestock, including cattle and goats, have been increasing. (EV-E) and (EV-F) are commonly found in cattle, whereas (EV-G) is found in goats. In this study, molecular and phylogenetic analyses were performed to determine the prevalence of EVs in cattle and goat feces from the Kanchanaburi Province, Thailand. Read More

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December 2018

Pipeline shield with single antiplatelet therapy in aneurysmal subarachnoid haemorrhage: multicentre experience.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, New South Wales, Australia.

Background: The Pipeline Embolisation Device with Shield technology (PED-Shield) is suggested to have reduced thrombogenicity. This reduced thrombogenicity may make it possible to use safely in the acute treatment of aneurysmal subarachnoid haemorrhage (aSAH) on single antiplatelet therapy (SAPT).

Objective: To evaluate the safety and efficacy of the off-label use of PED-Shield with SAPT for the acute treatment of aSAH. Read More

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December 2018

Insect heart rhythmicity is modulated by evolutionarily conserved neuropeptides and neurotransmitters.

Curr Opin Insect Sci 2018 Oct 11;29:41-48. Epub 2018 Jun 11.

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA. Electronic address:

Insects utilize an open circulatory system to transport nutrients, waste, hormones and immune factors throughout the hemocoel. The primary organ that drives hemolymph circulation is the dorsal vessel, which is a muscular tube that traverses the length of the body and is divided into an aorta in the head and thorax, and a heart in the abdomen. The dorsal vessel is myogenic, but its rhythmicity is modulated by neuropeptides and neurotransmitters. Read More

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October 2018

Reassortment of bluetongue virus vaccine serotypes in cattle.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e7. Epub 2018 Dec 5.

Department of Veterinary Tropical Diseases, University of Pretoria.

Bluetongue is primarily a disease of sheep in South Africa, while cattle and goats are mostly subclinically infected. The viraemia of bluetongue virus in cattle lasts much longer than in sheep and the role of cattle in the epidemiology of bluetongue in South Africa is poorly understood. Bluetongue virus has a segmented double-stranded ribonucleic acid genome and reassortment of genomes is a common feature. Read More

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December 2018

Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects.

Biomed Pharmacother 2019 Jan 5;109:823-830. Epub 2018 Nov 5.

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, China. Electronic address:

Objective: The discovery of cell free fetal microRNAs (miRNAs) in maternal circulation has opened up novel probabilities for non-invasive prenatal diagnosis. This study aims to investigate circulating miRNAs as potential biomarkers in the serum of pregnant women with congenital heart defect (CHD) fetuses.

Method: A total of 110 pregnant women including 50 CHD cases and 60 healthy controls were included in this study. Read More

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January 2019

A simple and rapid-acting approach for the reduction of C-reactive protein.

Biomed Pharmacother 2019 Jan 29;109:2305-2308. Epub 2018 Nov 29.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

C-reactive protein (CRP) is an acute-phase protein which can bind to and aggregate oxidized low-density lipoprotein (ox-LDL) particles, thereby enhancing the uptake of oxLDL by macrophages. This finally leads to the formation of foam cells that are a typical characteristic of atherosclerotic plaques. Serum CRP has been shown to bind to phospholipids such as phophatidylcholine (PC), phosphatidylglycerol (PG) and phosphatidylserine (PS). Read More

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January 2019

Microneedles: A smart approach and increasing potential for transdermal drug delivery system.

Biomed Pharmacother 2019 Jan 9;109:1249-1258. Epub 2018 Nov 9.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia.

The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which serves as a barrier for the molecules and thus only a few molecules are able to reach the site of action. A new form of delivery system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various problems associated with the conventional formulations. Read More

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January 2019
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