413,764 results match your criteria Circulation: Arrhythmia and Electrophysiology [Journal]


Evaluation of Genotoxicity of Nanoparticles in Mouse Models.

Methods Mol Biol 2019 ;1894:301-312

Cancer Research Center, University at Albany, State University of New York, Rensselaer, NY, USA.

Owing to new and unique properties, engineered nanoparticles (NPs) likely pose different risks than their constituent chemicals and these risks need to be understood. In particular, it is important to assess genotoxicity, since genotoxicity is a precursor to carcinogenicity. Here we describe a battery of tests for the assessment of genotoxicity of NPs in vivo in mice. Read More

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January 2019
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The availability of drug by liposomal drug delivery : Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate.

Invest New Drugs 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Pharmacy, Division of Laboratory Medicine & Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands.

Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the underlying pharmacokinetics of the targeted drug delivery by liposomes, individual encapsulated and non-encapsulated drug concentrations in blood, tumor, liver, spleen and kidneys were quantified after i.v. Read More

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December 2018

Glacial changes in tropical climate amplified by the Indian Ocean.

Sci Adv 2018 Dec 12;4(12):eaat9658. Epub 2018 Dec 12.

National Center for Atmospheric Research, Climate and Global Dynamics Laboratory, 1850 Table Mesa Drive, Boulder, CO 80305, USA.

The mechanisms driving glacial-interglacial changes in the climate of the Indo-Pacific warm pool are poorly understood. Here, we address this question by combining paleoclimate proxies with model simulations of the Last Glacial Maximum climate. We find evidence of two mechanisms explaining key patterns of ocean cooling and rainfall change interpreted from proxy data. Read More

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December 2018

Post-traumatic pseudoaneurysms of the left gastric artery: A case report.

Trauma Case Rep 2019 Feb 5;19:1-6. Epub 2018 Dec 5.

Department of General Surgery, Division of Trauma Surgery, Eulji University Hostpital, Daejeon, Republic of Korea.

Post-traumatic pseudoaneurysm of the gastric artery is very rare. Prompt diagnosis and management are necessary because mortality is high due to massive intra-abdominal hemorrhage. A 79-year-old man complained of abdominal pain after slipping down 2 days prior to admission. Read More

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February 2019

Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Cureus 2018 Oct 9;10(10):e3434. Epub 2018 Oct 9.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. Read More

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October 2018

A Lack of Reserve: Recognizing the Large Impact of Small Vessels in the Heart.

Circulation 2018 Jul 23;138(4):424-428. Epub 2018 Jul 23.

Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts.

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Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700, Fribourg, Switzerland.

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental evidence that ER breast cancer cells that survived high-dose Doxorubicin and Methotrexate based chemotherapies elicit a state of immunological dormancy. Read More

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December 2018

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Cardiology, Erasme University Hospital, Brussels, Belgium.

The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. Read More

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December 2018

Pulmonary hypertension due to left heart disease.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

University of California, San Francisco, CA, USA.

Pulmonary hypertension (PH) is frequent in left heart disease (LHD), as a consequence of the underlying condition. Significant advances have occurred over the past 5 years since the 5th World Symposium on Pulmonary Hypertension in 2013, leading to a better understanding of PH-LHD, challenges and gaps in evidence. PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH. Read More

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December 2018

Diagnosis of pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.

A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed. Read More

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December 2018

Chronic thromboembolic pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Royal Papworth Hospital, Cambridge, UK.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of pulmonary embolism and a major cause of chronic PH leading to right heart failure and death. Lung ventilation/perfusion scintigraphy is the screening test of choice; a normal scan rules out CTEPH. In the case of an abnormal perfusion scan, a high-quality pulmonary angiogram is necessary to confirm and define the pulmonary vascular involvement and prior to making a treatment decision. Read More

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December 2018
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Haemodynamic definitions and updated clinical classification of pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Pulmonary Circulation Unit, Pulmonary Division, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.

Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent data from normal subjects has shown that normal mPAP was 14.0±3. Read More

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December 2018

Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.

Surg Obes Relat Dis 2018 Nov 2. Epub 2018 Nov 2.

Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois; Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois. Electronic address:

Background: Roux-en-Y gastric bypass surgery (RYGB) increases the rate of alcohol absorption so that peak blood alcohol concentration is 2-fold higher after surgery compared with concentrations reached after consuming the same amount presurgery. Because high doses of alcohol can lead to hypoglycemia, patients may be at increased risk of developing hypoglycemia after alcohol ingestion.

Objectives: We conducted 2 studies to test the hypothesis that the consumption of approximately 2 standard drinks of alcohol would decrease glycemia more after RYGB than before surgery. Read More

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November 2018
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Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature.

Biomedicines 2018 Dec 11;6(4). Epub 2018 Dec 11.

Fondazione Novara Sviluppo, 28100 Novara, Italy.

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Read More

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December 2018
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Metabolic Signature of Dietary Iron Overload in a Mouse Model.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Department of Internal Medicine II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid excessive reactive oxygen species formation. Iron overload impairs mitochondrial fitness; however, little is known about the associated metabolic changes. Read More

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December 2018

Use of Three Air Samplers for the Detection of PRRSV-1 under Experimental and Field Conditions.

Animals (Basel) 2018 Dec 7;8(12). Epub 2018 Dec 7.

Department for Farm Animals and Veterinary Public Health, University Clinic for Swine, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Airborne transmission of porcine reproductive and respiratory syndrome virus (PRRSV) has been known for a long time. Most experiments were performed using PRRSV-2 strains and fairly little information is available on the airborne spread of PRRSV-1. The aim of this study was to assess three different air samplers for their ability to detect PRRSV-1 under experimental and field conditions. Read More

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December 2018

Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes.

Medicine (Baltimore) 2018 Dec;97(49):e12959

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University.

Background: The blood-brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRTl) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (AIS) patients. Read More

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December 2018

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon.

Eur Surg Res 2018 Dec 13;59(5-6):371-379. Epub 2018 Dec 13.

The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More

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December 2018

Atmospheric transport of I and Cs from Fukushima by the East Asian northeast monsoon.

J Environ Radioact 2018 Dec 10;197:74-80. Epub 2018 Dec 10.

Vietnam Atomic Energy Institute, 59 Ly Thuong Kiet, Hanoi, Viet Nam.

The Lagrangian particle dispersion model FLEXPART was used to simulate atmospheric dispersion of radionuclides from the Fukushima nuclear power plant (FNPP) towards the Tropical Western Pacific (TWP) and Southeast Asia (SEA). The simulation model distinguished between hemispherical transport via the jet stream and regional transport within the marine boundary layer by the East Asian northeast monsoon. This regional transport was driven by anticyclonic circulation over southern Japan and the western Pacific resulting from a recurrent eastward extension of the Siberian High to the Pacific Ocean. Read More

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December 2018

Endovascular therapy for acute vertebrobasilar occlusion underlying atherosclerosis: A single institution experience.

Clin Neurol Neurosurg 2018 Nov 29;176:78-82. Epub 2018 Nov 29.

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China. Electronic address:

Objective: To compare the safety and efficacy of endovascular therapy in acute ischemic stroke (AIS) caused by large artery occlusion (LAO) in the posterior circulation with or without intracranial atherosclerosis (ICAS).

Patient And Methods: The study enrolled patients who underwent endovascular therapy for AIS caused by posterior circulation LAO. Inclusion criteria for endovascular therapy of vertebrobasilar occlusion were as follows: (1) CTA or MRA confirmed acute vertebrobasilar occlusion; (2) baseline NIHSS score ≥2; (3) premorbid mRS score ≤2; (4) onset or last known well time to puncture within 24 h; (5) pc-ASPECTS ≥6. Read More

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November 2018

Plasma Concentrations of Myeloid-Derived Growth Factor in Healthy Individuals and Patients with Acute Myocardial Infarction as Assessed by Multiple Reaction Monitoring-Mass Spectrometry.

Anal Chem 2018 Dec 13. Epub 2018 Dec 13.

Myeloid-derived growth factor (MYDGF in humans, Mydgf in mice) is a secreted protein with previously unknown biological functions. In a recent study, Mydgf was shown to mediate cardiac repair after acute myocardial infarction (MI) in mice. Lack of a sensitive assay to measure MYDGF in the circulation has hampered its further investigation. Read More

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December 2018

Nitric Oxide in Life and Death of Neutrophils.

Curr Med Chem 2018 Dec 12. Epub 2018 Dec 12.

Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow 119234`. Russian Federation.

Background: Nitric oxide (NO) is a key signalling molecule that has an important role in inflammation. It can be secreted by endothelial cells, neutrophils, and other cells, and once in circulation, NO plays important roles in regulating various neutrophil cellular activities and fate.

Objective: To describe neutrophil cellular responses influenced by NO and its concomitant compound peroxynitrite and signalling mechanisms for neutrophil apoptosis. Read More

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December 2018

Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles.

J Cardiovasc Transl Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Science, University of Oslo, Postbox 1103, Blindern, 0317, Oslo, Norway.

During heart surgery with cardiopulmonary bypass (CPB), the release of mitochondrial (mtDNA) and nuclear DNA (nDNA) and their association to extracellular vesicles were investigated. In patients undergoing elective coronary artery bypass grafting (CABG, n = 12), blood was sampled before, during, and after surgery from peripheral artery, pulmonary artery, and the coronary sinus. Plasma was separated in three fractions: microvesicles, exosomes, and supernatant. Read More

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December 2018

Characteristics and relative factors of headache caused by cervicocerebral artery dissection.

J Neurol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe east Road, Zhengzhou, 450052, Henan, China.

Objective: To analyze the characteristics and relative factors of headache and neck pain due to cervicocerebral artery dissection (CAD).

Methods: A total of 146 consecutive patients with CAD in Zhengzhou, China (2010-2017) were observed and registered prospectively. There were 60 (60/146) cases who complained of headache and neck pain, and we analyzed the characteristics of pain according to their clinical features. Read More

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December 2018

Are we aiming to miss in translational autoimmunity treatments?

F1000Res 2018 6;7:1754. Epub 2018 Nov 6.

Webb-Waring Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA.

Autoimmunity treatments, fruitfully pioneered in mouse models, can be disappointing or result in immunosuppression and opportunistic infections in translational trials. Many possible reasons exist, but one major, overlooked reason may be the treatment timing in relation to circadian oscillations of the immune system. Mice and humans both have immunological circadian clocks and experience the same circulatory oscillations of immune cells with regards to their sleep/wake phases, but have opposite sleep/wake phases with regard to the daylight cycle. Read More

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November 2018

Polymer-drug conjugate therapeutics: advances, insights and prospects.

Nat Rev Drug Discov 2018 Dec 12. Epub 2018 Dec 12.

Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, MA, USA.

Polymer-drug conjugates have long been a mainstay of the drug delivery field, with several conjugates successfully translated into clinical practice. The conjugation of therapeutic agents to polymeric carriers, such as polyethylene glycol, offers several advantages, including improved drug solubilization, prolonged circulation, reduced immunogenicity, controlled release and enhanced safety. In this Review, we discuss the rational design, physicochemical characteristics and recent advances in the development of different classes of polymer-drug conjugates, including polymer-protein and polymer-small-molecule drug conjugates, dendrimers, polymer nanoparticles and multifunctional systems. Read More

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December 2018

Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicity and Species-Specificities of Hepadnaviruses in Primates, Rodents and Bats.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Univ Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, F-69622, Villeurbanne, France

Human hepatitis B virus (HBV) is a global health problem, affecting more than 250 million people worldwide. HBV-like viruses, named orthohepadnaviruses, also naturally infect non-human primates, rodents and bats, but their pathogenicity and evolutionary history are unclear. Here, we determined the evolutionary history of HBV receptors, NTCP and GPC5, over millions of years of primate, rodent and bat evolution. Read More

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December 2018

Media representation of the antimicrobial resistance (AMR) crisis: An Australian perspective.

Infect Dis Health 2018 Oct 20. Epub 2018 Oct 20.

Deakin University, Alfred Deakin Research Institute for Citizenship and Globalisation, Australia.

Background: Antimicrobial resistance and the rise of 'super bugs' has become a major threat to public health worldwide, with authorities warning of an 'apocalyptic future' unless addressed as a matter of urgency. Mass circulation media has traditionally taken an active role in informing the public of important public health issues and the measures needed to address these. The key objective of the larger project informing this article was to describe Australian media representations of the AMR crisis and its role in informing the public about the AMR crisis. Read More

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October 2018

[Research progress of gut microbiota and microbiota-targeted therapy in critical ill patients].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1099-1102

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China. Corresponding author: Pan Suyue, Email:

Objective: In physiological conditions, a diverse microbiota might enhance host defense. However, the gut microbiota of critically ill patients is characterized by lower diversity, lower abundances of key commensal genera, and overgrowth by one bacterial generation, a state known as dysbiosis. Increasing evidences indicate that microbiota-derived components can reach the systemic circulation from the gut and modulate immune homeostasis. Read More

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November 2018

[Effects between chest-compression-only cardiopulmonary resuscitation and standard cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: a Meta-analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1017-1023

Department of Emergency, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China (Liao XL, Tang H, Wang YZ, Wang M, Zhou MH); Department of Biomedical Engineering and Imaging, Army Medical University, Chongqing 400000, China (Chen BH). Corresponding author: Zhou Manhong, Email:

Objective: To comprehensively evaluate and compare the resuscitation efficacy of chest-compression-only cardiopulmonary resuscitation (CCPR) and standard cardiopulmonary resuscitation (SCPR) for patients with out-of-hospital cardiac arrest (OHCA).

Methods: Databases such as PubMed, Embase, Ovid, Cochrane Library, Wanfang, CNKI, VIP, CBM were searched from the date of their foundation to March 2nd 2018, and the studies on the difference of effects between CCPR and SCPR for patients with OHCA were retrieved. The outcomes included the return of spontaneous circulation (ROSC) rate, survival to hospital discharge, neurological function completion rate. Read More

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November 2018

Mobilizing political support proved critical to a successful switch from tOPV to bOPV in Kano, Nigeria 2016.

BMC Public Health 2018 Dec 13;18(Suppl 4):1302. Epub 2018 Dec 13.

Africa Field Epidemiology Network, Hospital Road, Kano, Kano State, Nigeria.

Background: Kano is one of the high-risk states for polio transmission in Northern Nigeria. The state reported more cases of wild polioviruses (WPVs) than any other state in the country. The Nigeria Demographic and Health Survey of 2013 indicated that OPV3 coverage in the routine immunization (RI) programmewas 57. Read More

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December 2018

Effect of ultrafiltration during hemodialysis on hepatic and total-body water: an observational study.

BMC Nephrol 2018 Dec 12;19(1):356. Epub 2018 Dec 12.

The Lilibeth Caberto Kidney Clinical Research Unit, Victoria Hospital, Western University, A2-344, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.

Background: The hepatic circulation is involved in adaptive systemic responses to circulatory stress. However, it is vulnerable to both chronic hypervolemia and cardiac dysfunction. The influence of hemodialysis (HD) and ultrafiltration (UF) upon liver water content has been understudied. Read More

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December 2018

Prevalence, Morphology, Embryogenesis, and Diagnostic Utility of Umbilical Cord Vitelline Vascular Remnants.

Authors:
James R Wright

Pediatr Dev Pathol 2018 Dec 12:1093526618811734. Epub 2018 Dec 12.

1 Department of Pathology & Laboratory Medicine, University of Calgary/Calgary Laboratory Services, Alberta Children's Hospital, Calgary, Alberta, Canada.

The objective of this study is to better understand embryonic vitelline vascular remnants in the umbilical cord, to assess their prevalence, to categorize their morphology, and then finally to describe and assess inflammation arising from these structures. During routine placental sign out, the author noted the presence or absence of vitelline vessel remnants for 1 year; when present, he assessed their histologic patterns and noted whether there were neutrophils marginating from the remnants and into the adjacent Wharton's jelly and whether there was any other evidence of amniotic fluid infection in sections of placental disc, membranes, or cord. All cord sections with vitelline vessel remnants were immunostained for CD15 to document any infiltrates, to highlight patterns of infiltration, and to evaluate whether mild cases of umbilical phlebitis were associated with these lesions and were at risk of being missed. Read More

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December 2018

Mycobacterium chimaera in heater-cooler units: new technical approach for treatment, cleaning and disinfection protocol.

Perfusion 2018 Dec 12:267659118814691. Epub 2018 Dec 12.

2 Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Milan, Italy.

Mycobacterium chimaera infections have mainly been associated with the heater-cooler unit (HCU) and, ultimately, linked to contaminated aerosols in the operation room. The contamination status of HCUs seems to be influenced by the maintenance, therefore, according to the manufacturer's recommendations, peracetic acid (Puristeril) was introduced to increase HCU cleaning and disinfection protocol maintenance. Aerosol dispersion from Puristeril during maintenance can cause adverse effects to nearby workers. Read More

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December 2018

ECG Challenge: February 17, 2015.

Authors:

Circulation 2015 Feb;131(7):681

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February 2015

Circulation: Clinical Summaries.

Authors:

Circulation 2015 Feb;131(7):597-598

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February 2015

Effects of Concentric and Eccentric Training on the Stiffness and Blood Circulation of the Patellar Tendon.

Sports Med Int Open 2017 Feb 15;1(2):E43-E49. Epub 2017 Mar 15.

Department of Human and Environmental Well-being, Wako University, Machida, Tokyo, Japan.

The aim of the present study was to investigate the effects of concentric (CON) and eccentric (ECC) training on stiffness and blood circulation of the tendon, and clarify whether relative changes in tendon stiffness are related to those in tendon blood circulation. 17 subjects were assigned to training (n=9) and control (n=8) groups. Training group completed 12 weeks of unilateral training program for knee extensors. Read More

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February 2017

Blood Clearance of Citric Acid-Coated Superparamagnetic Iron Oxide Nanoparticles in Rats - a Pilot Study.

Curr Health Sci J 2015 Oct-Dec;41(4):302-306. Epub 2015 Dec 22.

Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania.

Superparamagnetic iron oxide nanoparticles are primarily utilized for different biomedical applications such as magnetic resonance imaging (MRI), hyperthermia, cancer treatment, targeted delivery of drugs or genes and biosensors. Nanoparticles are interesting due to their unique proprieties together with minor side effects. It is essential to determine the blood clearance of superparamagnetic nanoparticles (SPIONs) for in vivo biomedical applications, to ensure their optimum clinical use. Read More

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December 2015

Molecular characterization of Peste des petits ruminants viruses in the Marmara Region of Turkey.

Transbound Emerg Dis 2018 Dec 7. Epub 2018 Dec 7.

University of Istanbul, Veterinary Faculty, Department of Virology, Avcilar, Istanbul, Turkey.

Recent outbreaks of Peste des petits ruminants (PPR) in the Marmara region of Turkey including the European part of Thrace is important due to its proximity to Europe (Greece and Bulgaria) and the potential threat of spread of PPR into mainland Europe. In order to investigate the circulation of PPRV in the region suspect clinical and necropsy samples were collected from domestic sheep (n=211) in the Marmara region of Turkey between 2011 and 2012. PPR virus (PPRV) genome was detected in 10. Read More

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December 2018
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SIRT3 Deficiency Promotes High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease In Correlation With Impaired Intestinal Permeability Through Gut Microbial Dysbiosis.

Mol Nutr Food Res 2018 Dec 7:e1800612. Epub 2018 Dec 7.

M. Chen, S. Hui, H. Lang, M. Zhou, Y. Zhang, C. Kang, X. Zeng, Q. Zhang, L. Yi, M. Mi, Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.

Scope: Sirtuin 3 (SIRT3) plays a protective role against non-alcoholic fatty liver disease (NAFLD) by improving hepatic mitochondrial dysfunction. Gut microbiota imbalance contributes to the pathogenesis of NAFLD, yet the underlying mechanism linking SIRT3 with gut microbiota in NAFLD progression remains obscure.

Methods And Results: Wild-type 129 mice and SIRT3 knockout (SIRT3KO) mice were under a chow diet or high-fat diet (HFD) treatment for 18-weeks. Read More

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December 2018

Anti-Inflammatory and Antioxidant Properties of Black Mulberry ( L.) in a Model of LPS-Induced Sepsis.

Oxid Med Cell Longev 2018 7;2018:5048031. Epub 2018 Nov 7.

Laboratório de Bioquímica Metabólica (LBM), Departamento de Ciências Biológicas (DECBI), Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.

Sepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Read More

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November 2018

Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.

Front Immunol 2018 20;9:2698. Epub 2018 Nov 20.

Department of Biochemistry, University of Lausanne, Lausanne, Switzerland.

B cell activating factor of the TNF family (BAFF, also known as BLyS), a cytokine that regulates homeostasis of peripheral B cells, is elevated in the circulation of patients with autoimmune diseases such as systemic lupus erythematosus (SLE). BAFF is synthetized as a membrane-bound protein that can be processed to a soluble form after cleavage at a furin consensus sequence, a site that in principle can be recognized by any of the several proteases of the pro-protein convertase family. Belimumab is a human antibody approved for the treatment of SLE, often cited as specific for the soluble form of BAFF. Read More

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November 2018

A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation .

Front Immunol 2018 22;9:2684. Epub 2018 Nov 22.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Read More

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November 2018
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Functional Outcome and Safety of Intracranial Thrombectomy After Emergent Extracranial Stenting in Acute Ischemic Stroke Due to Tandem Occlusions.

Front Neurol 2018 20;9:940. Epub 2018 Nov 20.

Klinik für Neuroradiologie, Klinikum Stuttgart, Stuttgart, Germany.

Various endovascular approaches to treat acute ischemic stroke caused by extra- intracranial tandem occlusions (TO) exist: percutaneous transluminal angioplasty with or without emergent extracranial carotid stenting (ECS) due to high-grade stenosis preceded or followed by intracranial mechanical and/or aspiration thrombectomy (MT). Which treatment strategy to use is still a matter of debate. From our ongoing prospective stroke registry we retrospectively analyzed 1,071 patients with anterior circulation stroke getting endovascular treatment within 6 h of symptom onset. Read More

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November 2018

Supine vs. Prone Position With Turn of the Head Does Not Affect Cerebral Perfusion and Oxygenation in Stable Preterm Infants ≤32 Weeks Gestational Age.

Front Physiol 2018 22;9:1664. Epub 2018 Nov 22.

Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.

Intraventricular hemorrhage (IVH) is a frequent major damage to the brain of premature babies ≤32 weeks gestational age, and its incidence (20-25%) has not significantly changed lately. Because of the intrinsic fragility of germinal matrix blood vessels, IVH occurs following disruption of subependymal mono-layer arteries and is generally attributed to ischemia-reperfusion alterations or venous congestion, which may be caused by turn of the head. Therefore, supine position with the head in a midline position is considered a standard position for preterm infants during their first days of life. Read More

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November 2018

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.

Circulation 2018 Nov 15;138(22):2499-2512. Epub 2018 Aug 15.

Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.

Background: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial.

Methods: 228 circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5,359 individuals (2,659 on treatment) in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial at 6-months post-randomization. Read More

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November 2018

In Aptamers They Trust: The Caveats of the SOMAscan Biomarker Discovery Platform from SomaLogic.

Circulation 2018 Nov 26;138(22):2482-2485. Epub 2018 Nov 26.

King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, United Kingdom.

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November 2018