3,264 results match your criteria Circle of Willis


Blood Pressure and the Brain: How Low Can You Go?

Authors:
John C Drummond

Anesth Analg 2019 Apr;128(4):759-771

From the Department of Anesthesiology, the University of California San Diego, La Jolla, California; and Anesthesia Service, VA Medical Center, San Diego, California.

There are occasionally intraoperative circumstances in which reduction of mean arterial pressure (MAP) to levels well below those that occur in nonanesthetized adults is necessary or unavoidable. In these situations, clinicians are inevitably concerned about the limits of the tolerance of the brain for hypotension. Reference to the phenomenon of cerebral blood flow autoregulation is frequently made in discussions of safe MAP limits. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004034DOI Listing

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion.

J Vis Exp 2019 Mar 1(145). Epub 2019 Mar 1.

Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University;

In this study, a middle cerebral artery (MCA) occlusion mouse model is employed to study cerebral ischemia-reperfusion. A reproducible and reliable mouse model is useful for investigating the pathophysiology of cerebral ischemia-reperfusion and determining potential therapeutic strategies for patients with stroke. Variations in the anatomy of the circle of Willis of C57BL/6 mice affects their infarct volume after cerebral-ischemia-induced injury. Read More

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http://dx.doi.org/10.3791/59078DOI Listing

Microsurgical Angioarchitectonics of Deep Brain Structures and Deep Arterial Anastomoses.

World Neurosurg 2019 Mar 14. Epub 2019 Mar 14.

Research Fellow at National Medical Research Center "Burdenko Neurosurgical Institute", Moscow, Russia.

Surgeries for deep and eloquent cerebral lesions require a detailed knowledge of normal brain anatomy and accurate planning. Important parts of brain anatomy are the cerebral blood supply and collateral circulation system. In addition to well-known cortical and basal (circle of Willis) anastomoses, there is also a deep interarterial anastomotic circle that is not described in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.213DOI Listing

Commentary: Functional assessment of circle of Willis-interesting observation or critical consideration?

J Thorac Cardiovasc Surg 2019 Feb 6. Epub 2019 Feb 6.

University Clinic of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.105DOI Listing
February 2019

Iulius Casserius, a relatively underestimated anatomist: his contributions to brain's anatomy.

Childs Nerv Syst 2019 Mar 8. Epub 2019 Mar 8.

Department of Anatomy, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Iulius Casserius is to be remembered for his excellent contributions in Anatomy and especially in Neuroanatomy. His persistent and meticulous scientific anatomical work resulted in the first record of the arterial circle of the brain 37 years before the comprehensive description by Thomas Willis. Casserius' great interest in the human brain led him to the discovery of plenty anatomical structures before their official documentation. Read More

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http://dx.doi.org/10.1007/s00381-019-04104-4DOI Listing

Automatic image processing pipeline for tracking longitudinal vessel changes in magnetic resonance angiography.

J Magn Reson Imaging 2019 Mar 7. Epub 2019 Mar 7.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA (Work Origin).

Background: Cerebral vessel diameter changes objectively and automatically derived from longitudinal magnetic resonance angiography (MRA) facilitate quantification of vessel changes and further modeling.

Purpose: To characterize longitudinal changes in intracranial vessel diameter using time-of-flight (TOF) MRA.

Study Type: Retrospective longitudinal study. Read More

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http://dx.doi.org/10.1002/jmri.26699DOI Listing

Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

Authors:
B P Abbott R Abbott T D Abbott F Acernese K Ackley C Adams T Adams P Addesso R X Adhikari V B Adya C Affeldt B Agarwal M Agathos K Agatsuma N Aggarwal O D Aguiar L Aiello A Ain P Ajith B Allen G Allen A Allocca M A Aloy P A Altin A Amato A Ananyeva S B Anderson W G Anderson S V Angelova S Antier S Appert K Arai M C Araya J S Areeda M Arène N Arnaud K G Arun S Ascenzi G Ashton M Ast S M Aston P Astone D V Atallah F Aubin P Aufmuth C Aulbert K AultONeal C Austin A Avila-Alvarez S Babak P Bacon F Badaracco M K M Bader S Bae P T Baker F Baldaccini G Ballardin S W Ballmer S Banagiri J C Barayoga S E Barclay B C Barish D Barker K Barkett S Barnum F Barone B Barr L Barsotti M Barsuglia D Barta J Bartlett I Bartos R Bassiri A Basti J C Batch M Bawaj J C Bayley M Bazzan B Bécsy C Beer M Bejger I Belahcene A S Bell D Beniwal M Bensch B K Berger G Bergmann S Bernuzzi J J Bero C P L Berry D Bersanetti A Bertolini J Betzwieser R Bhandare I A Bilenko S A Bilgili G Billingsley C R Billman J Birch R Birney O Birnholtz S Biscans S Biscoveanu A Bisht M Bitossi M A Bizouard J K Blackburn J Blackman C D Blair D G Blair R M Blair S Bloemen O Bock N Bode M Boer Y Boetzel G Bogaert A Bohe F Bondu E Bonilla R Bonnand P Booker B A Boom C D Booth R Bork V Boschi S Bose K Bossie V Bossilkov J Bosveld Y Bouffanais A Bozzi C Bradaschia P R Brady A Bramley M Branchesi J E Brau T Briant F Brighenti A Brillet M Brinkmann V Brisson P Brockill A F Brooks D D Brown S Brunett C C Buchanan A Buikema T Bulik H J Bulten A Buonanno D Buskulic C Buy R L Byer M Cabero L Cadonati G Cagnoli C Cahillane J Calderón Bustillo T A Callister E Calloni J B Camp M Canepa P Canizares K C Cannon H Cao J Cao C D Capano E Capocasa F Carbognani S Caride M F Carney J Casanueva Diaz C Casentini S Caudill M Cavaglià F Cavalier R Cavalieri G Cella C B Cepeda P Cerdá-Durán G Cerretani E Cesarini O Chaibi S J Chamberlin M Chan S Chao P Charlton E Chase E Chassande-Mottin D Chatterjee Katerina Chatziioannou B D Cheeseboro H Y Chen X Chen Y Chen H-P Cheng H Y Chia A Chincarini A Chiummo T Chmiel H S Cho M Cho J H Chow N Christensen Q Chu A J K Chua S Chua K W Chung S Chung G Ciani A A Ciobanu R Ciolfi F Cipriano C E Cirelli A Cirone F Clara J A Clark P Clearwater F Cleva C Cocchieri E Coccia P-F Cohadon D Cohen A Colla C G Collette C Collins L R Cominsky M Constancio L Conti S J Cooper P Corban T R Corbitt I Cordero-Carrión K R Corley N Cornish A Corsi S Cortese C A Costa R Cotesta M W Coughlin S B Coughlin J-P Coulon S T Countryman P Couvares P B Covas E E Cowan D M Coward M J Cowart D C Coyne R Coyne J D E Creighton T D Creighton J Cripe S G Crowder T J Cullen A Cumming L Cunningham E Cuoco T Dal Canton G Dálya S L Danilishin S D'Antonio K Danzmann A Dasgupta C F Da Silva Costa V Dattilo I Dave M Davier D Davis E J Daw B Day D DeBra M Deenadayalan J Degallaix M De Laurentis S Deléglise W Del Pozzo N Demos T Denker T Dent R De Pietri J Derby V Dergachev R De Rosa C De Rossi R DeSalvo O de Varona S Dhurandhar M C Díaz L Di Fiore M Di Giovanni T Di Girolamo A Di Lieto B Ding S Di Pace I Di Palma F Di Renzo A Dmitriev Z Doctor V Dolique F Donovan K L Dooley S Doravari I Dorrington M Dovale Álvarez T P Downes M Drago C Dreissigacker J C Driggers Z Du P Dupej S E Dwyer P J Easter T B Edo M C Edwards A Effler H-B Eggenstein P Ehrens J Eichholz S S Eikenberry M Eisenmann R A Eisenstein R C Essick H Estelles D Estevez Z B Etienne T Etzel M Evans T M Evans V Fafone H Fair S Fairhurst X Fan S Farinon B Farr W M Farr E J Fauchon-Jones M Favata M Fays C Fee H Fehrmann J Feicht M M Fejer F Feng A Fernandez-Galiana I Ferrante E C Ferreira F Ferrini F Fidecaro I Fiori D Fiorucci M Fishbach R P Fisher J M Fishner M Fitz-Axen R Flaminio M Fletcher H Fong J A Font P W F Forsyth S S Forsyth J-D Fournier S Frasca F Frasconi Z Frei A Freise R Frey V Frey P Fritschel V V Frolov P Fulda M Fyffe H A Gabbard B U Gadre S M Gaebel J R Gair L Gammaitoni M R Ganija S G Gaonkar A Garcia C García-Quirós F Garufi B Gateley S Gaudio G Gaur V Gayathri G Gemme E Genin A Gennai D George J George L Gergely V Germain S Ghonge Abhirup Ghosh Archisman Ghosh S Ghosh B Giacomazzo J A Giaime K D Giardina A Giazotto K Gill G Giordano L Glover E Goetz R Goetz B Goncharov G González J M Gonzalez Castro A Gopakumar M L Gorodetsky S E Gossan M Gosselin R Gouaty A Grado C Graef M Granata A Grant S Gras C Gray G Greco A C Green R Green E M Gretarsson P Groot H Grote S Grunewald P Gruning G M Guidi H K Gulati X Guo A Gupta M K Gupta K E Gushwa E K Gustafson R Gustafson O Halim B R Hall E D Hall E Z Hamilton H F Hamilton G Hammond M Haney M M Hanke J Hanks C Hanna M D Hannam O A Hannuksela J Hanson T Hardwick J Harms G M Harry I W Harry M J Hart C-J Haster K Haughian J Healy A Heidmann M C Heintze H Heitmann P Hello G Hemming M Hendry I S Heng J Hennig A W Heptonstall F J Hernandez M Heurs S Hild T Hinderer D Hoak S Hochheim D Hofman N A Holland K Holt D E Holz P Hopkins C Horst J Hough E A Houston E J Howell A Hreibi E A Huerta D Huet B Hughey M Hulko S Husa S H Huttner T Huynh-Dinh A Iess N Indik C Ingram R Inta G Intini H N Isa J-M Isac M Isi B R Iyer K Izumi T Jacqmin K Jani P Jaranowski D S Johnson W W Johnson D I Jones R Jones R J G Jonker L Ju J Junker C V Kalaghatgi V Kalogera B Kamai S Kandhasamy G Kang J B Kanner S J Kapadia S Karki K S Karvinen M Kasprzack M Katolik S Katsanevas E Katsavounidis W Katzman S Kaufer K Kawabe N V Keerthana F Kéfélian D Keitel A J Kemball R Kennedy J S Key F Y Khalili B Khamesra H Khan I Khan S Khan Z Khan E A Khazanov N Kijbunchoo Chunglee Kim J C Kim K Kim W Kim W S Kim Y-M Kim E J King P J King M Kinley-Hanlon R Kirchhoff J S Kissel L Kleybolte S Klimenko T D Knowles P Koch S M Koehlenbeck S Koley V Kondrashov A Kontos M Korobko W Z Korth I Kowalska D B Kozak C Krämer V Kringel B Krishnan A Królak G Kuehn P Kumar R Kumar S Kumar L Kuo A Kutynia S Kwang B D Lackey K H Lai M Landry R N Lang J Lange B Lantz R K Lanza A Lartaux-Vollard P D Lasky M Laxen A Lazzarini C Lazzaro P Leaci S Leavey C H Lee H K Lee H M Lee H W Lee K Lee J Lehmann A Lenon M Leonardi N Leroy N Letendre Y Levin J Li T G F Li X Li S D Linker T B Littenberg J Liu X Liu R K L Lo N A Lockerbie L T London A Longo M Lorenzini V Loriette M Lormand G Losurdo J D Lough G Lovelace H Lück D Lumaca A P Lundgren R Lynch Y Ma R Macas S Macfoy B Machenschalk M MacInnis D M Macleod I Magaña Hernandez F Magaña-Sandoval L Magaña Zertuche R M Magee E Majorana I Maksimovic N Man V Mandic V Mangano G L Mansell M Manske M Mantovani F Marchesoni F Marion S Márka Z Márka C Markakis A S Markosyan A Markowitz E Maros A Marquina F Martelli L Martellini I W Martin R M Martin D V Martynov K Mason E Massera A Masserot T J Massinger M Masso-Reid S Mastrogiovanni A Matas F Matichard L Matone N Mavalvala N Mazumder J J McCann R McCarthy D E McClelland S McCormick L McCuller S C McGuire J McIver D J McManus T McRae S T McWilliams D Meacher G D Meadors M Mehmet J Meidam E Mejuto-Villa A Melatos G Mendell D Mendoza-Gandara R A Mercer L Mereni E L Merilh M Merzougui S Meshkov C Messenger C Messick R Metzdorff P M Meyers H Miao C Michel H Middleton E E Mikhailov L Milano A L Miller A Miller B B Miller J Miller M Millhouse J Mills M C Milovich-Goff O Minazzoli Y Minenkov J Ming C Mishra S Mitra V P Mitrofanov G Mitselmakher R Mittleman D Moffa K Mogushi M Mohan S R P Mohapatra M Montani C J Moore D Moraru G Moreno S Morisaki B Mours C M Mow-Lowry G Mueller A W Muir Arunava Mukherjee D Mukherjee S Mukherjee N Mukund A Mullavey J Munch E A Muñiz M Muratore P G Murray A Nagar K Napier I Nardecchia L Naticchioni R K Nayak J Neilson G Nelemans T J N Nelson M Nery A Neunzert L Nevin J M Newport K Y Ng S Ng P Nguyen T T Nguyen D Nichols A B Nielsen S Nissanke A Nitz F Nocera D Nolting C North L K Nuttall M Obergaulinger J Oberling B D O'Brien G D O'Dea G H Ogin J J Oh S H Oh F Ohme H Ohta M A Okada M Oliver P Oppermann Richard J Oram B O'Reilly R Ormiston L F Ortega R O'Shaughnessy S Ossokine D J Ottaway H Overmier B J Owen A E Pace G Pagano J Page M A Page A Pai S A Pai J R Palamos O Palashov C Palomba A Pal-Singh Howard Pan Huang-Wei Pan B Pang P T H Pang C Pankow F Pannarale B C Pant F Paoletti A Paoli M A Papa A Parida W Parker D Pascucci A Pasqualetti R Passaquieti D Passuello M Patil B Patricelli B L Pearlstone C Pedersen M Pedraza R Pedurand L Pekowsky A Pele S Penn C J Perez A Perreca L M Perri H P Pfeiffer M Phelps K S Phukon O J Piccinni M Pichot F Piergiovanni V Pierro G Pillant L Pinard I M Pinto M Pirello M Pitkin R Poggiani P Popolizio E K Porter L Possenti A Post J Powell J Prasad J W W Pratt G Pratten V Predoi T Prestegard M Principe S Privitera G A Prodi L G Prokhorov O Puncken M Punturo P Puppo M Pürrer H Qi V Quetschke E A Quintero R Quitzow-James D S Rabeling H Radkins P Raffai S Raja C Rajan B Rajbhandari M Rakhmanov K E Ramirez A Ramos-Buades Javed Rana P Rapagnani V Raymond M Razzano J Read T Regimbau L Rei S Reid D H Reitze W Ren F Ricci P M Ricker K Riles M Rizzo N A Robertson R Robie F Robinet T Robson A Rocchi L Rolland J G Rollins V J Roma R Romano C L Romel J H Romie D Rosińska M P Ross S Rowan A Rüdiger P Ruggi G Rutins K Ryan S Sachdev T Sadecki M Sakellariadou L Salconi M Saleem F Salemi A Samajdar L Sammut L M Sampson E J Sanchez L E Sanchez N Sanchis-Gual V Sandberg J R Sanders N Sarin B Sassolas P R Saulson O Sauter R L Savage A Sawadsky P Schale M Scheel J Scheuer P Schmidt R Schnabel R M S Schofield A Schönbeck E Schreiber D Schuette B W Schulte B F Schutz S G Schwalbe J Scott S M Scott E Seidel D Sellers A S Sengupta D Sentenac V Sequino A Sergeev Y Setyawati D A Shaddock T J Shaffer A A Shah M S Shahriar M B Shaner L Shao B Shapiro P Shawhan H Shen D H Shoemaker D M Shoemaker K Siellez X Siemens M Sieniawska D Sigg A D Silva L P Singer A Singh A Singhal A M Sintes B J J Slagmolen T J Slaven-Blair B Smith J R Smith R J E Smith S Somala E J Son B Sorazu F Sorrentino T Souradeep A P Spencer A K Srivastava K Staats M Steinke J Steinlechner S Steinlechner D Steinmeyer B Steltner S P Stevenson D Stocks R Stone D J Stops K A Strain G Stratta S E Strigin A Strunk R Sturani A L Stuver T Z Summerscales L Sun S Sunil J Suresh P J Sutton B L Swinkels M J Szczepańczyk M Tacca S C Tait C Talbot D Talukder D B Tanner M Tápai A Taracchini J D Tasson J A Taylor R Taylor S V Tewari T Theeg F Thies E G Thomas M Thomas P Thomas K A Thorne E Thrane S Tiwari V Tiwari K V Tokmakov K Toland M Tonelli Z Tornasi A Torres-Forné C I Torrie D Töyrä F Travasso G Traylor J Trinastic M C Tringali L Trozzo K W Tsang M Tse R Tso D Tsuna L Tsukada D Tuyenbayev K Ueno D Ugolini A L Urban S A Usman H Vahlbruch G Vajente G Valdes N van Bakel M van Beuzekom J F J van den Brand C Van Den Broeck D C Vander-Hyde L van der Schaaf J V van Heijningen A A van Veggel M Vardaro V Varma S Vass M Vasúth A Vecchio G Vedovato J Veitch P J Veitch K Venkateswara G Venugopalan D Verkindt F Vetrano A Viceré A D Viets S Vinciguerra D J Vine J-Y Vinet S Vitale T Vo H Vocca C Vorvick S P Vyatchanin A R Wade L E Wade M Wade R Walet M Walker L Wallace S Walsh G Wang H Wang J Z Wang W H Wang Y F Wang R L Ward J Warner M Was J Watchi B Weaver L-W Wei M Weinert A J Weinstein R Weiss F Wellmann L Wen E K Wessel P Weßels J Westerweck K Wette J T Whelan B F Whiting C Whittle D Wilken D Williams R D Williams A R Williamson J L Willis B Willke M H Wimmer W Winkler C C Wipf H Wittel G Woan J Woehler J K Wofford W K Wong J Worden J L Wright D S Wu D M Wysocki S Xiao W Yam H Yamamoto C C Yancey L Yang M J Yap M Yazback Hang Yu Haocun Yu M Yvert A Zadrożny M Zanolin T Zelenova J-P Zendri M Zevin J Zhang L Zhang M Zhang T Zhang Y-H Zhang C Zhao M Zhou Z Zhou S J Zhu X J Zhu A B Zimmerman M E Zucker J Zweizig N N Weinberg

Phys Rev Lett 2019 Feb;122(6):061104

Department of Physics, and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Read More

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https://link.aps.org/doi/10.1103/PhysRevLett.122.061104
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http://dx.doi.org/10.1103/PhysRevLett.122.061104DOI Listing
February 2019
2 Reads

A functional assessment of the circle of Willis before aortic arch surgery using transcranial Doppler.

J Thorac Cardiovasc Surg 2019 Jan 11. Epub 2019 Jan 11.

Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands; Department of Cardiothoracic Surgery, Academic Medical Center Amsterdam, Amsterdam, The Netherlands. Electronic address:

Background: Antegrade selective cerebral perfusion (ASCP) with systemic moderate hypothermia is routinely used as brain protection during aortic arch surgery. Whether ASCP should be delivered unilaterally (u-ASCP) or bilaterally (bi-ASCP) remains controversial.

Methods: We routinely studied the functional anatomy of the circle of Willis (CoW in all patients scheduled for arch surgery using transcranial color-coded Doppler over a decade. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.007DOI Listing
January 2019

A 9-Year Longitudinal Study of Basilar Artery Diameter.

J Am Heart Assoc 2019 Mar;8(5):e011154

1 Department of Neurology and Stroke Center Osaka University Graduate School of Medicine Suita, Osaka Japan.

Background Dilatation of the basilar artery ( BA ) has been recognized as a predictor of cardiovascular events ( CVE s). However, it is unclear if the longitudinal change in BA diameter (Δ BA ) is associated with CVE s. Methods and Results In a cohort of Japanese participants with vascular risk factors in an observational study, we evaluated the relationship of Δ BA to CVE s and the time course of the BA diameter. Read More

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http://dx.doi.org/10.1161/JAHA.118.011154DOI Listing
March 2019
2 Reads

Circle of Willis variations in migraine patients with ischemic stroke.

Brain Behav 2019 Mar 16;9(3):e01223. Epub 2019 Feb 16.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.

Materials And Methods: Participants were recruited from the prospective Dutch acute Stroke Study. Read More

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http://dx.doi.org/10.1002/brb3.1223DOI Listing
March 2019
1 Read

Configuration of the circle of Willis and its two parts among Egyptian: a magnetic resonance angiographic study.

Folia Morphol (Warsz) 2019 Feb 14. Epub 2019 Feb 14.

Anatomy Department, Faculty of Medicine, Cairo University, Cairo, Egypt, Egypt.

Background: We hypothesized that the collateral circulation differs in different ethnic groups. So, the aim of our work was to study variations of the circle of Willis (COW) among Egyptian and to compare our findings with the findings of other nationalities.

Material And Methods: One hundred patients were studied using magnetic resonance angiographic (3D-TOF-MRA). Read More

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http://dx.doi.org/10.5603/FM.a2019.0015DOI Listing
February 2019

Simultaneous Measurements of Intracellular Calcium and Membrane Potential in Freshly Isolated and Intact Mouse Cerebral Endothelium.

J Vis Exp 2019 Jan 20(143). Epub 2019 Jan 20.

Department of Basic Sciences, Loma Linda University;

Cerebral arteries and their respective microcirculation deliver oxygen and nutrients to the brain via blood flow regulation. Endothelial cells line the lumen of blood vessels and command changes in vascular diameter as needed to meet the metabolic demand of neurons. Primary endothelial-dependent signaling pathways of hyperpolarization of membrane potential (Vm) and nitric oxide typically operate in parallel to mediate vasodilation and thereby increase blood flow. Read More

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http://dx.doi.org/10.3791/58832DOI Listing
January 2019

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice.

J Vis Exp 2019 Jan 23(143). Epub 2019 Jan 23.

Department of Neuroscience, Psychology and Behaviour, University of Leicester; School of Psychology, University of Nottingham;

The ischemic stroke is a major cause of adult long-term disability and death worldwide. The current treatments available are limited, with only tissue plasminogen activator (tPA) as an approved drug treatment to target ischemic strokes. Current research in the field of ischemic stroke focuses on better understanding the pathophysiology of stroke, to develop and investigate novel pharmaceutical targets. Read More

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http://dx.doi.org/10.3791/58191DOI Listing
January 2019
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Whole-ventricular irradiation for intracranial germ cell tumors: Dosimetric comparison of pencil beam scanned protons, intensity-modulated radiotherapy and volumetric-modulated arc therapy.

Clin Transl Radiat Oncol 2019 Feb 9;15:53-61. Epub 2019 Jan 9.

Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, Villigen, Aargau, Switzerland.

Background: Whole-ventricular radiotherapy (WV-RT) followed by a boost to the tumor bed (WV-RT/TB) is recommended for intracranial germ cell tumors (IGCT). As the critical brain areas are mainly in the target volume vicinity, it is unclear if protons indeed substantially spare neurofunctional organs at risk (NOAR). Therefore, a dosimetric comparison study of WV-RT/TB was conducted to assess whether proton or photon radiotherapy achieves better NOAR sparing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183009
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http://dx.doi.org/10.1016/j.ctro.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357692PMC
February 2019
3 Reads

Human tissue kallikrein in the treatment of acute ischemic stroke.

Ther Adv Neurol Disord 2019 20;12:1756286418821918. Epub 2019 Jan 20.

DiaMedica Therapeutics, Minneapolis, MN, USA.

Acute ischemic stroke (AIS) remains a major cause of death and disability throughout the world. The most severe form of stroke results from large vessel occlusion of the major branches of the Circle of Willis. The treatment strategies currently available in western countries for large vessel occlusion involve rapid restoration of blood flow through removal of the offending blood clot using mechanical or pharmacological means (e. Read More

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http://dx.doi.org/10.1177/1756286418821918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348491PMC
January 2019
1 Read

Spontaneous bilateral internal carotid and vertebral artery dissections with dominant-hemisphere circulation maintained by external carotid artery-ophthalmic artery anastomoses.

Neurosurg Focus 2019 Feb;46(2):E6

3Department of Radiology, and.

Spontaneous cervical artery dissection (sCAD) is a major cause of stroke in young adults. Multiple sCAD is a rarer, more poorly understood presentation of sCAD that has been increasingly attributed to cervical trauma such as spinal manipulation or genetic polymorphisms in extracellular matrix components. The authors present the case of a 49-year-old, otherwise healthy woman, who over the course of 2 weeks developed progressive, hemodynamically significant, bilateral internal carotid artery and vertebral artery dissections. Read More

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http://dx.doi.org/10.3171/2018.11.FOCUS18443DOI Listing
February 2019
2 Reads
2.105 Impact Factor

Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study.

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Departments of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, IL. United States.

Background: Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circulation, such as with CAS, increase compensatory flow demands via the Circle of Willis (COW) and may induce similar stress at the basilar apex.

Objective: We present a series of nine unruptured basilar apex aneurysms (BAA) with CAS and a comparative radiographic analysis to BAA without CAS. Read More

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http://dx.doi.org/10.2174/1567202616666190129150403DOI Listing
January 2019

[Reperfusion therapy in patients with minor or mild ischemic stroke].

Authors:
Junpei Koge

Rinsho Shinkeigaku 2019 Feb 31;59(2):84-92. Epub 2019 Jan 31.

Division of Neurology, Saiseikai Fukuoka General Hospital.

A significant number of patients with minor or mild stroke symptoms on initial presentation subsequently develop neurological deterioration and poor clinical outcomes at hospital discharge. The presence of an underlying large vessel occlusion is a strong predictor of both clinical worsening and poor outcome. Although patients with a low baseline National Institutes of Health Stroke Scale (NIHSS) could have been included in some randomized controlled trials, the benefits of the mechanical thrombectomy for patients with a low NIHSS score are unknown. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001255DOI Listing
February 2019

Magnetic resonance angiography determined variations in the circle of Willis: Analysis of a large series from a single center.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):52-59

Department of Radiology, St. John's Medical College, Bengaluru, Karnataka, India.

Objective: The purpose of this study is to evaluate and describe the prevalence and patterns of arterial variants in the circle of Willis (CW) seen in noncontrast three-dimensional time-of-flight magnetic resonance angiography in a series of patients with cerebral vascular accidents (CVAs).

Materials And Methods: A descriptive study was undertaken in 200 patients who presented for screening for CVA in the Department of Radiodiagnosis and Imaging, St. John's Medical College Hospital, Bengaluru, from September 2014 to September 2016. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_167_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334567PMC
January 2019
1 Read

Revascularization for Cerebral Ischemia, Step-by-Step Demonstration of Bonnet Bypass: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.

The superficial temporal artery (STA) to the middle cerebral artery (MCA) bypass is the most common bypass type for revascularization to treat cerebral ischemia. If the ipsilateral STA is not available for anastomosis, various options for bypass conduits can be exercised. When the entire ipsilateral external carotid and its branches are not available, the contralateral STA may be used as a donor artery through an interposition graft. Read More

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http://dx.doi.org/10.1093/ons/opy400DOI Listing
January 2019
1 Read

Braided stents and their impact in intracranial aneurysm treatment for distal locations: from flow diverters to low profile stents.

Expert Rev Med Devices 2019 Mar 6;16(3):237-251. Epub 2019 Feb 6.

a Department of Neuroradiology and Endovascular Treatment , Jean-Minjoz University Hospital , Besancon , France.

Introduction: Intracranial aneurysms in distal locations are sometimes difficult to treat due to their branching locations and the presence of blister-like or very wide-necked aneurysms. Braided intracranial stents, including flow diverters (FDs) and low-profile braided intracranial stents (LPBSs) may provide additional advantages, due to their flow-diverting properties. Areas covered: The use of FDs in off-label, distal intracranial locations has been increasing with promising outcomes and has given rise to the LPBS, which has less flow-diverting properties, allowing for easier use in distal branching sites through 0. Read More

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http://dx.doi.org/10.1080/17434440.2019.1575725DOI Listing
March 2019
1 Read

Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography.

Transl Stroke Res 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.

A rodent model of embolic middle cerebral artery occlusion is used to mimic cerebral embolism in clinical patients. Thrombolytic therapy is the effective treatment for this ischemic injury. However, it is difficult to detect thrombolysis dynamically in living animals. Read More

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http://dx.doi.org/10.1007/s12975-019-0687-6DOI Listing
January 2019
2 Reads

An In-Vitro Flow Study Using an Artificial Circle of Willis Model for Validation of an Existing One-Dimensional Numerical Model.

Ann Biomed Eng 2019 Apr 23;47(4):1023-1037. Epub 2019 Jan 23.

Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, 45435, USA.

A one-dimensional (1D) numerical model has been previously developed to investigate the hemodynamics of blood flow in the entire human vascular network. In the current work, an experimental study of water-glycerin mixture flow in a 3D-printed silicone model of an anatomically accurate, complete circle of Willis (CoW) was conducted to investigate the flow characteristics in comparison with the simulated results by the 1D numerical model. In the experiment, the transient flow and pressure waveforms were measured at 13 selected segments within the flow network for comparisons. Read More

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http://dx.doi.org/10.1007/s10439-019-02211-6DOI Listing

A Spectacular Endoscopic Anatomy of the Pituitary Gland and the Circle of Willis in a Living Person.

Iran J Med Sci 2019 Jan;44(1):81-82

Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330531PMC
January 2019

Comparative analysis of coil embolization in posterior and anterior communicating artery aneurysms.

J Neurointerv Surg 2019 Jan 17. Epub 2019 Jan 17.

Department of Radiology, Korea Veterans Hospital Medical Center, Seoul, The Republic of Korea.

Background: Recanalization rates after coil embolization are known to be higher in cerebral aneurysms of the posterior (vs anterior) circulation. Although often grouped with anterior lesions, aneurysms of the posterior communicating artery (PcoA) may nevertheless behave differently.

Objective: We performed a comparative analysis to explore differences in recanalization rates of PcoA and anterior communicating artery (AcoA) aneurysms, both integral to the circle of Willis. Read More

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http://jnis.bmj.com/lookup/doi/10.1136/neurintsurg-2018-0144
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http://dx.doi.org/10.1136/neurintsurg-2018-014490DOI Listing
January 2019
9 Reads

Outcomes after coverage of lenticulostriate vessels by flow diverters: a multicenter experience.

J Neurosurg 2019 Jan 11:1-8. Epub 2019 Jan 11.

Departments of1Neurosurgery and.

OBJECTIVEWith the increasing use of flow diversion as treatment for intracranial aneurysms, there is a concomitant increased vigilance in monitoring complications. The low porosity of flow diverters is concerning when the origins of vessels are covered, whether large circle of Willis branches or critical perforators. In this study, the authors report their experience with flow diverter coverage of the lenticulostriate vessels and evaluate their safety and outcomes. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18755DOI Listing
January 2019
2 Reads
3.737 Impact Factor

Submillisievert CT angiography for carotid arteries using wide array CT scanner and latest iterative reconstruction algorithm in comparison with previous generations technologies: Feasibility and diagnostic accuracy.

J Cardiovasc Comput Tomogr 2019 Jan 4. Epub 2019 Jan 4.

Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy. Electronic address:

Objectives: To assess evaluability and diagnostic accuracy of a low dose CT angiography (CTA) protocol for carotid arteries using latest Iterative Reconstruction (IR) algorithm in comparison with standard 100 kVp protocol using previous generation CT and IR.

Materials And Methods: 105 patients, referred for CTA of the carotid arteries were prospectively enrolled in our study and underwent CTA with 80 kVp and latest IR algorithm (group 1). Data were retrospectively compared with 100 consecutive patients with similar examination indications that had previously undergone CTA of carotid arteries with a standard 100 kVp protocol and a first generation IR algorithm (group 2). Read More

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http://dx.doi.org/10.1016/j.jcct.2019.01.009DOI Listing
January 2019
1 Read

Internal Carotid Artery Occlusion Causing Acute Cranial Neuropathies.

J Stroke Cerebrovasc Dis 2019 Jan 9. Epub 2019 Jan 9.

Department of Neurology, Westmead Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

A 54-year-old male with a history of left posterior parietal ischemic stroke, epilepsy, tobacco and marijuana smoking, and alcohol abuse, presented with acute left visual loss and diplopia. On examination, he had reduced left visual acuity and a left oculomotor nerve palsy. CT angiogram from aortic arch to circle of Willis identified extensive thrombus occluding the left common and internal carotid arteries, extending to the left ophthalmic artery. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.017DOI Listing
January 2019

Accuracy of blood flow assessment in cerebral arteries with 4D flow MRI: Evaluation with three segmentation methods.

J Magn Reson Imaging 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Sciences, Umeå University, Umeå, Sweden.

Background: Accelerated 4D flow MRI allows for high-resolution velocity measurements with whole-brain coverage. Such scans are increasingly used to calculate flow rates of individual arteries in the vascular tree, but detailed information about the accuracy and precision in relation to different postprocessing options is lacking.

Purpose: To evaluate and optimize three proposed segmentation methods and determine the accuracy of in vivo 4D flow MRI blood flow rate assessments in major cerebral arteries, with high-resolution 2D PCMRI as a reference. Read More

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http://doi.wiley.com/10.1002/jmri.26641
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http://dx.doi.org/10.1002/jmri.26641DOI Listing
January 2019
7 Reads

Neurosurgical cadaveric and in vivo large animal training models for cranial and spinal approaches and techniques - a systematic review of the current literature.

Neurol Neurochir Pol 2019 7;53(1):8-17. Epub 2019 Jan 7.

Department of Neurosurgery, Iuliu Hatieganu University of Medicine and Pharmacy.

Introduction: Due to its high complexity, neurosurgery consists of a demanding learning curve that requires intense training and a deep knowledge of neuroanatomy. Microsurgical skill development can be achieved through various models of simulation, but as human cadaveric models are not always accessible, cadaveric animal models can provide a reliable environment in which to enhance the acquisition of surgical dexterity. The aim of this review was to analyse the current role of animal brains in laboratory training and to assess their correspondence to the procedures performed in humans. Read More

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http://dx.doi.org/10.5603/PJNNS.a2019.0001DOI Listing
January 2019
3 Reads

Asymmetrical Gadolinium Leakage in Ocular Structures in Stroke Due to Internal Carotid Artery Stenosis or Occlusion.

Clin Neuroradiol 2018 Dec 28. Epub 2018 Dec 28.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

Purpose: Gadolinium leakage in ocular structures (GLOS) on fluid-attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke. The present study sought to investigate the frequency and pattern of blood-retina barrier impairment in acute ischemic stroke due to internal carotid artery (ICA) stenosis or occlusion as demonstrated by GLOS.

Methods: From a magnetic resonance imaging (MRI) report database patients were identified with acute ischemic stroke due to ICA stenosis/occlusion who underwent repeated MRI with intravenous contrast agent administration and FLAIR and MR angiography (MRA). Read More

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http://dx.doi.org/10.1007/s00062-018-0754-5DOI Listing
December 2018

Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.

Arthritis Res Ther 2018 Dec 27;20(1):283. Epub 2018 Dec 27.

Duke Molecular Physiology Institute, Duke University School of Medicine, 300 N Duke St, Durham, NC, 27701, USA.

Background: Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we measured changes in inter-relationships of plasma galectin-3, skeletal muscle cytokines, and muscle myostatin in patients with RA and prediabetes before and after a high-intensity interval training (HIIT) program.

Methods: Previously sedentary persons with either RA (n = 12) or prediabetes (n = 9) completed a 10-week supervised HIIT program. Read More

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http://dx.doi.org/10.1186/s13075-018-1786-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307310PMC
December 2018

Flow diversion treatment of complex bifurcation aneurysms beyond the circle of Willis: complications, aneurysm sac occlusion, reabsorption, recurrence, and jailed branch modification at follow-up.

J Neurosurg 2018 Dec 21:1-12. Epub 2018 Dec 21.

1Service de Neuroradiologie, Hôpital Pierre-Paul Riquet, CHU de Toulouse; and.

OBJECTIVEThe purpose of this study is to present the authors' medium-term results, with special emphasis on complications, occlusion rate of the aneurysm sac (digital subtraction angiography [DSA] and MRI), and the fate of cortical branches and perforating arteries covered ("jailed") by the flow diverter (FD) stent.METHODSBetween January 2010 and September 2017, 29 patients (14 female) with 30 aneurysms were treated with an FD stent. Twenty-one aneurysms were at the middle cerebral artery bifurcation, 8 were in the anterior communicating artery region, and 1 was a pericallosal artery bifurcation. Read More

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http://dx.doi.org/10.3171/2018.7.JNS18654DOI Listing
December 2018
10 Reads
3.737 Impact Factor

Search for Subsolar-Mass Ultracompact Binaries in Advanced LIGO's First Observing Run.

Authors:
B P Abbott R Abbott T D Abbott F Acernese K Ackley C Adams T Adams P Addesso R X Adhikari V B Adya C Affeldt B Agarwal M Agathos K Agatsuma N Aggarwal O D Aguiar L Aiello A Ain P Ajith B Allen G Allen A Allocca M A Aloy P A Altin A Amato A Ananyeva S B Anderson W G Anderson S V Angelova S Antier S Appert K Arai M C Araya J S Areeda M Arène N Arnaud K G Arun S Ascenzi G Ashton M Ast S M Aston P Astone D V Atallah F Aubin P Aufmuth C Aulbert K AultONeal C Austin A Avila-Alvarez S Babak P Bacon F Badaracco M K M Bader S Bae P T Baker F Baldaccini G Ballardin S W Ballmer S Banagiri J C Barayoga S E Barclay B C Barish D Barker K Barkett S Barnum F Barone B Barr L Barsotti M Barsuglia D Barta J Bartlett I Bartos R Bassiri A Basti J C Batch M Bawaj J C Bayley M Bazzan B Bécsy C Beer M Bejger I Belahcene A S Bell D Beniwal M Bensch B K Berger G Bergmann S Bernuzzi J J Bero C P L Berry D Bersanetti A Bertolini J Betzwieser R Bhandare I A Bilenko S A Bilgili G Billingsley C R Billman J Birch R Birney O Birnholtz S Biscans S Biscoveanu A Bisht M Bitossi M A Bizouard J K Blackburn J Blackman C D Blair D G Blair R M Blair S Bloemen O Bock N Bode M Boer Y Boetzel G Bogaert A Bohe F Bondu E Bonilla R Bonnand P Booker B A Boom C D Booth R Bork V Boschi S Bose K Bossie V Bossilkov J Bosveld Y Bouffanais A Bozzi C Bradaschia P R Brady A Bramley M Branchesi J E Brau T Briant F Brighenti A Brillet M Brinkmann V Brisson P Brockill A F Brooks D D Brown S Brunett C C Buchanan A Buikema T Bulik H J Bulten A Buonanno D Buskulic C Buy R L Byer M Cabero L Cadonati G Cagnoli C Cahillane J Calderón Bustillo T A Callister E Calloni J B Camp M Canepa P Canizares K C Cannon H Cao J Cao C D Capano E Capocasa F Carbognani S Caride M F Carney J Casanueva Diaz C Casentini S Caudill M Cavaglià F Cavalier R Cavalieri G Cella C B Cepeda P Cerdá-Durán G Cerretani E Cesarini O Chaibi S J Chamberlin M Chan S Chao P Charlton E Chase E Chassande-Mottin D Chatterjee B D Cheeseboro H Y Chen X Chen Y Chen H-P Cheng H Y Chia A Chincarini A Chiummo T Chmiel H S Cho M Cho J H Chow N Christensen Q Chu A J K Chua S Chua K W Chung S Chung G Ciani A A Ciobanu R Ciolfi F Cipriano C E Cirelli A Cirone F Clara J A Clark P Clearwater F Cleva C Cocchieri E Coccia P-F Cohadon D Cohen A Colla C G Collette C Collins L R Cominsky M Constancio L Conti S J Cooper P Corban T R Corbitt I Cordero-Carrión K R Corley N Cornish A Corsi S Cortese C A Costa R Cotesta M W Coughlin S B Coughlin J-P Coulon S T Countryman P Couvares P B Covas E E Cowan D M Coward M J Cowart D C Coyne R Coyne J D E Creighton T D Creighton J Cripe S G Crowder T J Cullen A Cumming L Cunningham E Cuoco T Dal Canton G Dálya S L Danilishin S D'Antonio K Danzmann A Dasgupta C F Da Silva Costa V Dattilo I Dave M Davier D Davis E J Daw B Day D DeBra M Deenadayalan J Degallaix M De Laurentis S Deléglise W Del Pozzo N Demos T Denker T Dent R De Pietri J Derby V Dergachev R De Rosa C De Rossi R DeSalvo A S Deutsch O de Varona S Dhurandhar M C Díaz L Di Fiore M Di Giovanni T Di Girolamo A Di Lieto B Ding S Di Pace I Di Palma F Di Renzo A Dmitriev Z Doctor V Dolique F Donovan K L Dooley S Doravari I Dorrington M Dovale Álvarez T P Downes M Drago C Dreissigacker J C Driggers Z Du P Dupej S E Dwyer P J Easter T B Edo M C Edwards A Effler H-B Eggenstein P Ehrens J Eichholz S S Eikenberry M Eisenmann R A Eisenstein R C Essick H Estelles D Estevez Z B Etienne T Etzel M Evans T M Evans V Fafone H Fair S Fairhurst X Fan S Farinon B Farr W M Farr E J Fauchon-Jones M Favata M Fays C Fee H Fehrmann J Feicht M M Fejer F Feng A Fernandez-Galiana I Ferrante E C Ferreira F Ferrini F Fidecaro I Fiori D Fiorucci M Fishbach R P Fisher J M Fishner M Fitz-Axen R Flaminio M Fletcher H Fong J A Font P W F Forsyth S S Forsyth J-D Fournier S Frasca F Frasconi Z Frei A Freise R Frey V Frey P Fritschel V V Frolov P Fulda M Fyffe H A Gabbard B U Gadre S M Gaebel J R Gair L Gammaitoni M R Ganija S G Gaonkar A Garcia C García-Quirós F Garufi B Gateley S Gaudio G Gaur V Gayathri G Gemme E Genin A Gennai D George J George L Gergely V Germain S Ghonge Abhirup Ghosh Archisman Ghosh S Ghosh B Giacomazzo J A Giaime K D Giardina A Giazotto K Gill G Giordano L Glover E Goetz R Goetz B Goncharov G González J M Gonzalez Castro A Gopakumar M L Gorodetsky S E Gossan M Gosselin R Gouaty A Grado C Graef M Granata A Grant S Gras C Gray G Greco A C Green R Green E M Gretarsson P Groot H Grote S Grunewald P Gruning G M Guidi H K Gulati X Guo A Gupta M K Gupta K E Gushwa E K Gustafson R Gustafson O Halim B R Hall E D Hall E Z Hamilton H F Hamilton G Hammond M Haney M M Hanke J Hanks C Hanna O A Hannuksela J Hanson T Hardwick J Harms G M Harry I W Harry M J Hart C-J Haster K Haughian J Healy A Heidmann M C Heintze H Heitmann P Hello G Hemming M Hendry I S Heng J Hennig A W Heptonstall F J Hernandez M Heurs S Hild T Hinderer D Hoak S Hochheim D Hofman N A Holland K Holt D E Holz P Hopkins C Horst J Hough E A Houston E J Howell A Hreibi E A Huerta D Huet B Hughey M Hulko S Husa S H Huttner T Huynh-Dinh A Iess N Indik C Ingram R Inta G Intini H N Isa J-M Isac M Isi B R Iyer K Izumi T Jacqmin K Jani P Jaranowski D S Johnson W W Johnson D I Jones R Jones R J G Jonker L Ju J Junker C V Kalaghatgi V Kalogera B Kamai S Kandhasamy G Kang J B Kanner S J Kapadia S Karki K S Karvinen M Kasprzack M Katolik S Katsanevas E Katsavounidis W Katzman S Kaufer K Kawabe N V Keerthana F Kéfélian D Keitel A J Kemball R Kennedy J S Key F Y Khalili B Khamesra H Khan I Khan S Khan Z Khan E A Khazanov N Kijbunchoo Chunglee Kim J C Kim K Kim W Kim W S Kim Y-M Kim E J King P J King M Kinley-Hanlon R Kirchhoff J S Kissel L Kleybolte S Klimenko T D Knowles P Koch S M Koehlenbeck S Koley V Kondrashov A Kontos M Korobko W Z Korth I Kowalska D B Kozak C Krämer V Kringel A Królak G Kuehn P Kumar R Kumar S Kumar L Kuo A Kutynia S Kwang B D Lackey K H Lai M Landry R N Lang J Lange B Lantz R K Lanza A Lartaux-Vollard P D Lasky M Laxen A Lazzarini C Lazzaro P Leaci S Leavey C H Lee H K Lee H M Lee H W Lee K Lee J Lehmann A Lenon M Leonardi N Leroy N Letendre Y Levin J Li T G F Li X Li S D Linker T B Littenberg J Liu X Liu R K L Lo N A Lockerbie L T London A Longo M Lorenzini V Loriette M Lormand G Losurdo J D Lough G Lovelace H Lück D Lumaca A P Lundgren R Lynch Y Ma R Macas S Macfoy B Machenschalk M MacInnis D M Macleod I Magaña Hernandez F Magaña-Sandoval L Magaña Zertuche R M Magee E Majorana I Maksimovic N Man V Mandic V Mangano G L Mansell M Manske M Mantovani F Marchesoni F Marion S Márka Z Márka C Markakis A S Markosyan A Markowitz E Maros A Marquina F Martelli L Martellini I W Martin R M Martin D V Martynov K Mason E Massera A Masserot T J Massinger M Masso-Reid S Mastrogiovanni A Matas F Matichard L Matone N Mavalvala N Mazumder J J McCann R McCarthy D E McClelland S McCormick L McCuller S C McGuire J McIver D J McManus T McRae S T McWilliams D Meacher G D Meadors M Mehmet J Meidam E Mejuto-Villa A Melatos G Mendell D Mendoza-Gandara R A Mercer L Mereni E L Merilh M Merzougui S Meshkov C Messenger C Messick R Metzdorff P M Meyers H Miao C Michel H Middleton E E Mikhailov L Milano A L Miller A Miller B B Miller J Miller M Millhouse J Mills M C Milovich-Goff O Minazzoli Y Minenkov J Ming C Mishra S Mitra V P Mitrofanov G Mitselmakher R Mittleman D Moffa K Mogushi M Mohan S R P Mohapatra M Montani C J Moore D Moraru G Moreno S Morisaki B Mours C M Mow-Lowry G Mueller A W Muir Arunava Mukherjee D Mukherjee S Mukherjee N Mukund A Mullavey J Munch E A Muñiz M Muratore P G Murray A Nagar K Napier I Nardecchia L Naticchioni R K Nayak J Neilson G Nelemans T J N Nelson M Nery A Neunzert L Nevin J M Newport K Y Ng S Ng P Nguyen T T Nguyen D Nichols A B Nielsen S Nissanke A Nitz F Nocera D Nolting C North L K Nuttall M Obergaulinger J Oberling B D O'Brien G D O'Dea G H Ogin J J Oh S H Oh F Ohme H Ohta M A Okada M Oliver P Oppermann Richard J Oram B O'Reilly R Ormiston L F Ortega R O'Shaughnessy S Ossokine D J Ottaway H Overmier B J Owen A E Pace G Pagano J Page M A Page A Pai S A Pai J R Palamos O Palashov C Palomba A Pal-Singh Howard Pan Huang-Wei Pan B Pang P T H Pang C Pankow F Pannarale B C Pant F Paoletti A Paoli M A Papa A Parida W Parker D Pascucci A Pasqualetti R Passaquieti D Passuello M Patil B Patricelli B L Pearlstone C Pedersen M Pedraza R Pedurand L Pekowsky A Pele S Penn C J Perez A Perreca L M Perri H P Pfeiffer M Phelps K S Phukon O J Piccinni M Pichot F Piergiovanni V Pierro G Pillant L Pinard I M Pinto M Pirello M Pitkin R Poggiani P Popolizio E K Porter L Possenti A Post J Powell J Prasad J W W Pratt G Pratten V Predoi T Prestegard M Principe S Privitera G A Prodi L G Prokhorov O Puncken M Punturo P Puppo M Pürrer H Qi V Quetschke E A Quintero R Quitzow-James F J Raab D S Rabeling H Radkins P Raffai S Raja C Rajan B Rajbhandari M Rakhmanov K E Ramirez A Ramos-Buades Javed Rana P Rapagnani V Raymond M Razzano J Read T Regimbau L Rei S Reid D H Reitze W Ren F Ricci P M Ricker K Riles M Rizzo N A Robertson R Robie F Robinet T Robson A Rocchi L Rolland J G Rollins V J Roma R Romano C L Romel J H Romie D Rosińska M P Ross S Rowan A Rüdiger P Ruggi G Rutins K Ryan S Sachdev T Sadecki M Sakellariadou L Salconi M Saleem F Salemi A Samajdar L Sammut L M Sampson E J Sanchez L E Sanchez N Sanchis-Gual V Sandberg J R Sanders N Sarin B Sassolas B S Sathyaprakash P R Saulson O Sauter R L Savage A Sawadsky P Schale M Scheel J Scheuer P Schmidt R Schnabel R M S Schofield A Schönbeck E Schreiber D Schuette B W Schulte B F Schutz S G Schwalbe J Scott S M Scott E Seidel D Sellers A S Sengupta D Sentenac V Sequino A Sergeev Y Setyawati D A Shaddock T J Shaffer A A Shah M S Shahriar M B Shaner L Shao B Shapiro P Shawhan H Shen D H Shoemaker D M Shoemaker K Siellez X Siemens M Sieniawska D Sigg A D Silva L P Singer A Singh A Singhal A M Sintes B J J Slagmolen T J Slaven-Blair B Smith J R Smith R J E Smith S Somala E J Son B Sorazu F Sorrentino T Souradeep A P Spencer A K Srivastava K Staats M Steinke J Steinlechner S Steinlechner D Steinmeyer B Steltner S P Stevenson D Stocks R Stone D J Stops K A Strain G Stratta S E Strigin A Strunk R Sturani A L Stuver T Z Summerscales L Sun S Sunil J Suresh P J Sutton B L Swinkels M J Szczepańczyk M Tacca S C Tait C Talbot D Talukder D B Tanner M Tápai A Taracchini J D Tasson J A Taylor R Taylor S V Tewari T Theeg F Thies E G Thomas M Thomas P Thomas K A Thorne E Thrane S Tiwari V Tiwari K V Tokmakov K Toland M Tonelli Z Tornasi A Torres-Forné C I Torrie D Töyrä F Travasso G Traylor J Trinastic M C Tringali L Trozzo K W Tsang M Tse R Tso D Tsuna L Tsukada D Tuyenbayev K Ueno D Ugolini A L Urban S A Usman H Vahlbruch G Vajente G Valdes N van Bakel M van Beuzekom J F J van den Brand C Van Den Broeck D C Vander-Hyde L van der Schaaf J V van Heijningen A A van Veggel M Vardaro V Varma S Vass M Vasúth A Vecchio G Vedovato J Veitch P J Veitch K Venkateswara G Venugopalan D Verkindt F Vetrano A Viceré A D Viets S Vinciguerra D J Vine J-Y Vinet S Vitale T Vo H Vocca C Vorvick S P Vyatchanin A R Wade L E Wade M Wade R Walet M Walker L Wallace S Walsh G Wang H Wang J Z Wang W H Wang Y F Wang R L Ward J Warner M Was J Watchi B Weaver L-W Wei M Weinert A J Weinstein R Weiss F Wellmann L Wen E K Wessel P Weßels J Westerweck K Wette J T Whelan B F Whiting C Whittle D Wilken D Williams R D Williams A R Williamson J L Willis B Willke M H Wimmer W Winkler C C Wipf H Wittel G Woan J Woehler J K Wofford W K Wong J Worden J L Wright D S Wu D M Wysocki S Xiao W Yam H Yamamoto C C Yancey L Yang M J Yap M Yazback Hang Yu Haocun Yu M Yvert A Zadrożny M Zanolin T Zelenova J-P Zendri M Zevin J Zhang L Zhang M Zhang T Zhang Y-H Zhang C Zhao M Zhou Z Zhou S J Zhu X J Zhu M E Zucker J Zweizig S Shandera

Phys Rev Lett 2018 Dec;121(23):231103

The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

We present the first Advanced LIGO and Advanced Virgo search for ultracompact binary systems with component masses between 0.2  M_{⊙}-1.0  M_{⊙} using data taken between September 12, 2015 and January 19, 2016. Read More

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http://dx.doi.org/10.1103/PhysRevLett.121.231103DOI Listing
December 2018
13 Reads

Cystatin C Expression is Promoted by VEGFA Blocking, With Inhibitory Effects on Endothelial Cell Angiogenic Functions Including Proliferation, Migration, and Chorioallantoic Membrane Angiogenesis.

J Am Heart Assoc 2018 Nov;7(21):e009167

1 School of Basic Medical Sciences Capital Medical University Beijing Key Laboratory of Cancer Invasion & Metastasis Research Beijing China.

Background Vascular development, including vasculogenesis and angiogenesis, is involved in many diseases. Cystatin C ( CST 3) is a commonly used marker of renal dysfunction, and we have previously reported that its expression level is associated with variations in the gerbil circle of Willis. Thus, we hypothesized that CST 3 may affect endothelial function and angiogenic capacity. Read More

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http://dx.doi.org/10.1161/JAHA.118.009167DOI Listing
November 2018
2.882 Impact Factor

Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.

Acta Neuropathol Commun 2018 12 19;6(1):142. Epub 2018 Dec 19.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.

TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific anatomic regions. To examine the comorbidities associated with TDP-43 pathology in aged individuals, we studied data from the National Alzheimer's Coordinating Center (NACC) Neuropathology Data Set. Read More

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http://dx.doi.org/10.1186/s40478-018-0641-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299605PMC
December 2018
2 Reads

Completeness of circle of Willis and white matter hyperintensities in patients with severe internal carotid artery stenosis.

Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.

Cerebrovascular Disease Center, Department of Neurology, People's Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.

Background: We investigated whether completeness of the circle of Willis (CoW) protected patients with severe internal carotid artery (ICA) stenosis against white matter hyperintensities (WMHs).

Methods: We included 115 patients with unilateral ICA stenosis ≥ 70%. The completeness of CoW was assessed and WMHs were rated on a visual scale. Read More

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http://dx.doi.org/10.1007/s10072-018-3683-9DOI Listing
December 2018

Bilateral Cerebrovascular Stroke as an Initial Presenting Symptom of Moyamoya Disease.

Case Rep Crit Care 2018 13;2018:2591494. Epub 2018 Nov 13.

Lincoln Medical and Mental Health Center, 234 E 149Th St., Bronx, NY 10451, USA.

Moyamoya disease is a rare condition affecting the circle of Willis and its branching arteries. While the pathogenesis is unclear, it causes progressive occlusion of multiple cerebral vessels leading to severe strokes. We report a case of a 47-year-old Hispanic woman with HTN presented with altered mental status and bilateral upper and lower extremity weakness with dystonic-like upper extremity movement. Read More

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http://dx.doi.org/10.1155/2018/2591494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260547PMC
November 2018

[Efficacy of carotid endarterectomy in patients with vertebrobasilar insufficiency without significant lesion of vertebral arteries].

Angiol Sosud Khir 2018;24(4):104-108

Clinic of Faculty Surgery, Samara State Medical University of the RF Ministry of Public Health, Samara, Russia.

The authors examined efficacy of carotid endarterectomy (CEA) in treatment of patients suffering from vertebrobasilar insufficiency (VBI) without significant involvement of the vertebral arteries. The study included a total of 297 patients with VBI and diagnosed as having stenosis of the bifurcation of the carotid arteries amounting to 70% and more, with no significant involvement of the vertebral arteries revealed. All patients underwent CEA: eversion CEA was performed in 226 (76. Read More

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February 2019
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Assessment of the Prevalence of Vascular Anomalies of the Circle of Willis Based on the Autopsy of Cadavers in Kurdish Race Between 2016 and 2017.

Mater Sociomed 2018 Oct;30(3):189-192

Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Cerebral arterial variations are commonly associated with cerebrovascular disease and should be considered during brain surgeries. Since some cerebrovascular diseases are seen in certain breeds, it seems that different distributions of cerebral arterial variations depend on race.

Aim: The aim of this study was to determine the random incidence of vascular anomalies of the circle of Willis in autopsy of the cadavers. Read More

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http://dx.doi.org/10.5455/msm.2018.30.189-192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195410PMC
October 2018
2 Reads

9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics.

Curr Neurovasc Res 2018 ;15(4):312-325

Cannon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY 14260, United States.

Background: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW).

Method: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left Common Carotid Artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries. Read More

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http://dx.doi.org/10.2174/1567202616666181127165943DOI Listing
January 2018
3 Reads

The probability of incomplete or hypoplastic circle of Willis (Reply).

Ann Thorac Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatric Cardiac Surgery and Pediatrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-NürnbergLoschgestraße 15, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.athoracsur.2018.10.039DOI Listing
November 2018

Reproducibility of the fetal cerebral vessels assessment in full and late term pregnancies.

J Matern Fetal Neonatal Med 2018 Nov 25:1-7. Epub 2018 Nov 25.

b Servicio de Obstetricia , Hospital Universitario y Politécnico La Fe , Valencia , Spain.

Objective: Data concerning feasibility of the fetal cerebral Doppler examination in full term and late term pregnancy is lacking. Our purpose was to perform an evaluation of these arteries with power Doppler ultrasound, calculating the percentage of identification and measurement and the intraobserver reproducibility.

Methods: This was a cross sectional study evaluating a population of 578 normally grown fetuses divided according to the week of examination. Read More

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http://dx.doi.org/10.1080/14767058.2018.1542681DOI Listing
November 2018
1 Read

Endovascular Treatment for Vasospasm after Aneurysmal Subarachnoid Hemorrhage Based on Data of JR-NET3.

Neurol Med Chir (Tokyo) 2018 Dec 21;58(12):495-502. Epub 2018 Nov 21.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University.

Endovascular treatments for vasospasm after subarachnoid hemorrhage are typically performed for patients who are refractory to recommended medical therapies. We analyzed the current status of endovascular treatments based on the data of Japanese Registry of Neuroendovascular Therapy (JR-NET)3, and evaluated factors related to improvement of imaging findings and neurological condition, and to mechanical hemorrhage complications. We collected data of 1211 treatments performed from 2010 to 2014. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300693PMC
December 2018
12 Reads