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    1 OF 32

    Vitreoretinal Complications and Outcomes in 92 Eyes Undergoing Surgery for Modified Osteo-Odonto-Keratoprosthesis: A 10-Year Review.
    Ophthalmology 2018 Jan 13. Epub 2018 Jan 13.
    CJ Shah Cornea Services and Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Chennai, India.
    Purpose: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery.

    Design: Retrospective case series.

    Participants: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. Read More

    Atopy in Patients With Ocular Cicatricial Pemphigoid.
    Cornea 2018 Jan 16. Epub 2018 Jan 16.
    Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA.
    Purpose: To evaluate the presence of atopy in patients with ocular cicatricial pemphigoid (OCP).

    Method: Patient encounters between August 2005 and November 2016 at the Massachusetts Eye Research and Surgery Institute (MERSI) were searched to identify those with biopsy-proven OCP who had concurrent evidence of atopy.

    Results: There were 230 patients with biopsy-proven OCP. Read More

    An unusual presentation of ocular rosacea.
    Arq Bras Oftalmol 2017 Nov-Dec;80(6):396-398
    Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
    Rosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Read More

    Cataract surgery in ocular surface diseases: clinical challenges and outcomes.
    Curr Opin Ophthalmol 2018 Jan;29(1):81-87
    Cornea service, Nethradhama Eye Hospital, Bangalore, Karnataka, India.
    Purpose Of Review: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. Read More

    Oral Manifestation in Patients diagnosed with Dermatological Diseases.
    J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.
    Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.
    Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

    Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

    Long-term remission of ocular cicatricial pemphigoid off immunomodulatory therapy.
    Eur J Ophthalmol 2017 Oct 14. Epub 2017 Oct 14.
    Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA - USA.
    Purpose: To evaluate whether long-term remission of ocular cicatricial pemphigoid (OCP) after withdrawal of immunomodulatory therapy (IMT) is possible.

    Methods: A total of 34 of 464 presenting patients (66 eyes) with biopsy-proven OCP in long-term remission off IMT were identified after finishing a 2-year IMT regimen without active disease (2005-2015). Long-term remission off IMT for OCP was defined as patients withdrawn from IMT ≥1 year lacking clinically detectable progressive scarring according to Foster staging and subjective assessment. Read More

    Ocular features of multiple system atrophy.
    J Clin Neurosci 2018 Jan 21;47:234-239. Epub 2017 Oct 21.
    Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA. Electronic address:
    The aim of this paper is to gain better understanding of the ocular manifestations of multiple system atrophy (MSA), a neurodegenerative disorder rarely studied in terms of its ophthalmologic features. We performed a retrospective case series (1/1/05-12/31/14) to search for patients seen at Mayo Clinic, Rochester, MN, who had mention of MSA in the medical record and an eye examination, which yielded 285 cases. Of the 285, we identified 39 cases of true MSA. Read More

    Spectrum of orocutaneous disease associations: Immune-mediated conditions.
    J Am Acad Dermatol 2017 Nov;77(5):795-806
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

    Pure mucinous (colloid) adenocarcinoma of the conjunctiva.
    J Cutan Pathol 2018 Jan 8;45(1):78-83. Epub 2017 Nov 8.
    Department of Dermatology, Section of Dermatopathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Primary mucinous carcinomas of the periorbital region are very rare and often require differential diagnosis of metastatic disease. We describe a case of pure mucinous adenocarcinoma arising in the subconjunctival stroma of the ocular fornix in a female patient with a longstanding history of bilateral ocular cicatricial pemphigoid. Histologically, the tumor was composed of predominantly goblet-like cells floating in pools of mucin separated by delicate collagenous septa. Read More

    Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases.
    Am J Ophthalmol 2017 Dec 5;184:42-51. Epub 2017 Oct 5.
    Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.
    Purpose: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases.

    Design: Prospective consecutive case series.

    Methods: This study includes 14 patients (aged 62. Read More

    Minor Salivary Gland Transplantation for Severe Dry Eyes.
    Cornea 2017 Nov;36 Suppl 1:S26-S33
    *Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; and†Department of Pathology, LIM 14, São Paulo University School of Medicine, São Paulo, Brazil.
    Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness. Read More

    Clinical Implications of Direct Immunofluorescence Findings in Patients With Ocular Mucous Membrane Pemphigoid.
    Am J Ophthalmol 2017 Nov 30;183:48-55. Epub 2017 Aug 30.
    Ophthalmology, Duke University Eye Center, Durham, North Carolina.
    Purpose: To examine the clinical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP).

    Design: Retrospective cohort study.

    Methods: The study population was patients with clinically typical ocular MMP disease with documented DIF results who were followed for at least 1 year at the Duke University multidisciplinary ocular MMP clinic. Read More

    Determining the Incidence of Pneumocystis Pneumonia in Patients With Autoimmune Blistering Diseases Not Receiving Routine Prophylaxis.
    JAMA Dermatol 2017 Nov;153(11):1137-1141
    Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    Importance: Pneumocystis pneumonia (PCP) is a potentially lethal opportunistic infection that primary prophylaxis can help prevent. The risk of prophylactic therapy must be weighed against the incidence of PCP in the patient population. Prophylaxis most frequently involves trimethoprim-sulfamethoxazole, with second-line therapies, including atovaquone, dapsone, and pentamide. Read More

    Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
    A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. Read More

    Mucocutaneous Diseases: Oral Lichen Planus, Mucous Membrane Pemphigoid and Pemphigus Vulgaris.
    J Calif Dent Assoc 2016 Sep;44(9):561-70
    Mucocutaneous diseases affect the oral cavity and can present a diagnostic challenge. They can have systemic involvement, necessitating multidisciplinary management. Frequently, patients will see their general dentists initially for evaluation. Read More

    Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid.
    J Am Acad Dermatol 2017 Oct 1;77(4):700-705.e3. Epub 2017 Jul 1.
    Department of Dermatology, University of Lübeck, Lübeck, Germany.
    Background: Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by the predominant blistering of mucosal surfaces and the linear deposition of complement, IgG, or IgA along the basement membrane detected by direct immunofluorescence (DIF) test.

    Objective: To assess the impact of multiple and repeated DIF sampling on establishing the diagnosis of MMP.

    Methods: We reviewed the results of DIF studies in 136 nonlesional biopsies from 78 patients who were immunologically confirmed to have MMP. Read More

    [A particular type of cicatricial Pemphigoid with unique IgA deposit].
    Pan Afr Med J 2017 13;26:136. Epub 2017 Mar 13.
    Université de Sousse, Tunisie.
    Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Read More

    Conjunctival Squamous Cell Neoplasia Associated With Ocular Cicatricial Pemphigoid.
    Ophthal Plast Reconstr Surg 2017 Nov/Dec;33(6):e157-e160
    *Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, †Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, ‡David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, §Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, and ‖Cornea and Refractive Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.
    The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. Read More

    Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease.
    J Invest Dermatol 2017 Aug 26;137(8):1709-1718. Epub 2017 Apr 26.
    Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany; Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:
    Mucous membrane pemphigoid is an autoantibody-mediated disease predominantly affecting the oral cavity, pharynx, and conjunctiva. Conjunctival lesions may lead to impaired vision and, finally, blindness. About 25% of mucous membrane pemphigoid patients generate autoantibodies against the α3 chain of laminin 332 (LAMα3), a structural protein of epidermal/epithelial basement membranes. Read More

    Oesophageal involvement in 26 consecutive patients with mucous membrane pemphigoid.
    Br J Dermatol 2017 Oct 1;177(4):1074-1085. Epub 2017 Oct 1.
    Department of Dermatology and Referral Center for Auto-Immune Bullous Diseases, Avicenne Hospital, APHP, University Paris 13, 93009, Bobigny, France.
    Background: Oesophageal involvement of mucous membrane pemphigoid (MMP) has not yet been thoroughly described.

    Objectives: To characterize systematically the endoscopic lesions of a series of patients with oesophageal symptoms seen at a referral centre for autoimmune bullous diseases.

    Methods: Clinical, endoscopic and immunological findings of consecutively referred patients with MMP with oesophageal involvement, systemic and endoscopic treatments, and follow-up are described. Read More

    Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017;15(2):177-182
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    [Dermatoses and herpes superinfection: A retrospective study of 34 cases].
    Ann Dermatol Venereol 2017 Mar 24;144(3):176-181. Epub 2017 Feb 24.
    Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France. Electronic address:
    Background: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated.

    Aim: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department.

    Patients And Methods: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis. Read More

    Rituximab in the treatment of ocular cicatricial pemphigoid: a retrospective cohort study.
    Graefes Arch Clin Exp Ophthalmol 2017 Jun 3;255(6):1221-1228. Epub 2017 Feb 3.
    Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.
    Purpose: The purpose was to evaluate the effectiveness and safety of rituximab (RTX) for the treatment of patients with aggressive ocular cicatricial pemphigoid (OCP).

    Methods: A review of patient records at a tertiary referral center with biopsy confirmed OCP who presented between 2006 and 2016. Sixty-one eyes of 32 patients with symptomatic OCP who received treatment with RTX monotherapy or RTX in combination with additional immunomodulatory treatment (IMT) were evaluated. Read More

    The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on.
    Eye (Lond) 2017 Feb 20;31(2):301-332. Epub 2017 Jan 20.
    Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.
    This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. Read More

    Periocular Amyloidosis Manifesting as Pseudopemphigoid Treated With Mitomycin C.
    Cornea 2017 Apr;36(4):518-520
    *Oculoplastics Department, Royal Eye Infirmary, Derriford Hospital, Plymouth, United Kingdom; and †Histopathology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
    Purpose: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy.

    Methods: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Read More

    Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient.
    J Glaucoma 2017 Apr;26(4):e146-e149
    *Glaucoma Service ‡Cornea Service §Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA †Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    We describe the surgical technique of endoscopic cyclophotocoagulation in a Boston keratoprosthesis type II patient. This patient with ocular cicatricial pemphigoid had pars plana endoscopic cyclophotocoagula through wounds created in the eyelids. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature.
    J Res Med Sci 2016 14;21:37. Epub 2016 Jun 14.
    Department of Dermatology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond.

    Materials And Methods: PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as "cicatricial pemphigoid" or "ocular pemphigoid" or "mucous membrane pemphigoid" or "MMP" and "intravenous immunoglobulin" or "IVIg" to find all the relevant studies. Read More

    Autoimmune Blistering Diseases in the Elderly: Clinical Presentations and Management.
    Drugs Aging 2016 Oct;33(10):711-723
    Department of Dermatology, St. George Hospital, Gray St, Kogarah, Sydney, 2217, NSW, Australia.
    Elderly patients are more susceptible to the development of autoimmune blistering disorders such as bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and paraneoplastic pemphigus. This article focuses on the clinical aspects of the aforementioned autoimmune blistering diseases and highlights the important factors involved in treating elderly patients. It is essential for clinicians to offer individualized treatment plans for these patients to optimize outcomes, as elderly patients often have multiple co-morbidities, polypharmacy, and suboptimal socioeconomic status that can adversely influence adequate compliance. Read More

    Conjunctival Neutrophils Predict Progressive Scarring in Ocular Mucous Membrane Pemphigoid.
    Invest Ophthalmol Vis Sci 2016 Oct;57(13):5457-5469
    Academic Unit of Ophthalmology, Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom 2Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom.
    Purpose: Ocular mucous membrane pemphigoid (OcMMP) is a rare autoimmune disorder resulting in progressive conjunctival fibrosis and ocular surface failure leading to sight loss in up to 50%. This study was designed to optimize an ocular surface sampling technique for identification of novel biomarkers associated with disease activity and/or progressive fibrosis.

    Methods: Fifty-seven patients with OcMMP underwent detailed examination of conjunctival inflammation and fibrosis using fornix depth measurement. Read More

    Combined Use of Rituximab and Intravenous Immunoglobulin for Severe Autoimmune Cicatricial Conjunctivitis-An Interventional Case Series.
    Cornea 2016 Dec;35(12):1611-1614
    *Department of Corneal and External Eye Diseases, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom;†Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria;‡Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom; and§Department of Nephrology, Royal Liverpool University Hospital, Liverpool, United Kingdom.
    Purpose: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC.

    Methods: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1-3) and 1 case with linear IgA disease (patient 4) were included. Read More

    [Involvement of mucous membranes in autoimmune bullous diseases].
    Hautarzt 2016 Oct;67(10):774-779
    Klinik und Poliklinik für Dermatologie, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
    Autoimmune bullous diseases are characterized by intraepidermal or subepidermal autoantibody deposition that leads to blisters and secondary erosion. Mucous membranes are frequently affected in pemphigus vulgaris and always involved in cicatricial and mucosal pemphigoid. Mucosal lesions are detected less frequently in patients with bullous pemphigoid or epidermolysis bullosa acquisita. Read More

    [Lesions of the oral mucosa : Differential diagnostic approach from the maxillofacial surgeon's perspective].
    Hautarzt 2016 Oct;67(10):816-821
    Universitätsklinik für Mund-, Kiefer- und Gesichtschirurgie, Uniklinikum Salzburg, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.
    A detailed medical history and a careful clinical examination are the basis for developing a list of possible differential diagnoses in lesions of the oral mucosa. On this basis, it can be decided whether a lesion can be observed for 14 days after removal of possible causes or the start of a trial treatment, or whether a biopsy for histological examination must be taken immediately. An excisional biopsy is performed for small and presumably benign lesions, an incisional biopsy for large and presumably malignant lesions. Read More

    [Mucosal diseases from an allergological perspective].
    Hautarzt 2016 Oct;67(10):780-785
    Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

    [Inflammatory diseases of oral mucous membranes].
    Hautarzt 2016 Oct;67(10):786-792
    Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstr. 9-11, 80337, München, Deutschland.
    Background: Mucous membranes are involved in many different inflammatory disorders.

    Methods: We describe the clinical features, diagnostic workup, and therapy of inflammatory diseases of mucous membranes.

    Results: The diagnostic workup is based on medical history, clinical manifestations, histopathology, and serology. Read More

    Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid.
    J Indian Soc Periodontol 2016 May-Jun;20(3):340-3
    Department of Dentistry, JIPMER, Puducherry, India.
    Desquamative gingivitis (DG) is a clinical condition in which the gingiva appears reddish, glazed, and friable with loss of superficial epithelium. DG is considered a clinical manifestation of many gingival diseases and hence not identified as a diagnosis itself. Mucous membrane pemphigoid (MMP) is an autoimmune vesiculobullous disorder of mucous membrane characterized by subepithelial bullae formation. Read More

    Conjunctival cicatrizing disease presenting with lacrimal obstruction.
    Orbit 2016 Dec 25;35(6):321-323. Epub 2016 Aug 25.
    a Orbital Plastic and Lacrimal Clinic , Royal Victorian Eye and Ear Hospital , Melbourne , Australia.
    Patients with conjunctival cicatrizing disease may develop lacrimal obstruction. Little is published on lacrimal obstruction as the presenting feature of otherwise asymptomatic cicatrizing conjunctival disease. The records of all patients presenting between 1994 and 2015 with lacrimal obstruction found to have cicatrizing conjunctival disease were reviewed. Read More

    [Mucosal manifestations of epidermolysis bullosa : Clinical presentation and management].
    Hautarzt 2016 Oct;67(10):806-815
    Universitätsklinik für Dermatologie, Universitätsklinikum Salzburg, Müllner Hauptstr. 48, 5020, Salzburg, Österreich.
    Mucosal lesions occur with different prevalence and severity in all subtypes of hereditary epidermolysis bullosa (EB), a group of rare genodermatoses. They are associated with increased morbidity and mortality, especially in severe junctional and dystrophic subtypes. Despite progress in clinical approaches to curative therapy, the management of these patients is still primarily symptom-oriented. Read More

    Successful treatment with oral mizoribine in refractory ocular manifestation of mucosal pemphigus vulgaris: A unique response to different immunosuppressive drugs.
    Dermatol Ther 2016 Nov 15;29(6):442-445. Epub 2016 Jul 15.
    Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, Yatsuyamada, Koriyama, Fukushima, 963-8563, Japan.
    Pemphigus vulgaris (PV) is an acquired autoimmune disease in which the disease characteristic antibodies are directed against the desmosomal transmembrane glycoprotein, desmoglein 3 (Dsg 3), resulting in flaccid blisters and erosions of skin and mucous membrane. Among various affected sites, ocular involvement may often persist or relapse even after remission of other mucocutaneous lesions, and also represent a higher morbidity. We describe such an example case of mucosal PV, whose oral and ocular manifestations were responded specifically to oral cyclosporine and mizoribine, respectively. Read More

    Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases.
    Vet Dermatol 2016 Oct 28;27(5):376-e94. Epub 2016 Jun 28.
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    Background: Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepidermal blistering disease of dogs, cats and humans.

    Objectives: The goal of this study was to describe the clinical, histological and immunological features and treatment outcomes of canine MMP.

    Animals: Sixteen dogs were diagnosed with MMP based on the presence of mucosal- or mucocutaneous-predominant vesiculation and/or ulceration, histological confirmation of subepidermal clefting and an age of disease onset greater than 6 months. Read More

    Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid.
    Int J Ophthalmol 2016 18;9(5):730-7. Epub 2016 May 18.
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Aim: To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy (IVCM) in patients with ocular cicatricial pemphigoid (OCP).

    Methods: A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. Read More

    Clinical and immunological study of mucous membrane pemphigoid in a cohort of Indian patients.
    Int J Dermatol 2016 Oct 3;55(10):e557-61. Epub 2016 Jun 3.
    Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan.

    Integrin β4 is a major target antigen in pure ocular mucous membrane pemphigoid.
    Eur J Dermatol 2016 Jun;26(3):247-53
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka.
    Previous studies of ocular mucous membrane pemphigoid (OMMP) have identified several components of the basement membrane zone to be autoantigens, including integrin β4. However, there are no extensive or definitive reported studies that address this, particularly in pure OMMP. To clarify the major autoantigens in pure OMMP. Read More

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