1,726 results match your criteria Cicatricial Pemphigoid


Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency.

Ocul Surf 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Japan; Cornea Center Eye Bank, Tokyo Dental College, Ichikawa General Hospital, Japan; Department of Ophthalmology, Keio University School of Medicine, Japan.

Purpose: This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation (CCST), and to clarify risk factors that affected the outcomes.

Methods: We retrospectively analyzed the medical charts and photographs of 246 consecutive surgeries (162 eyes from 139 patients) that used CCST for treating total limbal stem cell deficiency. Deficiency types included Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN; n = 80), ocular surface burns (Burn; n = 75), ocular cicatricial pemphigoid (OCP) or pseudo-OCP (n = 58), and others (n = 33). Read More

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http://dx.doi.org/10.1016/j.jtos.2020.06.005DOI Listing

Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

University of Michigan Medical School, Ann Arbor, Michigan.

Purpose: Conjunctival cicatrizing conditions are vision threatening, with poor outcomes despite aggressive systemic therapy. This study tests the utility of serial injections of 5-fluorouracil (5-FU) into the fornices to treat conjunctival scarring in patients with ocular cicatricial pemphigoid or Stevens-Johnson syndrome/toxic epidermal necrolysis.

Methods: Retrospective cohort study. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001717DOI Listing

Characteristics Upon Presentation of Ocular Mucous Membrane Pemphigoid Patients in Puerto Rico.

P R Health Sci J 2020 03;39(1):34-38

Department of Ophthalmology, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: To describe the characteristics upon presentation of a cohort of Hispanic patients living in Puerto Rico with ocular mucous membrane pemphigoid (MMP).

Methods: Retrospective chart review of subjects with ocular MMP at one academic institution and one private practice. Patients with clinical evidence of ocular MMP, along with a positive mucous membrane biopsy revealing linear antibody or C3 deposition in the basement membrane zone, or with a positive indirect immunofluorescence assay were included. Read More

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Ocular cicatricial pemphigoid treated with intramuscular corticotropin injections.

JAAD Case Rep 2020 May 30;6(5):450-452. Epub 2020 Apr 30.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200478PMC

[Ocular Cicatricial Pemphigoid - a Case Report].

Klin Monbl Augenheilkd 2020 04 24;237(4):414-416. Epub 2020 Apr 24.

Augenklinik, Universitätsspital Basel, Schweiz.

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http://dx.doi.org/10.1055/a-1068-2672DOI Listing

Cicatricial pemphigoid presenting as desquamative gingivitis.

J Dent Sci 2020 Mar 23;15(1):110-111. Epub 2019 Dec 23.

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

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http://dx.doi.org/10.1016/j.jds.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109484PMC

[Osteo-odonto-keratoprosthesis: a tooth to regain sight].

Rev Med Liege 2020 Mar;75(3):164-170

Service de Chirurgie plastique et maxillo-faciale, CHU Liège, Belgique.

As the leading cause of blindness in the world, corneal diseases are second only to cataracts. However, the epidemiology of corneal disease is complex and includes a wide variety of infectious and inflammatory eye diseases (trachoma), immune sequelae (cicatricial pemphigoid on Lyell's disease) of after trauma (chemical burn). The general treatment for severe corneal disease is the corneal transplantation with penetrating keratoplasty. Read More

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Clinical Outcomes From Cultivated Allogenic Stem Cells vs. Oral Mucosa Epithelial Transplants in Total Bilateral Stem Cells Deficiency.

Front Med (Lausanne) 2020 18;7:43. Epub 2020 Feb 18.

Department of Ophthalmology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Total bilateral limbal stem cell deficiency results from various pathologies, from burns (either chemical or physical) to Sjogren Syndrome, aniridia or ocular cicatricial pemphigoid. After the loss of stem cells, normal corneal epithelium is replaced by a more opaque and vascularized conjunctival epithelium, causing loss of vision. After 1997, cultivation techniques for limbal stem cells became possible. Read More

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http://dx.doi.org/10.3389/fmed.2020.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040221PMC
February 2020

Reliability of Conjunctival Biopsy for Diagnosis of Ocular Mucous Membrane Pemphigoid: Redetermination of the Standard for Diagnosis and Outcomes of Previously Biopsy-Negative Patients.

Ocul Immunol Inflamm 2020 Mar 4:1-8. Epub 2020 Mar 4.

Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, USA.

: To demonstrate the reliability of conjunctival biopsy analyzed by direct immunofluorescence (DIF) and supplemented with avidin-biotin complex immunoperoxidase (ABC) in diagnosing oMMP, and report therapy response in biopsy-positive patients, particularly when previously biopsy-negative elsewhere.: Retrospective outcomes review of 136 consecutive patients after conjunctival biopsy for suspected oMMP.: Among 136 patients, 66% were diagnosed with oMMP by DIF and 13% via supplemental ABC immunoperoxidase. Read More

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http://dx.doi.org/10.1080/09273948.2020.1716988DOI Listing

Bilateral keratoprostheses in a patient with ocular mucous membrane pemphigoid.

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Mucous membrane pemphigoid (MMP) with ocular involvement, also referred to as ocular cicatricial pemphigoid, is a rare, autoimmune blistering disease that can have devastating effects for patients. The resulting corneal neovascularization, recurrent corneal abrasions, and ulceration can ultimately result in severe vision loss. We present a 64-year-old man with recalcitrant ocular MMP and consequently advanced corneal involvement that received bilateral keratoprostheses. Read More

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November 2019

Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface.

Sci Rep 2020 Feb 10;10(1):2216. Epub 2020 Feb 10.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States.

A growing body of evidence implicates endoplasmic reticulum (ER) stress in the pathogenesis of chronic inflammatory and autoimmune disorders. Here, we demonstrate that the proinflammatory cytokine TNFα stimulates matrix metalloproteinase 9 (MMP9) at the ocular surface through a c-Fos-dependent mechanism of ER stress. We found positive reactivity of the molecular chaperone BiP/GRP78 in conjunctival epithelium of patients with ocular cicatricial pemphigoid and increased levels of BiP/GRP78, sXBP1 and GRP94 in human corneal epithelial cells treated with TNFα. Read More

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http://dx.doi.org/10.1038/s41598-020-59237-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010695PMC
February 2020

A Rare Case of Plasma Cell Gingivitis with Cheilitis.

Case Rep Dent 2019 16;2019:2939126. Epub 2019 Dec 16.

Department of Periodontology, Govt. College of Dentistry, Indore, M.P., India.

Background: Plasma cell gingivitis (PCG) is a rare condition of the gingiva, characterized histopathologically by infiltration of plasma cells in connective tissue. Hypersensitivity reaction due to antigen is considered as primary etiological factor.

Case Presentation: The present case is of an 18-year-old male patient suffering from gingival enlargement along with cheilitis. Read More

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http://dx.doi.org/10.1155/2019/2939126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942776PMC
December 2019

Oesophagitis Dissecans Superficialis as the Presenting Sign of Isolated Oesophageal Mucous Membrane Pemphigoid.

J Gastrointestin Liver Dis 2019 Dec 9;28(4):380. Epub 2019 Dec 9.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; Department of Physiopathology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.15403/jgld-204DOI Listing
December 2019

Mucocutaneous Diseases.

Dent Clin North Am 2020 01 21;64(1):139-162. Epub 2019 Oct 21.

Division of Oral Pathology, Department of Diagnostic Sciences, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA.

Mucocutaneous diseases affecting the oral cavity are predominantly immune mediated or inflammatory. Three of the most common and clinically significant conditions are reviewed in this article: lichen planus, pemphigus vulgaris, and mucous membrane pemphigoid. Because oral manifestations may be the first or only manifestation of mucocutaneous diseases, oral health professionals play a critical role in the early diagnosis and multidisciplinary management of these conditions. Read More

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http://dx.doi.org/10.1016/j.cden.2019.08.009DOI Listing
January 2020

Brunsting-Perry Pemphigoid as Differential Diagnosis of Nonmelanoma Skin Cancer.

Authors:
Gerhard Eichhoff

Cureus 2019 Aug 16;11(8):e5400. Epub 2019 Aug 16.

Dermatology Service, Wellington Regional Hospital, Wellington, NZL.

Brunsting-Perry pemphigoid is a rare autoimmune blistering skin disease. Similar to nonmelanoma skin cancers, Brunsting-Perry pemphigoid has a predilection for the head and neck. Herein, a case of solitary Brunsting-Perry pemphigoid treated as cutaneous squamous cell carcinoma (SCC) with subsequent excision is reported. Read More

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http://dx.doi.org/10.7759/cureus.5400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793596PMC
August 2019
1 Read

A Retrospective Study of Patient-Reported Data of Bullous Pemphigoid and Mucous Membrane Pemphigoid From a US-Based Registry.

Front Immunol 2019 20;10:2219. Epub 2019 Sep 20.

Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare chronic autoimmune disorders characterized by subepidermal blistering. For the United States, there is a limited amount of studies in BP and MMP that address disease demographics and clinical data. In order to more comprehensively examine disease demographics and clinical factors, we performed a retrospective analysis of patient-reported data of 138 BP and 165 MMP patients enrolled in the International Pemphigus & Pemphigoid Foundation (IPPF) disease registry from 2010-2016. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768115PMC
September 2019
1 Read

Nivolumab-related mucous membrane pemphigoid.

Eur J Cancer 2019 Nov 3;121:172-176. Epub 2019 Oct 3.

Oncodermatology Department, Institut Claudius REGAUD and Institut Universitaire du Cancer Toulouse Oncopole, 1 Avenue Irène Joliot-Curie 31059, Toulouse Cedex 9, France.

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http://dx.doi.org/10.1016/j.ejca.2019.08.030DOI Listing
November 2019

An Unusual Web Stricture in the Cervical Esophagus.

Gastroenterology 2020 01 26;158(1):54-55. Epub 2019 Sep 26.

Department of Gastroenterology and Hepatology, Mie University Hospital, Tsu, Japan.

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http://dx.doi.org/10.1053/j.gastro.2019.08.050DOI Listing
January 2020
1 Read

Characterization of Progressive Cicatrizing Conjunctivitis With Negative Immunofluorescence Staining.

Am J Ophthalmol 2020 01 25;209:3-9. Epub 2019 Sep 25.

Ocular Surface Diseases and Dry Eye Clinic, Division of Cornea and External Diseases, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

Purpose: To characterize the clinical features of patients with direct immunofluorescence (DIF)-negative mucous membrane pemphigoid (MMP).

Design: Retrospective case series.

Methods: Thirty-six patients who underwent a conjunctival biopsy for suspected MMP were included. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.09.020DOI Listing
January 2020

Detachment of keratinocytes at the basement membrane zone caused by inhibitory effect of the antibodies from sera of mucous membrane pemphigoid patients.

J Dermatol 2019 Nov 12;46(11):1046-1048. Epub 2019 Sep 12.

Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1111/1346-8138.15083DOI Listing
November 2019

Noncandidal vaginitis: a comprehensive approach to diagnosis and management.

Am J Obstet Gynecol 2020 02 9;222(2):114-122. Epub 2019 Sep 9.

Indiana University School of Medicine, Indianapolis, IN.

Vaginitis is one of the most common causes of patient visits to gynecologists, primary care providers, and urgent care centers. However, many women leave without a clear diagnosis or experience recurrent symptoms despite treatment. The 3 most common etiologies of vaginitis are trichomonas, bacterial vaginosis, and vulvovaginal candidiasis, which account for an estimated 70% of cases. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.09.001DOI Listing
February 2020
12 Reads

Mucous Membrane Pemphigoid Presenting With Esophageal Manifestations: A Case Series.

Am J Gastroenterol 2019 10;114(10):1695-1697

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000393DOI Listing
October 2019

[Recalcitrant cicatrizing conjunctivitis. Treatment of nine patients with rituximab].

Medicina (B Aires) 2019 ;79(4):299-302

Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.

Cicatrizing conjunctivitis is the final consequence of several diseases. The most severe among them are cicatricial pemphigoid and chronic Stevens-Johnson syndrome. Systemic immunosuppressive drugs and steroids are usually an effective approach to these diseases. Read More

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September 2019
6 Reads

Childhood ocular mucous membrane pemphigoid successfully treated with rituximab.

Pediatr Dermatol 2019 Nov 25;36(6):984-985. Epub 2019 Aug 25.

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Ocular mucous membrane pemphigoid (MMP) is a chronic autoimmune blistering disease that usually affects elderly patients being extremely rare in pediatric population. Despite aggressive immunosuppressive therapy, ocular MMP may progress causing significant morbidity. Herein, we describe a toddler with ocular MMP successfully treated with rituximab. Read More

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http://dx.doi.org/10.1111/pde.13971DOI Listing
November 2019
1 Read

Novel diagnostic method to differentiate antilaminin-332 pemphigoid from other forms of pemphigoid.

Br J Dermatol 2020 02 25;182(2):270-271. Epub 2019 Aug 25.

Department of Dermatology, St George Hospital, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1111/bjd.18372DOI Listing
February 2020

Contribution to oral and maxillary surgery and surgical technique of osteo-odontokeratoprosthesis in Japan.

Br J Oral Maxillofac Surg 2019 11 2;57(9):861-865. Epub 2019 Aug 2.

Department of Oral and Maxillofacial Surgery, Kindai University, Faculty of Medicine, Japan.

Osteo-odontokeratoprosthesis (OOKP) is a technique invented by Strampelli in 1963, in which the patient's own tooth root is used to support an optical cylinder. It uses an autologous tooth-bone-periodontal complex to mount an optical cylinder, which is stabilised by overlying autologous buccal mucosa. OOKP involves two, staged procedures done by ophthalmologists and oral surgeons, and the main contribution from the oral surgeon is during the first stage. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.07.001DOI Listing
November 2019
6 Reads

A rare case of angina bullosa hemorrhagica of the esophagus.

Endoscopy 2019 12 30;51(12):E408-E409. Epub 2019 Jul 30.

Gastroenterology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

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http://dx.doi.org/10.1055/a-0962-9656DOI Listing
December 2019
1 Read
5.053 Impact Factor

[Rituximab use in mucous membrane pemphigoid].

Ann Dermatol Venereol 2019 Oct 26;146(10):659-661. Epub 2019 Jul 26.

Inserm U1058, Département de dermatologie, université de Montpellier, 34000 Montpellier, France.

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http://dx.doi.org/10.1016/j.annder.2019.07.001DOI Listing
October 2019
2 Reads

Clinical Characteristics and Outcomes of Ocular Cicatricial Pemphigoid: A Cohort Study and Literature Review.

Cornea 2019 Nov;38(11):1406-1411

Department of Internal Medicine, Centre Hospitalier Universitaire, Toulouse, France.

Purpose: Ocular cicatricial pemphigoid (OCP) is a rare systemic autoimmune disease and a potentially blinding subepithelial blistering disorder. The purpose of this study was to describe the clinical spectrum of the disease and to assess the efficacy and safety of immunosuppressive agents in a cohort of patients with OCP.

Methods: We conducted a monocentric retrospective cross-sectional cohort study of all unselected consecutive patients diagnosed with progressive OCP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002080DOI Listing
November 2019
3 Reads

Clinical Outcome of Autologous Cultivated Oral Mucosal Epithelial Transplantation in Ocular Surface Reconstruction.

Cornea 2019 Oct;38(10):1273-1279

C J Shah Cornea Services, Dr. G. Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To evaluate the outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) in ocular surface reconstructive procedures.

Methods: Twenty-five eyes of 24 patients who underwent COMET for ocular surface reconstruction were studied retrospectively from April 2011 to March 2014. Oral mucosal biopsy of 2 mm was harvested from all patients and cultured on amniotic membrane for 14 days. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002082DOI Listing
October 2019
9 Reads

Ocular mucous membrane pemphigoid: a review.

Immunol Res 2019 06;67(2-3):280-289

IRCCS - Fondazione Bietti, Rome, Italy.

Ocular mucous membrane pemphigoid (MMP) is a rare, immuno-mediated chronic progressive condition of the conjunctiva characterized by blisters developing from sub-epithelial tissue through disruption of the adhesions between the conjunctival epithelium and the sub-epithelium. Patients with ocular MMP, in many cases, develop profound conjunctival scarring and visual impairment. Furthermore, ocular MMP may lead to a progressive secondary corneal vascularization and to corneal opacification. Read More

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http://dx.doi.org/10.1007/s12026-019-09087-7DOI Listing
June 2019
8 Reads

Ectodermal Dysplasia: Association with Anti-Basement Membrane Autoantibodies.

Ocul Immunol Inflamm 2020 May 3;28(4):703-707. Epub 2019 Jul 3.

Department of Ophthalmology, Hospital de Clínicas José de San Martin, Universidad de Buenos Aires (UBA) , Buenos Aires, Argentina.

Ectodermal dysplasia (ED) is a group of several genetic conditions with absence or dysgenesis of at least two ectodermal derivatives: teeth, skin and its appendages including hair, nails, eccrine and sebaceous glands. The most important clinical findings in patients with ED are hypodontia, hypotrichosis, and hypohidrosis, which can lead to episodes of hyperthermia. Few reports have focused on the progressive keratopathy in ED. Read More

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http://dx.doi.org/10.1080/09273948.2019.1609526DOI Listing
May 2020
4 Reads

[Pseudopemphigoid Induced by Topical Glaucoma Medications].

Klin Monbl Augenheilkd 2019 Jun 13;236(6):762-766. Epub 2019 Jun 13.

Klinik für Augenheilkunde, Universitätsklinikum Düsseldorf, Düsseldorf.

Pseudopemphigoid is a chronic disease that causes progressive conjunctival scarring, up to symplepharon formation. Phenotypically, it cannot be distinguished from true mucous membrane pemphigoid with ocular involvement. Possible triggers are ocular surface disorders and/or their therapy. Read More

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http://dx.doi.org/10.1055/a-0842-7566DOI Listing
June 2019
5 Reads

Microbial Keratitis and Ocular Surface Disease: A 5-Year Study of the Microbiology, Risk Factors and Clinical Outcomes in Sydney, Australia.

Curr Eye Res 2019 11 24;44(11):1195-1202. Epub 2019 Jun 24.

The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, Australia.

: To report the microbiological and clinical profiles, and outcomes of patients with microbial keratitis who had ocular surface disease (OSD) at the Sydney Eye Hospital, Australia over a 5-year period.: A retrospective case-series study was conducted. Patients diagnosed with microbial keratitis who had a history of OSD (dry eye, blepharitis, Steven Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP)) from 1 January 2012 to 31 December 2016 were identified from hospital coding and pathology data. Read More

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http://dx.doi.org/10.1080/02713683.2019.1631852DOI Listing
November 2019
6 Reads

Gastrointestinal symptoms, gastrointestinal bleeding and the role of diet in patients with autoimmune blistering disease: a survey of the International Pemphigus and Pemphigoid Foundation.

J Eur Acad Dermatol Venereol 2019 Oct 2;33(10):1935-1940. Epub 2019 Jul 2.

Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.

Background: Autoimmune blistering diseases are a group of severe mucocutaneous conditions that typically require the use of prolonged corticosteroids and immunosuppression. Properly managing associated comorbidities is an integral part of these patients' care. The frequency of gastrointestinal symptoms, particularly gastrointestinal bleeding in these patients, is not known. Read More

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http://dx.doi.org/10.1111/jdv.15731DOI Listing
October 2019
8 Reads

Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita - Brazilian Society of Dermatology.

An Bras Dermatol 2019 Apr 30;94(2 Suppl 1):33-47. Epub 2019 Jun 30.

Department of Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases whose antigenic target is located at the basement membrane zone. Mucous membrane pemphigoid and epidermolysis bullosa acquisita can evolve with cicatricial mucosal involvement, leading to respiratory, ocular and/or digestive sequelae with important morbidity. For each of these dermatoses, a literature review covering all therapeutic options was performed. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/abd1806-4841.2019940207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544032PMC
April 2019
9 Reads

Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis.

J Coll Physicians Surg Pak 2019 Jun;29(6):S34-S36

Department of Medicine, Patel Hospital, Gulshan-e-Iqbal, Karachi, Pakistan.

Ocular cicatricial pemphigoid (OCP) is a rare autoimmune disease with heterogenous clinical manifestations. The classical lesion involves ocular conjunctiva that leads to progressive scarring and fibrosis which ultimately results in visual loss. We report a case of a young male, who had chronic conjunctivitis which remained un-responsive to conventional treatment and results in significant morbidity. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.06.S34DOI Listing
June 2019
8 Reads
0.318 Impact Factor

World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus.

Oral Dis 2019 Jun;25 Suppl 1:111-121

School of Dentistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Objective: To assess the evidence for treatment of oral involvement of pemphigus and pemphigoid with biologics.

Study Design: This systematic review used a comprehensive search strategy to identify literature describing oral involvement of pemphigus or pemphigoid treated with a biologic agent. The primary outcome measures were efficacy and safety of biologic therapy. Read More

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http://dx.doi.org/10.1111/odi.13083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544168PMC
June 2019
10 Reads

Mucous Membrane Pemphigoid-Associated Malignancies: Case Series and a Brief Overview of the Literature.

Dermatol Pract Concept 2019 Apr 30;9(2):119-125. Epub 2019 Apr 30.

Dermatology Division, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Background: Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. Current literature has shown that a minority of patients present circulating antibodies to laminin-332 and this population seems to be associated with a relatively high risk of malignancy.

Objective: To present our personal case series of patients with MMP-associated malignancy from a dermatology university hospital. Read More

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https://dpcj.org/index.php/dpc/article/view/dermatol-pract-c
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http://dx.doi.org/10.5826/dpc.0902a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502303PMC
April 2019
7 Reads

Mucous membrane pemphigoid and oral blistering diseases.

Clin Exp Dermatol 2019 Oct 18;44(7):732-739. Epub 2019 May 18.

Oral Medicine, Dental Institute, Guy's and St Thomas' NHS Foundation Trust, London, UK.

The autoimmune blistering disorders present with variable frequency in the oral cavity. Recognition of their key clinical features at presentation is important, as there are many causes of oral ulceration. Careful history-taking, clinical examination, an understanding of pathogenesis and appropriate investigations are essential. Read More

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http://dx.doi.org/10.1111/ced.13996DOI Listing
October 2019
13 Reads

Oral autoimmune vesicobullous diseases: Classification, clinical presentations, molecular mechanisms, diagnostic algorithms, and management.

Periodontol 2000 2019 06;80(1):77-88

Oral Medicine Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, Naples, Italy.

Mucocutaneous blistering autoimmune diseases are a group of systemic, rare, chronic disorders characterized by humoral-mediated immunologic mechanisms against epithelial, basement membrane, and subepithelial tissues. Morbidity and mortality can be completely different among these diseases, with outcome being dependent on an early and accurate diagnosis, systemic comorbidities, and the patient's response to treatment. Definitive diagnosis is based on clinical and histopathologic findings. Read More

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http://dx.doi.org/10.1111/prd.12263DOI Listing
June 2019
11 Reads

Pharyngeal obstruction due to hemorrhagic bullae in a patient with anti-BP180-type mucous membrane pemphigoid associated with acquired hemophilia A.

J Dermatol 2019 10 7;46(10):e375-e376. Epub 2019 May 7.

Department of Dermatology, Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/1346-8138.14908DOI Listing
October 2019
5 Reads

[Anti-laminin 332 mucous membrane pemphigoid with irreversible ocular and tracheobronchial involvement : Delayed diagnosis of a severe autoimmune bullous disease].

Hautarzt 2019 May;70(5):367-370

Klinik für Dermatologie, Allergologie und Venerologie, Universität Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

A 53-year-old man presented with a 37-year history of erosive and scarring mucosal lesions of several organs. An initial diagnosis of Stevens-Johnson syndrome was maintained for many years. Due to late correct diagnosis of an anti-laminin 332 mucous membrane pemphigoid and the fact that early, targeted, intensified immunosuppressive therapy was not initiated, the disease led to almost complete loss of vision and obstruction of airways. Read More

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http://dx.doi.org/10.1007/s00105-019-4402-zDOI Listing
May 2019
3 Reads

Circulating bullous pemphigoid autoantibodies in the setting of negative direct immunofluorescence findings for bullous pemphigoid: A single-center retrospective review.

J Am Acad Dermatol 2019 Aug 28;81(2):472-479. Epub 2019 Mar 28.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Bullous pemphigoid (BP) autoantibody levels are generally elevated in patients with BP but can be present nonspecifically in patients without BP.

Objective: To analyze the clinical findings of patients with elevated BP180 or BP230 autoantibody levels and negative direct immunofluorescence (DIF) study findings.

Methods: We retrospectively reviewed records of patients seen at our institution during January 1, 2005-December 31, 2015, who were positive for BP180 or BP230 autoantibodies and had a negative DIF study finding. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.062DOI Listing
August 2019
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Treatment Update of Autoimmune Blistering Diseases.

Dermatol Clin 2019 Apr 14;37(2):215-228. Epub 2019 Feb 14.

Department of Medicine, University of Central Florida, Health Sciences Campus at Lake Nona, 2627 Northampton Avenue, Orlando, FL 32827-7408, USA. Electronic address:

The treatment of refractory autoimmune blistering diseases (AIBDs) has always been a challenge. Because randomized controlled trials are lacking, treatment has been based on analysis of anecdotal data. The last 2 decades has seen the use of rituximab become a conventional treatment in the therapeutic armamentarium of AIBDs, leading to its Food and Drug Administration indication for pemphigus vulgaris in 2018. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.003DOI Listing
April 2019
10 Reads

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e136-e144. Epub 2019 Mar 1.

Department of Oral Medicine, Faculty of Medicine and Sciences of the Health, Julian Clavería, 33006 Oviedo, Spain,

Background: The aim of this present article was to evaluate the scientific evidence on the efficacy of daily hygiene and professional prophylaxis for treatment of desquamative gingivitis.

Material And Methods: The present systematic review was conducted following the PRISMA protocol. Searches were carried out in Pubmed, Embase, Web of Science and Cochrane Library up to July 2018, randomized clinical trials and cohort studies on desquamative gingivitis (DG), and oral diseases joined to DG. Read More

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http://dx.doi.org/10.4317/medoral.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441599PMC
March 2019
4 Reads

Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.

Autoimmun Rev 2019 Apr 7;18(4):349-358. Epub 2019 Feb 7.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy. Electronic address:

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.02.005DOI Listing
April 2019
44 Reads

A conjunctival-sparing surgical technique for lower eyelid cicatricial entropion repair in ocular cicatricial pemphigoid.

Orbit 2020 Feb 7;39(1):23-30. Epub 2019 Feb 7.

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

: To present five cases of lower eyelid cicatricial entropion secondary to ocular cicatricial pemphigoid (OCP) successfully repaired with a conjunctival-sparing surgical technique.: The records of one surgeon (SKF) were reviewed to identify patients with lower eyelid cicatricial entropion secondary to OCP who underwent repair with a conjunctival-sparing technique between September 1, 2016 and October 18, 2017. The medical records were reviewed and extracted data included: age, gender, past medical history, current medical and OCP status, clinical examination, details of entropion repair surgery, and outcome. Read More

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http://dx.doi.org/10.1080/01676830.2019.1573434DOI Listing
February 2020
7 Reads

Mucous membrane pemphigoid of the oral lichen type: a retrospective analysis of 16 cases.

J Eur Acad Dermatol Venereol 2019 May 1;33(5):e205-e207. Epub 2019 Mar 1.

Department of Dermatology, Inselspital - Bern University Hospital, Bern, Switzerland.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15473
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http://dx.doi.org/10.1111/jdv.15473DOI Listing
May 2019
4 Reads

Mucous membrane pemphigoid-associated paronychia with onychomadesis.

BMC Dermatol 2019 01 23;19(1). Epub 2019 Jan 23.

Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare.

Case Presentation: We report on a 58 years old man with severe MMP who presented with onychomadesis. Read More

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http://dx.doi.org/10.1186/s12895-019-0083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343326PMC
January 2019
12 Reads