16,018 results match your criteria Ciencia & saude coletiva[Journal]


Isolated teeth from La Ferrassie: Reassessment of the old collections, new remains, and their implications.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Département Homme et environnement, Muséum national d'Histoire naturelle, Musée de l'Homme, UMR 7194 CNRS, Université de Perpignan "Via Domitia", EPCC-CERP de Tautavel, Paris, France.

Objectives: We provide the description and comparative analysis of six new teeth from the site of La Ferrassie. Our goal is to discuss their taxonomic attribution, and to provide an updated inventory of Neandertal and modern human remains from La Ferrassie in their associated archeological context.

Materials And Methods: We use external and internal anatomy, classic morphometrics, and geometric morphometrics. Read More

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http://dx.doi.org/10.1002/ajpa.23798DOI Listing
February 2019

Responses of olive plants exposed to different irrigation treatments in combination with heat shock: physiological and molecular mechanisms during exposure and recovery.

Planta 2019 Feb 15. Epub 2019 Feb 15.

Department of Life Science, Centre for Functional Ecology (CFE), University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

Main Conclusion: A water-deficit period, leading to stomatal control and overexpression of protective proteins (sHSP and DHN), contributes to olive´s tolerance to later imposed stress episodes. Aquaporins modulation is important in olive recovery. Olive is traditionally cultivated in dry farming or in high water demanding irrigated orchards. Read More

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http://dx.doi.org/10.1007/s00425-019-03109-2DOI Listing
February 2019

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the genome, remains largely unexplored. RNA therapeutics is an emerging field that widens the range of druggable targets and includes elements such as microRNA. Read More

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http://dx.doi.org/10.1007/s00018-019-03041-4DOI Listing
February 2019

In Vitro Fecal Fermentation of High Pressure-Treated Fruit Peels Used as Dietary Fiber Sources.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Eugenio Garza Sada 2501, Monterrey, NL 64849, Mexico.

Fruit by-products are being investigated as non-conventional alternative sources of dietary fiber (DF). High hydrostatic pressure (HHP) treatments have been used to modify DF content as well as its technological and physiological functionality. Orange, mango and prickly pear peels untreated (OU, MU and PPU) and HHP-treated at 600 MPa (OP/55 °C and 20 min, MP/22 °C and 10 min, PPP/55 °C and 10 min) were evaluated. Read More

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http://dx.doi.org/10.3390/molecules24040697DOI Listing
February 2019

A Review on (Hydro)Porphyrin-Loaded Polymer Micelles: Interesting and Valuable Platforms for Enhanced Cancer Nanotheranostics.

Pharmaceutics 2019 Feb 15;11(2). Epub 2019 Feb 15.

CQC and Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.

Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents whose full potential can be achieved using nanocarriers. This review provides an overview on nanotheranostic agents based on polymeric micelles and porphyrins developed so far. Read More

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http://dx.doi.org/10.3390/pharmaceutics11020081DOI Listing
February 2019

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Deep Genomics, MaRS Centre, 661 University Ave, Suite 480, Toronto, ON, M5G 1M1, Canada.

Eukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill sensory and motility functions. Their basic structure consists of an axoneme templated by a centriole/basal body. Striking differences in ciliary ultra-structures can be found at the ciliary base, the axoneme and the tip, not only throughout the eukaryotic tree of life, but within a single organism. Read More

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http://dx.doi.org/10.3390/cells8020160DOI Listing
February 2019

On the Person-Place Interaction and Its Relationship with the Responses/Outcomes of Listeners of Urban Soundscape (Compared Cases of Lisbon and Bogotá): Contextual and Semiotic Aspects.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa, Portugal.

Design, planning, and management of the urban soundscape require various interacting fields of knowledge given the fact that it is the human person that experiences and provides meaning to the urban places and their acoustic environments. The process of environmental perception involves contextual information that conditions people's responses and outcomes through the relationship between the variables Person, Activity, and Place. This research focuses on the interaction between Person and Place and its impact on responses and outcomes from listeners with different geographical origin and background. Read More

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http://dx.doi.org/10.3390/ijerph16040551DOI Listing
February 2019

Diversity and Functionality of Culturable Endophytic Bacterial Communities in Chickpea Plants.

Plants (Basel) 2019 Feb 14;8(2). Epub 2019 Feb 14.

ICAAM-Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Universidade de Évora, Pólo da Mitra, Ap. 94, 7002-554 Évora, Portugal.

The aims of this study were to isolate, identify and characterize culturable endophytic bacteria from chickpea ( L.) roots grown in different soils. In addition, the effects of rhizobial inoculation, soil and stress on the functionality of those culturable endophytic bacterial communities were also investigated. Read More

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http://dx.doi.org/10.3390/plants8020042DOI Listing
February 2019

Supramolecular Hybrid Material Based on Engineering Porphyrin Hosts for an Efficient Elimination of Lead(II) from Aquatic Medium.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

QOPNA & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Porphyrins show great promise for future purification demands. This is largely due to their unique features as host binding molecules that can be modified at the synthetic level, and largely improved by their incorporation into inorganic based materials. In this study, we assessed the efficacy of a hybrid material obtained from the immobilization of 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin on silica surface to remove Pb(II), Cu(II), Cd(II), and Zn(II) ions from water. Read More

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http://dx.doi.org/10.3390/molecules24040669DOI Listing
February 2019

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Feb 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing
February 2019

Parasites of Gymnodactylus darwinii Gray, 1845 (Squamata, Phyllodactylidae) from an Atlantic Rainforest fragment.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ecologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Programa de Pós-Graduação em Ciência Animal Tropical, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Laboratório de Parasitologia (LAPAR), Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil. Electronic address:

Gymnodactylus darwinii is an endemic lizard from Atlantic Rainforest. Ecological aspects of your parasitic fauna are still unknown. Therefore, the goal of the present study was to know the composition of parasitic fauna of G. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.010DOI Listing
February 2019

Mandible strength and geometry in relation to bite force: a study in three caviomorph rodents.

J Anat 2019 Feb 15. Epub 2019 Feb 15.

Laboratorio de Morfología Funcional y Comportamiento, Instituto de Investigaciones Marinas y Costeras (IIMyC), Universidad Nacional de Mar del Plata (UNMdP)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mar del Plata, Argentina.

The monophyletic group Caviomorpha constitutes the most diverse rodent clade in terms of locomotion, ecology and diet. Caviomorph species show considerable variation in cranio-mandibular morphology that has been linked to the differences in toughness of dietary items and other behaviors, such as chisel-tooth digging. This work assesses the structural strength of the mandible of three caviomorph species that show remarkable differences in ecology, behavior and bite force: Chinchilla lanigera (a surface-dwelling species), Octodon degus (a semi-fossorial species) and Ctenomys talarum (a subterranean species). Read More

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http://dx.doi.org/10.1111/joa.12946DOI Listing
February 2019

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes.

J Food Sci 2019 Feb 15. Epub 2019 Feb 15.

Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.

Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low-molecular-weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch-to-batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Read More

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http://dx.doi.org/10.1111/1750-3841.14466DOI Listing
February 2019

Unraveling the complex genome of Saccharum spontaneum using Polyploid Gene Assembler.

DNA Res 2019 Feb 14. Epub 2019 Feb 14.

Laboratório de Genômica e bioEnergia (LGE), Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.

The Polyploid Gene Assembler (PGA), developed and tested in this study, represents a new strategy to perform gene-space assembly from complex genomes using low coverage DNA sequencing. The pipeline integrates reference-assisted loci and de novo assembly strategies to construct high-quality sequences focused on gene content. Pipeline validation was conducted with wheat (Triticum aestivum), a hexaploid species, using barley (Hordeum vulgare) as reference, that resulted in the identification of more than 90% of genes and several new genes. Read More

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http://dx.doi.org/10.1093/dnares/dsz001DOI Listing
February 2019

Impact of a sustained consumption of grape extract on digestion, gut microbial metabolism and intestinal barrier in broiler chickens.

Food Funct 2019 Feb 15. Epub 2019 Feb 15.

Facultad de Veterinaria, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.

The effect of dietary supplementation with grape extract (GE) at 2.5 and 5.0 g kg-1 of feed on intestinal utilization of polyphenols and gut health of broiler chickens was determined. Read More

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http://dx.doi.org/10.1039/c8fo02465kDOI Listing
February 2019

Burden of paraquat poisoning in the department of Antioquia, Colombia.

BMC Pharmacol Toxicol 2019 Feb 15;20(1):11. Epub 2019 Feb 15.

Grupo de Investigación en farmacología y toxicología, Centro de Información y Estudio de Medicamentos y Tóxicos (CIEMTO), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Background: Paraquat (PQ) poisoning is a public health problem in many regions of Colombia. This study aimed to estimate the burden of PQ poisoning in the Department of Antioquia, Colombia.

Methods: Disability-adjusted life year (DALYs) were calculated as the sum of years of life lost (YLL) and years of life lived with disability (YLD) due to paraquat poisoning in Antioquia; a bootstrapped method with 1000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. Read More

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http://dx.doi.org/10.1186/s40360-019-0291-0DOI Listing
February 2019

, , and Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity.

Evid Based Complement Alternat Med 2019 15;2019:2421695. Epub 2019 Jan 15.

Mestrado em Ciência Animal, Universidade Estadual do Maranhão, 65055-310 São Luís, MA, Brazil.

The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of , , and essential oils. Read More

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http://dx.doi.org/10.1155/2019/2421695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350612PMC
January 2019

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders.

Front Endocrinol (Lausanne) 2018 31;9:778. Epub 2019 Jan 31.

Dentistry Faculty, Institute in Dentistry Sciences, University of Chile, Santiago, Chile.

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. Read More

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http://dx.doi.org/10.3389/fendo.2018.00778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365421PMC
January 2019

Unexpected population fragmentation in an endangered seabird: the case of the Peruvian diving-petrel.

Sci Rep 2019 Feb 14;9(1):2021. Epub 2019 Feb 14.

Millennium Nucleus for Ecology and Sustainable Management of Oceanic Island (ESMOI), Departamento de Biología Marina, Facultad de Ciencias del Mar, Universidad Católica del Norte, Larrondo 1281, Coquimbo, Chile.

In less than one century, the once-abundant Peruvian diving petrel has become the first endangered seabird of the Humboldt Current System (HCS). This small endemic petrel of the South American Pacific coast is now an important indicator of ongoing habitat loss and of the success of local conservation policies in the HCS - an ecoregion designated as a priority for the conservation of global biodiversity. Yet so far, poorly understood life history traits such as philopatry or dispersal ability may strongly influence the species' response to ecosystem changes, but also our capacity to assess and interpret this response. Read More

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http://dx.doi.org/10.1038/s41598-019-38682-9DOI Listing
February 2019

Juvenile hormone controls ovarian development in female Anopheles albimanus mosquitoes.

Sci Rep 2019 Feb 14;9(1):2127. Epub 2019 Feb 14.

Department of Biological Sciences and Biomolecular Science Institute, Florida International University, Miami, FL, USA.

Anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. Despite their medical importance, laboratory studies on key aspects of Anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (JH) in the control of female reproduction. The study presented here attempts to fill a gap of knowledge in our understanding of the JH control of ovarian development in female Anophelinae mosquitoes, using Anopheles albimanus as a model. Read More

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http://dx.doi.org/10.1038/s41598-019-38631-6DOI Listing
February 2019

Five genomic regions have a major impact on fat composition in Iberian pigs.

Sci Rep 2019 Feb 14;9(1):2031. Epub 2019 Feb 14.

Institute for Animal Science and Technology, Universitat Politècnica de València, 46022, Valencia, Spain.

The adipogenic nature of the Iberian pig defines many quality attributes of its fresh meat and dry-cured products. The distinct varieties of Iberian pig exhibit great variability in the genetic parameters for fat deposition and composition in muscle. The aim of this work is to identify common and distinct genomic regions related to fatty acid composition in Retinto, Torbiscal, and Entrepelado Iberian varieties and their reciprocal crosses through a diallelic experiment. Read More

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http://dx.doi.org/10.1038/s41598-019-38622-7DOI Listing
February 2019

Immunosensor for the Diagnostics of Autoimmune Hemolytic Anemia (AIHA) Based on Immobilization of a Monoclonal Antibody on a Layer of Silk Fibroin.

J Nanosci Nanotechnol 2019 Jul;19(7):3772-3776

Universidade Estadual Paulista, Instituto de Química, Araraquara, SP 14800-060, Brazil.

The diagnostics of the autoimmune hemolytic anemia (AIHA), a rare disease caused by autoantibody-induced hemolysis, is still prone to false positives for it is based on visual observation in the so-called Direct Coombs test. In this study, we developed a specific IgG hemolysis immunosensor produced with layer-by-layer (LbL) films containing a monoclonal antibody against human immunoglobulin (mAbIMUG) deposited along with a layer of silk fibroin (SF) derived from cocoons. Adsorption of mAbIMUG on a SF layer was confirmed by the fluorescence emission band at 326 nm. Read More

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http://dx.doi.org/10.1166/jnn.2019.16305DOI Listing

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), and Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, Elche, E-03202 Alicante, Spain.

Cation binding under equilibrium conditions has been used as a tool to explore the accessibility of permeant and nonpermeant cations to the selectivity filter in three different inactivated models of the potassium channel KcsA. The results show that the stack of ion binding sites (S1 to S4) in the inactivated filter models remain accessible to cations as they are in the resting channel state. The inactivated state of the selectivity filter is therefore "resting-like" under such equilibrium conditions. Read More

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http://dx.doi.org/10.3390/ijms20030689DOI Listing
February 2019

Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos.

Medicina (Kaunas) 2019 Feb 5;55(2). Epub 2019 Feb 5.

Laboratorio de Medicina Genómica, Hospital Regional Lic. Adolfo López Mateos ISSSTE, Mexico City 01030, Mexico.

Type 2 diabetes (T2D) is a major problem of public health in Mexico. We investigated the influence of five polymorphisms, previously associated with obesity and cardiovascular disease in Europeans and Asians, on T2D in Mexican Mestizos. A total of 1358 subjects from 30 to 85 years old were genotyped for five loci: rs501120; rs1333049; rs2259816; rs9939609; and rs7799039. Read More

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http://dx.doi.org/10.3390/medicina55020040DOI Listing
February 2019

The Membrane Proximal Domain of TRPV1 and TRPV2 Channels Mediates Protein⁻Protein Interactions and Lipid Binding In Vitro.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Catalonia, Spain.

Constitutive or regulated membrane protein trafficking is a key cell biology process. Transient receptor potential channels are somatosensory proteins in charge of detecting several physical and chemical stimuli, thus requiring fine vesicular trafficking. The membrane proximal or pre-S1 domain (MPD) is a highly conserved domain in transient receptor potential channels from the vanilloid (TRPV) subfamily. Read More

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http://dx.doi.org/10.3390/ijms20030682DOI Listing
February 2019

The influence of anthropogenic organic matter and nutrient inputs on the food web structure in a coastal lagoon receiving agriculture and shrimp farming effluents.

Sci Total Environ 2019 Jan 28;664:635-646. Epub 2019 Jan 28.

Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación de Ciencia de los Alimentos, Unidad Hermosillo, Carretera Gustavo Enrique Astiazarán Rosas 46, Colonia La Victoria, Hermosillo 83304, Sonora, Mexico. Electronic address:

In this study, we elucidated the impacts of allochthonous organic matter (OM) and nutrients (N and P) inputs coming from agriculture and shrimp aquaculture activities on food web structure in a subtropical coastal lagoon located on the central-east of the Gulf of California. This coastal lagoon is highly influenced by OM and nutrients inputs by a large agriculture district and aquaculture development center in Mexico. We also selected a second coastal lagoon, without direct OM and nutrients inputs, considered as a 'pristine' ecosystem. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.343DOI Listing
January 2019

Bioinformatics calls the school: Use of smartphones to introduce Python for bioinformatics in high schools.

PLoS Comput Biol 2019 Feb 14;15(2):e1006473. Epub 2019 Feb 14.

Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires, Argentina.

The dynamic nature of technological developments invites us to rethink the learning spaces. In this context, science education can be enriched by the contribution of new computational resources, making the educational process more up-to-date, challenging, and attractive. Bioinformatics is a key interdisciplinary field, contributing to the understanding of biological processes that is often underrated in secondary schools. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006473DOI Listing
February 2019

Geographic and Temporal Variation of Distinct Intracellular Endosymbiont Strains of Wolbachia sp. in the Grasshopper Chorthippus parallelus: a Frequency-Dependent Mechanism?

Microb Ecol 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Biología (Genética), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.

Wolbachia is an intracellular endosymbiont that can produce a range of effects on host fitness, but the temporal dynamics of Wolbachia strains have rarely been experimentally evaluated. We compare interannual strain frequencies along a geographical region for understanding the forces that shape Wolbachia strain frequency in natural populations of its host, Chorthippus parallelus (Orthoptera, Acrididae). General linear models show that strain frequency changes significantly across geographical and temporal scales. Read More

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http://link.springer.com/10.1007/s00248-019-01338-2
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http://dx.doi.org/10.1007/s00248-019-01338-2DOI Listing
February 2019
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Natural antimicrobials for control of Salmonella Enteritidis in feed and in vitro model of the chicken digestive process.

J Anim Physiol Anim Nutr (Berl) 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-graduação em Ciência Animal, Pontifícia Universidade Católica do Paraná, PUCPR, Curitiba, Brazil.

This study evaluated the antimicrobial effect of essential oils (EO) and organic acids (OA) against Salmonella Enteritidis in chicken feed and during an in vitro model that mimics the chicken digestive process. The minimal inhibitory concentration (MIC) of allyl isothiocyanate (AITC), carvacrol (CV), propionic acid (PROP) and caproic acid (CAP) were individually determined. Then, based on the MICs of each compound, combinations of EOs and/or OAs were tested to evaluate their synergic antimicrobial effect. Read More

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http://dx.doi.org/10.1111/jpn.13070DOI Listing
February 2019

Influence of Acacia dealbata Link bark extracts on the growth of Allium cepa L. plants under high salinity conditions.

J Sci Food Agric 2019 Feb 13. Epub 2019 Feb 13.

Centre for Functional Ecology - Science for People & the Planet (CFE), Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

Background: Acacia dealbata Link is an invasive plant worldwide. Finding potential uses for its waste that contribute to control its spread and revert in benefits for agriculture has recently become a new research topic. This study aimed at evaluating the potential biostimulant effect of the bark extract derived from the management of A. Read More

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http://doi.wiley.com/10.1002/jsfa.9637
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http://dx.doi.org/10.1002/jsfa.9637DOI Listing
February 2019
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Ecological Strategies Behind the Selection of Cultivable Actinomycete Strains from the Yucatan Peninsula for the Discovery of Secondary Metabolites with Antibiotic Activity.

Microb Ecol 2019 Feb 14. Epub 2019 Feb 14.

Laboratorio de Ecología Microbiana y Productos Naturales Marinos, Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México, Sisal, Yucatán, Mexico.

The quest for novel natural products has recently focused on the marine environment as a source for novel microorganisms. Although isolation of marine-derived actinomycete strains is now common, understanding their distribution in the oceans and their adaptation to this environment can be helpful in the selection of isolates for further novel secondary metabolite discovery. This study explores the taxonomic diversity of marine-derived actinomycetes from distinct environments in the coastal areas of the Yucatan Peninsula and their adaptation to the marine environment as a first step towards novel natural product discovery. Read More

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http://dx.doi.org/10.1007/s00248-019-01329-3DOI Listing
February 2019

BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Front Oncol 2019 29;9:16. Epub 2019 Jan 29.

Hematology and Transfusion Medicine Center, Instituto Nacional de Ciência e Tecnologia do Sangue, University of Campinas, Hemocentro-Unicamp, São Paulo, Brazil.

Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells present genetic and epigenetic abnormalities and, due to the heterogeneity of these molecular alterations, the current treatment options remain unsatisfactory. Hypomethylating agents (HMA), especially azacitidine, are the mainstay of treatment for high-risk MDS patients and HMA are used in treating elderly AML. Read More

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http://dx.doi.org/10.3389/fonc.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361844PMC
January 2019

Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis.

Front Immunol 2018 29;9:3100. Epub 2019 Jan 29.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Cerebral malaria (CM) is a life-threatening neurological syndrome caused by infection afflicting mainly children in Africa. Current pathogenesis models implicate parasite and host-derived factors in impairing brain vascular endothelium (BVE) integrity. Sequestration of -infected red blood cells (iRBCs) in brain microvessels is a hallmark of CM pathology. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361776PMC
January 2019

Domestication of Local Microbial Consortia for Efficient Recovery of Gold Through Top-Down Selection in Airlift Bioreactors.

Front Microbiol 2019 30;10:60. Epub 2019 Jan 30.

Microbial Ecophysiology Laboratory, Fundación Ciencia & Vida, Santiago, Chile.

Extreme acidophiles play central roles in the geochemical cycling of diverse elements in low pH environments. This has been harnessed in biotechnologies such as biomining, where microorganisms facilitate the recovery of economically important metals such as gold. By generating both extreme acidity and a chemical oxidant (ferric iron) many species of prokaryotes that thrive in low pH environments not only catalyze mineral dissolution but also trigger both community and individual level adaptive changes. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363673PMC
January 2019

Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida.

Nat Commun 2019 Feb 13;10(1):737. Epub 2019 Feb 13.

Max-Planck Institute for Molecular Plant Physiology, Am Muehlenberg 1, 14476, Potsdam, Germany.

Plants have adapted to the diurnal light-dark cycle by establishing elaborate transcriptional programs that coordinate many metabolic, physiological, and developmental responses to the external environment. These transcriptional programs have been studied in only a few species, and their function and conservation across algae and plants is currently unknown. We performed a comparative transcriptome analysis of the diurnal cycle of nine members of Archaeplastida, and we observed that, despite large phylogenetic distances and dramatic differences in morphology and lifestyle, diurnal transcriptional programs of these organisms are similar. Read More

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http://dx.doi.org/10.1038/s41467-019-08703-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374488PMC
February 2019

KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.

Nat Commun 2019 Feb 13;10(1):735. Epub 2019 Feb 13.

Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Lota 2465, 7510157, Santiago, Chile.

Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Read More

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http://dx.doi.org/10.1038/s41467-019-08501-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374470PMC
February 2019

Evaluation of lifestyle of female adolescents through latent class analysis approach.

BMC Public Health 2019 Feb 13;19(1):184. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciência da Nutrição, Viçosa, Brasil.

Background: Lack of regular physical activity, high sedentary behavior and presence of unbalanced alimentary practices are attitudes associated with an inadequate lifestyle among female adolescents.

Objective: to assess the lifestyle of female adolescents based on measurements of behavioral variables.

Methods: Cross-sectional study with 405 female adolescents between 14 and 19 years old, resident and attending public schools in Viçosa (state of Minas Gerais). Read More

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http://dx.doi.org/10.1186/s12889-019-6488-8DOI Listing
February 2019

Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in S2 Cells.

Biomolecules 2019 Feb 12;9(2). Epub 2019 Feb 12.

Epithelial Polarity and Cell Division, i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

Schneider 2 (S2) cells are a simple and powerful system commonly used in cell biology because they are well suited for high resolution microscopy and RNAi-mediated depletion. However, understanding dynamic processes, such as cell division, also requires methodology to interfere with protein function with high spatiotemporal control. In this research study, we report the adaptation of an optogenetic tool to S2 cells. Read More

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http://dx.doi.org/10.3390/biom9020061DOI Listing
February 2019

Improved Morphine-Loaded Hydrogels for Wound-Related Pain Relief.

Pharmaceutics 2019 Feb 12;11(2). Epub 2019 Feb 12.

Research Medicine Research Institute (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.

The use of morphine applied topically to painful wounds has potential advantages, such as dose reduction, fewer side effects and compound formulations, have been proposed for this purpose. Given the potential high impact of drug product quality on a patient's health, the aim of the present study was to develop two stable sterile hydrogels containing morphine hydrochloride, intended for topical application on painful wounds. Two carboxymethylcellulose sodium-based hydrogels were prepared containing 0. Read More

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http://www.mdpi.com/1999-4923/11/2/76
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http://dx.doi.org/10.3390/pharmaceutics11020076DOI Listing
February 2019
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Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.

Mar Drugs 2019 Feb 12;17(2). Epub 2019 Feb 12.

Departamento de Biología Funcional, Área de Microbiología, e Instituto Universitario de Oncología del Principado de Asturias. Universidad de Oviedo, 33006 Oviedo, Spain.

The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete MSM3, isolated from samples of the intertidal seaweed sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Read More

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http://dx.doi.org/10.3390/md17020114DOI Listing
February 2019

A Multi-Bioassay Integrated Approach to Assess the Antifouling Potential of the Cyanobacterial Metabolites Portoamides.

Mar Drugs 2019 Feb 12;17(2). Epub 2019 Feb 12.

Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.

The cyclic peptides portoamides produced by the cyanobacterium sp. LEGE 05292 were previously isolated and their ability to condition microcommunities by allelopathic effect was described. These interesting bioactive properties are, however, still underexplored as their biotechnological applications may be vast. Read More

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http://dx.doi.org/10.3390/md17020111DOI Listing
February 2019

HH103 RirA Is Required for Oxidative Stress Resistance and Efficient Symbiosis with Soybean.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Departamento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC, c/ Profesor Albareda 1, 18008 Granada, Spain.

Members of contain a homologue of the iron-responsive regulatory protein RirA. In different bacteria, RirA acts as a repressor of iron uptake systems under iron-replete conditions and contributes to ameliorate cell damage during oxidative stress. In and , mutations in do not impair symbiotic nitrogen fixation. Read More

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http://dx.doi.org/10.3390/ijms20030787DOI Listing
February 2019

The Metallome of Lung Cancer and its Potential Use as Biomarker.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, Research Center on Health and Environment (RENSMA), 21007 Huelva, Spain.

Carcinogenesis is a very complex process in which metals have been found to be critically involved. In this sense, a disturbed redox status and metal dyshomeostasis take place during the onset and progression of cancer, and it is well-known that trace elements participate in the activation or inhibition of enzymatic reactions and metalloproteins, in which they usually participate as cofactors. Until now, the role of metals in cancer have been studied as an effect, establishing that cancer onset and progression affects the disturbance of the natural chemical form of the essential elements in the metabolism. Read More

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http://dx.doi.org/10.3390/ijms20030778DOI Listing
February 2019

First Report of Grapevine Syrah virus-1 in Chilean Grapevines.

Plant Dis 2010 May;94(5):633

Fundación Ciencia para la Vida and MIFAB, Zañartu 1482, Universidad Andrés Bello, Facultad de Ciencias Biológicas, República 217, Santiago, Chile.

At least 58 viruses have been reported to infect grapevines, causing economic damage globally. Our lab has reported previously the presence of more than 10 viral species in Chilean grapevines (2,3). Grapevine Syrah virus-1 (GSyV-1) is a novel marafivirus recently described in California vineyards (1). Read More

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http://dx.doi.org/10.1094/PDIS-94-5-0633ADOI Listing

Classification of the inoculant strain of cowpea UFLA03-84 and of other strains from soils of the Amazon region as Bradyrhizobium viridifuturi (symbiovar tropici).

Braz J Microbiol 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Ciência do Solo, Universidade Federal de Lavras, Lavras, MG, 37200-000, Brazil.

Cowpea (Vigna unguiculata L.) is a legume species that considerably benefits from inoculation with nitrogen fixing bacteria of the genus Bradyrhizobium. One of the strains recommended for inoculation in cowpea in Brazil is UFLA03-84 (Bradyrhizobium sp. Read More

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http://dx.doi.org/10.1007/s42770-019-00045-xDOI Listing
February 2019

Effect of essential oil from Ageratum fastigiatum on beta-integrin (CD18) expression on human lymphocytes stimulated with phorbol myristate acetate in vitro.

Nat Prod Res 2019 Feb 13:1-5. Epub 2019 Feb 13.

b Instituto de Ciência e Tecnologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri , Diamantina , Brasil.

Agareratum fastigiatum is a Brazilian medicinal plant used as anti-inflammaroty and for wound healing by the folk medicine. In vitro and in vivo studies involving A. fastigiatum essential oil (EOAF) showed indications of anti-inflammatory activity, however, its effect on membrane integrins involved on cell migration is still unclear. Read More

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http://dx.doi.org/10.1080/14786419.2019.1569653DOI Listing
February 2019

The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection.

Virus Genes 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.

The respiratory syncytial virus (RSV) is the main pathogen associated with upper respiratory tract infections during early childhood. Vertical transmission of this virus has been suggested in humans, based on observations recorded during animal studies that revealed an association of RSV with persistent structural and functional changes in the developing lungs of the offspring. However, human placentas have not yet been evaluated for susceptibility to RSV infection. Read More

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http://dx.doi.org/10.1007/s11262-019-01646-2DOI Listing
February 2019

Electronic structure and reactivity of Fe(iv)oxo species in metal-organic frameworks.

Phys Chem Chem Phys 2019 Feb 13. Epub 2019 Feb 13.

Center for Research Computing, University of Pittsburgh, 312 Schenley Place, 4420 Bayard Street, Pittsburgh, PA 15260, USA.

We investigate the potential use of Fe(iv)oxo species supported on a metal-organic framework in the catalytic hydroxylation of methane to produce methanol. We use periodic density-functional theory calculations at the 6-31G**/B3LYP level of theory to study the electronic structure and chemical reactivity in the hydrogen abstraction reaction from methane in the presence of Fe(iv)O(oxo) supported on MOF-74. Our results indicate that the Fe(iv)O moiety in MOF-74 is characterised by a highly reactive (quintet) ground-state, with a distance between Fe(iv) and O(oxo) of 1. Read More

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http://dx.doi.org/10.1039/c8cp07580hDOI Listing
February 2019

Water adsorption, dissociation and oxidation on SrTiO and ferroelectric surfaces revealed by ambient pressure X-ray photoelectron spectroscopy.

Phys Chem Chem Phys 2019 Feb 13. Epub 2019 Feb 13.

Institut de Ciència de Materials de Barcelona ICMAB-CSIC, Campus de la UAB, E-08193 Bellaterra, Spain.

Water dissociation on oxides is of great interest because its fundamental aspects are still not well understood and it has implications in many processes, from ferroelectric polarization screening phenomena to surface catalysis and surface chemistry on oxides. In situ water dissociation and redox processes on metal oxide perovskites which easily expose TiO2-terminated surfaces, such as SrTiO3, BaTiO3 or Pb(Zr,Ti)O3, are studied by ambient pressure XPS, as a function of water vapour pressure. From the analysis of the O1s spectrum, we determine the presence of different types of oxygen based species, from hydroxyl groups, either bound to Ti4+ and metal sites or lattice oxygen, to different peroxide compounds, and propose a model for the adsorbate layer composition, valid for environmental conditions. Read More

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http://dx.doi.org/10.1039/c8cp07632dDOI Listing
February 2019