4,565 results match your criteria Chronobiology International [Journal]


Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans.

Am J Clin Nutr 2018 Dec;108(6):1209-1219

Departments of Clinical Nutrition.

Background: A diet in which fat is mainly eaten in the morning and carbohydrates mainly in the evening (compared with the reverse order) was recently shown to worsen glycemic control in people with prediabetes.

Objective: We investigated the effects of these dietary patterns on energy metabolism, and on the daily profiles of circulating lipids, adipokines, and inflammatory markers.

Design: In a randomized controlled crossover trial, 29 nonobese men (with normal glucose tolerance, n = 18; or impaired fasting glucose/glucose tolerance, n = 11) underwent 2 isocaloric 4-wk diets: 1) carbohydrate-rich meals until 1330 and fat-rich meals between 1630 and 2200 (HC/HF); or 2) the inverse sequence of meals (HF/HC). Read More

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December 2018

The Method of Silent Substitution for Examining Melanopsin Contributions to Pupil Control.

Front Neurol 2018 27;9:941. Epub 2018 Nov 27.

Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.

The human pupillary light response is driven by all classes of photoreceptors in the human eye-the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights ("metamers") to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. Read More

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November 2018
1 Read

Circadian clocks and insulin resistance.

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

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December 2018
1 Read

The pain dynamics of small fiber neuropathy.

J Pain 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, Maastricht University Medical Center+, 6202 AZ Maastricht, the Netherlands. Electronic address:

Pain is a central feature in small fiber neuropathy (SFN), with only moderate effects of pharmacological treatment. The evaluation of the efficacy of therapies on pain has been driven by static measures, while a circadian cycle has been suggested. The aim of this study is to evaluate the pain dynamics in SFN. Read More

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December 2018

Shift work, sleep disturbances and social jetlag in healthcare workers.

J Sleep Res 2018 Dec 5:e12802. Epub 2018 Dec 5.

Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

The aim of this study was to compare chronotype- and age-dependent sleep disturbances and social jetlag between rotating shift workers and non-shift workers, and between different types of shifts. In the Klokwerk+ cohort study, we included 120 rotating shift workers and 74 non-shift workers who were recruited from six Dutch hospitals. Participants wore Actigraph GT3X accelerometers for 24 hr for 7 days. Read More

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December 2018

Melatonin receptor 1B -1193T>C polymorphism is associated with diurnal preference and sleep habits.

Sleep Med 2018 Oct 13;53:106-114. Epub 2018 Oct 13.

Laboratory of Molecular Chronobiology, Federal University of Alagoas (UFAL), Alagoas, Brazil; Faculty of Medicine, Federal University of Alagoas (UFAL), Alagoas, Brazil. Electronic address:

Background: Melatonin modulates the master circadian clock through the activation of G-protein-coupled receptors MT1 and MT2. It is presumed, therefore, that genetic variations in melatonin receptors can affect both sleep and circadian phase. We investigated whether the -1193T > C (rs4753426) polymorphism in the promoter of MT2 receptor gene (MTNR1B) is associated with diurnal preference and sleep habits. Read More

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October 2018

Strategies to decrease social jetlag: reducing evening blue light advances sleep and melatonin.

Eur J Neurosci 2018 Dec 2. Epub 2018 Dec 2.

Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, NL,.

The timing of sleep is under the control of the circadian clock, which uses light to entrain to the external light-dark cycle. A combination of genetic, physiological and environmental factors produces individual differences in chronotype (entrained phase as manifest in sleep timing). A mismatch between circadian and societal (e. Read More

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December 2018

Spliceosome factors target timeless () mRNA to control clock protein accumulation and circadian behavior in Drosophila.

Elife 2018 12 5;7. Epub 2018 Dec 5.

Chronobiology Program at Penn, Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

Transcription-translation feedback loops that comprise eukaryotic circadian clocks rely upon temporal delays that separate the phase of active transcription of clock genes, such as Drosophila and from negative feedback by the two proteins. However, our understanding of the mechanisms involved is incomplete. Through an RNA interference screen, we found that pre-mRNA processing 4 (PRP4) kinase, a component of the U4/U5. Read More

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December 2018
1 Read

Heart rate variability changes in major depressive disorder during sleep: Fractal index correlates with BDI score during REM sleep.

Psychiatry Res 2018 Nov 12;271:291-298. Epub 2018 Nov 12.

Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Read More

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November 2018
6 Reads

Chronotype and beyond: 17 building blocks to reconcile and explore internal time architecture.

Chronobiol Int 2018 Dec 4:1-5. Epub 2018 Dec 4.

a Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research , University Hospital of Cologne , Cologne , Germany.

Chronotype, defined as the temporal phenotype of an organism, has been addressed in Chronobiology International in some 200 publications between 1997 and 2018. Readers may thus be interested in what roles chronotype may play in studies concerning chronobiology and health. In line with Karl Popper, our objective is to synthesize terms and concepts for falsifiable experimental, field, and ultimately epidemiological research. Read More

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December 2018

Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal.

Behav Brain Res 2018 Nov 27. Epub 2018 Nov 27.

Department of Molecular Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.

Somatic and motivational symptoms accompanying opiate withdrawal are considered one of the major reasons for relapse to opiate-seeking and opiate-taking behaviors. These symptoms are accompanied by the activation of stress-related processes including hypothalamic-pituitary-adrenal axis activity and noradrenergic (NA) signaling. In particular, the NA system plays an important role in the expression of somatic signs of opiate withdrawal, whereas glucocorticoid (GR) and mineralocorticoid receptors (MR) are activated during opiate abstinence. Read More

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November 2018
1 Read

Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity.

J Pediatr 2018 Nov 19. Epub 2018 Nov 19.

Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO; Center for Women's Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO.

Objectives: To examine the relationship between insulin resistance (IR) and sleep/circadian health in overweight/obese adolescents. We hypothesized that insufficient and delayed sleep would be associated with IR in this population.

Study Design: Thirty-one adolescents (mean age, 16. Read More

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November 2018
1 Read

Daylight saving time and circadian rhythms in the neuro-endocrine-immune system: impact on cardiovascular health.

Intern Emerg Med 2018 Nov 28. Epub 2018 Nov 28.

Division of Internal Medicine and Laboratory of Chronobiology, Department of Medical Sciences, Fondazione IRCCS "Casa Sollievo Della Sofferenza", Cappuccini Avenue, San Giovanni Rotondo, Foggia, 71013, Italy.

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November 2018

Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways.

Cancer Control 2018 Jan-Dec;25(1):1073274818812908

1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel.

Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. Read More

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November 2018
1 Read

Ultradian Rhythms in the Transcriptome of Neurospora crassa.

iScience 2018 Nov 10;9:475-486. Epub 2018 Nov 10.

Institute for Theoretical Biology, Humboldt-Universität zu Berlin, 10115 Berlin, Germany; Charité Universitätsmedizin, 10117 Berlin, Germany.

In many organisms, the circadian clock drives rhythms in the transcription of clock-controlled genes that can be either circadian (∼24-hr period) or ultradian (<24-hr period). Ultradian rhythms with periods that are a fraction of 24 hr are termed harmonics. Several harmonic transcripts were discovered in the mouse liver, but their functional significance remains unclear. Read More

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November 2018
3 Reads

Automatic Human Sleep Stage Scoring Using Deep Neural Networks.

Front Neurosci 2018 6;12:781. Epub 2018 Nov 6.

Chronobiology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

The classification of sleep stages is the first and an important step in the quantitative analysis of polysomnographic recordings. Sleep stage scoring relies heavily on visual pattern recognition by a human expert and is time consuming and subjective. Thus, there is a need for automatic classification. Read More

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November 2018
13 Reads

Sleep and Metabolism: Eaat-ing Your Way to ZZZs.

Curr Biol 2018 Nov 19;28(22):R1310-R1312. Epub 2018 Nov 19.

Departments of Psychiatry and Neuroscience, Chronobiology Program, and Center for Sleep and Circadian Neurobiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

A new study in fruit flies identifies a molecule, Eaat2, that regulates both sleep and metabolic rate. Surprisingly, Eaat2 acts in a specific glial subtype to modulate both processes, suggesting a cellular link in the brain between sleep and metabolism. Read More

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November 2018

Co-existing feedback loops generate tissue-specific circadian rhythms.

Life Sci Alliance 2018 Jun 14;1(3):e201800078. Epub 2018 Jun 14.

Institute for Theoretical Biology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Gene regulatory feedback loops generate autonomous circadian rhythms in mammalian tissues. The well-studied core clock network contains many negative and positive regulations. Multiple feedback loops have been discussed as primary rhythm generators but the design principles of the core clock and differences between tissues are still under debate. Read More

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June 2018
3 Reads

Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study.

Front Physiol 2018 5;9:1530. Epub 2018 Nov 5.

Department of Medicine, University of Padova, Padova, Italy.

Patients with Primary Biliary Cholangitis (PBC) exhibit delayed sleep-wake habits, disturbed night sleep and daytime sleepiness/fatigue. Such combination of symptoms is reminiscent of delayed sleep-wake phase disorder (DSPD), which benefits from morning light treatment. The aim of the present pilot study was to test the effect of morning light treatment in a group of 13 well-characterized patients with PBC [all females; (mean ± SD) 53 ± 10 years]. Read More

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November 2018
2 Reads

Wind Turbine Noise and Sleep: Pilot Studies on the Influence of Noise Characteristics.

Int J Environ Res Public Health 2018 Nov 17;15(11). Epub 2018 Nov 17.

Department of Occupational and Environmental Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.

The number of onshore wind turbines in Europe has greatly increased over recent years, a trend which can be expected to continue. However, the effects of wind turbine noise on long-term health outcomes for residents living near wind farms is largely unknown, although sleep disturbance may be a cause for particular concern. Presented here are two pilot studies with the aim of examining the acoustical properties of wind turbine noise that might be of special relevance regarding effects on sleep. Read More

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November 2018
1 Read

Dose-dependent effects of continuous positive airway pressure for sleep apnea on weight or metabolic function: Individual patient-level clinical trial meta-analysis.

J Sleep Res 2018 Nov 19:e12788. Epub 2018 Nov 19.

Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.

Therapeutic-continuous positive airway pressure seems to increase weight compared with placebo-continuous positive airway pressure. It is not known whether weight gain with therapeutic-continuous positive airway pressure dose is dependent or whether it causes metabolic dysfunction. Data synthesis of three randomised placebo-continuous positive airway pressure-controlled trials (2-3 months) was performed to test whether there is a dose-dependent effect of continuous positive airway pressure on weight. Read More

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November 2018
2 Reads

Identification of novel circadian transcripts in the zebrafish retina.

J Exp Biol 2018 Nov 16. Epub 2018 Nov 16.

CSIR-Institute of Genomics and Integrative Biology (IGIB), Mathura Road, New Delhi, India

High fecundity, transparent embryos for monitoring the rapid development of organs and the availability of a well-annotated genome has made zebrafish a model organism of choice for developmental biology and neurobiology. This vertebrate model, a favourite in chronobiology studies, shows striking circadian rhythmicity in behaviour. Here, we identify novel genes in the zebrafish genome, which are expressed in the zebrafish retina. Read More

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November 2018
4 Reads
2.900 Impact Factor

Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances.

J Affect Disord 2018 Nov 5;245:608-616. Epub 2018 Nov 5.

Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0804, United States.

Background: Peripartum major depression (MD) disables mothers and impairs emotional and neurocognitive development of offspring. We tested the hypothesis that critically-timed wake therapy (WT) relieves peripartum MD by altering melatonin and sleep timing, differentially, in antepartum vs. postpartum depressed patients (DP). Read More

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November 2018
6 Reads

Acute Sleep Restriction Has Differential Effects on Components of Attention.

Front Psychiatry 2018 30;9:499. Epub 2018 Oct 30.

Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.

Inadequate nightly sleep duration can impair daytime functioning, including interfering with attentional and other cognitive processes. Current models posit that attention is a complex function regulated by several separate, but interacting, neural systems responsible for vigilance, orienting, and executive control. However, it is not clear to what extent each of these underlying component processes is affected by sleep loss. Read More

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October 2018
5 Reads

Moonlight enhances growth in larval fish.

Ecology 2018 Nov 13. Epub 2018 Nov 13.

School of BioSciences, University of Melbourne, Melbourne, 3010, Australia.

Moonlight mediates trophic interactions and shapes the evolution of life-history strategies for nocturnal organisms. Reproductive cycles and important life-history transitions for many marine organisms coincide with moon phases, but few studies consider the effects of moonlight on pelagic larvae at sea. We evaluated effects of moonlight on growth of pelagic larvae of a temperate reef fish using 'master chronologies' of larval growth constructed from age-independent daily increment widths recorded in otoliths of 321 individuals. Read More

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November 2018

Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: Effect of different noise scenarios.

Environ Int 2018 Dec 4;121(Pt 1):1011-1023. Epub 2018 Jul 4.

Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Switzerland. Electronic address:

Background: Epidemiological evidence indicates an association between transportation noise exposure and a higher risk of developing type 2 diabetes. Sleep disturbances are thought to be one of the mechanisms as it is well established that a few nights of short or poor sleep impair glucose tolerance and insulin sensitivity in healthy good sleepers.

Objectives: The present study aimed to determine the extent to which exposure to nocturnal transportation noise affects glucose metabolism, and whether it is related to noise-induced sleep alterations. Read More

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December 2018
4 Reads

Circadian and Sleep Circuits Ring Together.

Neuron 2018 Nov;100(3):514-516

Penn Chronobiology, Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Prolonged wakefulness stimulates the homeostatic need to sleep, but transition to sleep also depends on the circadian time of day. However, links between circadian and homeostatic influences are not well understood. Guo et al. Read More

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November 2018
5 Reads

Trends in prescriptions for sedative-hypnotics among Korean adults: a nationwide prescription database study for 2011-2015.

Soc Psychiatry Psychiatr Epidemiol 2018 Nov 7. Epub 2018 Nov 7.

Department of Psychiatry, Center for Sleep and Chronobiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Purpose: This study investigated prescriptions for sedative-hypnotics via data obtained from the Health Insurance Review and Assessment (HIRA) service.

Methods: Data on sedative-hypnotic prescriptions from the HIRA service of the Republic of Korea were analyzed from 2011 to 2015. We included prescriptions for subjects > 18 years of age from hospitals and community healthcare centers. Read More

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November 2018
4 Reads

The factors influencing the eating behaviour of shiftworkers: what, when, where and why.

Ind Health 2018 Nov 8. Epub 2018 Nov 8.

Sleep and Chronobiology Laboratory, Behaviour Brain Body Research Centre, University of South Australia, Australia.

Shiftwork leads to altered eating patterns, with workers often eating foods at all times across the 24h period. Strategies to reduce the burden of shiftwork on the workers should be prioritised and altering these eating patterns is an important area for change. This narrative review examines the current evidence on the individual and environmental factors influencing the eating behaviours of shiftworkers. Read More

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November 2018
3 Reads

A test case for Mars: human sleep and performance during a 13 month stay in Antarctica.

Sleep 2018 Nov 7. Epub 2018 Nov 7.

Department PSYC, Vrije Universiteit Brussel (V.U.B.), Brussels, Belgium.

Study Objectives: Manned spaceflights from Earth to Mars will likely become reality within the next decades. Humans will be exposed to prolonged isolation, confinement, and altered photoperiods in artificial atmospheric conditions, with potential adverse effects on sleep and performance. On Earth, polar environments serve as space-analogues to study human adaptation, yet few studies include polysomnography due to operational constraints. Read More

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November 2018
6 Reads

The added value of cognitive behavioral therapy for insomnia to current best evidence physical therapy for chronic spinal pain: protocol of a randomized controlled clinical trial.

Braz J Phys Ther 2018 Oct 29. Epub 2018 Oct 29.

Pain in Motion International Research Group(1); Department of Physiotherapy, Human Physiology and Anatomy (KIMA), Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussel, Belgium; Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels Belgium.

Background: Insomnia is a highly prevalent and debilitating comorbidity that is often not addressed in therapy for chronic spinal pain (CSP). Given the close interaction between insomnia and CSP severity and related disability, targeting sleep problems during therapy could improve treatment outcomes in these patients.

Objective: Can cognitive behavioral therapy for insomnia (CBT-I) combined with the modern neuroscience approach (i. Read More

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October 2018
5 Reads

Population-level rhythms in human skin with implications for circadian medicine.

Proc Natl Acad Sci U S A 2018 Nov 30;115(48):12313-12318. Epub 2018 Oct 30.

Division of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

Skin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. The epidermal layer shows rhythmic physiological responses to daily environmental variation (e.g. Read More

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November 2018

Linking sleep disturbance to idiopathic male infertility.

Sleep Med Rev 2018 12 3;42:149-159. Epub 2018 Aug 3.

CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia; Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, New South Wales, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia.

Recently published data suggests that male fertility has declined over the past four decades. The reasons for the decline are unclear with up to 50% of cases of male infertility remaining unexplained (idiopathic male infertility). Whilst environmental factors and rising rates of obesity have been implicated, there is now growing evidence that sleep disturbance may be an independent causative factor. Read More

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December 2018
2 Reads

Circadian rhythm and epilepsy.

Lancet Neurol 2018 Dec 23;17(12):1098-1108. Epub 2018 Oct 23.

Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery and Institute of Neurology, University College London, London, UK. Electronic address:

Advances in diagnostic technology, including chronic intracranial EEG recordings, have confirmed the clinical observation of different temporal patterns of epileptic activity and seizure occurrence over a 24-h period. The rhythmic patterns in epileptic activity and seizure occurrence are probably related to vigilance states and circadian variation in excitatory and inhibitory balance. Core circadian genes BMAL1 and CLOCK, which code for transcription factors, have been shown to influence excitability and seizure threshold. Read More

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December 2018
7 Reads

Chronic Heart Failure Abolishes Circadian Rhythms in Resting and Chemoreflex Breathing.

Adv Exp Med Biol 2018 ;1071:129-136

Department of Cellular and Integrative Physiology at the University of Nebraska Medical Center, Omaha, NE, USA.

Physiological systems often display 24 h rhythms that vary with the light/dark cycle. Disruption of circadian physiological rhythms have been linked to the progression of various cardiovascular diseases, and advances in the understanding of these rhythms have led to novel interventions and improved clinical outcomes. Although respiratory function has been known to vary between the light and dark periods, circadian rhythms in breathing have been understudied in clinical conditions. Read More

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January 2018
5 Reads

A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland.

Eur Heart J 2018 Oct 24. Epub 2018 Oct 24.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel, Switzerland.

Aims: The present study aimed to disentangle the risk of the three major transportation noise sources-road, railway, and aircraft traffic-and the air pollutants NO2 and PM2.5 on myocardial infarction (MI) mortality in Switzerland based on high quality/fine resolution exposure modelling.

Methods And Results: We modelled long-term exposure to outdoor road traffic, railway, and aircraft noise levels, as well as NO2 and PM2. Read More

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October 2018
1 Read

Editorial: Let There Be Light: Biological Impact of Light Exposure in the Laboratory and the Clinic.

Front Neurol 2018 9;9:851. Epub 2018 Oct 9.

Department of Science and Technology, Universidad Nacional de Quilmes, Bernal, Argentina.

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October 2018
2 Reads

Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study.

J Clin Sleep Med 2018 Oct 15;14(10):1669-1677. Epub 2018 Oct 15.

Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

Study Objectives: Researchers have previously reported a possible association between sedative-hypnotics and increased mortality. However, the relationship remains controversial. We investigated the association between sedative-hypnotics and mortality using a large population-based database from the Republic of Korea. Read More

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October 2018

Long-term exposure to transportation noise and its association with adiposity markers and development of obesity.

Environ Int 2018 Dec 19;121(Pt 1):879-889. Epub 2018 Oct 19.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

The contribution of different transportation noise sources to metabolic disorders such as obesity remains understudied. We evaluated the associations of long-term exposure to road, railway and aircraft noise with measures of obesity and its subphenotypes using cross-sectional and longitudinal designs. We assessed 3796 participants from the population-based Swiss Cohort Study on Air Pollution and Lung and Heart Diseases (SAPALDIA), who attended the visits in 2001 (SAP2) and 2010/2011 (SAP3) and who were aged 29-72 at SAP2. Read More

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December 2018
4 Reads

Individual Chronotype May Confound with Asthma Symptoms and Therapy.

Am J Respir Crit Care Med 2018 Oct 22. Epub 2018 Oct 22.

Allergy & Asthma Research Centre, Kolkata, India.

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October 2018

Sleep interventions for osteoarthritis and spinal pain: a systematic review and meta-analysis of randomized controlled trials.

Osteoarthritis Cartilage 2018 Oct 18. Epub 2018 Oct 18.

The University of Sydney, Musculoskeletal Research Group, Faculty of Health Sciences, 75 East St, Lidcombe, Sydney, 2141 NSW, Australia. Electronic address:

Objectives: To determine if sleep interventions improve pain and sleep in people with osteoarthritis (OA) and/or spinal pain compared to control/placebo.

Design: Medline, Embase, AMED, PsycINFO, CENTRAL, CINAHL and PEDro were searched from their inception date to July 2017. Keywords relating to "sleep", "OA", "spinal pain", and "randomized controlled trial (RCT)" were combined. Read More

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October 2018
1 Read

Chronic heart failure: a disease of the brain.

Heart Fail Rev 2018 Oct 20. Epub 2018 Oct 20.

Halberg Chronobiology Center, University of Minnesota Medical School, Minneapolis, USA.

The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are the methods for this study. Since chronic HF is associated with autonomic imbalance with increased sympathetic nerve activity and a withdrawal of parasympathetic activity, it may be considered a brain disease. Read More

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October 2018
3 Reads

The loss of ecosystem-services emerging from artificial light at night.

Chronobiol Int 2018 Oct 19:1-3. Epub 2018 Oct 19.

a The Israeli Centre for Interdisciplinary Research in Chronobiology , University Haifa , Haifa , Israel.

Light pollution is increasing worldwide, affecting human health and ecosystem quality. The adverse effect of this novel pollution, mediated in mammals by suppression of the pineal neuro-hormone melatonin production and secretion, particularly by short wavelength (SWL) illumination. Currently, this problem is not challenged sufficiently, even ignored by decision-makers at local and national levels, as well as other related organizations. Read More

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October 2018
7 Reads

Microcystin-LR regulates circadian clock and antioxidant gene expression in cultured rat cardiomyocytes.

Cell Mol Biol Lett 2018 10;23:50. Epub 2018 Oct 10.

2Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029 China.

Background: Microcystins are waterborne environmental toxins that induce oxidative stress and cause injuries in the heart. On the other hand, many physiological processes, including antioxidant defense, are under precise control by the mammalian circadian clock.

Results: In the present study, we evaluated the effect of microcystin-LR (MC-LR) on the rhythmic expression patterns of circadian and antioxidant genes in rat cardiomyocytes using the serum shock technique. Read More

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October 2018
3 Reads

Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment.

Int Urol Nephrol 2018 Dec 15;50(12):2221-2228. Epub 2018 Oct 15.

Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Introduction: Chronobiology studies the phenomenon of rhythmicity in living organisms. The circadian rhythms are genetically determined and regulated by external synchronizers (the daylight cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subjected to circadian variations. Read More

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December 2018

Transportation noise exposure, noise annoyance and respiratory health in adults: A repeated-measures study.

Environ Int 2018 Dec 12;121(Pt 1):741-750. Epub 2018 Oct 12.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

Transportation noise leads to sleep disturbance and to psychological and physiological sustained stress reactions, which could impact respiratory health. However, epidemiologic evidence on associations of objective transportation noise exposure and also perceived noise annoyance with respiratory morbidity is limited. We investigated independent associations of transportation noise exposure and noise annoyance with prevalent respiratory symptoms and incident asthma in adults. Read More

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December 2018
1 Read

Integration of color and intensity increases time signal stability for the human circadian system when sunlight is obscured by clouds.

Sci Rep 2018 Oct 12;8(1):15214. Epub 2018 Oct 12.

Chronobiology unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, PO box 11103, 9700CC, Groningen, The Netherlands.

The mammalian circadian system encodes both absolute levels of light intensity and color to phase-lock (entrain) its rhythm to the 24-h solar cycle. The evolutionary benefits of circadian color-coding over intensity-coding per se are yet far from understood. A detailed characterization of sunlight is crucial in understanding how and why circadian photoreception integrates color and intensity information. Read More

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October 2018
3 Reads

Rhythms of the Genome: Circadian Dynamics from Chromatin Topology, Tissue-Specific Gene Expression, to Behavior.

Trends Genet 2018 Dec 8;34(12):915-926. Epub 2018 Oct 8.

The Institute of Bioengineering (IBI), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-h day, which requires extensive gene expression rhythms targeted to the right tissue. Although a core set of gene products oscillates across virtually all cell types, gene expression profiling across tissues over the 24-h day showed that rhythmic gene expression programs are tissue specific. Read More

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December 2018
1 Read

Chronotype, nursing activity, and gender: A systematic review.

J Adv Nurs 2018 Oct 11. Epub 2018 Oct 11.

Department of Nursing, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.

Aim: To synthesize evidence about the effect of individual circadian preference (chronotype) and gender in the development of sleep and mood problems in nursing professionals.

Background: Shift workers are more prone to having unhealthy habits and unfavourable clinical conditions than nonshift workers. These associations are mediated by chronotype and gender differences have also been detected. Read More

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October 2018
2 Reads

Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri.: comparison with a longer-living Nothobranchius species.

Biogerontology 2018 Oct 9. Epub 2018 Oct 9.

Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Murcia, Spain.

Membrane compositions, particularly of mitochondria, could be critical factors in the mechanisms of growth and aging, especially during phases of high oxidative stress that result in molecular damage. Changes affecting lipid class or fatty acid (FA) compositions could affect phospholipid (PL) properties and alter mitochondrial function. In the present study, mitochondrial membrane PL compositions were analysed throughout the life-cycle of Nothobranchius furzeri, a species with explosive growth and one of the shortest-lived vertebrates. Read More

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October 2018
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