1,656 results match your criteria Cicatricial Pemphigoid


Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.

Autoimmun Rev 2019 Apr 7;18(4):349-358. Epub 2019 Feb 7.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy. Electronic address:

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.02.005DOI Listing
April 2019
19 Reads

A conjunctival-sparing surgical technique for lower eyelid cicatricial entropion repair in ocular cicatricial pemphigoid.

Orbit 2019 Feb 7:1-8. Epub 2019 Feb 7.

b Ophthalmic Plastic Surgery Service, Department of Ophthalmology , Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston , MA , USA.

Purpose: To present five cases of lower eyelid cicatricial entropion secondary to ocular cicatricial pemphigoid (OCP) successfully repaired with a conjunctival-sparing surgical technique.

Methods: The records of one surgeon (SKF) were reviewed to identify patients with lower eyelid cicatricial entropion secondary to OCP who underwent repair with a conjunctival-sparing technique between September 1, 2016 and October 18, 2017. The medical records were reviewed and extracted data included: age, gender, past medical history, current medical and OCP status, clinical examination, details of entropion repair surgery, and outcome. Read More

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http://dx.doi.org/10.1080/01676830.2019.1573434DOI Listing
February 2019

Brunsting-Perry Type Pemphigoid Causing Secondary Cicatricial Alopecia in 2 Patients.

Skin Appendage Disord 2018 Oct 20;4(4):308-311. Epub 2018 Apr 20.

Universidade Federal Fluminense, Niterói, Brazil.

Brunsting-Perry type pemphigoid (BPP) is a rare subepidermal blistering disease and a cause of secondary cicatricial alopecia. It was originally described by Brunsting and Perry in 1957 as a rare variant of cicatricial pemphigoid, characterized by bullous lesions limited to the head, neck, scalp, and upper trunk with mild or no mucosal involvement. We report 2 cases of BPP cicatricial alopecia with histopathology of subepidermal blister formation, different clinical presentation, and different salt-split test results. Read More

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http://dx.doi.org/10.1159/000485570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219224PMC
October 2018
26 Reads

Oesophageal cicatricial pemphigoid.

Gastroenterol Hepatol 2018 Oct 3. Epub 2018 Oct 3.

Servicio de Aparato Digestivo, Hospital Universitario San Cecilio, Granada, España.

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http://dx.doi.org/10.1016/j.gastrohep.2018.08.007DOI Listing
October 2018

Coexistence of mucous membrane pemphigoid, vitiligo, and hypothyroidism: A second report of a new multiple autoimmune syndrome.

Dermatol Ther 2018 11 26;31(6):e12717. Epub 2018 Sep 26.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Tehran, Iran.

Mucous membrane pemphigoid (MMP) is a rare immunobullous disease affecting the mucous membrane and skin. An association of MMP with other autoimmune disease is uncommon. Multiple autoimmune syndrome (MAS) is a subclass of autoimmune disorders with a coexistence of three or more autoimmune disorder in a single patient. Read More

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http://dx.doi.org/10.1111/dth.12717DOI Listing
November 2018
19 Reads

Efficacy and adverse reactions of methotrexate in the treatment of ocular cicatricial pemphigoid: A case series study.

Medicine (Baltimore) 2018 Sep;97(38):e12338

Department of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University.

The application of methotrexate (MTX) in the treatment of autoimmune diseases has been gradually increasing, but reports of MTX treatment for advanced ocular cicatricial pemphigoid (OCP) are extremely rare. This study investigated the efficacy and adverse reactions of low-dose MTX in patients with OCP.This was a retrospective, noncontrolled, case series study. Read More

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http://dx.doi.org/10.1097/MD.0000000000012338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160102PMC
September 2018
4 Reads

Ocular cicatricial pemphigoid.

Curr Opin Ophthalmol 2018 Nov;29(6):543-551

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California, USA.

Purpose Of Review: This review offers recommendations for monitoring disease status in ocular cicatricial pemphigoid as well therapeutic options including local and systemic therapies.

Recent Findings: A negative biopsy on direct immunofluorescence does not preclude a diagnosis of OCP. If a patient's cicatrization is active and/or progressive, systemic immunosuppression should be commenced. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000517DOI Listing
November 2018
5 Reads

Atypical case of mucous membrane pemphigoid in a 26-year-old man.

BMJ Case Rep 2018 Sep 12;2018. Epub 2018 Sep 12.

Department of Ophthalmology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.

A 26-year-old Caucasian man with no previous history of chemical injury presenting with an inability to open his right eye was investigated for mucous membrane pemphigoid and treated. Examination was notable for symblepharon of the right eye and impetigo-like lesions on the face and neck. A biopsy with immunohistochemical analysis was significant for linear deposits of C3 and immunoglobulin G at the level of the epithelial basement membrane, confirming the diagnosis of mucous membrane pemphigoid. Read More

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http://dx.doi.org/10.1136/bcr-2018-225872DOI Listing
September 2018
5 Reads

Painful Oral Lesions.

Dent Clin North Am 2018 10 14;62(4):597-609. Epub 2018 Aug 14.

Naval Postgraduate Dental School, Bethesda, MD, USA. Electronic address:

Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. Read More

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http://dx.doi.org/10.1016/j.cden.2018.06.002DOI Listing
October 2018
14 Reads

Corneal epithelial stem cells for corneal injury.

Expert Opin Biol Ther 2018 09 9;18(9):997-1003. Epub 2018 Aug 9.

c Reproductive Medicine, Developmental Biology & Reproduction , University Hospital & School of Medicine, Picardie University Jules Verne , Amiens , France.

Introduction: Ocular surface diseases with limbal insufficiency represent a therapeutic challenge for restoring vision. This corneal deficiency includes both classical ocular diseases (as chemical burns) and rare ocular diseases (as congenital aniridia and ocular cicatricial pemphigoid). Areas covered: Our understanding of limbal epithelial stem cells (LESCs) has increased the potential for treatment options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2018.1
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http://dx.doi.org/10.1080/14712598.2018.1508443DOI Listing
September 2018
10 Reads

Laryngoceles with airway compromise complicating mucous membrane pemphigoid.

BMJ Case Rep 2018 Jul 18;2018. Epub 2018 Jul 18.

Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Mucous membrane pemphigoid (MMP) encompasses a group of autoantibody-mediated, subepithelial blistering diseases, which primarily affect mucosal surfaces including oral, ocular, skin, genital, nasopharyngeal and oesophageal sites. We present a first description of laryngoceles as a manifestation of mucous membrane pemphigoid resulting in dynamic airway closure. Mucosal injury at other sites had previously resulted in pathergy and localised cicatrisation. Read More

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http://dx.doi.org/10.1136/bcr-2018-225316DOI Listing
July 2018
2 Reads

Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid.

Orphanet J Rare Dis 2018 07 6;13(1):111. Epub 2018 Jul 6.

Department of Dermatology, University Medical Center Freiburg, Hauptstrasse 7, 79104, Freiburg, Germany.

Background: Mucous membrane pemphigoid is a group of chronic subepithelial autoimmune blistering diseases that mainly affect mucous membranes. Laminin 332-specific autoantibodies are present in approximately 1/3 of the patients, being associated with an increased risk of malignancy. Because of the severe complications, an early recognition of the disease allowing a timely therapy is essential. Read More

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http://dx.doi.org/10.1186/s13023-018-0855-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035451PMC
July 2018
28 Reads
3.360 Impact Factor

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.

J Immunol Res 2018 27;2018:6061825. Epub 2018 May 27.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, Italy.

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. Read More

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https://www.hindawi.com/journals/jir/2018/6061825/
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http://dx.doi.org/10.1155/2018/6061825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994274PMC
October 2018
6 Reads

Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature.

Int Wound J 2018 Dec 29;15(6):909-913. Epub 2018 Jun 29.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.

Mucous membrane pemphigoid (MMP) is a group of chronic autoimmune sub-epithelial blistering disorders, which mostly affect the oral mucosa and the conjunctiva. MMP is very diverse in terms of both the clinical and immunological features (IgG and IgA autoantibodies may react with different antigens). MMP can be induced by infections and medication, including ophthalmologic medication, which may lead to the development of eye lesions. Read More

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http://dx.doi.org/10.1111/iwj.12943DOI Listing
December 2018
9 Reads

A case of antiepiligrin cicatricial pemphigoid with extensive cutaneous erosions mimicking pemphigus vulgaris.

BMJ Case Rep 2018 Jun 21;2018. Epub 2018 Jun 21.

Department of Dermatology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Cicatricial pemphigoid (CP) is a chronic, autoimmune, subepidermal blistering disease with predominant mucosal involvement. In this article, we report a young patient with mucosal and extensive cutaneous involvement in the form of large erosions mimicking those of pemphigus vulgaris thus leading to diagnostic dilemma. We were unable to find any other previous reports with such extensive cutaneous erosions mimicking those of pemphigus vulgaris. Read More

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http://dx.doi.org/10.1136/bcr-2018-225446DOI Listing
June 2018
13 Reads

Adrenocorticotropic hormone analogue as novel treatment regimen in ocular cicatricial pemphigoid.

Am J Ophthalmol Case Rep 2018 Jun 20;10:264-267. Epub 2018 Mar 20.

Metropolitan Eye Research and Surgery Institute, Palisades Park, NJ, USA.

Purpose: To report the clinical outcome of a patient with ocular cicatricial pemphigoid, treated with adrenocorticotropic hormone gel.

Observations: A 75-year-old female with a biopsy proven ocular cicatricial pemphigoid (OCP) presented with bilateral conjunctival inflammation, fornix shortening, subepithelial fibrosis and corneal scarring. The patient was previously treated with topical steroids, topical cyclosporine and lubricating drops, and had undergone several amniotic membrane transplants due to recurrent corneal erosions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936173029
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http://dx.doi.org/10.1016/j.ajoc.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956726PMC
June 2018
29 Reads

Immunohistochemical diagnosis of mucous membrane pemphigoid.

J Oral Pathol Med 2018 Jul 30;47(6):613-619. Epub 2018 May 30.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Background: Mucous membrane pemphigoid (MMP) is an autoimmune subepithelial blistering disease with predominant involvement of mucosal surfaces. It is usually diagnosed by direct immunofluorescence microscopy of frozen biopsies, demonstrating linear deposits of complement, IgG or IgA along the basement membrane. The aim of this study was to investigate the utility of immunohistochemistry on formalin-fixed, paraffin-embedded tissue biopsies for the diagnosis of MMP and to compare its sensitivity to that of direct immunofluorescence microscopy. Read More

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http://dx.doi.org/10.1111/jop.12732DOI Listing
July 2018
1 Read

HLA alleles in British Caucasians with mucous membrane pemphigoid.

Eye (Lond) 2018 09 10;32(9):1540-1541. Epub 2018 May 10.

The Lübeck Institut of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/s41433-018-0092-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137197PMC
September 2018
1 Read

Brunsting-Perry pemphigoid: a case with antigen identification.

Int J Dermatol 2018 07 23;57(7):e41-e43. Epub 2018 Apr 23.

University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/ijd.14019DOI Listing
July 2018
4 Reads

Desquamative gingivitis: Diagnosis and treatment.

J Am Acad Dermatol 2018 05;78(5):851-861

Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Dermatology, Weill Cornell Medical College, New York, New York.

Desquamative gingivitis is a clinical finding with several potential etiologies, and therefore histologic examination should be performed to confirm the diagnosis before the implementation of systemic therapy. The best methods for obtaining a mucosal biopsy specimen are discussed to aid the dermatologist in approaching these patients, and indications for additional testing, such as immunofluorescence studies, are reviewed. Desquamative gingivitis is uncommon, and there are no systematic guidelines to assist the physician in treatment, producing a practice gap in management. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.04.1140DOI Listing
May 2018
12 Reads

Desquamative gingivitis: Clinical findings and diseases.

J Am Acad Dermatol 2018 05;78(5):839-848

Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Dermatology, Weill Cornell Medical College, New York, New York.

Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.05.056DOI Listing
May 2018
5 Reads

Incidence and Clinical Characteristics of Ocular Involvement in Mucous Membrane Pemphigoid.

Ocul Immunol Inflamm 2018 Apr 19:1-5. Epub 2018 Apr 19.

a Wilmer Eye Institute , Johns Hopkins University School of Medicine , Baltimore , Maryland , USA.

Purpose: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement.

Methods: Retrospective chart review of 162 biopsy-proven MMP patients.

Results: At presentation, 109 of 162 MMP patients (67. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1455879DOI Listing
April 2018
7 Reads

Structured Diagnostic Approach and Risk Assessment in Mucous Membrane Pemphigoid with Oesophageal Involvement.

Acta Derm Venereol 2018 Jul;98(7):660-666

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, DE-97080 Würzburg, Germany.

Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid. Read More

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http://dx.doi.org/10.2340/00015555-2938DOI Listing
July 2018
3 Reads

[Autologous serum tears: Long-term treatment in dry eye syndrome].

J Fr Ophtalmol 2018 Mar 27;41(3):246-254. Epub 2018 Mar 27.

Service d'ophtalmologie, CHU de Hôpital La Timone, 264, rue Saint-Pierre, 13385 Marseille, France.

Introduction: Dry eye disease is a multifactorial pathology of the ocular surface. The high incidence of this pathology, as well as its significant impact on quality of life and vision and its financial cost, makes it a real public health problem. While the treatment of mild cases is generally simple and effective, treatment of severe forms is often disappointing. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.11.008DOI Listing
March 2018
37 Reads

A case with corneal perforation due to bacterial concretion derived from lacrimal canaliculitis.

Am J Ophthalmol Case Rep 2018 Mar 12;9:116-118. Epub 2018 Jan 12.

Department of Ophthalmology, Saitama Medical University, Saitama, Japan.

Purpose: To report a case with corneal perforation, presumably due to ocular cicatricial pemphigoid (OCP) and bacterial concretion derived from lacrimal canaliculitis.

Observations: A patient with OCP demonstrated adherence of concretion to the cornea of her right eye. She also demonstrated canaliculitis in this eye. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861392PMC
March 2018
3 Reads

Blistering diseases in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):231-238. Epub 2017 Oct 3.

Department of Dermatovenereology, University Hospital Center Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address:

Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.014DOI Listing
September 2018
13 Reads

Effectiveness and Safety of Rituximab in Recalcitrant Pemphigoid Diseases.

Front Immunol 2018 19;9:248. Epub 2018 Feb 19.

Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Introduction: Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited.

Objective: To assess the effectiveness and safety of RTX in pemphigoid diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827539PMC
March 2019
8 Reads

Management of Ocular Cicatricial Pemphigoid with Intravenous Immunoglobulin Monotherapy.

Ocul Immunol Inflamm 2018 Mar 8:1-7. Epub 2018 Mar 8.

a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA.

Purpose: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP).

Methods: A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. Read More

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http://dx.doi.org/10.1080/09273948.2018.1433302DOI Listing
March 2018
5 Reads

Vulval lichen planus-lichen sclerosus overlap.

Int J STD AIDS 2018 09 28;29(10):1017-1023. Epub 2018 Feb 28.

2 School of Medicine, Deakin University, Geelong, Australia.

Vulval lichen planus-lichen sclerosus overlap is an emerging observation. Few clinical reports exist with no reviews of literature. We present a focused update of this phenomenon and discuss a clinical case. Read More

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http://dx.doi.org/10.1177/0956462418758777DOI Listing
September 2018
11 Reads

Oral mucous membrane pemphigoid: A clinical study of 100 low-risk cases.

Oral Dis 2018 Mar;24(1-2):132-134

Universidad Europea de Valencia, Valencia, Spain.

Objective: To analyze the severity of the oral lesions in low-risk oral mucous membrane pemphigoid (OMMP) measured according to the size of the bullous areas and the number of simultaneously affected oral locations.

Material And Methods: A total of 100 cases of low-risk OMMP were studied. The symptoms and location of OMMP in the oral cavity were analyzed. Read More

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http://dx.doi.org/10.1111/odi.12744DOI Listing
March 2018
2 Reads

In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign.

J Dermatol 2018 May 26;45(5):603-605. Epub 2018 Feb 26.

Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-year-old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. Read More

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http://dx.doi.org/10.1111/1346-8138.14267DOI Listing
May 2018
3 Reads

Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross-sectional study.

Oral Dis 2018 Jul 16;24(5):802-808. Epub 2018 Apr 16.

Department of Oral and Maxillofacial Surgery, Oral Medicine, and Periodontics, School of Dentistry, The University of Jordan, Amman, Jordan.

Objectives: To describe the natural history and factors influencing diagnostic delays among patients with autoimmune blistering diseases of the mouth.

Materials And Methods: In this cross-sectional study, 27 newly diagnosed patients were interviewed, and professional and patient delays were calculated. Disease extent and severity scores were determined using Saraswat scoring system. Read More

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http://dx.doi.org/10.1111/odi.12839DOI Listing
July 2018
3 Reads

[Mucosal pemphigoid].

Tidsskr Nor Laegeforen 2018 01 22;138(2). Epub 2018 Jan 22.

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http://dx.doi.org/10.4045/tidsskr.17.0557DOI Listing
January 2018

Vitreoretinal Complications and Outcomes in 92 Eyes Undergoing Surgery for Modified Osteo-Odonto-Keratoprosthesis: A 10-Year Review.

Ophthalmology 2018 Jun 17;125(6):832-841. Epub 2018 Jan 17.

CJ Shah Cornea Services and Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Chennai, India.

Purpose: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery.

Design: Retrospective case series.

Participants: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420173238
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http://dx.doi.org/10.1016/j.ophtha.2017.12.003DOI Listing
June 2018
16 Reads

Atopy in Patients With Ocular Cicatricial Pemphigoid.

Cornea 2018 Apr;37(4):436-441

Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA.

Purpose: To evaluate the presence of atopy in patients with ocular cicatricial pemphigoid (OCP).

Method: Patient encounters between August 2005 and November 2016 at the Massachusetts Eye Research and Surgery Institute (MERSI) were searched to identify those with biopsy-proven OCP who had concurrent evidence of atopy.

Results: There were 230 patients with biopsy-proven OCP. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001477DOI Listing
April 2018
6 Reads

An unusual presentation of ocular rosacea.

Arq Bras Oftalmol 2017 Nov-Dec;80(6):396-398

Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.

Rosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Read More

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http://dx.doi.org/10.5935/0004-2749.20170097DOI Listing
October 2018
9 Reads

[Mucous membrane pemphigoid].

Hautarzt 2018 Jan;69(1):67-83

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23558, Lübeck, Deutschland.

Mucous membrane pemphigoid (MMP) is a pemphigoid disease defined by the presence of autoantibodies against the dermal-epidermal junction and predominant involvement of mucous membranes. Diagnosis is made by the clinical presentation and linear deposits of IgG and/or IgA and/or C3 at the dermal-epidermal junction by direct immunofluorescence microscopy of a perilesional biopsy. Circulating autoantibodies can be detected in most patients by indirect immunofluorescence microscopy on salt-split human skin as well as ELISA and immunoblotting with recombinant and cell-derived target antigens. Read More

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http://dx.doi.org/10.1007/s00105-017-4089-yDOI Listing
January 2018
5 Reads

Cataract surgery in ocular surface diseases: clinical challenges and outcomes.

Curr Opin Ophthalmol 2018 Jan;29(1):81-87

Cornea service, Nethradhama Eye Hospital, Bangalore, Karnataka, India.

Purpose Of Review: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000441DOI Listing
January 2018
6 Reads

Oral Manifestation in Patients diagnosed with Dermatological Diseases.

J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.

Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

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December 2017
5 Reads

Genomewide association study identifies GALC as susceptibility gene for mucous membrane pemphigoid.

Exp Dermatol 2017 12;26(12):1214-1220

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Mucous membrane pemphigoid (MMP) is a rare, chronic and often aggressive subepidermal autoimmune blistering disease potentially affecting several mucous membranes with blisters and secondary erosions and scars. The pathogenesis of MMP is poorly understood, and the contribution of genetic predispositions, other than HLA class II allele variants to MMP, is unknown. The objective of this study is to identify susceptibility genes for MMP in a British cohort of MMP patients. Read More

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http://dx.doi.org/10.1111/exd.13464DOI Listing
December 2017
8 Reads

A case of mucous membrane pemphigoid with IgG antibodies against the β3 and γ2 subunits of laminin-332, and the C-terminal domain of BP180.

Int J Dermatol 2018 Jan 11;57(1):86-88. Epub 2017 Nov 11.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/ijd.13829DOI Listing
January 2018
4 Reads

Efficacy of intravenous immunoglobulins for the treatment of mucous membrane pemphigoid-like epidermolysis bullosa acquisita.

Eur J Dermatol 2017 10;27(5):563-564

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.

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http://dx.doi.org/10.1684/ejd.2017.3118DOI Listing
October 2017
8 Reads

Long-term remission of ocular cicatricial pemphigoid off immunomodulatory therapy.

Eur J Ophthalmol 2018 Mar;28(2):157-162

1 Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA - USA.

Purpose: To evaluate whether long-term remission of ocular cicatricial pemphigoid (OCP) after withdrawal of immunomodulatory therapy (IMT) is possible.

Methods: A total of 34 of 464 presenting patients (66 eyes) with biopsy-proven OCP in long-term remission off IMT were identified after finishing a 2-year IMT regimen without active disease (2005-2015). Long-term remission off IMT for OCP was defined as patients withdrawn from IMT ≥1 year lacking clinically detectable progressive scarring according to Foster staging and subjective assessment. Read More

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http://journals.sagepub.com/doi/10.5301/ejo.5001050
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http://dx.doi.org/10.5301/ejo.5001050DOI Listing
March 2018
12 Reads

Ocular features of multiple system atrophy.

J Clin Neurosci 2018 Jan 21;47:234-239. Epub 2017 Oct 21.

Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA. Electronic address:

The aim of this paper is to gain better understanding of the ocular manifestations of multiple system atrophy (MSA), a neurodegenerative disorder rarely studied in terms of its ophthalmologic features. We performed a retrospective case series (1/1/05-12/31/14) to search for patients seen at Mayo Clinic, Rochester, MN, who had mention of MSA in the medical record and an eye examination, which yielded 285 cases. Of the 285, we identified 39 cases of true MSA. Read More

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http://dx.doi.org/10.1016/j.jocn.2017.10.028DOI Listing
January 2018
4 Reads

Endoscopic characteristics of oesophagus involvement in mucous membrane pemphigoid.

Authors:
H Yuan M Pan

Br J Dermatol 2017 10;177(4):902-903

Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1111/bjd.15804DOI Listing
October 2017
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Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets.

Cornea 2018 Jan;37(1):76-83

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency.

Methods: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COMECs were prepared in a culture system without the use of any temperature-sensitive polymers or carriers. Read More

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http://Insights.ovid.com/crossref?an=00003226-201801000-0001
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http://dx.doi.org/10.1097/ICO.0000000000001409DOI Listing
January 2018
18 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.02.019DOI Listing
November 2017
18 Reads

Pure mucinous (colloid) adenocarcinoma of the conjunctiva.

J Cutan Pathol 2018 Jan 8;45(1):78-83. Epub 2017 Nov 8.

Department of Dermatology, Section of Dermatopathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Primary mucinous carcinomas of the periorbital region are very rare and often require differential diagnosis of metastatic disease. We describe a case of pure mucinous adenocarcinoma arising in the subconjunctival stroma of the ocular fornix in a female patient with a longstanding history of bilateral ocular cicatricial pemphigoid. Histologically, the tumor was composed of predominantly goblet-like cells floating in pools of mucin separated by delicate collagenous septa. Read More

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http://dx.doi.org/10.1111/cup.13060DOI Listing
January 2018
17 Reads