1,784 results match your criteria Cicatricial Pemphigoid


Ocular cicatricial pemphigoid: Methotrexate as an initial treatment?

Reumatol Clin (Engl Ed) 2021 Jun 1. Epub 2021 Jun 1.

Servicio de Reumatología, Hospital Militar Central 601 Cirujano Mayor Doctor Cosme Argerich, Buenos Aires, Argentina.

Objective: To analyse the clinical/epidemiological data, the management and the treatments established in patients with Ocular Cicatricial Pemphigoid (OCP) in a Rheumatology Service.

Material And Methods: Review of clinical histories of patients with OCP referred by ophthalmology between 2008 and 2019.

Results: In our series of 27 patients, 67% were diagnosed and referred in the last 2 years. Read More

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An atypical presentation of plasma cell gingivitis with generalized skin lesions.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S54-S57. Epub 2021 Mar 19.

Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

This article aims to present a report of an atypical clinical presentation of a plasma cell gingivitis (PCG) case with unusual skin lesions. PCG is a rare benign inflammatory condition which can be classified into Type 4 hypersensitivity reaction. It occurs due to reaction to unknown antigen, often flavoring agents or spices found in chewing gums, toothpastes and lozenges. Read More

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Mucous membrane pemphigoid in a patient with chronic hepatitis B virus infection: A case report.

Medicine (Baltimore) 2021 May;100(20):e25955

Department of Family and Community Medicine, E-Da Hospital.

Rationale: Mucous membrane pemphigoid (MMP) is a rare, autoimmune bullous disease that affects mucosal surfaces and skin. Early and aggressive treatment initiation may be warranted due to the risks of serious complications. However, it can be challenging to make an initial diagnosis. Read More

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Tofacitinib for refractory ocular mucous membrane pemphigoid.

Am J Ophthalmol Case Rep 2021 Jun 21;22:101104. Epub 2021 Apr 21.

Division of Rheumatology, Department of Medicine, Washington University in Saint Louis, Center for Advanced Medicine, 5th floor Suite C, 4921 Parkview Place, Saint Louis, MO, 63110, USA.

Purpose: To report the successful use of tofacitinib in the treatment of refractory ocular mucous membrane pemphigoid (MMP).

Observations: Two patients with ocular MMP presented with refractory disease after failure of multiple therapies. Treatment with tofacitinib led to durable control of conjunctival inflammation within 8 weeks and no apparent progression of sub-conjunctival fibrosis. Read More

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Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases.

Br J Ophthalmol 2021 May 18. Epub 2021 May 18.

Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan

Background/aims: To investigate the long-term outcomes of cultivated oral mucosal epithelial transplantation (COMET) for fornix reconstruction in eyes with chronic cicatrising disease.

Methods: This retrospective cohort study involved 16 eyes of 15 patients who underwent COMET for symblepharon release and fornix reconstruction between June 2002 and December 2008. The mean postoperative follow-up period was 102. Read More

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AMNIOTIC MEMBRANE TRANSPLANTATION AT THE DEPARTMENT OF OPHTHALMOLOGY OF THE UNIVERSITY HOSPITAL BRNO.

Cesk Slov Oftalmol 2021 ;77(2):62-71

Background: The aim of the work is a discussion of amniotic membrane transplantation at the Eye Clinic of the University Hospital Brno and a retrospective evaluation of a group of patients for the period 2014-2019 who were treated for various indications.

Methods: Retrospective evaluation of the number and effectiveness of individual types of amniotic membrane in a group of patients after amniotic membrane transplantation (AMT) for various indications. A total of 134 patients were included in the study group, of which 68 were men and 66 were women. Read More

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A novel case of ocular cicatricial pemphigoid induced by levamisole-adulterated cocaine.

Eur J Ophthalmol 2021 Apr;31(1_suppl):11-15

Department of Ophthalmology, King's College Hospital, London, UK.

Aim: To report a case of ocular cicatricial pemphigoid caused by levamisole-adulterated cocaine.

Methods: Case report.

Results: A 54-year-old woman with multi-systemic levamisole-induced vasculitis which triggered bilateral cicatrizing conjunctivitis refractory to conventional immunosuppressants due to continued cocaine misuse. Read More

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Successful treatment of Brunsting-Perry pemphigoid with dupilumab.

JAAD Case Rep 2021 Apr 23;10:107-109. Epub 2021 Feb 23.

Forest Dermatology, Asheville, North Carolina.

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Development of pemphigus foliaceus in a mucous membrane pemphigoid patient: An insight into possible mechanism eliciting a distinct autoimmune bullous disease in a rare anti-basement membrane autoimmunity.

J Dermatol 2021 May 16;48(5):710-714. Epub 2021 Mar 16.

Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan.

Mucous membrane pemphigoid (MMP) rarely coexists with another autoimmune bullous disease (AIBD). Herein, we report an extremely rare MMP case who sequentially developed pemphigus foliaceus (PF). A 72-year-old man had been treated by azathioprine monotherapy for anti-BP180 MMP for 1. Read More

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Crossreactivity: The possible role of oral microbiota in oral mucous membrane pemphigoid.

Autoimmun Rev 2021 May 13;20(5):102799. Epub 2021 Mar 13.

Department of Medicine and Surgery, Centre of Neuroscience of Milan, University of Milano-Bicocca, 20126 Milan, Italy.

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Proposal of a minimally invasive approach diagnosing desquamative gingivitis-associated diseases.

J Indian Soc Periodontol 2021 Jan-Feb;25(1):83-85. Epub 2021 Jan 7.

Department of Dentistry, Amazonas State University, Manaus, AM, Brazil.

Background: We aimed to present a minimally invasive clinical approach to collect a suitable sample for the laboratory diagnosis of desquamative gingivitis.

Materials And Methods: The proposed technique involves Nikolsky's test for the collection of tissue samples. It consists of the histopathological analysis of the bullous membrane formed in cases with positive Nikolsky's sign (NS). Read More

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January 2021

Ocular Cicatricial Pemphigoid, Sjögren's Syndrome, and Hashimoto's Thyroiditis as a Multiple Autoimmune Syndrome: A case report.

Eur J Ophthalmol 2021 Feb 18:1120672121996637. Epub 2021 Feb 18.

Research Group in Neurosciences NeURos, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To present a rare and novel association of Ocular Cicatricial Pemphigoid, Sjögren's Syndrome, and Hashimoto's Thyroiditis as a Multiple Autoimmune Syndrome.

Case Report: A 43-year-old Colombian female, presented with corneal ulcers, associated with trichiasis. At the ophthalmological examination forniceal shortening OU and symblepharon OD was found. Read More

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February 2021

Rituximab as an Adjuvant Rescue Treatment for Ocular Cicatricial Pemphigoid.

Cornea 2021 Feb 15. Epub 2021 Feb 15.

University of Alabama at Birmingham Department of Dermatology, Birmingham, AL; University of Alabama at Birmingham Department of Ophthalmology, Birmingham, AL; University of Mississippi Medical Center Department of Dermatology, Jackson, MS; University of Alabama at Birmingham Department of Dermatology, Birmingham, AL; and University of Central Florida Department of Medicine, Orlando, FL.

Purpose: Ocular cicatricial pemphigoid (OCP) can lead to devastating ocular complications without prompt treatment. A number of immunomodulatory agents have been attempted with varying success. The objective of this study was to evaluate the use of rituximab as an adjuvant to immunomodulatory treatments (IMTs) in refractory OCP. Read More

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February 2021

A Case of Black Fungal Keratitis Caused by Biatriospora mackinnonii.

Cornea 2021 Jan 27. Epub 2021 Jan 27.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; National Center for Geriatrics and Gerontology, Aichi, Japan; and Medical Mycology Research Center, Chiba University, Chiba, Japan.

Purpose: To report a novel case of fungal keratitis caused by Biatriospora mackinnonii (Pyrenochaeta mackinnonii), a dematiaceous fungus (black fungus) that rarely causes dermatological infection, in a patient treated for ocular cicatricial pemphigoid.

Methods: An 81-year-old patient with ocular cicatricial pemphigoid was referred to our hospital because of persistent corneal epithelial defects in his left eye. On examination, a slightly elevated dark lesion in the middle of the erosion and hypopyon was observed in that eye, with smear examination of the obtained specimen revealed a filamentous fungal-like material. Read More

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January 2021

Ocular Cicatricial Pemphigoid: Methotrexate as an Initial Treatment?

Reumatol Clin (Engl Ed) 2021 Jan 13. Epub 2021 Jan 13.

Servicio de Reumatología, Hospital Militar Central 601 Cirujano Mayor Doctor Cosme Argerich, Buenos Aires, Argentina.

Objective: To analyse the clinical / epidemiological data, the management and the treatments established in patients with ocular cicatricial pemphigoid in a Rheumatology Service.

Material And Methods: Review of clinical histories of patients with ocular cicatricial pemphigoid referred by ophthalmology between 2008 and 2019.

Results: In our series of 27 patients, 67% were diagnosed and referred in the last 2 years. Read More

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January 2021

Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease.

Case Rep Dent 2020 22;2020:8885158. Epub 2020 Dec 22.

Graduate Program in Clinical Dentistry, School of Dental Health, Universidade Positivo, Curitiba, Paraná, Brazil.

Desquamative gingivitis is an oral sign of systemic changes that may be symptomatic or asymptomatic. It is generally related to immunological changes. This report is aimed at describing the case of a 51-year-old female patient, who presented with clinical desquamative gingivitis and was initially diagnosed and treated as necrotizing periodontal disease, but no improvement. Read More

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December 2020

Ocular pseudopemphigoid with concomitant eyelid dermatitis secondary to rosacea.

JAAD Case Rep 2021 Jan 17;7:62-64. Epub 2020 Nov 17.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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January 2021

Laryngeal mucous membrane pemphigoid: transnasal laryngoscopy to highlight a severe case.

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Guy's and St Thomas' Hospitals NHS Trust, London, London, UK.

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December 2020

Cicatricial conjunctivitis secondary to discoid lupus erythematosus.

JAAD Case Rep 2020 Dec 29;6(12):1323-1326. Epub 2020 Aug 29.

University of California San Francisco Department of Dermatology, San Francisco, California.

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December 2020

Oral Mucosal Epithelial Transplantation and Limbal-Rigid Contact Lens: A Therapeutic Modality for the Treatment of Severe Ocular Surface Disorders.

Cornea 2020 Nov;39 Suppl 1:S19-S27

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and severe thermal or chemical injury are considered severe ocular surface disorders (OSDs) because they affect the entire ocular surface, including corneal and conjunctival epithelial stem cells. In patients with severe OSDs, the long-term prognosis for limbal transplantation is poor, and the related corneal opacity and cicatrization lead to devastating visual impairment. To date, there is no standardized treatment to improve vision in cases with severe OSD. Read More

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November 2020

Pseudopemphigoid: Sarcoidosis presenting as cicatricial conjunctivitis with symblepharon.

Eur J Ophthalmol 2020 Nov 2:1120672120969046. Epub 2020 Nov 2.

Department of Ophthalmology, New York University Langone Medical Center, New York, NY, USA.

Conjunctival involvement in sarcoidosis is commonly characterized by epibulbar nodules or follicular conjunctivitis. The authors describe an apparently healthy woman who developed extensive monocular cicatricial conjunctivitis with symblepharon. The array of conditions presenting with cicatricial conjunctivitis was considered, with mucous membrane pemphigoid leading the diagnostic possibilities. Read More

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November 2020

Chronic cicatrizing conjunctivitis: A review of the differential diagnosis and an algorithmic approach to management.

Indian J Ophthalmol 2020 Nov;68(11):2349-2355

The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Cicatrizing conjunctivitis constitutes a group of chronic local and systemic disorders that cause conjunctival scarring. A systematic approach is required to sift through the clinical history, examination, and laboratory investigations of patients to arrive at the correct diagnosis of the underlying cause. Establishing the etiology is critical, as the therapeutic approach changes based on the cause of conjunctival inflammation. Read More

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November 2020

Disease Relapse After Drug-Free Remission in Ocular Mucous Membrane Pemphigoid.

Am J Ophthalmol 2021 03 23;223:21-27. Epub 2020 Sep 23.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. Electronic address:

Purpose: To quantitate the risk of relapse of ocular and extraocular disease among patients with mucous membrane pemphigoid (MMP) who had undergone drug-free remission.

Design: Retrospective, comparative, interventional case series.

Methods: There were 167 patients with biopsy-proven MMP who were seen at the Wilmer Eye Institute between November 1984 and December 2019. Read More

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Ocular cicatricial pemphigoid (Review).

Exp Ther Med 2020 Oct 7;20(4):3379-3382. Epub 2020 Jul 7.

Department of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Ocular cicatricial pemphigoid is a particular form of mucous membrane pemphigoid and it is characterized by a chronic bilateral conjunctivitis with relapsing-remitting periods. Without therapy 75% of the cases develop visual loss due to major ocular complications (e.g. Read More

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October 2020

Autoimmune blisters in the gingiva.

BMJ Case Rep 2020 Sep 6;13(9). Epub 2020 Sep 6.

Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, Japan.

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September 2020

Transmucosal Boston Keratoprosthesis Type I in a Patient With Advanced Ocular Cicatricial Pemphigoid.

Cornea 2020 Dec;39(12):1563-1565

Centro de Oftalmología Barraquer, Barcelona, Spain; and.

Purpose: To describe a novel surgical technique using the Boston Keratoprosthesis (KPro) type I in a patient with advanced ocular cicatricial pemphigoid (OCP) using oral mucosa for covering the prosthesis.

Methods: We present the case of an 85-year-old man previously diagnosed with type 2 diabetes and advanced OCP nonresponsive to immunosuppressive treatment, whose best-corrected visual acuity was light perception and projection in both eyes. After examination, Boston KPro type I in the right eye was contemplated because osteo-odonto KPro and Tibial bone KPro were not feasible because of the patient's osteoporosis and edentulism. Read More

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December 2020

Single Center Retrospective Study of Patients with Ocular Mucous Membrane Pemphigoid (MMP).

Ocul Immunol Inflamm 2020 Aug 24:1-6. Epub 2020 Aug 24.

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose: Mucous membrane pemphigoid (MMP) with ocular involvement often leads to devastating vision loss from ocular surface disease. This study sought to better characterize presenting symptoms, clinical characteristics, important factors in clinical progression, and visual acuity over time.

Methods: A retrospective chart review was performed on 88 patients seen at the Emory Eye Center between January 1, 2012 and July 1, 2017 for ocular MMP. Read More

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The efficacy of rituximab in patients with mucous membrane pemphigoid.

J Dermatolog Treat 2020 Aug 11:1-7. Epub 2020 Aug 11.

Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder with tendency to scarring. Long term immunosuppressive treatment may be required to minimize the consequences of the disease.

Methods: In this retrospective study, we investigated the efficacy of rituximab (RTX) in MMP patients and compare the beneficial effects of early versus late administration of RTX. Read More

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Ocular cicatricial pemphigoid.

Rom J Ophthalmol 2020 Apr-Jun;64(2):226-230

University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania.

Ocular cicatricial pemphigoid (OCP) is an autoimmune ocular disease that causes severe dry eye syndrome, conjunctival scarring with inferior fornix shortening and entropion along with trichiasis. Corneal keratinization and corneal ulcers may lead to permanent vision loss. The therapeutic approach of OCP is a challenging one. Read More

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