3,388 results match your criteria Circle of Willis


Improved reperfusion following alternative surgical approach for experimental stroke in mice.

F1000Res 2020 13;9:188. Epub 2020 Mar 13.

School of Psychology, University of Nottingham, Nottingham, NG7 2UH, UK.

: Following ischemic stroke, recanalisation and restoration of blood flow to the affected area of the brain is critical and directly correlates with patient recovery.  models of ischemic stroke show high variability in outcomes, which may be due to variability in reperfusion.  We previously reported that a surgical refinement in the middle cerebral artery occlusion (MCAO) model of stroke, via repair of the common carotid artery (CCA), removes the reliance on the Circle of Willis for reperfusion and reduced infarct variability. Read More

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http://dx.doi.org/10.12688/f1000research.22594.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217225PMC

Predictors of Successful First-Pass Thrombectomy with a Balloon Guide Catheter: Results of a Decision Tree Analysis.

Transl Stroke Res 2020 May 23. Epub 2020 May 23.

Department of Clinical Radiology, Institute of Clinical Radiology and Neuroradiology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Complete recanalization after a single retrieval maneuver is an interventional goal in acute ischemic stroke and an independent factor for good clinical outcome. Anatomical biomarkers for predicting clot removal difficulties have not been comprehensively analyzed and await unused. We retrospectively evaluated 200 consecutive patients who suffered acute stroke and occlusion of the anterior circulation and were treated with mechanical thrombectomy through a balloon guide catheter (BGC). Read More

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http://dx.doi.org/10.1007/s12975-020-00784-2DOI Listing

Rare transsellar collateral artery and secondary ophthalmic artery aneurysm in young adult with ICA aplasia.

World Neurosurg 2020 May 12. Epub 2020 May 12.

Cooper Neurologic Institute, Cooper University Hospital, Camden, NJ 08103.

ICA aplasia is a rare congenital abnormality in which the third aortic arch fails to develop. The majority of collateral circulation originates for the Circle of Willis, with other sites being rare. Changes in flow through the collateral vasculature result in aneurysm formation at a young age. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.021DOI Listing

The role of MRA in pediatric sickle cell disease with normal transcranial Doppler imaging velocities.

J Stroke Cerebrovasc Dis 2020 May 10:104864. Epub 2020 May 10.

Pediatric Neuroradiology and Image Guided Therapy, Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto M5G 1H4, ON, Canada.

Purpose: The purpose of this study was to determine the additional information provided by Magnetic Resonance Angiography (MRA) in pediatric sickle cell disease (SCD) patients with normal Transcranial Doppler imaging (TCDI) examinations.

Methods: This cohort study included all pediatric SCD patients over an 18-year period who had no history of stroke and had normal TCDI examinations and subsequently underwent MRA. Routine TCDI inclusive of time-averaged mean of maximum velocities (TAMMV) were assesses and compared with tortuosity on MRA and silent infarct on MRI. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104864DOI Listing

Aneurysmal subarachnoid haemorrhage with a normal computed tomography within 6 h of onset of headache and normal computed tomography Circle of Willis angiography.

Emerg Med Australas 2020 May 12. Epub 2020 May 12.

Emergency Department, Nepean Hospital, Penrith, New South Wales, Australia.

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http://dx.doi.org/10.1111/1742-6723.13539DOI Listing

Design and Physical Properties of 3-Dimensional Printed Models Used for Neurointervention: A Systematic Review of the Literature.

Neurosurgery 2020 May 11. Epub 2020 May 11.

Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.

Background: Three-dimensional (3D) printing has revolutionized training, education, and device testing. Understanding the design and physical properties of 3D-printed models is important.

Objective: To systematically review the design, physical properties, accuracy, and experimental outcomes of 3D-printed vascular models used in neurointervention. Read More

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http://dx.doi.org/10.1093/neuros/nyaa134DOI Listing

Pencil beam scanning proton therapy for the treatment of craniopharyngioma complicated with radiation-induced cerebral vasculopathies: a dosimetric and linear energy transfer (LET) evaluation.

Radiother Oncol 2020 May 5. Epub 2020 May 5.

Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland; Department of Radiation Oncology, University Hospital of Zürich, Zürich, CH-8000, Switzerland; Department of Radiation Oncology, University Hospital of Bern, Bern, CH-3010, Switzerland.

Background And Purpose: This study analyses the dosimetric and dose averaged Linear Energy transfer (LETd) correlation in paediatric craniopharyngioma (CP) patients with and without radiation-induced cerebral vasculopathies (RICVs) treated with pencil beam scanning (PBS) proton therapy (PT).

Material And Methods: We reviewed a series of 16 CP patients treated with PT to a median dose of 54 Gy(RBE). Two (12. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.04.052DOI Listing
May 2020
4.363 Impact Factor

Location-based treatment of intracranial aneurysms in moyamoya disease: a systematic review and descriptive analysis.

Neurosurg Rev 2020 May 8. Epub 2020 May 8.

Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

We conducted a systematic review of the literature to evaluate the efficacy of various treatment modalities for intracranial aneurysms (IA) in patients with moyamoya disease (MMD) based on anatomical location of IA. A comprehensive review of studies documenting single cases or series of MMD patients with concomitant IA was conducted. Aneurysms were classified into two primary anatomical categories: those of the Circle of Willis (CoW) and those of peripheral "moyamoya" collateral vessels. Read More

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http://dx.doi.org/10.1007/s10143-020-01307-1DOI Listing

The intracranial vasculature of canines represents a model for neurovascular ischemia and training residents and fellows in endovascular neurosurgery.

Neuroradiol J 2020 May 5:1971400920920787. Epub 2020 May 5.

New Era Stroke Care and Research Institute, The PLA Rocket Force General Hospital, Beijing, China.

Background: We describe use of a canine model to evaluate physiological effects and neuroprotective strategies in the setting of cerebral ischemia and endovascular neurosurgery training.

Methods: We performed transfemoral digital subtraction cerebral and cervical angiography on eight anesthetized dogs. Angiographic images of cerebral arteries were obtained following cannulation of the femoral artery. Read More

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http://dx.doi.org/10.1177/1971400920920787DOI Listing

Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment.

Biochem Pharmacol 2020 Apr 28;177:114004. Epub 2020 Apr 28.

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; National Institute of Mental Health, Klecany, Czech Republic. Electronic address:

Gestational methylazoxymethanol acetate (MAM) treatment produces offspring with adult phenotype relevant to schizophrenia, including positive- and negative-like symptoms, cognitive deficits, dopaminergic dysfunction, structural and functional abnormalities. Here we show that adult rats prenatally treated with MAM at gestational day 17 display significant increase in dopamine D3 receptor (D3) mRNA expression in prefrontal cortex (PFC), hippocampus and nucleus accumbens, accompanied by increased expression of dopamine D2 receptor (D2) mRNA exclusively in the PFC. Furthermore, a significant change in the blood perfusion at the level of the circle of Willis and hippocampus, paralleled by the enlargement of lateral ventricles, was also detected by magnetic resonance imaging (MRI) techniques. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114004DOI Listing

Surgical correction of coarctation of the aorta featuring an incomplete circle of Willis.

Interact Cardiovasc Thorac Surg 2020 May;30(5):794-795

Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan.

Although devastating complications during simple coarctation of aorta repair now occur less frequently, some unique cases still require extra caution. Here, we report a case of coarctation of the aorta with a rare anomaly in the circle of Willis and an aberrant right subclavian artery, which required a thorough surgical strategy that prevented cerebral malperfusion. Read More

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http://dx.doi.org/10.1093/icvts/ivaa016DOI Listing

Bilateral internal carotid artery occlusion with compensatory perfusion in a HIV-infected patient.

S Afr J Surg 2020 Mar;58(1):44

Division of Neurosurgery, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa.

Summary: HIV infection occlusive arteriopathies may result in neurological symptoms. We report a case of bilateral complete occlusion of the extracranial portions of the internal carotid arteries in a HIV+ve patient who presented with a syncopal episode due to intraventricular haemorrhage. Compensatory blood flow from the posterior cerebral circulation via the circle of Willis resulted in small telangiectatic vessels arising from the posterior cerebral circulation which probably accounted for this rare haemorrhagic complication of an occlusive arteriopathy. Read More

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Intracranial Aneurysms in White Patients with Moyamoya Disease: A U.S. Single-Center Case Series and Review.

World Neurosurg 2020 Mar 19. Epub 2020 Mar 19.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Intracranial aneurysms (IA) are associated with moyamoya disease (MMD). There are no clinically tested treatment guidelines. Reporting of cases is vital to better understand the underlying pathophysiology and potential ethnic predispositions and improve patient selection for intervention. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.072DOI Listing

Vascular Ehlers-Danlos Syndrome: Literature review and surgical management of intracranial vascular complications.

Clin Neurol Neurosurg 2020 Jun 3;193:105775. Epub 2020 Mar 3.

Department of Neurosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom.

Vascular Ehlers-Danlos (vEDS) is a rare form of the Ehlers-Danlos Syndrome (EDS) where arterial fragility results from mutations in the gene that encodes type III collagen. The disease can lead to major neurological complications including carotico-cavernous fistulae (CCF), aneurysms of the Circle of Willis and endovascular procedures have an increased risk profile due to the delicate vasculature. Management of intracranial disease in vEDS requires an intricate understanding of the syndrome but is still associated with significant complications that lead to morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105775DOI Listing
June 2020
1.248 Impact Factor

Cerebral venous congestion correlates to acute aneurysm rupture: An illustrative case with Doppler ultrasonography study.

eNeurologicalSci 2020 Jun 21;19:100231. Epub 2020 Feb 21.

UOC of Neurology, Hospital S. Benedetto del Tronto, AP, Italy.

Background: The objective of our description is to shed light on some new hemodynamic and clinical characteristics in the unstable cerebral aneurysm Case: We describe a 54 year old woman who presented a tension headache, that increasing for several days. A CT scan performed in ER suggests a possible arterial ectasia at the level of the circle of Willis. The patient is hospitalized. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066058PMC

Demographic age-related variation in Circle of Willis completeness assessed by digital subtraction angiography.

Brain Circ 2020 Jan-Mar;6(1):31-37. Epub 2020 Feb 18.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: Incomplete circle of Willis (CoW) configuration is an important risk factor for cerebrovascular pathology, namely aneurysm formation and ischemic stroke. This study was performed to characterize CoW variation using digital subtraction angiography and to identify demographic and physiologic features that may influence the risk of having an incomplete CoW configuration.

Materials And Methods: A retrospective review of 274 patients who underwent cerebral angiography by a single surgeon for any indication was conducted. Read More

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http://dx.doi.org/10.4103/bc.bc_43_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045533PMC
February 2020

Circle of Willis abnormalities and their clinical importance in ageing brains: A cadaveric anatomical and pathological study.

J Chem Neuroanat 2020 Mar 9;106:101772. Epub 2020 Mar 9.

Interdisciplinary Center for Innovation in Biotechnology & Neuroscience, Genetic Diagnostic & Research Laboratory and Human Brain Tissue and DNA Repository, Dept. Anatomy, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka; EURON - European Graduate School of Neuroscience, Maastricht, The Netherlands. Electronic address:

The circle of Willis (CW) located at the base of the brain forms an important collateral network to maintain adequate cerebral perfusion, especially in clinical situations requiring compensatory changes in blood flow. Morphopathological changes in the CW may relate to the severity of the symptoms of certain neurodegenerative and cerebrovascular disorders. The purpose of this study was to investigate the CW abnormalities and their clinical importance in ageing brains. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101772DOI Listing

Examination of Structural Variations of the Circle of Willis by 3D Time-of-Flight Magnetic Resonance Angiography.

Front Neurosci 2020 11;14:71. Epub 2020 Feb 11.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

To explore structural variations of the circle of Willis using three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to compare this modality with digital subtraction angiography (DSA). A total of 819 consecutive patients suspected of having cerebral vascular diseases underwent 3D-TOF-MRA, followed by DSA within 2 weeks. We report accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 3D-TOF-MRA compared with DSA. Read More

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http://dx.doi.org/10.3389/fnins.2020.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026468PMC
February 2020

The application of the single branch-first combined with the mid-arch clamping technique and the embedded anastomosis technique for DeBakey type II aortic dissection.

J Cardiothorac Surg 2020 Feb 22;15(1):38. Epub 2020 Feb 22.

Division of Cardiac Surgery, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Affiliated Hospital of Shandong University, Jinan, Shandong, China, 16766 Jingshi Road, Jinan, 250014, Shandong, China.

Background: Patients with DeBakey type II aortic dissection or ascending aortic aneurysms involving the right innominate artery require hemiarch replacement and placement of a right innominate artery graft. Traditional aortic hemiarch replacement surgery must be performed under right axillary artery cannulation perfusion and moderate or deep hypothermia circulatory arrest. However, the axillary artery perfusion is always associated with left subclavian artery "steal blood", and it cannot guarantee blood supply to the left cerebral hemisphere in patients with an incomplete circle of Willis, and hypothermia and hypoperfusion cause damage to the brain and spinal cord; therefore, postoperative complications of the nervous system are common. Read More

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http://dx.doi.org/10.1186/s13019-020-1082-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036187PMC
February 2020

Automated Grading of Cerebral Vasospasm to Standardize Computed Tomography Angiography Examinations After Subarachnoid Hemorrhage.

Front Neurol 2020 30;11:13. Epub 2020 Jan 30.

Department of Neurosurgery, University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.

Computed tomography angiography (CTA) is frequently used with computed tomography perfusion imaging (CTP) to evaluate whether endovascular vasospasm treatment is indicated for subarachnoid hemorrhage patients with delayed cerebral ischemia. However, objective parameters for CTA evaluation are lacking. In this study, we used an automated, investigator-independent, digital method to detect vasospasm, and we evaluated whether the method could predict the need for subsequent endovascular vasospasm treatment. Read More

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http://dx.doi.org/10.3389/fneur.2020.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002561PMC
January 2020

Surface Point Cloud Ultrasound with Transcranial Doppler: Coregistration of Surface Point Cloud Ultrasound with Magnetic Resonance Angiography for Improved Reproducibility, Visualization, and Navigation in Transcranial Doppler Ultrasound.

J Digit Imaging 2020 Feb 19. Epub 2020 Feb 19.

Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.

Transcranial Doppler (TCD) ultrasound is a standard tool used in the setting of recent sub-arachnoid hemorrhage (SAH). By tracking velocity in the circle-of-Willis vessels, vasospasm can be detected as interval velocity increase. For this disease process, repeated TCD velocity measurements over many days is the basis for its usefulness. Read More

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http://dx.doi.org/10.1007/s10278-020-00328-yDOI Listing
February 2020

Basilar tip aneurysm Wingspan stent-assisted coil embosurgery via P1 to P1 approach.

Proc (Bayl Univ Med Cent) 2020 Jan 14;33(1):87-89. Epub 2019 Oct 14.

Department of Neurosurgery, Baylor Scott and White Medical CenterTempleTexas.

Wide neck basilar tip aneurysms are challenging to secure with coil embosurgery despite balloon remodeling and stent-assisted coiling. In patients with favorable posterior circle of Willis anatomy, the traditional antegrade placement of two stents that span the basilar apex to both proximal posterior cerebral arteries (P1s) can be avoided by implanting a single stent across the P1s and basilar apex via a retrograde posterior communicating artery approach. This case report details the first use of the high radial force Wingspan stent placed in this fashion during basilar aneurysm coiling repair. Read More

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http://dx.doi.org/10.1080/08998280.2019.1673921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988618PMC
January 2020

Evaluation of an acetated Ringer-based contrast material mixture for postmortem computed tomography angiography.

Diagn Interv Imaging 2020 Jan 29. Epub 2020 Jan 29.

Clinic for Radiology and Nuclear Medicine, Cantonal Hospital Saint-Gallen, 9007 Saint-Gallen, Switzerland; Institute of Forensic Medicine, Virtopsy, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

Purpose: The purpose of this study was to compare an established postmortem contrast medium mixture based on polyethylene glycol (PEG) to an isotonic crystalloid with acetated Ringer solution (AR) as the base, both mixed with water-soluble iodinated contrast medium for postmortem computed tomography angiography (PMCTA) with the aim to avoid alterations of the corpse during autopsy.

Materials And Methods: The study included 20 cadavers; 10 had PMCTA with AR and 10 with PEG. PMCTA images were analyzed with respect to image quality, vascular contrast patterns and artifacts. Read More

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http://dx.doi.org/10.1016/j.diii.2020.01.009DOI Listing
January 2020

Carotid near-occlusion is often overlooked when CT angiography is assessed in routine practice.

Eur Radiol 2020 May 31;30(5):2543-2551. Epub 2020 Jan 31.

Department of Medical Imaging, Sunnybrook Health Science Center, University of Toronto, Toronto, Canada.

Objective: Assess the sensitivity and specificity of computed tomography angiography (CTA) for carotid near-occlusion diagnosis interpreted in clinical practice against expert assessment.

Methods: CTAs were graded by two expert interpreters for near-occlusion. Findings were compared with clinical reports in 383 consecutive cases with symptomatic ≥ 50% carotid stenosis. Read More

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http://dx.doi.org/10.1007/s00330-019-06636-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160198PMC

Supraorbital Keyhole Approach for Resection of Prechiasmatic Craniopharyngioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Jan 29. Epub 2020 Jan 29.

Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland.

Craniopharyngioma are benign extra-axial tumors occurring classically in the vicinity of the sella. Because of the complex anatomy surrounding the sella turcica comprising, among others, the vessels of the circle of Willis, the optic nerves, chiasma and optic pathway, the hypothalamus, the third ventricle, and the pituitary gland, a large variety of technical approaches have been described. We illustrate, in this video, a unilateral supraorbital keyhole approach to access and entirely extirpate a prechiasmatic craniopharyngioma. Read More

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http://dx.doi.org/10.1093/ons/opz428DOI Listing
January 2020

Treatment of complex intracranial pathologies with transcirculation endovascular approaches.

Neurocirugia (Astur) 2020 Jan 24. Epub 2020 Jan 24.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Object: The breadth and complexity of neurovascular pathologies treated with endovascular neurosurgery has expanded dramatically in recent years. Many aneurysms remain difficult to treat safely. Transcirculation (contralateral and/or retrograde) approaches through the circle of Willis are useful alternatives for treating challenging lesions endovascularly. Read More

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http://dx.doi.org/10.1016/j.neucir.2019.10.003DOI Listing
January 2020

Subacute Stroke in a Young Female: A Case of Moyamoya Syndrome Initially Anchoring with Anxiety.

Case Rep Med 2019 10;2019:7919568. Epub 2019 Dec 10.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

Moyamoya disease is an arterial disorder causing stroke in a young patient. This is a chronic condition causing progressive cerebrovascular disease due to bilateral stenosis and occlusion of the arteries around the circle of Willis, with prominent arterial collateral circulation. It was first described in Japan and subsequently reported in other Asian countries, but infrequently found in the Western world. Read More

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http://dx.doi.org/10.1155/2019/7919568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925758PMC
December 2019

Bihemisphere Ischemia Due to a Unilateral Lesion: A Case Report.

J Stroke Cerebrovasc Dis 2020 Apr 26;29(4):104590. Epub 2019 Dec 26.

Department of Neurology, University of California, Irvine, California. Electronic address:

Bihemispheric ischemic strokes secondary to unilateral vessel disease are uncommon. We present the case of a 70-year-old man with multiple acute/subacute bilateral infarcts. The patient was found to have stenosis of the left internal carotid artery secondary to herpes zoster ophthalmicus vasculopathy, with involvement of the left proximal middle and anterior cerebral arteries. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104590DOI Listing

Neuropsychological profile associated with moyamoya disease: A case report.

NeuroRehabilitation 2020 May 26. Epub 2020 May 26.

Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Moyamoya disease (MMD) is a rare cardiovascular condition characterized by stenosis and gradual occlusion of the Internal Carotid Arteries near the circle of Willis. Current research on the disease has primarily been restricted to its medical implications, without adequate appreciation for its neurocognitive and/or neuropsychiatric implications.

Objectives: The current study presents the neurocognitive profile of a 31-year-old woman diagnosed with MMD, further complicated by cerebral vascular accidents (CVAs) and history of bilateral craniotomy aimed at providing maximal revascularization. Read More

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http://dx.doi.org/10.3233/NRE-192903DOI Listing

Duplication of Intracavernous Internal Carotid Artery.

Acta Neurol Taiwan 2019 Jun;28(2):57-58

Department of Diagnostic Imaging-Interventional Radiology Unit E.O. Galliera Hospital, Mura delle Cappuccine, 14-16128 Genova, ITALY.

ation. No significant past medical history except for pharmacologically controlled mild hypertension. During the neurological examination the patient appeared alert, oriented and showed no deficit of strength, sensitivity and coordination. Read More

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Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study.

AJNR Am J Neuroradiol 2019 12 5;40(12):2016-2022. Epub 2019 Dec 5.

From the Department of Radiology (M.H.T.Z., R.G., J.H., A.G.v.d.K.).

Background And Purpose: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease. Read More

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http://dx.doi.org/10.3174/ajnr.A6308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975353PMC
December 2019

Bilateral central retinal/ophthalmic artery occlusion and near-complete ophthalmoplegia after bilateral lung transplant.

Am J Ophthalmol Case Rep 2019 Dec 11;16:100569. Epub 2019 Nov 11.

School of Medicine, National University of Ireland, Galway, Ireland.

Purpose: Recognize a rare yet existing risk of severe visual loss as a postoperative complication of bilateral lung transplant.

Observations: A 62-year-old male had undergone bilateral lung transplant for end-stage idiopathic pulmonary fibrosis and emphysema overlap syndrome. The operation was initially off-pump; however, during the left lung transplantation, cardiopulmonary bypass conversion was necessary to maintain intraoperative hemodynamic stability. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.100569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880121PMC
December 2019

Selective angiography with the possibility of thrombolysis in patients with central retinal artery occlusion.

Cesk Slov Oftalmol 2019 ;75(3):152-159

Purpose: Describe the clinical finding and course of treatment in patients with a sudden decrease in visual function due to an acute occlusion of the arteria centralis retinae. Patients were primarily indicated for selective angiography with thrombolysis of the ophthalmic artery.

Materials And Methods: Medical documentation of two patients with acute central retinal artery occlusion with a time duration of up to 5 hours was evaluated retrospectively. Read More

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http://dx.doi.org/10.31348/2019/3/6DOI Listing
December 2019

Cost and Utility of Routine Contrast-Enhanced Neck MRA in a Pediatric MRI Stroke Evaluation Protocol.

AJNR Am J Neuroradiol 2019 12 14;40(12):2143-2145. Epub 2019 Nov 14.

Section of Child Neurology, Department of Radiology (D.M., J.M., I.N., L.F., N.S.)

Background And Purpose: Cervical arterial dissection is one of the frequent causes of pediatric arterial ischemic stroke. Out of concern for missing cervical arterial dissection in patients in whom pediatric stroke is suspected, our tertiary children's hospital added contrast-enhanced 3D neck MR angiography to every pediatric stoke work-up. This research investigated whether the routine use of contrast-enhanced neck MRA in our MR imaging stroke protocol ever detected a cervical arterial abnormality when the DWI, SWI/gradient recalled-echo, or circle of Willis MRA findings from the brain MR imaging were reported as normal. Read More

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http://dx.doi.org/10.3174/ajnr.A6315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975355PMC
December 2019

Assessment of Cerebral Blood Flow Pulsatility and Cerebral Arterial Compliance With 4D Flow MRI.

J Magn Reson Imaging 2020 May 12;51(5):1516-1525. Epub 2019 Nov 12.

Department of Radiation Sciences, Umeå University, Umeå, Sweden.

Background: Four-dimensional flow magnetic resonance imaging (4D flow MRI) enables efficient investigation of cerebral blood flow pulsatility in the cerebral arteries. This is important for exploring hemodynamic mechanisms behind vascular diseases associated with arterial pulsations.

Purpose: To investigate the feasibility of pulsatility assessments with 4D flow MRI, its agreement with reference two-dimensional phase-contrast MRI (2D PC-MRI) measurements, and to demonstrate how 4D flow MRI can be used to assess cerebral arterial compliance and cerebrovascular resistance in major cerebral arteries. Read More

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http://dx.doi.org/10.1002/jmri.26978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216927PMC

Blood flow rate and wall shear stress in seven major cephalic arteries of humans.

J Anat 2020 Mar 11;236(3):522-530. Epub 2019 Nov 11.

Department of Anatomy and Physiology, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Blood flow rate ( ) in relation to arterial lumen radius (r ) is commonly modelled according to theoretical equations and paradigms, including Murray's Law ( ∝ ) and da Vinci's Rule ( ∝ ). Wall shear stress (τ) is independent of r with Murray's Law (τ ∝  ) and decreases with da Vinci's Rule (τ ∝  ). These paradigms are tested empirically with a meta-analysis of the relationships between and r in seven major arteries of the human cephalic circulation from 19 imaging studies in which both variables were presented. Read More

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http://dx.doi.org/10.1111/joa.13119DOI Listing

Atherosclerotic ICA stenosis coinciding with ICA asymmetry associated with Circle of Willis variations can mimic near-occlusion.

Neuroradiology 2020 Jan 8;62(1):101-104. Epub 2019 Nov 8.

Department of Medical Imaging, Sunnybrook Health Science Center, University of Toronto, Toronto, Canada.

Differentiating carotid near-occlusion (tight atherosclerotic stenosis causing distal artery size reduction) from conventional stenosis is the first step when grading carotid stenoses with NASCET method. The internal carotid artery (ICA) can be asymmetrically associated with Circle of Willis variations. When such ICA asymmetry coincides with stenosis, it may mimic near-occlusion. Read More

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http://dx.doi.org/10.1007/s00234-019-02309-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940316PMC
January 2020

Repaired coarctation of the aorta, persistent arterial hypertension and the selfish brain.

J Cardiovasc Magn Reson 2019 11 7;21(1):68. Epub 2019 Nov 7.

School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Science, University of Bristol, Bristol, UK.

Background: It has been estimated that 20-30% of repaired aortic coarctation (CoA) patients develop hypertension, with significant cardiovascular morbidity and mortality. Vertebral artery hypoplasia (VAH) with an incomplete posterior circle of Willis (ipCoW; VAH + ipCoW) is associated with increased cerebrovascular resistance before the onset of increased sympathetic nerve activity in borderline hypertensive humans, suggesting brainstem hypoperfusion may evoke hypertension to maintain cerebral blood flow: the "selfish brain" hypothesis. We now assess the "selfish brain" in hypertension post-CoA repair. Read More

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http://dx.doi.org/10.1186/s12968-019-0578-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839237PMC
November 2019

Search for Subsolar Mass Ultracompact Binaries in Advanced LIGO's Second Observing Run.

Authors:
B P Abbott R Abbott T D Abbott S Abraham F Acernese K Ackley C Adams R X Adhikari V B Adya C Affeldt M Agathos K Agatsuma N Aggarwal O D Aguiar L Aiello A Ain P Ajith G Allen A Allocca M A Aloy P A Altin A Amato S Anand A Ananyeva S B Anderson W G Anderson S V Angelova S Antier S Appert K Arai M C Araya J S Areeda M Arène N Arnaud S M Aronson K G Arun S Ascenzi G Ashton S M Aston P Astone F Aubin P Aufmuth K AultONeal C Austin V Avendano A Avila-Alvarez S Babak P Bacon F Badaracco M K M Bader S Bae J Baird P T Baker F Baldaccini G Ballardin S W Ballmer A Bals S Banagiri J C Barayoga C Barbieri S E Barclay B C Barish D Barker K Barkett S Barnum F Barone B Barr L Barsotti M Barsuglia D Barta J Bartlett I Bartos R Bassiri A Basti M Bawaj J C Bayley M Bazzan B Bécsy M Bejger I Belahcene A S Bell D Beniwal M G Benjamin B K Berger G Bergmann S Bernuzzi C P L Berry D Bersanetti A Bertolini J Betzwieser R Bhandare J Bidler E Biggs I A Bilenko S A Bilgili G Billingsley R Birney O Birnholtz S Biscans M Bischi S Biscoveanu A Bisht M Bitossi M A Bizouard J K Blackburn J Blackman C D Blair D G Blair R M Blair S Bloemen F Bobba N Bode M Boer Y Boetzel G Bogaert F Bondu R Bonnand P Booker B A Boom R Bork V Boschi S Bose V Bossilkov J Bosveld Y Bouffanais A Bozzi C Bradaschia P R Brady A Bramley M Branchesi J E Brau M Breschi T Briant J H Briggs F Brighenti A Brillet M Brinkmann P Brockill A F Brooks J Brooks D D Brown S Brunett A Buikema T Bulik H J Bulten A Buonanno D Buskulic C Buy R L Byer M Cabero L Cadonati G Cagnoli C Cahillane J Calderón Bustillo T A Callister E Calloni J B Camp W A Campbell K C Cannon H Cao J Cao G Carapella F Carbognani S Caride M F Carney G Carullo J Casanueva Diaz C Casentini S Caudill M Cavaglià F Cavalier R Cavalieri G Cella P Cerdá-Durán E Cesarini O Chaibi K Chakravarti S J Chamberlin M Chan S Chao P Charlton E A Chase E Chassande-Mottin D Chatterjee M Chaturvedi K Chatziioannou B D Cheeseboro H Y Chen X Chen Y Chen H-P Cheng C K Cheong H Y Chia F Chiadini A Chincarini A Chiummo G Cho H S Cho M Cho N Christensen Q Chu S Chua K W Chung S Chung G Ciani M Cieślar A A Ciobanu R Ciolfi F Cipriano A Cirone F Clara J A Clark P Clearwater F Cleva E Coccia P-F Cohadon D Cohen M Colleoni C G Collette C Collins M Colpi L R Cominsky M Constancio L Conti S J Cooper P Corban T R Corbitt I Cordero-Carrión S Corezzi K R Corley N Cornish D Corre A Corsi S Cortese C A Costa R Cotesta M W Coughlin S B Coughlin J-P Coulon S T Countryman P Couvares P B Covas E E Cowan D M Coward M J Cowart D C Coyne R Coyne J D E Creighton T D Creighton J Cripe M Croquette S G Crowder T J Cullen A Cumming L Cunningham E Cuoco T Dal Canton G Dálya B D'Angelo S L Danilishin S D'Antonio K Danzmann A Dasgupta C F Da Silva Costa L E H Datrier V Dattilo I Dave M Davier D Davis E J Daw D DeBra M Deenadayalan J Degallaix M De Laurentis S Deléglise W Del Pozzo L M DeMarchi N Demos T Dent R De Pietri R De Rosa C De Rossi R DeSalvo O de Varona S Dhurandhar M C Díaz T Dietrich L Di Fiore C DiFronzo C Di Giorgio F Di Giovanni M Di Giovanni T Di Girolamo A Di Lieto B Ding S Di Pace I Di Palma F Di Renzo A K Divakarla A Dmitriev Z Doctor F Donovan K L Dooley S Doravari I Dorrington T P Downes M Drago J C Driggers Z Du J-G Ducoin P Dupej O Durante S E Dwyer P J Easter G Eddolls T B Edo A Effler P Ehrens J Eichholz S S Eikenberry M Eisenmann R A Eisenstein L Errico R C Essick H Estelles D Estevez Z B Etienne T Etzel M Evans T M Evans V Fafone S Fairhurst X Fan S Farinon B Farr W M Farr E J Fauchon-Jones M Favata M Fays M Fazio C Fee J Feicht M M Fejer F Feng A Fernandez-Galiana I Ferrante E C Ferreira T A Ferreira F Fidecaro I Fiori D Fiorucci M Fishbach R P Fisher J M Fishner R Fittipaldi M Fitz-Axen V Fiumara R Flaminio M Fletcher E Floden E Flynn H Fong J A Font P W F Forsyth J-D Fournier Francisco Hernandez Vivanco S Frasca F Frasconi Z Frei A Freise R Frey V Frey P Fritschel V V Frolov G Fronzè P Fulda M Fyffe H A Gabbard B U Gadre S M Gaebel J R Gair L Gammaitoni S G Gaonkar C García-Quirós F Garufi B Gateley S Gaudio G Gaur V Gayathri G Gemme E Genin A Gennai D George J George L Gergely S Ghonge Abhirup Ghosh Archisman Ghosh S Ghosh B Giacomazzo J A Giaime K D Giardina D R Gibson K Gill L Glover J Gniesmer P Godwin E Goetz R Goetz B Goncharov G González J M Gonzalez Castro A Gopakumar S E Gossan M Gosselin R Gouaty B Grace A Grado M Granata A Grant S Gras P Grassia C Gray R Gray G Greco A C Green R Green E M Gretarsson A Grimaldi S J Grimm P Groot H Grote S Grunewald P Gruning G M Guidi H K Gulati Y Guo A Gupta Anchal Gupta P Gupta E K Gustafson R Gustafson L Haegel O Halim B R Hall E D Hall E Z Hamilton G Hammond M Haney M M Hanke J Hanks C Hanna M D Hannam O A Hannuksela T J Hansen J Hanson T Harder T Hardwick K Haris J Harms G M Harry I W Harry R K Hasskew C J Haster K Haughian F J Hayes J Healy A Heidmann M C Heintze H Heitmann F Hellman P Hello G Hemming M Hendry I S Heng J Hennig M Heurs S Hild T Hinderer S Hochheim D Hofman A M Holgado N A Holland K Holt D E Holz P Hopkins C Horst J Hough E J Howell C G Hoy Y Huang M T Hübner E A Huerta D Huet B Hughey V Hui S Husa S H Huttner T Huynh-Dinh B Idzkowski A Iess H Inchauspe C Ingram R Inta G Intini B Irwin H N Isa J-M Isac M Isi B R Iyer T Jacqmin S J Jadhav K Jani N N Janthalur P Jaranowski D Jariwala A C Jenkins J Jiang D S Johnson A W Jones D I Jones J D Jones R Jones R J G Jonker L Ju J Junker C V Kalaghatgi V Kalogera B Kamai S Kandhasamy G Kang J B Kanner S J Kapadia S Karki R Kashyap M Kasprzack S Katsanevas E Katsavounidis W Katzman S Kaufer K Kawabe N V Keerthana F Kéfélian D Keitel R Kennedy J S Key F Y Khalili I Khan S Khan E A Khazanov N Khetan M Khursheed N Kijbunchoo Chunglee Kim J C Kim K Kim W Kim W S Kim Y-M Kim C Kimball P J King M Kinley-Hanlon R Kirchhoff J S Kissel L Kleybolte J H Klika S Klimenko T D Knowles P Koch S M Koehlenbeck G Koekoek S Koley V Kondrashov A Kontos N Koper M Korobko W Z Korth M Kovalam D B Kozak C Krämer V Kringel N Krishnendu A Królak N Krupinski G Kuehn A Kumar P Kumar Rahul Kumar Rakesh Kumar L Kuo A Kutynia S Kwang B D Lackey D Laghi K H Lai T L Lam M Landry B B Lane R N Lang J Lange B Lantz R K Lanza A Lartaux-Vollard P D Lasky M Laxen A Lazzarini C Lazzaro P Leaci S Leavey Y K Lecoeuche C H Lee H K Lee H M Lee H W Lee J Lee K Lee J Lehmann A K Lenon N Leroy N Letendre Y Levin A Li J Li K J L Li T G F Li X Li F Lin F Linde S D Linker T B Littenberg J Liu X Liu M Llorens-Monteagudo R K L Lo L T London A Longo M Lorenzini V Loriette M Lormand G Losurdo J D Lough C O Lousto G Lovelace M E Lower H Lück D Lumaca A P Lundgren R Lynch Y Ma R Macas S Macfoy M MacInnis D M Macleod A Macquet I Magaña Hernandez F Magaña-Sandoval R M Magee E Majorana I Maksimovic A Malik N Man V Mandic V Mangano G L Mansell M Manske M Mantovani M Mapelli F Marchesoni F Marion S Márka Z Márka C Markakis A S Markosyan A Markowitz E Maros A Marquina S Marsat F Martelli I W Martin R M Martin V Martinez D V Martynov H Masalehdan K Mason E Massera A Masserot T J Massinger M Masso-Reid S Mastrogiovanni A Matas F Matichard L Matone N Mavalvala J J McCann R McCarthy D E McClelland P McClincy S McCormick L McCuller S C McGuire C McIsaac J McIver D J McManus T McRae S T McWilliams D Meacher G D Meadors M Mehmet A K Mehta J Meidam E Mejuto Villa A Melatos G Mendell R A Mercer L Mereni K Merfeld E L Merilh M Merzougui S Meshkov C Messenger C Messick F Messina R Metzdorff P M Meyers F Meylahn A Miani H Miao C Michel H Middleton L Milano A L Miller M Millhouse J C Mills M C Milovich-Goff O Minazzoli Y Minenkov A Mishkin C Mishra T Mistry S Mitra V P Mitrofanov G Mitselmakher R Mittleman G Mo D Moffa K Mogushi S R P Mohapatra M Molina-Ruiz M Mondin M Montani C J Moore D Moraru F Morawski G Moreno S Morisaki B Mours C M Mow-Lowry F Muciaccia Arunava Mukherjee D Mukherjee S Mukherjee Subroto Mukherjee N Mukund A Mullavey J Munch E A Muñiz M Muratore P G Murray I Nardecchia L Naticchioni R K Nayak B F Neil J Neilson G Nelemans T J N Nelson M Nery A Neunzert L Nevin K Y Ng S Ng C Nguyen P Nguyen D Nichols S A Nichols S Nissanke F Nocera C North L K Nuttall M Obergaulinger J Oberling B D O'Brien G Oganesyan G H Ogin J J Oh S H Oh F Ohme H Ohta M A Okada M Oliver P Oppermann Richard J Oram B O'Reilly R G Ormiston L F Ortega R O'Shaughnessy S Ossokine D J Ottaway H Overmier B J Owen A E Pace G Pagano M A Page G Pagliaroli A Pai S A Pai J R Palamos O Palashov C Palomba H Pan P K Panda P T H Pang C Pankow F Pannarale B C Pant F Paoletti A Paoli A Parida W Parker D Pascucci A Pasqualetti R Passaquieti D Passuello M Patil B Patricelli E Payne B L Pearlstone T C Pechsiri A J Pedersen M Pedraza R Pedurand A Pele S Penn A Perego C J Perez C Périgois A Perreca J Petermann H P Pfeiffer M Phelps K S Phukon O J Piccinni M Pichot F Piergiovanni V Pierro G Pillant L Pinard I M Pinto M Pirello M Pitkin W Plastino R Poggiani D Y T Pong S Ponrathnam P Popolizio E K Porter J Powell A K Prajapati J Prasad K Prasai R Prasanna G Pratten T Prestegard M Principe G A Prodi L Prokhorov M Punturo P Puppo M Pürrer H Qi V Quetschke P J Quinonez F J Raab G Raaijmakers H Radkins N Radulesco P Raffai S Raja C Rajan B Rajbhandari M Rakhmanov K E Ramirez A Ramos-Buades Javed Rana K Rao P Rapagnani V Raymond M Razzano J Read T Regimbau L Rei S Reid D H Reitze P Rettegno F Ricci C J Richardson J W Richardson P M Ricker G Riemenschneider K Riles M Rizzo N A Robertson F Robinet A Rocchi L Rolland J G Rollins V J Roma M Romanelli R Romano C L Romel J H Romie C A Rose D Rose K Rose D Rosińska S G Rosofsky M P Ross S Rowan A Rüdiger P Ruggi G Rutins K Ryan S Sachdev T Sadecki M Sakellariadou O S Salafia L Salconi M Saleem A Samajdar L Sammut E J Sanchez L E Sanchez N Sanchis-Gual J R Sanders K A Santiago E Santos N Sarin B Sassolas B S Sathyaprakash O Sauter R L Savage P Schale M Scheel J Scheuer P Schmidt R Schnabel R M S Schofield A Schönbeck E Schreiber B W Schulte B F Schutz J Scott S M Scott E Seidel D Sellers A S Sengupta N Sennett D Sentenac V Sequino A Sergeev Y Setyawati D A Shaddock T Shaffer M S Shahriar M B Shaner A Sharma P Sharma P Shawhan H Shen R Shink D H Shoemaker D M Shoemaker K Shukla S ShyamSundar K Siellez M Sieniawska D Sigg L P Singer D Singh N Singh A Singhal A M Sintes S Sitmukhambetov V Skliris B J J Slagmolen T J Slaven-Blair J R Smith R J E Smith S Somala E J Son S Soni B Sorazu F Sorrentino T Souradeep E Sowell A P Spencer M Spera A K Srivastava V Srivastava K Staats C Stachie M Standke D A Steer M Steinke J Steinlechner S Steinlechner D Steinmeyer S P Stevenson D Stocks R Stone D J Stops K A Strain G Stratta S E Strigin A Strunk R Sturani A L Stuver V Sudhir T Z Summerscales L Sun S Sunil A Sur J Suresh P J Sutton B L Swinkels M J Szczepańczyk M Tacca S C Tait C Talbot D B Tanner D Tao M Tápai A Tapia J D Tasson R Taylor R Tenorio L Terkowski M Thomas P Thomas S R Thondapu K A Thorne E Thrane Shubhanshu Tiwari Srishti Tiwari V Tiwari K Toland M Tonelli Z Tornasi A Torres-Forné C I Torrie D Töyrä F Travasso G Traylor M C Tringali A Tripathee A Trovato L Trozzo K W Tsang M Tse R Tso L Tsukada D Tsuna T Tsutsui D Tuyenbayev K Ueno D Ugolini C S Unnikrishnan A L Urban S A Usman H Vahlbruch G Vajente G Valdes M Valentini N van Bakel M van Beuzekom J F J van den Brand C Van Den Broeck D C Vander-Hyde L van der Schaaf J V VanHeijningen A A van Veggel M Vardaro V Varma S Vass M Vasúth A Vecchio G Vedovato J Veitch P J Veitch K Venkateswara G Venugopalan D Verkindt F Vetrano A Viceré A D Viets S Vinciguerra D J Vine J-Y Vinet S Vitale T Vo H Vocca C Vorvick S P Vyatchanin A R Wade L E Wade M Wade R Walet M Walker L Wallace S Walsh H Wang J Z Wang S Wang W H Wang Y F Wang R L Ward Z A Warden J Warner M Was J Watchi B Weaver L-W Wei M Weinert A J Weinstein R Weiss F Wellmann L Wen E K Wessel P Weßels J W Westhouse K Wette J T Whelan B F Whiting C Whittle D M Wilken D Williams A R Williamson J L Willis B Willke W Winkler C C Wipf H Wittel G Woan J Woehler J K Wofford J L Wright D S Wu D M Wysocki S Xiao R Xu H Yamamoto C C Yancey L Yang Y Yang Z Yang M J Yap M Yazback D W Yeeles Hang Yu Haocun Yu S H R Yuen A K Zadrożny A Zadrożny M Zanolin T Zelenova J-P Zendri M Zevin J Zhang L Zhang T Zhang C Zhao G Zhao M Zhou Z Zhou X J Zhu A B Zimmerman M E Zucker J Zweizig S Shandera

Phys Rev Lett 2019 Oct;123(16):161102

The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

We present a search for subsolar mass ultracompact objects in data obtained during Advanced LIGO's second observing run. In contrast to a previous search of Advanced LIGO data from the first observing run, this search includes the effects of component spin on the gravitational waveform. We identify no viable gravitational-wave candidates consistent with subsolar mass ultracompact binaries with at least one component between 0. Read More

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http://dx.doi.org/10.1103/PhysRevLett.123.161102DOI Listing
October 2019
7.512 Impact Factor

Collateral grade of the Willis' circle predicts outcomes of acute intracranial internal carotid artery occlusion before thrombectomy.

Brain Behav 2019 12 7;9(12):e01452. Epub 2019 Nov 7.

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Background And Purpose: Endovascular mechanical thrombectomy (EVMT) shows significant promise in improving acute ischemic stroke (AIS) with proximal artery occlusion, but outcomes have been variable. We explored the patients treated by thrombectomy to investigate the association between a favorable clinical outcome of EVMT in intracranial internal carotid artery occlusion (iICAO) and a set of predictors.

Methods: A total of 38 iICAO patients treated by EVMTs were analyzed. Read More

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http://dx.doi.org/10.1002/brb3.1452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908856PMC
December 2019

Fluid-Structure Interaction Simulation of Blood Flow and Cerebral Aneurysm: Effect of Partly Blocked Vessel.

J Vasc Res 2019 31;56(6):296-307. Epub 2019 Oct 31.

Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.

In this study, using fluid-structure interaction (FSI), 3-dimensional blood flow in an aneurysm in the circle of Willis - which is located in the middle cerebral artery (MCA) - has been simulated. The purpose of this study is to evaluate the effect of a partly blocked vessel on an aneurysm. To achieve this purpose, two cases have been investigated using the FSI method: in the first case, an ideal geometry of aneurysm in the MCA has been simulated; in the second case, modeling is performed for an ideal geometry of the aneurysm in the MCA with a partly blocked vessel. Read More

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http://dx.doi.org/10.1159/000503786DOI Listing
January 2020

Cardiac-Related Pulsatility in the Insula Is Directly Associated With Middle Cerebral Artery Pulsatility Index.

J Magn Reson Imaging 2020 May 30;51(5):1454-1462. Epub 2019 Oct 30.

Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Background: Arterial stiffness in large arteries is a risk factor for cerebral small vessel disease and neurodegeneration. The challenge of accessing intracranial pulsatility noninvasively is one reason few studies provide empirical insight on the relationship between large artery and tissue pulsatility in the human brain.

Purpose: To investigate the association between the functional magnetic resonance imaging (fMRI)-derived cardiac-related pulsatility in the insular cortex and the ultrasound-derived pulsatility index in the middle cerebral artery (MCA-PI). Read More

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http://dx.doi.org/10.1002/jmri.26950DOI Listing
May 2020
3.210 Impact Factor

Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.

J Alzheimers Dis 2019 ;72(3):919-929

Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Background: Alzheimer's disease (AD) has a higher prevalence among African Americans. Targeting cardiovascular and metabolic risk factors may be potential mechanisms to modify AD risk and address racial/ethnic disparities in AD dementia.

Objective: This study investigated relationships among cardiovascular and metabolic risk factors, APOE genotype, AD biomarkers, and intracranial arterial blood flow in Whites and African Americans enriched for AD risk. Read More

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http://dx.doi.org/10.3233/JAD-190645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660PMC
January 2019

Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery.

Birth Defects Res 2019 11 18;111(19):1584-1588. Epub 2019 Oct 18.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Purpose: Turner syndrome (TS) is the most common sex chromosome disorder in women and is associated with a higher than expected death rate secondary to cerebrovascular disease, including stroke. This study evaluates the cerebral vascular anatomy of individuals with TS.

Methods: Twenty-one women with TS had brain magnetic resonance angiography (MRA). Read More

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http://dx.doi.org/10.1002/bdr2.1609DOI Listing
November 2019
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Digital orbitoplethysmograph: A new device to study the regional cerebral circulation using extraorbital plethysmography.

J Neurosci Methods 2020 Jan 12;329:108459. Epub 2019 Oct 12.

Department of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Background: Noninvasive diagnostic methods utilizing pulse wave measurements on the surface of the head are an important tool in diagnosing various types of cerebrovascular disease. The measurement of extraorbital pressure fluctuations reflects intraocular and intracranial pressure changes and can be used to estimate pressure changes in intracranial arteries and the collateral circulation.

New Method: In this paper, we describe our patented (CZ 305757) digital device for noninvasive measuring and monitoring of orbital movements using pressure detection. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.108459DOI Listing
January 2020
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Evaluation of an Artificial Intelligence-Based 3D-Angiography for Visualization of Cerebral Vasculature.

Clin Neuroradiol 2019 Oct 9. Epub 2019 Oct 9.

Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany.

Purpose: The three-dimensional digital subtraction angiography (3D DSA) technique is the current standard and is based on both mask and fill runs to enable the subtraction technique. Artificial intelligence (AI)-based 3D angiography (3DA) was developed to reduce radiation dosage because only one contrast-enhanced run of the C‑arm system is required for reconstruction of DSA-like 3D volumes. The aim was the evaluation of this algorithm regarding its diagnostic information. Read More

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http://dx.doi.org/10.1007/s00062-019-00836-7DOI Listing
October 2019

[Combination of infraoptic anterior cerebral artery with an aneurysm of the ACA-AcomA complex. Case study and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(4):82-89

Burdenko Neurosurgical Center, Moscow, Russia.

The infraoptic anterior cerebral artery (ACA) is an abnormal vessel that usually is a bifurcation of the intradural part of the internal carotid artery (ICA) or near the site of discharge of the ophthalmic artery, which passes under the ipsilateral optic nerve and penetrates between the optic nerves into the prechiasm cistern, reaching the ACA-AcomA complex. The infra-optic ACA is an extremely rare anomaly, but it may be of great clinical significance in surgery of the arteries of the anterior sections of the Willis circle. The article describes the case of a combination of infra-optical ACA with an aneurysm of the ACA-AcomA complex. Read More

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http://dx.doi.org/10.17116/neiro20198304182DOI Listing
November 2019
1 Read