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    Oesophageal involvement in 26 consecutive patients with mucous membrane pemphigoid.
    Br J Dermatol 2017 Apr 18. Epub 2017 Apr 18.
    Department of Dermatology and Referral Center for Auto-Immune Bullous Diseases, Avicenne Hospital, APHP, University Paris 13, 93009, Bobigny, France.
    Background: Oesophageal involvement of mucous membrane pemphigoid (MMP) has not yet been thoroughly described.

    Objectives: This study was undertaken to systematically characterise the endoscopic lesions of a series of patients with oesophageal symptoms seen in a referral centre for autoimmune bullous diseases.

    Methods: Clinical, endoscopic and immunological findings of consecutively referred MMP patients with oesophageal involvement, systemic and endoscopic treatments and follow-up, are described. Read More

    [Dermatoses and herpes superinfection: A retrospective study of 34 cases].
    Ann Dermatol Venereol 2017 Mar 24;144(3):176-181. Epub 2017 Feb 24.
    Service de dermatologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), pavillon Tarnier, 89, rue d'Assas, 75006 Paris, France. Electronic address:
    Background: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated.

    Aim: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department.

    Patients And Methods: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis. Read More

    Rituximab in the treatment of ocular cicatricial pemphigoid: a retrospective cohort study.
    Graefes Arch Clin Exp Ophthalmol 2017 Feb 3. Epub 2017 Feb 3.
    Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA.
    Purpose: The purpose was to evaluate the effectiveness and safety of rituximab (RTX) for the treatment of patients with aggressive ocular cicatricial pemphigoid (OCP).

    Methods: A review of patient records at a tertiary referral center with biopsy confirmed OCP who presented between 2006 and 2016. Sixty-one eyes of 32 patients with symptomatic OCP who received treatment with RTX monotherapy or RTX in combination with additional immunomodulatory treatment (IMT) were evaluated. Read More

    Periocular Amyloidosis Manifesting as Pseudopemphigoid Treated With Mitomycin C.
    Cornea 2017 Apr;36(4):518-520
    *Oculoplastics Department, Royal Eye Infirmary, Derriford Hospital, Plymouth, United Kingdom; and †Histopathology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
    Purpose: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy.

    Methods: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Read More

    Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient.
    J Glaucoma 2017 Apr;26(4):e146-e149
    *Glaucoma Service ‡Cornea Service §Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA †Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    We describe the surgical technique of endoscopic cyclophotocoagulation in a Boston keratoprosthesis type II patient. This patient with ocular cicatricial pemphigoid had pars plana endoscopic cyclophotocoagula through wounds created in the eyelids. Read More

    Oral lichenoid lesions: distinguishing the benign from the deadly.
    Mod Pathol 2017 Jan;30(s1):S54-S67
    Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.
    Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

    The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature.
    J Res Med Sci 2016 14;21:37. Epub 2016 Jun 14.
    Department of Dermatology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond.

    Materials And Methods: PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as "cicatricial pemphigoid" or "ocular pemphigoid" or "mucous membrane pemphigoid" or "MMP" and "intravenous immunoglobulin" or "IVIg" to find all the relevant studies. Read More

    Combined Use of Rituximab and Intravenous Immunoglobulin for Severe Autoimmune Cicatricial Conjunctivitis-An Interventional Case Series.
    Cornea 2016 Dec;35(12):1611-1614
    *Department of Corneal and External Eye Diseases, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom;†Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria;‡Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom; and§Department of Nephrology, Royal Liverpool University Hospital, Liverpool, United Kingdom.
    Purpose: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC.

    Methods: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1-3) and 1 case with linear IgA disease (patient 4) were included. Read More

    [Involvement of mucous membranes in autoimmune bullous diseases].
    Hautarzt 2016 Oct;67(10):774-779
    Klinik und Poliklinik für Dermatologie, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
    Autoimmune bullous diseases are characterized by intraepidermal or subepidermal autoantibody deposition that leads to blisters and secondary erosion. Mucous membranes are frequently affected in pemphigus vulgaris and always involved in cicatricial and mucosal pemphigoid. Mucosal lesions are detected less frequently in patients with bullous pemphigoid or epidermolysis bullosa acquisita. Read More

    Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid.
    J Indian Soc Periodontol 2016 May-Jun;20(3):340-3
    Department of Dentistry, JIPMER, Puducherry, India.
    Desquamative gingivitis (DG) is a clinical condition in which the gingiva appears reddish, glazed, and friable with loss of superficial epithelium. DG is considered a clinical manifestation of many gingival diseases and hence not identified as a diagnosis itself. Mucous membrane pemphigoid (MMP) is an autoimmune vesiculobullous disorder of mucous membrane characterized by subepithelial bullae formation. Read More

    Conjunctival cicatrizing disease presenting with lacrimal obstruction.
    Orbit 2016 Dec 25;35(6):321-323. Epub 2016 Aug 25.
    a Orbital Plastic and Lacrimal Clinic , Royal Victorian Eye and Ear Hospital , Melbourne , Australia.
    Patients with conjunctival cicatrizing disease may develop lacrimal obstruction. Little is published on lacrimal obstruction as the presenting feature of otherwise asymptomatic cicatrizing conjunctival disease. The records of all patients presenting between 1994 and 2015 with lacrimal obstruction found to have cicatrizing conjunctival disease were reviewed. Read More

    Successful treatment with oral mizoribine in refractory ocular manifestation of mucosal pemphigus vulgaris: A unique response to different immunosuppressive drugs.
    Dermatol Ther 2016 Nov 15;29(6):442-445. Epub 2016 Jul 15.
    Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, Yatsuyamada, Koriyama, Fukushima, 963-8563, Japan.
    Pemphigus vulgaris (PV) is an acquired autoimmune disease in which the disease characteristic antibodies are directed against the desmosomal transmembrane glycoprotein, desmoglein 3 (Dsg 3), resulting in flaccid blisters and erosions of skin and mucous membrane. Among various affected sites, ocular involvement may often persist or relapse even after remission of other mucocutaneous lesions, and also represent a higher morbidity. We describe such an example case of mucosal PV, whose oral and ocular manifestations were responded specifically to oral cyclosporine and mizoribine, respectively. Read More

    Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid.
    Int J Ophthalmol 2016 18;9(5):730-7. Epub 2016 May 18.
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    Aim: To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy (IVCM) in patients with ocular cicatricial pemphigoid (OCP).

    Methods: A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. Read More

    Utility of Direct Immunofluorescence Studies in Subclassification of Autoimmune Sub-Epidermal Bullous Diseases: A 2-Year Study in a Tertiary Care Hospital.
    Turk Patoloji Derg 2016 ;32(2):91-8
    Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.
    Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More

    Boston type 1 keratoprosthesis from patient selection through postoperative management: a review for the keratoprosthetic surgeon.
    Clin Ophthalmol 2016 14;10:437-43. Epub 2016 Mar 14.
    Department of Ophthalmology and Visual Sciences, University of Illinois Eye and Ear Infirmary, Chicago, IL, USA.
    For the anterior segment surgeon, the implantation of Boston type 1 keratoprosthesis is a multistep process that begins with careful patient selection. Success depends on thorough preoperative evaluation, detailed surgical planning, and frequent postoperative follow-up. New practice patterns have emerged for each of these phases as the international experience with keratoprosthesis grows. Read More

    [Ocular Cicatricial Pemphigoid - a Retrospective Study].
    Cesk Slov Oftalmol 2016 Feb;72(1):283-92
    Introduction: Ocular cicatricial pemphigoid (OCP) is rare, severe, sight threatening autoimmune disease of the conjunctiva, which affects elderly patients, more often women.

    Aim: To evaluate the success rate of stabilisation of ocular findings in patients with OCP.

    Methods: Retrospective study of patients from Centre of Conjunctival and Corneal Diseases at Department of Ophthalmology, General University Hospital and 1st Medical Faculty of Charles University in Prague in 1992-2013 was performed. Read More

    [Epidemiology of oral diseases in a university hospital specialized consultation].
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Jun 14;117(3):136-41. Epub 2016 Mar 14.
    Service de chirurgie maxillo-faciale et de stomatologie, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille, France.
    Introduction: Oral diseases (OD) are common and affect, according to studies, 2.5 to 61.6% of general population. Read More

    Clinical and Immunological Studies of 332 Japanese Patients Tentatively Diagnosed as Anti-BP180-type Mucous Membrane Pemphigoid: A Novel BP180 C-terminal Domain Enzyme-linked Immunosorbent Assay.
    Acta Derm Venereol 2016 Aug;96(6):762-7
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan.
    Diagnosis of anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is frustrated by the difficulty of detecting BP180 reactivity. A total of 721 patients with suspected MMP, selected from a cohort of 4,698 patients with autoimmune bullous disease (AIBD), were included in this study. Of these, 332 patients were tentatively diagnosed as BP180-MMP if they showed IgG/IgA reactivity with the epidermal side of 1M NaCl-split-skin and/or positive reactivity with BP180 in at least one of our antigen detection methods. Read More

    Sera and salivary matrix metalloproteinases are elevated in patients with vesiculoerosive disease: a pilot study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 May 9;121(5):520-9. Epub 2016 Jan 9.
    Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA; Division of Oral and Maxillofacial Pathology, Department of Dental Medicine, North-Shore LIJ Health System, Manhasset, NY, USA; Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:
    Background: Oral vesiculoerosive (VE) diseases, such as lichen planus and mucous membrane pemphigoid, are immune-mediated pathoses. Matrix metalloproteinase (MMP)-2 and MMP-9 are elevated in oral lesional biopsy specimens of patients with VE disease. However, the systemic levels and activity of MMP-2 and MMP-9 in this patient population are poorly understood. Read More

    Rituximab combined with conventional therapy versus conventional therapy alone for the treatment of mucous membrane pemphigoid (MMP).
    J Am Acad Dermatol 2016 May 28;74(5):835-40. Epub 2016 Feb 28.
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:
    Background: The use of rituximab for refractory autoimmune blistering diseases is increasing. Data related to rituximab for the treatment of mucous membrane pemphigoid (MMP) are limited.

    Objective: We sought to compare the efficacy of adding rituximab with traditional immunosuppressive therapies in the treatment of MMP. Read More

    Autoimmune bullous diseases with skin and eye involvement: Cicatricial pemphigoid, pemphigus vulgaris, and pemphigus paraneoplastica.
    Clin Dermatol 2016 Mar-Apr;34(2):205-13. Epub 2015 Dec 19.
    Department of Medicine (Dermatology), Vanderbilt University School of Medicine, Nashville, TN; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.
    Autoimmune blistering diseases are a heterogeneous group of disorders that mostly affect the skin and mucous membranes. Occasionally, other organ systems may be involved, depending on the unique pathophysiology of each disease. Cicatricial pemphigoid, pemphigus vulgaris, and paraneoplastic pemphigus are distinct entities, but all have the potential to have cutaneous and ocular involvement. Read More

    Update on ocular cicatricial pemphigoid and emerging treatments.
    Surv Ophthalmol 2016 May-Jun;61(3):314-7. Epub 2015 Dec 19.
    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, USA; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
    Mucous membrane pemphigoid is a systemic disorder that primarily affects mucous membranes. When localized to the conjunctiva, it is known as ocular cicatricial pemphigoid, a potentially blinding disease. Ocular cicatricial pemphigoid is an indication for systemic immunosuppressive treatment to achieve adequate remission. Read More

    Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid.
    Br J Dermatol 2016 May 7;174(5):1022-9. Epub 2016 Mar 7.
    Mucosal and Salivary Biology Division, Dental Institute, King's College London, London, U.K.
    Background: Mucous membrane pemphigoid (MMP) is an uncommon mucocutaneous immunobullous disorder. Use of saliva for diagnosis by enzyme-linked immunosorbent assay (ELISA) using the noncollagenous (NC) domain 16a of bullous pemphigoid antigen II (BP180) is not well described.

    Objective: To establish whether whole or parotid saliva is a suitable alternative to serum for diagnosis of MMP. Read More

    IgM ocular cicatricial pemphigoid: a unique insight into the immune system.
    Dermatol Online J 2015 Oct 16;21(10). Epub 2015 Oct 16.
    University of Illinois College of Medicine.
    A 42-year-old man with ocular erythema and scarring had a conjunctival biopsy revealing depostion of IgM and C3 without IgG at the epithelial basement membrane zone.  Treatment with doxycyline, dapsone, and mycophenolate mofetil was unsuccessful and treatment with rituximab has led to partial remission of the conjunctival inflammation. He has undergone 4 cycles of rituximab treatment at intervals of 12 to 18 months. Read More

    Autoantibody Profile of a Cohort of 78 Italian Patients with Mucous Membrane Pemphigoid: Correlation Between Reactivity Profile and Clinical Involvement.
    Acta Derm Venereol 2016 Aug;96(6):768-73
    Department of Dermatology, IRCCS AOU san martino-IST, DISSAL, Sezione di Dermatologia , University of Genoa, IT-16100 Genova, Italy.
    Direct diagnosis of mucous membrane pemphigoid (MMP) is not easy. Circulating autoantibodies targeting bullous pemphigoid antigens of 180 kDa and 230 kDa (BP180 and BP230), α6β4 integrin, laminin 332 and type VII collagen (Col VII) are not always present. The aims of this study were to characterize the humoral immune response of a cohort of Italian patients with MMP, its association with clinical involvement and severity, and to design an algorithm for efficient serological diagnosis. Read More

    Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid.
    J Dtsch Dermatol Ges 2015 Dec;13(12):1268-74
    Center for Ophthalmology, Eberhard- Karls-University, Tübingen, Germany.
    Background And Objectives: The objective was to determine the diagnostic value of direct immunofluorescence (DIF) in ocular mucous membrane pemphigoid (ocular MMP), taking into account immunofluorescence patterns and biopsy sites.

    Patients And Methods: DIF results and medical records of 54 patients with a suspected diagnosis of ocular MMP were reviewed.

    Results: There was an overall prevalence of ocular MMP in 70. Read More

    NGF Modulates trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP).
    PLoS One 2015 16;10(11):e0142737. Epub 2015 Nov 16.
    Department of Ophthalmology, University Campus Bio-Medico, Rome, Italy.
    Objective: In a previous study, we reported the upregulation of Nerve Growth Factor (NGF) and trkANGFR expression in Ocular Cicatricial Pemphigoid (OCP), an inflammatory and remodeling eye disease. Herein, we hypothesize a potential NGF-driven mechanism on fibroblasts (FBs) during OCP remodeling events. To verify, human derived OCP-FBs were isolated and characterized either at baseline or after NGF exposure. Read More

    Esophageal Cicatricial Pemphigoid as an Isolated Involvement Treated with Mycophenolate Mofetil.
    Case Rep Gastrointest Med 2015 18;2015:620374. Epub 2015 Oct 18.
    Gastroenterology Department, Hospital Infanta Cristina, Avenida 9 de Junio, No. 2, 28981 Parla, Madrid, Spain.
    Cicatricial pemphigoid (CP) is a rare blistering autoimmune disease. Esophageal involvement occurs in widespread disease and rarely appears as the only affected organ. We report a 67-year-old Caucasian female with esophageal dysphagia and weight loss. Read More

    A systematic review with pooled analysis of clinical presentation and immunodiagnostic testing in mucous membrane pemphigoid: association of anti-laminin-332 IgG with oropharyngeal involvement and the usefulness of ELISA.
    J Eur Acad Dermatol Venereol 2016 Jan 7;30(1):72-7. Epub 2015 Oct 7.
    Department of Dermatology and Allergology, Phillipps University, Marburg, Germany.
    Background: Mucous membrane pemphigoid (MMP) is characterized by subepithelial blistering due to IgG autoantibodies targeting various components of the dermal-epidermal basement membrane zone. Immunodiagnostics play an important role in making a precise diagnosis. Measures of test sensitivity and specificity, however, typically come from studies in diseases such as bullous pemphigoid, where the exact antigenic site may not be the same. Read More


    Protective effect of soft contact lenses after Boston keratoprosthesis.
    Br J Ophthalmol 2016 Apr 14;100(4):549-52. Epub 2015 Aug 14.
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose: To evaluate associations between preoperative diagnosis, soft contact lens (SCL) retention and complications.

    Methods: A retrospective chart review was conducted of 92 adult patients (103 eyes) who received a Boston keratoprosthesis type I at the Massachusetts's Eye and Ear Infirmary or the Flaum Eye Institute. Records were reviewed for preoperative diagnosis, SCL retention and subsequent complications. Read More

    Isolation and Investigation of Presumptive Murine Lacrimal Gland Stem Cells.
    Invest Ophthalmol Vis Sci 2015 Jul;56(8):4350-63
    Department of Anatomy and Cell Biology, Martin Luther University, Halle-Wittenberg, Halle (Saale), Germany 3Department of Anatomy II, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.
    Purpose: Aqueous tear deficiency due to lacrimal gland insufficiency is one of the major causes of dry eye disease. In severe cases, such as Sjogren's syndrome, Stevens-Johnson syndrome, or ocular cicatricial pemphigoid, therapy with artificial tears is often insufficient to relieve severe discomfort, prevent progressive ocular surface disease, or enable visual rehabilitation by corneal transplantation. Cell or organ generation from stem cells, resulting in tear-like secretion, presents an option as a suitable alternative treatment. Read More

    [In-vivo Confocal Microscopy for the Diagnosis of Mucous Membrane Pemphigoid].
    Klin Monbl Augenheilkd 2015 Sep 13;232(9):1077-81. Epub 2015 Jul 13.
    Augenheilkunde, Universitätsaugenklinik, Otto-von-Guericke-Universität, Magdeburg.
    Background: An early diagnosis is crucial for the outcome of mucous membrane pemphigoid (MMP). The sensitivity of the so-called diagnostic gold standard, direct and indirect immune fluorescence (DIF/IIF) ranges from 30 to 80 %, and is thus lower than desirable. Moreover, conjunctival biopsy, mandatory in most cases, entails the risks of exacerbation. Read More

    Linear IgA dermatosis adult variant with oral manifestation: A rare case report.
    J Oral Maxillofac Pathol 2015 Jan-Apr;19(1):83-7
    Department of Oral Pathology and Microbiology, Sree Mookambika Institute of Dental Sciences, Padanilam, Kulasekharam, Tamil Nadu, India.
    Linear immunoglobulin A (IgA) dermatosis (LAD) is a rare autoimmune disorder that presents as a vesiculo-bullous lesion with cutaneous manifestations, but rare oral mucosal involvement. Here we discuss a case of a vesiculobullous lesion with severe oral and ocular mucosal involvement mimicking pemphigoid with histopathological evidence of subepithelial blisters. Direct immunofluorescence (DIF) confirmed the lesion as LAD of adult variant, although with atypical clinical features. Read More

    Sealing of the gap between the conjunctiva and tenon capsule to improve symblepharon surgery.
    Am J Ophthalmol 2015 Sep 17;160(3):438-446.e1. Epub 2015 Jun 17.
    Ocular Surface Center and Ocular Surface Research & Education Foundation, Miami, Florida. Electronic address:
    Purpose: To report the surgical outcome of "sealing the gap" in treating symblepharon caused by various etiologies other than recurrent pterygium.

    Design: Retrospective, interventional case series.

    Methods: Sixteen eyes of 14 patients with pathogenic symblepharon were consecutively operated by conjunctival recession, sealing the gap between recessed conjunctiva and Tenon capsule with a running 9-0 nylon suture, and covering of the bare sclera with amniotic membrane. Read More

    Rituximab preserves vision in ocular mucous membrane pemphigoid.
    Expert Opin Biol Ther 2015 Jul 12;15(7):927-33. Epub 2015 May 12.
    Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum , Ophthalmology , Augustenburger Platz 1, Berlin, 13353 , Germany
    Objective: To study the effectiveness and safety of anti-CD20 B-cell antibody rituximab (RTX) in the treatment of ocular mucous membrane pemphigoid (MMP).

    Methods: Retrospective analysis of six MMP patients receiving RTX with or without concomitant immunosuppression. RTX was administered as a high dose regimen (1000 mg/infusion, day 0 and day 14/cycle). Read More

    World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Aug 11;120(2):161-71.e20. Epub 2015 Mar 11.
    Associate Professor, Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, New York City, New York, USA. Electronic address:
    Objective: To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP).

    Study Design: We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. Read More

    Oral lichen planus pemphigoides: a series of four cases.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul 13;120(1):58-68. Epub 2015 Apr 13.
    Center for Oral Pathology, StrataDx, Lexington, MA, USA; Associate Professor of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA; Chief of Clinical Affairs, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
    Objective: Lichen planus pemphigoides (LPP), which is a rare autoimmune blistering mucocutaneous disease of the pemphigoid family of diseases, is characterized by the development of vesiculobullous lesions on or adjacent to the areas of lichen planus (LP). LPP primarily affects the skin, and oral involvement alone is rare. The objective of this case series was to report four new cases of oral LPP. Read More

    Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab.
    JAMA Dermatol 2015 Jun;151(6):646-50
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento.
    Importance: Immunobullous diseases mediated by IgA are often difficult to manage, but to date no mechanism has been proposed. Rituximab is an anti-CD20 monoclonal antibody that has demonstrated good efficacy in the treatment of refractory mucous membrane pemphigoid. However, not all cases of mucous membrane pemphigoid respond to rituximab. Read More

    Characteristics of patients with ocular cicatricial pemphigoid referred to major tertiary hospital.
    Can J Ophthalmol 2015 Apr;50(2):137-42
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto Western Hospital, Toronto, Ont.
    Objective: To evaluate the demographic and clinical characteristics of patients referred to a tertiary care hospital cornea clinic for ocular cicatricial pemphigoid (OCP) assessment.

    Design: Retrospective, nonrandomized, consecutive case series.

    Participants: Thirty three patients with OCP who were treated at the corneal clinic of Toronto Western Hospital from 2003 to 2012. Read More

    Long-term rebamipide and diquafosol in two cases of immune-mediated dry eye.
    Optom Vis Sci 2015 Apr;92(4 Suppl 1):S25-32
    *MD †PhD Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan (all authors).
    Purpose: Two new drugs with mucin-inducing and secretion-promotive effects, rebamipide and diquafosol, were recently approved as topical dry-eye treatments. We report two cases in which the long-term use of mucin-inducing eye drops improved chronic ocular graft-versus-host disease (cGVHD)-related dry eye and ocular cicatricial pemphigoid (OCP)-like disease.

    Case Reports: Case 1. Read More

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