1,614 results match your criteria Cicatricial Pemphigoid


A case of antiepiligrin cicatricial pemphigoid with extensive cutaneous erosions mimicking pemphigus vulgaris.

BMJ Case Rep 2018 Jun 21;2018. Epub 2018 Jun 21.

Department of Dermatology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Cicatricial pemphigoid (CP) is a chronic, autoimmune, subepidermal blistering disease with predominant mucosal involvement. In this article, we report a young patient with mucosal and extensive cutaneous involvement in the form of large erosions mimicking those of pemphigus vulgaris thus leading to diagnostic dilemma. We were unable to find any other previous reports with such extensive cutaneous erosions mimicking those of pemphigus vulgaris. Read More

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June 2018
1 Read

Adrenocorticotropic hormone analogue as novel treatment regimen in ocular cicatricial pemphigoid.

Am J Ophthalmol Case Rep 2018 Jun 20;10:264-267. Epub 2018 Mar 20.

Metropolitan Eye Research and Surgery Institute, Palisades Park, NJ, USA.

Purpose: To report the clinical outcome of a patient with ocular cicatricial pemphigoid, treated with adrenocorticotropic hormone gel.

Observations: A 75-year-old female with a biopsy proven ocular cicatricial pemphigoid (OCP) presented with bilateral conjunctival inflammation, fornix shortening, subepithelial fibrosis and corneal scarring. The patient was previously treated with topical steroids, topical cyclosporine and lubricating drops, and had undergone several amniotic membrane transplants due to recurrent corneal erosions. Read More

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Desquamative gingivitis: Clinical findings and diseases.

J Am Acad Dermatol 2018 May;78(5):839-848

Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Dermatology, Weill Cornell Medical College, New York, New York.

Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Read More

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May 2018
1 Read

Incidence and Clinical Characteristics of Ocular Involvement in Mucous Membrane Pemphigoid.

Ocul Immunol Inflamm 2018 Apr 19:1-5. Epub 2018 Apr 19.

a Wilmer Eye Institute , Johns Hopkins University School of Medicine , Baltimore , Maryland , USA.

Purpose: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement.

Methods: Retrospective chart review of 162 biopsy-proven MMP patients.

Results: At presentation, 109 of 162 MMP patients (67. Read More

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[Autologous serum tears: Long-term treatment in dry eye syndrome].

J Fr Ophtalmol 2018 Mar 27;41(3):246-254. Epub 2018 Mar 27.

Service d'ophtalmologie, CHU de Hôpital La Timone, 264, rue Saint-Pierre, 13385 Marseille, France.

Introduction: Dry eye disease is a multifactorial pathology of the ocular surface. The high incidence of this pathology, as well as its significant impact on quality of life and vision and its financial cost, makes it a real public health problem. While the treatment of mild cases is generally simple and effective, treatment of severe forms is often disappointing. Read More

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March 2018
8 Reads

A case with corneal perforation due to bacterial concretion derived from lacrimal canaliculitis.

Am J Ophthalmol Case Rep 2018 Mar 12;9:116-118. Epub 2018 Jan 12.

Department of Ophthalmology, Saitama Medical University, Saitama, Japan.

Purpose: To report a case with corneal perforation, presumably due to ocular cicatricial pemphigoid (OCP) and bacterial concretion derived from lacrimal canaliculitis.

Observations: A patient with OCP demonstrated adherence of concretion to the cornea of her right eye. She also demonstrated canaliculitis in this eye. Read More

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March 2018
1 Read

Management of Ocular Cicatricial Pemphigoid with Intravenous Immunoglobulin Monotherapy.

Ocul Immunol Inflamm 2018 Mar 8:1-7. Epub 2018 Mar 8.

a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA.

Purpose: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP).

Methods: A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. Read More

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March 2018
1 Read

Vulval lichen planus-lichen sclerosus overlap.

Int J STD AIDS 2018 Jan 1:956462418758777. Epub 2018 Jan 1.

2 School of Medicine, 98475 Deakin University , Geelong, Australia.

Vulval lichen planus-lichen sclerosus overlap is an emerging observation. Few clinical reports exist with no reviews of literature. We present a focused update of this phenomenon and discuss a clinical case. Read More

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January 2018
6 Reads

Vitreoretinal Complications and Outcomes in 92 Eyes Undergoing Surgery for Modified Osteo-Odonto-Keratoprosthesis: A 10-Year Review.

Ophthalmology 2018 Jun 17;125(6):832-841. Epub 2018 Jan 17.

CJ Shah Cornea Services and Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Chennai, India.

Purpose: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery.

Design: Retrospective case series.

Participants: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. Read More

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June 2018
6 Reads

Atopy in Patients With Ocular Cicatricial Pemphigoid.

Cornea 2018 Apr;37(4):436-441

Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA.

Purpose: To evaluate the presence of atopy in patients with ocular cicatricial pemphigoid (OCP).

Method: Patient encounters between August 2005 and November 2016 at the Massachusetts Eye Research and Surgery Institute (MERSI) were searched to identify those with biopsy-proven OCP who had concurrent evidence of atopy.

Results: There were 230 patients with biopsy-proven OCP. Read More

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April 2018
5 Reads

An unusual presentation of ocular rosacea.

Arq Bras Oftalmol 2017 Nov-Dec;80(6):396-398

Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.

Rosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Read More

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January 2017
4 Reads

Cataract surgery in ocular surface diseases: clinical challenges and outcomes.

Curr Opin Ophthalmol 2018 Jan;29(1):81-87

Cornea service, Nethradhama Eye Hospital, Bangalore, Karnataka, India.

Purpose Of Review: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. Read More

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January 2018
5 Reads

Oral Manifestation in Patients diagnosed with Dermatological Diseases.

J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.

Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

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December 2017
4 Reads

Long-term remission of ocular cicatricial pemphigoid off immunomodulatory therapy.

Eur J Ophthalmol 2018 Mar;28(2):157-162

1 Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA - USA.

Purpose: To evaluate whether long-term remission of ocular cicatricial pemphigoid (OCP) after withdrawal of immunomodulatory therapy (IMT) is possible.

Methods: A total of 34 of 464 presenting patients (66 eyes) with biopsy-proven OCP in long-term remission off IMT were identified after finishing a 2-year IMT regimen without active disease (2005-2015). Long-term remission off IMT for OCP was defined as patients withdrawn from IMT ≥1 year lacking clinically detectable progressive scarring according to Foster staging and subjective assessment. Read More

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March 2018
5 Reads

Ocular features of multiple system atrophy.

J Clin Neurosci 2018 Jan 21;47:234-239. Epub 2017 Oct 21.

Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA. Electronic address:

The aim of this paper is to gain better understanding of the ocular manifestations of multiple system atrophy (MSA), a neurodegenerative disorder rarely studied in terms of its ophthalmologic features. We performed a retrospective case series (1/1/05-12/31/14) to search for patients seen at Mayo Clinic, Rochester, MN, who had mention of MSA in the medical record and an eye examination, which yielded 285 cases. Of the 285, we identified 39 cases of true MSA. Read More

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January 2018
3 Reads

Endoscopic characteristics of oesophagus involvement in mucous membrane pemphigoid.

Authors:
H Yuan M Pan

Br J Dermatol 2017 10;177(4):902-903

Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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October 2017
1 Read

Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets.

Cornea 2018 Jan;37(1):76-83

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency.

Methods: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COMECs were prepared in a culture system without the use of any temperature-sensitive polymers or carriers. Read More

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January 2018
8 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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November 2017
6 Reads

Pure mucinous (colloid) adenocarcinoma of the conjunctiva.

J Cutan Pathol 2018 Jan 8;45(1):78-83. Epub 2017 Nov 8.

Department of Dermatology, Section of Dermatopathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Primary mucinous carcinomas of the periorbital region are very rare and often require differential diagnosis of metastatic disease. We describe a case of pure mucinous adenocarcinoma arising in the subconjunctival stroma of the ocular fornix in a female patient with a longstanding history of bilateral ocular cicatricial pemphigoid. Histologically, the tumor was composed of predominantly goblet-like cells floating in pools of mucin separated by delicate collagenous septa. Read More

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January 2018
10 Reads

Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases.

Am J Ophthalmol 2017 Dec 5;184:42-51. Epub 2017 Oct 5.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases.

Design: Prospective consecutive case series.

Methods: This study includes 14 patients (aged 62. Read More

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December 2017
1 Read

Minor Salivary Gland Transplantation for Severe Dry Eyes.

Cornea 2017 Nov;36 Suppl 1:S26-S33

*Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; and†Department of Pathology, LIM 14, São Paulo University School of Medicine, São Paulo, Brazil.

Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness. Read More

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November 2017
6 Reads

Clinical Implications of Direct Immunofluorescence Findings in Patients With Ocular Mucous Membrane Pemphigoid.

Am J Ophthalmol 2017 Nov 30;183:48-55. Epub 2017 Aug 30.

Ophthalmology, Duke University Eye Center, Durham, North Carolina.

Purpose: To examine the clinical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP).

Design: Retrospective cohort study.

Methods: The study population was patients with clinically typical ocular MMP disease with documented DIF results who were followed for at least 1 year at the Duke University multidisciplinary ocular MMP clinic. Read More

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November 2017
9 Reads

Determining the Incidence of Pneumocystis Pneumonia in Patients With Autoimmune Blistering Diseases Not Receiving Routine Prophylaxis.

JAMA Dermatol 2017 Nov;153(11):1137-1141

Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Importance: Pneumocystis pneumonia (PCP) is a potentially lethal opportunistic infection that primary prophylaxis can help prevent. The risk of prophylactic therapy must be weighed against the incidence of PCP in the patient population. Prophylaxis most frequently involves trimethoprim-sulfamethoxazole, with second-line therapies, including atovaquone, dapsone, and pentamide. Read More

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November 2017
9 Reads

Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement.

BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.

Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. Read More

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August 2017
17 Reads

Oral Manifestations of Autoimmune and Connective Tissue Disorders.

Atlas Oral Maxillofac Surg Clin North Am 2017 Sep;25(2):113-126

Department of Comprehensive Dentistry, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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September 2017
4 Reads

Mucocutaneous Diseases: Oral Lichen Planus, Mucous Membrane Pemphigoid and Pemphigus Vulgaris.

J Calif Dent Assoc 2016 Sep;44(9):561-70

Mucocutaneous diseases affect the oral cavity and can present a diagnostic challenge. They can have systemic involvement, necessitating multidisciplinary management. Frequently, patients will see their general dentists initially for evaluation. Read More

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September 2016
13 Reads

Reconstructive subperiosteal midface lift: A three nonvisible incision approach.

Orbit 2017 Oct 5;36(5):256-263. Epub 2017 Jul 5.

c Colmenero Clinic , Madrid , Spain.

This article describes our surgical technique for subperiosteal midface elevation in patients with paralytic lower eyelid malposition or cicatricial inferior eyelid retraction. Nineteen patients with paralytic lower eyelid malposition and 15 patients with cicatricial inferior eyelid retraction underwent a subperiosteal midface lift (n = 34). The procedure was performed under local anesthesia through three nonvisible incisions. Read More

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October 2017
4 Reads

Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid.

J Am Acad Dermatol 2017 Oct 1;77(4):700-705.e3. Epub 2017 Jul 1.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Background: Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by the predominant blistering of mucosal surfaces and the linear deposition of complement, IgG, or IgA along the basement membrane detected by direct immunofluorescence (DIF) test.

Objective: To assess the impact of multiple and repeated DIF sampling on establishing the diagnosis of MMP.

Methods: We reviewed the results of DIF studies in 136 nonlesional biopsies from 78 patients who were immunologically confirmed to have MMP. Read More

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October 2017

[A particular type of cicatricial Pemphigoid with unique IgA deposit].

Pan Afr Med J 2017 13;26:136. Epub 2017 Mar 13.

Université de Sousse, Tunisie.

Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Read More

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June 2017
5 Reads

Conjunctival Squamous Cell Neoplasia Associated With Ocular Cicatricial Pemphigoid.

Ophthalmic Plast Reconstr Surg 2017 Nov/Dec;33(6):e157-e160

*Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, †Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, ‡David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, §Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, and ‖Cornea and Refractive Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. Read More

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November 2017
9 Reads

Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease.

J Invest Dermatol 2017 Aug 26;137(8):1709-1718. Epub 2017 Apr 26.

Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany; Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

Mucous membrane pemphigoid is an autoantibody-mediated disease predominantly affecting the oral cavity, pharynx, and conjunctiva. Conjunctival lesions may lead to impaired vision and, finally, blindness. About 25% of mucous membrane pemphigoid patients generate autoantibodies against the α3 chain of laminin 332 (LAMα3), a structural protein of epidermal/epithelial basement membranes. Read More

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August 2017
12 Reads

Oesophageal involvement in 26 consecutive patients with mucous membrane pemphigoid.

Br J Dermatol 2017 Oct 1;177(4):1074-1085. Epub 2017 Oct 1.

Department of Dermatology and Referral Center for Auto-Immune Bullous Diseases, Avicenne Hospital, APHP, University Paris 13, 93009, Bobigny, France.

Background: Oesophageal involvement of mucous membrane pemphigoid (MMP) has not yet been thoroughly described.

Objectives: To characterize systematically the endoscopic lesions of a series of patients with oesophageal symptoms seen at a referral centre for autoimmune bullous diseases.

Methods: Clinical, endoscopic and immunological findings of consecutively referred patients with MMP with oesophageal involvement, systemic and endoscopic treatments, and follow-up are described. Read More

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October 2017
2 Reads

Characterization of Corneal Involvement in Eyes With Mucous Membrane Pemphigoid by In Vivo Confocal Microscopy.

Cornea 2017 Aug;36(8):933-941

*Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA; and †Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Purpose: To describe the morphological features of the corneal epithelial layers, subbasal nerve plexus, stroma, and endothelium in patients with mucous membrane pemphigoid (MMP) as shown by in vivo confocal microscopy (IVCM).

Methods: Central corneal images were captured from 10 healthy age-matched control eyes and 30 eyes with clinically diagnosed MMP by in vivo laser scanning confocal microscopy (HRT III RCM). Morphological changes of the corneal epithelial layers, stroma, and endothelium, characteristics of corneal nerves, and presence of inflammatory dendritic cells (DCs) were evaluated. Read More

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August 2017
2 Reads

Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.

Oral Health Prev Dent 2017;15(2):177-182

Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

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November 2017
3 Reads

Mucous Membrane Pemphigoid Causing Central Airway Obstruction.

J Bronchology Interv Pulmonol 2017 Oct;24(4):334-338

*Department of Pulmonary, Critical Care & Sleep Disorders Medicine, University of Louisville, Louisville, KY Departments of †Internal Medicine §Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque ‡CHRISTUS St. Vincent Regional Medical Center, Santa Fe, NM.

Mucous membrane pemphigoid (MMP) is a rare variant of the skin disease pemphigoid, which predominantly involves the mucous membranes. This rare autoimmune disease that infrequently affects the respiratory tract is characterized by subepithelial blister formation that may result in scarring. Immunopathologic examination of mucous membranes reveals the deposition of immunoglobulins and complement within the subepithelial basement membrane. Read More

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October 2017
3 Reads

[Dermatoses and herpes superinfection: A retrospective study of 34 cases].

Ann Dermatol Venereol 2017 Mar 24;144(3):176-181. Epub 2017 Feb 24.

Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France. Electronic address:

Background: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated.

Aim: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department.

Patients And Methods: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis. Read More

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March 2017
2 Reads

Describing the gingival involvement in a sample of 182 Italian predominantly oral mucous membrane pemphigoid patients: A retrospective series.

Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e149-e152. Epub 2017 Mar 1.

Department of Surgical Sciences; CIR - Dental School, School of Medicine, University of Turin, Via Nizza 230, 10126 Turin, Italy,

Background: The oral cavity has been frequently described as the only site of involvement or as the first manifestation of mucous membrane pemphigoid (MMP), being the gingival tissues often involved, but usually this has been effusively detailed in limited case series. This is a retrospective evaluation of the gingival involvement in 182 Italian patients with oral MMP.

Material And Methods: The diagnosis of MMP was established by both clinical morphology and direct immunofluorescence finding. Read More

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Rituximab in the treatment of ocular cicatricial pemphigoid: a retrospective cohort study.

Graefes Arch Clin Exp Ophthalmol 2017 Jun 3;255(6):1221-1228. Epub 2017 Feb 3.

Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.

Purpose: The purpose was to evaluate the effectiveness and safety of rituximab (RTX) for the treatment of patients with aggressive ocular cicatricial pemphigoid (OCP).

Methods: A review of patient records at a tertiary referral center with biopsy confirmed OCP who presented between 2006 and 2016. Sixty-one eyes of 32 patients with symptomatic OCP who received treatment with RTX monotherapy or RTX in combination with additional immunomodulatory treatment (IMT) were evaluated. Read More

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June 2017
3 Reads

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on.

Authors:
J K Dart

Eye (Lond) 2017 Feb 20;31(2):301-332. Epub 2017 Jan 20.

Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.

This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. Read More

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February 2017
1 Read

Oral mucous membrane pemphigoid and pemphigus vulgaris-a retrospective two-center cohort study.

Oral Dis 2017 May 22;23(4):498-504. Epub 2017 Feb 22.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.

Objectives: Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement, and management outcomes were performed.

Subjects And Methods: Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included. Read More

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Periocular Amyloidosis Manifesting as Pseudopemphigoid Treated With Mitomycin C.

Cornea 2017 Apr;36(4):518-520

*Oculoplastics Department, Royal Eye Infirmary, Derriford Hospital, Plymouth, United Kingdom; and †Histopathology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

Purpose: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy.

Methods: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Read More

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April 2017
4 Reads

Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient.

J Glaucoma 2017 Apr;26(4):e146-e149

*Glaucoma Service ‡Cornea Service §Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA †Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

We describe the surgical technique of endoscopic cyclophotocoagulation in a Boston keratoprosthesis type II patient. This patient with ocular cicatricial pemphigoid had pars plana endoscopic cyclophotocoagula through wounds created in the eyelids. Read More

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April 2017
18 Reads

Oral lichenoid lesions: distinguishing the benign from the deadly.

Authors:
Susan Müller

Mod Pathol 2017 Jan;30(s1):S54-S67

Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.

Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

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January 2017
3 Reads

Mucous membrane pemphigoid with severe supraglottic stenosis and bilateral symblepharon.

Pathology 2017 Jan 30;49(1):95-97. Epub 2016 Nov 30.

Harbor-UCLA Medical Center, Los Angeles, CA, United States. Electronic address:

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January 2017
2 Reads

The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature.

J Res Med Sci 2016 14;21:37. Epub 2016 Jun 14.

Department of Dermatology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond.

Materials And Methods: PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as "cicatricial pemphigoid" or "ocular pemphigoid" or "mucous membrane pemphigoid" or "MMP" and "intravenous immunoglobulin" or "IVIg" to find all the relevant studies. Read More

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June 2016
1 Read

Mucous membrane pemphigoid involving the trachea and bronchi: an extremely rare and life-threatening presentation.

Cutis 2016 Sep;98(3):E24-E27

University of Texas Health Science Center at San Antonio, Division of Dermatology and Cutaneous Surgery, and Audie Murphy Veteran's Hospital, San Antonio, USA.

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September 2016
3 Reads

Autoimmune Blistering Diseases in the Elderly: Clinical Presentations and Management.

Drugs Aging 2016 10;33(10):711-723

Department of Dermatology, St. George Hospital, Gray St, Kogarah, Sydney, 2217, NSW, Australia.

Elderly patients are more susceptible to the development of autoimmune blistering disorders such as bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and paraneoplastic pemphigus. This article focuses on the clinical aspects of the aforementioned autoimmune blistering diseases and highlights the important factors involved in treating elderly patients. It is essential for clinicians to offer individualized treatment plans for these patients to optimize outcomes, as elderly patients often have multiple co-morbidities, polypharmacy, and suboptimal socioeconomic status that can adversely influence adequate compliance. Read More

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October 2016
7 Reads

Conjunctival Neutrophils Predict Progressive Scarring in Ocular Mucous Membrane Pemphigoid.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5457-5469

Academic Unit of Ophthalmology, Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom 2Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom.

Purpose: Ocular mucous membrane pemphigoid (OcMMP) is a rare autoimmune disorder resulting in progressive conjunctival fibrosis and ocular surface failure leading to sight loss in up to 50%. This study was designed to optimize an ocular surface sampling technique for identification of novel biomarkers associated with disease activity and/or progressive fibrosis.

Methods: Fifty-seven patients with OcMMP underwent detailed examination of conjunctival inflammation and fibrosis using fornix depth measurement. Read More

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October 2016
5 Reads

Mucous membrane pemphigoid reactive only with BP230.

J Dermatol 2016 Oct;43(10):1228-1229

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

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October 2016
13 Reads

Combined Use of Rituximab and Intravenous Immunoglobulin for Severe Autoimmune Cicatricial Conjunctivitis-An Interventional Case Series.

Cornea 2016 Dec;35(12):1611-1614

*Department of Corneal and External Eye Diseases, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom;†Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria;‡Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom; and§Department of Nephrology, Royal Liverpool University Hospital, Liverpool, United Kingdom.

Purpose: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC.

Methods: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1-3) and 1 case with linear IgA disease (patient 4) were included. Read More

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December 2016
1 Read